-- dump date   	20140619_115133
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
608538000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
608538000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000003	Walker A motif; other site
608538000004	ATP binding site [chemical binding]; other site
608538000005	Walker B motif; other site
608538000006	arginine finger; other site
608538000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
608538000008	DnaA box-binding interface [nucleotide binding]; other site
608538000009	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
608538000010	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
608538000011	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
608538000012	classical (c) SDRs; Region: SDR_c; cd05233
608538000013	NAD(P) binding site [chemical binding]; other site
608538000014	active site
608538000015	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
608538000016	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
608538000017	putative active site [active]
608538000018	metal binding site [ion binding]; metal-binding site
608538000019	homodimer binding site [polypeptide binding]; other site
608538000020	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
608538000021	Flavoprotein; Region: Flavoprotein; pfam02441
608538000022	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
608538000023	Na binding site [ion binding]; other site
608538000024	putative glycosylation site [posttranslational modification]; other site
608538000025	putative glycosylation site [posttranslational modification]; other site
608538000026	aspartate aminotransferase; Provisional; Region: PRK05764
608538000027	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538000028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538000029	homodimer interface [polypeptide binding]; other site
608538000030	catalytic residue [active]
608538000031	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
608538000032	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
608538000033	NAD binding site [chemical binding]; other site
608538000034	homotetramer interface [polypeptide binding]; other site
608538000035	homodimer interface [polypeptide binding]; other site
608538000036	substrate binding site [chemical binding]; other site
608538000037	active site
608538000038	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
608538000039	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
608538000040	putative active site; other site
608538000041	catalytic residue [active]
608538000042	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
608538000043	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
608538000044	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
608538000045	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
608538000046	active site
608538000047	substrate binding site [chemical binding]; other site
608538000048	metal binding site [ion binding]; metal-binding site
608538000049	Protein of unknown function DUF45; Region: DUF45; pfam01863
608538000050	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
608538000051	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
608538000052	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538000053	ATP binding site [chemical binding]; other site
608538000054	putative Mg++ binding site [ion binding]; other site
608538000055	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
608538000056	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538000057	active site
608538000058	NTP binding site [chemical binding]; other site
608538000059	metal binding triad [ion binding]; metal-binding site
608538000060	antibiotic binding site [chemical binding]; other site
608538000061	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
608538000062	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
608538000063	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
608538000064	HsdM N-terminal domain; Region: HsdM_N; pfam12161
608538000065	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
608538000066	Methyltransferase domain; Region: Methyltransf_26; pfam13659
608538000067	MoxR-like ATPases [General function prediction only]; Region: COG0714
608538000068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000069	Walker A motif; other site
608538000070	ATP binding site [chemical binding]; other site
608538000071	Walker B motif; other site
608538000072	arginine finger; other site
608538000073	ribosome maturation protein RimP; Reviewed; Region: PRK00092
608538000074	Sm and related proteins; Region: Sm_like; cl00259
608538000075	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
608538000076	putative oligomer interface [polypeptide binding]; other site
608538000077	putative RNA binding site [nucleotide binding]; other site
608538000078	transcription termination factor NusA; Region: NusA; TIGR01953
608538000079	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
608538000080	RNA binding site [nucleotide binding]; other site
608538000081	homodimer interface [polypeptide binding]; other site
608538000082	NusA-like KH domain; Region: KH_5; pfam13184
608538000083	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
608538000084	G-X-X-G motif; other site
608538000085	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
608538000086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000087	S-adenosylmethionine binding site [chemical binding]; other site
608538000088	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
608538000089	ATP cone domain; Region: ATP-cone; pfam03477
608538000090	Class I ribonucleotide reductase; Region: RNR_I; cd01679
608538000091	active site
608538000092	dimer interface [polypeptide binding]; other site
608538000093	catalytic residues [active]
608538000094	effector binding site; other site
608538000095	R2 peptide binding site; other site
608538000096	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
608538000097	dimer interface [polypeptide binding]; other site
608538000098	putative radical transfer pathway; other site
608538000099	diiron center [ion binding]; other site
608538000100	tyrosyl radical; other site
608538000101	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
608538000102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000103	putative substrate translocation pore; other site
608538000104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000105	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
608538000106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000107	putative substrate translocation pore; other site
608538000108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000109	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
608538000110	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538000111	FlxA-like protein; Region: FlxA; pfam14282
608538000112	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538000113	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
608538000114	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538000115	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
608538000116	Outer membrane efflux protein; Region: OEP; pfam02321
608538000117	Outer membrane efflux protein; Region: OEP; pfam02321
608538000118	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538000119	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538000120	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538000121	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
608538000122	Protein export membrane protein; Region: SecD_SecF; cl14618
608538000123	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
608538000124	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538000125	minor groove reading motif; other site
608538000126	helix-hairpin-helix signature motif; other site
608538000127	substrate binding pocket [chemical binding]; other site
608538000128	active site
608538000129	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
608538000130	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538000131	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
608538000132	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
608538000133	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
608538000134	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
608538000135	putative catalytic cysteine [active]
608538000136	glycogen branching enzyme; Provisional; Region: PRK12313
608538000137	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
608538000138	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
608538000139	active site
608538000140	catalytic site [active]
608538000141	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
608538000142	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
608538000143	MutS domain I; Region: MutS_I; pfam01624
608538000144	MutS domain II; Region: MutS_II; pfam05188
608538000145	MutS domain III; Region: MutS_III; pfam05192
608538000146	MutS domain V; Region: MutS_V; pfam00488
608538000147	Walker A/P-loop; other site
608538000148	ATP binding site [chemical binding]; other site
608538000149	Q-loop/lid; other site
608538000150	ABC transporter signature motif; other site
608538000151	Walker B; other site
608538000152	D-loop; other site
608538000153	H-loop/switch region; other site
608538000154	phosphodiesterase; Provisional; Region: PRK12704
608538000155	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
608538000156	Zn2+ binding site [ion binding]; other site
608538000157	Mg2+ binding site [ion binding]; other site
608538000158	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
608538000159	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
608538000160	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
608538000161	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
608538000162	putative tRNA-binding site [nucleotide binding]; other site
608538000163	B3/4 domain; Region: B3_4; pfam03483
608538000164	tRNA synthetase B5 domain; Region: B5; smart00874
608538000165	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
608538000166	dimer interface [polypeptide binding]; other site
608538000167	motif 1; other site
608538000168	motif 3; other site
608538000169	motif 2; other site
608538000170	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
608538000171	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
608538000172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
608538000173	Walker A/P-loop; other site
608538000174	ATP binding site [chemical binding]; other site
608538000175	Q-loop/lid; other site
608538000176	ABC transporter signature motif; other site
608538000177	Walker B; other site
608538000178	D-loop; other site
608538000179	H-loop/switch region; other site
608538000180	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
608538000181	ABC-2 type transporter; Region: ABC2_membrane; cl17235
608538000182	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
608538000183	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
608538000184	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
608538000185	intersubunit interface [polypeptide binding]; other site
608538000186	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
608538000187	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
608538000188	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
608538000189	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
608538000190	ABC-ATPase subunit  interface; other site
608538000191	dimer interface [polypeptide binding]; other site
608538000192	putative PBP binding regions; other site
608538000193	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
608538000194	ribonuclease HIII; Region: rnhC; TIGR00716
608538000195	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
608538000196	RNA/DNA hybrid binding site [nucleotide binding]; other site
608538000197	active site
608538000198	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
608538000199	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
608538000200	GAF domain; Region: GAF; pfam01590
608538000201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000202	Walker A motif; other site
608538000203	ATP binding site [chemical binding]; other site
608538000204	Walker B motif; other site
608538000205	arginine finger; other site
608538000206	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
608538000207	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
608538000208	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538000209	PAS fold; Region: PAS_3; pfam08447
608538000210	putative active site [active]
608538000211	heme pocket [chemical binding]; other site
608538000212	PAS domain S-box; Region: sensory_box; TIGR00229
608538000213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538000214	putative active site [active]
608538000215	heme pocket [chemical binding]; other site
608538000216	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
608538000217	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
608538000218	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538000219	metal binding site [ion binding]; metal-binding site
608538000220	active site
608538000221	I-site; other site
608538000222	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
608538000223	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
608538000224	apolar tunnel; other site
608538000225	heme binding site [chemical binding]; other site
608538000226	dimerization interface [polypeptide binding]; other site
608538000227	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
608538000228	heme-binding site [chemical binding]; other site
608538000229	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538000230	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538000231	intracellular protease, PfpI family; Region: PfpI; TIGR01382
608538000232	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
608538000233	conserved cys residue [active]
608538000234	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
608538000235	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
608538000236	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
608538000237	putative RNA binding site [nucleotide binding]; other site
608538000238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000239	S-adenosylmethionine binding site [chemical binding]; other site
608538000240	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
608538000241	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
608538000242	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
608538000243	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
608538000244	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
608538000245	ADP binding site [chemical binding]; other site
608538000246	magnesium binding site [ion binding]; other site
608538000247	putative shikimate binding site; other site
608538000248	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
608538000249	active site
608538000250	multimer interface [polypeptide binding]; other site
608538000251	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
608538000252	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
608538000253	FAD binding pocket [chemical binding]; other site
608538000254	conserved FAD binding motif [chemical binding]; other site
608538000255	phosphate binding motif [ion binding]; other site
608538000256	beta-alpha-beta structure motif; other site
608538000257	NAD binding pocket [chemical binding]; other site
608538000258	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
608538000259	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
608538000260	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
608538000261	quinolinate synthetase; Provisional; Region: PRK09375
608538000262	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
608538000263	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
608538000264	PhoH-like protein; Region: PhoH; pfam02562
608538000265	heat shock protein HtpX; Provisional; Region: PRK03982
608538000266	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
608538000267	proposed catalytic triad [active]
608538000268	conserved cys residue [active]
608538000269	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
608538000270	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
608538000271	NAD binding site [chemical binding]; other site
608538000272	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538000273	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538000274	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
608538000275	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
608538000276	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
608538000277	glutamine binding [chemical binding]; other site
608538000278	catalytic triad [active]
608538000279	acetyl-CoA synthetase; Provisional; Region: PRK00174
608538000280	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
608538000281	active site
608538000282	CoA binding site [chemical binding]; other site
608538000283	acyl-activating enzyme (AAE) consensus motif; other site
608538000284	AMP binding site [chemical binding]; other site
608538000285	acetate binding site [chemical binding]; other site
608538000286	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
608538000287	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
608538000288	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
608538000289	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538000290	N-terminal plug; other site
608538000291	ligand-binding site [chemical binding]; other site
608538000292	DsrE/DsrF-like family; Region: DrsE; pfam02635
608538000293	diaminopimelate decarboxylase; Region: lysA; TIGR01048
608538000294	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
608538000295	active site
608538000296	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538000297	substrate binding site [chemical binding]; other site
608538000298	catalytic residues [active]
608538000299	dimer interface [polypeptide binding]; other site
608538000300	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538000301	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
608538000302	Protein of unknown function (DUF815); Region: DUF815; pfam05673
608538000303	Walker A motif; other site
608538000304	ATP binding site [chemical binding]; other site
608538000305	Walker B motif; other site
608538000306	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
608538000307	ATP-NAD kinase; Region: NAD_kinase; pfam01513
608538000308	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
608538000309	dimer interface [polypeptide binding]; other site
608538000310	active site
608538000311	Ferritin-like domain; Region: Ferritin; pfam00210
608538000312	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
608538000313	dinuclear metal binding motif [ion binding]; other site
608538000314	Ferritin-like domain; Region: Ferritin; pfam00210
608538000315	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
608538000316	dinuclear metal binding motif [ion binding]; other site
608538000317	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538000318	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
608538000319	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
608538000320	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538000321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000322	benzoate transport; Region: 2A0115; TIGR00895
608538000323	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
608538000324	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
608538000325	P loop; other site
608538000326	Nucleotide binding site [chemical binding]; other site
608538000327	DTAP/Switch II; other site
608538000328	Switch I; other site
608538000329	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538000330	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
