-- dump date   	20140619_115101
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
582402000001	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
582402000002	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
582402000003	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
582402000004	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
582402000005	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
582402000006	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582402000007	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402000008	P-loop; other site
582402000009	Magnesium ion binding site [ion binding]; other site
582402000010	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
582402000011	ParB-like nuclease domain; Region: ParBc; pfam02195
582402000012	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
582402000013	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
582402000014	Lipopolysaccharide-assembly; Region: LptE; pfam04390
582402000015	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
582402000016	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
582402000017	HIGH motif; other site
582402000018	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
582402000019	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582402000020	active site
582402000021	KMSKS motif; other site
582402000022	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
582402000023	tRNA binding surface [nucleotide binding]; other site
582402000024	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
582402000025	Gram-negative porin; Region: Porin_4; pfam13609
582402000026	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
582402000027	thiamine phosphate binding site [chemical binding]; other site
582402000028	active site
582402000029	pyrophosphate binding site [ion binding]; other site
582402000030	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
582402000031	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402000032	catalytic residue [active]
582402000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
582402000034	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582402000035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000036	active site
582402000037	phosphorylation site [posttranslational modification]
582402000038	intermolecular recognition site; other site
582402000039	dimerization interface [polypeptide binding]; other site
582402000040	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402000041	DNA binding site [nucleotide binding]
582402000042	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
582402000043	putative catalytic site [active]
582402000044	putative phosphate binding site [ion binding]; other site
582402000045	active site
582402000046	metal binding site A [ion binding]; metal-binding site
582402000047	DNA binding site [nucleotide binding]
582402000048	putative AP binding site [nucleotide binding]; other site
582402000049	putative metal binding site B [ion binding]; other site
582402000050	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
582402000051	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
582402000052	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
582402000053	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
582402000054	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
582402000055	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
582402000056	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
582402000057	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582402000058	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
582402000059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
582402000060	Uncharacterized conserved protein [Function unknown]; Region: COG2835
582402000061	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
582402000062	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
582402000063	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
582402000064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402000065	TPR motif; other site
582402000066	binding surface
582402000067	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
582402000068	putative deacylase active site [active]
582402000069	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
582402000070	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
582402000071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402000072	Walker A/P-loop; other site
582402000073	ATP binding site [chemical binding]; other site
582402000074	Q-loop/lid; other site
582402000075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402000076	Walker B; other site
582402000077	D-loop; other site
582402000078	H-loop/switch region; other site
582402000079	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
582402000080	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
582402000081	active site
582402000082	metal binding site [ion binding]; metal-binding site
582402000083	DNA binding site [nucleotide binding]
582402000084	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
582402000085	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
582402000086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402000087	FeS/SAM binding site; other site
582402000088	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402000089	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
582402000090	motif 1; other site
582402000091	dimer interface [polypeptide binding]; other site
582402000092	active site
582402000093	motif 2; other site
582402000094	motif 3; other site
582402000095	elongation factor P; Validated; Region: PRK00529
582402000096	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
582402000097	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
582402000098	RNA binding site [nucleotide binding]; other site
582402000099	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
582402000100	RNA binding site [nucleotide binding]; other site
582402000101	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
582402000102	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
582402000103	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
582402000104	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
582402000105	Low molecular weight phosphatase family; Region: LMWPc; cd00115
582402000106	active site
582402000107	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
582402000108	substrate binding site [chemical binding]; other site
582402000109	hypothetical protein; Validated; Region: PRK06886
582402000110	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402000111	active site
582402000112	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
582402000113	DNA photolyase; Region: DNA_photolyase; pfam00875
582402000114	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
582402000115	hypothetical protein; Validated; Region: PRK00110
582402000116	NAD-dependent deacetylase; Provisional; Region: PRK00481
582402000117	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
582402000118	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
582402000119	active site
582402000120	catalytic triad [active]
582402000121	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402000122	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402000123	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
582402000124	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402000125	catalytic core [active]
582402000126	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402000127	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
582402000128	catalytic motif [active]
582402000129	Zn binding site [ion binding]; other site
582402000130	AAA domain; Region: AAA_31; pfam13614
582402000131	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402000132	P-loop; other site
582402000133	Magnesium ion binding site [ion binding]; other site
582402000134	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
582402000135	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402000136	Magnesium ion binding site [ion binding]; other site
582402000137	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
582402000138	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
582402000139	putative tRNA-binding site [nucleotide binding]; other site
582402000140	B3/4 domain; Region: B3_4; pfam03483
582402000141	tRNA synthetase B5 domain; Region: B5; smart00874
582402000142	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
582402000143	dimer interface [polypeptide binding]; other site
582402000144	motif 1; other site
582402000145	motif 3; other site
582402000146	motif 2; other site
582402000147	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
582402000148	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
582402000149	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
582402000150	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
582402000151	dimer interface [polypeptide binding]; other site
582402000152	motif 1; other site
582402000153	active site
582402000154	motif 2; other site
582402000155	motif 3; other site
582402000156	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
582402000157	Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929
582402000158	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
582402000159	23S rRNA binding site [nucleotide binding]; other site
582402000160	L21 binding site [polypeptide binding]; other site
582402000161	L13 binding site [polypeptide binding]; other site
582402000162	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
582402000163	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
582402000164	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
582402000165	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
582402000166	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
582402000167	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
582402000168	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
582402000169	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582402000170	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402000171	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
582402000172	putative ADP-binding pocket [chemical binding]; other site
582402000173	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582402000174	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
582402000175	catalytic site [active]
582402000176	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
582402000177	putative NAD(P) binding site [chemical binding]; other site
582402000178	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582402000179	TPR repeat; Region: TPR_11; pfam13414
582402000180	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
582402000181	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582402000182	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
582402000183	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582402000184	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582402000185	threonine dehydratase; Provisional; Region: PRK07334
582402000186	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
582402000187	tetramer interface [polypeptide binding]; other site
582402000188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402000189	catalytic residue [active]
582402000190	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
582402000191	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
582402000192	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582402000193	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
582402000194	HemY protein N-terminus; Region: HemY_N; pfam07219
582402000195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
582402000196	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
582402000197	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
582402000198	active site
582402000199	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
582402000200	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
582402000201	domain interfaces; other site
582402000202	active site
582402000203	UGMP family protein; Validated; Region: PRK09604
582402000204	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
582402000205	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
582402000206	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
582402000207	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
582402000208	YCII-related domain; Region: YCII; cl00999
582402000209	Paraquat-inducible protein A; Region: PqiA; pfam04403
582402000210	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
582402000211	active site
582402000212	dimer interface [polypeptide binding]; other site
582402000213	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
582402000214	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582402000215	Predicted membrane protein [Function unknown]; Region: COG3766
582402000216	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
582402000217	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
582402000218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402000219	FeS/SAM binding site; other site
582402000220	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
582402000221	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
582402000222	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
582402000223	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
582402000224	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
582402000225	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
582402000226	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
582402000227	Walker A/P-loop; other site
582402000228	ATP binding site [chemical binding]; other site
582402000229	Q-loop/lid; other site
582402000230	ABC transporter signature motif; other site
582402000231	Walker B; other site
582402000232	D-loop; other site
582402000233	H-loop/switch region; other site
582402000234	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
582402000235	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
582402000236	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
582402000237	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
582402000238	aconitate hydratase; Validated; Region: PRK09277
582402000239	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
582402000240	substrate binding site [chemical binding]; other site
582402000241	ligand binding site [chemical binding]; other site
582402000242	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
582402000243	substrate binding site [chemical binding]; other site
582402000244	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
582402000245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402000246	Walker A/P-loop; other site
582402000247	ATP binding site [chemical binding]; other site
582402000248	Q-loop/lid; other site
582402000249	ABC transporter signature motif; other site
582402000250	Walker B; other site
582402000251	D-loop; other site
582402000252	H-loop/switch region; other site
582402000253	heme exporter protein CcmB; Region: ccmB; TIGR01190
582402000254	heme exporter protein CcmC; Region: ccmC; TIGR01191
582402000255	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402000256	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582402000257	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402000258	MarR family; Region: MarR_2; pfam12802
582402000259	Intracellular septation protein A; Region: IspA; pfam04279
582402000260	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
582402000261	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
582402000262	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
582402000263	EamA-like transporter family; Region: EamA; pfam00892
582402000264	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
582402000265	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
582402000266	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582402000267	P loop; other site
582402000268	GTP binding site [chemical binding]; other site
582402000269	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
582402000270	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582402000271	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402000272	FeS/SAM binding site; other site
582402000273	MerC mercury resistance protein; Region: MerC; pfam03203
582402000274	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
582402000275	putative hydrophobic ligand binding site [chemical binding]; other site
582402000276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402000277	dimerization interface [polypeptide binding]; other site
582402000278	putative DNA binding site [nucleotide binding]; other site
582402000279	putative Zn2+ binding site [ion binding]; other site
582402000280	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
582402000281	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
582402000282	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
582402000283	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402000284	dimerization interface [polypeptide binding]; other site
582402000285	putative DNA binding site [nucleotide binding]; other site
582402000286	putative Zn2+ binding site [ion binding]; other site
582402000287	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
582402000288	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402000289	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
582402000290	putative catalytic residue [active]
582402000291	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582402000292	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
582402000293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402000294	ATP binding site [chemical binding]; other site
582402000295	putative Mg++ binding site [ion binding]; other site
582402000296	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402000297	nucleotide binding region [chemical binding]; other site
582402000298	ATP-binding site [chemical binding]; other site
582402000299	Helicase associated domain (HA2); Region: HA2; pfam04408
582402000300	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
582402000301	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
582402000302	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
582402000303	active site
582402000304	metal binding site [ion binding]; metal-binding site
582402000305	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
582402000306	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
582402000307	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
582402000308	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
582402000309	catalytic triad [active]
582402000310	dimer interface [polypeptide binding]; other site
582402000311	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582402000312	Cytochrome P450; Region: p450; cl12078
582402000313	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
582402000314	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402000315	acyl-activating enzyme (AAE) consensus motif; other site
582402000316	AMP binding site [chemical binding]; other site
582402000317	active site
582402000318	CoA binding site [chemical binding]; other site
582402000319	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582402000320	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
582402000321	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402000322	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402000323	hypothetical protein; Validated; Region: PRK00029
582402000324	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
582402000325	PAS fold; Region: PAS_3; pfam08447
582402000326	PAS fold; Region: PAS_4; pfam08448
582402000327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402000328	putative active site [active]
582402000329	heme pocket [chemical binding]; other site
582402000330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402000331	heme pocket [chemical binding]; other site
582402000332	putative active site [active]
582402000333	PAS fold; Region: PAS_3; pfam08447
582402000334	Response regulator receiver domain; Region: Response_reg; pfam00072
582402000335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000336	active site
582402000337	phosphorylation site [posttranslational modification]
582402000338	intermolecular recognition site; other site
582402000339	dimerization interface [polypeptide binding]; other site
582402000340	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
582402000341	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
582402000342	FAD binding pocket [chemical binding]; other site
582402000343	FAD binding motif [chemical binding]; other site
582402000344	phosphate binding motif [ion binding]; other site
582402000345	beta-alpha-beta structure motif; other site
582402000346	NAD binding pocket [chemical binding]; other site
582402000347	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582402000348	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402000349	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582402000350	Protein export membrane protein; Region: SecD_SecF; cl14618
582402000351	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
582402000352	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582402000353	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
582402000354	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
582402000355	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402000356	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
582402000357	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
582402000358	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
582402000359	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
582402000360	putative active site; other site
582402000361	catalytic triad [active]
582402000362	putative dimer interface [polypeptide binding]; other site
582402000363	glutamate racemase; Provisional; Region: PRK00865
582402000364	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
582402000365	Clp amino terminal domain; Region: Clp_N; pfam02861
582402000366	Clp amino terminal domain; Region: Clp_N; pfam02861
582402000367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402000368	Walker A motif; other site
582402000369	ATP binding site [chemical binding]; other site
582402000370	Walker B motif; other site
582402000371	arginine finger; other site
582402000372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402000373	Walker A motif; other site
582402000374	ATP binding site [chemical binding]; other site
582402000375	Walker B motif; other site
582402000376	arginine finger; other site
582402000377	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582402000378	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402000379	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402000380	dimer interface [polypeptide binding]; other site
582402000381	putative CheW interface [polypeptide binding]; other site
582402000382	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402000383	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402000384	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402000385	Dicarboxylate transport; Region: DctA-YdbH; cl14674
582402000386	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
582402000387	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
582402000388	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
582402000389	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582402000390	putative binding surface; other site
582402000391	active site
582402000392	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
582402000393	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582402000394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000395	ATP binding site [chemical binding]; other site
582402000396	Mg2+ binding site [ion binding]; other site
582402000397	G-X-G motif; other site
582402000398	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582402000399	CheW-like domain; Region: CheW; pfam01584
582402000400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000401	phosphorylation site [posttranslational modification]
582402000402	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
582402000403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000404	Response regulator receiver domain; Region: Response_reg; pfam00072
582402000405	active site
582402000406	phosphorylation site [posttranslational modification]
582402000407	intermolecular recognition site; other site
582402000408	dimerization interface [polypeptide binding]; other site
582402000409	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
582402000410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000411	active site
582402000412	phosphorylation site [posttranslational modification]
582402000413	intermolecular recognition site; other site
582402000414	dimerization interface [polypeptide binding]; other site
582402000415	CheB methylesterase; Region: CheB_methylest; pfam01339
582402000416	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
582402000417	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582402000418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402000419	S-adenosylmethionine binding site [chemical binding]; other site
582402000420	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
582402000421	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
582402000422	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
582402000423	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582402000424	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
582402000425	beta subunit interaction interface [polypeptide binding]; other site
582402000426	Walker A motif; other site
582402000427	ATP binding site [chemical binding]; other site
582402000428	Walker B motif; other site
582402000429	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582402000430	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
582402000431	core domain interface [polypeptide binding]; other site
582402000432	delta subunit interface [polypeptide binding]; other site
582402000433	epsilon subunit interface [polypeptide binding]; other site
582402000434	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
582402000435	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582402000436	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
582402000437	alpha subunit interaction interface [polypeptide binding]; other site
582402000438	Walker A motif; other site
582402000439	ATP binding site [chemical binding]; other site
582402000440	Walker B motif; other site
582402000441	inhibitor binding site; inhibition site
582402000442	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582402000443	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
582402000444	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
582402000445	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
582402000446	gamma subunit interface [polypeptide binding]; other site
582402000447	epsilon subunit interface [polypeptide binding]; other site
582402000448	LBP interface [polypeptide binding]; other site
582402000449	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402000450	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
582402000451	putative active site [active]
582402000452	Ap4A binding site [chemical binding]; other site
582402000453	nudix motif; other site
582402000454	putative metal binding site [ion binding]; other site
582402000455	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
582402000456	NodB motif; other site
582402000457	putative active site [active]
582402000458	putative catalytic site [active]
582402000459	Zn binding site [ion binding]; other site
582402000460	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
582402000461	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
582402000462	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
582402000463	protein binding site [polypeptide binding]; other site
582402000464	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
582402000465	Catalytic dyad [active]
582402000466	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
582402000467	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402000468	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
582402000469	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
582402000470	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
582402000471	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
582402000472	active site
582402000473	(T/H)XGH motif; other site
582402000474	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
582402000475	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
582402000476	putative catalytic cysteine [active]
582402000477	gamma-glutamyl kinase; Provisional; Region: PRK05429
582402000478	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
582402000479	nucleotide binding site [chemical binding]; other site
582402000480	homotetrameric interface [polypeptide binding]; other site
582402000481	putative phosphate binding site [ion binding]; other site
582402000482	putative allosteric binding site; other site
582402000483	PUA domain; Region: PUA; pfam01472
582402000484	GTPase CgtA; Reviewed; Region: obgE; PRK12299
582402000485	GTP1/OBG; Region: GTP1_OBG; pfam01018
582402000486	Obg GTPase; Region: Obg; cd01898
582402000487	G1 box; other site
582402000488	GTP/Mg2+ binding site [chemical binding]; other site
582402000489	Switch I region; other site
582402000490	G2 box; other site
582402000491	G3 box; other site
582402000492	Switch II region; other site
582402000493	G4 box; other site
582402000494	G5 box; other site
582402000495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582402000496	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402000497	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582402000498	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
582402000499	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
582402000500	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
582402000501	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582402000502	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402000503	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
582402000504	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
582402000505	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
582402000506	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
582402000507	putative active site [active]
582402000508	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
582402000509	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
582402000510	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
582402000511	DNA polymerase I; Provisional; Region: PRK05755
582402000512	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
582402000513	active site
582402000514	metal binding site 1 [ion binding]; metal-binding site
582402000515	putative 5' ssDNA interaction site; other site
582402000516	metal binding site 3; metal-binding site
582402000517	metal binding site 2 [ion binding]; metal-binding site
582402000518	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
582402000519	putative DNA binding site [nucleotide binding]; other site
582402000520	putative metal binding site [ion binding]; other site
582402000521	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
582402000522	active site
582402000523	catalytic site [active]
582402000524	substrate binding site [chemical binding]; other site
582402000525	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
582402000526	active site
582402000527	DNA binding site [nucleotide binding]
582402000528	catalytic site [active]
582402000529	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
582402000530	NADH(P)-binding; Region: NAD_binding_10; pfam13460
582402000531	NAD(P) binding site [chemical binding]; other site
582402000532	putative active site [active]
582402000533	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
582402000534	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
582402000535	NAD(P) binding site [chemical binding]; other site
582402000536	catalytic residues [active]
582402000537	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
582402000538	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
582402000539	putative hydrophobic ligand binding site [chemical binding]; other site
582402000540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402000541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402000542	Pneumovirus M2 protein; Region: Pneumo_M2; pfam07380
582402000543	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
582402000544	ArsC family; Region: ArsC; pfam03960
582402000545	catalytic residues [active]
582402000546	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
582402000547	arsenical-resistance protein; Region: acr3; TIGR00832
582402000548	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582402000549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000550	active site
582402000551	phosphorylation site [posttranslational modification]
582402000552	intermolecular recognition site; other site
582402000553	dimerization interface [polypeptide binding]; other site
582402000554	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402000555	DNA binding site [nucleotide binding]
582402000556	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
582402000557	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
582402000558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402000559	dimerization interface [polypeptide binding]; other site
582402000560	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402000561	dimer interface [polypeptide binding]; other site
582402000562	phosphorylation site [posttranslational modification]
582402000563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000564	ATP binding site [chemical binding]; other site
582402000565	Mg2+ binding site [ion binding]; other site
582402000566	G-X-G motif; other site
582402000567	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
582402000568	active pocket/dimerization site; other site
582402000569	active site
582402000570	phosphorylation site [posttranslational modification]
582402000571	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
582402000572	regulatory phosphorylation site [posttranslational modification]; other site
582402000573	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
582402000574	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
582402000575	homotetramer interface [polypeptide binding]; other site
582402000576	ligand binding site [chemical binding]; other site
582402000577	catalytic site [active]
582402000578	NAD binding site [chemical binding]; other site
582402000579	PAS fold; Region: PAS_7; pfam12860
582402000580	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
582402000581	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402000582	dimer interface [polypeptide binding]; other site
582402000583	phosphorylation site [posttranslational modification]
582402000584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000585	ATP binding site [chemical binding]; other site
582402000586	Mg2+ binding site [ion binding]; other site
582402000587	G-X-G motif; other site
582402000588	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
582402000589	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
582402000590	NeuB family; Region: NeuB; pfam03102
582402000591	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
582402000592	NeuB binding interface [polypeptide binding]; other site
582402000593	putative substrate binding site [chemical binding]; other site
582402000594	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
582402000595	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402000596	NAD(P) binding site [chemical binding]; other site
582402000597	active site
582402000598	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
582402000599	ligand binding site; other site
582402000600	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
582402000601	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
582402000602	NAD(P) binding site [chemical binding]; other site
582402000603	homodimer interface [polypeptide binding]; other site
582402000604	substrate binding site [chemical binding]; other site
582402000605	active site
582402000606	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
582402000607	Predicted transcriptional regulators [Transcription]; Region: COG1695
582402000608	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
582402000609	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
582402000610	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
582402000611	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
582402000612	active site
582402000613	dimer interface [polypeptide binding]; other site
582402000614	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
582402000615	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
582402000616	active site
582402000617	FMN binding site [chemical binding]; other site
582402000618	substrate binding site [chemical binding]; other site
582402000619	3Fe-4S cluster binding site [ion binding]; other site
582402000620	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
582402000621	domain interface; other site
582402000622	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
582402000623	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402000624	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402000625	Bacitracin resistance protein BacA; Region: BacA; pfam02673
582402000626	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
582402000627	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
582402000628	putative NAD(P) binding site [chemical binding]; other site
582402000629	active site
582402000630	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402000631	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402000632	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
582402000633	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402000634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000635	active site
582402000636	phosphorylation site [posttranslational modification]
582402000637	intermolecular recognition site; other site
582402000638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000639	Response regulator receiver domain; Region: Response_reg; pfam00072
582402000640	active site
582402000641	phosphorylation site [posttranslational modification]
582402000642	intermolecular recognition site; other site
582402000643	dimerization interface [polypeptide binding]; other site
582402000644	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402000645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402000646	HAMP domain; Region: HAMP; pfam00672
582402000647	dimerization interface [polypeptide binding]; other site
582402000648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402000649	dimer interface [polypeptide binding]; other site
582402000650	phosphorylation site [posttranslational modification]
582402000651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000652	ATP binding site [chemical binding]; other site
582402000653	Mg2+ binding site [ion binding]; other site
582402000654	G-X-G motif; other site
582402000655	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402000656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000657	active site
582402000658	phosphorylation site [posttranslational modification]
582402000659	intermolecular recognition site; other site
582402000660	dimerization interface [polypeptide binding]; other site
582402000661	OpgC protein; Region: OpgC_C; pfam10129
582402000662	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402000663	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
582402000664	Ligand binding site; other site
582402000665	DXD motif; other site
582402000666	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
582402000667	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
582402000668	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402000669	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402000670	DNA binding site [nucleotide binding]
582402000671	domain linker motif; other site
582402000672	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402000673	putative dimerization interface [polypeptide binding]; other site
582402000674	putative ligand binding site [chemical binding]; other site
582402000675	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
582402000676	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
582402000677	catalytic site [active]
582402000678	putative active site [active]
582402000679	putative substrate binding site [chemical binding]; other site
582402000680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
582402000681	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
582402000682	OstA-like protein; Region: OstA; pfam03968
582402000683	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
582402000684	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
582402000685	Walker A/P-loop; other site
582402000686	ATP binding site [chemical binding]; other site
582402000687	Q-loop/lid; other site
582402000688	ABC transporter signature motif; other site
582402000689	Walker B; other site
582402000690	D-loop; other site
582402000691	H-loop/switch region; other site
582402000692	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
582402000693	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
582402000694	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
582402000695	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
582402000696	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
582402000697	30S subunit binding site; other site
582402000698	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
582402000699	active site
582402000700	phosphorylation site [posttranslational modification]
582402000701	hypothetical protein; Provisional; Region: PRK06034
582402000702	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
582402000703	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402000704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402000705	homodimer interface [polypeptide binding]; other site
582402000706	catalytic residue [active]
582402000707	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
582402000708	prephenate dehydrogenase; Validated; Region: PRK08507
582402000709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
582402000710	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
582402000711	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582402000712	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582402000713	putative acyl-acceptor binding pocket; other site
582402000714	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
582402000715	putative active site [active]
582402000716	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
582402000717	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
582402000718	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582402000719	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
582402000720	Walker A/P-loop; other site
582402000721	ATP binding site [chemical binding]; other site
582402000722	Q-loop/lid; other site
582402000723	ABC transporter signature motif; other site
582402000724	Walker B; other site
582402000725	D-loop; other site
582402000726	H-loop/switch region; other site
582402000727	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
582402000728	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
582402000729	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402000730	active site
582402000731	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
582402000732	diaminopimelate decarboxylase; Region: lysA; TIGR01048
582402000733	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
582402000734	active site
582402000735	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402000736	substrate binding site [chemical binding]; other site
582402000737	catalytic residues [active]
582402000738	dimer interface [polypeptide binding]; other site
582402000739	argininosuccinate lyase; Provisional; Region: PRK00855
582402000740	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
582402000741	active sites [active]
582402000742	tetramer interface [polypeptide binding]; other site
582402000743	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
582402000744	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582402000745	catalytic residues [active]
582402000746	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582402000747	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
582402000748	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582402000749	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
582402000750	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
582402000751	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
582402000752	Hemerythrin-like domain; Region: Hr-like; cd12108
582402000753	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
582402000754	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582402000755	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582402000756	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582402000757	Ligand binding site [chemical binding]; other site
582402000758	Electron transfer flavoprotein domain; Region: ETF; pfam01012
582402000759	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
582402000760	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
582402000761	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
582402000762	Cytochrome c; Region: Cytochrom_C; cl11414
582402000763	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582402000764	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402000765	active site
582402000766	Integral membrane protein TerC family; Region: TerC; pfam03741
582402000767	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
582402000768	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
582402000769	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
582402000770	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
582402000771	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
582402000772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402000773	PAS domain; Region: PAS_9; pfam13426
582402000774	putative active site [active]
582402000775	heme pocket [chemical binding]; other site
582402000776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402000777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402000778	dimer interface [polypeptide binding]; other site
582402000779	phosphorylation site [posttranslational modification]
582402000780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000781	ATP binding site [chemical binding]; other site
582402000782	Mg2+ binding site [ion binding]; other site
582402000783	G-X-G motif; other site
582402000784	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402000785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000786	active site
582402000787	phosphorylation site [posttranslational modification]
582402000788	intermolecular recognition site; other site
582402000789	dimerization interface [polypeptide binding]; other site
582402000790	recombinase A; Provisional; Region: recA; PRK09354
582402000791	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
582402000792	hexamer interface [polypeptide binding]; other site
582402000793	Walker A motif; other site
582402000794	ATP binding site [chemical binding]; other site
582402000795	Walker B motif; other site
582402000796	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
582402000797	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
582402000798	motif 1; other site
582402000799	active site
582402000800	motif 2; other site
582402000801	motif 3; other site
582402000802	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
582402000803	DHHA1 domain; Region: DHHA1; pfam02272
582402000804	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582402000805	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
582402000806	active site
582402000807	uracil binding [chemical binding]; other site
582402000808	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
582402000809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402000810	S-adenosylmethionine binding site [chemical binding]; other site
582402000811	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402000812	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
582402000813	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
582402000814	Predicted permeases [General function prediction only]; Region: RarD; COG2962
582402000815	EamA-like transporter family; Region: EamA; cl17759
582402000816	Predicted permeases [General function prediction only]; Region: RarD; COG2962
582402000817	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402000818	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402000819	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
582402000820	ATP binding site [chemical binding]; other site
582402000821	substrate binding site [chemical binding]; other site
582402000822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582402000823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
582402000824	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582402000825	ArsC family; Region: ArsC; pfam03960
582402000826	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402000827	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
582402000828	putative active site [active]
582402000829	putative catalytic site [active]
582402000830	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
582402000831	putative active site [active]
582402000832	putative catalytic site [active]
582402000833	thymidine kinase; Provisional; Region: PRK04296
582402000834	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
582402000835	ATP binding site [chemical binding]; other site
582402000836	Walker A motif; other site
582402000837	Walker B motif; other site
582402000838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402000839	TPR motif; other site
582402000840	binding surface
582402000841	TPR repeat; Region: TPR_11; pfam13414
582402000842	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
582402000843	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
582402000844	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
582402000845	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
582402000846	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
582402000847	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
582402000848	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402000849	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402000850	metal binding site [ion binding]; metal-binding site
582402000851	active site
582402000852	I-site; other site
582402000853	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402000854	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
582402000855	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
582402000856	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402000857	N-terminal plug; other site
582402000858	ligand-binding site [chemical binding]; other site
582402000859	Protein of unknown function (DUF962); Region: DUF962; pfam06127
582402000860	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402000861	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
582402000862	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
582402000863	[2Fe-2S] cluster binding site [ion binding]; other site
582402000864	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
582402000865	hydrophobic ligand binding site; other site
582402000866	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
582402000867	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
582402000868	NAD(P) binding site [chemical binding]; other site
582402000869	Uncharacterized conserved protein [Function unknown]; Region: COG4095
582402000870	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
582402000871	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
582402000872	B12 binding site [chemical binding]; other site
582402000873	cobalt ligand [ion binding]; other site
582402000874	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
582402000875	EamA-like transporter family; Region: EamA; pfam00892
582402000876	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
582402000877	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
582402000878	active site
582402000879	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
582402000880	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
582402000881	DNA binding residues [nucleotide binding]
582402000882	putative dimer interface [polypeptide binding]; other site
582402000883	putative metal binding residues [ion binding]; other site
582402000884	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
582402000885	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
582402000886	diiron binding motif [ion binding]; other site
582402000887	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
582402000888	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
582402000889	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
582402000890	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
582402000891	catalytic triad [active]
582402000892	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
582402000893	Iron-sulfur protein interface; other site
582402000894	proximal quinone binding site [chemical binding]; other site
582402000895	SdhD (CybS) interface [polypeptide binding]; other site
582402000896	proximal heme binding site [chemical binding]; other site
582402000897	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
582402000898	putative SdhC subunit interface [polypeptide binding]; other site
582402000899	putative proximal heme binding site [chemical binding]; other site
582402000900	putative Iron-sulfur protein interface [polypeptide binding]; other site
582402000901	putative proximal quinone binding site; other site
582402000902	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
582402000903	L-aspartate oxidase; Provisional; Region: PRK06175
582402000904	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
582402000905	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
582402000906	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
582402000907	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
582402000908	Uncharacterized conserved protein [Function unknown]; Region: COG5403
582402000909	Uncharacterized conserved protein [Function unknown]; Region: COG1565
582402000910	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
582402000911	Membrane fusogenic activity; Region: BMFP; pfam04380
582402000912	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
582402000913	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
582402000914	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
582402000915	HAMP domain; Region: HAMP; pfam00672
582402000916	dimerization interface [polypeptide binding]; other site
582402000917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
582402000918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000919	ATP binding site [chemical binding]; other site
582402000920	G-X-G motif; other site
582402000921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000922	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
582402000923	active site
582402000924	phosphorylation site [posttranslational modification]
582402000925	intermolecular recognition site; other site
582402000926	dimerization interface [polypeptide binding]; other site
582402000927	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402000928	DNA binding site [nucleotide binding]
582402000929	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402000930	MarR family; Region: MarR_2; pfam12802
582402000931	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
582402000932	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
582402000933	homodimer interface [polypeptide binding]; other site
582402000934	substrate-cofactor binding pocket; other site
582402000935	catalytic residue [active]
582402000936	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
582402000937	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582402000938	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582402000939	short chain dehydrogenase; Provisional; Region: PRK09134
582402000940	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402000941	NAD(P) binding site [chemical binding]; other site
582402000942	active site
582402000943	Dihydroneopterin aldolase; Region: FolB; pfam02152
582402000944	active site
582402000945	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402000946	catalytic core [active]
582402000947	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
582402000948	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
582402000949	active site
582402000950	FMN binding site [chemical binding]; other site
582402000951	substrate binding site [chemical binding]; other site
582402000952	3Fe-4S cluster binding site [ion binding]; other site
582402000953	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
582402000954	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
582402000955	heme binding site [chemical binding]; other site
582402000956	ferroxidase pore; other site
582402000957	ferroxidase diiron center [ion binding]; other site
582402000958	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582402000959	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
582402000960	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582402000961	active site
582402000962	nucleotide binding site [chemical binding]; other site
582402000963	HIGH motif; other site
582402000964	KMSKS motif; other site
582402000965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
582402000966	non-specific DNA binding site [nucleotide binding]; other site
582402000967	salt bridge; other site
582402000968	sequence-specific DNA binding site [nucleotide binding]; other site
582402000969	Predicted transcriptional regulator [Transcription]; Region: COG2932
582402000970	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
582402000971	Catalytic site [active]
582402000972	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402000973	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
582402000974	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
582402000975	active site
582402000976	Zn binding site [ion binding]; other site
582402000977	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582402000978	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582402000979	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402000980	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
582402000981	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
582402000982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402000983	dimer interface [polypeptide binding]; other site
582402000984	phosphorylation site [posttranslational modification]
582402000985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402000986	ATP binding site [chemical binding]; other site
582402000987	Mg2+ binding site [ion binding]; other site
582402000988	G-X-G motif; other site
582402000989	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
582402000990	PhoU domain; Region: PhoU; pfam01895
582402000991	PhoU domain; Region: PhoU; pfam01895
582402000992	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
582402000993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402000994	active site
582402000995	phosphorylation site [posttranslational modification]
582402000996	intermolecular recognition site; other site
582402000997	dimerization interface [polypeptide binding]; other site
582402000998	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402000999	DNA binding site [nucleotide binding]
582402001000	GcrA cell cycle regulator; Region: GcrA; cl11564
582402001001	ABC-2 type transporter; Region: ABC2_membrane; cl17235
582402001002	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
582402001003	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582402001004	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
582402001005	inhibitor-cofactor binding pocket; inhibition site
582402001006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402001007	catalytic residue [active]
582402001008	ornithine carbamoyltransferase; Provisional; Region: PRK00779
582402001009	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
582402001010	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
582402001011	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
582402001012	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
582402001013	dimer interface [polypeptide binding]; other site
582402001014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402001015	catalytic residue [active]
582402001016	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
582402001017	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
582402001018	dimerization interface [polypeptide binding]; other site
582402001019	domain crossover interface; other site
582402001020	redox-dependent activation switch; other site
582402001021	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
582402001022	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
582402001023	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
582402001024	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
582402001025	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582402001026	homodimer interface [polypeptide binding]; other site
582402001027	substrate-cofactor binding pocket; other site
582402001028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402001029	catalytic residue [active]
582402001030	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
582402001031	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
582402001032	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
582402001033	trimer interface [polypeptide binding]; other site
582402001034	active site
582402001035	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
582402001036	trimer interface [polypeptide binding]; other site
582402001037	active site
582402001038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402001039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402001040	non-specific DNA binding site [nucleotide binding]; other site
582402001041	salt bridge; other site
582402001042	sequence-specific DNA binding site [nucleotide binding]; other site
582402001043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402001044	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
582402001045	FeS/SAM binding site; other site
582402001046	MarR family; Region: MarR_2; pfam12802
582402001047	Sporulation related domain; Region: SPOR; pfam05036
582402001048	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
582402001049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402001050	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
582402001051	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
582402001052	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402001053	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582402001054	catalytic residues [active]
582402001055	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
582402001056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402001057	Walker A/P-loop; other site
582402001058	ATP binding site [chemical binding]; other site
582402001059	Q-loop/lid; other site
582402001060	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402001061	ABC transporter signature motif; other site
582402001062	Walker B; other site
582402001063	D-loop; other site
582402001064	ABC transporter; Region: ABC_tran_2; pfam12848
582402001065	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402001066	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
582402001067	active site
582402001068	catalytic residues [active]
582402001069	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
582402001070	TrkA-N domain; Region: TrkA_N; pfam02254
582402001071	putative glutathione S-transferase; Provisional; Region: PRK10357
582402001072	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
582402001073	putative C-terminal domain interface [polypeptide binding]; other site
582402001074	putative GSH binding site (G-site) [chemical binding]; other site
582402001075	putative dimer interface [polypeptide binding]; other site
582402001076	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
582402001077	dimer interface [polypeptide binding]; other site
582402001078	N-terminal domain interface [polypeptide binding]; other site
582402001079	putative substrate binding pocket (H-site) [chemical binding]; other site
582402001080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402001081	Response regulator receiver domain; Region: Response_reg; pfam00072
582402001082	active site
582402001083	phosphorylation site [posttranslational modification]
582402001084	intermolecular recognition site; other site
582402001085	dimerization interface [polypeptide binding]; other site
582402001086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402001087	Response regulator receiver domain; Region: Response_reg; pfam00072
582402001088	active site
582402001089	phosphorylation site [posttranslational modification]
582402001090	intermolecular recognition site; other site
582402001091	dimerization interface [polypeptide binding]; other site
582402001092	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
582402001093	VacJ like lipoprotein; Region: VacJ; cl01073
582402001094	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402001095	dimerization interface [polypeptide binding]; other site
582402001096	putative DNA binding site [nucleotide binding]; other site
582402001097	putative Zn2+ binding site [ion binding]; other site
582402001098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402001099	S-adenosylmethionine binding site [chemical binding]; other site
582402001100	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
582402001101	FAD binding site [chemical binding]; other site
582402001102	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
582402001103	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
582402001104	short chain dehydrogenase; Provisional; Region: PRK06125
582402001105	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
582402001106	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
582402001107	substrate binding pocket [chemical binding]; other site
582402001108	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
582402001109	B12 binding site [chemical binding]; other site
582402001110	cobalt ligand [ion binding]; other site
582402001111	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
582402001112	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
582402001113	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
582402001114	SnoaL-like domain; Region: SnoaL_3; pfam13474
582402001115	Uncharacterized conserved protein [Function unknown]; Region: COG1359
582402001116	Ion transport protein; Region: Ion_trans; pfam00520
582402001117	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
582402001118	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
582402001119	putative metal binding site [ion binding]; other site
582402001120	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582402001121	HSP70 interaction site [polypeptide binding]; other site
582402001122	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
582402001123	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
582402001124	amidase catalytic site [active]
582402001125	Zn binding residues [ion binding]; other site
582402001126	substrate binding site [chemical binding]; other site
582402001127	cell division protein MraZ; Reviewed; Region: PRK00326
582402001128	MraZ protein; Region: MraZ; pfam02381
582402001129	MraZ protein; Region: MraZ; pfam02381
582402001130	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
582402001131	MraW methylase family; Region: Methyltransf_5; cl17771
582402001132	Cell division protein FtsL; Region: FtsL; cl11433
582402001133	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
582402001134	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
582402001135	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582402001136	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
582402001137	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582402001138	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582402001139	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582402001140	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
582402001141	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582402001142	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582402001143	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582402001144	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
582402001145	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
582402001146	Mg++ binding site [ion binding]; other site
582402001147	putative catalytic motif [active]
582402001148	putative substrate binding site [chemical binding]; other site
582402001149	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
582402001150	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
582402001151	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582402001152	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582402001153	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
582402001154	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
582402001155	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
582402001156	active site
582402001157	homodimer interface [polypeptide binding]; other site
582402001158	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
582402001159	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582402001160	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582402001161	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582402001162	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582402001163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582402001164	Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; Region: CY; cl09238
582402001165	Uncharacterized conserved protein [Function unknown]; Region: COG2128
582402001166	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
582402001167	GTPase RsgA; Reviewed; Region: PRK01889
582402001168	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
582402001169	GTPase/Zn-binding domain interface [polypeptide binding]; other site
582402001170	GTP/Mg2+ binding site [chemical binding]; other site
582402001171	G4 box; other site
582402001172	G5 box; other site
582402001173	G1 box; other site
582402001174	Switch I region; other site
582402001175	G2 box; other site
582402001176	G3 box; other site
582402001177	Switch II region; other site
582402001178	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
582402001179	FAD binding domain; Region: FAD_binding_4; pfam01565
582402001180	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
582402001181	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402001182	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