608538000331	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
608538000332	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
608538000333	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
608538000334	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
608538000335	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
608538000336	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
608538000337	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
608538000338	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538000339	inhibitor-cofactor binding pocket; inhibition site
608538000340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538000341	catalytic residue [active]
608538000342	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
608538000343	Uncharacterized conserved protein [Function unknown]; Region: COG1434
608538000344	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
608538000345	putative active site [active]
608538000346	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
608538000347	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
608538000348	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
608538000349	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
608538000350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000351	binding surface
608538000352	TPR motif; other site
608538000353	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
608538000354	catalytic core [active]
608538000355	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
608538000356	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
608538000357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538000358	catalytic residue [active]
608538000359	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
608538000360	EamA-like transporter family; Region: EamA; pfam00892
608538000361	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
608538000362	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
608538000363	trimer interface [polypeptide binding]; other site
608538000364	putative metal binding site [ion binding]; other site
608538000365	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
608538000366	Phosphoglycerate kinase; Region: PGK; pfam00162
608538000367	substrate binding site [chemical binding]; other site
608538000368	hinge regions; other site
608538000369	ADP binding site [chemical binding]; other site
608538000370	catalytic site [active]
608538000371	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
608538000372	active site
608538000373	ribulose/triose binding site [chemical binding]; other site
608538000374	phosphate binding site [ion binding]; other site
608538000375	substrate (anthranilate) binding pocket [chemical binding]; other site
608538000376	product (indole) binding pocket [chemical binding]; other site
608538000377	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538000378	CPxP  motif; other site
608538000379	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
608538000380	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
608538000381	Transglycosylase; Region: Transgly; pfam00912
608538000382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
608538000383	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611
608538000384	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
608538000385	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
608538000386	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
608538000387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538000388	active site
608538000389	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
608538000390	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
608538000391	5S rRNA interface [nucleotide binding]; other site
608538000392	CTC domain interface [polypeptide binding]; other site
608538000393	L16 interface [polypeptide binding]; other site
608538000394	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
608538000395	putative active site [active]
608538000396	catalytic residue [active]
608538000397	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
608538000398	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
608538000399	TPP-binding site [chemical binding]; other site
608538000400	dimer interface [polypeptide binding]; other site
608538000401	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
608538000402	PYR/PP interface [polypeptide binding]; other site
608538000403	dimer interface [polypeptide binding]; other site
608538000404	TPP binding site [chemical binding]; other site
608538000405	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538000406	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
608538000407	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538000408	catalytic loop [active]
608538000409	iron binding site [ion binding]; other site
608538000410	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
608538000411	4Fe-4S binding domain; Region: Fer4; pfam00037
608538000412	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
608538000413	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538000414	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
608538000415	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
608538000416	putative dimer interface [polypeptide binding]; other site
608538000417	[2Fe-2S] cluster binding site [ion binding]; other site
608538000418	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
608538000419	SLBB domain; Region: SLBB; pfam10531
608538000420	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
608538000421	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
608538000422	Fe-S cluster binding site [ion binding]; other site
608538000423	active site
608538000424	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
608538000425	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
608538000426	homotetramer interface [polypeptide binding]; other site
608538000427	ligand binding site [chemical binding]; other site
608538000428	catalytic site [active]
608538000429	NAD binding site [chemical binding]; other site
608538000430	Isochorismatase family; Region: Isochorismatase; pfam00857
608538000431	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
608538000432	catalytic triad [active]
608538000433	dimer interface [polypeptide binding]; other site
608538000434	conserved cis-peptide bond; other site
608538000435	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
608538000436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000437	S-adenosylmethionine binding site [chemical binding]; other site
608538000438	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
608538000439	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000440	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
608538000441	putative acyl-acceptor binding pocket; other site
608538000442	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
608538000443	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
608538000444	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
608538000445	TrkA-C domain; Region: TrkA_C; pfam02080
608538000446	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
608538000447	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
608538000448	DNA binding residues [nucleotide binding]
608538000449	putative dimer interface [polypeptide binding]; other site
608538000450	chaperone protein DnaJ; Provisional; Region: PRK14291
608538000451	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
608538000452	HSP70 interaction site [polypeptide binding]; other site
608538000453	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
608538000454	Zn binding sites [ion binding]; other site
608538000455	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
608538000456	dimer interface [polypeptide binding]; other site
608538000457	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
608538000458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538000459	S-adenosylmethionine binding site [chemical binding]; other site
608538000460	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
608538000461	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
608538000462	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
608538000463	rod shape-determining protein MreC; Provisional; Region: PRK13922
608538000464	rod shape-determining protein MreC; Region: MreC; pfam04085
608538000465	rod shape-determining protein MreB; Provisional; Region: PRK13927
608538000466	MreB and similar proteins; Region: MreB_like; cd10225
608538000467	nucleotide binding site [chemical binding]; other site
608538000468	Mg binding site [ion binding]; other site
608538000469	putative protofilament interaction site [polypeptide binding]; other site
608538000470	RodZ interaction site [polypeptide binding]; other site
608538000471	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
608538000472	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
608538000473	Zn2+ binding site [ion binding]; other site
608538000474	Mg2+ binding site [ion binding]; other site
608538000475	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
608538000476	synthetase active site [active]
608538000477	NTP binding site [chemical binding]; other site
608538000478	metal binding site [ion binding]; metal-binding site
608538000479	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
608538000480	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
608538000481	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
608538000482	Amidohydrolase; Region: Amidohydro_4; pfam13147
608538000483	active site
608538000484	putative substrate binding pocket [chemical binding]; other site
608538000485	dihydrodipicolinate reductase; Provisional; Region: PRK00048
608538000486	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
608538000487	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
608538000488	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
608538000489	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
608538000490	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538000491	nucleotide binding region [chemical binding]; other site
608538000492	ATP-binding site [chemical binding]; other site
608538000493	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
608538000494	active site
608538000495	SAM binding site [chemical binding]; other site
608538000496	homodimer interface [polypeptide binding]; other site
608538000497	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000498	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
608538000499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538000500	FeS/SAM binding site; other site
608538000501	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
608538000502	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538000503	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
608538000504	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
608538000505	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
608538000506	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000507	Cytochrome c; Region: Cytochrom_C; pfam00034
608538000508	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
608538000509	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
608538000510	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
608538000511	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538000512	Cu(I) binding site [ion binding]; other site
608538000513	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538000514	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
608538000515	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538000516	Low-spin heme binding site [chemical binding]; other site
608538000517	D-pathway; other site
608538000518	Putative water exit pathway; other site
608538000519	Binuclear center (active site) [active]
608538000520	K-pathway; other site
608538000521	Putative proton exit pathway; other site
608538000522	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
608538000523	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
608538000524	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
608538000525	interchain domain interface [polypeptide binding]; other site
608538000526	intrachain domain interface; other site
608538000527	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
608538000528	heme bH binding site [chemical binding]; other site
608538000529	Qi binding site; other site
608538000530	heme bL binding site [chemical binding]; other site
608538000531	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
608538000532	Qo binding site; other site
608538000533	4Fe-4S binding domain; Region: Fer4; pfam00037
608538000534	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
608538000535	4Fe-4S binding domain; Region: Fer4; pfam00037
608538000536	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
608538000537	Cytochrome c; Region: Cytochrom_C; cl11414
608538000538	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
608538000539	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
608538000540	Walker A/P-loop; other site
608538000541	ATP binding site [chemical binding]; other site
608538000542	Q-loop/lid; other site
608538000543	ABC transporter signature motif; other site
608538000544	Walker B; other site
608538000545	D-loop; other site
608538000546	H-loop/switch region; other site
608538000547	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
608538000548	NosL; Region: NosL; cl01769
608538000549	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
608538000550	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
608538000551	Cytochrome c; Region: Cytochrom_C; pfam00034
608538000552	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
608538000553	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
608538000554	catalytic site [active]
608538000555	G-X2-G-X-G-K; other site
608538000556	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
608538000557	Found in ATP-dependent protease La (LON); Region: LON; smart00464
608538000558	Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736
608538000559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000560	Walker A motif; other site
608538000561	ATP binding site [chemical binding]; other site
608538000562	Walker B motif; other site
608538000563	arginine finger; other site
608538000564	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
608538000565	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
608538000566	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
608538000567	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000568	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
608538000569	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
608538000570	heme-binding site [chemical binding]; other site
608538000571	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
608538000572	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
608538000573	hypothetical protein; Validated; Region: PRK00110
608538000574	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
608538000575	homotrimer interaction site [polypeptide binding]; other site
608538000576	putative active site [active]
608538000577	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
608538000578	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
608538000579	dimer interface [polypeptide binding]; other site
608538000580	putative anticodon binding site; other site
608538000581	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
608538000582	motif 1; other site
608538000583	active site
608538000584	motif 2; other site
608538000585	motif 3; other site
608538000586	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
608538000587	core domain interface [polypeptide binding]; other site
608538000588	delta subunit interface [polypeptide binding]; other site
608538000589	epsilon subunit interface [polypeptide binding]; other site
608538000590	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
608538000591	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
608538000592	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
608538000593	alpha subunit interaction interface [polypeptide binding]; other site
608538000594	Walker A motif; other site
608538000595	ATP binding site [chemical binding]; other site
608538000596	Walker B motif; other site
608538000597	inhibitor binding site; inhibition site
608538000598	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
608538000599	ribonuclease PH; Reviewed; Region: rph; PRK00173
608538000600	Ribonuclease PH; Region: RNase_PH_bact; cd11362
608538000601	hexamer interface [polypeptide binding]; other site
608538000602	active site
608538000603	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
608538000604	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
608538000605	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
608538000606	metal binding site [ion binding]; metal-binding site
608538000607	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
608538000608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538000609	Walker A motif; other site
608538000610	ATP binding site [chemical binding]; other site
608538000611	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
608538000612	Walker B motif; other site
608538000613	arginine finger; other site
608538000614	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
608538000615	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
608538000616	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
608538000617	catalytic core [active]
608538000618	Protein of unknown function (DUF429); Region: DUF429; cl12046
608538000619	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
608538000620	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
608538000621	Ligand Binding Site [chemical binding]; other site
608538000622	K+-transporting ATPase, c chain; Region: KdpC; cl00944
608538000623	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
608538000624	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538000625	GYD domain; Region: GYD; cl01743
608538000626	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
608538000627	active site
608538000628	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
608538000629	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
608538000630	active site
608538000631	catalytic residue [active]
608538000632	dimer interface [polypeptide binding]; other site
608538000633	argininosuccinate synthase; Provisional; Region: PRK13820
608538000634	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
608538000635	ANP binding site [chemical binding]; other site
608538000636	Substrate Binding Site II [chemical binding]; other site
608538000637	Substrate Binding Site I [chemical binding]; other site
608538000638	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
608538000639	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
608538000640	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
608538000641	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
608538000642	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
608538000643	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
608538000644	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
608538000645	ThiC family; Region: ThiC; pfam01964
608538000646	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
608538000647	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538000648	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
608538000649	CoA binding domain; Region: CoA_binding; pfam02629
608538000650	CoA-ligase; Region: Ligase_CoA; pfam00549
608538000651	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
608538000652	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
608538000653	acyl-activating enzyme (AAE) consensus motif; other site
608538000654	putative AMP binding site [chemical binding]; other site
608538000655	putative active site [active]
608538000656	putative CoA binding site [chemical binding]; other site
608538000657	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
608538000658	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
608538000659	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
608538000660	putative acyl-acceptor binding pocket; other site
608538000661	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
608538000662	active site
608538000663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538000664	putative substrate translocation pore; other site
608538000665	Major Facilitator Superfamily; Region: MFS_1; pfam07690
608538000666	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
608538000667	substrate binding site; other site
608538000668	dimer interface; other site
608538000669	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853
608538000670	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
608538000671	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
608538000672	Mg++ binding site [ion binding]; other site
608538000673	putative catalytic motif [active]
608538000674	putative substrate binding site [chemical binding]; other site
608538000675	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
608538000676	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
608538000677	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
608538000678	Rrf2 family protein; Region: rrf2_super; TIGR00738
608538000679	Transcriptional regulator; Region: Rrf2; pfam02082
608538000680	ATP cone domain; Region: ATP-cone; pfam03477
608538000681	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
608538000682	Class III ribonucleotide reductase; Region: RNR_III; cd01675
608538000683	effector binding site; other site
608538000684	active site
608538000685	Zn binding site [ion binding]; other site
608538000686	glycine loop; other site
608538000687	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538000688	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
608538000689	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
608538000690	Permease; Region: Permease; cl00510
608538000691	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
608538000692	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
608538000693	Tetramer interface [polypeptide binding]; other site
608538000694	active site
608538000695	FMN-binding site [chemical binding]; other site
608538000696	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
608538000697	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
608538000698	Putative sterol carrier protein [Lipid metabolism]; Region: COG3255
608538000699	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
608538000700	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
608538000701	dimerization interface 3.5A [polypeptide binding]; other site
608538000702	active site
608538000703	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
608538000704	TPR repeat; Region: TPR_11; pfam13414
608538000705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000706	binding surface
608538000707	TPR motif; other site
608538000708	TPR repeat; Region: TPR_11; pfam13414
608538000709	signal recognition particle protein; Provisional; Region: PRK10867
608538000710	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
608538000711	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
608538000712	P loop; other site
608538000713	GTP binding site [chemical binding]; other site
608538000714	Signal peptide binding domain; Region: SRP_SPB; pfam02978
608538000715	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
608538000716	DNA methylase; Region: N6_N4_Mtase; pfam01555
608538000717	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538000718	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538000719	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538000720	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538000721	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
608538000722	catalytic residues [active]
608538000723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538000724	dimerization interface [polypeptide binding]; other site
608538000725	putative DNA binding site [nucleotide binding]; other site
608538000726	putative Zn2+ binding site [ion binding]; other site
608538000727	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
608538000728	Organic solvent tolerance protein; Region: OstA_C; pfam04453
608538000729	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
608538000730	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
608538000731	substrate binding site [chemical binding]; other site
608538000732	hexamer interface [polypeptide binding]; other site
608538000733	metal binding site [ion binding]; metal-binding site
608538000734	PLD-like domain; Region: PLDc_2; pfam13091
608538000735	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
608538000736	putative active site [active]
608538000737	catalytic site [active]
608538000738	Domain of unknown function DUF87; Region: DUF87; pfam01935
608538000739	AAA-like domain; Region: AAA_10; pfam12846
608538000740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
608538000741	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
608538000742	Coenzyme A binding pocket [chemical binding]; other site
608538000743	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
608538000744	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
608538000745	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
608538000746	Peptidase family M28; Region: Peptidase_M28; pfam04389
608538000747	metal binding site [ion binding]; metal-binding site
608538000748	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
608538000749	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
608538000750	homodimer interface [polypeptide binding]; other site
608538000751	substrate-cofactor binding pocket; other site
608538000752	catalytic residue [active]
608538000753	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
608538000754	putative ligand binding pocket/active site [active]
608538000755	putative metal binding site [ion binding]; other site
608538000756	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
608538000757	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
608538000758	tandem repeat interface [polypeptide binding]; other site
608538000759	oligomer interface [polypeptide binding]; other site
608538000760	active site residues [active]
608538000761	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
608538000762	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
608538000763	Walker A/P-loop; other site
608538000764	ATP binding site [chemical binding]; other site
608538000765	Q-loop/lid; other site
608538000766	ABC transporter signature motif; other site
608538000767	Walker B; other site
608538000768	D-loop; other site
608538000769	H-loop/switch region; other site
608538000770	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
608538000771	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538000772	N-terminal plug; other site
608538000773	ligand-binding site [chemical binding]; other site
608538000774	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
608538000775	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
608538000776	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
608538000777	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
608538000778	acyl carrier protein; Provisional; Region: acpP; PRK00982
608538000779	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
608538000780	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
608538000781	dimer interface [polypeptide binding]; other site
608538000782	active site
608538000783	ribonuclease III; Reviewed; Region: rnc; PRK00102
608538000784	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
608538000785	dimerization interface [polypeptide binding]; other site
608538000786	active site
608538000787	metal binding site [ion binding]; metal-binding site
608538000788	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
608538000789	dsRNA binding site [nucleotide binding]; other site
608538000790	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
608538000791	active site
608538000792	metal binding site [ion binding]; metal-binding site
608538000793	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
608538000794	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538000795	minor groove reading motif; other site
608538000796	helix-hairpin-helix signature motif; other site
608538000797	substrate binding pocket [chemical binding]; other site
608538000798	active site
608538000799	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
608538000800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
608538000801	Walker A/P-loop; other site
608538000802	ATP binding site [chemical binding]; other site
608538000803	Q-loop/lid; other site
608538000804	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
608538000805	ABC transporter signature motif; other site
608538000806	Walker B; other site
608538000807	D-loop; other site
608538000808	H-loop/switch region; other site
608538000809	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
608538000810	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
608538000811	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
608538000812	beta subunit interaction interface [polypeptide binding]; other site
608538000813	Walker A motif; other site
608538000814	ATP binding site [chemical binding]; other site
608538000815	Walker B motif; other site
608538000816	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
608538000817	Uncharacterized conserved protein [Function unknown]; Region: COG1801
608538000818	TPR repeat; Region: TPR_11; pfam13414
608538000819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000820	binding surface
608538000821	TPR motif; other site
608538000822	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538000823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538000824	binding surface
608538000825	TPR motif; other site
608538000826	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
608538000827	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
608538000828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
608538000829	Predicted permeases [General function prediction only]; Region: COG0679
608538000830	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
608538000831	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
608538000832	NAD binding site [chemical binding]; other site
608538000833	putative substrate binding site 2 [chemical binding]; other site
608538000834	putative substrate binding site 1 [chemical binding]; other site
608538000835	active site
608538000836	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
608538000837	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
608538000838	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
608538000839	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
608538000840	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
608538000841	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
608538000842	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
608538000843	active site
608538000844	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
608538000845	homodimer interface [polypeptide binding]; other site
608538000846	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
608538000847	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
608538000848	DXD motif; other site
608538000849	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
608538000850	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
608538000851	putative active site [active]
608538000852	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
608538000853	active site
608538000854	hydrophilic channel; other site
608538000855	dimerization interface [polypeptide binding]; other site
608538000856	catalytic residues [active]
608538000857	active site lid [active]
608538000858	4-alpha-glucanotransferase; Provisional; Region: PRK14508
608538000859	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
608538000860	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
608538000861	active site
608538000862	catalytic residues [active]
608538000863	metal binding site [ion binding]; metal-binding site
608538000864	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
608538000865	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
608538000866	Cytochrome c; Region: Cytochrom_C; pfam00034
608538000867	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
608538000868	ResB-like family; Region: ResB; pfam05140
608538000869	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
608538000870	PLD-like domain; Region: PLDc_2; pfam13091
608538000871	putative homodimer interface [polypeptide binding]; other site
608538000872	putative active site [active]
608538000873	catalytic site [active]
608538000874	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
608538000875	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
608538000876	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538000877	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
608538000878	nucleotide binding region [chemical binding]; other site
608538000879	ATP-binding site [chemical binding]; other site
608538000880	Transposase IS200 like; Region: Y1_Tnp; pfam01797
608538000881	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
608538000882	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
608538000883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
608538000884	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
608538000885	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538000886	active site
608538000887	NTP binding site [chemical binding]; other site
608538000888	metal binding triad [ion binding]; metal-binding site
608538000889	antibiotic binding site [chemical binding]; other site
608538000890	Uncharacterized conserved protein [Function unknown]; Region: COG2361
608538000891	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
608538000892	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
608538000893	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000894	active site
608538000895	HIGH motif; other site
608538000896	nucleotide binding site [chemical binding]; other site
608538000897	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
608538000898	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000899	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538000900	active site
608538000901	KMSKS motif; other site
608538000902	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
608538000903	tRNA binding surface [nucleotide binding]; other site
608538000904	anticodon binding site; other site
608538000905	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
608538000906	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
608538000907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538000908	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
608538000909	NAD(P) binding site [chemical binding]; other site
608538000910	active site
608538000911	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
608538000912	feedback inhibition sensing region; other site
608538000913	homohexameric interface [polypeptide binding]; other site
608538000914	nucleotide binding site [chemical binding]; other site
608538000915	N-acetyl-L-glutamate binding site [chemical binding]; other site
608538000916	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
608538000917	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
608538000918	active site
608538000919	DNA binding site [nucleotide binding]
608538000920	Int/Topo IB signature motif; other site
608538000921	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
608538000922	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
608538000923	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
608538000924	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
608538000925	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
608538000926	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538000927	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538000928	FeS/SAM binding site; other site
608538000929	Fumarase C-terminus; Region: Fumerase_C; cl00795
608538000930	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
608538000931	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
608538000932	Walker A motif; other site
608538000933	ATP binding site [chemical binding]; other site
608538000934	Walker B motif; other site
608538000935	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538000936	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
608538000937	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
608538000938	GTP-binding protein YchF; Reviewed; Region: PRK09601
608538000939	YchF GTPase; Region: YchF; cd01900
608538000940	G1 box; other site
608538000941	GTP/Mg2+ binding site [chemical binding]; other site
608538000942	Switch I region; other site
608538000943	G2 box; other site
608538000944	Switch II region; other site
608538000945	G3 box; other site
608538000946	G4 box; other site
608538000947	G5 box; other site
608538000948	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
608538000949	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538000950	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538000951	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
608538000952	putative active site [active]
608538000953	putative metal binding site [ion binding]; other site
608538000954	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
608538000955	Catalytic domain of Protein Kinases; Region: PKc; cd00180
608538000956	active site
608538000957	ATP binding site [chemical binding]; other site
608538000958	substrate binding site [chemical binding]; other site
608538000959	activation loop (A-loop); other site
608538000960	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
608538000961	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
608538000962	active site
608538000963	NAD binding site [chemical binding]; other site
608538000964	metal binding site [ion binding]; metal-binding site
608538000965	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
608538000966	SurA N-terminal domain; Region: SurA_N_3; pfam13624
608538000967	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
608538000968	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
608538000969	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
608538000970	active site
608538000971	oxalacetate binding site [chemical binding]; other site
608538000972	citrylCoA binding site [chemical binding]; other site
608538000973	coenzyme A binding site [chemical binding]; other site
608538000974	catalytic triad [active]
608538000975	homoserine dehydrogenase; Provisional; Region: PRK06349
608538000976	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
608538000977	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
608538000978	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
608538000979	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
608538000980	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
608538000981	active site
608538000982	DNA repair protein RadA; Provisional; Region: PRK11823
608538000983	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
608538000984	Walker A motif/ATP binding site; other site
608538000985	ATP binding site [chemical binding]; other site
608538000986	Walker B motif; other site
608538000987	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
608538000988	FeoA domain; Region: FeoA; pfam04023
608538000989	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
608538000990	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
608538000991	G1 box; other site
608538000992	GTP/Mg2+ binding site [chemical binding]; other site