582402001183	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
582402001184	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582402001185	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
582402001186	Cell division protein FtsQ; Region: FtsQ; pfam03799
582402001187	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
582402001188	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
582402001189	nucleotide binding site [chemical binding]; other site
582402001190	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
582402001191	Cell division protein FtsA; Region: FtsA; pfam14450
582402001192	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
582402001193	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
582402001194	nucleotide binding site [chemical binding]; other site
582402001195	SulA interaction site; other site
582402001196	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
582402001197	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
582402001198	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
582402001199	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
582402001200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402001201	Walker A/P-loop; other site
582402001202	ATP binding site [chemical binding]; other site
582402001203	Q-loop/lid; other site
582402001204	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
582402001205	ABC transporter signature motif; other site
582402001206	Walker B; other site
582402001207	D-loop; other site
582402001208	H-loop/switch region; other site
582402001209	Ligase N family; Region: LIGANc; smart00532
582402001210	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
582402001211	nucleotide binding pocket [chemical binding]; other site
582402001212	K-X-D-G motif; other site
582402001213	catalytic site [active]
582402001214	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
582402001215	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
582402001216	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
582402001217	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
582402001218	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
582402001219	Dimer interface [polypeptide binding]; other site
582402001220	BRCT sequence motif; other site
582402001221	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
582402001222	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
582402001223	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
582402001224	active site
582402001225	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
582402001226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402001227	S-adenosylmethionine binding site [chemical binding]; other site
582402001228	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
582402001229	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402001230	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402001231	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402001232	Phytase; Region: Phytase; cl17685
582402001233	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582402001234	GIY-YIG motif/motif A; other site
582402001235	putative active site [active]
582402001236	putative metal binding site [ion binding]; other site
582402001237	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
582402001238	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
582402001239	Part of AAA domain; Region: AAA_19; pfam13245
582402001240	Family description; Region: UvrD_C_2; pfam13538
582402001241	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
582402001242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402001243	motif II; other site
582402001244	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
582402001245	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
582402001246	Cl- selectivity filter; other site
582402001247	Cl- binding residues [ion binding]; other site
582402001248	pore gating glutamate residue; other site
582402001249	dimer interface [polypeptide binding]; other site
582402001250	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
582402001251	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
582402001252	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
582402001253	putative active site [active]
582402001254	putative FMN binding site [chemical binding]; other site
582402001255	putative substrate binding site [chemical binding]; other site
582402001256	putative catalytic residue [active]
582402001257	Tetratricopeptide repeat; Region: TPR_16; pfam13432
582402001258	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
582402001259	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
582402001260	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402001261	active site
582402001262	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
582402001263	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
582402001264	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
582402001265	DNA binding site [nucleotide binding]
582402001266	active site
582402001267	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
582402001268	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
582402001269	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582402001270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582402001271	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
582402001272	AlkA N-terminal domain; Region: AlkA_N; pfam06029
582402001273	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582402001274	minor groove reading motif; other site
582402001275	helix-hairpin-helix signature motif; other site
582402001276	substrate binding pocket [chemical binding]; other site
582402001277	active site
582402001278	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
582402001279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402001280	S-adenosylmethionine binding site [chemical binding]; other site
582402001281	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
582402001282	fumarate hydratase; Reviewed; Region: fumC; PRK00485
582402001283	Class II fumarases; Region: Fumarase_classII; cd01362
582402001284	active site
582402001285	tetramer interface [polypeptide binding]; other site
582402001286	OsmC-like protein; Region: OsmC; cl00767
582402001287	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
582402001288	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
582402001289	Stringent starvation protein B; Region: SspB; cl01120
582402001290	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
582402001291	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582402001292	homodimer interface [polypeptide binding]; other site
582402001293	substrate-cofactor binding pocket; other site
582402001294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402001295	catalytic residue [active]
582402001296	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
582402001297	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402001298	putative metal binding site [ion binding]; other site
582402001299	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402001300	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402001301	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
582402001302	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
582402001303	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
582402001304	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582402001305	Dienelactone hydrolase family; Region: DLH; pfam01738
582402001306	thymidylate synthase; Reviewed; Region: thyA; PRK01827
582402001307	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
582402001308	dimerization interface [polypeptide binding]; other site
582402001309	active site
582402001310	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
582402001311	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
582402001312	folate binding site [chemical binding]; other site
582402001313	NADP+ binding site [chemical binding]; other site
582402001314	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
582402001315	active site
582402001316	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
582402001317	Domain of unknown function DUF59; Region: DUF59; pfam01883
582402001318	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
582402001319	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
582402001320	Walker A motif; other site
582402001321	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
582402001322	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
582402001323	HflK protein; Region: hflK; TIGR01933
582402001324	HflC protein; Region: hflC; TIGR01932
582402001325	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
582402001326	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582402001327	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582402001328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582402001329	protein binding site [polypeptide binding]; other site
582402001330	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
582402001331	protein binding site [polypeptide binding]; other site
582402001332	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402001333	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402001334	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
582402001335	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
582402001336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402001337	motif II; other site
582402001338	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
582402001339	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
582402001340	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
582402001341	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
582402001342	PYR/PP interface [polypeptide binding]; other site
582402001343	dimer interface [polypeptide binding]; other site
582402001344	TPP binding site [chemical binding]; other site
582402001345	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
582402001346	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
582402001347	TPP-binding site [chemical binding]; other site
582402001348	dimer interface [polypeptide binding]; other site
582402001349	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
582402001350	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
582402001351	putative valine binding site [chemical binding]; other site
582402001352	dimer interface [polypeptide binding]; other site
582402001353	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
582402001354	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
582402001355	ketol-acid reductoisomerase; Provisional; Region: PRK05479
582402001356	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
582402001357	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
582402001358	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
582402001359	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
582402001360	Uncharacterized conserved protein [Function unknown]; Region: COG0398
582402001361	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
582402001362	2-isopropylmalate synthase; Validated; Region: PRK00915
582402001363	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
582402001364	active site
582402001365	catalytic residues [active]
582402001366	metal binding site [ion binding]; metal-binding site
582402001367	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
582402001368	putative outer membrane lipoprotein; Provisional; Region: PRK10510
582402001369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582402001370	ligand binding site [chemical binding]; other site
582402001371	enterobactin exporter EntS; Provisional; Region: PRK10489
582402001372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402001373	putative substrate translocation pore; other site
582402001374	rod shape-determining protein MreB; Provisional; Region: PRK13927
582402001375	MreB and similar proteins; Region: MreB_like; cd10225
582402001376	nucleotide binding site [chemical binding]; other site
582402001377	Mg binding site [ion binding]; other site
582402001378	putative protofilament interaction site [polypeptide binding]; other site
582402001379	RodZ interaction site [polypeptide binding]; other site
582402001380	rod shape-determining protein MreC; Provisional; Region: PRK13922
582402001381	rod shape-determining protein MreC; Region: MreC; pfam04085
582402001382	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
582402001383	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
582402001384	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582402001385	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
582402001386	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
582402001387	Na2 binding site [ion binding]; other site
582402001388	putative substrate binding site 1 [chemical binding]; other site
582402001389	Na binding site 1 [ion binding]; other site
582402001390	putative substrate binding site 2 [chemical binding]; other site
582402001391	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
582402001392	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
582402001393	TAP-like protein; Region: Abhydrolase_4; pfam08386
582402001394	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
582402001395	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
582402001396	Permease; Region: Permease; pfam02405
582402001397	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
582402001398	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
582402001399	Walker A/P-loop; other site
582402001400	ATP binding site [chemical binding]; other site
582402001401	Q-loop/lid; other site
582402001402	ABC transporter signature motif; other site
582402001403	Walker B; other site
582402001404	D-loop; other site
582402001405	H-loop/switch region; other site
582402001406	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
582402001407	mce related protein; Region: MCE; pfam02470
582402001408	Protein of unknown function (DUF330); Region: DUF330; cl01135
582402001409	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
582402001410	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402001411	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582402001412	putative binding surface; other site
582402001413	active site
582402001414	Chorismate mutase type II; Region: CM_2; smart00830
582402001415	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
582402001416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402001417	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
582402001418	dimerization interface [polypeptide binding]; other site
582402001419	substrate binding pocket [chemical binding]; other site
582402001420	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
582402001421	active site
582402001422	SAM binding site [chemical binding]; other site
582402001423	homodimer interface [polypeptide binding]; other site
582402001424	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
582402001425	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402001426	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
582402001427	putative C-terminal domain interface [polypeptide binding]; other site
582402001428	putative GSH binding site (G-site) [chemical binding]; other site
582402001429	putative dimer interface [polypeptide binding]; other site
582402001430	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582402001431	N-terminal domain interface [polypeptide binding]; other site
582402001432	dimer interface [polypeptide binding]; other site
582402001433	substrate binding pocket (H-site) [chemical binding]; other site
582402001434	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
582402001435	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582402001436	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582402001437	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
582402001438	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
582402001439	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582402001440	Active Sites [active]
582402001441	tellurium resistance terB-like protein; Region: terB_like; cd07177
582402001442	metal binding site [ion binding]; metal-binding site
582402001443	Autoinducer binding domain; Region: Autoind_bind; pfam03472
582402001444	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582402001445	DNA binding residues [nucleotide binding]
582402001446	dimerization interface [polypeptide binding]; other site
582402001447	signal recognition particle protein; Provisional; Region: PRK10867
582402001448	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
582402001449	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582402001450	P loop; other site
582402001451	GTP binding site [chemical binding]; other site
582402001452	Signal peptide binding domain; Region: SRP_SPB; pfam02978
582402001453	chorismate mutase; Provisional; Region: PRK09239
582402001454	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
582402001455	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582402001456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402001457	Coenzyme A binding pocket [chemical binding]; other site
582402001458	RimM N-terminal domain; Region: RimM; pfam01782
582402001459	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
582402001460	inner membrane transporter YjeM; Provisional; Region: PRK15238
582402001461	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
582402001462	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
582402001463	Ligand binding site; other site
582402001464	Putative Catalytic site; other site
582402001465	DXD motif; other site
582402001466	TIR domain; Region: TIR_2; pfam13676
582402001467	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
582402001468	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
582402001469	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
582402001470	AbgT putative transporter family; Region: ABG_transport; cl17431
582402001471	Rod binding protein; Region: Rod-binding; cl01626
582402001472	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
582402001473	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
582402001474	Class II flagellar assembly regulator; Region: FliX; pfam10768
582402001475	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
582402001476	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
582402001477	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
582402001478	SAF-like; Region: SAF_2; pfam13144
582402001479	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
582402001480	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
582402001481	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582402001482	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582402001483	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
582402001484	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582402001485	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
582402001486	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
582402001487	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
582402001488	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
582402001489	Uncharacterized conserved protein [Function unknown]; Region: COG3334
582402001490	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
582402001491	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
582402001492	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
582402001493	tetramer interface [polypeptide binding]; other site
582402001494	heme binding pocket [chemical binding]; other site
582402001495	NADPH binding site [chemical binding]; other site
582402001496	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
582402001497	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402001498	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402001499	dimer interface [polypeptide binding]; other site
582402001500	putative CheW interface [polypeptide binding]; other site
582402001501	Protein of unknown function, DUF393; Region: DUF393; pfam04134
582402001502	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
582402001503	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
582402001504	Ligand Binding Site [chemical binding]; other site
582402001505	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
582402001506	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
582402001507	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
582402001508	PA/protease or protease-like domain interface [polypeptide binding]; other site
582402001509	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
582402001510	metal binding site [ion binding]; metal-binding site
582402001511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402001512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402001513	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582402001514	dimerization interface [polypeptide binding]; other site
582402001515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402001516	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582402001517	active site
582402001518	metal binding site [ion binding]; metal-binding site
582402001519	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
582402001520	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
582402001521	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
582402001522	Na binding site [ion binding]; other site
582402001523	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
582402001524	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
582402001525	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
582402001526	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
582402001527	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582402001528	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
582402001529	RDD family; Region: RDD; pfam06271
582402001530	TIR domain; Region: TIR_2; pfam13676
582402001531	Domain of unknown function (DUF389); Region: DUF389; cl00781
582402001532	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402001533	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
582402001534	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582402001535	Methyltransferase domain; Region: Methyltransf_12; pfam08242
582402001536	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
582402001537	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
582402001538	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582402001539	inhibitor-cofactor binding pocket; inhibition site
582402001540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402001541	catalytic residue [active]
582402001542	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
582402001543	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
582402001544	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402001545	catalytic residue [active]
582402001546	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
582402001547	AAA domain; Region: AAA_26; pfam13500
582402001548	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
582402001549	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
582402001550	apolar tunnel; other site
582402001551	heme binding site [chemical binding]; other site
582402001552	dimerization interface [polypeptide binding]; other site
582402001553	Predicted flavoprotein [General function prediction only]; Region: COG0431
582402001554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582402001555	Protein of unknown function, DUF481; Region: DUF481; pfam04338
582402001556	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
582402001557	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
582402001558	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402001559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402001560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402001561	ABC transporter signature motif; other site
582402001562	Walker B; other site
582402001563	ABC transporter; Region: ABC_tran_2; pfam12848
582402001564	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402001565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402001566	metal binding site [ion binding]; metal-binding site
582402001567	active site
582402001568	I-site; other site
582402001569	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402001570	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582402001571	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
582402001572	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
582402001573	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
582402001574	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
582402001575	putative substrate binding pocket [chemical binding]; other site
582402001576	trimer interface [polypeptide binding]; other site
582402001577	isocitrate dehydrogenase; Validated; Region: PRK08299
582402001578	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
582402001579	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582402001580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402001581	S-adenosylmethionine binding site [chemical binding]; other site
582402001582	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
582402001583	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
582402001584	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
582402001585	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
582402001586	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
582402001587	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
582402001588	Predicted transcriptional regulator [Transcription]; Region: COG2378
582402001589	HTH domain; Region: HTH_11; pfam08279
582402001590	WYL domain; Region: WYL; pfam13280
582402001591	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402001592	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
582402001593	putative N-terminal domain interface [polypeptide binding]; other site
582402001594	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
582402001595	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
582402001596	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402001597	RNA binding surface [nucleotide binding]; other site
582402001598	Methyltransferase domain; Region: Methyltransf_24; pfam13578
582402001599	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
582402001600	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
582402001601	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402001602	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402001603	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
582402001604	Zn binding site [ion binding]; other site
582402001605	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
582402001606	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
582402001607	Nitrate and nitrite sensing; Region: NIT; pfam08376
582402001608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402001609	dimerization interface [polypeptide binding]; other site
582402001610	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402001611	dimer interface [polypeptide binding]; other site
582402001612	putative CheW interface [polypeptide binding]; other site
582402001613	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
582402001614	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582402001615	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402001616	FeS/SAM binding site; other site
582402001617	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
582402001618	putative GSH binding site [chemical binding]; other site
582402001619	catalytic residues [active]
582402001620	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582402001621	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582402001622	active site
582402001623	catalytic tetrad [active]
582402001624	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
582402001625	Uncharacterized conserved protein [Function unknown]; Region: COG1359
582402001626	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
582402001627	active site
582402001628	Zn binding site [ion binding]; other site
582402001629	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
582402001630	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
582402001631	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
582402001632	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
582402001633	dimerization interface [polypeptide binding]; other site
582402001634	ATP binding site [chemical binding]; other site
582402001635	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
582402001636	dimerization interface [polypeptide binding]; other site
582402001637	ATP binding site [chemical binding]; other site
582402001638	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
582402001639	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
582402001640	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
582402001641	putative active site [active]
582402001642	catalytic triad [active]
582402001643	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
582402001644	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
582402001645	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
582402001646	ATP binding site [chemical binding]; other site
582402001647	active site
582402001648	substrate binding site [chemical binding]; other site
582402001649	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
582402001650	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
582402001651	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582402001652	catalytic residues [active]
582402001653	adenylosuccinate lyase; Provisional; Region: PRK07492
582402001654	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
582402001655	tetramer interface [polypeptide binding]; other site
582402001656	active site
582402001657	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
582402001658	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402001659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402001660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402001661	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
582402001662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402001663	NAD(P) binding site [chemical binding]; other site
582402001664	active site
582402001665	hypothetical protein; Reviewed; Region: PRK00024
582402001666	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
582402001667	MPN+ (JAMM) motif; other site
582402001668	Zinc-binding site [ion binding]; other site
582402001669	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
582402001670	active site
582402001671	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
582402001672	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
582402001673	putative MPT binding site; other site
582402001674	Cupin-like domain; Region: Cupin_8; pfam13621
582402001675	integrase; Provisional; Region: PRK09692
582402001676	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582402001677	active site
582402001678	Int/Topo IB signature motif; other site
582402001679	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
582402001680	hypothetical protein; Region: PHA01755
582402001681	Methyltransferase domain; Region: Methyltransf_26; pfam13659
582402001682	KilA-N domain; Region: KilA-N; pfam04383
582402001683	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582402001684	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402001685	ATP binding site [chemical binding]; other site
582402001686	putative Mg++ binding site [ion binding]; other site
582402001687	Pseudomurein-binding repeat; Region: PMBR; pfam09373
582402001688	T5orf172 domain; Region: T5orf172; pfam10544
582402001689	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
582402001690	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582402001691	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582402001692	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402001693	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582402001694	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
582402001695	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
582402001696	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
582402001697	putative metal binding site [ion binding]; other site
582402001698	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
582402001699	Interdomain contacts; other site
582402001700	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
582402001701	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
582402001702	hexamer interface [polypeptide binding]; other site
582402001703	ligand binding site [chemical binding]; other site
582402001704	putative active site [active]
582402001705	NAD(P) binding site [chemical binding]; other site
582402001706	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
582402001707	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
582402001708	putative FMN binding site [chemical binding]; other site
582402001709	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
582402001710	ADP-ribose binding site [chemical binding]; other site
582402001711	dimer interface [polypeptide binding]; other site
582402001712	active site
582402001713	nudix motif; other site
582402001714	metal binding site [ion binding]; metal-binding site
582402001715	serine acetyltransferase; Provisional; Region: cysE; PRK11132
582402001716	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
582402001717	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
582402001718	trimer interface [polypeptide binding]; other site
582402001719	active site
582402001720	substrate binding site [chemical binding]; other site
582402001721	CoA binding site [chemical binding]; other site
582402001722	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
582402001723	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582402001724	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582402001725	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582402001726	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582402001727	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582402001728	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582402001729	PhoH-like protein; Region: PhoH; pfam02562
582402001730	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
582402001731	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
582402001732	trimer interface [polypeptide binding]; other site
582402001733	putative metal binding site [ion binding]; other site
582402001734	homoserine O-succinyltransferase; Provisional; Region: PRK05368
582402001735	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
582402001736	proposed active site lysine [active]
582402001737	conserved cys residue [active]
582402001738	PilZ domain; Region: PilZ; pfam07238
582402001739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
582402001740	PAS domain; Region: PAS_5; pfam07310
582402001741	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
582402001742	Short C-terminal domain; Region: SHOCT; pfam09851
582402001743	Antirestriction protein (ArdA); Region: ArdA; cl01953
582402001744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402001745	sequence-specific DNA binding site [nucleotide binding]; other site
582402001746	salt bridge; other site
582402001747	Protein of unknown function (DUF736); Region: DUF736; pfam05284
582402001748	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
582402001749	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
582402001750	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
582402001751	VirB7 interaction site; other site
582402001752	conjugal transfer protein TrbF; Provisional; Region: PRK13872
582402001753	VirB8 protein; Region: VirB8; cl01500
582402001754	conjugal transfer protein TrbL; Provisional; Region: PRK13875
582402001755	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
582402001756	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
582402001757	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
582402001758	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
582402001759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402001760	Walker A/P-loop; other site
582402001761	ATP binding site [chemical binding]; other site
582402001762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402001763	Walker B; other site
582402001764	D-loop; other site
582402001765	H-loop/switch region; other site
582402001766	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
582402001767	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
582402001768	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
582402001769	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
582402001770	ATP binding site [chemical binding]; other site
582402001771	Walker A motif; other site
582402001772	hexamer interface [polypeptide binding]; other site
582402001773	Walker B motif; other site
582402001774	RES domain; Region: RES; smart00953
582402001775	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
582402001776	HicB family; Region: HicB; pfam05534
582402001777	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
582402001778	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
582402001779	Walker A motif; other site
582402001780	ATP binding site [chemical binding]; other site
582402001781	Walker B motif; other site
582402001782	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582402001783	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
582402001784	DNA binding residues [nucleotide binding]
582402001785	Domain of unknown function (DUF955); Region: DUF955; pfam06114
582402001786	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
582402001787	Part of AAA domain; Region: AAA_19; pfam13245
582402001788	Family description; Region: UvrD_C_2; pfam13538
582402001789	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
582402001790	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
582402001791	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
582402001792	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
582402001793	hypothetical protein; Provisional; Region: PRK06153
582402001794	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
582402001795	ATP binding site [chemical binding]; other site
582402001796	substrate interface [chemical binding]; other site
582402001797	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
582402001798	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
582402001799	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
582402001800	Helix-turn-helix domain; Region: HTH_17; pfam12728
582402001801	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
582402001802	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
582402001803	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
582402001804	DNA binding residues [nucleotide binding]
582402001805	dimer interface [polypeptide binding]; other site
582402001806	putative metal binding site [ion binding]; other site
582402001807	MerT mercuric transport protein; Region: MerT; cl03578
582402001808	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
582402001809	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
582402001810	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
582402001811	DNA binding residues [nucleotide binding]
582402001812	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
582402001813	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582402001814	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
582402001815	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402001816	Outer membrane efflux protein; Region: OEP; pfam02321
582402001817	CopC domain; Region: CopC; pfam04234
582402001818	Copper resistance protein D; Region: CopD; pfam05425
582402001819	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
582402001820	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
582402001821	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
582402001822	Multicopper oxidase; Region: Cu-oxidase; pfam00394
582402001823	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
582402001824	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
582402001825	dimer interface [polypeptide binding]; other site
582402001826	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
582402001827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402001828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402001829	DNA binding residues [nucleotide binding]
582402001830	EamA-like transporter family; Region: EamA; pfam00892
582402001831	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
582402001832	EamA-like transporter family; Region: EamA; pfam00892
582402001833	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
582402001834	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
582402001835	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
582402001836	Predicted metal-binding protein [General function prediction only]; Region: COG3019
582402001837	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
582402001838	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582402001839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402001840	motif II; other site
582402001841	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402001842	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
582402001843	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
582402001844	SnoaL-like domain; Region: SnoaL_3; pfam13474
582402001845	Integrase core domain; Region: rve; pfam00665
582402001846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
582402001847	Integrase core domain; Region: rve_3; pfam13683
582402001848	Outer membrane efflux protein; Region: OEP; pfam02321
582402001849	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582402001850	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
582402001851	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402001852	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582402001853	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
582402001854	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582402001855	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
582402001856	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
582402001857	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582402001858	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
582402001859	active site
582402001860	DNA binding site [nucleotide binding]
582402001861	Int/Topo IB signature motif; other site
582402001862	BCCT family transporter; Region: BCCT; pfam02028
582402001863	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402001864	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
582402001865	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402001866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402001867	binding surface
582402001868	TPR motif; other site
582402001869	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
582402001870	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402001871	TPR motif; other site
582402001872	binding surface
582402001873	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402001874	TPR motif; other site
582402001875	binding surface
582402001876	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
582402001877	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582402001878	MarR family; Region: MarR; pfam01047
582402001879	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
582402001880	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582402001881	Predicted acetyltransferase [General function prediction only]; Region: COG3153
582402001882	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582402001883	metal ion-dependent adhesion site (MIDAS); other site
582402001884	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
582402001885	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
582402001886	conserved cys residue [active]
582402001887	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
582402001888	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582402001889	Protein of unknown function DUF58; Region: DUF58; pfam01882
582402001890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402001891	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
582402001892	Walker A motif; other site
582402001893	ATP binding site [chemical binding]; other site
582402001894	Walker B motif; other site
582402001895	arginine finger; other site
582402001896	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
582402001897	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
582402001898	putative active site [active]
582402001899	putative CoA binding site [chemical binding]; other site
582402001900	nudix motif; other site
582402001901	metal binding site [ion binding]; metal-binding site
582402001902	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
582402001903	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
582402001904	active site
582402001905	NTP binding site [chemical binding]; other site
582402001906	metal binding triad [ion binding]; metal-binding site
582402001907	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
582402001908	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
582402001909	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
582402001910	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
582402001911	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
582402001912	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
582402001913	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
582402001914	[2Fe-2S] cluster binding site [ion binding]; other site
582402001915	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
582402001916	cytochrome b; Provisional; Region: CYTB; MTH00156
582402001917	Qi binding site; other site
582402001918	intrachain domain interface; other site
582402001919	interchain domain interface [polypeptide binding]; other site
582402001920	heme bH binding site [chemical binding]; other site
582402001921	heme bL binding site [chemical binding]; other site
582402001922	Qo binding site; other site
582402001923	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
582402001924	interchain domain interface [polypeptide binding]; other site
582402001925	intrachain domain interface; other site
582402001926	Qi binding site; other site
582402001927	Qo binding site; other site
582402001928	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
582402001929	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
582402001930	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
582402001931	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402001932	putative C-terminal domain interface [polypeptide binding]; other site
582402001933	putative GSH binding site (G-site) [chemical binding]; other site
582402001934	putative dimer interface [polypeptide binding]; other site
582402001935	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
582402001936	putative substrate binding pocket (H-site) [chemical binding]; other site
582402001937	putative N-terminal domain interface [polypeptide binding]; other site
582402001938	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582402001939	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582402001940	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402001941	active site
582402001942	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
582402001943	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
582402001944	oligomer interface [polypeptide binding]; other site
582402001945	active site residues [active]
582402001946	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
582402001947	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
582402001948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402001949	putative substrate translocation pore; other site
582402001950	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
582402001951	nitrilase; Region: PLN02798
582402001952	putative active site [active]
582402001953	catalytic triad [active]
582402001954	dimer interface [polypeptide binding]; other site
582402001955	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582402001956	GTP-binding protein YchF; Reviewed; Region: PRK09601
582402001957	YchF GTPase; Region: YchF; cd01900
582402001958	G1 box; other site
582402001959	GTP/Mg2+ binding site [chemical binding]; other site
582402001960	Switch I region; other site
582402001961	G2 box; other site
582402001962	Switch II region; other site
582402001963	G3 box; other site
582402001964	G4 box; other site
582402001965	G5 box; other site
582402001966	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
582402001967	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
582402001968	putative active site [active]
582402001969	catalytic residue [active]
582402001970	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
582402001971	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
582402001972	5S rRNA interface [nucleotide binding]; other site
582402001973	CTC domain interface [polypeptide binding]; other site
582402001974	L16 interface [polypeptide binding]; other site
582402001975	Penicillinase repressor; Region: Pencillinase_R; cl17580
582402001976	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
582402001977	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402001978	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402001979	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
582402001980	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
582402001981	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402001982	active site
582402001983	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
582402001984	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
582402001985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
582402001986	Family of unknown function (DUF490); Region: DUF490; pfam04357
582402001987	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
582402001988	Surface antigen; Region: Bac_surface_Ag; pfam01103
582402001989	Staphylococcal nuclease homologues; Region: SNc; smart00318
582402001990	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
582402001991	Catalytic site; other site
582402001992	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
582402001993	Ferredoxin [Energy production and conversion]; Region: COG1146
582402001994	4Fe-4S binding domain; Region: Fer4; pfam00037
582402001995	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
582402001996	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402001997	RNA binding surface [nucleotide binding]; other site
582402001998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582402001999	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
582402002000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402002001	nucleotide binding region [chemical binding]; other site
582402002002	ATP-binding site [chemical binding]; other site
582402002003	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
582402002004	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
582402002005	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402002006	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402002007	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402002008	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402002009	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
582402002010	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
582402002011	active site 2 [active]
582402002012	active site 1 [active]
582402002013	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582402002014	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
582402002015	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582402002016	active site
582402002017	DNA binding site [nucleotide binding]
582402002018	Int/Topo IB signature motif; other site
582402002019	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
582402002020	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
582402002021	ADP binding site [chemical binding]; other site
582402002022	magnesium binding site [ion binding]; other site
582402002023	putative shikimate binding site; other site
582402002024	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
582402002025	active site
582402002026	dimer interface [polypeptide binding]; other site
582402002027	metal binding site [ion binding]; metal-binding site
582402002028	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
582402002029	Domain of unknown function DUF21; Region: DUF21; pfam01595
582402002030	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582402002031	Transporter associated domain; Region: CorC_HlyC; smart01091
582402002032	Autoinducer binding domain; Region: Autoind_bind; pfam03472
582402002033	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582402002034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582402002035	DNA binding residues [nucleotide binding]
582402002036	dimerization interface [polypeptide binding]; other site
582402002037	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
582402002038	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582402002039	HSP70 interaction site [polypeptide binding]; other site
582402002040	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
582402002041	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
582402002042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582402002043	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
582402002044	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
582402002045	metal ion-dependent adhesion site (MIDAS); other site
582402002046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
582402002047	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
582402002048	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
582402002049	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
582402002050	Protein of unknown function, DUF481; Region: DUF481; pfam04338
582402002051	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
582402002052	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
582402002053	SEC-C motif; Region: SEC-C; pfam02810
582402002054	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
582402002055	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
582402002056	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
582402002057	heterotetramer interface [polypeptide binding]; other site
582402002058	active site pocket [active]
582402002059	cleavage site
582402002060	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
582402002061	active site
582402002062	8-oxo-dGMP binding site [chemical binding]; other site
582402002063	nudix motif; other site
582402002064	metal binding site [ion binding]; metal-binding site
582402002065	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
582402002066	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
582402002067	Methyltransferase domain; Region: Methyltransf_11; pfam08241
582402002068	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
582402002069	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402002070	active site
582402002071	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
582402002072	GSH binding site [chemical binding]; other site
582402002073	catalytic residues [active]
582402002074	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
582402002075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
582402002076	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
582402002077	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
582402002078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402002079	S-adenosylmethionine binding site [chemical binding]; other site
582402002080	aspartate kinase; Reviewed; Region: PRK06635
582402002081	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
582402002082	putative nucleotide binding site [chemical binding]; other site
582402002083	putative catalytic residues [active]
582402002084	putative Mg ion binding site [ion binding]; other site
582402002085	putative aspartate binding site [chemical binding]; other site
582402002086	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
582402002087	putative allosteric regulatory site; other site
582402002088	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
582402002089	putative allosteric regulatory residue; other site
582402002090	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
582402002091	GAF domain; Region: GAF; pfam01590
582402002092	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
582402002093	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
582402002094	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
582402002095	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
582402002096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402002097	non-specific DNA binding site [nucleotide binding]; other site
582402002098	salt bridge; other site
582402002099	sequence-specific DNA binding site [nucleotide binding]; other site
582402002100	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
582402002101	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
582402002102	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
582402002103	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
582402002104	CoenzymeA binding site [chemical binding]; other site
582402002105	subunit interaction site [polypeptide binding]; other site
582402002106	PHB binding site; other site
582402002107	MAPEG family; Region: MAPEG; pfam01124
582402002108	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402002109	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402002110	metal binding site [ion binding]; metal-binding site
582402002111	active site
582402002112	I-site; other site
582402002113	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402002114	peptide chain release factor 1; Validated; Region: prfA; PRK00591
582402002115	This domain is found in peptide chain release factors; Region: PCRF; smart00937
582402002116	RF-1 domain; Region: RF-1; pfam00472
582402002117	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
582402002118	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
582402002119	MOSC domain; Region: MOSC; pfam03473
582402002120	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
582402002121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402002122	S-adenosylmethionine binding site [chemical binding]; other site
582402002123	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
582402002124	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
582402002125	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
582402002126	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
582402002127	dimer interface [polypeptide binding]; other site
582402002128	active site
582402002129	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402002130	catalytic residues [active]
582402002131	substrate binding site [chemical binding]; other site
582402002132	Heavy-metal-associated domain; Region: HMA; pfam00403
582402002133	metal-binding site [ion binding]
582402002134	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
582402002135	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
582402002136	NAD(P) binding pocket [chemical binding]; other site
582402002137	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
582402002138	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
582402002139	dimer interface [polypeptide binding]; other site
582402002140	active site
582402002141	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402002142	catalytic residues [active]
582402002143	substrate binding site [chemical binding]; other site
582402002144	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
582402002145	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402002146	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
582402002147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
582402002148	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
582402002149	Class I ribonucleotide reductase; Region: RNR_I; cd01679
582402002150	active site
582402002151	dimer interface [polypeptide binding]; other site
582402002152	catalytic residues [active]
582402002153	effector binding site; other site
582402002154	R2 peptide binding site; other site
582402002155	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
582402002156	dimer interface [polypeptide binding]; other site
582402002157	putative radical transfer pathway; other site
582402002158	diiron center [ion binding]; other site
582402002159	tyrosyl radical; other site
582402002160	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
582402002161	AMP nucleosidase; Provisional; Region: PRK08292
582402002162	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
582402002163	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
582402002164	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402002165	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582402002166	Cytochrome P450; Region: p450; cl12078
582402002167	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
582402002168	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
582402002169	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
582402002170	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582402002171	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
582402002172	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
582402002173	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
582402002174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402002175	catalytic residue [active]
582402002176	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582402002177	TadE-like protein; Region: TadE; pfam07811
582402002178	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582402002179	TadE-like protein; Region: TadE; pfam07811
582402002180	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
582402002181	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
582402002182	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
582402002183	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
582402002184	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
582402002185	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
582402002186	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
582402002187	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
582402002188	Type IV pili component [Cell motility and secretion]; Region: COG5461
582402002189	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
582402002190	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
582402002191	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
582402002192	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
582402002193	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
582402002194	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
582402002195	ATP binding site [chemical binding]; other site
582402002196	Walker A motif; other site
582402002197	hexamer interface [polypeptide binding]; other site
582402002198	Walker B motif; other site
582402002199	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
582402002200	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582402002201	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
582402002202	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582402002203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002204	TPR motif; other site
582402002205	binding surface
582402002206	TPR repeat; Region: TPR_11; pfam13414
582402002207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002208	binding surface
582402002209	TPR motif; other site
582402002210	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
582402002211	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
582402002212	interface (dimer of trimers) [polypeptide binding]; other site
582402002213	Substrate-binding/catalytic site; other site
582402002214	Zn-binding sites [ion binding]; other site
582402002215	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402002216	MarR family; Region: MarR; pfam01047
582402002217	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
582402002218	NlpC/P60 family; Region: NLPC_P60; pfam00877
582402002219	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582402002220	prephenate dehydratase; Provisional; Region: PRK11899
582402002221	Prephenate dehydratase; Region: PDT; pfam00800
582402002222	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
582402002223	putative L-Phe binding site [chemical binding]; other site
582402002224	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
582402002225	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
582402002226	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
582402002227	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
582402002228	putative NADH binding site [chemical binding]; other site
582402002229	putative active site [active]
582402002230	nudix motif; other site
582402002231	putative metal binding site [ion binding]; other site
582402002232	TIR domain; Region: TIR_2; pfam13676
582402002233	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
582402002234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402002235	Walker A motif; other site
582402002236	ATP binding site [chemical binding]; other site
582402002237	Walker B motif; other site
582402002238	arginine finger; other site
582402002239	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
582402002240	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
582402002241	hypothetical protein; Validated; Region: PRK00153
582402002242	recombination protein RecR; Reviewed; Region: recR; PRK00076
582402002243	RecR protein; Region: RecR; pfam02132
582402002244	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
582402002245	putative active site [active]
582402002246	putative metal-binding site [ion binding]; other site
582402002247	tetramer interface [polypeptide binding]; other site
582402002248	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
582402002249	RmuC family; Region: RmuC; pfam02646
582402002250	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
582402002251	active site
582402002252	catalytic residues [active]
582402002253	metal binding site [ion binding]; metal-binding site
582402002254	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
582402002255	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
582402002256	putative active site [active]
582402002257	substrate binding site [chemical binding]; other site
582402002258	putative cosubstrate binding site; other site
582402002259	catalytic site [active]
582402002260	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
582402002261	substrate binding site [chemical binding]; other site
582402002262	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
582402002263	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
582402002264	dimerization interface 3.5A [polypeptide binding]; other site
582402002265	active site
582402002266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402002267	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582402002268	S-adenosylmethionine binding site [chemical binding]; other site
582402002269	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582402002270	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
582402002271	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
582402002272	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
582402002273	trimer interface [polypeptide binding]; other site
582402002274	active site
582402002275	substrate binding site [chemical binding]; other site
582402002276	CoA binding site [chemical binding]; other site
582402002277	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
582402002278	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
582402002279	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
582402002280	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
582402002281	feedback inhibition sensing region; other site
582402002282	homohexameric interface [polypeptide binding]; other site
582402002283	nucleotide binding site [chemical binding]; other site
582402002284	N-acetyl-L-glutamate binding site [chemical binding]; other site
582402002285	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
582402002286	UGMP family protein; Provisional; Region: PRK14878
582402002287	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
582402002288	G1 box; other site
582402002289	GTP/Mg2+ binding site [chemical binding]; other site
582402002290	Switch I region; other site
582402002291	G2 box; other site
582402002292	G3 box; other site
582402002293	Switch II region; other site
582402002294	G4 box; other site
582402002295	G5 box; other site
582402002296	membrane protein insertase; Provisional; Region: PRK01318
582402002297	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
582402002298	Ribonuclease P; Region: Ribonuclease_P; pfam00825
582402002299	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
582402002300	Protein of unknown function DUF262; Region: DUF262; pfam03235
582402002301	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
582402002302	Protein of unknown function, DUF547; Region: DUF547; pfam04784
582402002303	Uncharacterized conserved protein [Function unknown]; Region: COG0398
582402002304	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
582402002305	mercuric reductase; Validated; Region: PRK06370
582402002306	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402002307	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402002308	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582402002309	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582402002310	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402002311	dimer interface [polypeptide binding]; other site
582402002312	phosphorylation site [posttranslational modification]
582402002313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402002314	ATP binding site [chemical binding]; other site
582402002315	Mg2+ binding site [ion binding]; other site
582402002316	G-X-G motif; other site
582402002317	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
582402002318	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
582402002319	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
582402002320	putative active site pocket [active]
582402002321	cleavage site
582402002322	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582402002323	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402002324	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402002325	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402002326	Response regulator receiver domain; Region: Response_reg; pfam00072
582402002327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002328	active site
582402002329	phosphorylation site [posttranslational modification]
582402002330	intermolecular recognition site; other site
582402002331	dimerization interface [polypeptide binding]; other site
582402002332	CHASE domain; Region: CHASE; pfam03924
582402002333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402002334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402002335	dimer interface [polypeptide binding]; other site
582402002336	phosphorylation site [posttranslational modification]