608538000993	Switch I region; other site
608538000994	G2 box; other site
608538000995	G3 box; other site
608538000996	Switch II region; other site
608538000997	G4 box; other site
608538000998	G5 box; other site
608538000999	Nucleoside recognition; Region: Gate; pfam07670
608538001000	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
608538001001	Nucleoside recognition; Region: Gate; pfam07670
608538001002	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538001003	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
608538001004	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
608538001005	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
608538001006	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
608538001007	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
608538001008	active site
608538001009	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
608538001010	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
608538001011	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
608538001012	putative substrate binding pocket [chemical binding]; other site
608538001013	dimer interface [polypeptide binding]; other site
608538001014	phosphate binding site [ion binding]; other site
608538001015	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
608538001016	L-aspartate oxidase; Provisional; Region: PRK06175
608538001017	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
608538001018	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
608538001019	tetramer interfaces [polypeptide binding]; other site
608538001020	binuclear metal-binding site [ion binding]; other site
608538001021	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
608538001022	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
608538001023	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
608538001024	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
608538001025	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
608538001026	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
608538001027	tRNA; other site
608538001028	putative tRNA binding site [nucleotide binding]; other site
608538001029	putative NADP binding site [chemical binding]; other site
608538001030	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
608538001031	AsnC family; Region: AsnC_trans_reg; pfam01037
608538001032	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
608538001033	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
608538001034	hinge; other site
608538001035	active site
608538001036	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
608538001037	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
608538001038	putative dimer interface [polypeptide binding]; other site
608538001039	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
608538001040	Isochorismatase family; Region: Isochorismatase; pfam00857
608538001041	catalytic triad [active]
608538001042	metal binding site [ion binding]; metal-binding site
608538001043	conserved cis-peptide bond; other site
608538001044	Sugar fermentation stimulation protein; Region: SfsA; cl00647
608538001045	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538001046	G2 box; other site
608538001047	Switch I region; other site
608538001048	G3 box; other site
608538001049	Switch II region; other site
608538001050	GTP/Mg2+ binding site [chemical binding]; other site
608538001051	G4 box; other site
608538001052	G5 box; other site
608538001053	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
608538001054	HEAT repeats; Region: HEAT_2; pfam13646
608538001055	Ferrochelatase; Region: Ferrochelatase; pfam00762
608538001056	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
608538001057	C-terminal domain interface [polypeptide binding]; other site
608538001058	active site
608538001059	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
608538001060	active site
608538001061	N-terminal domain interface [polypeptide binding]; other site
608538001062	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
608538001063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
608538001064	Walker A/P-loop; other site
608538001065	ATP binding site [chemical binding]; other site
608538001066	Q-loop/lid; other site
608538001067	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
608538001068	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
608538001069	ABC transporter signature motif; other site
608538001070	Walker B; other site
608538001071	D-loop; other site
608538001072	H-loop/switch region; other site
608538001073	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
608538001074	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
608538001075	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
608538001076	Uncharacterized conserved protein [Function unknown]; Region: COG1432
608538001077	LabA_like proteins; Region: LabA_like/DUF88; cl10034
608538001078	putative metal binding site [ion binding]; other site
608538001079	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
608538001080	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
608538001081	active site
608538001082	Riboflavin kinase; Region: Flavokinase; pfam01687
608538001083	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
608538001084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
608538001085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001086	Walker A motif; other site
608538001087	ATP binding site [chemical binding]; other site
608538001088	Walker B motif; other site
608538001089	arginine finger; other site
608538001090	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
608538001091	Putative sterol carrier protein [Lipid metabolism]; Region: COG3255
608538001092	Roadblock/LC7 domain [Function unknown]; Region: COG4831
608538001093	Roadblock/LC7 domain [Function unknown]; Region: COG4831
608538001094	Hemerythrin-like domain; Region: Hr-like; cd12108
608538001095	Fe binding site [ion binding]; other site
608538001096	K+ potassium transporter; Region: K_trans; pfam02705
608538001097	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
608538001098	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
608538001099	dimer interface [polypeptide binding]; other site
608538001100	anticodon binding site; other site
608538001101	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
608538001102	homodimer interface [polypeptide binding]; other site
608538001103	motif 1; other site
608538001104	active site
608538001105	motif 2; other site
608538001106	GAD domain; Region: GAD; pfam02938
608538001107	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
608538001108	motif 3; other site
608538001109	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538001110	active site
608538001111	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
608538001112	histidinol dehydrogenase; Region: hisD; TIGR00069
608538001113	NAD binding site [chemical binding]; other site
608538001114	dimerization interface [polypeptide binding]; other site
608538001115	product binding site; other site
608538001116	substrate binding site [chemical binding]; other site
608538001117	zinc binding site [ion binding]; other site
608538001118	catalytic residues [active]
608538001119	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
608538001120	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538001121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001122	homodimer interface [polypeptide binding]; other site
608538001123	catalytic residue [active]
608538001124	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
608538001125	FOG: CBS domain [General function prediction only]; Region: COG0517
608538001126	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
608538001127	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
608538001128	active site
608538001129	Zn binding site [ion binding]; other site
608538001130	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
608538001131	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
608538001132	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
608538001133	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
608538001134	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
608538001135	Domain of unknown function DUF20; Region: UPF0118; pfam01594
608538001136	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001137	TPR motif; other site
608538001138	binding surface
608538001139	TPR repeat; Region: TPR_11; pfam13414
608538001140	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
608538001141	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
608538001142	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
608538001143	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
608538001144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001145	catalytic residue [active]
608538001146	ribonuclease R; Region: RNase_R; TIGR02063
608538001147	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
608538001148	RNB domain; Region: RNB; pfam00773
608538001149	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
608538001150	RNA binding site [nucleotide binding]; other site
608538001151	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
608538001152	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
608538001153	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
608538001154	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
608538001155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538001156	dimer interface [polypeptide binding]; other site
608538001157	conserved gate region; other site
608538001158	putative PBP binding loops; other site
608538001159	ABC-ATPase subunit interface; other site
608538001160	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
608538001161	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
608538001162	FAD binding pocket [chemical binding]; other site
608538001163	FAD binding motif [chemical binding]; other site
608538001164	phosphate binding motif [ion binding]; other site
608538001165	beta-alpha-beta structure motif; other site
608538001166	NAD binding pocket [chemical binding]; other site
608538001167	Iron coordination center [ion binding]; other site
608538001168	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
608538001169	Lumazine binding domain; Region: Lum_binding; pfam00677
608538001170	Lumazine binding domain; Region: Lum_binding; pfam00677
608538001171	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
608538001172	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
608538001173	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
608538001174	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
608538001175	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
608538001176	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
608538001177	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
608538001178	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
608538001179	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
608538001180	dimer interface [polypeptide binding]; other site
608538001181	ssDNA binding site [nucleotide binding]; other site
608538001182	tetramer (dimer of dimers) interface [polypeptide binding]; other site
608538001183	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
608538001184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
608538001185	Coenzyme A binding pocket [chemical binding]; other site
608538001186	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
608538001187	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
608538001188	catalytic site [active]
608538001189	putative active site [active]
608538001190	putative substrate binding site [chemical binding]; other site
608538001191	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
608538001192	active site
608538001193	DNA binding site [nucleotide binding]
608538001194	catalytic site [active]
608538001195	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
608538001196	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
608538001197	putative active site [active]
608538001198	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
608538001199	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
608538001200	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
608538001201	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
608538001202	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
608538001203	Cytochrome c; Region: Cytochrom_C; cl11414
608538001204	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
608538001205	putative hydrophobic ligand binding site [chemical binding]; other site
608538001206	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
608538001207	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
608538001208	XdhC Rossmann domain; Region: XdhC_C; pfam13478
608538001209	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
608538001210	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
608538001211	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
608538001212	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
608538001213	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538001214	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
608538001215	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538001216	catalytic loop [active]
608538001217	iron binding site [ion binding]; other site
608538001218	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
608538001219	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
608538001220	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538001221	N-terminal plug; other site
608538001222	ligand-binding site [chemical binding]; other site
608538001223	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
608538001224	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
608538001225	membrane-bound complex binding site; other site
608538001226	hinge residues; other site
608538001227	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
608538001228	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
608538001229	structural tetrad; other site
608538001230	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
608538001231	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
608538001232	Trp docking motif [polypeptide binding]; other site
608538001233	dimer interface [polypeptide binding]; other site
608538001234	active site
608538001235	small subunit binding site [polypeptide binding]; other site
608538001236	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
608538001237	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
608538001238	putative ligand binding site [chemical binding]; other site
608538001239	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
608538001240	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
608538001241	TM-ABC transporter signature motif; other site
608538001242	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
608538001243	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
608538001244	TM-ABC transporter signature motif; other site
608538001245	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
608538001246	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
608538001247	Walker A/P-loop; other site
608538001248	ATP binding site [chemical binding]; other site
608538001249	Q-loop/lid; other site
608538001250	ABC transporter signature motif; other site
608538001251	Walker B; other site
608538001252	D-loop; other site
608538001253	H-loop/switch region; other site
608538001254	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
608538001255	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
608538001256	Walker A/P-loop; other site
608538001257	ATP binding site [chemical binding]; other site
608538001258	Q-loop/lid; other site
608538001259	ABC transporter signature motif; other site
608538001260	Walker B; other site
608538001261	D-loop; other site
608538001262	H-loop/switch region; other site
608538001263	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
608538001264	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
608538001265	Radical SAM superfamily; Region: Radical_SAM; pfam04055
608538001266	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001267	FeS/SAM binding site; other site
608538001268	PSP1 C-terminal conserved region; Region: PSP1; cl00770
608538001269	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
608538001270	4Fe-4S binding domain; Region: Fer4; pfam00037
608538001271	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
608538001272	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
608538001273	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713
608538001274	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
608538001275	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
608538001276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538001277	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
608538001278	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538001279	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
608538001280	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538001281	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
608538001282	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
608538001283	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
608538001284	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
608538001285	NADH dehydrogenase subunit D; Validated; Region: PRK06075
608538001286	NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005
608538001287	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
608538001288	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
608538001289	substrate binding site [chemical binding]; other site
608538001290	glutamase interaction surface [polypeptide binding]; other site
608538001291	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
608538001292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538001293	ATP binding site [chemical binding]; other site
608538001294	Mg2+ binding site [ion binding]; other site
608538001295	G-X-G motif; other site
608538001296	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
608538001297	ATP binding site [chemical binding]; other site
608538001298	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
608538001299	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
608538001300	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
608538001301	heterodimer interface [polypeptide binding]; other site
608538001302	active site
608538001303	FMN binding site [chemical binding]; other site
608538001304	homodimer interface [polypeptide binding]; other site
608538001305	substrate binding site [chemical binding]; other site
608538001306	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
608538001307	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
608538001308	GDP-binding site [chemical binding]; other site
608538001309	ACT binding site; other site
608538001310	IMP binding site; other site
608538001311	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
608538001312	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
608538001313	HflX GTPase family; Region: HflX; cd01878
608538001314	G1 box; other site
608538001315	GTP/Mg2+ binding site [chemical binding]; other site
608538001316	Switch I region; other site
608538001317	G2 box; other site
608538001318	G3 box; other site
608538001319	Switch II region; other site
608538001320	G4 box; other site
608538001321	G5 box; other site
608538001322	bacterial Hfq-like; Region: Hfq; cd01716
608538001323	hexamer interface [polypeptide binding]; other site
608538001324	Sm1 motif; other site
608538001325	RNA binding site [nucleotide binding]; other site
608538001326	Sm2 motif; other site
608538001327	acetylornithine aminotransferase; Provisional; Region: PRK02627
608538001328	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538001329	inhibitor-cofactor binding pocket; inhibition site