582402002337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402002338	ATP binding site [chemical binding]; other site
582402002339	Mg2+ binding site [ion binding]; other site
582402002340	G-X-G motif; other site
582402002341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402002342	dimer interface [polypeptide binding]; other site
582402002343	phosphorylation site [posttranslational modification]
582402002344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402002345	ATP binding site [chemical binding]; other site
582402002346	Mg2+ binding site [ion binding]; other site
582402002347	G-X-G motif; other site
582402002348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
582402002349	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582402002350	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582402002351	substrate binding site [chemical binding]; other site
582402002352	ligand binding site [chemical binding]; other site
582402002353	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
582402002354	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402002355	active site
582402002356	motif I; other site
582402002357	motif II; other site
582402002358	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
582402002359	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
582402002360	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
582402002361	putative active site [active]
582402002362	putative substrate binding site [chemical binding]; other site
582402002363	putative cosubstrate binding site; other site
582402002364	catalytic site [active]
582402002365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402002366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402002367	putative substrate translocation pore; other site
582402002368	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
582402002369	Protein of unknown function (DUF952); Region: DUF952; pfam06108
582402002370	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
582402002371	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
582402002372	quinone interaction residues [chemical binding]; other site
582402002373	active site
582402002374	catalytic residues [active]
582402002375	FMN binding site [chemical binding]; other site
582402002376	substrate binding site [chemical binding]; other site
582402002377	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
582402002378	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
582402002379	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
582402002380	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
582402002381	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
582402002382	putative active site [active]
582402002383	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
582402002384	Zn binding site [ion binding]; other site
582402002385	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582402002386	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
582402002387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402002388	ATP binding site [chemical binding]; other site
582402002389	ATP binding site [chemical binding]; other site
582402002390	putative Mg++ binding site [ion binding]; other site
582402002391	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402002392	nucleotide binding region [chemical binding]; other site
582402002393	ATP-binding site [chemical binding]; other site
582402002394	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
582402002395	HRDC domain; Region: HRDC; pfam00570
582402002396	HPP family; Region: HPP; pfam04982
582402002397	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
582402002398	FOG: CBS domain [General function prediction only]; Region: COG0517
582402002399	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
582402002400	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
582402002401	dimer interface [polypeptide binding]; other site
582402002402	Alkaline phosphatase homologues; Region: alkPPc; smart00098
582402002403	active site
582402002404	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402002405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002406	active site
582402002407	phosphorylation site [posttranslational modification]
582402002408	intermolecular recognition site; other site
582402002409	dimerization interface [polypeptide binding]; other site
582402002410	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402002411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002412	active site
582402002413	phosphorylation site [posttranslational modification]
582402002414	intermolecular recognition site; other site
582402002415	dimerization interface [polypeptide binding]; other site
582402002416	Conserved TM helix; Region: TM_helix; pfam05552
582402002417	mechanosensitive channel MscS; Provisional; Region: PRK10334
582402002418	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582402002419	Trypsin; Region: Trypsin; pfam00089
582402002420	active site
582402002421	substrate binding sites [chemical binding]; other site
582402002422	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
582402002423	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
582402002424	active site
582402002425	zinc binding site [ion binding]; other site
582402002426	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402002427	Serine hydrolase; Region: Ser_hydrolase; cl17834
582402002428	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
582402002429	active site
582402002430	Zn binding site [ion binding]; other site
582402002431	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
582402002432	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402002433	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582402002434	Sel1-like repeats; Region: SEL1; smart00671
582402002435	Sel1-like repeats; Region: SEL1; smart00671
582402002436	Sel1-like repeats; Region: SEL1; smart00671
582402002437	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402002438	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
582402002439	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
582402002440	DNA binding residues [nucleotide binding]
582402002441	putative dimer interface [polypeptide binding]; other site
582402002442	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
582402002443	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
582402002444	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402002445	active site
582402002446	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
582402002447	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
582402002448	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
582402002449	dimer interface [polypeptide binding]; other site
582402002450	active site
582402002451	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
582402002452	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402002453	substrate binding site [chemical binding]; other site
582402002454	oxyanion hole (OAH) forming residues; other site
582402002455	trimer interface [polypeptide binding]; other site
582402002456	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
582402002457	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
582402002458	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582402002459	Ligand Binding Site [chemical binding]; other site
582402002460	Predicted membrane protein [Function unknown]; Region: COG3650
582402002461	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
582402002462	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
582402002463	cofactor binding site; other site
582402002464	DNA binding site [nucleotide binding]
582402002465	substrate interaction site [chemical binding]; other site
582402002466	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
582402002467	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
582402002468	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
582402002469	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
582402002470	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582402002471	catalytic residues [active]
582402002472	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402002473	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
582402002474	C-terminal domain interface [polypeptide binding]; other site
582402002475	GSH binding site (G-site) [chemical binding]; other site
582402002476	dimer interface [polypeptide binding]; other site
582402002477	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582402002478	N-terminal domain interface [polypeptide binding]; other site
582402002479	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
582402002480	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
582402002481	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582402002482	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
582402002483	catalytic site [active]
582402002484	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
582402002485	active site 2 [active]
582402002486	active site 1 [active]
582402002487	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
582402002488	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582402002489	metal binding site 2 [ion binding]; metal-binding site
582402002490	putative DNA binding helix; other site
582402002491	metal binding site 1 [ion binding]; metal-binding site
582402002492	dimer interface [polypeptide binding]; other site
582402002493	structural Zn2+ binding site [ion binding]; other site
582402002494	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
582402002495	von Willebrand factor; Region: vWF_A; pfam12450
582402002496	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
582402002497	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
582402002498	metal ion-dependent adhesion site (MIDAS); other site
582402002499	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
582402002500	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
582402002501	SapC; Region: SapC; pfam07277
582402002502	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
582402002503	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
582402002504	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
582402002505	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
582402002506	DsbD alpha interface [polypeptide binding]; other site
582402002507	catalytic residues [active]
582402002508	histidyl-tRNA synthetase; Region: hisS; TIGR00442
582402002509	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
582402002510	dimer interface [polypeptide binding]; other site
582402002511	motif 1; other site
582402002512	motif 2; other site
582402002513	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402002514	active site
582402002515	motif 3; other site
582402002516	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
582402002517	anticodon binding site; other site
582402002518	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
582402002519	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402002520	active site
582402002521	dimer interface [polypeptide binding]; other site
582402002522	motif 2; other site
582402002523	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402002524	active site
582402002525	motif 3; other site
582402002526	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
582402002527	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
582402002528	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
582402002529	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
582402002530	active site
582402002531	catalytic site [active]
582402002532	PhoD-like phosphatase; Region: PhoD; pfam09423
582402002533	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
582402002534	putative active site [active]
582402002535	putative metal binding site [ion binding]; other site
582402002536	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
582402002537	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402002538	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402002539	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402002540	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
582402002541	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
582402002542	ring oligomerisation interface [polypeptide binding]; other site
582402002543	ATP/Mg binding site [chemical binding]; other site
582402002544	stacking interactions; other site
582402002545	hinge regions; other site
582402002546	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
582402002547	oligomerisation interface [polypeptide binding]; other site
582402002548	mobile loop; other site
582402002549	roof hairpin; other site
582402002550	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
582402002551	HAMP domain; Region: HAMP; pfam00672
582402002552	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402002553	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402002554	dimer interface [polypeptide binding]; other site
582402002555	putative CheW interface [polypeptide binding]; other site
582402002556	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402002557	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
582402002558	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582402002559	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402002560	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
582402002561	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
582402002562	Predicted membrane protein [Function unknown]; Region: COG2311
582402002563	Protein of unknown function (DUF418); Region: DUF418; cl12135
582402002564	Protein of unknown function (DUF418); Region: DUF418; pfam04235
582402002565	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
582402002566	dimer interface [polypeptide binding]; other site
582402002567	putative tRNA-binding site [nucleotide binding]; other site
582402002568	Protein of unknown function DUF262; Region: DUF262; pfam03235
582402002569	Uncharacterized conserved protein [Function unknown]; Region: COG1479
582402002570	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
582402002571	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582402002572	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402002573	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
582402002574	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402002575	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
582402002576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402002577	active site
582402002578	motif I; other site
582402002579	motif II; other site
582402002580	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
582402002581	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
582402002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002583	active site
582402002584	phosphorylation site [posttranslational modification]
582402002585	intermolecular recognition site; other site
582402002586	dimerization interface [polypeptide binding]; other site
582402002587	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
582402002588	dimer interaction site [polypeptide binding]; other site
582402002589	substrate-binding tunnel; other site
582402002590	active site
582402002591	catalytic site [active]
582402002592	substrate binding site [chemical binding]; other site
582402002593	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
582402002594	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
582402002595	active site
582402002596	Riboflavin kinase; Region: Flavokinase; pfam01687
582402002597	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
582402002598	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582402002599	active site
582402002600	HIGH motif; other site
582402002601	nucleotide binding site [chemical binding]; other site
582402002602	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
582402002603	active site
582402002604	KMSKS motif; other site
582402002605	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
582402002606	tRNA binding surface [nucleotide binding]; other site
582402002607	anticodon binding site; other site
582402002608	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
582402002609	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
582402002610	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
582402002611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402002612	ATP binding site [chemical binding]; other site
582402002613	Mg2+ binding site [ion binding]; other site
582402002614	G-X-G motif; other site
582402002615	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
582402002616	ATP binding site [chemical binding]; other site
582402002617	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
582402002618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
582402002619	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
582402002620	RNA/DNA hybrid binding site [nucleotide binding]; other site
582402002621	active site
582402002622	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
582402002623	BON domain; Region: BON; pfam04972
582402002624	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582402002625	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582402002626	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402002627	putative Zn2+ binding site [ion binding]; other site
582402002628	putative DNA binding site [nucleotide binding]; other site
582402002629	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582402002630	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402002631	Coenzyme A binding pocket [chemical binding]; other site
582402002632	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
582402002633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402002634	S-adenosylmethionine binding site [chemical binding]; other site
582402002635	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
582402002636	nucleoside/Zn binding site; other site
582402002637	dimer interface [polypeptide binding]; other site
582402002638	catalytic motif [active]
582402002639	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582402002640	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402002641	RNA binding surface [nucleotide binding]; other site
582402002642	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
582402002643	active site
582402002644	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
582402002645	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
582402002646	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
582402002647	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
582402002648	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
582402002649	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
582402002650	generic binding surface II; other site
582402002651	generic binding surface I; other site
582402002652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
582402002653	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402002654	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402002655	Beta-Casp domain; Region: Beta-Casp; cl12567
582402002656	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
582402002657	putative acyl-acceptor binding pocket; other site
582402002658	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
582402002659	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
582402002660	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
582402002661	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
582402002662	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
582402002663	putative acyl-acceptor binding pocket; other site
582402002664	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
582402002665	Putative phosphatase (DUF442); Region: DUF442; cl17385
582402002666	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
582402002667	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
582402002668	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402002669	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
582402002670	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582402002671	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
582402002672	active site
582402002673	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
582402002674	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582402002675	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402002676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402002677	Walker A/P-loop; other site
582402002678	ATP binding site [chemical binding]; other site
582402002679	Q-loop/lid; other site
582402002680	ABC transporter signature motif; other site
582402002681	Walker B; other site
582402002682	D-loop; other site
582402002683	H-loop/switch region; other site
582402002684	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
582402002685	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
582402002686	catalytic residues [active]
582402002687	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
582402002688	SelR domain; Region: SelR; pfam01641
582402002689	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
582402002690	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
582402002691	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
582402002692	UbiA prenyltransferase family; Region: UbiA; pfam01040
582402002693	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
582402002694	RNA methyltransferase, RsmE family; Region: TIGR00046
582402002695	glutamate--cysteine ligase; Region: PLN02611
582402002696	Aspartyl protease; Region: Asp_protease_2; pfam13650
582402002697	inhibitor binding site; inhibition site
582402002698	catalytic motif [active]
582402002699	Catalytic residue [active]
582402002700	Active site flap [active]
582402002701	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582402002702	catalytic motif [active]
582402002703	Catalytic residue [active]
582402002704	POT family; Region: PTR2; cl17359
582402002705	POT family; Region: PTR2; cl17359
582402002706	protease TldD; Provisional; Region: tldD; PRK10735
582402002707	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117
582402002708	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
582402002709	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
582402002710	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
582402002711	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
582402002712	Subunit I/III interface [polypeptide binding]; other site
582402002713	D-pathway; other site
582402002714	Subunit I/VIIc interface [polypeptide binding]; other site
582402002715	Subunit I/IV interface [polypeptide binding]; other site
582402002716	Subunit I/II interface [polypeptide binding]; other site
582402002717	Low-spin heme (heme a) binding site [chemical binding]; other site
582402002718	Subunit I/VIIa interface [polypeptide binding]; other site
582402002719	Subunit I/VIa interface [polypeptide binding]; other site
582402002720	Dimer interface; other site
582402002721	Putative water exit pathway; other site
582402002722	Binuclear center (heme a3/CuB) [ion binding]; other site
582402002723	K-pathway; other site
582402002724	Subunit I/Vb interface [polypeptide binding]; other site
582402002725	Putative proton exit pathway; other site
582402002726	Subunit I/VIb interface; other site
582402002727	Subunit I/VIc interface [polypeptide binding]; other site
582402002728	Electron transfer pathway; other site
582402002729	Subunit I/VIIIb interface [polypeptide binding]; other site
582402002730	Subunit I/VIIb interface [polypeptide binding]; other site
582402002731	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
582402002732	UbiA prenyltransferase family; Region: UbiA; pfam01040
582402002733	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
582402002734	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
582402002735	Subunit III/VIIa interface [polypeptide binding]; other site
582402002736	Phospholipid binding site [chemical binding]; other site
582402002737	Subunit I/III interface [polypeptide binding]; other site
582402002738	Subunit III/VIb interface [polypeptide binding]; other site
582402002739	Subunit III/VIa interface; other site
582402002740	Subunit III/Vb interface [polypeptide binding]; other site
582402002741	Protein of unknown function (DUF983); Region: DUF983; cl02211
582402002742	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
582402002743	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
582402002744	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
582402002745	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402002746	catalytic residue [active]
582402002747	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582402002748	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582402002749	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582402002750	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402002751	Putative transcriptional regulator [Transcription]; Region: COG1678
582402002752	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
582402002753	catalytic triad [active]
582402002754	dimer interface [polypeptide binding]; other site
582402002755	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
582402002756	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
582402002757	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
582402002758	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
582402002759	active site 1 [active]
582402002760	dimer interface [polypeptide binding]; other site
582402002761	hexamer interface [polypeptide binding]; other site
582402002762	active site 2 [active]
582402002763	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
582402002764	glutathionine S-transferase; Provisional; Region: PRK10542
582402002765	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
582402002766	C-terminal domain interface [polypeptide binding]; other site
582402002767	GSH binding site (G-site) [chemical binding]; other site
582402002768	dimer interface [polypeptide binding]; other site
582402002769	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
582402002770	dimer interface [polypeptide binding]; other site
582402002771	N-terminal domain interface [polypeptide binding]; other site
582402002772	substrate binding pocket (H-site) [chemical binding]; other site
582402002773	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402002774	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402002775	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
582402002776	RNA/DNA hybrid binding site [nucleotide binding]; other site
582402002777	active site
582402002778	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
582402002779	RNA/DNA hybrid binding site [nucleotide binding]; other site
582402002780	active site
582402002781	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
582402002782	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
582402002783	putative active site [active]
582402002784	putative substrate binding site [chemical binding]; other site
582402002785	ATP binding site [chemical binding]; other site
582402002786	hypothetical protein; Provisional; Region: PRK09272
582402002787	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402002788	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
582402002789	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
582402002790	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
582402002791	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
582402002792	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582402002793	active site
582402002794	HIGH motif; other site
582402002795	nucleotide binding site [chemical binding]; other site
582402002796	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
582402002797	KMSK motif region; other site
582402002798	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
582402002799	tRNA binding surface [nucleotide binding]; other site
582402002800	anticodon binding site; other site
582402002801	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
582402002802	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582402002803	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
582402002804	lipoyl attachment site [posttranslational modification]; other site
582402002805	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
582402002806	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
582402002807	tetramer interface [polypeptide binding]; other site
582402002808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402002809	catalytic residue [active]
582402002810	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
582402002811	tetramer interface [polypeptide binding]; other site
582402002812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402002813	catalytic residue [active]
582402002814	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
582402002815	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
582402002816	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
582402002817	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
582402002818	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
582402002819	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
582402002820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
582402002821	AAA domain; Region: AAA_23; pfam13476
582402002822	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
582402002823	Walker A/P-loop; other site
582402002824	ATP binding site [chemical binding]; other site
582402002825	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
582402002826	ABC transporter signature motif; other site
582402002827	Walker B; other site
582402002828	D-loop; other site
582402002829	H-loop/switch region; other site
582402002830	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
582402002831	Thioredoxin; Region: Thioredoxin_4; pfam13462
582402002832	Protein of unknown function (DUF721); Region: DUF721; pfam05258
582402002833	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
582402002834	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582402002835	minor groove reading motif; other site
582402002836	helix-hairpin-helix signature motif; other site
582402002837	substrate binding pocket [chemical binding]; other site
582402002838	active site
582402002839	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
582402002840	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
582402002841	DNA binding and oxoG recognition site [nucleotide binding]
582402002842	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402002843	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402002844	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402002845	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
582402002846	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
582402002847	DNA methylase; Region: N6_N4_Mtase; pfam01555
582402002848	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
582402002849	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402002850	FeS/SAM binding site; other site
582402002851	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
582402002852	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
582402002853	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
582402002854	Probable Catalytic site; other site
582402002855	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582402002856	GAF domain; Region: GAF; pfam01590
582402002857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402002858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402002859	dimer interface [polypeptide binding]; other site
582402002860	phosphorylation site [posttranslational modification]
582402002861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402002862	ATP binding site [chemical binding]; other site
582402002863	Mg2+ binding site [ion binding]; other site
582402002864	G-X-G motif; other site
582402002865	Response regulator receiver domain; Region: Response_reg; pfam00072
582402002866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002867	active site
582402002868	phosphorylation site [posttranslational modification]
582402002869	intermolecular recognition site; other site
582402002870	dimerization interface [polypeptide binding]; other site
582402002871	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
582402002872	Fe-S cluster binding site [ion binding]; other site
582402002873	active site
582402002874	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
582402002875	hydroxyglutarate oxidase; Provisional; Region: PRK11728
582402002876	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
582402002877	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
582402002878	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
582402002879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002880	binding surface
582402002881	TPR motif; other site
582402002882	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582402002883	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
582402002884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002885	TPR motif; other site
582402002886	binding surface
582402002887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002888	TPR motif; other site
582402002889	binding surface
582402002890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402002891	binding surface
582402002892	TPR motif; other site
582402002893	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
582402002894	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
582402002895	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
582402002896	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
582402002897	Mg++ binding site [ion binding]; other site
582402002898	putative catalytic motif [active]
582402002899	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
582402002900	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582402002901	substrate binding pocket [chemical binding]; other site
582402002902	chain length determination region; other site
582402002903	substrate-Mg2+ binding site; other site
582402002904	catalytic residues [active]
582402002905	aspartate-rich region 1; other site
582402002906	active site lid residues [active]
582402002907	aspartate-rich region 2; other site
582402002908	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
582402002909	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
582402002910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402002911	Serine hydrolase; Region: Ser_hydrolase; pfam06821
582402002912	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402002913	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
582402002914	dimer interface [polypeptide binding]; other site
582402002915	FMN binding site [chemical binding]; other site
582402002916	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402002917	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402002918	dimerization interface [polypeptide binding]; other site
582402002919	putative DNA binding site [nucleotide binding]; other site
582402002920	putative Zn2+ binding site [ion binding]; other site
582402002921	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
582402002922	putative acetyltransferase YhhY; Provisional; Region: PRK10140
582402002923	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582402002924	Coenzyme A binding pocket [chemical binding]; other site
582402002925	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
582402002926	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
582402002927	GIY-YIG motif/motif A; other site
582402002928	active site
582402002929	catalytic site [active]
582402002930	putative DNA binding site [nucleotide binding]; other site
582402002931	metal binding site [ion binding]; metal-binding site
582402002932	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
582402002933	Response regulator receiver domain; Region: Response_reg; pfam00072
582402002934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002935	active site
582402002936	phosphorylation site [posttranslational modification]
582402002937	intermolecular recognition site; other site
582402002938	dimerization interface [polypeptide binding]; other site
582402002939	Response regulator receiver domain; Region: Response_reg; pfam00072
582402002940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402002941	active site
582402002942	phosphorylation site [posttranslational modification]
582402002943	intermolecular recognition site; other site
582402002944	dimerization interface [polypeptide binding]; other site
582402002945	aspartate aminotransferase; Provisional; Region: PRK05764
582402002946	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402002947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402002948	homodimer interface [polypeptide binding]; other site
582402002949	catalytic residue [active]
582402002950	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
582402002951	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
582402002952	PhnA protein; Region: PhnA; pfam03831
582402002953	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
582402002954	active site
582402002955	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
582402002956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
582402002957	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
582402002958	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402002959	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
582402002960	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
582402002961	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
582402002962	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
582402002963	dimerization interface [polypeptide binding]; other site
582402002964	DPS ferroxidase diiron center [ion binding]; other site
582402002965	ion pore; other site
582402002966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402002967	non-specific DNA binding site [nucleotide binding]; other site
582402002968	salt bridge; other site
582402002969	sequence-specific DNA binding site [nucleotide binding]; other site
582402002970	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
582402002971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402002972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402002973	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582402002974	putative effector binding pocket; other site
582402002975	dimerization interface [polypeptide binding]; other site
582402002976	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
582402002977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402002978	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402002979	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
582402002980	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
582402002981	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
582402002982	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
582402002983	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
582402002984	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
582402002985	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
582402002986	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402002987	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582402002988	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
582402002989	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402002990	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582402002991	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
582402002992	IMP binding site; other site
582402002993	dimer interface [polypeptide binding]; other site
582402002994	interdomain contacts; other site
582402002995	partial ornithine binding site; other site
582402002996	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582402002997	Peptidase family M48; Region: Peptidase_M48; pfam01435
582402002998	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582402002999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402003000	putative CheW interface [polypeptide binding]; other site
582402003001	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
582402003002	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
582402003003	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
582402003004	catalytic site [active]
582402003005	subunit interface [polypeptide binding]; other site
582402003006	Yqey-like protein; Region: YqeY; cl17540
582402003007	DNA primase; Validated; Region: dnaG; PRK05667
582402003008	CHC2 zinc finger; Region: zf-CHC2; cl17510
582402003009	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
582402003010	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
582402003011	active site
582402003012	metal binding site [ion binding]; metal-binding site
582402003013	interdomain interaction site; other site
582402003014	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
582402003015	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
582402003016	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
582402003017	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582402003018	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
582402003019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402003020	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
582402003021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402003022	DNA binding residues [nucleotide binding]
582402003023	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
582402003024	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
582402003025	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582402003026	GIY-YIG motif/motif A; other site
582402003027	putative active site [active]
582402003028	putative metal binding site [ion binding]; other site
582402003029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402003030	non-specific DNA binding site [nucleotide binding]; other site
582402003031	salt bridge; other site
582402003032	sequence-specific DNA binding site [nucleotide binding]; other site
582402003033	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
582402003034	motif 1; other site
582402003035	dimer interface [polypeptide binding]; other site
582402003036	active site
582402003037	motif 2; other site
582402003038	motif 3; other site
582402003039	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
582402003040	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
582402003041	pyruvate phosphate dikinase; Provisional; Region: PRK09279
582402003042	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
582402003043	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
582402003044	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
582402003045	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
582402003046	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
582402003047	Phospholipid methyltransferase; Region: PEMT; cl17370
582402003048	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402003049	DNA binding site [nucleotide binding]
582402003050	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582402003051	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
582402003052	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
582402003053	dimerization interface [polypeptide binding]; other site
582402003054	active site
582402003055	L-aspartate oxidase; Provisional; Region: PRK07512
582402003056	L-aspartate oxidase; Provisional; Region: PRK06175
582402003057	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
582402003058	quinolinate synthetase; Provisional; Region: PRK09375
582402003059	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402003060	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
582402003061	active site
582402003062	catalytic triad [active]
582402003063	oxyanion hole [active]
582402003064	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
582402003065	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
582402003066	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
582402003067	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
582402003068	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
582402003069	Ion channel; Region: Ion_trans_2; pfam07885
582402003070	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402003071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402003072	dimer interface [polypeptide binding]; other site
582402003073	phosphorylation site [posttranslational modification]
582402003074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003075	ATP binding site [chemical binding]; other site
582402003076	Mg2+ binding site [ion binding]; other site
582402003077	G-X-G motif; other site
582402003078	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402003079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402003080	active site
582402003081	phosphorylation site [posttranslational modification]
582402003082	intermolecular recognition site; other site
582402003083	dimerization interface [polypeptide binding]; other site
582402003084	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
582402003085	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
582402003086	FAD binding domain; Region: FAD_binding_4; pfam01565
582402003087	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
582402003088	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
582402003089	TrkA-N domain; Region: TrkA_N; pfam02254
582402003090	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
582402003091	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
582402003092	putative catalytic residue [active]
582402003093	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
582402003094	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
582402003095	putative NAD(P) binding site [chemical binding]; other site
582402003096	active site
582402003097	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402003098	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402003099	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
582402003100	putative metal binding site [ion binding]; other site
582402003101	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582402003102	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402003103	RNA binding surface [nucleotide binding]; other site
582402003104	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
582402003105	active site
582402003106	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582402003107	DNA-binding site [nucleotide binding]; DNA binding site
582402003108	RNA-binding motif; other site
582402003109	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
582402003110	putative active site [active]
582402003111	putative ligand binding site [chemical binding]; other site
582402003112	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262
582402003113	putative NAD(P) binding site [chemical binding]; other site
582402003114	hypothetical protein; Validated; Region: PRK02101
582402003115	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
582402003116	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
582402003117	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
582402003118	YceI-like domain; Region: YceI; pfam04264
582402003119	Uncharacterized conserved protein [Function unknown]; Region: COG2353
582402003120	Uncharacterized conserved protein [Function unknown]; Region: COG2353
582402003121	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582402003122	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582402003123	active site
582402003124	catalytic tetrad [active]
582402003125	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
582402003126	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
582402003127	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
582402003128	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
582402003129	putative NAD(P) binding site [chemical binding]; other site
582402003130	putative substrate binding site [chemical binding]; other site
582402003131	catalytic Zn binding site [ion binding]; other site
582402003132	structural Zn binding site [ion binding]; other site
582402003133	dimer interface [polypeptide binding]; other site
582402003134	TIR domain; Region: TIR_2; pfam13676
582402003135	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582402003136	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402003137	P-loop; other site
582402003138	Magnesium ion binding site [ion binding]; other site
582402003139	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402003140	Magnesium ion binding site [ion binding]; other site
582402003141	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
582402003142	EamA-like transporter family; Region: EamA; pfam00892
582402003143	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
582402003144	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
582402003145	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582402003146	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
582402003147	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
582402003148	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582402003149	Catalytic site [active]
582402003150	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
582402003151	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582402003152	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
582402003153	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582402003154	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
582402003155	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
582402003156	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
582402003157	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582402003158	substrate binding pocket [chemical binding]; other site
582402003159	chain length determination region; other site
582402003160	substrate-Mg2+ binding site; other site
582402003161	catalytic residues [active]
582402003162	aspartate-rich region 1; other site
582402003163	active site lid residues [active]
582402003164	aspartate-rich region 2; other site
582402003165	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
582402003166	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
582402003167	TPP-binding site; other site
582402003168	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582402003169	PYR/PP interface [polypeptide binding]; other site
582402003170	dimer interface [polypeptide binding]; other site
582402003171	TPP binding site [chemical binding]; other site
582402003172	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582402003173	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
582402003174	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582402003175	Coenzyme A binding pocket [chemical binding]; other site
582402003176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003177	S-adenosylmethionine binding site [chemical binding]; other site
582402003178	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
582402003179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402003180	RNA binding surface [nucleotide binding]; other site
582402003181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003182	S-adenosylmethionine binding site [chemical binding]; other site
582402003183	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
582402003184	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
582402003185	Tetramer interface [polypeptide binding]; other site
582402003186	active site
582402003187	FMN-binding site [chemical binding]; other site
582402003188	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
582402003189	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
582402003190	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
582402003191	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402003192	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
582402003193	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
582402003194	putative active site [active]
582402003195	catalytic site [active]
582402003196	putative metal binding site [ion binding]; other site
582402003197	oligomer interface [polypeptide binding]; other site
582402003198	putative acyl-CoA synthetase; Provisional; Region: PRK06018
582402003199	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
582402003200	dimer interface [polypeptide binding]; other site
582402003201	acyl-activating enzyme (AAE) consensus motif; other site
582402003202	putative active site [active]
582402003203	AMP binding site [chemical binding]; other site
582402003204	putative CoA binding site [chemical binding]; other site
582402003205	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
582402003206	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582402003207	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327
582402003208	Putative phosphatase (DUF442); Region: DUF442; cl17385
582402003209	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
582402003210	tandem repeat interface [polypeptide binding]; other site
582402003211	oligomer interface [polypeptide binding]; other site
582402003212	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
582402003213	active site residues [active]
582402003214	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
582402003215	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
582402003216	oligomer interface [polypeptide binding]; other site
582402003217	tandem repeat interface [polypeptide binding]; other site
582402003218	active site residues [active]
582402003219	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
582402003220	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
582402003221	GTP binding site; other site
582402003222	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
582402003223	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
582402003224	dimer interface [polypeptide binding]; other site
582402003225	putative functional site; other site
582402003226	putative MPT binding site; other site
582402003227	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
582402003228	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582402003229	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582402003230	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
582402003231	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
582402003232	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
582402003233	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
582402003234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
582402003235	TPR motif; other site
582402003236	binding surface
582402003237	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402003238	TPR motif; other site
582402003239	binding surface
582402003240	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
582402003241	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402003242	methionine sulfoxide reductase B; Provisional; Region: PRK00222
582402003243	SelR domain; Region: SelR; pfam01641
582402003244	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
582402003245	putative active site [active]
582402003246	putative catalytic site [active]
582402003247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
582402003248	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
582402003249	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
582402003250	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
582402003251	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
582402003252	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507
582402003253	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
582402003254	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
582402003255	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
582402003256	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
582402003257	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
582402003258	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402003259	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
582402003260	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402003261	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
582402003262	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402003263	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
582402003264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
582402003265	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
582402003266	DnaA box-binding interface [nucleotide binding]; other site
582402003267	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
582402003268	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402003269	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402003270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402003271	dimer interface [polypeptide binding]; other site
582402003272	phosphorylation site [posttranslational modification]
582402003273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003274	ATP binding site [chemical binding]; other site
582402003275	Mg2+ binding site [ion binding]; other site
582402003276	G-X-G motif; other site
582402003277	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
582402003278	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
582402003279	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
582402003280	G1 box; other site
582402003281	putative GEF interaction site [polypeptide binding]; other site
582402003282	GTP/Mg2+ binding site [chemical binding]; other site
582402003283	Switch I region; other site
582402003284	G2 box; other site
582402003285	G3 box; other site
582402003286	Switch II region; other site
582402003287	G4 box; other site
582402003288	G5 box; other site
582402003289	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
582402003290	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
582402003291	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
582402003292	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582402003293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
582402003294	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
582402003295	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
582402003296	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402003297	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582402003298	Transglycosylase; Region: Transgly; pfam00912
582402003299	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
582402003300	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
582402003301	Uncharacterized conserved protein [Function unknown]; Region: COG5484
582402003302	Uncharacterized conserved protein [Function unknown]; Region: COG5323
582402003303	Terminase-like family; Region: Terminase_6; pfam03237
582402003304	Phage-related protein [Function unknown]; Region: COG4695
582402003305	Phage portal protein; Region: Phage_portal; pfam04860
582402003306	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
582402003307	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
582402003308	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
582402003309	active site
582402003310	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
582402003311	Phage capsid family; Region: Phage_capsid; pfam05065
582402003312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402003313	non-specific DNA binding site [nucleotide binding]; other site
582402003314	salt bridge; other site
582402003315	sequence-specific DNA binding site [nucleotide binding]; other site
582402003316	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
582402003317	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
582402003318	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
582402003319	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
582402003320	putative hydrophobic ligand binding site [chemical binding]; other site
582402003321	Phage major tail protein 2; Region: Phage_tail_2; cl11463
582402003322	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
582402003323	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
582402003324	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
582402003325	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
582402003326	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
582402003327	NlpC/P60 family; Region: NLPC_P60; cl17555
582402003328	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
582402003329	Putative phage tail protein; Region: Phage-tail_3; pfam13550
582402003330	chaperone protein DnaJ; Provisional; Region: PRK14299
582402003331	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582402003332	HSP70 interaction site [polypeptide binding]; other site
582402003333	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
582402003334	substrate binding site [polypeptide binding]; other site
582402003335	dimer interface [polypeptide binding]; other site
582402003336	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
582402003337	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582402003338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402003339	active site
582402003340	phosphorylation site [posttranslational modification]
582402003341	intermolecular recognition site; other site
582402003342	dimerization interface [polypeptide binding]; other site
582402003343	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402003344	DNA binding site [nucleotide binding]
582402003345	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402003346	HAMP domain; Region: HAMP; pfam00672
582402003347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003348	ATP binding site [chemical binding]; other site
582402003349	Mg2+ binding site [ion binding]; other site
582402003350	G-X-G motif; other site
582402003351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402003352	TPR motif; other site
582402003353	TPR repeat; Region: TPR_11; pfam13414
582402003354	binding surface
582402003355	CcmE; Region: CcmE; pfam03100
582402003356	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
582402003357	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
582402003358	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402003359	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
582402003360	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582402003361	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582402003362	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582402003363	protein binding site [polypeptide binding]; other site
582402003364	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582402003365	protein binding site [polypeptide binding]; other site
582402003366	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582402003367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402003368	active site
582402003369	phosphorylation site [posttranslational modification]
582402003370	intermolecular recognition site; other site
582402003371	dimerization interface [polypeptide binding]; other site
582402003372	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402003373	DNA binding site [nucleotide binding]
582402003374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402003375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402003376	dimerization interface [polypeptide binding]; other site
582402003377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402003378	dimer interface [polypeptide binding]; other site
582402003379	phosphorylation site [posttranslational modification]
582402003380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003381	ATP binding site [chemical binding]; other site
582402003382	Mg2+ binding site [ion binding]; other site
582402003383	G-X-G motif; other site
582402003384	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
582402003385	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582402003386	metal binding triad; other site
582402003387	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582402003388	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582402003389	metal binding triad; other site
582402003390	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582402003391	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
582402003392	EF-hand domain pair; Region: EF_hand_5; pfam13499
582402003393	Ca2+ binding site [ion binding]; other site
582402003394	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
582402003395	Ca2+ binding site [ion binding]; other site
582402003396	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
582402003397	EF-hand domain pair; Region: EF_hand_5; pfam13499
582402003398	Ca2+ binding site [ion binding]; other site
582402003399	RNA polymerase sigma factor; Reviewed; Region: PRK05602
582402003400	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402003401	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402003402	DNA binding residues [nucleotide binding]
582402003403	Heavy-metal resistance; Region: Metal_resist; pfam13801
582402003404	dimer interface [polypeptide binding]; other site
582402003405	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582402003406	PAS fold; Region: PAS_7; pfam12860
582402003407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402003408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402003409	dimer interface [polypeptide binding]; other site
582402003410	phosphorylation site [posttranslational modification]
582402003411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003412	ATP binding site [chemical binding]; other site
582402003413	Mg2+ binding site [ion binding]; other site
582402003414	G-X-G motif; other site
582402003415	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402003416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402003417	active site
582402003418	phosphorylation site [posttranslational modification]
582402003419	intermolecular recognition site; other site
582402003420	dimerization interface [polypeptide binding]; other site
582402003421	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402003422	aminopeptidase N; Provisional; Region: pepN; PRK14015
582402003423	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
582402003424	Zn binding site [ion binding]; other site
582402003425	Peptidase family M48; Region: Peptidase_M48; pfam01435
582402003426	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
582402003427	putative acyl-acceptor binding pocket; other site
582402003428	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
582402003429	active site
582402003430	Predicted exporter [General function prediction only]; Region: COG4258
582402003431	Protein export membrane protein; Region: SecD_SecF; cl14618
582402003432	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
582402003433	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582402003434	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
582402003435	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
582402003436	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582402003437	dimer interface [polypeptide binding]; other site
582402003438	active site
582402003439	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
582402003440	active site 2 [active]
582402003441	active site 1 [active]
582402003442	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402003443	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
582402003444	NAD(P) binding site [chemical binding]; other site
582402003445	active site
582402003446	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
582402003447	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582402003448	dimer interface [polypeptide binding]; other site
582402003449	active site
582402003450	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
582402003451	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
582402003452	Ligand binding site; other site
582402003453	Putative Catalytic site; other site
582402003454	DXD motif; other site
582402003455	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
582402003456	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
582402003457	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582402003458	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582402003459	putative acyl-acceptor binding pocket; other site
582402003460	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582402003461	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582402003462	Predicted membrane protein [Function unknown]; Region: COG4648
582402003463	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
582402003464	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402003465	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402003466	acyl-activating enzyme (AAE) consensus motif; other site
582402003467	acyl-activating enzyme (AAE) consensus motif; other site
582402003468	active site
582402003469	AMP binding site [chemical binding]; other site
582402003470	CoA binding site [chemical binding]; other site
582402003471	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
582402003472	active site 2 [active]
582402003473	active site 1 [active]
582402003474	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
582402003475	active site residue [active]
582402003476	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
582402003477	active sites [active]
582402003478	tetramer interface [polypeptide binding]; other site
582402003479	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
582402003480	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
582402003481	active site
582402003482	dimer interface [polypeptide binding]; other site
582402003483	Predicted membrane protein [Function unknown]; Region: COG2246
582402003484	GtrA-like protein; Region: GtrA; pfam04138
582402003485	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582402003486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402003487	NAD(P) binding site [chemical binding]; other site
582402003488	active site
582402003489	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
582402003490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
582402003491	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
582402003492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003493	S-adenosylmethionine binding site [chemical binding]; other site
582402003494	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
582402003495	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582402003496	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
582402003497	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
582402003498	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402003499	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402003500	DNA binding residues [nucleotide binding]
582402003501	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
582402003502	Putative zinc-finger; Region: zf-HC2; pfam13490
582402003503	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
582402003504	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
582402003505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003506	S-adenosylmethionine binding site [chemical binding]; other site
582402003507	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582402003508	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
582402003509	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
582402003510	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582402003511	HIGH motif; other site
582402003512	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582402003513	active site
582402003514	KMSKS motif; other site