608538001330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001331	catalytic residue [active]
608538001332	NAD synthetase; Provisional; Region: PRK13981
608538001333	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
608538001334	multimer interface [polypeptide binding]; other site
608538001335	active site
608538001336	catalytic triad [active]
608538001337	protein interface 1 [polypeptide binding]; other site
608538001338	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
608538001339	homodimer interface [polypeptide binding]; other site
608538001340	NAD binding pocket [chemical binding]; other site
608538001341	ATP binding pocket [chemical binding]; other site
608538001342	Mg binding site [ion binding]; other site
608538001343	active-site loop [active]
608538001344	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
608538001345	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538001346	Walker A motif; other site
608538001347	ATP binding site [chemical binding]; other site
608538001348	Walker B motif; other site
608538001349	Preprotein translocase subunit; Region: YajC; cl00806
608538001350	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538001351	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538001352	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538001353	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14953
608538001354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001355	Walker A motif; other site
608538001356	ATP binding site [chemical binding]; other site
608538001357	Walker B motif; other site
608538001358	arginine finger; other site
608538001359	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
608538001360	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
608538001361	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
608538001362	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
608538001363	putative active site [active]
608538001364	catalytic triad [active]
608538001365	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
608538001366	hypothetical protein; Reviewed; Region: PRK12497
608538001367	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
608538001368	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
608538001369	putative ribose interaction site [chemical binding]; other site
608538001370	putative ADP binding site [chemical binding]; other site
608538001371	aspartate kinase; Reviewed; Region: PRK06635
608538001372	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
608538001373	putative nucleotide binding site [chemical binding]; other site
608538001374	putative catalytic residues [active]
608538001375	putative Mg ion binding site [ion binding]; other site
608538001376	putative aspartate binding site [chemical binding]; other site
608538001377	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
608538001378	putative allosteric regulatory site; other site
608538001379	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
608538001380	putative allosteric regulatory residue; other site
608538001381	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
608538001382	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538001383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538001384	Walker A motif; other site
608538001385	ATP binding site [chemical binding]; other site
608538001386	Walker B motif; other site
608538001387	arginine finger; other site
608538001388	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
608538001389	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538001390	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538001391	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538001392	MoaE interaction surface [polypeptide binding]; other site
608538001393	MoeB interaction surface [polypeptide binding]; other site
608538001394	thiocarboxylated glycine; other site
608538001395	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
608538001396	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
608538001397	Active Sites [active]
608538001398	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
608538001399	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
608538001400	active site
608538001401	SAM binding site [chemical binding]; other site
608538001402	homodimer interface [polypeptide binding]; other site
608538001403	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
608538001404	ATP-sulfurylase; Region: ATPS; cd00517
608538001405	active site
608538001406	HXXH motif; other site
608538001407	flexible loop; other site
608538001408	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538001409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538001410	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538001411	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538001412	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538001413	V4R domain; Region: V4R; pfam02830
608538001414	NifU-like domain; Region: NifU; cl00484
608538001415	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
608538001416	iron-sulfur cluster [ion binding]; other site
608538001417	[2Fe-2S] cluster binding site [ion binding]; other site
608538001418	TPR repeat; Region: TPR_11; pfam13414
608538001419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001420	binding surface
608538001421	TPR motif; other site
608538001422	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001423	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
608538001424	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
608538001425	nickel binding site [ion binding]; other site
608538001426	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
608538001427	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
608538001428	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
608538001429	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
608538001430	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
608538001431	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
608538001432	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
608538001433	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
608538001434	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
608538001435	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
608538001436	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
608538001437	Walker A/P-loop; other site
608538001438	ATP binding site [chemical binding]; other site
608538001439	Q-loop/lid; other site
608538001440	ABC transporter signature motif; other site
608538001441	Walker B; other site
608538001442	D-loop; other site
608538001443	H-loop/switch region; other site
608538001444	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
608538001445	active site
608538001446	catalytic residues [active]
608538001447	metal binding site [ion binding]; metal-binding site
608538001448	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
608538001449	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
608538001450	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
608538001451	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
608538001452	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
608538001453	PhoU domain; Region: PhoU; pfam01895
608538001454	PhoU domain; Region: PhoU; pfam01895
608538001455	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
608538001456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
608538001457	dimerization interface [polypeptide binding]; other site
608538001458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538001459	dimer interface [polypeptide binding]; other site
608538001460	phosphorylation site [posttranslational modification]
608538001461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538001462	ATP binding site [chemical binding]; other site
608538001463	Mg2+ binding site [ion binding]; other site
608538001464	G-X-G motif; other site
608538001465	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
608538001466	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538001467	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
608538001468	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
608538001469	AAA domain; Region: AAA_32; pfam13654
608538001470	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
608538001471	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
608538001472	Uncharacterized conserved protein [Function unknown]; Region: COG0011
608538001473	YceG-like family; Region: YceG; pfam02618
608538001474	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
608538001475	dimerization interface [polypeptide binding]; other site
608538001476	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
608538001477	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
608538001478	Protein of unknown function (DUF1122); Region: DUF1122; cl01800
608538001479	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
608538001480	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
608538001481	dimer interface [polypeptide binding]; other site
608538001482	motif 1; other site
608538001483	active site
608538001484	motif 2; other site
608538001485	motif 3; other site
608538001486	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
608538001487	anticodon binding site; other site
608538001488	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
608538001489	dimer interface [polypeptide binding]; other site
608538001490	active site
608538001491	Schiff base residues; other site
608538001492	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14331
608538001493	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
608538001494	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001495	FeS/SAM binding site; other site
608538001496	TRAM domain; Region: TRAM; pfam01938
608538001497	Bifunctional nuclease; Region: DNase-RNase; pfam02577
608538001498	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
608538001499	Peptidase family M50; Region: Peptidase_M50; pfam02163
608538001500	active site
608538001501	putative substrate binding region [chemical binding]; other site
608538001502	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
608538001503	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
608538001504	NAD(P) binding site [chemical binding]; other site
608538001505	homotetramer interface [polypeptide binding]; other site
608538001506	homodimer interface [polypeptide binding]; other site
608538001507	active site
608538001508	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
608538001509	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
608538001510	active site
608538001511	metal binding site [ion binding]; metal-binding site
608538001512	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
608538001513	domain I; other site
608538001514	DNA binding groove [nucleotide binding]
608538001515	phosphate binding site [ion binding]; other site
608538001516	domain II; other site
608538001517	domain III; other site
608538001518	nucleotide binding site [chemical binding]; other site
608538001519	catalytic site [active]
608538001520	domain IV; other site
608538001521	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
608538001522	bacterial Hfq-like; Region: Hfq; cd01716
608538001523	hexamer interface [polypeptide binding]; other site
608538001524	Sm1 motif; other site
608538001525	RNA binding site [nucleotide binding]; other site
608538001526	Sm2 motif; other site
608538001527	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
608538001528	dimer interface [polypeptide binding]; other site
608538001529	[2Fe-2S] cluster binding site [ion binding]; other site
608538001530	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
608538001531	Part of AAA domain; Region: AAA_19; pfam13245
608538001532	Family description; Region: UvrD_C_2; pfam13538
608538001533	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538001534	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
608538001535	Protein of unknown function (DUF554); Region: DUF554; pfam04474
608538001536	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
608538001537	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
608538001538	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
608538001539	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
608538001540	G1 box; other site
608538001541	GTP/Mg2+ binding site [chemical binding]; other site
608538001542	Switch I region; other site
608538001543	G2 box; other site
608538001544	G3 box; other site
608538001545	Switch II region; other site
608538001546	G4 box; other site
608538001547	G5 box; other site
608538001548	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
608538001549	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538001550	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538001551	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
608538001552	DNA-binding site [nucleotide binding]; DNA binding site
608538001553	RNA-binding motif; other site
608538001554	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
608538001555	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
608538001556	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
608538001557	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
608538001558	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
608538001559	putative NAD(P) binding site [chemical binding]; other site
608538001560	active site
608538001561	Predicted transcriptional regulators [Transcription]; Region: COG1318
608538001562	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
608538001563	MTH865-like family; Region: MTH865; cl01962
608538001564	Family of unknown function (DUF490); Region: DUF490; pfam04357
608538001565	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
608538001566	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
608538001567	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
608538001568	putative active site [active]
608538001569	catalytic triad [active]
608538001570	putative dimer interface [polypeptide binding]; other site
608538001571	EamA-like transporter family; Region: EamA; cl17759
608538001572	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
608538001573	putative catalytic site [active]
608538001574	putative phosphate binding site [ion binding]; other site
608538001575	active site
608538001576	metal binding site A [ion binding]; metal-binding site
608538001577	DNA binding site [nucleotide binding]
608538001578	putative AP binding site [nucleotide binding]; other site
608538001579	putative metal binding site B [ion binding]; other site
608538001580	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538001581	IHF dimer interface [polypeptide binding]; other site
608538001582	IHF - DNA interface [nucleotide binding]; other site
608538001583	RecT family; Region: RecT; pfam03837
608538001584	Cyclin-dependent kinase regulatory subunit; Region: CKS; cl03104
608538001585	Predicted transcriptional regulator [Transcription]; Region: COG2932
608538001586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538001587	sequence-specific DNA binding site [nucleotide binding]; other site
608538001588	salt bridge; other site
608538001589	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
608538001590	Catalytic site [active]
608538001591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538001592	sequence-specific DNA binding site [nucleotide binding]; other site
608538001593	salt bridge; other site
608538001594	CHC2 zinc finger; Region: zf-CHC2; cl17510
608538001595	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
608538001596	Part of AAA domain; Region: AAA_19; pfam13245
608538001597	Family description; Region: UvrD_C_2; pfam13538
608538001598	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
608538001599	active site
608538001600	putative DNA-binding cleft [nucleotide binding]; other site
608538001601	dimer interface [polypeptide binding]; other site
608538001602	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
608538001603	Active Sites [active]
608538001604	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
608538001605	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
608538001606	active site
608538001607	metal binding site [ion binding]; metal-binding site
608538001608	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
608538001609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
608538001610	Terminase-like family; Region: Terminase_6; pfam03237
608538001611	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
608538001612	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
608538001613	sugar binding site [chemical binding]; other site
608538001614	replication factor A; Reviewed; Region: PRK08402
608538001615	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
608538001616	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
608538001617	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
608538001618	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538001619	catalytic residue [active]
608538001620	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
608538001621	putative DNA binding surface [nucleotide binding]; other site
608538001622	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
608538001623	dimer interface [polypeptide binding]; other site
608538001624	beta-clamp/clamp loader binding surface; other site
608538001625	beta-clamp/translesion DNA polymerase binding surface; other site
608538001626	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
608538001627	DHH family; Region: DHH; pfam01368
608538001628	FOG: CBS domain [General function prediction only]; Region: COG0517
608538001629	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
608538001630	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
608538001631	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
608538001632	active site
608538001633	NTP binding site [chemical binding]; other site
608538001634	metal binding triad [ion binding]; metal-binding site
608538001635	Predicted permease; Region: DUF318; cl17795
608538001636	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
608538001637	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
608538001638	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538001639	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
608538001640	G1 box; other site
608538001641	GTP/Mg2+ binding site [chemical binding]; other site
608538001642	G2 box; other site
608538001643	Switch I region; other site
608538001644	G3 box; other site
608538001645	Switch II region; other site
608538001646	G4 box; other site
608538001647	G5 box; other site
608538001648	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
608538001649	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
608538001650	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
608538001651	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
608538001652	23S rRNA interface [nucleotide binding]; other site
608538001653	L3 interface [polypeptide binding]; other site
608538001654	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
608538001655	substrate binding site [chemical binding]; other site
608538001656	lipoyl synthase; Provisional; Region: PRK05481
608538001657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001658	FeS/SAM binding site; other site
608538001659	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
608538001660	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
608538001661	FAD binding pocket [chemical binding]; other site
608538001662	FAD binding motif [chemical binding]; other site
608538001663	phosphate binding motif [ion binding]; other site
608538001664	beta-alpha-beta structure motif; other site
608538001665	NAD binding pocket [chemical binding]; other site
608538001666	Iron coordination center [ion binding]; other site
608538001667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538001668	Outer membrane efflux protein; Region: OEP; pfam02321
608538001669	Outer membrane efflux protein; Region: OEP; pfam02321
608538001670	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
608538001671	catalytic residues [active]
608538001672	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
608538001673	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
608538001674	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
608538001675	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001676	TPR motif; other site
608538001677	binding surface
608538001678	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001679	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001680	binding surface
608538001681	TPR motif; other site
608538001682	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538001684	binding surface
608538001685	TPR motif; other site
608538001686	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538001687	Protein of unknown function (DUF503); Region: DUF503; pfam04456
608538001688	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
608538001689	MPN+ (JAMM) motif; other site
608538001690	Zinc-binding site [ion binding]; other site
608538001691	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
608538001692	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
608538001693	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538001694	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
608538001695	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
608538001696	putative amphipathic alpha helix; other site
608538001697	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
608538001698	peptide chain release factor 2; Validated; Region: prfB; PRK00578
608538001699	This domain is found in peptide chain release factors; Region: PCRF; smart00937
608538001700	RF-1 domain; Region: RF-1; pfam00472
608538001701	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
608538001702	GTP1/OBG; Region: GTP1_OBG; pfam01018
608538001703	Obg GTPase; Region: Obg; cd01898
608538001704	G1 box; other site
608538001705	GTP/Mg2+ binding site [chemical binding]; other site
608538001706	Switch I region; other site
608538001707	G2 box; other site
608538001708	G3 box; other site
608538001709	Switch II region; other site
608538001710	G4 box; other site
608538001711	G5 box; other site
608538001712	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538001713	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
608538001714	catalytic residues [active]
608538001715	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
608538001716	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538001717	catalytic residue [active]
608538001718	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
608538001719	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
608538001720	HIGH motif; other site
608538001721	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
608538001722	active site
608538001723	KMSKS motif; other site
608538001724	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
608538001725	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
608538001726	active site
608538001727	homodimer interface [polypeptide binding]; other site
608538001728	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
608538001729	active site
608538001730	tetramer interface; other site
608538001731	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538001732	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538001733	Surface antigen; Region: Bac_surface_Ag; pfam01103
608538001734	aspartate aminotransferase; Provisional; Region: PRK05764
608538001735	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538001736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538001737	homodimer interface [polypeptide binding]; other site
608538001738	catalytic residue [active]
608538001739	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
608538001740	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
608538001741	ligand binding site [chemical binding]; other site
608538001742	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
608538001743	dimer interface [polypeptide binding]; other site
608538001744	putative tRNA-binding site [nucleotide binding]; other site
608538001745	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538001746	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
608538001747	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
608538001748	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
608538001749	dimer interface [polypeptide binding]; other site
608538001750	putative functional site; other site
608538001751	putative MPT binding site; other site
608538001752	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
608538001753	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
608538001754	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
608538001755	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
608538001756	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
608538001757	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
608538001758	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
608538001759	triosephosphate isomerase; Provisional; Region: PRK14565
608538001760	substrate binding site [chemical binding]; other site
608538001761	dimer interface [polypeptide binding]; other site
608538001762	catalytic triad [active]
608538001763	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
608538001764	UbiA prenyltransferase family; Region: UbiA; pfam01040
608538001765	replicative DNA helicase; Region: DnaB; TIGR00665
608538001766	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
608538001767	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
608538001768	Walker A motif; other site
608538001769	ATP binding site [chemical binding]; other site
608538001770	Walker B motif; other site
608538001771	DNA binding loops [nucleotide binding]
608538001772	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
608538001773	FAD binding site [chemical binding]; other site
608538001774	GYD domain; Region: GYD; pfam08734
608538001775	Cytochrome c; Region: Cytochrom_C; pfam00034
608538001776	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
608538001777	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
608538001778	Ligand Binding Site [chemical binding]; other site
608538001779	TIGR00269 family protein; Region: TIGR00269
608538001780	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
608538001781	active site residue [active]
608538001782	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
608538001783	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538001784	catalytic residue [active]
608538001785	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
608538001786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001787	S-adenosylmethionine binding site [chemical binding]; other site
608538001788	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
608538001789	Domain of unknown function DUF21; Region: DUF21; pfam01595
608538001790	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
608538001791	Transporter associated domain; Region: CorC_HlyC; smart01091
608538001792	hypothetical protein; Reviewed; Region: PRK00024
608538001793	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
608538001794	MPN+ (JAMM) motif; other site
608538001795	Zinc-binding site [ion binding]; other site
608538001796	putative phosphoketolase; Provisional; Region: PRK05261
608538001797	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
608538001798	TPP-binding site; other site
608538001799	XFP C-terminal domain; Region: XFP_C; pfam09363
608538001800	Acetokinase family; Region: Acetate_kinase; cl17229
608538001801	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
608538001802	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
608538001803	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
608538001804	homodimer interface [polypeptide binding]; other site
608538001805	NADP binding site [chemical binding]; other site
608538001806	substrate binding site [chemical binding]; other site
608538001807	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538001808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001809	S-adenosylmethionine binding site [chemical binding]; other site
608538001810	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
608538001811	Cytochrome c; Region: Cytochrom_C; cl11414
608538001812	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
608538001813	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
608538001814	Nucleotide binding site [chemical binding]; other site
608538001815	DTAP/Switch II; other site
608538001816	Switch I; other site
608538001817	amino acid transporter; Region: 2A0306; TIGR00909
608538001818	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
608538001819	Staphylococcal nuclease homologues; Region: SNc; smart00318
608538001820	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
608538001821	Catalytic site; other site
608538001822	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
608538001823	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
608538001824	PYR/PP interface [polypeptide binding]; other site
608538001825	dimer interface [polypeptide binding]; other site
608538001826	TPP binding site [chemical binding]; other site
608538001827	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
608538001828	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
608538001829	TPP-binding site [chemical binding]; other site
608538001830	dimer interface [polypeptide binding]; other site
608538001831	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
608538001832	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
608538001833	putative valine binding site [chemical binding]; other site
608538001834	dimer interface [polypeptide binding]; other site
608538001835	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
608538001836	multifunctional aminopeptidase A; Provisional; Region: PRK00913
608538001837	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
608538001838	interface (dimer of trimers) [polypeptide binding]; other site
608538001839	Substrate-binding/catalytic site; other site
608538001840	Zn-binding sites [ion binding]; other site
608538001841	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
608538001842	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
608538001843	dimerization interface [polypeptide binding]; other site
608538001844	active site
608538001845	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538001846	glycogen synthase; Provisional; Region: glgA; PRK00654
608538001847	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
608538001848	ADP-binding pocket [chemical binding]; other site
608538001849	homodimer interface [polypeptide binding]; other site
608538001850	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
608538001851	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
608538001852	active site
608538001853	nucleotide binding site [chemical binding]; other site
608538001854	HIGH motif; other site
608538001855	KMSKS motif; other site
608538001856	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538001857	active site
608538001858	NTP binding site [chemical binding]; other site
608538001859	metal binding triad [ion binding]; metal-binding site
608538001860	antibiotic binding site [chemical binding]; other site
608538001861	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
608538001862	Recombination protein O N terminal; Region: RecO_N; pfam11967
608538001863	Pantoate-beta-alanine ligase; Region: PanC; cd00560
608538001864	pantoate--beta-alanine ligase; Region: panC; TIGR00018
608538001865	active site
608538001866	ATP-binding site [chemical binding]; other site
608538001867	pantoate-binding site; other site
608538001868	HXXH motif; other site
608538001869	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
608538001870	homopentamer interface [polypeptide binding]; other site
608538001871	active site
608538001872	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
608538001873	putative RNA binding site [nucleotide binding]; other site
608538001874	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
608538001875	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
608538001876	catalytic residues [active]
608538001877	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
608538001878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538001879	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538001880	DNA binding residues [nucleotide binding]
608538001881	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
608538001882	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538001883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
608538001884	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
608538001885	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
608538001886	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
608538001887	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
608538001888	radical SAM protein, TIGR01212 family; Region: TIGR01212
608538001889	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001890	FeS/SAM binding site; other site
608538001891	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
608538001892	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
608538001893	dihydroorotase; Validated; Region: pyrC; PRK09357
608538001894	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
608538001895	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
608538001896	active site
608538001897	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
608538001898	prephenate dehydrogenase; Validated; Region: PRK08507
608538001899	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
608538001900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538001901	dimer interface [polypeptide binding]; other site
608538001902	ABC-ATPase subunit interface; other site
608538001903	putative PBP binding loops; other site
608538001904	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
608538001905	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
608538001906	Bacterial sugar transferase; Region: Bac_transf; pfam02397
608538001907	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
608538001908	tetramerization interface [polypeptide binding]; other site
608538001909	active site
608538001910	D-allose kinase; Provisional; Region: PRK09698
608538001911	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
608538001912	nucleotide binding site [chemical binding]; other site
608538001913	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
608538001914	Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like; cd12825
608538001915	Cl binding site [ion binding]; other site
608538001916	oligomer interface [polypeptide binding]; other site
608538001917	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
608538001918	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538001919	Maf-like protein; Region: Maf; pfam02545
608538001920	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
608538001921	active site
608538001922	dimer interface [polypeptide binding]; other site
608538001923	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
608538001924	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
608538001925	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538001926	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
608538001927	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538001928	magnesium-transporting ATPase; Provisional; Region: PRK15122
608538001929	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
608538001930	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538001931	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538001932	Soluble P-type ATPase [General function prediction only]; Region: COG4087
608538001933	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538001934	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
608538001935	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538001936	CPxP  motif; other site
608538001937	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
608538001938	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK01236
608538001939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538001940	S-adenosylmethionine binding site [chemical binding]; other site
608538001941	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
608538001942	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
608538001943	active site
608538001944	(T/H)XGH motif; other site
608538001945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538001946	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
608538001947	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538001948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538001949	active site
608538001950	phosphorylation site [posttranslational modification]
608538001951	intermolecular recognition site; other site
608538001952	dimerization interface [polypeptide binding]; other site
608538001953	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538001954	DNA binding site [nucleotide binding]
608538001955	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
608538001956	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538001957	active site
608538001958	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
608538001959	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
608538001960	substrate binding site [chemical binding]; other site
608538001961	ribosome recycling factor; Reviewed; Region: frr; PRK00083
608538001962	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
608538001963	hinge region; other site
608538001964	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
608538001965	putative nucleotide binding site [chemical binding]; other site
608538001966	uridine monophosphate binding site [chemical binding]; other site
608538001967	homohexameric interface [polypeptide binding]; other site
608538001968	elongation factor Ts; Provisional; Region: tsf; PRK09377
608538001969	UBA/TS-N domain; Region: UBA; pfam00627
608538001970	putative protein-protein interaction site; other site
608538001971	GFP-loop; other site
608538001972	Elongation factor TS; Region: EF_TS; pfam00889
608538001973	Elongation factor TS; Region: EF_TS; pfam00889
608538001974	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
608538001975	rRNA interaction site [nucleotide binding]; other site
608538001976	S8 interaction site; other site
608538001977	putative laminin-1 binding site; other site
608538001978	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
608538001979	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
608538001980	dimerization interface [polypeptide binding]; other site
608538001981	domain crossover interface; other site
608538001982	redox-dependent activation switch; other site
608538001983	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
608538001984	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
608538001985	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
608538001986	UbiA prenyltransferase family; Region: UbiA; pfam01040
608538001987	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538001988	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
608538001989	nucleoside/Zn binding site; other site
608538001990	dimer interface [polypeptide binding]; other site
608538001991	catalytic motif [active]
608538001992	lipoyl synthase; Provisional; Region: PRK12928
608538001993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538001994	FeS/SAM binding site; other site
608538001995	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
608538001996	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
608538001997	Substrate binding site; other site
608538001998	Cupin domain; Region: Cupin_2; cl17218