582402003515	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
582402003516	tRNA binding surface [nucleotide binding]; other site
582402003517	anticodon binding site; other site
582402003518	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
582402003519	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
582402003520	catalytic nucleophile [active]
582402003521	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
582402003522	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582402003523	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402003524	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
582402003525	Protein of unknown function (DUF983); Region: DUF983; cl02211
582402003526	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
582402003527	putative catalytic site [active]
582402003528	putative phosphate binding site [ion binding]; other site
582402003529	active site
582402003530	metal binding site A [ion binding]; metal-binding site
582402003531	DNA binding site [nucleotide binding]
582402003532	putative AP binding site [nucleotide binding]; other site
582402003533	putative metal binding site B [ion binding]; other site
582402003534	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
582402003535	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
582402003536	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582402003537	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
582402003538	active site
582402003539	metal binding site [ion binding]; metal-binding site
582402003540	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402003541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402003542	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
582402003543	substrate binding pocket [chemical binding]; other site
582402003544	dimerization interface [polypeptide binding]; other site
582402003545	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
582402003546	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582402003547	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402003548	catalytic residue [active]
582402003549	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
582402003550	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
582402003551	active site residue [active]
582402003552	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
582402003553	active site residue [active]
582402003554	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
582402003555	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
582402003556	dimer interface [polypeptide binding]; other site
582402003557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402003558	catalytic residue [active]
582402003559	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
582402003560	active site
582402003561	catalytic triad [active]
582402003562	oxyanion hole [active]
582402003563	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
582402003564	active site
582402003565	Zn binding site [ion binding]; other site
582402003566	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
582402003567	Recombination protein O N terminal; Region: RecO_N; pfam11967
582402003568	Recombination protein O C terminal; Region: RecO_C; pfam02565
582402003569	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
582402003570	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
582402003571	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
582402003572	CAP-like domain; other site
582402003573	active site
582402003574	primary dimer interface [polypeptide binding]; other site
582402003575	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
582402003576	Protein of unknown function (DUF423); Region: DUF423; pfam04241
582402003577	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582402003578	GAF domain; Region: GAF; pfam01590
582402003579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582402003580	Histidine kinase; Region: HisKA_2; pfam07568
582402003581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003582	ATP binding site [chemical binding]; other site
582402003583	Mg2+ binding site [ion binding]; other site
582402003584	G-X-G motif; other site
582402003585	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
582402003586	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
582402003587	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
582402003588	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
582402003589	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
582402003590	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
582402003591	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
582402003592	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
582402003593	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
582402003594	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
582402003595	transmembrane helices; other site
582402003596	TrkA-C domain; Region: TrkA_C; pfam02080
582402003597	TrkA-C domain; Region: TrkA_C; pfam02080
582402003598	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
582402003599	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
582402003600	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
582402003601	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
582402003602	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582402003603	ligand binding site [chemical binding]; other site
582402003604	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
582402003605	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
582402003606	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
582402003607	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
582402003608	putative active site [active]
582402003609	PrkA family serine protein kinase; Provisional; Region: PRK15455
582402003610	AAA ATPase domain; Region: AAA_16; pfam13191
582402003611	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
582402003612	hypothetical protein; Provisional; Region: PRK05325
582402003613	SpoVR family protein; Provisional; Region: PRK11767
582402003614	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
582402003615	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582402003616	GIY-YIG motif/motif A; other site
582402003617	putative active site [active]
582402003618	putative metal binding site [ion binding]; other site
582402003619	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
582402003620	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582402003621	NADP binding site [chemical binding]; other site
582402003622	dimer interface [polypeptide binding]; other site
582402003623	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
582402003624	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402003625	putative C-terminal domain interface [polypeptide binding]; other site
582402003626	putative GSH binding site (G-site) [chemical binding]; other site
582402003627	putative dimer interface [polypeptide binding]; other site
582402003628	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
582402003629	putative N-terminal domain interface [polypeptide binding]; other site
582402003630	putative dimer interface [polypeptide binding]; other site
582402003631	putative substrate binding pocket (H-site) [chemical binding]; other site
582402003632	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
582402003633	dimer interface [polypeptide binding]; other site
582402003634	allosteric magnesium binding site [ion binding]; other site
582402003635	active site
582402003636	aspartate-rich active site metal binding site; other site
582402003637	Schiff base residues; other site
582402003638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402003639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582402003640	Coenzyme A binding pocket [chemical binding]; other site
582402003641	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
582402003642	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402003643	substrate binding site [chemical binding]; other site
582402003644	oxyanion hole (OAH) forming residues; other site
582402003645	trimer interface [polypeptide binding]; other site
582402003646	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
582402003647	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402003648	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
582402003649	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
582402003650	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
582402003651	substrate-cofactor binding pocket; other site
582402003652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402003653	catalytic residue [active]
582402003654	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
582402003655	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
582402003656	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
582402003657	dimer interface [polypeptide binding]; other site
582402003658	active site
582402003659	glycine-pyridoxal phosphate binding site [chemical binding]; other site
582402003660	folate binding site [chemical binding]; other site
582402003661	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
582402003662	ATP cone domain; Region: ATP-cone; pfam03477
582402003663	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
582402003664	Lumazine binding domain; Region: Lum_binding; pfam00677
582402003665	Lumazine binding domain; Region: Lum_binding; pfam00677
582402003666	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
582402003667	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
582402003668	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
582402003669	dimerization interface [polypeptide binding]; other site
582402003670	active site
582402003671	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
582402003672	homopentamer interface [polypeptide binding]; other site
582402003673	active site
582402003674	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
582402003675	putative RNA binding site [nucleotide binding]; other site
582402003676	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
582402003677	thiamine-monophosphate kinase; Region: thiL; TIGR01379
582402003678	ATP binding site [chemical binding]; other site
582402003679	dimerization interface [polypeptide binding]; other site
582402003680	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
582402003681	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
582402003682	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
582402003683	putative phosphate acyltransferase; Provisional; Region: PRK05331
582402003684	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
582402003685	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582402003686	dimer interface [polypeptide binding]; other site
582402003687	active site
582402003688	CoA binding pocket [chemical binding]; other site
582402003689	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582402003690	IHF dimer interface [polypeptide binding]; other site
582402003691	IHF - DNA interface [nucleotide binding]; other site
582402003692	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
582402003693	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
582402003694	DNA binding residues [nucleotide binding]
582402003695	Acyltransferase family; Region: Acyl_transf_3; pfam01757
582402003696	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
582402003697	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
582402003698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582402003699	Zn2+ binding site [ion binding]; other site
582402003700	Mg2+ binding site [ion binding]; other site
582402003701	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
582402003702	Sporulation related domain; Region: SPOR; pfam05036
582402003703	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402003704	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582402003705	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
582402003706	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
582402003707	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
582402003708	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
582402003709	sec-independent translocase; Provisional; Region: PRK00708
582402003710	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
582402003711	seryl-tRNA synthetase; Provisional; Region: PRK05431
582402003712	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
582402003713	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
582402003714	dimer interface [polypeptide binding]; other site
582402003715	active site
582402003716	motif 1; other site
582402003717	motif 2; other site
582402003718	motif 3; other site
582402003719	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
582402003720	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
582402003721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003722	S-adenosylmethionine binding site [chemical binding]; other site
582402003723	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
582402003724	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582402003725	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402003726	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582402003727	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402003728	Preprotein translocase subunit; Region: YajC; pfam02699
582402003729	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
582402003730	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
582402003731	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
582402003732	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
582402003733	Protein export membrane protein; Region: SecD_SecF; pfam02355
582402003734	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
582402003735	HAMP domain; Region: HAMP; pfam00672
582402003736	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402003737	dimer interface [polypeptide binding]; other site
582402003738	putative CheW interface [polypeptide binding]; other site
582402003739	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
582402003740	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
582402003741	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
582402003742	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
582402003743	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
582402003744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402003745	motif II; other site
582402003746	Response regulator receiver domain; Region: Response_reg; pfam00072
582402003747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402003748	active site
582402003749	phosphorylation site [posttranslational modification]
582402003750	intermolecular recognition site; other site
582402003751	dimerization interface [polypeptide binding]; other site
582402003752	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
582402003753	Glucose inhibited division protein A; Region: GIDA; pfam01134
582402003754	Double zinc ribbon; Region: DZR; pfam12773
582402003755	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
582402003756	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
582402003757	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
582402003758	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
582402003759	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
582402003760	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
582402003761	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
582402003762	dimer interface [polypeptide binding]; other site
582402003763	ssDNA binding site [nucleotide binding]; other site
582402003764	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582402003765	DNA gyrase subunit A; Validated; Region: PRK05560
582402003766	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
582402003767	CAP-like domain; other site
582402003768	active site
582402003769	primary dimer interface [polypeptide binding]; other site
582402003770	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003771	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003772	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003773	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003774	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003775	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582402003776	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
582402003777	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
582402003778	active site
582402003779	(T/H)XGH motif; other site
582402003780	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
582402003781	active site
582402003782	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
582402003783	active site
582402003784	enoyl-CoA hydratase; Provisional; Region: PRK06127
582402003785	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402003786	substrate binding site [chemical binding]; other site
582402003787	oxyanion hole (OAH) forming residues; other site
582402003788	trimer interface [polypeptide binding]; other site
582402003789	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582402003790	DNA-binding site [nucleotide binding]; DNA binding site
582402003791	RNA-binding motif; other site
582402003792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402003793	ATP binding site [chemical binding]; other site
582402003794	Mg2+ binding site [ion binding]; other site
582402003795	G-X-G motif; other site
582402003796	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
582402003797	Ligand binding site; other site
582402003798	metal-binding site
582402003799	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
582402003800	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
582402003801	XdhC Rossmann domain; Region: XdhC_C; pfam13478
582402003802	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
582402003803	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582402003804	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
582402003805	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582402003806	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582402003807	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
582402003808	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582402003809	catalytic loop [active]
582402003810	iron binding site [ion binding]; other site
582402003811	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
582402003812	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
582402003813	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402003814	FeS/SAM binding site; other site
582402003815	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
582402003816	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
582402003817	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
582402003818	FMN binding site [chemical binding]; other site
582402003819	active site
582402003820	catalytic residues [active]
582402003821	substrate binding site [chemical binding]; other site
582402003822	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582402003823	catalytic motif [active]
582402003824	Catalytic residue [active]
582402003825	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
582402003826	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
582402003827	putative dimer interface [polypeptide binding]; other site
582402003828	active site pocket [active]
582402003829	putative cataytic base [active]
582402003830	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
582402003831	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
582402003832	active site
582402003833	HIGH motif; other site
582402003834	dimer interface [polypeptide binding]; other site
582402003835	KMSKS motif; other site
582402003836	S4 RNA-binding domain; Region: S4; smart00363
582402003837	RNA binding surface [nucleotide binding]; other site
582402003838	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
582402003839	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
582402003840	Predicted transcriptional regulator [Transcription]; Region: COG1959
582402003841	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402003842	dimerization interface [polypeptide binding]; other site
582402003843	putative DNA binding site [nucleotide binding]; other site
582402003844	putative Zn2+ binding site [ion binding]; other site
582402003845	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
582402003846	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
582402003847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402003848	catalytic residue [active]
582402003849	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
582402003850	putative ABC transporter; Region: ycf24; CHL00085
582402003851	FeS assembly ATPase SufC; Region: sufC; TIGR01978
582402003852	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
582402003853	Walker A/P-loop; other site
582402003854	ATP binding site [chemical binding]; other site
582402003855	Q-loop/lid; other site
582402003856	ABC transporter signature motif; other site
582402003857	Walker B; other site
582402003858	D-loop; other site
582402003859	H-loop/switch region; other site
582402003860	FeS assembly protein SufD; Region: sufD; TIGR01981
582402003861	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
582402003862	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582402003863	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
582402003864	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402003865	catalytic residue [active]
582402003866	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
582402003867	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
582402003868	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402003869	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003870	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003871	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
582402003872	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
582402003873	type II secretion system protein D; Region: type_II_gspD; TIGR02517
582402003874	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582402003875	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582402003876	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582402003877	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
582402003878	type II secretion system protein E; Region: type_II_gspE; TIGR02533
582402003879	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582402003880	Walker A motif; other site
582402003881	ATP binding site [chemical binding]; other site
582402003882	Walker B motif; other site
582402003883	type II secretion system protein F; Region: GspF; TIGR02120
582402003884	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582402003885	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582402003886	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
582402003887	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
582402003888	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
582402003889	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
582402003890	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
582402003891	type II secretion system protein I; Region: gspI; TIGR01707
582402003892	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
582402003893	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
582402003894	type II secretion system protein J; Region: gspJ; TIGR01711
582402003895	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
582402003896	PilX N-terminal; Region: PilX_N; pfam14341
582402003897	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
582402003898	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
582402003899	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
582402003900	GspL periplasmic domain; Region: GspL_C; cl14909
582402003901	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
582402003902	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
582402003903	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
582402003904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582402003905	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402003906	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003907	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402003908	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
582402003909	hypothetical protein; Provisional; Region: PRK08262
582402003910	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
582402003911	metal binding site [ion binding]; metal-binding site
582402003912	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
582402003913	active site
582402003914	DNA polymerase IV; Validated; Region: PRK02406
582402003915	DNA binding site [nucleotide binding]
582402003916	Acyltransferase family; Region: Acyl_transf_3; pfam01757
582402003917	SET domain; Region: SET; pfam00856
582402003918	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
582402003919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
582402003920	dimer interface [polypeptide binding]; other site
582402003921	active site
582402003922	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402003923	catalytic residues [active]
582402003924	substrate binding site [chemical binding]; other site
582402003925	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
582402003926	ApbE family; Region: ApbE; pfam02424
582402003927	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
582402003928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
582402003929	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
582402003930	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
582402003931	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
582402003932	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582402003933	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582402003934	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402003935	N-terminal plug; other site
582402003936	ligand-binding site [chemical binding]; other site
582402003937	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
582402003938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402003939	DNA binding residues [nucleotide binding]
582402003940	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582402003941	FecR protein; Region: FecR; pfam04773
582402003942	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402003943	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003944	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003945	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402003946	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003947	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402003948	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
582402003949	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
582402003950	putative active site [active]
582402003951	metal binding site [ion binding]; metal-binding site
582402003952	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402003953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402003954	non-specific DNA binding site [nucleotide binding]; other site
582402003955	salt bridge; other site
582402003956	sequence-specific DNA binding site [nucleotide binding]; other site
582402003957	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
582402003958	Domain of unknown function (DUF955); Region: DUF955; pfam06114
582402003959	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
582402003960	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
582402003961	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
582402003962	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
582402003963	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
582402003964	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402003965	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582402003966	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
582402003967	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582402003968	carboxyltransferase (CT) interaction site; other site
582402003969	biotinylation site [posttranslational modification]; other site
582402003970	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
582402003971	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
582402003972	active site
582402003973	substrate binding site [chemical binding]; other site
582402003974	coenzyme B12 binding site [chemical binding]; other site
582402003975	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
582402003976	B12 binding site [chemical binding]; other site
582402003977	cobalt ligand [ion binding]; other site
582402003978	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
582402003979	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402003980	DNA-binding site [nucleotide binding]; DNA binding site
582402003981	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
582402003982	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
582402003983	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582402003984	putative NAD(P) binding site [chemical binding]; other site
582402003985	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
582402003986	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402003987	classical (c) SDRs; Region: SDR_c; cd05233
582402003988	NAD(P) binding site [chemical binding]; other site
582402003989	active site
582402003990	REDY-like protein HapK; Region: HapK; pfam11639
582402003991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402003992	S-adenosylmethionine binding site [chemical binding]; other site
582402003993	FAD binding domain; Region: FAD_binding_2; pfam00890
582402003994	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
582402003995	FAD binding domain; Region: FAD_binding_4; pfam01565
582402003996	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
582402003997	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
582402003998	NAD(P) binding site [chemical binding]; other site
582402003999	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
582402004000	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
582402004001	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
582402004002	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
582402004003	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
582402004004	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
582402004005	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
582402004006	tetramer interface [polypeptide binding]; other site
582402004007	active site
582402004008	Mg2+/Mn2+ binding site [ion binding]; other site
582402004009	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
582402004010	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
582402004011	substrate binding site [chemical binding]; other site
582402004012	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582402004013	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582402004014	substrate binding site [chemical binding]; other site
582402004015	ligand binding site [chemical binding]; other site
582402004016	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
582402004017	putative active site [active]
582402004018	putative catalytic site [active]
582402004019	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
582402004020	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
582402004021	putative active site [active]
582402004022	putative catalytic site [active]
582402004023	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
582402004024	Isochorismatase family; Region: Isochorismatase; pfam00857
582402004025	catalytic triad [active]
582402004026	conserved cis-peptide bond; other site
582402004027	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
582402004028	active site
582402004029	catalytic residues [active]
582402004030	metal binding site [ion binding]; metal-binding site
582402004031	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
582402004032	CoA-transferase family III; Region: CoA_transf_3; pfam02515
582402004033	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582402004034	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582402004035	substrate binding site [chemical binding]; other site
582402004036	ligand binding site [chemical binding]; other site
582402004037	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
582402004038	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
582402004039	substrate binding site [chemical binding]; other site
582402004040	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402004041	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402004042	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
582402004043	FAD binding domain; Region: FAD_binding_4; pfam01565
582402004044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402004045	putative substrate translocation pore; other site
582402004046	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402004047	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402004048	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402004049	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
582402004050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402004051	putative substrate translocation pore; other site
582402004052	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402004053	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402004054	N-terminal plug; other site
582402004055	ligand-binding site [chemical binding]; other site
582402004056	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
582402004057	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
582402004058	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582402004059	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582402004060	ligand binding site [chemical binding]; other site
582402004061	flexible hinge region; other site
582402004062	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
582402004063	non-specific DNA interactions [nucleotide binding]; other site
582402004064	DNA binding site [nucleotide binding]
582402004065	sequence specific DNA binding site [nucleotide binding]; other site
582402004066	putative cAMP binding site [chemical binding]; other site
582402004067	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402004068	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402004069	N-terminal plug; other site
582402004070	ligand-binding site [chemical binding]; other site
582402004071	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
582402004072	cell density-dependent motility repressor; Provisional; Region: PRK10082
582402004073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402004074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582402004075	dimerization interface [polypeptide binding]; other site
582402004076	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
582402004077	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
582402004078	putative ligand binding site [chemical binding]; other site
582402004079	putative NAD binding site [chemical binding]; other site
582402004080	catalytic site [active]
582402004081	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
582402004082	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
582402004083	substrate binding site [chemical binding]; other site
582402004084	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582402004085	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582402004086	substrate binding site [chemical binding]; other site
582402004087	ligand binding site [chemical binding]; other site
582402004088	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
582402004089	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582402004090	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
582402004091	FtsX-like permease family; Region: FtsX; pfam02687
582402004092	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582402004093	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
582402004094	Walker A/P-loop; other site
582402004095	ATP binding site [chemical binding]; other site
582402004096	Q-loop/lid; other site
582402004097	ABC transporter signature motif; other site
582402004098	Walker B; other site
582402004099	D-loop; other site
582402004100	H-loop/switch region; other site
582402004101	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
582402004102	RyR domain; Region: RyR; pfam02026
582402004103	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
582402004104	RyR domain; Region: RyR; pfam02026
582402004105	salicylate hydroxylase; Provisional; Region: PRK08163
582402004106	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582402004107	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
582402004108	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
582402004109	domain interfaces; other site
582402004110	active site
582402004111	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
582402004112	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
582402004113	active site
582402004114	intersubunit interface [polypeptide binding]; other site
582402004115	catalytic residue [active]
582402004116	Glucokinase; Region: Glucokinase; pfam02685
582402004117	glucokinase, proteobacterial type; Region: glk; TIGR00749
582402004118	phosphogluconate dehydratase; Validated; Region: PRK09054
582402004119	6-phosphogluconate dehydratase; Region: edd; TIGR01196
582402004120	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
582402004121	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
582402004122	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
582402004123	TraB family; Region: TraB; pfam01963
582402004124	Zinc-finger domain; Region: zf-CHCC; pfam10276
582402004125	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
582402004126	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
582402004127	active site
582402004128	substrate binding site [chemical binding]; other site
582402004129	metal binding site [ion binding]; metal-binding site
582402004130	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
582402004131	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
582402004132	Walker A/P-loop; other site
582402004133	ATP binding site [chemical binding]; other site
582402004134	Q-loop/lid; other site
582402004135	ABC transporter signature motif; other site
582402004136	Walker B; other site
582402004137	D-loop; other site
582402004138	H-loop/switch region; other site
582402004139	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
582402004140	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582402004141	Active Sites [active]
582402004142	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
582402004143	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
582402004144	CysD dimerization site [polypeptide binding]; other site
582402004145	G1 box; other site
582402004146	putative GEF interaction site [polypeptide binding]; other site
582402004147	GTP/Mg2+ binding site [chemical binding]; other site
582402004148	Switch I region; other site
582402004149	G2 box; other site
582402004150	G3 box; other site
582402004151	Switch II region; other site
582402004152	G4 box; other site
582402004153	G5 box; other site
582402004154	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
582402004155	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
582402004156	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
582402004157	ligand-binding site [chemical binding]; other site
582402004158	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
582402004159	active site
582402004160	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402004161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402004162	putative DNA binding site [nucleotide binding]; other site
582402004163	putative Zn2+ binding site [ion binding]; other site
582402004164	AsnC family; Region: AsnC_trans_reg; pfam01037
582402004165	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582402004166	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
582402004167	inhibitor-cofactor binding pocket; inhibition site
582402004168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402004169	catalytic residue [active]
582402004170	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
582402004171	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
582402004172	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
582402004173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
582402004174	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
582402004175	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
582402004176	NAD(P) binding site [chemical binding]; other site
582402004177	catalytic residues [active]
582402004178	hypothetical protein; Provisional; Region: PRK07338
582402004179	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
582402004180	metal binding site [ion binding]; metal-binding site
582402004181	dimer interface [polypeptide binding]; other site
582402004182	succinylarginine dihydrolase; Provisional; Region: PRK13281
582402004183	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
582402004184	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
582402004185	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
582402004186	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
582402004187	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
582402004188	Fe-S cluster binding site [ion binding]; other site
582402004189	DNA binding site [nucleotide binding]
582402004190	active site
582402004191	Uncharacterized conserved protein [Function unknown]; Region: COG1432
582402004192	LabA_like proteins; Region: LabA; cd10911
582402004193	putative metal binding site [ion binding]; other site
582402004194	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
582402004195	catalytic center binding site [active]
582402004196	ATP binding site [chemical binding]; other site
582402004197	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
582402004198	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
582402004199	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582402004200	Zn2+ binding site [ion binding]; other site
582402004201	Mg2+ binding site [ion binding]; other site
582402004202	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
582402004203	synthetase active site [active]
582402004204	NTP binding site [chemical binding]; other site
582402004205	metal binding site [ion binding]; metal-binding site
582402004206	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
582402004207	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402004208	active site
582402004209	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
582402004210	active site
582402004211	hydrophilic channel; other site
582402004212	dimerization interface [polypeptide binding]; other site
582402004213	catalytic residues [active]
582402004214	active site lid [active]
582402004215	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
582402004216	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
582402004217	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
582402004218	dimerization interface [polypeptide binding]; other site
582402004219	active site
582402004220	metal binding site [ion binding]; metal-binding site
582402004221	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
582402004222	dsRNA binding site [nucleotide binding]; other site
582402004223	GTPase Era; Reviewed; Region: era; PRK00089
582402004224	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
582402004225	G1 box; other site
582402004226	GTP/Mg2+ binding site [chemical binding]; other site
582402004227	Switch I region; other site
582402004228	G2 box; other site
582402004229	Switch II region; other site
582402004230	G3 box; other site
582402004231	G4 box; other site
582402004232	G5 box; other site
582402004233	KH domain; Region: KH_2; pfam07650
582402004234	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
582402004235	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402004236	putative metal binding site; other site
582402004237	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
582402004238	Uncharacterized conserved protein [Function unknown]; Region: COG2928
582402004239	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
582402004240	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
582402004241	generic binding surface II; other site
582402004242	ssDNA binding site; other site
582402004243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402004244	ATP binding site [chemical binding]; other site
582402004245	putative Mg++ binding site [ion binding]; other site
582402004246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402004247	nucleotide binding region [chemical binding]; other site
582402004248	ATP-binding site [chemical binding]; other site
582402004249	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
582402004250	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
582402004251	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
582402004252	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402004253	ATP binding site [chemical binding]; other site
582402004254	putative Mg++ binding site [ion binding]; other site
582402004255	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402004256	nucleotide binding region [chemical binding]; other site
582402004257	ATP-binding site [chemical binding]; other site
582402004258	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
582402004259	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
582402004260	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402004261	metal binding site [ion binding]; metal-binding site
582402004262	active site
582402004263	I-site; other site
582402004264	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402004265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402004266	metal binding site [ion binding]; metal-binding site
582402004267	active site
582402004268	I-site; other site
582402004269	helicase 45; Provisional; Region: PTZ00424
582402004270	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
582402004271	ATP binding site [chemical binding]; other site
582402004272	Mg++ binding site [ion binding]; other site
582402004273	motif III; other site
582402004274	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402004275	nucleotide binding region [chemical binding]; other site
582402004276	ATP-binding site [chemical binding]; other site
582402004277	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582402004278	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582402004279	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
582402004280	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
582402004281	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
582402004282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
582402004283	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582402004284	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582402004285	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
582402004286	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
582402004287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
582402004288	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
582402004289	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
582402004290	putative di-iron ligands [ion binding]; other site
582402004291	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402004292	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
582402004293	CoenzymeA binding site [chemical binding]; other site
582402004294	subunit interaction site [polypeptide binding]; other site
582402004295	PHB binding site; other site
582402004296	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
582402004297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402004298	NAD(P) binding site [chemical binding]; other site
582402004299	active site
582402004300	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
582402004301	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
582402004302	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402004303	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402004304	N-terminal plug; other site
582402004305	ligand-binding site [chemical binding]; other site
582402004306	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402004307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402004308	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582402004309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402004310	putative substrate translocation pore; other site
582402004311	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402004312	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582402004313	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
582402004314	putative active site [active]
582402004315	putative catalytic site [active]
582402004316	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
582402004317	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402004318	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582402004319	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
582402004320	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582402004321	carboxyltransferase (CT) interaction site; other site
582402004322	biotinylation site [posttranslational modification]; other site
582402004323	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
582402004324	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402004325	substrate binding site [chemical binding]; other site
582402004326	oxyanion hole (OAH) forming residues; other site
582402004327	trimer interface [polypeptide binding]; other site
582402004328	isovaleryl-CoA dehydrogenase; Region: PLN02519
582402004329	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
582402004330	substrate binding site [chemical binding]; other site
582402004331	FAD binding site [chemical binding]; other site
582402004332	catalytic base [active]
582402004333	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402004334	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402004335	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582402004336	dimerization interface [polypeptide binding]; other site
582402004337	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582402004338	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
582402004339	pseudouridine synthase; Region: TIGR00093
582402004340	probable active site [active]
582402004341	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582402004342	GAF domain; Region: GAF; pfam01590
582402004343	PAS fold; Region: PAS_4; pfam08448
582402004344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582402004345	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
582402004346	PAS fold; Region: PAS_4; pfam08448
582402004347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402004348	dimer interface [polypeptide binding]; other site
582402004349	phosphorylation site [posttranslational modification]
582402004350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402004351	ATP binding site [chemical binding]; other site
582402004352	G-X-G motif; other site
582402004353	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402004354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402004355	active site
582402004356	phosphorylation site [posttranslational modification]
582402004357	intermolecular recognition site; other site
582402004358	dimerization interface [polypeptide binding]; other site
582402004359	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
582402004360	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
582402004361	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
582402004362	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
582402004363	RNA binding site [nucleotide binding]; other site
582402004364	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
582402004365	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
582402004366	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
582402004367	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
582402004368	TPP-binding site [chemical binding]; other site
582402004369	tetramer interface [polypeptide binding]; other site
582402004370	heterodimer interface [polypeptide binding]; other site
582402004371	phosphorylation loop region [posttranslational modification]
582402004372	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
582402004373	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
582402004374	alpha subunit interface [polypeptide binding]; other site
582402004375	TPP binding site [chemical binding]; other site
582402004376	heterodimer interface [polypeptide binding]; other site
582402004377	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582402004378	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582402004379	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
582402004380	E3 interaction surface; other site
582402004381	lipoyl attachment site [posttranslational modification]; other site
582402004382	e3 binding domain; Region: E3_binding; pfam02817
582402004383	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
582402004384	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
582402004385	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402004386	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402004387	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582402004388	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
582402004389	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582402004390	molybdopterin cofactor binding site; other site
582402004391	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
582402004392	molybdopterin cofactor binding site; other site
582402004393	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
582402004394	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
582402004395	active site
582402004396	catalytic site [active]
582402004397	substrate binding site [chemical binding]; other site
582402004398	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
582402004399	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582402004400	putative active site [active]
582402004401	putative metal binding site [ion binding]; other site
582402004402	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
582402004403	MoaE homodimer interface [polypeptide binding]; other site
582402004404	MoaD interaction [polypeptide binding]; other site
582402004405	active site residues [active]
582402004406	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
582402004407	MoaE interaction surface [polypeptide binding]; other site
582402004408	MoeB interaction surface [polypeptide binding]; other site
582402004409	thiocarboxylated glycine; other site
582402004410	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
582402004411	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402004412	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
582402004413	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
582402004414	Proline dehydrogenase; Region: Pro_dh; pfam01619
582402004415	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
582402004416	Glutamate binding site [chemical binding]; other site
582402004417	NAD binding site [chemical binding]; other site
582402004418	catalytic residues [active]
582402004419	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
582402004420	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
582402004421	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402004422	putative DNA binding site [nucleotide binding]; other site
582402004423	putative Zn2+ binding site [ion binding]; other site
582402004424	AsnC family; Region: AsnC_trans_reg; pfam01037
582402004425	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
582402004426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402004427	catalytic residue [active]
582402004428	putative hydrolase; Provisional; Region: PRK02113
582402004429	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
582402004430	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
582402004431	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
582402004432	active site
582402004433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582402004434	DNA polymerase III subunit delta'; Validated; Region: PRK07471
582402004435	DNA polymerase III subunit delta'; Validated; Region: PRK08485
582402004436	thymidylate kinase; Validated; Region: tmk; PRK00698
582402004437	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
582402004438	TMP-binding site; other site
582402004439	ATP-binding site [chemical binding]; other site
582402004440	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
582402004441	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
582402004442	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
582402004443	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
582402004444	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
582402004445	Sporulation related domain; Region: SPOR; pfam05036
582402004446	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582402004447	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582402004448	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
582402004449	DNA methylase; Region: N6_N4_Mtase; pfam01555
582402004450	DNA methylase; Region: N6_N4_Mtase; pfam01555
582402004451	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
582402004452	GIY-YIG motif/motif A; other site
582402004453	putative active site [active]
582402004454	putative metal binding site [ion binding]; other site
582402004455	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
582402004456	Helix-turn-helix domain; Region: HTH_17; pfam12728
582402004457	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
582402004458	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
582402004459	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402004460	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
582402004461	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
582402004462	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
582402004463	putative active site [active]
582402004464	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402004465	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
582402004466	Walker A/P-loop; other site
582402004467	ATP binding site [chemical binding]; other site
582402004468	Q-loop/lid; other site
582402004469	ABC transporter signature motif; other site
582402004470	Walker B; other site
582402004471	D-loop; other site
582402004472	H-loop/switch region; other site
582402004473	integrase; Provisional; Region: PRK09692
582402004474	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582402004475	active site
582402004476	Int/Topo IB signature motif; other site
582402004477	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
582402004478	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
582402004479	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
582402004480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582402004481	dimer interface [polypeptide binding]; other site
582402004482	conserved gate region; other site
582402004483	putative PBP binding loops; other site
582402004484	ABC-ATPase subunit interface; other site
582402004485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402004486	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
582402004487	Walker A/P-loop; other site
582402004488	ATP binding site [chemical binding]; other site
582402004489	Q-loop/lid; other site
582402004490	ABC transporter signature motif; other site
582402004491	Walker B; other site
582402004492	D-loop; other site
582402004493	H-loop/switch region; other site
582402004494	TOBE domain; Region: TOBE; pfam03459
582402004495	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
582402004496	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
582402004497	homodimer interface [polypeptide binding]; other site
582402004498	metal binding site [ion binding]; metal-binding site
582402004499	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
582402004500	homodimer interface [polypeptide binding]; other site
582402004501	active site
582402004502	putative chemical substrate binding site [chemical binding]; other site
582402004503	metal binding site [ion binding]; metal-binding site
582402004504	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
582402004505	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
582402004506	HflX GTPase family; Region: HflX; cd01878
582402004507	G1 box; other site
582402004508	GTP/Mg2+ binding site [chemical binding]; other site
582402004509	Switch I region; other site
582402004510	G2 box; other site
582402004511	G3 box; other site
582402004512	Switch II region; other site
582402004513	G4 box; other site
582402004514	G5 box; other site
582402004515	bacterial Hfq-like; Region: Hfq; cd01716
582402004516	hexamer interface [polypeptide binding]; other site
582402004517	Sm1 motif; other site
582402004518	RNA binding site [nucleotide binding]; other site
582402004519	Sm2 motif; other site
582402004520	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
582402004521	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
582402004522	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
582402004523	TrkA-N domain; Region: TrkA_N; pfam02254
582402004524	TrkA-C domain; Region: TrkA_C; pfam02080
582402004525	TrkA-N domain; Region: TrkA_N; pfam02254
582402004526	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582402004527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402004528	active site
582402004529	phosphorylation site [posttranslational modification]
582402004530	intermolecular recognition site; other site
582402004531	dimerization interface [polypeptide binding]; other site
582402004532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402004533	Walker A motif; other site
582402004534	ATP binding site [chemical binding]; other site
582402004535	Walker B motif; other site
582402004536	arginine finger; other site
582402004537	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582402004538	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
582402004539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402004540	dimerization interface [polypeptide binding]; other site
582402004541	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402004542	putative active site [active]
582402004543	heme pocket [chemical binding]; other site
582402004544	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402004545	dimer interface [polypeptide binding]; other site
582402004546	phosphorylation site [posttranslational modification]
582402004547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402004548	ATP binding site [chemical binding]; other site
582402004549	Mg2+ binding site [ion binding]; other site
582402004550	G-X-G motif; other site
582402004551	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
582402004552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402004553	active site
582402004554	phosphorylation site [posttranslational modification]
582402004555	intermolecular recognition site; other site
582402004556	dimerization interface [polypeptide binding]; other site
582402004557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402004558	Walker A motif; other site
582402004559	ATP binding site [chemical binding]; other site
582402004560	Walker B motif; other site
582402004561	arginine finger; other site
582402004562	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582402004563	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582402004564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402004565	putative active site [active]
582402004566	heme pocket [chemical binding]; other site
582402004567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402004568	dimer interface [polypeptide binding]; other site
582402004569	phosphorylation site [posttranslational modification]
582402004570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402004571	ATP binding site [chemical binding]; other site
582402004572	Mg2+ binding site [ion binding]; other site
582402004573	G-X-G motif; other site
582402004574	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
582402004575	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
582402004576	FMN binding site [chemical binding]; other site
582402004577	active site
582402004578	catalytic residues [active]
582402004579	substrate binding site [chemical binding]; other site
582402004580	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
582402004581	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
582402004582	substrate binding site; other site
582402004583	dimer interface; other site
582402004584	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
582402004585	homotrimer interaction site [polypeptide binding]; other site
582402004586	zinc binding site [ion binding]; other site
582402004587	CDP-binding sites; other site
582402004588	Competence-damaged protein; Region: CinA; pfam02464
582402004589	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
582402004590	putative coenzyme Q binding site [chemical binding]; other site
582402004591	lipoyl synthase; Provisional; Region: PRK05481
582402004592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402004593	FeS/SAM binding site; other site
582402004594	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
582402004595	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402004596	acyl-activating enzyme (AAE) consensus motif; other site
582402004597	AMP binding site [chemical binding]; other site
582402004598	active site
582402004599	CoA binding site [chemical binding]; other site
582402004600	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
582402004601	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
582402004602	Low-spin heme binding site [chemical binding]; other site
582402004603	Putative water exit pathway; other site
582402004604	Binuclear center (active site) [active]
582402004605	Putative proton exit pathway; other site
582402004606	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
582402004607	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
582402004608	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
582402004609	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
582402004610	Cytochrome c; Region: Cytochrom_C; pfam00034
582402004611	Cytochrome c; Region: Cytochrom_C; pfam00034
582402004612	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
582402004613	4Fe-4S binding domain; Region: Fer4_5; pfam12801
582402004614	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
582402004615	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
582402004616	FixH; Region: FixH; pfam05751
582402004617	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
582402004618	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
582402004619	metal-binding site [ion binding]
582402004620	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582402004621	Soluble P-type ATPase [General function prediction only]; Region: COG4087
582402004622	cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847
582402004623	acetyl-CoA synthetase; Provisional; Region: PRK00174
582402004624	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
582402004625	active site
582402004626	CoA binding site [chemical binding]; other site
582402004627	acyl-activating enzyme (AAE) consensus motif; other site
582402004628	AMP binding site [chemical binding]; other site
582402004629	acetate binding site [chemical binding]; other site
582402004630	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
582402004631	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582402004632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402004633	active site
582402004634	phosphorylation site [posttranslational modification]
582402004635	intermolecular recognition site; other site
582402004636	dimerization interface [polypeptide binding]; other site
582402004637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582402004638	DNA binding residues [nucleotide binding]
582402004639	dimerization interface [polypeptide binding]; other site
582402004640	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
582402004641	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
582402004642	Na binding site [ion binding]; other site
582402004643	PAS domain; Region: PAS; smart00091
582402004644	PAS fold; Region: PAS_7; pfam12860
582402004645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402004646	dimer interface [polypeptide binding]; other site
582402004647	phosphorylation site [posttranslational modification]
582402004648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402004649	ATP binding site [chemical binding]; other site
582402004650	Mg2+ binding site [ion binding]; other site
582402004651	G-X-G motif; other site
582402004652	Response regulator receiver domain; Region: Response_reg; pfam00072
582402004653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402004654	active site
582402004655	phosphorylation site [posttranslational modification]
582402004656	intermolecular recognition site; other site
582402004657	dimerization interface [polypeptide binding]; other site
582402004658	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
582402004659	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
582402004660	Na binding site [ion binding]; other site
582402004661	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
582402004662	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
582402004663	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
582402004664	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402004665	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582402004666	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
582402004667	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582402004668	E3 interaction surface; other site
582402004669	lipoyl attachment site [posttranslational modification]; other site
582402004670	e3 binding domain; Region: E3_binding; pfam02817
582402004671	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
582402004672	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
582402004673	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582402004674	E3 interaction surface; other site
582402004675	lipoyl attachment site [posttranslational modification]; other site
582402004676	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
582402004677	alpha subunit interface [polypeptide binding]; other site
582402004678	TPP binding site [chemical binding]; other site
582402004679	heterodimer interface [polypeptide binding]; other site
582402004680	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582402004681	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
582402004682	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
582402004683	tetramer interface [polypeptide binding]; other site
582402004684	TPP-binding site [chemical binding]; other site
582402004685	heterodimer interface [polypeptide binding]; other site
582402004686	phosphorylation loop region [posttranslational modification]
582402004687	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
582402004688	Septum formation initiator; Region: DivIC; cl17659
582402004689	enolase; Provisional; Region: eno; PRK00077
582402004690	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