608538001999	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
608538002000	active site
608538002001	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
608538002002	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
608538002003	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
608538002004	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538002005	RNA binding surface [nucleotide binding]; other site
608538002006	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
608538002007	active site
608538002008	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
608538002009	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
608538002010	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
608538002011	Walker A/P-loop; other site
608538002012	ATP binding site [chemical binding]; other site
608538002013	Q-loop/lid; other site
608538002014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
608538002015	ABC transporter signature motif; other site
608538002016	Walker B; other site
608538002017	D-loop; other site
608538002018	H-loop/switch region; other site
608538002019	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
608538002020	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
608538002021	active site
608538002022	metal binding site [ion binding]; metal-binding site
608538002023	DNA binding site [nucleotide binding]
608538002024	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
608538002025	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
608538002026	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
608538002027	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
608538002028	RNA binding site [nucleotide binding]; other site
608538002029	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
608538002030	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
608538002031	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
608538002032	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
608538002033	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
608538002034	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
608538002035	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
608538002036	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
608538002037	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
608538002038	23S rRNA interface [nucleotide binding]; other site
608538002039	5S rRNA interface [nucleotide binding]; other site
608538002040	L27 interface [polypeptide binding]; other site
608538002041	L5 interface [polypeptide binding]; other site
608538002042	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
608538002043	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
608538002044	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
608538002045	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
608538002046	23S rRNA binding site [nucleotide binding]; other site
608538002047	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
608538002048	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
608538002049	SecY translocase; Region: SecY; pfam00344
608538002050	adenylate kinase; Reviewed; Region: adk; PRK00279
608538002051	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
608538002052	AMP-binding site [chemical binding]; other site
608538002053	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
608538002054	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
608538002055	active site
608538002056	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
608538002057	rRNA binding site [nucleotide binding]; other site
608538002058	predicted 30S ribosome binding site; other site
608538002059	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
608538002060	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
608538002061	30S ribosomal protein S13; Region: bact_S13; TIGR03631
608538002062	30S ribosomal protein S11; Validated; Region: PRK05309
608538002063	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
608538002064	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
608538002065	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538002066	RNA binding surface [nucleotide binding]; other site
608538002067	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
608538002068	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
608538002069	alphaNTD homodimer interface [polypeptide binding]; other site
608538002070	alphaNTD - beta interaction site [polypeptide binding]; other site
608538002071	alphaNTD - beta' interaction site [polypeptide binding]; other site
608538002072	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
608538002073	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
608538002074	YGGT family; Region: YGGT; pfam02325
608538002075	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
608538002076	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538002077	RNA binding surface [nucleotide binding]; other site
608538002078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002079	S-adenosylmethionine binding site [chemical binding]; other site
608538002080	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
608538002081	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
608538002082	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
608538002083	Catalytic site [active]
608538002084	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
608538002085	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14467
608538002086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002087	FeS/SAM binding site; other site
608538002088	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538002089	MoaE interaction surface [polypeptide binding]; other site
608538002090	MoeB interaction surface [polypeptide binding]; other site
608538002091	thiocarboxylated glycine; other site
608538002092	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538002093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002094	S-adenosylmethionine binding site [chemical binding]; other site
608538002095	excinuclease ABC subunit B; Provisional; Region: PRK05298
608538002096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538002097	ATP binding site [chemical binding]; other site
608538002098	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
608538002099	putative Mg++ binding site [ion binding]; other site
608538002100	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538002101	nucleotide binding region [chemical binding]; other site
608538002102	ATP-binding site [chemical binding]; other site
608538002103	Ultra-violet resistance protein B; Region: UvrB; pfam12344
608538002104	UvrB/uvrC motif; Region: UVR; pfam02151
608538002105	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
608538002106	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538002107	minor groove reading motif; other site
608538002108	helix-hairpin-helix signature motif; other site
608538002109	substrate binding pocket [chemical binding]; other site
608538002110	active site
608538002111	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
608538002112	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
608538002113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002114	S-adenosylmethionine binding site [chemical binding]; other site
608538002115	spermidine synthase; Provisional; Region: PRK00811
608538002116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002117	S-adenosylmethionine binding site [chemical binding]; other site
608538002118	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
608538002119	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
608538002120	active site
608538002121	HIGH motif; other site
608538002122	KMSKS motif; other site
608538002123	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
608538002124	anticodon binding site; other site
608538002125	tRNA binding surface [nucleotide binding]; other site
608538002126	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
608538002127	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538002128	metal binding triad; other site
608538002129	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
608538002130	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538002131	metal binding triad; other site
608538002132	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
608538002133	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
608538002134	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
608538002135	putative metal binding site; other site
608538002136	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
608538002137	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
608538002138	poxB regulator PoxA; Provisional; Region: PRK09350
608538002139	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
608538002140	motif 1; other site
608538002141	dimer interface [polypeptide binding]; other site
608538002142	active site
608538002143	motif 2; other site
608538002144	motif 3; other site
608538002145	nickel responsive regulator; Provisional; Region: PRK00630
608538002146	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
608538002147	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
608538002148	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
608538002149	dimer interface [polypeptide binding]; other site
608538002150	catalytic triad [active]
608538002151	peroxidatic and resolving cysteines [active]
608538002152	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
608538002153	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
608538002154	active site
608538002155	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538002156	dimer interface [polypeptide binding]; other site
608538002157	substrate binding site [chemical binding]; other site
608538002158	catalytic residues [active]
608538002159	aconitate hydratase; Validated; Region: PRK07229
608538002160	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
608538002161	substrate binding site [chemical binding]; other site
608538002162	ligand binding site [chemical binding]; other site
608538002163	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
608538002164	substrate binding site [chemical binding]; other site
608538002165	malate dehydrogenase; Reviewed; Region: PRK06223
608538002166	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
608538002167	NAD(P) binding site [chemical binding]; other site
608538002168	dimer interface [polypeptide binding]; other site
608538002169	tetramer (dimer of dimers) interface [polypeptide binding]; other site
608538002170	substrate binding site [chemical binding]; other site
608538002171	fumarate hydratase; Provisional; Region: PRK06246
608538002172	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
608538002173	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
608538002174	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
608538002175	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538002176	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
608538002177	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
608538002178	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
608538002179	active site
608538002180	homotetramer interface [polypeptide binding]; other site
608538002181	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
608538002182	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
608538002183	Active_site [active]
608538002184	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
608538002185	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002186	FeS/SAM binding site; other site
608538002187	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
608538002188	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
608538002189	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
608538002190	trimer interface [polypeptide binding]; other site
608538002191	active site
608538002192	UDP-GlcNAc binding site [chemical binding]; other site
608538002193	lipid binding site [chemical binding]; lipid-binding site
608538002194	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
608538002195	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
608538002196	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
608538002197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002198	Walker A motif; other site
608538002199	ATP binding site [chemical binding]; other site
608538002200	Walker B motif; other site
608538002201	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
608538002202	Clp protease; Region: CLP_protease; pfam00574
608538002203	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
608538002204	oligomer interface [polypeptide binding]; other site
608538002205	active site residues [active]
608538002206	trigger factor; Region: tig; TIGR00115
608538002207	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
608538002208	anthranilate synthase component I; Provisional; Region: PRK13565
608538002209	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
608538002210	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
608538002211	N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338
608538002212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002213	S-adenosylmethionine binding site [chemical binding]; other site
608538002214	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
608538002215	substrate binding site [chemical binding]; other site
608538002216	active site
608538002217	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538002218	phosphoglycolate phosphatase; Provisional; Region: PRK13222
608538002219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538002220	motif II; other site
608538002221	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
608538002222	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
608538002223	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
608538002224	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
608538002225	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
608538002226	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
608538002227	Zn2+ binding site [ion binding]; other site
608538002228	Mg2+ binding site [ion binding]; other site
608538002229	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
608538002230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
608538002231	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
608538002232	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
608538002233	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
608538002234	dimerization interface [polypeptide binding]; other site
608538002235	ATP binding site [chemical binding]; other site
608538002236	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
608538002237	dimerization interface [polypeptide binding]; other site
608538002238	ATP binding site [chemical binding]; other site
608538002239	lipoprotein signal peptidase; Provisional; Region: PRK14779
608538002240	lipoprotein signal peptidase; Provisional; Region: PRK14787
608538002241	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
608538002242	recombinase A; Provisional; Region: recA; PRK09354
608538002243	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
608538002244	hexamer interface [polypeptide binding]; other site
608538002245	Walker A motif; other site
608538002246	ATP binding site [chemical binding]; other site
608538002247	Walker B motif; other site
608538002248	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
608538002249	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
608538002250	Walker A motif; other site
608538002251	ATP binding site [chemical binding]; other site
608538002252	Walker B motif; other site
608538002253	cytidylate kinase; Provisional; Region: cmk; PRK00023
608538002254	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
608538002255	CMP-binding site; other site
608538002256	The sites determining sugar specificity; other site
608538002257	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
608538002258	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
608538002259	NAD(P) binding site [chemical binding]; other site
608538002260	catalytic residues [active]
608538002261	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
608538002262	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
608538002263	DNA binding residues [nucleotide binding]
608538002264	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
608538002265	thiamine phosphate binding site [chemical binding]; other site
608538002266	active site
608538002267	pyrophosphate binding site [ion binding]; other site
608538002268	5'-3' exonuclease; Region: 53EXOc; smart00475
608538002269	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
608538002270	active site
608538002271	metal binding site 1 [ion binding]; metal-binding site
608538002272	putative 5' ssDNA interaction site; other site
608538002273	metal binding site 3; metal-binding site
608538002274	metal binding site 2 [ion binding]; metal-binding site
608538002275	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
608538002276	putative DNA binding site [nucleotide binding]; other site
608538002277	putative metal binding site [ion binding]; other site
608538002278	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
608538002279	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
608538002280	active site
608538002281	NTP binding site [chemical binding]; other site
608538002282	metal binding triad [ion binding]; metal-binding site
608538002283	antibiotic binding site [chemical binding]; other site
608538002284	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
608538002285	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
608538002286	dimer interface [polypeptide binding]; other site
608538002287	active site residues [active]
608538002288	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
608538002289	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
608538002290	putative phosphate acyltransferase; Provisional; Region: PRK05331
608538002291	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
608538002292	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
608538002293	dimer interface [polypeptide binding]; other site
608538002294	active site
608538002295	CoA binding pocket [chemical binding]; other site
608538002296	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
608538002297	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
608538002298	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538002299	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538002300	Soluble P-type ATPase [General function prediction only]; Region: COG4087
608538002301	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538002302	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
608538002303	DEAD-like helicases superfamily; Region: DEXDc; smart00487
608538002304	ATP binding site [chemical binding]; other site
608538002305	Mg++ binding site [ion binding]; other site
608538002306	motif III; other site
608538002307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538002308	nucleotide binding region [chemical binding]; other site
608538002309	ATP-binding site [chemical binding]; other site
608538002310	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
608538002311	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
608538002312	sulfite oxidase; Provisional; Region: PLN00177
608538002313	Moco binding site; other site
608538002314	metal coordination site [ion binding]; other site
608538002315	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
608538002316	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
608538002317	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538002318	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
608538002319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538002320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
608538002321	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