582402004691	dimer interface [polypeptide binding]; other site
582402004692	metal binding site [ion binding]; metal-binding site
582402004693	substrate binding pocket [chemical binding]; other site
582402004694	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
582402004695	CTP synthetase; Validated; Region: pyrG; PRK05380
582402004696	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
582402004697	Catalytic site [active]
582402004698	active site
582402004699	UTP binding site [chemical binding]; other site
582402004700	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
582402004701	active site
582402004702	putative oxyanion hole; other site
582402004703	catalytic triad [active]
582402004704	protein translocase, SecG subunit; Region: secG; TIGR00810
582402004705	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
582402004706	triosephosphate isomerase; Provisional; Region: PRK14565
582402004707	substrate binding site [chemical binding]; other site
582402004708	dimer interface [polypeptide binding]; other site
582402004709	catalytic triad [active]
582402004710	SurA N-terminal domain; Region: SurA_N_3; cl07813
582402004711	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
582402004712	anthranilate synthase component I; Provisional; Region: PRK13573
582402004713	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582402004714	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
582402004715	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
582402004716	Glutamine amidotransferase class-I; Region: GATase; pfam00117
582402004717	glutamine binding [chemical binding]; other site
582402004718	catalytic triad [active]
582402004719	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
582402004720	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
582402004721	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
582402004722	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
582402004723	active site
582402004724	ribulose/triose binding site [chemical binding]; other site
582402004725	phosphate binding site [ion binding]; other site
582402004726	substrate (anthranilate) binding pocket [chemical binding]; other site
582402004727	product (indole) binding pocket [chemical binding]; other site
582402004728	LexA repressor; Validated; Region: PRK00215
582402004729	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
582402004730	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
582402004731	Catalytic site [active]
582402004732	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
582402004733	Competence protein; Region: Competence; pfam03772
582402004734	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
582402004735	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582402004736	active site
582402004737	HIGH motif; other site
582402004738	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582402004739	active site
582402004740	KMSKS motif; other site
582402004741	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
582402004742	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
582402004743	dimer interface [polypeptide binding]; other site
582402004744	active site
582402004745	citrylCoA binding site [chemical binding]; other site
582402004746	NADH binding [chemical binding]; other site
582402004747	cationic pore residues; other site
582402004748	oxalacetate/citrate binding site [chemical binding]; other site
582402004749	coenzyme A binding site [chemical binding]; other site
582402004750	catalytic triad [active]
582402004751	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
582402004752	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
582402004753	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
582402004754	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
582402004755	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
582402004756	active site
582402004757	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
582402004758	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
582402004759	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
582402004760	trimer interface [polypeptide binding]; other site
582402004761	active site
582402004762	UDP-GlcNAc binding site [chemical binding]; other site
582402004763	lipid binding site [chemical binding]; lipid-binding site
582402004764	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
582402004765	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
582402004766	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582402004767	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582402004768	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582402004769	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582402004770	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582402004771	Surface antigen; Region: Bac_surface_Ag; pfam01103
582402004772	Surface antigen; Region: Bac_surface_Ag; pfam01103
582402004773	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
582402004774	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
582402004775	active site
582402004776	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
582402004777	protein binding site [polypeptide binding]; other site
582402004778	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
582402004779	putative substrate binding region [chemical binding]; other site
582402004780	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
582402004781	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
582402004782	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
582402004783	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
582402004784	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
582402004785	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
582402004786	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
582402004787	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
582402004788	catalytic residue [active]
582402004789	putative FPP diphosphate  binding site; other site
582402004790	putative FPP binding hydrophobic cleft; other site
582402004791	dimer interface [polypeptide binding]; other site
582402004792	putative IPP diphosphate binding site; other site
582402004793	ribosome recycling factor; Reviewed; Region: frr; PRK00083
582402004794	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
582402004795	hinge region; other site
582402004796	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
582402004797	putative nucleotide binding site [chemical binding]; other site
582402004798	uridine monophosphate binding site [chemical binding]; other site
582402004799	homohexameric interface [polypeptide binding]; other site
582402004800	elongation factor Ts; Provisional; Region: tsf; PRK09377
582402004801	UBA/TS-N domain; Region: UBA; pfam00627
582402004802	Elongation factor TS; Region: EF_TS; pfam00889
582402004803	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
582402004804	rRNA interaction site [nucleotide binding]; other site
582402004805	S8 interaction site; other site
582402004806	putative laminin-1 binding site; other site
582402004807	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
582402004808	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
582402004809	putative active site [active]
582402004810	putative PHP Thumb interface [polypeptide binding]; other site
582402004811	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
582402004812	generic binding surface I; other site
582402004813	generic binding surface II; other site
582402004814	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582402004815	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582402004816	Walker A/P-loop; other site
582402004817	ATP binding site [chemical binding]; other site
582402004818	Q-loop/lid; other site
582402004819	ABC transporter signature motif; other site
582402004820	Walker B; other site
582402004821	D-loop; other site
582402004822	H-loop/switch region; other site
582402004823	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
582402004824	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582402004825	FtsX-like permease family; Region: FtsX; pfam02687
582402004826	prolyl-tRNA synthetase; Provisional; Region: PRK12325
582402004827	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
582402004828	dimer interface [polypeptide binding]; other site
582402004829	motif 1; other site
582402004830	active site
582402004831	motif 2; other site
582402004832	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402004833	active site
582402004834	motif 3; other site
582402004835	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
582402004836	anticodon binding site; other site
582402004837	Protein of unknown function (DUF1467); Region: DUF1467; cl11569
582402004838	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
582402004839	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402004840	dimer interface [polypeptide binding]; other site
582402004841	substrate binding site [chemical binding]; other site
582402004842	metal binding site [ion binding]; metal-binding site
582402004843	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
582402004844	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
582402004845	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
582402004846	pantothenate kinase; Reviewed; Region: PRK13318
582402004847	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
582402004848	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
582402004849	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
582402004850	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402004851	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
582402004852	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402004853	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
582402004854	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
582402004855	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582402004856	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
582402004857	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
582402004858	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
582402004859	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
582402004860	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
582402004861	4Fe-4S binding domain; Region: Fer4; pfam00037
582402004862	4Fe-4S binding domain; Region: Fer4; pfam00037
582402004863	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
582402004864	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
582402004865	NADH dehydrogenase subunit G; Validated; Region: PRK09130
582402004866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582402004867	catalytic loop [active]
582402004868	iron binding site [ion binding]; other site
582402004869	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
582402004870	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582402004871	molybdopterin cofactor binding site; other site
582402004872	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
582402004873	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
582402004874	SLBB domain; Region: SLBB; pfam10531
582402004875	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
582402004876	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
582402004877	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
582402004878	putative dimer interface [polypeptide binding]; other site
582402004879	[2Fe-2S] cluster binding site [ion binding]; other site
582402004880	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582402004881	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
582402004882	NADH dehydrogenase subunit D; Validated; Region: PRK06075
582402004883	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
582402004884	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
582402004885	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
582402004886	NADH dehydrogenase subunit B; Validated; Region: PRK06411
582402004887	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
582402004888	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
582402004889	SmpB-tmRNA interface; other site
582402004890	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
582402004891	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
582402004892	dimer interface [polypeptide binding]; other site
582402004893	active site
582402004894	catalytic residue [active]
582402004895	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
582402004896	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
582402004897	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582402004898	catalytic residue [active]
582402004899	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
582402004900	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
582402004901	heterodimer interface [polypeptide binding]; other site
582402004902	substrate interaction site [chemical binding]; other site
582402004903	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
582402004904	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
582402004905	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
582402004906	active site
582402004907	substrate binding site [chemical binding]; other site
582402004908	coenzyme B12 binding site [chemical binding]; other site
582402004909	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
582402004910	B12 binding site [chemical binding]; other site
582402004911	cobalt ligand [ion binding]; other site
582402004912	membrane ATPase/protein kinase; Provisional; Region: PRK09435
582402004913	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
582402004914	Walker A; other site
582402004915	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582402004916	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582402004917	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582402004918	ligand binding site [chemical binding]; other site
582402004919	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
582402004920	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
582402004921	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
582402004922	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
582402004923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402004924	S-adenosylmethionine binding site [chemical binding]; other site
582402004925	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
582402004926	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
582402004927	Nucleoside recognition; Region: Gate; pfam07670
582402004928	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
582402004929	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582402004930	Ligand Binding Site [chemical binding]; other site
582402004931	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582402004932	Ligand Binding Site [chemical binding]; other site
582402004933	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
582402004934	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
582402004935	Sulfate transporter family; Region: Sulfate_transp; pfam00916
582402004936	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
582402004937	Protein of unknown function; Region: DUF3971; pfam13116
582402004938	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
582402004939	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
582402004940	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
582402004941	catalytic triad [active]
582402004942	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582402004943	Peptidase family M23; Region: Peptidase_M23; pfam01551
582402004944	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
582402004945	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582402004946	Domain of unknown function (DUF329); Region: DUF329; cl01144
582402004947	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582402004948	RNA binding site [nucleotide binding]; other site
582402004949	Maf-like protein; Region: Maf; pfam02545
582402004950	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582402004951	active site
582402004952	dimer interface [polypeptide binding]; other site
582402004953	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
582402004954	rRNA binding site [nucleotide binding]; other site
582402004955	predicted 30S ribosome binding site; other site
582402004956	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
582402004957	Low molecular weight phosphatase family; Region: LMWPc; cd00115
582402004958	active site
582402004959	hypothetical protein; Provisional; Region: PRK02853
582402004960	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
582402004961	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
582402004962	NAD binding site [chemical binding]; other site
582402004963	dimerization interface [polypeptide binding]; other site
582402004964	product binding site; other site
582402004965	substrate binding site [chemical binding]; other site
582402004966	zinc binding site [ion binding]; other site
582402004967	catalytic residues [active]
582402004968	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
582402004969	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
582402004970	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
582402004971	hinge; other site
582402004972	active site
582402004973	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
582402004974	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582402004975	catalytic loop [active]
582402004976	iron binding site [ion binding]; other site
582402004977	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
582402004978	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
582402004979	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
582402004980	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582402004981	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582402004982	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402004983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402004984	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402004985	dimerization interface [polypeptide binding]; other site
582402004986	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
582402004987	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
582402004988	active site
582402004989	catalytic site [active]
582402004990	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582402004991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402004992	dimerization interface [polypeptide binding]; other site
582402004993	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402004994	dimer interface [polypeptide binding]; other site
582402004995	putative CheW interface [polypeptide binding]; other site
582402004996	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
582402004997	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
582402004998	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
582402004999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402005000	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582402005001	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582402005002	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402005003	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582402005004	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402005005	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
582402005006	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
582402005007	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582402005008	active site
582402005009	metal binding site [ion binding]; metal-binding site
582402005010	TIR domain; Region: TIR_2; pfam13676
582402005011	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402005012	Uncharacterized conserved protein [Function unknown]; Region: COG1262
582402005013	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
582402005014	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582402005015	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
582402005016	SLBB domain; Region: SLBB; pfam10531
582402005017	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
582402005018	Chain length determinant protein; Region: Wzz; pfam02706
582402005019	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
582402005020	Chain length determinant protein; Region: Wzz; cl15801
582402005021	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
582402005022	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582402005023	O-Antigen ligase; Region: Wzy_C; pfam04932
582402005024	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
582402005025	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
582402005026	NADP binding site [chemical binding]; other site
582402005027	active site
582402005028	putative substrate binding site [chemical binding]; other site
582402005029	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
582402005030	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
582402005031	NADP-binding site; other site
582402005032	homotetramer interface [polypeptide binding]; other site
582402005033	substrate binding site [chemical binding]; other site
582402005034	homodimer interface [polypeptide binding]; other site
582402005035	active site
582402005036	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
582402005037	Found in ATP-dependent protease La (LON); Region: LON; smart00464
582402005038	Found in ATP-dependent protease La (LON); Region: LON; smart00464
582402005039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402005040	Walker A motif; other site
582402005041	ATP binding site [chemical binding]; other site
582402005042	Walker B motif; other site
582402005043	arginine finger; other site
582402005044	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
582402005045	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
582402005046	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
582402005047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402005048	Walker A motif; other site
582402005049	ATP binding site [chemical binding]; other site
582402005050	Walker B motif; other site
582402005051	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
582402005052	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
582402005053	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
582402005054	oligomer interface [polypeptide binding]; other site
582402005055	active site residues [active]
582402005056	trigger factor; Provisional; Region: tig; PRK01490
582402005057	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582402005058	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
582402005059	Uncharacterized conserved protein [Function unknown]; Region: COG0062
582402005060	putative carbohydrate kinase; Provisional; Region: PRK10565
582402005061	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
582402005062	putative substrate binding site [chemical binding]; other site
582402005063	putative ATP binding site [chemical binding]; other site
582402005064	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
582402005065	Nitrogen regulatory protein P-II; Region: P-II; smart00938
582402005066	glutamine synthetase; Provisional; Region: glnA; PRK09469
582402005067	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
582402005068	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582402005069	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
582402005070	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582402005071	catalytic residue [active]
582402005072	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
582402005073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402005074	ATP binding site [chemical binding]; other site
582402005075	Mg2+ binding site [ion binding]; other site
582402005076	G-X-G motif; other site
582402005077	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
582402005078	anchoring element; other site
582402005079	dimer interface [polypeptide binding]; other site
582402005080	ATP binding site [chemical binding]; other site
582402005081	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
582402005082	active site
582402005083	metal binding site [ion binding]; metal-binding site
582402005084	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
582402005085	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582402005086	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
582402005087	putative NAD(P) binding site [chemical binding]; other site
582402005088	active site
582402005089	putative substrate binding site [chemical binding]; other site
582402005090	GMP synthase; Reviewed; Region: guaA; PRK00074
582402005091	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
582402005092	AMP/PPi binding site [chemical binding]; other site
582402005093	candidate oxyanion hole; other site
582402005094	catalytic triad [active]
582402005095	potential glutamine specificity residues [chemical binding]; other site
582402005096	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
582402005097	ATP Binding subdomain [chemical binding]; other site
582402005098	Ligand Binding sites [chemical binding]; other site
582402005099	Dimerization subdomain; other site
582402005100	serine racemase; Region: PLN02970
582402005101	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
582402005102	tetramer interface [polypeptide binding]; other site
582402005103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402005104	catalytic residue [active]
582402005105	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
582402005106	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
582402005107	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
582402005108	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582402005109	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
582402005110	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
582402005111	active site
582402005112	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
582402005113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
582402005114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402005115	S-adenosylmethionine binding site [chemical binding]; other site
582402005116	exopolyphosphatase; Region: exo_poly_only; TIGR03706
582402005117	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
582402005118	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582402005119	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
582402005120	ligand binding site [chemical binding]; other site
582402005121	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
582402005122	trimer interface [polypeptide binding]; other site
582402005123	dimer interface [polypeptide binding]; other site
582402005124	putative active site [active]
582402005125	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
582402005126	MPT binding site; other site
582402005127	trimer interface [polypeptide binding]; other site
582402005128	Autoinducer synthetase; Region: Autoind_synth; cl17404
582402005129	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
582402005130	Patatin [General function prediction only]; Region: COG3621
582402005131	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
582402005132	active site
582402005133	nucleophile elbow; other site
582402005134	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
582402005135	active site
582402005136	NTP binding site [chemical binding]; other site
582402005137	metal binding triad [ion binding]; metal-binding site
582402005138	excinuclease ABC subunit B; Provisional; Region: PRK05298
582402005139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402005140	ATP binding site [chemical binding]; other site
582402005141	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402005142	nucleotide binding region [chemical binding]; other site
582402005143	ATP-binding site [chemical binding]; other site
582402005144	Ultra-violet resistance protein B; Region: UvrB; pfam12344
582402005145	UvrB/uvrC motif; Region: UVR; pfam02151
582402005146	PAS fold; Region: PAS_4; pfam08448
582402005147	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402005148	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402005149	metal binding site [ion binding]; metal-binding site
582402005150	active site
582402005151	I-site; other site
582402005152	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402005153	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582402005154	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402005155	active site
582402005156	Protein of unknown function, DUF599; Region: DUF599; cl01575
582402005157	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
582402005158	Zn binding site [ion binding]; other site
582402005159	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582402005160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402005161	S-adenosylmethionine binding site [chemical binding]; other site
582402005162	NAD synthetase; Provisional; Region: PRK13981
582402005163	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
582402005164	multimer interface [polypeptide binding]; other site
582402005165	active site
582402005166	catalytic triad [active]
582402005167	protein interface 1 [polypeptide binding]; other site
582402005168	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
582402005169	homodimer interface [polypeptide binding]; other site
582402005170	NAD binding pocket [chemical binding]; other site
582402005171	ATP binding pocket [chemical binding]; other site
582402005172	Mg binding site [ion binding]; other site
582402005173	active-site loop [active]
582402005174	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
582402005175	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
582402005176	inhibitor-cofactor binding pocket; inhibition site
582402005177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402005178	catalytic residue [active]
582402005179	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
582402005180	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
582402005181	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
582402005182	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582402005183	IHF dimer interface [polypeptide binding]; other site
582402005184	IHF - DNA interface [nucleotide binding]; other site
582402005185	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
582402005186	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
582402005187	cation binding site [ion binding]; other site
582402005188	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
582402005189	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582402005190	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402005191	P-loop; other site
582402005192	Magnesium ion binding site [ion binding]; other site
582402005193	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402005194	Magnesium ion binding site [ion binding]; other site
582402005195	glutathione reductase; Validated; Region: PRK06116
582402005196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402005197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402005198	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582402005199	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
582402005200	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582402005201	active site
582402005202	dimer interface [polypeptide binding]; other site
582402005203	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
582402005204	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
582402005205	Substrate binding site; other site
582402005206	Mg++ binding site; other site
582402005207	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
582402005208	active site
582402005209	substrate binding site [chemical binding]; other site
582402005210	CoA binding site [chemical binding]; other site
582402005211	phosphoglycolate phosphatase; Provisional; Region: PRK13222
582402005212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402005213	motif II; other site
582402005214	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
582402005215	active site
582402005216	catalytic residues [active]
582402005217	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402005218	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402005219	DNA binding site [nucleotide binding]
582402005220	domain linker motif; other site
582402005221	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402005222	putative dimerization interface [polypeptide binding]; other site
582402005223	putative ligand binding site [chemical binding]; other site
582402005224	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
582402005225	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
582402005226	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
582402005227	putative active site [active]
582402005228	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
582402005229	putative active site [active]
582402005230	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
582402005231	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582402005232	DNA-binding site [nucleotide binding]; DNA binding site
582402005233	RNA-binding motif; other site
582402005234	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582402005235	DNA-binding site [nucleotide binding]; DNA binding site
582402005236	RNA-binding motif; other site
582402005237	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
582402005238	DHH family; Region: DHH; pfam01368
582402005239	DHHA1 domain; Region: DHHA1; pfam02272
582402005240	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
582402005241	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
582402005242	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
582402005243	putative active site [active]
582402005244	homoserine dehydrogenase; Provisional; Region: PRK06349
582402005245	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
582402005246	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
582402005247	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
582402005248	aminotransferase; Validated; Region: PRK09148
582402005249	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402005250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402005251	homodimer interface [polypeptide binding]; other site
582402005252	catalytic residue [active]
582402005253	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
582402005254	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
582402005255	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
582402005256	active site
582402005257	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
582402005258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402005259	active site
582402005260	motif I; other site
582402005261	motif II; other site
582402005262	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
582402005263	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
582402005264	sucrose phosphorylase; Provisional; Region: PRK13840
582402005265	active site
582402005266	homodimer interface [polypeptide binding]; other site
582402005267	catalytic site [active]
582402005268	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
582402005269	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
582402005270	active site
582402005271	catalytic site [active]
582402005272	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
582402005273	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
582402005274	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
582402005275	active site
582402005276	catalytic site [active]
582402005277	glycogen synthase; Provisional; Region: glgA; PRK00654
582402005278	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
582402005279	ADP-binding pocket [chemical binding]; other site
582402005280	homodimer interface [polypeptide binding]; other site
582402005281	glycogen branching enzyme; Provisional; Region: PRK05402
582402005282	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
582402005283	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
582402005284	active site
582402005285	catalytic site [active]
582402005286	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
582402005287	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
582402005288	homodimer interface [polypeptide binding]; other site
582402005289	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
582402005290	active site pocket [active]
582402005291	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
582402005292	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
582402005293	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
582402005294	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
582402005295	23S rRNA interface [nucleotide binding]; other site
582402005296	L3 interface [polypeptide binding]; other site
582402005297	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
582402005298	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
582402005299	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
582402005300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402005301	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
582402005302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402005303	Walker A/P-loop; other site
582402005304	ATP binding site [chemical binding]; other site
582402005305	Q-loop/lid; other site
582402005306	ABC transporter signature motif; other site
582402005307	Walker B; other site
582402005308	D-loop; other site
582402005309	H-loop/switch region; other site
582402005310	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
582402005311	Excalibur calcium-binding domain; Region: Excalibur; smart00894
582402005312	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
582402005313	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
582402005314	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
582402005315	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582402005316	HIGH motif; other site
582402005317	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582402005318	active site
582402005319	KMSKS motif; other site
582402005320	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
582402005321	Staphylococcal nuclease homologues; Region: SNc; smart00318
582402005322	Catalytic site; other site
582402005323	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
582402005324	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
582402005325	acyl-activating enzyme (AAE) consensus motif; other site
582402005326	putative AMP binding site [chemical binding]; other site
582402005327	putative active site [active]
582402005328	putative CoA binding site [chemical binding]; other site
582402005329	peptide chain release factor 2; Validated; Region: prfB; PRK00578
582402005330	This domain is found in peptide chain release factors; Region: PCRF; smart00937
582402005331	RF-1 domain; Region: RF-1; pfam00472
582402005332	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
582402005333	Transglycosylase; Region: Transgly; pfam00912
582402005334	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582402005335	AMIN domain; Region: AMIN; pfam11741
582402005336	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
582402005337	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
582402005338	active site
582402005339	metal binding site [ion binding]; metal-binding site
582402005340	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
582402005341	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582402005342	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
582402005343	Peptidase family M48; Region: Peptidase_M48; cl12018
582402005344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402005345	binding surface
582402005346	TPR motif; other site
582402005347	TPR repeat; Region: TPR_11; pfam13414
582402005348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402005349	TPR motif; other site
582402005350	binding surface
582402005351	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
582402005352	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402005353	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
582402005354	ThiS interaction site; other site
582402005355	putative active site [active]
582402005356	tetramer interface [polypeptide binding]; other site
582402005357	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
582402005358	thiS-thiF/thiG interaction site; other site
582402005359	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
582402005360	Dehydroquinase class II; Region: DHquinase_II; pfam01220
582402005361	trimer interface [polypeptide binding]; other site
582402005362	active site
582402005363	dimer interface [polypeptide binding]; other site
582402005364	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
582402005365	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582402005366	carboxyltransferase (CT) interaction site; other site
582402005367	biotinylation site [posttranslational modification]; other site
582402005368	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
582402005369	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402005370	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582402005371	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
582402005372	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
582402005373	mce related protein; Region: MCE; pfam02470
582402005374	NADH dehydrogenase; Validated; Region: PRK08183
582402005375	TSCPD domain; Region: TSCPD; pfam12637
582402005376	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
582402005377	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582402005378	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582402005379	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582402005380	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
582402005381	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
582402005382	dimer interface [polypeptide binding]; other site
582402005383	anticodon binding site; other site
582402005384	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
582402005385	homodimer interface [polypeptide binding]; other site
582402005386	motif 1; other site
582402005387	active site
582402005388	motif 2; other site
582402005389	GAD domain; Region: GAD; pfam02938
582402005390	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582402005391	active site
582402005392	motif 3; other site
582402005393	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
582402005394	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
582402005395	catalytic site [active]
582402005396	putative active site [active]
582402005397	putative substrate binding site [chemical binding]; other site
582402005398	HRDC domain; Region: HRDC; pfam00570
582402005399	exopolyphosphatase; Region: exo_poly_only; TIGR03706
582402005400	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
582402005401	polyphosphate kinase; Provisional; Region: PRK05443
582402005402	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
582402005403	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
582402005404	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
582402005405	putative domain interface [polypeptide binding]; other site
582402005406	putative active site [active]
582402005407	catalytic site [active]
582402005408	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
582402005409	putative domain interface [polypeptide binding]; other site
582402005410	putative active site [active]
582402005411	catalytic site [active]
582402005412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582402005413	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
582402005414	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
582402005415	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
582402005416	dimerization interface [polypeptide binding]; other site
582402005417	putative ATP binding site [chemical binding]; other site
582402005418	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
582402005419	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
582402005420	active site
582402005421	substrate binding site [chemical binding]; other site
582402005422	cosubstrate binding site; other site
582402005423	catalytic site [active]
582402005424	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402005425	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402005426	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582402005427	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
582402005428	active site residue [active]
582402005429	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
582402005430	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582402005431	PGAP1-like protein; Region: PGAP1; pfam07819
582402005432	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
582402005433	Protein of unknown function, DUF; Region: DUF413; cl10479
582402005434	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
582402005435	active site
582402005436	multimer interface [polypeptide binding]; other site
582402005437	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
582402005438	multifunctional aminopeptidase A; Provisional; Region: PRK00913
582402005439	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
582402005440	interface (dimer of trimers) [polypeptide binding]; other site
582402005441	Substrate-binding/catalytic site; other site
582402005442	Zn-binding sites [ion binding]; other site
582402005443	Predicted permeases [General function prediction only]; Region: COG0795
582402005444	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582402005445	Predicted permeases [General function prediction only]; Region: COG0795
582402005446	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582402005447	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
582402005448	OstA-like protein; Region: OstA; cl00844
582402005449	Organic solvent tolerance protein; Region: OstA_C; pfam04453
582402005450	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
582402005451	SurA N-terminal domain; Region: SurA_N; pfam09312
582402005452	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
582402005453	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
582402005454	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
582402005455	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
582402005456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402005457	S-adenosylmethionine binding site [chemical binding]; other site
582402005458	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
582402005459	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
582402005460	catalytic site [active]
582402005461	G-X2-G-X-G-K; other site
582402005462	hypothetical protein; Provisional; Region: PRK11820
582402005463	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
582402005464	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
582402005465	YceG-like family; Region: YceG; pfam02618
582402005466	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
582402005467	dimerization interface [polypeptide binding]; other site
582402005468	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
582402005469	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582402005470	dimer interface [polypeptide binding]; other site
582402005471	active site
582402005472	acyl carrier protein; Provisional; Region: acpP; PRK00982
582402005473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402005474	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
582402005475	NAD(P) binding site [chemical binding]; other site
582402005476	active site
582402005477	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
582402005478	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
582402005479	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
582402005480	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
582402005481	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
582402005482	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
582402005483	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
582402005484	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
582402005485	replicative DNA helicase; Provisional; Region: PRK09165
582402005486	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
582402005487	Walker A motif; other site
582402005488	ATP binding site [chemical binding]; other site
582402005489	Walker B motif; other site
582402005490	DNA binding loops [nucleotide binding]
582402005491	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
582402005492	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
582402005493	active site
582402005494	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582402005495	dimer interface [polypeptide binding]; other site
582402005496	substrate binding site [chemical binding]; other site
582402005497	catalytic residues [active]
582402005498	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
582402005499	Permease; Region: Permease; pfam02405
582402005500	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
582402005501	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
582402005502	Walker A/P-loop; other site
582402005503	ATP binding site [chemical binding]; other site
582402005504	Q-loop/lid; other site
582402005505	ABC transporter signature motif; other site
582402005506	Walker B; other site
582402005507	D-loop; other site
582402005508	H-loop/switch region; other site
582402005509	DNA repair protein RadA; Provisional; Region: PRK11823
582402005510	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
582402005511	Walker A motif; other site
582402005512	ATP binding site [chemical binding]; other site
582402005513	Walker B motif; other site
582402005514	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
582402005515	Colicin V production protein; Region: Colicin_V; pfam02674
582402005516	amidophosphoribosyltransferase; Provisional; Region: PRK09123
582402005517	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
582402005518	active site
582402005519	tetramer interface [polypeptide binding]; other site
582402005520	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582402005521	active site
582402005522	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
582402005523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402005524	NAD(P) binding site [chemical binding]; other site
582402005525	active site
582402005526	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
582402005527	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
582402005528	GTP-binding protein Der; Reviewed; Region: PRK00093
582402005529	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
582402005530	G1 box; other site
582402005531	GTP/Mg2+ binding site [chemical binding]; other site
582402005532	Switch I region; other site
582402005533	G2 box; other site
582402005534	Switch II region; other site
582402005535	G3 box; other site
582402005536	G4 box; other site
582402005537	G5 box; other site
582402005538	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
582402005539	G1 box; other site
582402005540	GTP/Mg2+ binding site [chemical binding]; other site
582402005541	Switch I region; other site
582402005542	G2 box; other site
582402005543	G3 box; other site
582402005544	Switch II region; other site
582402005545	G4 box; other site
582402005546	G5 box; other site
582402005547	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
582402005548	Trp docking motif [polypeptide binding]; other site
582402005549	active site
582402005550	PQQ-like domain; Region: PQQ_2; pfam13360
582402005551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
582402005552	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
582402005553	oligomerization interface [polypeptide binding]; other site
582402005554	active site
582402005555	metal binding site [ion binding]; metal-binding site
582402005556	NnrU protein; Region: NnrU; pfam07298
582402005557	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402005558	MarR family; Region: MarR; pfam01047
582402005559	Uncharacterized conserved protein [Function unknown]; Region: COG2135
582402005560	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
582402005561	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
582402005562	Bacterial sugar transferase; Region: Bac_transf; pfam02397
582402005563	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
582402005564	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402005565	active site
582402005566	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582402005567	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
582402005568	putative active site [active]
582402005569	putative metal binding site [ion binding]; other site
582402005570	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402005571	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402005572	active site
582402005573	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
582402005574	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
582402005575	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
582402005576	Chain length determinant protein; Region: Wzz; cl15801
582402005577	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582402005578	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
582402005579	SLBB domain; Region: SLBB; pfam10531
582402005580	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582402005581	Sel1-like repeats; Region: SEL1; smart00671
582402005582	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
582402005583	O-Antigen ligase; Region: Wzy_C; pfam04932
582402005584	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
582402005585	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
582402005586	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
582402005587	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
582402005588	hypothetical protein; Provisional; Region: PRK09256
582402005589	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
582402005590	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
582402005591	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
582402005592	GatB domain; Region: GatB_Yqey; smart00845
582402005593	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582402005594	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582402005595	active site
582402005596	catalytic tetrad [active]
582402005597	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
582402005598	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
582402005599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402005600	Coenzyme A binding pocket [chemical binding]; other site
582402005601	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
582402005602	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
582402005603	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402005604	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
582402005605	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
582402005606	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
582402005607	DNA protecting protein DprA; Region: dprA; TIGR00732
582402005608	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
582402005609	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
582402005610	active site
582402005611	interdomain interaction site; other site
582402005612	putative metal-binding site [ion binding]; other site
582402005613	nucleotide binding site [chemical binding]; other site
582402005614	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
582402005615	domain I; other site
582402005616	DNA binding groove [nucleotide binding]
582402005617	phosphate binding site [ion binding]; other site
582402005618	domain II; other site
582402005619	domain III; other site
582402005620	nucleotide binding site [chemical binding]; other site
582402005621	catalytic site [active]
582402005622	domain IV; other site
582402005623	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
582402005624	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582402005625	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582402005626	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582402005627	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
582402005628	ribonuclease R; Region: RNase_R; TIGR02063
582402005629	RNB domain; Region: RNB; pfam00773
582402005630	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
582402005631	RNA binding site [nucleotide binding]; other site
582402005632	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
582402005633	nudix motif; other site
582402005634	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
582402005635	response regulator PleD; Reviewed; Region: pleD; PRK09581
582402005636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402005637	active site
582402005638	phosphorylation site [posttranslational modification]
582402005639	intermolecular recognition site; other site
582402005640	dimerization interface [polypeptide binding]; other site
582402005641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402005642	active site
582402005643	phosphorylation site [posttranslational modification]
582402005644	intermolecular recognition site; other site
582402005645	dimerization interface [polypeptide binding]; other site
582402005646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402005647	metal binding site [ion binding]; metal-binding site
582402005648	active site
582402005649	I-site; other site
582402005650	Response regulator receiver domain; Region: Response_reg; pfam00072
582402005651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402005652	active site
582402005653	phosphorylation site [posttranslational modification]
582402005654	intermolecular recognition site; other site
582402005655	dimerization interface [polypeptide binding]; other site
582402005656	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
582402005657	homotrimer interaction site [polypeptide binding]; other site
582402005658	putative active site [active]
582402005659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
582402005660	Protein of unknown function, DUF482; Region: DUF482; pfam04339
582402005661	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
582402005662	HIT family signature motif; other site
582402005663	catalytic residue [active]
582402005664	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402005665	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
582402005666	putative GSH binding site (G-site) [chemical binding]; other site
582402005667	active site cysteine [active]
582402005668	putative C-terminal domain interface [polypeptide binding]; other site
582402005669	putative dimer interface [polypeptide binding]; other site
582402005670	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
582402005671	putative N-terminal domain interface [polypeptide binding]; other site
582402005672	putative dimer interface [polypeptide binding]; other site
582402005673	putative substrate binding pocket (H-site) [chemical binding]; other site
582402005674	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
582402005675	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
582402005676	FRG domain; Region: FRG; cl07460
582402005677	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
582402005678	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
582402005679	active site residue [active]
582402005680	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
582402005681	Clp amino terminal domain; Region: Clp_N; pfam02861
582402005682	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402005683	Walker A motif; other site
582402005684	ATP binding site [chemical binding]; other site
582402005685	Walker B motif; other site
582402005686	arginine finger; other site
582402005687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402005688	Walker A motif; other site
582402005689	ATP binding site [chemical binding]; other site
582402005690	Walker B motif; other site
582402005691	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582402005692	Uncharacterized conserved protein [Function unknown]; Region: COG2127
582402005693	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
582402005694	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
582402005695	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
582402005696	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402005697	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
582402005698	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
582402005699	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
582402005700	DNA binding residues [nucleotide binding]
582402005701	putative dimer interface [polypeptide binding]; other site
582402005702	BNR repeat-like domain; Region: BNR_2; pfam13088
582402005703	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
582402005704	Asp-box motif; other site
582402005705	ATPase MipZ; Region: MipZ; pfam09140
582402005706	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402005707	P-loop; other site
582402005708	Magnesium ion binding site [ion binding]; other site
582402005709	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402005710	Magnesium ion binding site [ion binding]; other site
582402005711	Pantoate-beta-alanine ligase; Region: PanC; cd00560
582402005712	pantoate--beta-alanine ligase; Region: panC; TIGR00018
582402005713	active site
582402005714	ATP-binding site [chemical binding]; other site
582402005715	pantoate-binding site; other site
582402005716	HXXH motif; other site
582402005717	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
582402005718	enoyl-CoA hydratase; Provisional; Region: PRK05995
582402005719	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402005720	substrate binding site [chemical binding]; other site
582402005721	oxyanion hole (OAH) forming residues; other site
582402005722	trimer interface [polypeptide binding]; other site
582402005723	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582402005724	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582402005725	ligand binding site [chemical binding]; other site
582402005726	flexible hinge region; other site
582402005727	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582402005728	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
582402005729	active site
582402005730	nucleophile elbow; other site
582402005731	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
582402005732	catalytic residues [active]
582402005733	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
582402005734	MgtE intracellular N domain; Region: MgtE_N; smart00924
582402005735	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
582402005736	Divalent cation transporter; Region: MgtE; cl00786
582402005737	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
582402005738	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
582402005739	transmembrane helices; other site
582402005740	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
582402005741	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
582402005742	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582402005743	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
582402005744	MgtE intracellular N domain; Region: MgtE_N; pfam03448
582402005745	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
582402005746	Divalent cation transporter; Region: MgtE; pfam01769
582402005747	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
582402005748	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582402005749	Coenzyme A binding pocket [chemical binding]; other site
582402005750	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
582402005751	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
582402005752	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582402005753	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
582402005754	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
582402005755	Cl binding site [ion binding]; other site
582402005756	oligomer interface [polypeptide binding]; other site
582402005757	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
582402005758	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402005759	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
582402005760	nucleophilic elbow; other site
582402005761	catalytic triad; other site
582402005762	Entericidin EcnA/B family; Region: Entericidin; cl02322
582402005763	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
582402005764	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
582402005765	two-component response regulator; Provisional; Region: PRK09191
582402005766	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
582402005767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402005768	active site
582402005769	phosphorylation site [posttranslational modification]
582402005770	intermolecular recognition site; other site
582402005771	dimerization interface [polypeptide binding]; other site
582402005772	RNA polymerase sigma factor; Provisional; Region: PRK12547
582402005773	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402005774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402005775	DNA binding residues [nucleotide binding]
582402005776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582402005777	Histidine kinase; Region: HisKA_2; pfam07568
582402005778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402005779	ATP binding site [chemical binding]; other site
582402005780	Mg2+ binding site [ion binding]; other site
582402005781	G-X-G motif; other site
582402005782	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
582402005783	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
582402005784	dimerization interface [polypeptide binding]; other site
582402005785	DPS ferroxidase diiron center [ion binding]; other site
582402005786	ion pore; other site
582402005787	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582402005788	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
582402005789	putative active site [active]
582402005790	putative metal binding site [ion binding]; other site
582402005791	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
582402005792	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
582402005793	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
582402005794	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
582402005795	hypothetical protein; Validated; Region: PRK06033
582402005796	lipoate-protein ligase B; Provisional; Region: PRK14341
582402005797	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
582402005798	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582402005799	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582402005800	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
582402005801	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582402005802	carboxyltransferase (CT) interaction site; other site
582402005803	biotinylation site [posttranslational modification]; other site
582402005804	Ion channel; Region: Ion_trans_2; pfam07885
582402005805	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
582402005806	GIY-YIG motif/motif A; other site
582402005807	active site
582402005808	catalytic site [active]
582402005809	metal binding site [ion binding]; metal-binding site
582402005810	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
582402005811	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
582402005812	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
582402005813	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
582402005814	ATP12 chaperone protein; Region: ATP12; cl02228
582402005815	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582402005816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402005817	motif II; other site
582402005818	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582402005819	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402005820	RNA binding surface [nucleotide binding]; other site
582402005821	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582402005822	active site
582402005823	camphor resistance protein CrcB; Provisional; Region: PRK14195
582402005824	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582402005825	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582402005826	active site
582402005827	recombination factor protein RarA; Reviewed; Region: PRK13342
582402005828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402005829	Walker A motif; other site
582402005830	ATP binding site [chemical binding]; other site
582402005831	Walker B motif; other site
582402005832	arginine finger; other site
582402005833	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
582402005834	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582402005835	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582402005836	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582402005837	protein binding site [polypeptide binding]; other site
582402005838	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582402005839	protein binding site [polypeptide binding]; other site
582402005840	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
582402005841	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
582402005842	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
582402005843	alphaNTD - beta interaction site [polypeptide binding]; other site
582402005844	alphaNTD homodimer interface [polypeptide binding]; other site
582402005845	alphaNTD - beta' interaction site [polypeptide binding]; other site
582402005846	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
582402005847	30S ribosomal protein S11; Validated; Region: PRK05309
582402005848	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
582402005849	30S ribosomal protein S13; Region: bact_S13; TIGR03631
582402005850	adenylate kinase; Provisional; Region: PRK14532
582402005851	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
582402005852	AMP-binding site [chemical binding]; other site
582402005853	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
582402005854	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
582402005855	SecY translocase; Region: SecY; pfam00344
582402005856	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
582402005857	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
582402005858	23S rRNA binding site [nucleotide binding]; other site
582402005859	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
582402005860	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
582402005861	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
582402005862	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
582402005863	23S rRNA interface [nucleotide binding]; other site
582402005864	L21e interface [polypeptide binding]; other site
582402005865	5S rRNA interface [nucleotide binding]; other site
582402005866	L27 interface [polypeptide binding]; other site
582402005867	L5 interface [polypeptide binding]; other site
582402005868	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
582402005869	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582402005870	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582402005871	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
582402005872	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
582402005873	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
582402005874	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
582402005875	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
582402005876	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
582402005877	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
582402005878	RNA binding site [nucleotide binding]; other site
582402005879	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
582402005880	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
582402005881	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
582402005882	putative translocon interaction site; other site
582402005883	23S rRNA interface [nucleotide binding]; other site
582402005884	signal recognition particle (SRP54) interaction site; other site
582402005885	L23 interface [polypeptide binding]; other site
582402005886	trigger factor interaction site; other site
582402005887	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
582402005888	23S rRNA interface [nucleotide binding]; other site
582402005889	5S rRNA interface [nucleotide binding]; other site
582402005890	putative antibiotic binding site [chemical binding]; other site
582402005891	L25 interface [polypeptide binding]; other site
582402005892	L27 interface [polypeptide binding]; other site
582402005893	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
582402005894	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
582402005895	G-X-X-G motif; other site
582402005896	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
582402005897	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
582402005898	putative translocon binding site; other site
582402005899	protein-rRNA interface [nucleotide binding]; other site
582402005900	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
582402005901	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
582402005902	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
582402005903	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
582402005904	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
582402005905	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
582402005906	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
582402005907	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
582402005908	elongation factor Tu; Reviewed; Region: PRK00049
582402005909	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
582402005910	G1 box; other site
582402005911	GEF interaction site [polypeptide binding]; other site
582402005912	GTP/Mg2+ binding site [chemical binding]; other site
582402005913	Switch I region; other site
582402005914	G2 box; other site
582402005915	G3 box; other site
582402005916	Switch II region; other site
582402005917	G4 box; other site
582402005918	G5 box; other site
582402005919	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
582402005920	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
582402005921	Antibiotic Binding Site [chemical binding]; other site
582402005922	elongation factor G; Reviewed; Region: PRK00007
582402005923	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
582402005924	G1 box; other site
582402005925	putative GEF interaction site [polypeptide binding]; other site
582402005926	GTP/Mg2+ binding site [chemical binding]; other site
582402005927	Switch I region; other site
582402005928	G2 box; other site
582402005929	G3 box; other site
582402005930	Switch II region; other site
582402005931	G4 box; other site
582402005932	G5 box; other site
582402005933	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
582402005934	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
582402005935	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
582402005936	30S ribosomal protein S7; Validated; Region: PRK05302
582402005937	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
582402005938	S17 interaction site [polypeptide binding]; other site
582402005939	S8 interaction site; other site
582402005940	16S rRNA interaction site [nucleotide binding]; other site
582402005941	streptomycin interaction site [chemical binding]; other site
582402005942	23S rRNA interaction site [nucleotide binding]; other site
582402005943	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
582402005944	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
582402005945	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
582402005946	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
582402005947	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
582402005948	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
582402005949	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
582402005950	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
582402005951	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
582402005952	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
582402005953	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
582402005954	DNA binding site [nucleotide binding]
582402005955	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
582402005956	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
582402005957	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
582402005958	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
582402005959	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582402005960	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
582402005961	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582402005962	RPB3 interaction site [polypeptide binding]; other site
582402005963	RPB1 interaction site [polypeptide binding]; other site
582402005964	RPB11 interaction site [polypeptide binding]; other site
582402005965	RPB10 interaction site [polypeptide binding]; other site
582402005966	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
582402005967	L11 interface [polypeptide binding]; other site
582402005968	putative EF-Tu interaction site [polypeptide binding]; other site
582402005969	putative EF-G interaction site [polypeptide binding]; other site
582402005970	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
582402005971	23S rRNA interface [nucleotide binding]; other site
582402005972	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
582402005973	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
582402005974	mRNA/rRNA interface [nucleotide binding]; other site
582402005975	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
582402005976	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
582402005977	23S rRNA interface [nucleotide binding]; other site
582402005978	L7/L12 interface [polypeptide binding]; other site
582402005979	putative thiostrepton binding site; other site
582402005980	L25 interface [polypeptide binding]; other site
582402005981	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
582402005982	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
582402005983	putative homodimer interface [polypeptide binding]; other site
582402005984	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
582402005985	heterodimer interface [polypeptide binding]; other site
582402005986	homodimer interface [polypeptide binding]; other site
582402005987	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
582402005988	Uncharacterized conserved protein [Function unknown]; Region: COG2308
582402005989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
582402005990	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
582402005991	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582402005992	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582402005993	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
582402005994	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
582402005995	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
582402005996	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
582402005997	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
582402005998	FMN binding site [chemical binding]; other site
582402005999	substrate binding site [chemical binding]; other site
582402006000	putative catalytic residue [active]
582402006001	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582402006002	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
582402006003	SLBB domain; Region: SLBB; pfam10531
582402006004	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402006005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006006	active site
582402006007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006008	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402006009	NAD(P) binding site [chemical binding]; other site
582402006010	active site
582402006011	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
582402006012	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
582402006013	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
582402006014	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006015	active site
582402006016	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
582402006017	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
582402006018	active site
582402006019	HIGH motif; other site
582402006020	KMSKS motif; other site
582402006021	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
582402006022	tRNA binding surface [nucleotide binding]; other site
582402006023	anticodon binding site; other site
582402006024	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
582402006025	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
582402006026	Chain length determinant protein; Region: Wzz; pfam02706
582402006027	Chain length determinant protein; Region: Wzz; cl15801
582402006028	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
582402006029	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402006030	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006031	active site
582402006032	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
582402006033	O-Antigen ligase; Region: Wzy_C; pfam04932
582402006034	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
582402006035	active site
582402006036	active site
582402006037	catalytic residues [active]
582402006038	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
582402006039	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402006040	Ligand binding site; other site
582402006041	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402006042	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
582402006043	P-loop; other site
582402006044	Magnesium ion binding site [ion binding]; other site
582402006045	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402006046	Magnesium ion binding site [ion binding]; other site
582402006047	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582402006048	metal binding site 2 [ion binding]; metal-binding site
582402006049	putative DNA binding helix; other site
582402006050	metal binding site 1 [ion binding]; metal-binding site
582402006051	dimer interface [polypeptide binding]; other site
582402006052	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
582402006053	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
582402006054	active site
582402006055	dimer interface [polypeptide binding]; other site
582402006056	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
582402006057	dimer interface [polypeptide binding]; other site
582402006058	active site
582402006059	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582402006060	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
582402006061	ATP-NAD kinase; Region: NAD_kinase; pfam01513
582402006062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
582402006063	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
582402006064	Response regulator receiver domain; Region: Response_reg; pfam00072
582402006065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006066	active site
582402006067	phosphorylation site [posttranslational modification]
582402006068	intermolecular recognition site; other site
582402006069	dimerization interface [polypeptide binding]; other site
582402006070	hydroxyglutarate oxidase; Provisional; Region: PRK11728
582402006071	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
582402006072	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
582402006073	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
582402006074	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
582402006075	NAD binding site [chemical binding]; other site
582402006076	Phe binding site; other site
582402006077	hypothetical protein; Provisional; Region: PRK08317
582402006078	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
582402006079	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582402006080	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
582402006081	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
582402006082	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
582402006083	PA/protease or protease-like domain interface [polypeptide binding]; other site
582402006084	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
582402006085	metal binding site [ion binding]; metal-binding site
582402006086	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582402006087	DNA-binding site [nucleotide binding]; DNA binding site
582402006088	RNA-binding motif; other site
582402006089	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
582402006090	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
582402006091	G1 box; other site
582402006092	GTP/Mg2+ binding site [chemical binding]; other site
582402006093	Switch I region; other site
582402006094	G2 box; other site
582402006095	G3 box; other site
582402006096	Switch II region; other site
582402006097	G4 box; other site
582402006098	G5 box; other site
582402006099	Nucleoside recognition; Region: Gate; pfam07670
582402006100	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
582402006101	Nucleoside recognition; Region: Gate; pfam07670
582402006102	FeoA domain; Region: FeoA; pfam04023
582402006103	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
582402006104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006105	NAD(P) binding site [chemical binding]; other site
582402006106	active site
582402006107	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
582402006108	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
582402006109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
582402006110	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
582402006111	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
582402006112	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
582402006113	substrate binding site; other site
582402006114	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
582402006115	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
582402006116	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402006117	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006118	active site
582402006119	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
582402006120	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
582402006121	putative ADP-binding pocket [chemical binding]; other site
582402006122	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402006123	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006124	active site
582402006125	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402006126	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582402006127	active site
582402006128	colanic acid exporter; Provisional; Region: PRK10459
582402006129	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
582402006130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582402006131	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582402006132	active site
582402006133	catalytic tetrad [active]
582402006134	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
582402006135	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
582402006136	putative dimer interface [polypeptide binding]; other site
582402006137	active site pocket [active]
582402006138	putative cataytic base [active]
582402006139	cobalamin synthase; Reviewed; Region: cobS; PRK00235
582402006140	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402006141	catalytic core [active]
582402006142	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
582402006143	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
582402006144	homodimer interface [polypeptide binding]; other site
582402006145	Walker A motif; other site
582402006146	ATP binding site [chemical binding]; other site
582402006147	hydroxycobalamin binding site [chemical binding]; other site
582402006148	Walker B motif; other site
582402006149	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582402006150	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402006151	N-terminal plug; other site
582402006152	ligand-binding site [chemical binding]; other site
582402006153	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
582402006154	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
582402006155	intersubunit interface [polypeptide binding]; other site
582402006156	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
582402006157	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
582402006158	ABC-ATPase subunit  interface; other site
582402006159	dimer interface [polypeptide binding]; other site
582402006160	putative PBP binding regions; other site
582402006161	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
582402006162	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
582402006163	Walker A/P-loop; other site
582402006164	ATP binding site [chemical binding]; other site
582402006165	Q-loop/lid; other site
582402006166	ABC transporter signature motif; other site
582402006167	Walker B; other site
582402006168	D-loop; other site
582402006169	H-loop/switch region; other site
582402006170	cobyric acid synthase; Provisional; Region: PRK00784
582402006171	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
582402006172	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
582402006173	catalytic triad [active]
582402006174	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
582402006175	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
582402006176	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402006177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402006178	homodimer interface [polypeptide binding]; other site
582402006179	catalytic residue [active]
582402006180	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
582402006181	homotrimer interface [polypeptide binding]; other site
582402006182	Walker A motif; other site
582402006183	GTP binding site [chemical binding]; other site
582402006184	Walker B motif; other site
582402006185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006186	active site
582402006187	phosphorylation site [posttranslational modification]
582402006188	dimerization interface [polypeptide binding]; other site
582402006189	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
582402006190	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
582402006191	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
582402006192	anti sigma factor interaction site; other site
582402006193	regulatory phosphorylation site [posttranslational modification]; other site
582402006194	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402006195	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402006196	dimer interface [polypeptide binding]; other site
582402006197	putative CheW interface [polypeptide binding]; other site
582402006198	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
582402006199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006200	active site
582402006201	phosphorylation site [posttranslational modification]
582402006202	intermolecular recognition site; other site
582402006203	dimerization interface [polypeptide binding]; other site
582402006204	CheB methylesterase; Region: CheB_methylest; pfam01339
582402006205	CheD chemotactic sensory transduction; Region: CheD; cl00810
582402006206	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
582402006207	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582402006208	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
582402006209	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402006210	PAS domain; Region: PAS_9; pfam13426
582402006211	putative active site [active]
582402006212	heme pocket [chemical binding]; other site
582402006213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402006214	PAS domain; Region: PAS_9; pfam13426
582402006215	putative active site [active]
582402006216	heme pocket [chemical binding]; other site
582402006217	PAS domain; Region: PAS_9; pfam13426
582402006218	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402006219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402006220	dimer interface [polypeptide binding]; other site
582402006221	putative CheW interface [polypeptide binding]; other site
582402006222	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
582402006223	putative CheA interaction surface; other site
582402006224	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
582402006225	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582402006226	putative binding surface; other site
582402006227	active site
582402006228	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582402006229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402006230	ATP binding site [chemical binding]; other site
582402006231	Mg2+ binding site [ion binding]; other site
582402006232	G-X-G motif; other site
582402006233	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582402006234	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402006235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006236	active site
582402006237	phosphorylation site [posttranslational modification]
582402006238	intermolecular recognition site; other site
582402006239	dimerization interface [polypeptide binding]; other site
582402006240	STAS domain; Region: STAS_2; pfam13466
582402006241	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582402006242	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
582402006243	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
582402006244	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582402006245	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402006246	N-terminal plug; other site
582402006247	ligand-binding site [chemical binding]; other site
582402006248	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
582402006249	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402006250	N-terminal plug; other site
582402006251	ligand-binding site [chemical binding]; other site
582402006252	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
582402006253	ApbE family; Region: ApbE; pfam02424
582402006254	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
582402006255	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
582402006256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
582402006257	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
582402006258	Uncharacterized conserved protein [Function unknown]; Region: COG2968
582402006259	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
582402006260	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
582402006261	tetramerization interface [polypeptide binding]; other site
582402006262	active site
582402006263	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
582402006264	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
582402006265	PA/protease or protease-like domain interface [polypeptide binding]; other site
582402006266	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
582402006267	Peptidase family M28; Region: Peptidase_M28; pfam04389
582402006268	metal binding site [ion binding]; metal-binding site
582402006269	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402006270	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582402006271	active site
582402006272	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402006273	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582402006274	active site
582402006275	metal binding site [ion binding]; metal-binding site
582402006276	Predicted transcriptional regulator [Transcription]; Region: COG2345
582402006277	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
582402006278	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
582402006279	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
582402006280	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
582402006281	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402006282	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402006283	putative DNA binding site [nucleotide binding]; other site
582402006284	putative Zn2+ binding site [ion binding]; other site
582402006285	AsnC family; Region: AsnC_trans_reg; pfam01037
582402006286	putative acyltransferase; Provisional; Region: PRK05790
582402006287	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
582402006288	dimer interface [polypeptide binding]; other site
582402006289	active site
582402006290	Uncharacterized conserved protein [Function unknown]; Region: COG1284
582402006291	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
582402006292	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
582402006293	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
582402006294	Ligand Binding Site [chemical binding]; other site
582402006295	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
582402006296	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
582402006297	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006298	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
582402006299	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582402006300	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582402006301	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
582402006302	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
582402006303	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
582402006304	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582402006305	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
582402006306	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
582402006307	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582402006308	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
582402006309	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
582402006310	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
582402006311	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
582402006312	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
582402006313	FliG C-terminal domain; Region: FliG_C; pfam01706
582402006314	flagellar assembly protein H; Validated; Region: fliH; PRK06032
582402006315	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
582402006316	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582402006317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402006318	Walker A motif; other site
582402006319	ATP binding site [chemical binding]; other site
582402006320	Walker B motif; other site
582402006321	arginine finger; other site
582402006322	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582402006323	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
582402006324	FHIPEP family; Region: FHIPEP; pfam00771
582402006325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582402006326	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
582402006327	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
582402006328	active site
582402006329	Walker A motif; other site
582402006330	ATP binding site [chemical binding]; other site
582402006331	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582402006332	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582402006333	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582402006334	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
582402006335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402006336	metal binding site [ion binding]; metal-binding site
582402006337	active site
582402006338	I-site; other site
582402006339	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402006340	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
582402006341	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
582402006342	Walker A motif/ATP binding site; other site
582402006343	Walker B motif; other site
582402006344	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582402006345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006346	active site
582402006347	phosphorylation site [posttranslational modification]
582402006348	intermolecular recognition site; other site
582402006349	dimerization interface [polypeptide binding]; other site
582402006350	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582402006351	DNA binding site [nucleotide binding]
582402006352	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402006353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402006354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402006355	dimerization interface [polypeptide binding]; other site
582402006356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402006357	TPR motif; other site
582402006358	binding surface
582402006359	primosome assembly protein PriA; Validated; Region: PRK05580
582402006360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582402006361	ATP binding site [chemical binding]; other site
582402006362	putative Mg++ binding site [ion binding]; other site
582402006363	helicase superfamily c-terminal domain; Region: HELICc; smart00490
582402006364	nucleotide binding region [chemical binding]; other site
582402006365	ATP-binding site [chemical binding]; other site
582402006366	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
582402006367	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582402006368	active site
582402006369	DNA binding site [nucleotide binding]
582402006370	Int/Topo IB signature motif; other site
582402006371	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
582402006372	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582402006373	ATP binding site [chemical binding]; other site
582402006374	Mg++ binding site [ion binding]; other site
582402006375	motif III; other site
582402006376	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582402006377	nucleotide binding region [chemical binding]; other site
582402006378	ATP-binding site [chemical binding]; other site
582402006379	Sulfatase; Region: Sulfatase; cl17466
582402006380	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
582402006381	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402006382	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582402006383	active site
582402006384	metal binding site [ion binding]; metal-binding site
582402006385	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
582402006386	EamA-like transporter family; Region: EamA; pfam00892
582402006387	EamA-like transporter family; Region: EamA; pfam00892
582402006388	HopJ type III effector protein; Region: HopJ; pfam08888
582402006389	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402006390	catalytic core [active]
582402006391	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582402006392	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
582402006393	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
582402006394	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
582402006395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402006396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582402006397	LytTr DNA-binding domain; Region: LytTR; smart00850
582402006398	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
582402006399	Protein of unknown function, DUF606; Region: DUF606; pfam04657
582402006400	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582402006401	E3 interaction surface; other site
582402006402	lipoyl attachment site [posttranslational modification]; other site
582402006403	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
582402006404	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582402006405	E3 interaction surface; other site
582402006406	lipoyl attachment site [posttranslational modification]; other site
582402006407	e3 binding domain; Region: E3_binding; pfam02817
582402006408	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
582402006409	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
582402006410	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
582402006411	TPP-binding site [chemical binding]; other site
582402006412	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
582402006413	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
582402006414	CoA binding domain; Region: CoA_binding; smart00881
582402006415	CoA-ligase; Region: Ligase_CoA; pfam00549
582402006416	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
582402006417	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
582402006418	CoA-ligase; Region: Ligase_CoA; pfam00549
582402006419	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
582402006420	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
582402006421	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
582402006422	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582402006423	putative catalytic residues [active]
582402006424	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
582402006425	malate dehydrogenase; Reviewed; Region: PRK06223
582402006426	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
582402006427	dimer interface [polypeptide binding]; other site
582402006428	NAD(P) binding site [chemical binding]; other site
582402006429	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582402006430	substrate binding site [chemical binding]; other site
582402006431	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
582402006432	Predicted ATPase [General function prediction only]; Region: COG1485
582402006433	inner membrane protein; Provisional; Region: PRK11715
582402006434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
582402006435	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
582402006436	putative hydrophobic ligand binding site [chemical binding]; other site
582402006437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402006438	dimerization interface [polypeptide binding]; other site
582402006439	putative DNA binding site [nucleotide binding]; other site
582402006440	putative Zn2+ binding site [ion binding]; other site
582402006441	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
582402006442	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402006443	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402006444	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
582402006445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006446	NAD(P) binding site [chemical binding]; other site
582402006447	active site
582402006448	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
582402006449	Domain of unknown function (DU1801); Region: DUF1801; cl17490
582402006450	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
582402006451	ThiC-associated domain; Region: ThiC-associated; pfam13667
582402006452	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
582402006453	SlyX; Region: SlyX; pfam04102
582402006454	Cupin-like domain; Region: Cupin_8; pfam13621
582402006455	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582402006456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402006457	Coenzyme A binding pocket [chemical binding]; other site
582402006458	Predicted amidohydrolase [General function prediction only]; Region: COG0388
582402006459	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
582402006460	putative active site [active]
582402006461	catalytic triad [active]
582402006462	putative dimer interface [polypeptide binding]; other site
582402006463	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
582402006464	GSH binding site [chemical binding]; other site
582402006465	catalytic residues [active]
582402006466	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
582402006467	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582402006468	Lysine efflux permease [General function prediction only]; Region: COG1279
582402006469	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
582402006470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402006471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402006472	dimerization interface [polypeptide binding]; other site
582402006473	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
582402006474	homotrimer interaction site [polypeptide binding]; other site
582402006475	putative active site [active]
582402006476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
582402006477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402006478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006479	NAD(P) binding site [chemical binding]; other site
582402006480	active site
582402006481	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
582402006482	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
582402006483	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
582402006484	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
582402006485	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
582402006486	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
582402006487	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
582402006488	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
582402006489	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
582402006490	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582402006491	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582402006492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402006493	S-adenosylmethionine binding site [chemical binding]; other site
582402006494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402006495	putative substrate translocation pore; other site
582402006496	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
582402006497	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
582402006498	Predicted membrane protein [Function unknown]; Region: COG1971
582402006499	Domain of unknown function DUF; Region: DUF204; pfam02659
582402006500	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
582402006501	tartrate dehydrogenase; Region: TTC; TIGR02089
582402006502	Uncharacterized conserved protein [Function unknown]; Region: COG1359
582402006503	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
582402006504	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
582402006505	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
582402006506	substrate binding site [chemical binding]; other site
582402006507	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
582402006508	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582402006509	active site
582402006510	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582402006511	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
582402006512	putative acyl-acceptor binding pocket; other site
582402006513	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402006514	putative DNA binding site [nucleotide binding]; other site
582402006515	dimerization interface [polypeptide binding]; other site
582402006516	putative Zn2+ binding site [ion binding]; other site
582402006517	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402006518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006519	active site
582402006520	phosphorylation site [posttranslational modification]
582402006521	intermolecular recognition site; other site
582402006522	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
582402006523	Transglycosylase; Region: Transgly; pfam00912
582402006524	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
582402006525	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
582402006526	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
582402006527	MG2 domain; Region: A2M_N; pfam01835
582402006528	Alpha-2-macroglobulin family; Region: A2M; pfam00207
582402006529	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
582402006530	surface patch; other site
582402006531	thioester region; other site
582402006532	specificity defining residues; other site
582402006533	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
582402006534	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
582402006535	catalytic nucleophile [active]
582402006536	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
582402006537	Uncharacterized conserved protein [Function unknown]; Region: COG3339
582402006538	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006539	flagellin; Reviewed; Region: PRK12687
582402006540	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006541	FlaG protein; Region: FlaG; cl00591
582402006542	flagellin; Reviewed; Region: PRK12687
582402006543	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006544	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006545	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
582402006546	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582402006547	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402006548	catalytic residue [active]
582402006549	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
582402006550	putative glycosyl transferase; Provisional; Region: PRK10073
582402006551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582402006552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402006553	Radical SAM superfamily; Region: Radical_SAM; pfam04055
582402006554	FeS/SAM binding site; other site
582402006555	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
582402006556	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
582402006557	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
582402006558	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
582402006559	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402006560	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582402006561	AMP binding site [chemical binding]; other site
582402006562	active site
582402006563	acyl-activating enzyme (AAE) consensus motif; other site
582402006564	CoA binding site [chemical binding]; other site
582402006565	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
582402006566	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
582402006567	putative trimer interface [polypeptide binding]; other site
582402006568	putative CoA binding site [chemical binding]; other site
582402006569	flagellin; Reviewed; Region: PRK12687
582402006570	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006571	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006572	flagellin; Reviewed; Region: PRK12687
582402006573	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006574	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006575	flagellin; Reviewed; Region: PRK12687
582402006576	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006577	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006578	flagellin; Reviewed; Region: PRK12687
582402006579	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582402006580	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582402006581	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
582402006582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402006583	motif II; other site
582402006584	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
582402006585	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
582402006586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402006587	binding surface
582402006588	Tetratricopeptide repeat; Region: TPR_16; pfam13432
582402006589	TPR motif; other site
582402006590	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402006591	binding surface
582402006592	TPR motif; other site
582402006593	TPR repeat; Region: TPR_11; pfam13414
582402006594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402006595	binding surface
582402006596	TPR motif; other site
582402006597	TPR repeat; Region: TPR_11; pfam13414
582402006598	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
582402006599	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582402006600	catalytic loop [active]
582402006601	iron binding site [ion binding]; other site
582402006602	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
582402006603	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
582402006604	Phosphotransferase enzyme family; Region: APH; pfam01636
582402006605	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
582402006606	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
582402006607	Substrate binding site; other site
582402006608	metal-binding site
582402006609	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
582402006610	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
582402006611	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
582402006612	Part of AAA domain; Region: AAA_19; pfam13245
582402006613	Family description; Region: UvrD_C_2; pfam13538
582402006614	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
582402006615	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582402006616	catalytic residues [active]
582402006617	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
582402006618	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582402006619	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
582402006620	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
582402006621	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
582402006622	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
582402006623	substrate binding site [chemical binding]; other site
582402006624	active site
582402006625	catalytic residues [active]
582402006626	heterodimer interface [polypeptide binding]; other site
582402006627	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
582402006628	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
582402006629	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
582402006630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402006631	catalytic residue [active]
582402006632	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
582402006633	active site
582402006634	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
582402006635	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
582402006636	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582402006637	IHF - DNA interface [nucleotide binding]; other site
582402006638	IHF dimer interface [polypeptide binding]; other site
582402006639	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
582402006640	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
582402006641	RNA binding site [nucleotide binding]; other site
582402006642	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
582402006643	RNA binding site [nucleotide binding]; other site
582402006644	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
582402006645	RNA binding site [nucleotide binding]; other site
582402006646	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
582402006647	RNA binding site [nucleotide binding]; other site
582402006648	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582402006649	RNA binding site [nucleotide binding]; other site
582402006650	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582402006651	RNA binding site [nucleotide binding]; other site
582402006652	cytidylate kinase; Provisional; Region: cmk; PRK00023
582402006653	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
582402006654	CMP-binding site; other site
582402006655	The sites determining sugar specificity; other site
582402006656	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
582402006657	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
582402006658	hinge; other site
582402006659	active site
582402006660	TIGR02300 family protein; Region: FYDLN_acid
582402006661	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
582402006662	Nitrogen regulatory protein P-II; Region: P-II; smart00938
582402006663	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582402006664	Methyltransferase domain; Region: Methyltransf_11; pfam08241
582402006665	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
582402006666	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
582402006667	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
582402006668	NAD(P) binding site [chemical binding]; other site
582402006669	homotetramer interface [polypeptide binding]; other site
582402006670	homodimer interface [polypeptide binding]; other site
582402006671	active site
582402006672	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
582402006673	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
582402006674	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
582402006675	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
582402006676	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
582402006677	Ligand binding site; other site
582402006678	Putative Catalytic site; other site
582402006679	DXD motif; other site
582402006680	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582402006681	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
582402006682	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
582402006683	Probable Catalytic site; other site
582402006684	metal-binding site
582402006685	O-Antigen ligase; Region: Wzy_C; pfam04932
582402006686	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
582402006687	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
582402006688	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
582402006689	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
582402006690	active site
582402006691	dimer interface [polypeptide binding]; other site
582402006692	motif 1; other site
582402006693	motif 2; other site
582402006694	motif 3; other site
582402006695	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
582402006696	anticodon binding site; other site
582402006697	hypothetical protein; Validated; Region: PRK00041
582402006698	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402006699	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402006700	dimer interface [polypeptide binding]; other site
582402006701	phosphorylation site [posttranslational modification]
582402006702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402006703	ATP binding site [chemical binding]; other site
582402006704	Mg2+ binding site [ion binding]; other site
582402006705	G-X-G motif; other site
582402006706	Response regulator receiver domain; Region: Response_reg; pfam00072
582402006707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402006708	active site
582402006709	phosphorylation site [posttranslational modification]
582402006710	intermolecular recognition site; other site
582402006711	dimerization interface [polypeptide binding]; other site
582402006712	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582402006713	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582402006714	active site
582402006715	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582402006716	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
582402006717	putative active site [active]
582402006718	putative metal binding site [ion binding]; other site
582402006719	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
582402006720	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
582402006721	trimerization site [polypeptide binding]; other site
582402006722	active site
582402006723	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
582402006724	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582402006725	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
582402006726	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402006727	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
582402006728	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582402006729	active site
582402006730	HIGH motif; other site
582402006731	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582402006732	KMSKS motif; other site
582402006733	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
582402006734	tRNA binding surface [nucleotide binding]; other site
582402006735	anticodon binding site; other site
582402006736	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
582402006737	GTP cyclohydrolase I; Provisional; Region: PLN03044
582402006738	active site
582402006739	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402006740	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402006741	non-specific DNA binding site [nucleotide binding]; other site
582402006742	salt bridge; other site
582402006743	sequence-specific DNA binding site [nucleotide binding]; other site
582402006744	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
582402006745	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
582402006746	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
582402006747	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
582402006748	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582402006749	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582402006750	RNA binding surface [nucleotide binding]; other site
582402006751	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582402006752	active site
582402006753	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402006754	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402006755	dimer interface [polypeptide binding]; other site
582402006756	putative CheW interface [polypeptide binding]; other site
582402006757	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
582402006758	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582402006759	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402006760	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402006761	DNA binding residues [nucleotide binding]
582402006762	C factor cell-cell signaling protein; Provisional; Region: PRK09009
582402006763	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006764	NAD(P) binding site [chemical binding]; other site
582402006765	active site
582402006766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402006767	NAD(P) binding site [chemical binding]; other site
582402006768	active site
582402006769	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
582402006770	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
582402006771	GDP-binding site [chemical binding]; other site
582402006772	ACT binding site; other site
582402006773	IMP binding site; other site
582402006774	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
582402006775	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
582402006776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402006777	Walker A motif; other site
582402006778	ATP binding site [chemical binding]; other site
582402006779	Walker B motif; other site
582402006780	arginine finger; other site
582402006781	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
582402006782	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
582402006783	active site
582402006784	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582402006785	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
582402006786	TolR protein; Region: tolR; TIGR02801
582402006787	TolA protein; Region: tolA_full; TIGR02794
582402006788	TolB amino-terminal domain; Region: TolB_N; pfam04052
582402006789	translocation protein TolB; Provisional; Region: tolB; PRK05137
582402006790	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582402006791	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582402006792	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582402006793	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582402006794	ligand binding site [chemical binding]; other site
582402006795	Protein of unknown function DUF16; Region: DUF16; pfam01519
582402006796	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
582402006797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402006798	binding surface
582402006799	TPR motif; other site
582402006800	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
582402006801	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
582402006802	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
582402006803	Ligand Binding Site [chemical binding]; other site
582402006804	FtsH Extracellular; Region: FtsH_ext; pfam06480
582402006805	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
582402006806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402006807	Walker A motif; other site
582402006808	ATP binding site [chemical binding]; other site
582402006809	Walker B motif; other site
582402006810	arginine finger; other site
582402006811	Peptidase family M41; Region: Peptidase_M41; pfam01434
582402006812	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
582402006813	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
582402006814	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
582402006815	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
582402006816	dihydropteroate synthase; Region: DHPS; TIGR01496
582402006817	substrate binding pocket [chemical binding]; other site
582402006818	dimer interface [polypeptide binding]; other site
582402006819	inhibitor binding site; inhibition site
582402006820	TIR domain; Region: TIR_2; pfam13676
582402006821	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
582402006822	dimer interface [polypeptide binding]; other site
582402006823	substrate binding site [chemical binding]; other site
582402006824	ATP binding site [chemical binding]; other site
582402006825	Protein of unknown function, DUF606; Region: DUF606; pfam04657
582402006826	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
582402006827	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
582402006828	heme-binding site [chemical binding]; other site
582402006829	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402006830	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402006831	dimer interface [polypeptide binding]; other site
582402006832	putative CheW interface [polypeptide binding]; other site
582402006833	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
582402006834	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402006835	catalytic residue [active]
582402006836	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539
582402006837	metal binding site [ion binding]; metal-binding site
582402006838	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
582402006839	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
582402006840	ligand binding site [chemical binding]; other site
582402006841	NAD binding site [chemical binding]; other site
582402006842	dimerization interface [polypeptide binding]; other site
582402006843	catalytic site [active]
582402006844	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
582402006845	putative L-serine binding site [chemical binding]; other site
582402006846	Predicted membrane protein [Function unknown]; Region: COG2860
582402006847	UPF0126 domain; Region: UPF0126; pfam03458
582402006848	UPF0126 domain; Region: UPF0126; pfam03458
582402006849	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
582402006850	RuvA N terminal domain; Region: RuvA_N; pfam01330
582402006851	Mor transcription activator family; Region: Mor; cl02360
582402006852	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
582402006853	active site
582402006854	putative DNA-binding cleft [nucleotide binding]; other site
582402006855	dimer interface [polypeptide binding]; other site
582402006856	hypothetical protein; Provisional; Region: PRK05170
582402006857	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
582402006858	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
582402006859	active site
582402006860	substrate binding site [chemical binding]; other site
582402006861	metal binding site [ion binding]; metal-binding site
582402006862	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
582402006863	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
582402006864	glutaminase active site [active]
582402006865	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
582402006866	dimer interface [polypeptide binding]; other site
582402006867	active site
582402006868	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
582402006869	dimer interface [polypeptide binding]; other site
582402006870	active site
582402006871	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
582402006872	active site
582402006873	tetramer interface; other site
582402006874	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
582402006875	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
582402006876	acetylornithine deacetylase; Provisional; Region: PRK07522
582402006877	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
582402006878	metal binding site [ion binding]; metal-binding site
582402006879	putative dimer interface [polypeptide binding]; other site
582402006880	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
582402006881	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
582402006882	C-terminal domain interface [polypeptide binding]; other site
582402006883	GSH binding site (G-site) [chemical binding]; other site
582402006884	dimer interface [polypeptide binding]; other site
582402006885	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582402006886	N-terminal domain interface [polypeptide binding]; other site
582402006887	dimer interface [polypeptide binding]; other site
582402006888	substrate binding pocket (H-site) [chemical binding]; other site
582402006889	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402006890	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
582402006891	C-terminal domain interface [polypeptide binding]; other site
582402006892	GSH binding site (G-site) [chemical binding]; other site
582402006893	dimer interface [polypeptide binding]; other site
582402006894	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
582402006895	N-terminal domain interface [polypeptide binding]; other site
582402006896	dimer interface [polypeptide binding]; other site
582402006897	substrate binding pocket (H-site) [chemical binding]; other site
582402006898	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
582402006899	Cation efflux family; Region: Cation_efflux; cl00316
582402006900	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
582402006901	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
582402006902	Domain of unknown function DUF20; Region: UPF0118; pfam01594
582402006903	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
582402006904	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582402006905	Low molecular weight phosphatase family; Region: LMWPc; cl00105
582402006906	active site
582402006907	GTP-binding protein LepA; Provisional; Region: PRK05433
582402006908	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
582402006909	G1 box; other site
582402006910	putative GEF interaction site [polypeptide binding]; other site
582402006911	GTP/Mg2+ binding site [chemical binding]; other site
582402006912	Switch I region; other site
582402006913	G2 box; other site
582402006914	G3 box; other site
582402006915	Switch II region; other site
582402006916	G4 box; other site
582402006917	G5 box; other site
582402006918	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
582402006919	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
582402006920	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
582402006921	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
582402006922	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
582402006923	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
582402006924	methionine sulfoxide reductase A; Provisional; Region: PRK00058
582402006925	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402006926	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402006927	DNA binding site [nucleotide binding]
582402006928	domain linker motif; other site
582402006929	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402006930	putative dimerization interface [polypeptide binding]; other site
582402006931	putative ligand binding site [chemical binding]; other site
582402006932	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006933	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402006934	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006935	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006936	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006937	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006938	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402006939	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402006940	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402006941	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
582402006942	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
582402006943	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402006944	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402006945	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
582402006946	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402006947	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402006948	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
582402006949	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
582402006950	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402006951	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402006952	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402006953	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006954	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402006955	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
582402006956	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
582402006957	active site
582402006958	catalytic site [active]
582402006959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402006960	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
582402006961	Putative esterase; Region: Esterase; pfam00756
582402006962	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
582402006963	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
582402006964	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
582402006965	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
582402006966	active site
582402006967	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
582402006968	active site
582402006969	catalytic site [active]
582402006970	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
582402006971	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
582402006972	active site
582402006973	catalytic site [active]
582402006974	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402006975	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402006976	DNA binding site [nucleotide binding]
582402006977	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
582402006978	putative dimerization interface [polypeptide binding]; other site
582402006979	putative ligand binding site [chemical binding]; other site
582402006980	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
582402006981	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582402006982	catalytic loop [active]
582402006983	iron binding site [ion binding]; other site
582402006984	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582402006985	Cytochrome P450; Region: p450; cl12078
582402006986	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
582402006987	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
582402006988	NAD(P) binding site [chemical binding]; other site
582402006989	catalytic residues [active]
582402006990	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582402006991	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
582402006992	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
582402006993	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
582402006994	dimer interface [polypeptide binding]; other site
582402006995	acyl-activating enzyme (AAE) consensus motif; other site
582402006996	putative active site [active]
582402006997	AMP binding site [chemical binding]; other site
582402006998	putative CoA binding site [chemical binding]; other site
582402006999	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402007000	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582402007001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007002	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007003	short chain dehydrogenase; Provisional; Region: PRK08278
582402007004	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
582402007005	NAD(P) binding site [chemical binding]; other site
582402007006	homodimer interface [polypeptide binding]; other site
582402007007	active site
582402007008	enoyl-CoA hydratase; Provisional; Region: PRK06142
582402007009	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402007010	substrate binding site [chemical binding]; other site
582402007011	oxyanion hole (OAH) forming residues; other site
582402007012	trimer interface [polypeptide binding]; other site
582402007013	Predicted transcriptional regulators [Transcription]; Region: COG1695
582402007014	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
582402007015	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
582402007016	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
582402007017	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402007018	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007019	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007020	N-terminal plug; other site
582402007021	ligand-binding site [chemical binding]; other site
582402007022	TPR repeat; Region: TPR_11; pfam13414
582402007023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402007024	TPR motif; other site
582402007025	binding surface
582402007026	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
582402007027	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402007028	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402007029	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
582402007030	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
582402007031	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
582402007032	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
582402007033	Walker A/P-loop; other site
582402007034	ATP binding site [chemical binding]; other site
582402007035	Q-loop/lid; other site
582402007036	ABC transporter signature motif; other site
582402007037	Walker B; other site
582402007038	D-loop; other site
582402007039	H-loop/switch region; other site
582402007040	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
582402007041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582402007042	dimer interface [polypeptide binding]; other site
582402007043	conserved gate region; other site
582402007044	putative PBP binding loops; other site
582402007045	ABC-ATPase subunit interface; other site
582402007046	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
582402007047	Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112
582402007048	active site
582402007049	dimer interface [polypeptide binding]; other site
582402007050	PhoD-like phosphatase; Region: PhoD; pfam09423
582402007051	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
582402007052	putative active site [active]
582402007053	putative metal binding site [ion binding]; other site
582402007054	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
582402007055	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007056	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007057	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
582402007058	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
582402007059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402007060	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
582402007061	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
582402007062	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
582402007063	putative active site [active]
582402007064	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
582402007065	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
582402007066	putative active site [active]
582402007067	putative PHP Thumb interface [polypeptide binding]; other site
582402007068	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
582402007069	generic binding surface I; other site
582402007070	generic binding surface II; other site
582402007071	DNA Polymerase Y-family; Region: PolY_like; cd03468
582402007072	active site
582402007073	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
582402007074	DNA binding site [nucleotide binding]
582402007075	Uncharacterized conserved protein [Function unknown]; Region: COG4544
582402007076	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
582402007077	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
582402007078	dimer interface [polypeptide binding]; other site
582402007079	NADP binding site [chemical binding]; other site
582402007080	catalytic residues [active]
582402007081	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007082	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007083	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007084	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
582402007085	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
582402007086	putative active site [active]
582402007087	catalytic residue [active]
582402007088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007090	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
582402007091	putative dimerization interface [polypeptide binding]; other site
582402007092	putative substrate binding pocket [chemical binding]; other site
582402007093	D-galactonate transporter; Region: 2A0114; TIGR00893
582402007094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007095	putative substrate translocation pore; other site
582402007096	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
582402007097	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
582402007098	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
582402007099	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
582402007100	putative active site pocket [active]
582402007101	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
582402007102	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
582402007103	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582402007104	FAD binding site [chemical binding]; other site
582402007105	substrate binding pocket [chemical binding]; other site
582402007106	catalytic base [active]
582402007107	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
582402007108	CoA-transferase family III; Region: CoA_transf_3; pfam02515
582402007109	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007110	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007111	N-terminal plug; other site
582402007112	ligand-binding site [chemical binding]; other site
582402007113	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
582402007114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007115	putative substrate translocation pore; other site
582402007116	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
582402007117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007118	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402007119	dimerization interface [polypeptide binding]; other site
582402007120	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402007121	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402007122	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
582402007123	putative aminotransferase; Validated; Region: PRK07480
582402007124	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582402007125	inhibitor-cofactor binding pocket; inhibition site
582402007126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402007127	catalytic residue [active]
582402007128	succinic semialdehyde dehydrogenase; Region: PLN02278
582402007129	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
582402007130	tetramerization interface [polypeptide binding]; other site
582402007131	NAD(P) binding site [chemical binding]; other site
582402007132	catalytic residues [active]
582402007133	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402007134	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402007135	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402007136	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
582402007137	putative DNA binding site [nucleotide binding]; other site
582402007138	putative Zn2+ binding site [ion binding]; other site
582402007139	AsnC family; Region: AsnC_trans_reg; pfam01037
582402007140	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
582402007141	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
582402007142	hexamer interface [polypeptide binding]; other site
582402007143	ligand binding site [chemical binding]; other site
582402007144	putative active site [active]
582402007145	NAD(P) binding site [chemical binding]; other site
582402007146	Right handed beta helix region; Region: Beta_helix; pfam13229
582402007147	Uncharacterized conserved protein [Function unknown]; Region: COG1262
582402007148	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
582402007149	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582402007150	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402007151	Amidohydrolase; Region: Amidohydro_4; pfam13147
582402007152	active site
582402007153	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
582402007154	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582402007155	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
582402007156	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
582402007157	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007158	N-terminal plug; other site
582402007159	ligand-binding site [chemical binding]; other site
582402007160	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
582402007161	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582402007162	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
582402007163	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
582402007164	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
582402007165	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
582402007166	Isochorismatase family; Region: Isochorismatase; pfam00857
582402007167	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
582402007168	catalytic triad [active]
582402007169	conserved cis-peptide bond; other site
582402007170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007171	D-galactonate transporter; Region: 2A0114; TIGR00893
582402007172	putative substrate translocation pore; other site
582402007173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007174	putative substrate translocation pore; other site
582402007175	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
582402007176	pyrimidine utilization protein A; Region: RutA; TIGR03612
582402007177	active site
582402007178	dimer interface [polypeptide binding]; other site
582402007179	non-prolyl cis peptide bond; other site
582402007180	insertion regions; other site
582402007181	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
582402007182	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
582402007183	putative metal binding site [ion binding]; other site
582402007184	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
582402007185	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
582402007186	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402007187	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402007188	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
582402007189	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
582402007190	active site
582402007191	iron coordination sites [ion binding]; other site
582402007192	substrate binding pocket [chemical binding]; other site
582402007193	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007194	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007195	N-terminal plug; other site
582402007196	ligand-binding site [chemical binding]; other site
582402007197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007198	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402007199	putative substrate translocation pore; other site
582402007200	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
582402007201	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
582402007202	putative FMN binding site [chemical binding]; other site
582402007203	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
582402007204	active site
582402007205	iron coordination sites [ion binding]; other site
582402007206	substrate binding pocket [chemical binding]; other site
582402007207	short chain dehydrogenase; Provisional; Region: PRK06180
582402007208	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
582402007209	NADP binding site [chemical binding]; other site
582402007210	active site
582402007211	steroid binding site; other site
582402007212	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
582402007213	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
582402007214	substrate binding site [chemical binding]; other site
582402007215	dimer interface [polypeptide binding]; other site
582402007216	ATP binding site [chemical binding]; other site
582402007217	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
582402007218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007219	putative substrate translocation pore; other site
582402007220	active site
582402007221	metal binding site [ion binding]; metal-binding site
582402007222	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
582402007223	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582402007224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582402007225	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
582402007226	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
582402007227	[2Fe-2S] cluster binding site [ion binding]; other site
582402007228	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
582402007229	putative alpha subunit interface [polypeptide binding]; other site
582402007230	putative active site [active]
582402007231	putative substrate binding site [chemical binding]; other site
582402007232	Fe binding site [ion binding]; other site
582402007233	Helix-turn-helix domain; Region: HTH_18; pfam12833
582402007234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582402007235	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
582402007236	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
582402007237	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
582402007238	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
582402007239	putative active site [active]
582402007240	metal binding site [ion binding]; metal-binding site
582402007241	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
582402007242	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
582402007243	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
582402007244	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
582402007245	classical (c) SDRs; Region: SDR_c; cd05233
582402007246	NAD(P) binding site [chemical binding]; other site
582402007247	active site
582402007248	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582402007249	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
582402007250	NAD(P) binding site [chemical binding]; other site
582402007251	catalytic residues [active]
582402007252	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
582402007253	CoA-transferase family III; Region: CoA_transf_3; pfam02515
582402007254	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
582402007255	Transcriptional regulator [Transcription]; Region: IclR; COG1414
582402007256	Bacterial transcriptional regulator; Region: IclR; pfam01614
582402007257	hypothetical protein; Validated; Region: PRK09104
582402007258	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
582402007259	metal binding site [ion binding]; metal-binding site
582402007260	putative dimer interface [polypeptide binding]; other site
582402007261	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
582402007262	Na binding site [ion binding]; other site
582402007263	Protein of unknown function (DUF917); Region: DUF917; pfam06032
582402007264	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
582402007265	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
582402007266	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
582402007267	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
582402007268	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
582402007269	active site
582402007270	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
582402007271	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
582402007272	metal binding site [ion binding]; metal-binding site
582402007273	putative dimer interface [polypeptide binding]; other site
582402007274	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
582402007275	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
582402007276	active site
582402007277	benzoate transport; Region: 2A0115; TIGR00895
582402007278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007280	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582402007281	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
582402007282	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007283	N-terminal plug; other site
582402007284	ligand-binding site [chemical binding]; other site
582402007285	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
582402007286	AAA ATPase domain; Region: AAA_16; pfam13191
582402007287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582402007288	DNA binding residues [nucleotide binding]
582402007289	dimerization interface [polypeptide binding]; other site
582402007290	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
582402007291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
582402007292	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
582402007293	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582402007294	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402007295	DNA-binding site [nucleotide binding]; DNA binding site
582402007296	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402007297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402007298	homodimer interface [polypeptide binding]; other site
582402007299	catalytic residue [active]
582402007300	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582402007301	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
582402007302	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402007303	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
582402007304	C-terminal domain interface [polypeptide binding]; other site
582402007305	GSH binding site (G-site) [chemical binding]; other site
582402007306	dimer interface [polypeptide binding]; other site
582402007307	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582402007308	dimer interface [polypeptide binding]; other site
582402007309	N-terminal domain interface [polypeptide binding]; other site
582402007310	substrate binding pocket (H-site) [chemical binding]; other site
582402007311	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
582402007312	Sulfatase; Region: Sulfatase; pfam00884
582402007313	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582402007314	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582402007315	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402007316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402007317	Amidohydrolase; Region: Amidohydro_2; pfam04909
582402007318	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402007319	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402007320	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007321	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007322	N-terminal plug; other site
582402007323	ligand-binding site [chemical binding]; other site
582402007324	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
582402007325	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582402007326	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582402007327	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007328	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
582402007329	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
582402007330	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
582402007331	putative active site [active]
582402007332	putative metal binding site [ion binding]; other site
582402007333	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
582402007334	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
582402007335	acyl-activating enzyme (AAE) consensus motif; other site
582402007336	putative AMP binding site [chemical binding]; other site
582402007337	putative active site [active]
582402007338	putative CoA binding site [chemical binding]; other site
582402007339	The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949
582402007340	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
582402007341	putative active site [active]
582402007342	Fe(II) binding site [ion binding]; other site
582402007343	putative dimer interface [polypeptide binding]; other site
582402007344	putative tetramer interface [polypeptide binding]; other site
582402007345	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
582402007346	dimer interface [polypeptide binding]; other site
582402007347	tetramer interface [polypeptide binding]; other site
582402007348	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
582402007349	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
582402007350	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
582402007351	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007352	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007353	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
582402007354	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007356	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007357	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007358	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402007359	dimerization interface [polypeptide binding]; other site
582402007360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
582402007361	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
582402007362	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
582402007363	inhibitor binding site; inhibition site
582402007364	active site
582402007365	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582402007366	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
582402007367	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
582402007368	dimer interface [polypeptide binding]; other site
582402007369	NADP binding site [chemical binding]; other site
582402007370	catalytic residues [active]
582402007371	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007372	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007373	Amidohydrolase; Region: Amidohydro_2; pfam04909
582402007374	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
582402007375	Amidohydrolase; Region: Amidohydro_2; pfam04909
582402007376	active site
582402007377	D-galactonate transporter; Region: 2A0114; TIGR00893
582402007378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007379	putative substrate translocation pore; other site
582402007380	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; Region: 3MGA_Dioxygenase; cd07366
582402007381	putative active site [active]
582402007382	putative Fe(II) binding site [ion binding]; other site
582402007383	putative dimer interface [polypeptide binding]; other site
582402007384	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
582402007385	putative tetramer interface [polypeptide binding]; other site
582402007386	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
582402007387	hypothetical protein; Validated; Region: PRK07586
582402007388	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
582402007389	PYR/PP interface [polypeptide binding]; other site
582402007390	dimer interface [polypeptide binding]; other site
582402007391	TPP binding site [chemical binding]; other site
582402007392	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
582402007393	TPP-binding site [chemical binding]; other site
582402007394	dimer interface [polypeptide binding]; other site
582402007395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007398	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402007399	dimerization interface [polypeptide binding]; other site
582402007400	Transmembrane secretion effector; Region: MFS_3; pfam05977
582402007401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007402	putative substrate translocation pore; other site
582402007403	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
582402007404	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
582402007405	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582402007406	translocation protein TolB; Provisional; Region: tolB; PRK00178
582402007407	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
582402007408	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
582402007409	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007410	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007411	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007412	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
582402007413	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402007414	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582402007415	DNA binding residues [nucleotide binding]
582402007416	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582402007417	FecR protein; Region: FecR; pfam04773
582402007418	Secretin and TonB N terminus short domain; Region: STN; smart00965
582402007419	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007420	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007421	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007422	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
582402007423	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582402007424	substrate binding pocket [chemical binding]; other site
582402007425	putative pectinesterase; Region: PLN02432; cl01911
582402007426	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
582402007427	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
582402007428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402007429	TPR motif; other site
582402007430	TPR repeat; Region: TPR_11; pfam13414
582402007431	binding surface
582402007432	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402007433	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
582402007434	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402007435	active site
582402007436	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
582402007437	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
582402007438	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402007439	active site
582402007440	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
582402007441	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
582402007442	active site
582402007443	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582402007444	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007445	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007446	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402007447	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402007448	putative DNA binding site [nucleotide binding]; other site
582402007449	putative Zn2+ binding site [ion binding]; other site
582402007450	AsnC family; Region: AsnC_trans_reg; pfam01037
582402007451	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
582402007452	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
582402007453	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402007454	catalytic residue [active]
582402007455	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
582402007456	homotrimer interaction site [polypeptide binding]; other site
582402007457	putative active site [active]
582402007458	succinic semialdehyde dehydrogenase; Region: PLN02278
582402007459	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
582402007460	tetramerization interface [polypeptide binding]; other site
582402007461	NAD(P) binding site [chemical binding]; other site
582402007462	catalytic residues [active]
582402007463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402007464	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402007465	dimer interface [polypeptide binding]; other site
582402007466	phosphorylation site [posttranslational modification]
582402007467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402007468	ATP binding site [chemical binding]; other site
582402007469	Mg2+ binding site [ion binding]; other site
582402007470	G-X-G motif; other site
582402007471	Response regulator receiver domain; Region: Response_reg; pfam00072
582402007472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007473	active site
582402007474	phosphorylation site [posttranslational modification]
582402007475	intermolecular recognition site; other site
582402007476	dimerization interface [polypeptide binding]; other site
582402007477	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
582402007478	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007479	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007480	N-terminal plug; other site
582402007481	ligand-binding site [chemical binding]; other site
582402007482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007483	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402007484	putative substrate translocation pore; other site
582402007485	maleylacetoacetate isomerase; Region: maiA; TIGR01262
582402007486	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
582402007487	C-terminal domain interface [polypeptide binding]; other site
582402007488	GSH binding site (G-site) [chemical binding]; other site
582402007489	putative dimer interface [polypeptide binding]; other site
582402007490	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
582402007491	dimer interface [polypeptide binding]; other site
582402007492	N-terminal domain interface [polypeptide binding]; other site
582402007493	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
582402007494	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582402007495	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007496	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
582402007497	Cupin domain; Region: Cupin_2; pfam07883
582402007498	Transcriptional regulator [Transcription]; Region: IclR; COG1414
582402007499	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
582402007500	Bacterial transcriptional regulator; Region: IclR; pfam01614
582402007501	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402007502	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582402007503	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
582402007504	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402007505	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
582402007506	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
582402007507	Bacterial sugar transferase; Region: Bac_transf; pfam02397
582402007508	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
582402007509	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
582402007510	Substrate binding site; other site
582402007511	Cupin domain; Region: Cupin_2; cl17218
582402007512	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
582402007513	dimerization interface [polypeptide binding]; other site
582402007514	putative active cleft [active]
582402007515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402007516	dimer interface [polypeptide binding]; other site
582402007517	phosphorylation site [posttranslational modification]
582402007518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402007519	ATP binding site [chemical binding]; other site
582402007520	Mg2+ binding site [ion binding]; other site
582402007521	G-X-G motif; other site
582402007522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007523	active site
582402007524	phosphorylation site [posttranslational modification]
582402007525	intermolecular recognition site; other site
582402007526	dimerization interface [polypeptide binding]; other site
582402007527	Response regulator receiver domain; Region: Response_reg; pfam00072
582402007528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007529	active site
582402007530	phosphorylation site [posttranslational modification]
582402007531	intermolecular recognition site; other site
582402007532	dimerization interface [polypeptide binding]; other site
582402007533	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582402007534	putative binding surface; other site
582402007535	active site
582402007536	Response regulator receiver domain; Region: Response_reg; pfam00072
582402007537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007538	active site
582402007539	phosphorylation site [posttranslational modification]
582402007540	intermolecular recognition site; other site
582402007541	dimerization interface [polypeptide binding]; other site
582402007542	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
582402007543	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
582402007544	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
582402007545	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402007546	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
582402007547	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402007548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402007549	Walker A/P-loop; other site
582402007550	ATP binding site [chemical binding]; other site
582402007551	Q-loop/lid; other site
582402007552	ABC transporter signature motif; other site
582402007553	Walker B; other site
582402007554	D-loop; other site
582402007555	H-loop/switch region; other site
582402007556	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
582402007557	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402007558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402007559	Walker A/P-loop; other site
582402007560	ATP binding site [chemical binding]; other site
582402007561	Q-loop/lid; other site
582402007562	ABC transporter signature motif; other site
582402007563	Walker B; other site
582402007564	D-loop; other site
582402007565	H-loop/switch region; other site
582402007566	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582402007567	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
582402007568	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
582402007569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402007570	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402007571	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
582402007572	dimerization interface [polypeptide binding]; other site
582402007573	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
582402007574	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
582402007575	heme binding site [chemical binding]; other site
582402007576	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
582402007577	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
582402007578	aromatic arch; other site
582402007579	DCoH dimer interaction site [polypeptide binding]; other site
582402007580	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
582402007581	DCoH tetramer interaction site [polypeptide binding]; other site
582402007582	substrate binding site [chemical binding]; other site
582402007583	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
582402007584	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402007585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402007586	homodimer interface [polypeptide binding]; other site
582402007587	catalytic residue [active]
582402007588	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007589	maleylacetoacetate isomerase; Region: maiA; TIGR01262
582402007590	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402007591	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582402007592	N-terminal domain interface [polypeptide binding]; other site
582402007593	dimer interface [polypeptide binding]; other site
582402007594	substrate binding pocket (H-site) [chemical binding]; other site
582402007595	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
582402007596	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402007597	Zn binding site [ion binding]; other site
582402007598	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
582402007599	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
582402007600	dimer interface [polypeptide binding]; other site
582402007601	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
582402007602	active site
582402007603	Fe binding site [ion binding]; other site
582402007604	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
582402007605	cofactor binding site; other site
582402007606	metal binding site [ion binding]; metal-binding site
582402007607	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402007608	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
582402007609	AsnC family; Region: AsnC_trans_reg; pfam01037
582402007610	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
582402007611	tyrosine/nicotianamine family aminotransferase; Region: tyr_nico_aTase; TIGR01265
582402007612	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582402007613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582402007614	homodimer interface [polypeptide binding]; other site
582402007615	catalytic residue [active]
582402007616	amino acid transporter; Region: 2A0306; TIGR00909
582402007617	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007618	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007619	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007620	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
582402007621	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
582402007622	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
582402007623	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
582402007624	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
582402007625	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
582402007626	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582402007627	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582402007628	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402007629	catalytic residue [active]
582402007630	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
582402007631	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
582402007632	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402007633	Amidohydrolase; Region: Amidohydro_4; pfam13147
582402007634	active site
582402007635	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
582402007636	homotrimer interaction site [polypeptide binding]; other site
582402007637	putative active site [active]
582402007638	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582402007639	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582402007640	putative DNA binding site [nucleotide binding]; other site
582402007641	putative Zn2+ binding site [ion binding]; other site
582402007642	AsnC family; Region: AsnC_trans_reg; pfam01037
582402007643	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
582402007644	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
582402007645	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
582402007646	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
582402007647	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582402007648	phosphate binding site [ion binding]; other site
582402007649	Domain of unknown function (DUF718); Region: DUF718; cl01281
582402007650	short chain dehydrogenase; Provisional; Region: PRK06138
582402007651	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
582402007652	NAD binding site [chemical binding]; other site
582402007653	homotetramer interface [polypeptide binding]; other site
582402007654	homodimer interface [polypeptide binding]; other site
582402007655	active site
582402007656	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582402007657	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582402007658	active site
582402007659	catalytic tetrad [active]
582402007660	Transcriptional regulators [Transcription]; Region: GntR; COG1802
582402007661	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402007662	DNA-binding site [nucleotide binding]; DNA binding site
582402007663	FCD domain; Region: FCD; pfam07729
582402007664	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
582402007665	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
582402007666	active site pocket [active]
582402007667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007668	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582402007669	putative substrate translocation pore; other site
582402007670	Right handed beta helix region; Region: Beta_helix; pfam13229
582402007671	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
582402007672	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
582402007673	dimerization interface [polypeptide binding]; other site
582402007674	ligand binding site [chemical binding]; other site
582402007675	NADP binding site [chemical binding]; other site
582402007676	catalytic site [active]
582402007677	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582402007678	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007679	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
582402007680	Amidohydrolase; Region: Amidohydro_2; pfam04909
582402007681	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007682	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007683	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007684	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402007685	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
582402007686	DNA binding site [nucleotide binding]
582402007687	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
582402007688	putative ligand binding site [chemical binding]; other site
582402007689	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
582402007690	active site
582402007691	catalytic residues [active]
582402007692	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402007693	classical (c) SDRs; Region: SDR_c; cd05233
582402007694	NAD(P) binding site [chemical binding]; other site
582402007695	active site
582402007696	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
582402007697	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402007698	substrate binding site [chemical binding]; other site
582402007699	oxyanion hole (OAH) forming residues; other site
582402007700	trimer interface [polypeptide binding]; other site
582402007701	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
582402007702	CoA-transferase family III; Region: CoA_transf_3; pfam02515
582402007703	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
582402007704	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
582402007705	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007706	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
582402007707	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
582402007708	dimer interface [polypeptide binding]; other site
582402007709	NADP binding site [chemical binding]; other site
582402007710	catalytic residues [active]
582402007711	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007712	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007713	N-terminal plug; other site
582402007714	ligand-binding site [chemical binding]; other site
582402007715	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
582402007716	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
582402007717	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582402007718	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402007719	active site
582402007720	enoyl-CoA hydratase; Provisional; Region: PRK05862
582402007721	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402007722	substrate binding site [chemical binding]; other site
582402007723	oxyanion hole (OAH) forming residues; other site
582402007724	trimer interface [polypeptide binding]; other site
582402007725	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
582402007726	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
582402007727	tetrameric interface [polypeptide binding]; other site
582402007728	NAD binding site [chemical binding]; other site
582402007729	catalytic residues [active]
582402007730	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
582402007731	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
582402007732	substrate binding site [chemical binding]; other site
582402007733	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
582402007734	substrate binding site [chemical binding]; other site
582402007735	ligand binding site [chemical binding]; other site
582402007736	Secretin and TonB N terminus short domain; Region: STN; smart00965
582402007737	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007738	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007739	N-terminal plug; other site
582402007740	ligand-binding site [chemical binding]; other site
582402007741	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007742	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007743	N-terminal plug; other site
582402007744	ligand-binding site [chemical binding]; other site
582402007745	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582402007746	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582402007747	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582402007748	catalytic residue [active]
582402007749	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
582402007750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582402007751	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
582402007752	ATP-binding site [chemical binding]; other site
582402007753	Gluconate-6-phosphate binding site [chemical binding]; other site
582402007754	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
582402007755	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
582402007756	active site
582402007757	intersubunit interface [polypeptide binding]; other site
582402007758	catalytic residue [active]
582402007759	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
582402007760	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
582402007761	substrate binding site [chemical binding]; other site
582402007762	ATP binding site [chemical binding]; other site
582402007763	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007764	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007765	Tetratricopeptide repeat; Region: TPR_16; pfam13432
582402007766	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402007767	binding surface
582402007768	TPR motif; other site
582402007769	TPR repeat; Region: TPR_11; pfam13414
582402007770	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
582402007771	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
582402007772	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
582402007773	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
582402007774	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582402007775	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
582402007776	putative ligand binding site [chemical binding]; other site
582402007777	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
582402007778	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
582402007779	TM-ABC transporter signature motif; other site
582402007780	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
582402007781	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
582402007782	TM-ABC transporter signature motif; other site
582402007783	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
582402007784	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
582402007785	Walker A/P-loop; other site
582402007786	ATP binding site [chemical binding]; other site
582402007787	Q-loop/lid; other site
582402007788	ABC transporter signature motif; other site
582402007789	Walker B; other site
582402007790	D-loop; other site
582402007791	H-loop/switch region; other site
582402007792	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
582402007793	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
582402007794	Walker A/P-loop; other site
582402007795	ATP binding site [chemical binding]; other site
582402007796	Q-loop/lid; other site
582402007797	ABC transporter signature motif; other site
582402007798	Walker B; other site
582402007799	D-loop; other site
582402007800	H-loop/switch region; other site
582402007801	Response regulator receiver domain; Region: Response_reg; pfam00072
582402007802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007803	active site
582402007804	phosphorylation site [posttranslational modification]
582402007805	intermolecular recognition site; other site
582402007806	dimerization interface [polypeptide binding]; other site
582402007807	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582402007808	DNA binding residues [nucleotide binding]
582402007809	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
582402007810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402007811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402007812	dimer interface [polypeptide binding]; other site
582402007813	phosphorylation site [posttranslational modification]
582402007814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402007815	ATP binding site [chemical binding]; other site
582402007816	Mg2+ binding site [ion binding]; other site
582402007817	G-X-G motif; other site
582402007818	Response regulator receiver domain; Region: Response_reg; pfam00072
582402007819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007820	active site
582402007821	phosphorylation site [posttranslational modification]
582402007822	intermolecular recognition site; other site
582402007823	dimerization interface [polypeptide binding]; other site
582402007824	agmatinase; Region: agmatinase; TIGR01230
582402007825	Agmatinase-like family; Region: Agmatinase-like; cd09990
582402007826	active site
582402007827	oligomer interface [polypeptide binding]; other site
582402007828	Mn binding site [ion binding]; other site
582402007829	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582402007830	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
582402007831	UreF; Region: UreF; pfam01730
582402007832	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
582402007833	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
582402007834	dimer interface [polypeptide binding]; other site
582402007835	catalytic residues [active]
582402007836	urease subunit alpha; Reviewed; Region: ureC; PRK13207
582402007837	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
582402007838	subunit interactions [polypeptide binding]; other site
582402007839	active site
582402007840	flap region; other site
582402007841	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
582402007842	gamma-beta subunit interface [polypeptide binding]; other site
582402007843	alpha-beta subunit interface [polypeptide binding]; other site
582402007844	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
582402007845	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
582402007846	alpha-gamma subunit interface [polypeptide binding]; other site
582402007847	beta-gamma subunit interface [polypeptide binding]; other site
582402007848	UreD urease accessory protein; Region: UreD; cl00530
582402007849	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007850	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582402007851	N-terminal plug; other site
582402007852	ligand-binding site [chemical binding]; other site
582402007853	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
582402007854	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582402007855	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582402007856	Methylamine utilisation protein MauE; Region: MauE; pfam07291
582402007857	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
582402007858	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582402007859	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
582402007860	GAF domain; Region: GAF; pfam01590
582402007861	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
582402007862	DNA-binding interface [nucleotide binding]; DNA binding site
582402007863	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
582402007864	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582402007865	NAD(P) binding site [chemical binding]; other site
582402007866	catalytic residues [active]
582402007867	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402007868	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402007869	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007870	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007871	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007872	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402007873	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402007874	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
582402007875	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
582402007876	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582402007877	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402007878	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582402007879	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
582402007880	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
582402007881	active site
582402007882	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
582402007883	Transcriptional regulator [Transcription]; Region: IclR; COG1414
582402007884	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
582402007885	Bacterial transcriptional regulator; Region: IclR; pfam01614
582402007886	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402007887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402007888	NAD(P) binding site [chemical binding]; other site
582402007889	active site
582402007890	L-rhamnonate dehydratase; Provisional; Region: PRK15440
582402007891	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
582402007892	metal binding site [ion binding]; metal-binding site
582402007893	substrate binding pocket [chemical binding]; other site
582402007894	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582402007895	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582402007896	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402007897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402007898	NAD(P) binding site [chemical binding]; other site
582402007899	active site
582402007900	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
582402007901	Amidohydrolase; Region: Amidohydro_2; pfam04909
582402007902	active site
582402007903	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
582402007904	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582402007905	phosphate binding site [ion binding]; other site
582402007906	rhamnose-proton symporter; Provisional; Region: PRK13499
582402007907	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
582402007908	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
582402007909	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
582402007910	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
582402007911	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
582402007912	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582402007913	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007914	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007915	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582402007916	Transcriptional regulators [Transcription]; Region: FadR; COG2186
582402007917	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402007918	DNA-binding site [nucleotide binding]; DNA binding site
582402007919	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
582402007920	glucuronate isomerase; Reviewed; Region: PRK02925
582402007921	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
582402007922	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
582402007923	galactarate dehydratase; Region: galactar-dH20; TIGR03248
582402007924	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
582402007925	Autotransporter beta-domain; Region: Autotransporter; pfam03797
582402007926	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582402007927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402007928	NAD(P) binding site [chemical binding]; other site
582402007929	active site
582402007930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402007931	D-galactonate transporter; Region: 2A0114; TIGR00893
582402007932	putative substrate translocation pore; other site
582402007933	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
582402007934	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
582402007935	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
582402007936	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402007937	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007938	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402007939	Transcriptional regulators [Transcription]; Region: FadR; COG2186
582402007940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402007941	DNA-binding site [nucleotide binding]; DNA binding site
582402007942	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
582402007943	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
582402007944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402007945	active site
582402007946	phosphorylation site [posttranslational modification]
582402007947	intermolecular recognition site; other site
582402007948	dimerization interface [polypeptide binding]; other site
582402007949	ANTAR domain; Region: ANTAR; pfam03861
582402007950	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582402007951	NMT1-like family; Region: NMT1_2; pfam13379
582402007952	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
582402007953	active site
582402007954	SAM binding site [chemical binding]; other site
582402007955	homodimer interface [polypeptide binding]; other site
582402007956	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
582402007957	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
582402007958	[4Fe-4S] binding site [ion binding]; other site
582402007959	molybdopterin cofactor binding site; other site
582402007960	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
582402007961	molybdopterin cofactor binding site; other site
582402007962	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582402007963	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
582402007964	[2Fe-2S] cluster binding site [ion binding]; other site
582402007965	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
582402007966	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402007967	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582402007968	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582402007969	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582402007970	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
582402007971	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
582402007972	Walker A/P-loop; other site
582402007973	ATP binding site [chemical binding]; other site
582402007974	Q-loop/lid; other site
582402007975	ABC transporter signature motif; other site
582402007976	Walker B; other site
582402007977	D-loop; other site
582402007978	H-loop/switch region; other site
582402007979	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
582402007980	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
582402007981	Walker A/P-loop; other site
582402007982	ATP binding site [chemical binding]; other site
582402007983	Q-loop/lid; other site
582402007984	ABC transporter signature motif; other site
582402007985	Walker B; other site
582402007986	D-loop; other site
582402007987	H-loop/switch region; other site
582402007988	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
582402007989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582402007990	dimer interface [polypeptide binding]; other site
582402007991	conserved gate region; other site
582402007992	putative PBP binding loops; other site
582402007993	ABC-ATPase subunit interface; other site
582402007994	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582402007995	NMT1-like family; Region: NMT1_2; pfam13379
582402007996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402007997	TPR motif; other site
582402007998	TPR repeat; Region: TPR_11; pfam13414
582402007999	binding surface
582402008000	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
582402008001	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
582402008002	putative active site pocket [active]
582402008003	putative metal binding site [ion binding]; other site
582402008004	Transcriptional regulators [Transcription]; Region: FadR; COG2186
582402008005	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582402008006	DNA-binding site [nucleotide binding]; DNA binding site
582402008007	FCD domain; Region: FCD; pfam07729
582402008008	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
582402008009	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
582402008010	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
582402008011	DctM-like transporters; Region: DctM; pfam06808
582402008012	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
582402008013	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
582402008014	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
582402008015	inhibitor binding site; inhibition site
582402008016	active site
582402008017	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
582402008018	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
582402008019	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
582402008020	Domain of unknown function (DUF303); Region: DUF303; pfam03629
582402008021	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
582402008022	Domain of unknown function (DUF303); Region: DUF303; pfam03629
582402008023	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582402008024	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402008025	PA14 domain; Region: PA14; cl08459
582402008026	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
582402008027	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
582402008028	Trehalose utilisation; Region: ThuA; pfam06283
582402008029	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402008030	Cupin-like domain; Region: Cupin_8; pfam13621
582402008031	SapC; Region: SapC; pfam07277
582402008032	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008033	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008034	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008035	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
582402008036	substrate binding site [chemical binding]; other site
582402008037	active site
582402008038	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
582402008039	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
582402008040	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
582402008041	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402008042	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402008043	DNA binding site [nucleotide binding]
582402008044	domain linker motif; other site
582402008045	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402008046	putative dimerization interface [polypeptide binding]; other site
582402008047	putative ligand binding site [chemical binding]; other site
582402008048	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
582402008049	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
582402008050	active site
582402008051	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
582402008052	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008053	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008054	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402008055	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402008056	Cupin domain; Region: Cupin_2; pfam07883
582402008057	DctM-like transporters; Region: DctM; pfam06808
582402008058	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
582402008059	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
582402008060	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
582402008061	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
582402008062	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
582402008063	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
582402008064	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
582402008065	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
582402008066	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582402008067	substrate binding pocket [chemical binding]; other site
582402008068	catalytic triad [active]
582402008069	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
582402008070	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
582402008071	NADP binding site [chemical binding]; other site
582402008072	homodimer interface [polypeptide binding]; other site
582402008073	active site
582402008074	hypothetical protein; Provisional; Region: PRK09273
582402008075	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
582402008076	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
582402008077	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402008078	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402008079	DNA binding site [nucleotide binding]
582402008080	domain linker motif; other site
582402008081	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402008082	putative dimerization interface [polypeptide binding]; other site
582402008083	putative ligand binding site [chemical binding]; other site
582402008084	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
582402008085	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
582402008086	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
582402008087	N- and C-terminal domain interface [polypeptide binding]; other site
582402008088	active site
582402008089	MgATP binding site [chemical binding]; other site
582402008090	catalytic site [active]
582402008091	metal binding site [ion binding]; metal-binding site
582402008092	glycerol binding site [chemical binding]; other site
582402008093	homotetramer interface [polypeptide binding]; other site
582402008094	homodimer interface [polypeptide binding]; other site
582402008095	FBP binding site [chemical binding]; other site
582402008096	protein IIAGlc interface [polypeptide binding]; other site
582402008097	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
582402008098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
582402008099	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582402008100	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402008101	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402008102	DNA binding site [nucleotide binding]
582402008103	domain linker motif; other site
582402008104	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402008105	putative dimerization interface [polypeptide binding]; other site
582402008106	putative ligand binding site [chemical binding]; other site
582402008107	xylulokinase; Provisional; Region: PRK15027
582402008108	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
582402008109	N- and C-terminal domain interface [polypeptide binding]; other site
582402008110	active site
582402008111	MgATP binding site [chemical binding]; other site
582402008112	catalytic site [active]
582402008113	metal binding site [ion binding]; metal-binding site
582402008114	xylulose binding site [chemical binding]; other site
582402008115	homodimer interface [polypeptide binding]; other site
582402008116	xylose isomerase; Provisional; Region: PRK05474
582402008117	xylose isomerase; Region: xylose_isom_A; TIGR02630
582402008118	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
582402008119	active site
582402008120	intersubunit interactions; other site
582402008121	catalytic residue [active]
582402008122	Pectic acid lyase; Region: Pec_lyase; pfam09492
582402008123	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
582402008124	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
582402008125	TPP-binding site [chemical binding]; other site
582402008126	dimer interface [polypeptide binding]; other site
582402008127	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582402008128	PYR/PP interface [polypeptide binding]; other site
582402008129	dimer interface [polypeptide binding]; other site
582402008130	TPP binding site [chemical binding]; other site
582402008131	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
582402008132	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
582402008133	putative FMN binding site [chemical binding]; other site
582402008134	enoyl-CoA hydratase; Provisional; Region: PRK06142
582402008135	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402008136	substrate binding site [chemical binding]; other site
582402008137	oxyanion hole (OAH) forming residues; other site
582402008138	trimer interface [polypeptide binding]; other site
582402008139	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
582402008140	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
582402008141	active site
582402008142	FMN binding site [chemical binding]; other site
582402008143	2,4-decadienoyl-CoA binding site; other site
582402008144	catalytic residue [active]
582402008145	4Fe-4S cluster binding site [ion binding]; other site
582402008146	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
582402008147	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402008148	SnoaL-like domain; Region: SnoaL_2; pfam12680
582402008149	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
582402008150	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582402008151	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582402008152	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
582402008153	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
582402008154	dimer interface [polypeptide binding]; other site
582402008155	active site
582402008156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402008157	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582402008158	NAD(P) binding site [chemical binding]; other site
582402008159	active site
582402008160	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
582402008161	putative active site [active]
582402008162	putative catalytic site [active]
582402008163	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
582402008164	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
582402008165	active site
582402008166	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
582402008167	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402008168	active site
582402008169	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582402008170	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402008171	active site
582402008172	Phosphotransferase enzyme family; Region: APH; pfam01636
582402008173	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
582402008174	putative active site [active]
582402008175	putative substrate binding site [chemical binding]; other site
582402008176	ATP binding site [chemical binding]; other site
582402008177	short chain dehydrogenase; Provisional; Region: PRK07035
582402008178	classical (c) SDRs; Region: SDR_c; cd05233
582402008179	NAD(P) binding site [chemical binding]; other site
582402008180	active site
582402008181	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
582402008182	classical (c) SDRs; Region: SDR_c; cd05233
582402008183	NAD(P) binding site [chemical binding]; other site
582402008184	active site
582402008185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
582402008186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402008187	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582402008188	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
582402008189	NAD(P) binding site [chemical binding]; other site
582402008190	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
582402008191	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
582402008192	putative [Fe4-S4] binding site [ion binding]; other site
582402008193	putative molybdopterin cofactor binding site [chemical binding]; other site
582402008194	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
582402008195	putative molybdopterin cofactor binding site; other site
582402008196	putative S-transferase; Provisional; Region: PRK11752
582402008197	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
582402008198	C-terminal domain interface [polypeptide binding]; other site
582402008199	GSH binding site (G-site) [chemical binding]; other site
582402008200	dimer interface [polypeptide binding]; other site
582402008201	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
582402008202	dimer interface [polypeptide binding]; other site
582402008203	N-terminal domain interface [polypeptide binding]; other site
582402008204	active site
582402008205	Pirin-related protein [General function prediction only]; Region: COG1741
582402008206	Pirin; Region: Pirin; pfam02678
582402008207	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
582402008208	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582402008209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402008210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402008211	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582402008212	putative effector binding pocket; other site
582402008213	dimerization interface [polypeptide binding]; other site
582402008214	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
582402008215	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582402008216	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
582402008217	active site
582402008218	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
582402008219	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
582402008220	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582402008221	active site
582402008222	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
582402008223	enoyl-CoA hydratase; Provisional; Region: PRK06688
582402008224	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402008225	substrate binding site [chemical binding]; other site
582402008226	oxyanion hole (OAH) forming residues; other site
582402008227	trimer interface [polypeptide binding]; other site
582402008228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
582402008229	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
582402008230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402008231	Walker A motif; other site
582402008232	ATP binding site [chemical binding]; other site
582402008233	Walker B motif; other site
582402008234	arginine finger; other site
582402008235	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
582402008236	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
582402008237	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
582402008238	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
582402008239	short chain dehydrogenase; Provisional; Region: PRK08251
582402008240	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402008241	NAD(P) binding site [chemical binding]; other site
582402008242	active site
582402008243	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402008244	catalytic core [active]
582402008245	short chain dehydrogenase; Provisional; Region: PRK05650
582402008246	classical (c) SDRs; Region: SDR_c; cd05233
582402008247	NAD(P) binding site [chemical binding]; other site
582402008248	active site
582402008249	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
582402008250	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
582402008251	acyl-activating enzyme (AAE) consensus motif; other site
582402008252	putative AMP binding site [chemical binding]; other site
582402008253	putative active site [active]
582402008254	putative CoA binding site [chemical binding]; other site
582402008255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402008256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402008257	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
582402008258	substrate binding pocket [chemical binding]; other site
582402008259	dimerization interface [polypeptide binding]; other site
582402008260	aldolase II superfamily protein; Provisional; Region: PRK07044
582402008261	intersubunit interface [polypeptide binding]; other site
582402008262	active site
582402008263	Zn2+ binding site [ion binding]; other site
582402008264	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402008265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402008266	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
582402008267	putative effector binding pocket; other site
582402008268	putative dimerization interface [polypeptide binding]; other site
582402008269	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
582402008270	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
582402008271	substrate binding site [chemical binding]; other site
582402008272	catalytic Zn binding site [ion binding]; other site
582402008273	NAD binding site [chemical binding]; other site
582402008274	structural Zn binding site [ion binding]; other site
582402008275	dimer interface [polypeptide binding]; other site
582402008276	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
582402008277	S-formylglutathione hydrolase; Region: PLN02442
582402008278	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
582402008279	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
582402008280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402008281	putative substrate translocation pore; other site
582402008282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402008283	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
582402008284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402008285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402008286	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402008287	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
582402008288	Ligand binding site; other site
582402008289	Putative Catalytic site; other site
582402008290	DXD motif; other site
582402008291	Predicted membrane protein [Function unknown]; Region: COG2246
582402008292	GtrA-like protein; Region: GtrA; pfam04138
582402008293	Putative esterase; Region: Esterase; pfam00756
582402008294	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
582402008295	Response regulator receiver domain; Region: Response_reg; pfam00072
582402008296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008297	active site
582402008298	phosphorylation site [posttranslational modification]
582402008299	intermolecular recognition site; other site
582402008300	dimerization interface [polypeptide binding]; other site
582402008301	Response regulator receiver domain; Region: Response_reg; pfam00072
582402008302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008303	active site
582402008304	phosphorylation site [posttranslational modification]
582402008305	intermolecular recognition site; other site
582402008306	dimerization interface [polypeptide binding]; other site
582402008307	HDOD domain; Region: HDOD; pfam08668
582402008308	Response regulator receiver domain; Region: Response_reg; pfam00072
582402008309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008310	active site
582402008311	phosphorylation site [posttranslational modification]
582402008312	intermolecular recognition site; other site
582402008313	dimerization interface [polypeptide binding]; other site
582402008314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008315	Response regulator receiver domain; Region: Response_reg; pfam00072
582402008316	active site
582402008317	phosphorylation site [posttranslational modification]
582402008318	intermolecular recognition site; other site
582402008319	dimerization interface [polypeptide binding]; other site
582402008320	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582402008321	active site
582402008322	DNA binding site [nucleotide binding]
582402008323	Int/Topo IB signature motif; other site
582402008324	Helix-turn-helix domain; Region: HTH_17; cl17695
582402008325	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
582402008326	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
582402008327	catalytic residues [active]
582402008328	catalytic nucleophile [active]
582402008329	Presynaptic Site I dimer interface [polypeptide binding]; other site
582402008330	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
582402008331	Synaptic Flat tetramer interface [polypeptide binding]; other site
582402008332	Synaptic Site I dimer interface [polypeptide binding]; other site
582402008333	DNA binding site [nucleotide binding]
582402008334	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
582402008335	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
582402008336	putative metal binding site [ion binding]; other site
582402008337	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582402008338	HSP70 interaction site [polypeptide binding]; other site
582402008339	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
582402008340	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
582402008341	Walker A/P-loop; other site
582402008342	ATP binding site [chemical binding]; other site
582402008343	Q-loop/lid; other site
582402008344	ABC transporter signature motif; other site
582402008345	Walker B; other site
582402008346	D-loop; other site
582402008347	H-loop/switch region; other site
582402008348	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
582402008349	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
582402008350	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582402008351	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
582402008352	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
582402008353	active site
582402008354	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
582402008355	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
582402008356	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
582402008357	dimer interface [polypeptide binding]; other site
582402008358	active site
582402008359	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
582402008360	active site 2 [active]
582402008361	active site 1 [active]
582402008362	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
582402008363	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
582402008364	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
582402008365	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
582402008366	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402008367	biotin synthase; Region: bioB; TIGR00433
582402008368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402008369	FeS/SAM binding site; other site
582402008370	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
582402008371	YGGT family; Region: YGGT; pfam02325
582402008372	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
582402008373	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
582402008374	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
582402008375	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
582402008376	homodimer interface [polypeptide binding]; other site
582402008377	NADP binding site [chemical binding]; other site
582402008378	substrate binding site [chemical binding]; other site
582402008379	HNH endonuclease; Region: HNH_4; pfam13395
582402008380	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582402008381	active site
582402008382	nucleophile elbow; other site
582402008383	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
582402008384	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
582402008385	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
582402008386	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582402008387	putative active site [active]
582402008388	metal binding site [ion binding]; metal-binding site
582402008389	homodimer binding site [polypeptide binding]; other site
582402008390	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
582402008391	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
582402008392	active site
582402008393	catalytic site [active]
582402008394	substrate binding site [chemical binding]; other site
582402008395	hypothetical protein; Provisional; Region: PRK11770
582402008396	Domain of unknown function (DUF307); Region: DUF307; pfam03733
582402008397	TIR domain; Region: TIR_2; pfam13676
582402008398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402008399	binding surface
582402008400	TPR motif; other site
582402008401	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582402008402	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582402008403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402008404	binding surface
582402008405	TPR motif; other site
582402008406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582402008407	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
582402008408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402008409	Walker A motif; other site
582402008410	ATP binding site [chemical binding]; other site
582402008411	Walker B motif; other site
582402008412	arginine finger; other site
582402008413	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582402008414	phage shock protein A; Region: phageshock_pspA; TIGR02977
582402008415	Phage shock protein B; Region: PspB; cl05946
582402008416	phage shock protein C; Region: phageshock_pspC; TIGR02978
582402008417	PspC domain; Region: PspC; pfam04024
582402008418	Phage shock protein B; Region: PspB; cl05946
582402008419	Uncharacterized conserved protein [Function unknown]; Region: COG4121
582402008420	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
582402008421	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582402008422	flagellar motor protein MotA; Validated; Region: PRK09110
582402008423	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
582402008424	Transglycosylase SLT domain; Region: SLT_2; pfam13406
582402008425	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
582402008426	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582402008427	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582402008428	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
582402008429	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
582402008430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402008431	motif II; other site
582402008432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402008433	binding surface
582402008434	TPR motif; other site
582402008435	TPR repeat; Region: TPR_11; pfam13414
582402008436	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
582402008437	PAS domain S-box; Region: sensory_box; TIGR00229
582402008438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402008439	putative active site [active]
582402008440	heme pocket [chemical binding]; other site
582402008441	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582402008442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402008443	putative active site [active]
582402008444	heme pocket [chemical binding]; other site
582402008445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402008446	dimer interface [polypeptide binding]; other site
582402008447	phosphorylation site [posttranslational modification]
582402008448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402008449	ATP binding site [chemical binding]; other site
582402008450	Mg2+ binding site [ion binding]; other site
582402008451	G-X-G motif; other site
582402008452	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582402008453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008454	active site
582402008455	phosphorylation site [posttranslational modification]
582402008456	intermolecular recognition site; other site
582402008457	dimerization interface [polypeptide binding]; other site
582402008458	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
582402008459	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
582402008460	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
582402008461	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
582402008462	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
582402008463	ligand binding site [chemical binding]; other site
582402008464	homodimer interface [polypeptide binding]; other site
582402008465	NAD(P) binding site [chemical binding]; other site
582402008466	trimer interface B [polypeptide binding]; other site
582402008467	trimer interface A [polypeptide binding]; other site
582402008468	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
582402008469	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
582402008470	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582402008471	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
582402008472	Zn binding site [ion binding]; other site
582402008473	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582402008474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008475	active site
582402008476	phosphorylation site [posttranslational modification]
582402008477	intermolecular recognition site; other site
582402008478	dimerization interface [polypeptide binding]; other site
582402008479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402008480	Walker A motif; other site
582402008481	ATP binding site [chemical binding]; other site
582402008482	Walker B motif; other site
582402008483	arginine finger; other site
582402008484	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582402008485	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
582402008486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402008487	Walker A/P-loop; other site
582402008488	ATP binding site [chemical binding]; other site
582402008489	Q-loop/lid; other site
582402008490	ABC transporter signature motif; other site
582402008491	Walker B; other site
582402008492	D-loop; other site
582402008493	H-loop/switch region; other site
582402008494	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
582402008495	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
582402008496	Isochorismatase family; Region: Isochorismatase; pfam00857
582402008497	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
582402008498	catalytic triad [active]
582402008499	conserved cis-peptide bond; other site
582402008500	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
582402008501	COQ9; Region: COQ9; pfam08511
582402008502	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402008503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402008504	non-specific DNA binding site [nucleotide binding]; other site
582402008505	salt bridge; other site
582402008506	sequence-specific DNA binding site [nucleotide binding]; other site
582402008507	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
582402008508	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402008509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582402008510	Coenzyme A binding pocket [chemical binding]; other site
582402008511	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
582402008512	ATP-grasp domain; Region: ATP-grasp; pfam02222
582402008513	AIR carboxylase; Region: AIRC; pfam00731
582402008514	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402008515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402008516	metal binding site [ion binding]; metal-binding site
582402008517	active site
582402008518	I-site; other site
582402008519	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
582402008520	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
582402008521	RNAase interaction site [polypeptide binding]; other site
582402008522	Protein of unknown function (DUF465); Region: DUF465; cl01070
582402008523	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
582402008524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402008525	NAD(P) binding site [chemical binding]; other site
582402008526	active site
582402008527	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
582402008528	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
582402008529	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
582402008530	NAD(P) binding site [chemical binding]; other site
582402008531	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
582402008532	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
582402008533	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
582402008534	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
582402008535	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582402008536	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402008537	Walker A/P-loop; other site
582402008538	ATP binding site [chemical binding]; other site
582402008539	Q-loop/lid; other site
582402008540	ABC transporter signature motif; other site
582402008541	Walker B; other site
582402008542	D-loop; other site
582402008543	H-loop/switch region; other site
582402008544	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582402008545	Beta-lactamase; Region: Beta-lactamase; pfam00144
582402008546	DinB family; Region: DinB; cl17821
582402008547	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582402008548	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
582402008549	active site
582402008550	dimerization interface [polypeptide binding]; other site
582402008551	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
582402008552	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
582402008553	thiamine phosphate binding site [chemical binding]; other site
582402008554	active site
582402008555	pyrophosphate binding site [ion binding]; other site
582402008556	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
582402008557	catalytic residue [active]
582402008558	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
582402008559	Phosphoglycerate kinase; Region: PGK; pfam00162
582402008560	substrate binding site [chemical binding]; other site
582402008561	hinge regions; other site
582402008562	ADP binding site [chemical binding]; other site
582402008563	catalytic site [active]
582402008564	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
582402008565	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
582402008566	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
582402008567	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
582402008568	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
582402008569	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
582402008570	TPP-binding site [chemical binding]; other site
582402008571	dimer interface [polypeptide binding]; other site
582402008572	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582402008573	PYR/PP interface [polypeptide binding]; other site
582402008574	dimer interface [polypeptide binding]; other site
582402008575	TPP binding site [chemical binding]; other site
582402008576	Cell division protein ZapA; Region: ZapA; pfam05164
582402008577	Predicted flavoproteins [General function prediction only]; Region: COG2081
582402008578	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582402008579	Response regulator receiver domain; Region: Response_reg; pfam00072
582402008580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008581	active site
582402008582	phosphorylation site [posttranslational modification]
582402008583	intermolecular recognition site; other site
582402008584	dimerization interface [polypeptide binding]; other site
582402008585	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
582402008586	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402008587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402008588	sequence-specific DNA binding site [nucleotide binding]; other site
582402008589	salt bridge; other site
582402008590	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582402008591	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
582402008592	active site
582402008593	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
582402008594	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582402008595	SCP-2 sterol transfer family; Region: SCP2; pfam02036
582402008596	Predicted methyltransferase [General function prediction only]; Region: COG4798
582402008597	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582402008598	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
582402008599	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
582402008600	putative dimer interface [polypeptide binding]; other site
582402008601	Rhomboid family; Region: Rhomboid; pfam01694
582402008602	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
582402008603	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582402008604	C-terminal domain interface [polypeptide binding]; other site
582402008605	GSH binding site (G-site) [chemical binding]; other site
582402008606	dimer interface [polypeptide binding]; other site
582402008607	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
582402008608	N-terminal domain interface [polypeptide binding]; other site
582402008609	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
582402008610	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402008611	putative ADP-binding pocket [chemical binding]; other site
582402008612	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
582402008613	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582402008614	dimerization interface [polypeptide binding]; other site
582402008615	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582402008616	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582402008617	dimer interface [polypeptide binding]; other site
582402008618	putative CheW interface [polypeptide binding]; other site
582402008619	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
582402008620	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
582402008621	G1 box; other site
582402008622	putative GEF interaction site [polypeptide binding]; other site
582402008623	GTP/Mg2+ binding site [chemical binding]; other site
582402008624	Switch I region; other site
582402008625	G2 box; other site
582402008626	G3 box; other site
582402008627	Switch II region; other site
582402008628	G4 box; other site
582402008629	G5 box; other site
582402008630	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
582402008631	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
582402008632	Domain of unknown function (DUF1287); Region: DUF1287; pfam06940
582402008633	Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609
582402008634	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
582402008635	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582402008636	classical (c) SDRs; Region: SDR_c; cd05233
582402008637	NAD(P) binding site [chemical binding]; other site
582402008638	active site
582402008639	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
582402008640	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
582402008641	Peptidase family M48; Region: Peptidase_M48; cl12018
582402008642	NusB family; Region: NusB; pfam01029
582402008643	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
582402008644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402008645	S-adenosylmethionine binding site [chemical binding]; other site
582402008646	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
582402008647	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
582402008648	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
582402008649	substrate binding site [chemical binding]; other site
582402008650	hexamer interface [polypeptide binding]; other site
582402008651	metal binding site [ion binding]; metal-binding site
582402008652	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
582402008653	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
582402008654	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
582402008655	NAD(P) binding site [chemical binding]; other site
582402008656	homodimer interface [polypeptide binding]; other site
582402008657	substrate binding site [chemical binding]; other site
582402008658	active site
582402008659	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
582402008660	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
582402008661	purine monophosphate binding site [chemical binding]; other site
582402008662	dimer interface [polypeptide binding]; other site
582402008663	putative catalytic residues [active]
582402008664	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
582402008665	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
582402008666	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582402008667	metal ion-dependent adhesion site (MIDAS); other site
582402008668	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
582402008669	active site residue [active]
582402008670	argininosuccinate synthase; Provisional; Region: PRK13820
582402008671	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
582402008672	ANP binding site [chemical binding]; other site
582402008673	Substrate Binding Site II [chemical binding]; other site
582402008674	Substrate Binding Site I [chemical binding]; other site
582402008675	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
582402008676	dimer interface [polypeptide binding]; other site
582402008677	substrate binding site [chemical binding]; other site
582402008678	metal binding sites [ion binding]; metal-binding site
582402008679	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
582402008680	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
582402008681	active site clefts [active]
582402008682	zinc binding site [ion binding]; other site
582402008683	dimer interface [polypeptide binding]; other site
582402008684	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582402008685	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582402008686	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
582402008687	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
582402008688	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
582402008689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402008690	active site
582402008691	phosphorylation site [posttranslational modification]
582402008692	intermolecular recognition site; other site
582402008693	dimerization interface [polypeptide binding]; other site
582402008694	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
582402008695	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402008696	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402008697	phosphorylation site [posttranslational modification]
582402008698	dimer interface [polypeptide binding]; other site
582402008699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402008700	ATP binding site [chemical binding]; other site
582402008701	Mg2+ binding site [ion binding]; other site
582402008702	G-X-G motif; other site
582402008703	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
582402008704	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
582402008705	Cu(I) binding site [ion binding]; other site
582402008706	Protein of unknown function DUF45; Region: DUF45; pfam01863
582402008707	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
582402008708	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
582402008709	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
582402008710	putative catalytic site [active]
582402008711	putative metal binding site [ion binding]; other site
582402008712	putative phosphate binding site [ion binding]; other site
582402008713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402008714	binding surface
582402008715	Tetratricopeptide repeat; Region: TPR_16; pfam13432
582402008716	TPR motif; other site
582402008717	TPR repeat; Region: TPR_11; pfam13414
582402008718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402008719	binding surface
582402008720	TPR motif; other site
582402008721	Tetratricopeptide repeat; Region: TPR_16; pfam13432
582402008722	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
582402008723	CoA binding domain; Region: CoA_binding; cl17356
582402008724	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582402008725	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008726	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402008727	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582402008728	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
582402008729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402008730	Mg2+ binding site [ion binding]; other site
582402008731	G-X-G motif; other site
582402008732	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
582402008733	anchoring element; other site
582402008734	dimer interface [polypeptide binding]; other site
582402008735	ATP binding site [chemical binding]; other site
582402008736	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
582402008737	active site
582402008738	putative metal-binding site [ion binding]; other site
582402008739	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
582402008740	recombination protein F; Reviewed; Region: recF; PRK00064
582402008741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402008742	Walker A/P-loop; other site
582402008743	ATP binding site [chemical binding]; other site
582402008744	Q-loop/lid; other site
582402008745	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582402008746	ABC transporter signature motif; other site
582402008747	Walker B; other site
582402008748	D-loop; other site
582402008749	H-loop/switch region; other site
582402008750	DNA polymerase III subunit beta; Validated; Region: PRK05643
582402008751	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
582402008752	putative DNA binding surface [nucleotide binding]; other site
582402008753	dimer interface [polypeptide binding]; other site
582402008754	beta-clamp/clamp loader binding surface; other site
582402008755	beta-clamp/translesion DNA polymerase binding surface; other site
582402008756	DnaA N-terminal domain; Region: DnaA_N; pfam11638
582402008757	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
582402008758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402008759	Walker A motif; other site
582402008760	ATP binding site [chemical binding]; other site
582402008761	Walker B motif; other site
582402008762	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
582402008763	DnaA box-binding interface [nucleotide binding]; other site
582402008764	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
582402008765	enoyl-CoA hydratase; Provisional; Region: PRK05862
582402008766	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582402008767	substrate binding site [chemical binding]; other site
582402008768	oxyanion hole (OAH) forming residues; other site
582402008769	trimer interface [polypeptide binding]; other site
582402008770	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
582402008771	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
582402008772	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
582402008773	DNA binding site [nucleotide binding]
582402008774	catalytic residue [active]
582402008775	H2TH interface [polypeptide binding]; other site
582402008776	putative catalytic residues [active]
582402008777	turnover-facilitating residue; other site
582402008778	intercalation triad [nucleotide binding]; other site
582402008779	8OG recognition residue [nucleotide binding]; other site
582402008780	putative reading head residues; other site
582402008781	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
582402008782	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
582402008783	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
582402008784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402008785	S-adenosylmethionine binding site [chemical binding]; other site
582402008786	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
582402008787	ABC1 family; Region: ABC1; cl17513
582402008788	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
582402008789	Flavoprotein; Region: Flavoprotein; pfam02441
582402008790	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
582402008791	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
582402008792	trimer interface [polypeptide binding]; other site
582402008793	active site
582402008794	Protein of unknown function DUF91; Region: DUF91; cl00709
582402008795	PIF1-like helicase; Region: PIF1; pfam05970
582402008796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402008797	Walker A motif; other site
582402008798	ATP binding site [chemical binding]; other site
582402008799	Walker B motif; other site
582402008800	arginine finger; other site
582402008801	Family description; Region: UvrD_C_2; pfam13538
582402008802	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
582402008803	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
582402008804	ATP binding site [chemical binding]; other site
582402008805	substrate interface [chemical binding]; other site
582402008806	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582402008807	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
582402008808	TAP-like protein; Region: Abhydrolase_4; pfam08386
582402008809	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
582402008810	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
582402008811	dimerization interface [polypeptide binding]; other site
582402008812	ligand binding site [chemical binding]; other site
582402008813	NADP binding site [chemical binding]; other site
582402008814	catalytic site [active]
582402008815	Bacterial SH3 domain; Region: SH3_4; pfam06347
582402008816	Bacterial SH3 domain; Region: SH3_4; pfam06347
582402008817	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
582402008818	active site 1 [active]
582402008819	dimer interface [polypeptide binding]; other site
582402008820	active site 2 [active]
582402008821	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
582402008822	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582402008823	dimer interface [polypeptide binding]; other site
582402008824	active site
582402008825	S-adenosylmethionine synthetase; Validated; Region: PRK05250
582402008826	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
582402008827	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
582402008828	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
582402008829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402008830	S-adenosylmethionine binding site [chemical binding]; other site
582402008831	ribosome maturation protein RimP; Reviewed; Region: PRK00092
582402008832	Sm and related proteins; Region: Sm_like; cl00259
582402008833	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
582402008834	putative oligomer interface [polypeptide binding]; other site
582402008835	putative RNA binding site [nucleotide binding]; other site
582402008836	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
582402008837	NusA N-terminal domain; Region: NusA_N; pfam08529
582402008838	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
582402008839	RNA binding site [nucleotide binding]; other site
582402008840	homodimer interface [polypeptide binding]; other site
582402008841	NusA-like KH domain; Region: KH_5; pfam13184
582402008842	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
582402008843	G-X-X-G motif; other site
582402008844	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
582402008845	Protein of unknown function (DUF448); Region: DUF448; pfam04296
582402008846	putative RNA binding cleft [nucleotide binding]; other site
582402008847	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
582402008848	translation initiation factor IF-2; Validated; Region: infB; PRK05306
582402008849	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
582402008850	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
582402008851	G1 box; other site
582402008852	putative GEF interaction site [polypeptide binding]; other site
582402008853	GTP/Mg2+ binding site [chemical binding]; other site
582402008854	Switch I region; other site
582402008855	G2 box; other site
582402008856	G3 box; other site
582402008857	Switch II region; other site
582402008858	G4 box; other site
582402008859	G5 box; other site
582402008860	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
582402008861	Translation-initiation factor 2; Region: IF-2; pfam11987
582402008862	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
582402008863	YcxB-like protein; Region: YcxB; pfam14317
582402008864	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
582402008865	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
582402008866	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
582402008867	RNA binding site [nucleotide binding]; other site
582402008868	active site
582402008869	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
582402008870	16S/18S rRNA binding site [nucleotide binding]; other site
582402008871	S13e-L30e interaction site [polypeptide binding]; other site
582402008872	25S rRNA binding site [nucleotide binding]; other site
582402008873	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
582402008874	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
582402008875	RNase E interface [polypeptide binding]; other site
582402008876	trimer interface [polypeptide binding]; other site
582402008877	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
582402008878	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
582402008879	RNase E interface [polypeptide binding]; other site
582402008880	trimer interface [polypeptide binding]; other site
582402008881	active site
582402008882	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
582402008883	putative nucleic acid binding region [nucleotide binding]; other site
582402008884	G-X-X-G motif; other site
582402008885	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
582402008886	RNA binding site [nucleotide binding]; other site
582402008887	domain interface; other site
582402008888	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582402008889	GIY-YIG motif/motif A; other site
582402008890	putative active site [active]
582402008891	putative metal binding site [ion binding]; other site
582402008892	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402008893	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
582402008894	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
582402008895	AAA domain; Region: AAA_18; pfam13238
582402008896	ATP-binding site [chemical binding]; other site
582402008897	Sugar specificity; other site
582402008898	Pyrimidine base specificity; other site
582402008899	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
582402008900	trimer interface [polypeptide binding]; other site
582402008901	active site
582402008902	substrate binding site [chemical binding]; other site
582402008903	CoA binding site [chemical binding]; other site
582402008904	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582402008905	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
582402008906	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
582402008907	NAD binding site [chemical binding]; other site
582402008908	homotetramer interface [polypeptide binding]; other site
582402008909	homodimer interface [polypeptide binding]; other site
582402008910	substrate binding site [chemical binding]; other site
582402008911	active site
582402008912	GntP family permease; Region: GntP_permease; pfam02447
582402008913	fructuronate transporter; Provisional; Region: PRK10034; cl15264
582402008914	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
582402008915	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
582402008916	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
582402008917	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
582402008918	Strictosidine synthase; Region: Str_synth; pfam03088
582402008919	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
582402008920	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
582402008921	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402008922	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402008923	DNA binding site [nucleotide binding]
582402008924	domain linker motif; other site
582402008925	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
582402008926	putative ligand binding site [chemical binding]; other site
582402008927	putative dimerization interface [polypeptide binding]; other site
582402008928	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582402008929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402008930	sequence-specific DNA binding site [nucleotide binding]; other site
582402008931	salt bridge; other site
582402008932	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
582402008933	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
582402008934	putative active site [active]
582402008935	catalytic triad [active]
582402008936	putative dimer interface [polypeptide binding]; other site
582402008937	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
582402008938	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582402008939	Transporter associated domain; Region: CorC_HlyC; smart01091
582402008940	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
582402008941	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
582402008942	PhoH-like protein; Region: PhoH; pfam02562
582402008943	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
582402008944	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582402008945	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402008946	FeS/SAM binding site; other site
582402008947	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582402008948	metal binding site 2 [ion binding]; metal-binding site
582402008949	putative DNA binding helix; other site
582402008950	metal binding site 1 [ion binding]; metal-binding site
582402008951	dimer interface [polypeptide binding]; other site
582402008952	structural Zn2+ binding site [ion binding]; other site
582402008953	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582402008954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582402008955	Coenzyme A binding pocket [chemical binding]; other site
582402008956	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
582402008957	Glycoprotease family; Region: Peptidase_M22; pfam00814
582402008958	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
582402008959	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
582402008960	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582402008961	Ligand Binding Site [chemical binding]; other site
582402008962	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
582402008963	Protein of unknown function (DUF461); Region: DUF461; pfam04314
582402008964	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
582402008965	active site
582402008966	HIGH motif; other site
582402008967	dimer interface [polypeptide binding]; other site
582402008968	KMSKS motif; other site
582402008969	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582402008970	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
582402008971	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
582402008972	PII uridylyl-transferase; Provisional; Region: PRK05092
582402008973	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582402008974	metal binding triad; other site
582402008975	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582402008976	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582402008977	Zn2+ binding site [ion binding]; other site
582402008978	Mg2+ binding site [ion binding]; other site
582402008979	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
582402008980	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
582402008981	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
582402008982	MutS domain I; Region: MutS_I; pfam01624
582402008983	MutS domain II; Region: MutS_II; pfam05188
582402008984	MutS domain III; Region: MutS_III; pfam05192
582402008985	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
582402008986	Walker A/P-loop; other site
582402008987	ATP binding site [chemical binding]; other site
582402008988	Q-loop/lid; other site
582402008989	ABC transporter signature motif; other site
582402008990	Walker B; other site
582402008991	D-loop; other site
582402008992	H-loop/switch region; other site
582402008993	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
582402008994	Malic enzyme, N-terminal domain; Region: malic; pfam00390
582402008995	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
582402008996	putative NAD(P) binding site [chemical binding]; other site
582402008997	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
582402008998	muropeptide transporter; Reviewed; Region: ampG; PRK11902
582402008999	AmpG-like permease; Region: 2A0125; TIGR00901
582402009000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402009001	dimer interface [polypeptide binding]; other site
582402009002	phosphorylation site [posttranslational modification]
582402009003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402009004	ATP binding site [chemical binding]; other site
582402009005	Mg2+ binding site [ion binding]; other site
582402009006	G-X-G motif; other site
582402009007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402009008	Response regulator receiver domain; Region: Response_reg; pfam00072
582402009009	active site
582402009010	phosphorylation site [posttranslational modification]
582402009011	intermolecular recognition site; other site
582402009012	dimerization interface [polypeptide binding]; other site
582402009013	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
582402009014	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
582402009015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402009016	Walker A motif; other site
582402009017	ATP binding site [chemical binding]; other site
582402009018	Walker B motif; other site
582402009019	arginine finger; other site
582402009020	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
582402009021	glutathione synthetase; Provisional; Region: PRK05246
582402009022	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
582402009023	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
582402009024	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
582402009025	BON domain; Region: BON; pfam04972
582402009026	BON domain; Region: BON; pfam04972
582402009027	hypothetical protein; Reviewed; Region: PRK12497
582402009028	Predicted methyltransferases [General function prediction only]; Region: COG0313
582402009029	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
582402009030	putative SAM binding site [chemical binding]; other site
582402009031	putative homodimer interface [polypeptide binding]; other site
582402009032	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582402009033	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
582402009034	putative ligand binding site [chemical binding]; other site
582402009035	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
582402009036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582402009037	FeS/SAM binding site; other site
582402009038	HemN C-terminal domain; Region: HemN_C; pfam06969
582402009039	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
582402009040	active site
582402009041	dimerization interface [polypeptide binding]; other site
582402009042	Predicted transcriptional regulator [Transcription]; Region: COG3655
582402009043	non-specific DNA binding site [nucleotide binding]; other site
582402009044	salt bridge; other site
582402009045	sequence-specific DNA binding site [nucleotide binding]; other site
582402009046	ribonuclease PH; Reviewed; Region: rph; PRK00173
582402009047	Ribonuclease PH; Region: RNase_PH_bact; cd11362
582402009048	hexamer interface [polypeptide binding]; other site
582402009049	active site
582402009050	heat shock protein GrpE; Provisional; Region: PRK14140
582402009051	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
582402009052	dimer interface [polypeptide binding]; other site
582402009053	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
582402009054	Predicted transcriptional regulators [Transcription]; Region: COG1733
582402009055	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
582402009056	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
582402009057	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
582402009058	substrate binding site [chemical binding]; other site
582402009059	ATP binding site [chemical binding]; other site
582402009060	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
582402009061	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582402009062	minor groove reading motif; other site
582402009063	helix-hairpin-helix signature motif; other site
582402009064	substrate binding pocket [chemical binding]; other site
582402009065	active site
582402009066	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
582402009067	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
582402009068	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
582402009069	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582402009070	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
582402009071	dimer interface [polypeptide binding]; other site
582402009072	active site
582402009073	metal binding site [ion binding]; metal-binding site
582402009074	glutathione binding site [chemical binding]; other site
582402009075	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
582402009076	active site
582402009077	dihydrodipicolinate reductase; Provisional; Region: PRK00048
582402009078	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
582402009079	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
582402009080	chaperone protein DnaJ; Provisional; Region: PRK10767
582402009081	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582402009082	HSP70 interaction site [polypeptide binding]; other site
582402009083	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
582402009084	substrate binding site [polypeptide binding]; other site
582402009085	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
582402009086	Zn binding sites [ion binding]; other site
582402009087	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
582402009088	dimer interface [polypeptide binding]; other site
582402009089	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
582402009090	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
582402009091	nucleotide binding site [chemical binding]; other site
582402009092	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
582402009093	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
582402009094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582402009095	Walker A motif; other site
582402009096	ATP binding site [chemical binding]; other site
582402009097	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
582402009098	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
582402009099	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
582402009100	active site
582402009101	HslU subunit interaction site [polypeptide binding]; other site
582402009102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582402009103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582402009104	metal binding site [ion binding]; metal-binding site
582402009105	active site
582402009106	I-site; other site
582402009107	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582402009108	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
582402009109	putative active site pocket [active]
582402009110	4-fold oligomerization interface [polypeptide binding]; other site
582402009111	metal binding residues [ion binding]; metal-binding site
582402009112	3-fold/trimer interface [polypeptide binding]; other site
582402009113	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
582402009114	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
582402009115	putative active site [active]
582402009116	oxyanion strand; other site
582402009117	catalytic triad [active]
582402009118	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
582402009119	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
582402009120	catalytic residues [active]
582402009121	Pirin-related protein [General function prediction only]; Region: COG1741
582402009122	Pirin; Region: Pirin; pfam02678
582402009123	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
582402009124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582402009125	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582402009126	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
582402009127	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
582402009128	substrate binding site [chemical binding]; other site
582402009129	glutamase interaction surface [polypeptide binding]; other site
582402009130	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
582402009131	metal binding site [ion binding]; metal-binding site
582402009132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
582402009133	Smr domain; Region: Smr; pfam01713
582402009134	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
582402009135	MltA specific insert domain; Region: MltA; smart00925
582402009136	3D domain; Region: 3D; pfam06725
582402009137	Tim44-like domain; Region: Tim44; pfam04280
582402009138	Preprotein translocase subunit SecB; Region: SecB; pfam02556
582402009139	SecA binding site; other site
582402009140	Preprotein binding site; other site
582402009141	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
582402009142	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
582402009143	active site
582402009144	catalytic site [active]
582402009145	substrate binding site [chemical binding]; other site
582402009146	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
582402009147	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
582402009148	CoA-binding site [chemical binding]; other site
582402009149	ATP-binding [chemical binding]; other site
582402009150	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
582402009151	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
582402009152	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
582402009153	shikimate binding site; other site
582402009154	NAD(P) binding site [chemical binding]; other site
582402009155	Maf-like protein; Region: Maf; pfam02545
582402009156	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582402009157	active site
582402009158	dimer interface [polypeptide binding]; other site
582402009159	PEP synthetase regulatory protein; Provisional; Region: PRK05339
582402009160	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
582402009161	substrate binding site [chemical binding]; other site
582402009162	active site
582402009163	Ferrochelatase; Region: Ferrochelatase; pfam00762
582402009164	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
582402009165	C-terminal domain interface [polypeptide binding]; other site
582402009166	active site
582402009167	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
582402009168	active site
582402009169	N-terminal domain interface [polypeptide binding]; other site
582402009170	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
582402009171	transcription termination factor Rho; Provisional; Region: rho; PRK09376
582402009172	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
582402009173	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
582402009174	RNA binding site [nucleotide binding]; other site
582402009175	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
582402009176	multimer interface [polypeptide binding]; other site
582402009177	Walker A motif; other site
582402009178	ATP binding site [chemical binding]; other site
582402009179	Walker B motif; other site
582402009180	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
582402009181	ArsC family; Region: ArsC; pfam03960
582402009182	putative catalytic residues [active]
582402009183	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
582402009184	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
582402009185	trmE is a tRNA modification GTPase; Region: trmE; cd04164
582402009186	G1 box; other site
582402009187	GTP/Mg2+ binding site [chemical binding]; other site
582402009188	Switch I region; other site
582402009189	G2 box; other site
582402009190	Switch II region; other site
582402009191	G3 box; other site
582402009192	G4 box; other site
582402009193	G5 box; other site
582402009194	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
582402009195	Methyltransferase domain; Region: Methyltransf_24; pfam13578
582402009196	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
582402009197	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
582402009198	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
582402009199	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402009200	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
582402009201	Probable Catalytic site; other site
582402009202	metal-binding site
582402009203	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402009204	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582402009205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402009206	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
582402009207	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
582402009208	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
582402009209	NAD binding site [chemical binding]; other site
582402009210	substrate binding site [chemical binding]; other site
582402009211	homodimer interface [polypeptide binding]; other site
582402009212	active site
582402009213	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
582402009214	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
582402009215	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
582402009216	substrate binding site; other site
582402009217	tetramer interface; other site
582402009218	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
582402009219	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
582402009220	Probable Catalytic site; other site
582402009221	metal-binding site
582402009222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582402009223	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582402009224	NAD(P) binding site [chemical binding]; other site
582402009225	active site
582402009226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402009227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402009228	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582402009229	dimerization interface [polypeptide binding]; other site
582402009230	Peptidase family M48; Region: Peptidase_M48; cl12018
582402009231	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402009232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402009233	LysR substrate binding domain; Region: LysR_substrate; pfam03466
582402009234	dimerization interface [polypeptide binding]; other site
582402009235	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
582402009236	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402009237	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582402009238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582402009239	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582402009240	dimerization interface [polypeptide binding]; other site
582402009241	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582402009242	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
582402009243	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
582402009244	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
582402009245	Replication initiator protein A; Region: RPA; pfam10134
582402009246	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582402009247	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582402009248	P-loop; other site
582402009249	Magnesium ion binding site [ion binding]; other site
582402009250	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
582402009251	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
582402009252	Protein of unknown function (DUF805); Region: DUF805; pfam05656
582402009253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402009254	binding surface
582402009255	TPR motif; other site
582402009256	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582402009257	TPR repeat; Region: TPR_11; pfam13414
582402009258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582402009259	TPR motif; other site
582402009260	binding surface
582402009261	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
582402009262	TPR repeat; Region: TPR_11; pfam13414
582402009263	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582402009264	Sel1-like repeats; Region: SEL1; smart00671
582402009265	Sel1-like repeats; Region: SEL1; smart00671
582402009266	HipA N-terminal domain; Region: Couple_hipA; pfam13657
582402009267	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
582402009268	HipA-like N-terminal domain; Region: HipA_N; pfam07805
582402009269	HipA-like C-terminal domain; Region: HipA_C; pfam07804
582402009270	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582402009271	non-specific DNA binding site [nucleotide binding]; other site
582402009272	salt bridge; other site
582402009273	sequence-specific DNA binding site [nucleotide binding]; other site
582402009274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582402009275	catalytic core [active]
582402009276	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
582402009277	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
582402009278	Ligand binding site; other site
582402009279	oligomer interface; other site
582402009280	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
582402009281	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582402009282	dimer interface [polypeptide binding]; other site
582402009283	active site
582402009284	CoA binding pocket [chemical binding]; other site
582402009285	Response regulator receiver domain; Region: Response_reg; pfam00072
582402009286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582402009287	active site
582402009288	phosphorylation site [posttranslational modification]
582402009289	intermolecular recognition site; other site
582402009290	dimerization interface [polypeptide binding]; other site
582402009291	PAS fold; Region: PAS; pfam00989
582402009292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402009293	putative active site [active]
582402009294	heme pocket [chemical binding]; other site
582402009295	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582402009296	PAS fold; Region: PAS_3; pfam08447
582402009297	putative active site [active]
582402009298	heme pocket [chemical binding]; other site
582402009299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582402009300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582402009301	dimer interface [polypeptide binding]; other site
582402009302	phosphorylation site [posttranslational modification]
582402009303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582402009304	ATP binding site [chemical binding]; other site
582402009305	Mg2+ binding site [ion binding]; other site
582402009306	G-X-G motif; other site
582402009307	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
582402009308	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
582402009309	NADP binding site [chemical binding]; other site
582402009310	active site
582402009311	putative substrate binding site [chemical binding]; other site
582402009312	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
582402009313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582402009314	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
582402009315	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
582402009316	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
582402009317	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
582402009318	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
582402009319	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
582402009320	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
582402009321	putative active site [active]
582402009322	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
582402009323	UDP-glucose 4-epimerase; Region: PLN02240
582402009324	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
582402009325	NAD binding site [chemical binding]; other site
582402009326	homodimer interface [polypeptide binding]; other site
582402009327	active site
582402009328	substrate binding site [chemical binding]; other site
582402009329	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
582402009330	active site
582402009331	catalytic residues [active]
582402009332	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582402009333	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582402009334	HlyD family secretion protein; Region: HlyD_3; pfam13437
582402009335	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
582402009336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
582402009337	nucleotide binding site [chemical binding]; other site
582402009338	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
582402009339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582402009340	putative substrate translocation pore; other site
582402009341	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
582402009342	active site
582402009343	Transcriptional regulators [Transcription]; Region: PurR; COG1609
582402009344	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
582402009345	DNA binding site [nucleotide binding]
582402009346	domain linker motif; other site
582402009347	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
582402009348	putative dimerization interface [polypeptide binding]; other site
582402009349	putative ligand binding site [chemical binding]; other site
582402009350	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
582402009351	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402009352	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582402009353	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582402009354	active site
582402009355	Predicted membrane protein [Function unknown]; Region: COG2246
582402009356	GtrA-like protein; Region: GtrA; pfam04138
582402009357	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582402009358	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
582402009359	NAD binding site [chemical binding]; other site
582402009360	putative substrate binding site 2 [chemical binding]; other site
582402009361	putative substrate binding site 1 [chemical binding]; other site
582402009362	active site
582402009363	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402009364	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
582402009365	Ligand binding site; other site
582402009366	Putative Catalytic site; other site
582402009367	DXD motif; other site
582402009368	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584
582402009369	putative active site [active]
582402009370	catalytic site [active]
582402009371	Zeta toxin; Region: Zeta_toxin; pfam06414
582402009372	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
582402009373	active site
582402009374	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
582402009375	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582402009376	motif II; other site
582402009377	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582402009378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582402009379	S-adenosylmethionine binding site [chemical binding]; other site
582402009380	Predicted membrane protein [Function unknown]; Region: COG2246
582402009381	GtrA-like protein; Region: GtrA; pfam04138
582402009382	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582402009383	active site
582402009384	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582402009385	active site
582402009386	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
582402009387	Uncharacterized conserved protein [Function unknown]; Region: COG3347
582402009388	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
582402009389	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582402009390	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
582402009391	Probable Catalytic site; other site
582402009392	metal-binding site
582402009393	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582402009394	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
582402009395	Probable Catalytic site; other site
582402009396	metal-binding site
582402009397	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
582402009398	ABC-2 type transporter; Region: ABC2_membrane; cl17235
582402009399	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
582402009400	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
582402009401	Walker A/P-loop; other site
582402009402	ATP binding site [chemical binding]; other site
582402009403	Q-loop/lid; other site
582402009404	ABC transporter signature motif; other site
582402009405	Walker B; other site
582402009406	D-loop; other site
582402009407	H-loop/switch region; other site
582402009408	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
582402009409	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884