608538002322	intersubunit interface [polypeptide binding]; other site
608538002323	active site
608538002324	catalytic residue [active]
608538002325	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538002326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538002327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538002328	2-isopropylmalate synthase; Validated; Region: PRK00915
608538002329	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
608538002330	active site
608538002331	catalytic residues [active]
608538002332	metal binding site [ion binding]; metal-binding site
608538002333	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
608538002334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
608538002335	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
608538002336	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002337	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
608538002338	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
608538002339	iron-sulfur cluster [ion binding]; other site
608538002340	[2Fe-2S] cluster binding site [ion binding]; other site
608538002341	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
608538002342	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538002343	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002344	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
608538002345	thiamine phosphate binding site [chemical binding]; other site
608538002346	active site
608538002347	pyrophosphate binding site [ion binding]; other site
608538002348	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
608538002349	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
608538002350	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
608538002351	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
608538002352	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
608538002353	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
608538002354	putative NTPase; Provisional; Region: PRK13695
608538002355	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
608538002356	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538002357	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
608538002358	ATP-grasp domain; Region: ATP-grasp_4; cl17255
608538002359	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
608538002360	IMP binding site; other site
608538002361	dimer interface [polypeptide binding]; other site
608538002362	interdomain contacts; other site
608538002363	partial ornithine binding site; other site
608538002364	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002366	active site
608538002367	phosphorylation site [posttranslational modification]
608538002368	intermolecular recognition site; other site
608538002369	dimerization interface [polypeptide binding]; other site
608538002370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002371	Walker A motif; other site
608538002372	ATP binding site [chemical binding]; other site
608538002373	Walker B motif; other site
608538002374	arginine finger; other site
608538002375	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
608538002376	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
608538002377	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
608538002378	homodimer interface [polypeptide binding]; other site
608538002379	metal binding site [ion binding]; metal-binding site
608538002380	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
608538002381	homodimer interface [polypeptide binding]; other site
608538002382	active site
608538002383	putative chemical substrate binding site [chemical binding]; other site
608538002384	metal binding site [ion binding]; metal-binding site
608538002385	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
608538002386	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
608538002387	ATP binding site [chemical binding]; other site
608538002388	substrate interface [chemical binding]; other site
608538002389	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
608538002390	heterotetramer interface [polypeptide binding]; other site
608538002391	active site pocket [active]
608538002392	cleavage site
608538002393	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
608538002394	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
608538002395	dimerization interface [polypeptide binding]; other site
608538002396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538002397	putative active site [active]
608538002398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538002399	dimer interface [polypeptide binding]; other site
608538002400	phosphorylation site [posttranslational modification]
608538002401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002402	ATP binding site [chemical binding]; other site
608538002403	Mg2+ binding site [ion binding]; other site
608538002404	G-X-G motif; other site
608538002405	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
608538002406	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
608538002407	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
608538002408	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
608538002409	DNA gyrase subunit A; Validated; Region: PRK05560
608538002410	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
608538002411	CAP-like domain; other site
608538002412	active site
608538002413	primary dimer interface [polypeptide binding]; other site
608538002414	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002415	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002416	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
608538002417	Competence protein; Region: Competence; pfam03772
608538002418	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
608538002419	DEAD/DEAH box helicase; Region: DEAD; pfam00270
608538002420	ATP binding site [chemical binding]; other site
608538002421	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
608538002422	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
608538002423	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
608538002424	Walker A/P-loop; other site
608538002425	ATP binding site [chemical binding]; other site
608538002426	Q-loop/lid; other site
608538002427	ABC transporter signature motif; other site
608538002428	Walker B; other site
608538002429	D-loop; other site
608538002430	H-loop/switch region; other site
608538002431	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
608538002432	putative carbohydrate binding site [chemical binding]; other site
608538002433	isocitrate dehydrogenase; Validated; Region: PRK06451
608538002434	Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538
608538002435	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
608538002436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538002437	S-adenosylmethionine binding site [chemical binding]; other site
608538002438	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
608538002439	AP endonuclease family 2; Region: AP2Ec; smart00518
608538002440	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
608538002441	AP (apurinic/apyrimidinic) site pocket; other site
608538002442	DNA interaction; other site
608538002443	Metal-binding active site; metal-binding site
608538002444	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
608538002445	DHH family; Region: DHH; pfam01368
608538002446	DHHA1 domain; Region: DHHA1; pfam02272
608538002447	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
608538002448	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
608538002449	HIGH motif; other site
608538002450	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
608538002451	active site
608538002452	KMSKS motif; other site
608538002453	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
608538002454	tRNA binding surface [nucleotide binding]; other site
608538002455	anticodon binding site; other site
608538002456	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
608538002457	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
608538002458	50S ribosomal protein L29; Reviewed; Region: PRK00306
608538002459	putative translocon interaction site; other site
608538002460	23S rRNA interface [nucleotide binding]; other site
608538002461	signal recognition particle (SRP54) interaction site; other site
608538002462	L23 interface [polypeptide binding]; other site
608538002463	trigger factor interaction site; other site
608538002464	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
608538002465	23S rRNA interface [nucleotide binding]; other site
608538002466	5S rRNA interface [nucleotide binding]; other site
608538002467	putative antibiotic binding site [chemical binding]; other site
608538002468	L25 interface [polypeptide binding]; other site
608538002469	L27 interface [polypeptide binding]; other site
608538002470	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
608538002471	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
608538002472	G-X-X-G motif; other site
608538002473	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
608538002474	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
608538002475	putative translocon binding site; other site
608538002476	protein-rRNA interface [nucleotide binding]; other site
608538002477	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
608538002478	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
608538002479	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
608538002480	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
608538002481	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
608538002482	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
608538002483	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
608538002484	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
608538002485	elongation factor Tu; Reviewed; Region: PRK00049
608538002486	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
608538002487	G1 box; other site
608538002488	GEF interaction site [polypeptide binding]; other site
608538002489	GTP/Mg2+ binding site [chemical binding]; other site
608538002490	Switch I region; other site
608538002491	G2 box; other site
608538002492	G3 box; other site
608538002493	Switch II region; other site
608538002494	G4 box; other site
608538002495	G5 box; other site
608538002496	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
608538002497	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
608538002498	Antibiotic Binding Site [chemical binding]; other site
608538002499	elongation factor G; Reviewed; Region: PRK00007
608538002500	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
608538002501	G1 box; other site
608538002502	putative GEF interaction site [polypeptide binding]; other site
608538002503	GTP/Mg2+ binding site [chemical binding]; other site
608538002504	Switch I region; other site
608538002505	G2 box; other site
608538002506	G3 box; other site
608538002507	Switch II region; other site
608538002508	G4 box; other site
608538002509	G5 box; other site
608538002510	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
608538002511	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
608538002512	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
608538002513	30S ribosomal protein S7; Validated; Region: PRK05302
608538002514	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
608538002515	S17 interaction site [polypeptide binding]; other site
608538002516	S8 interaction site; other site
608538002517	16S rRNA interaction site [nucleotide binding]; other site
608538002518	streptomycin interaction site [chemical binding]; other site
608538002519	23S rRNA interaction site [nucleotide binding]; other site
608538002520	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
608538002521	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
608538002522	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
608538002523	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
608538002524	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
608538002525	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
608538002526	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
608538002527	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
608538002528	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
608538002529	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
608538002530	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
608538002531	DNA binding site [nucleotide binding]
608538002532	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
608538002533	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
608538002534	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
608538002535	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
608538002536	RPB12 interaction site [polypeptide binding]; other site
608538002537	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
608538002538	RPB11 interaction site [polypeptide binding]; other site
608538002539	RPB12 interaction site [polypeptide binding]; other site
608538002540	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
608538002541	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
608538002542	RPB1 interaction site [polypeptide binding]; other site
608538002543	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
608538002544	core dimer interface [polypeptide binding]; other site
608538002545	peripheral dimer interface [polypeptide binding]; other site
608538002546	L10 interface [polypeptide binding]; other site
608538002547	L11 interface [polypeptide binding]; other site
608538002548	putative EF-Tu interaction site [polypeptide binding]; other site
608538002549	putative EF-G interaction site [polypeptide binding]; other site
608538002550	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
608538002551	23S rRNA interface [nucleotide binding]; other site
608538002552	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
608538002553	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
608538002554	mRNA/rRNA interface [nucleotide binding]; other site
608538002555	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
608538002556	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
608538002557	23S rRNA interface [nucleotide binding]; other site
608538002558	L7/L12 interface [polypeptide binding]; other site
608538002559	putative thiostrepton binding site; other site
608538002560	L25 interface [polypeptide binding]; other site
608538002561	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
608538002562	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
608538002563	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
608538002564	putative homodimer interface [polypeptide binding]; other site
608538002565	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
608538002566	heterodimer interface [polypeptide binding]; other site
608538002567	homodimer interface [polypeptide binding]; other site
608538002568	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
608538002569	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
608538002570	elongation factor Tu; Reviewed; Region: PRK00049
608538002571	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
608538002572	G1 box; other site
608538002573	GEF interaction site [polypeptide binding]; other site
608538002574	GTP/Mg2+ binding site [chemical binding]; other site
608538002575	Switch I region; other site
608538002576	G2 box; other site
608538002577	G3 box; other site
608538002578	Switch II region; other site
608538002579	G4 box; other site
608538002580	G5 box; other site
608538002581	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
608538002582	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
608538002583	Antibiotic Binding Site [chemical binding]; other site
608538002584	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
608538002585	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
608538002586	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
608538002587	active site
608538002588	dimer interface [polypeptide binding]; other site
608538002589	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
608538002590	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
608538002591	active site
608538002592	FMN binding site [chemical binding]; other site
608538002593	substrate binding site [chemical binding]; other site
608538002594	3Fe-4S cluster binding site [ion binding]; other site
608538002595	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
608538002596	domain interface; other site
608538002597	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
608538002598	active site
608538002599	dimer interface [polypeptide binding]; other site
608538002600	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
608538002601	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
608538002602	putative active site [active]
608538002603	oxyanion strand; other site
608538002604	catalytic triad [active]
608538002605	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
608538002606	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
608538002607	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538002608	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
608538002609	catalytic residues [active]
608538002610	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538002611	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538002612	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
608538002613	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
608538002614	DNA binding residues [nucleotide binding]
608538002615	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
608538002616	catalytic residues [active]
608538002617	catalytic nucleophile [active]
608538002618	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
608538002619	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
608538002620	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
608538002621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
608538002622	Terminase-like family; Region: Terminase_6; pfam03237
608538002623	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
608538002624	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
608538002625	cell surface protein SprA; Region: surface_SprA; TIGR04189
608538002626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538002627	non-specific DNA binding site [nucleotide binding]; other site
608538002628	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
608538002629	salt bridge; other site
608538002630	sequence-specific DNA binding site [nucleotide binding]; other site
608538002631	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
608538002632	Catalytic site [active]
608538002633	ParB-like nuclease domain; Region: ParB; smart00470
608538002634	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538002635	sequence-specific DNA binding site [nucleotide binding]; other site
608538002636	salt bridge; other site
608538002637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
608538002638	Homeodomain-like domain; Region: HTH_23; pfam13384
608538002639	Integrase core domain; Region: rve; pfam00665
608538002640	AAA domain; Region: AAA_22; pfam13401
608538002641	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
608538002642	Helix-turn-helix domain; Region: HTH_17; pfam12728
608538002643	Phage capsid family; Region: Phage_capsid; pfam05065
608538002644	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
608538002645	hypothetical protein; Region: PHA01756
608538002646	GAF domain; Region: GAF_2; pfam13185
608538002647	GAF domain; Region: GAF; pfam01590
608538002648	PAS domain; Region: PAS_9; pfam13426
608538002649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538002650	putative active site [active]
608538002651	heme pocket [chemical binding]; other site
608538002652	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
608538002653	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538002654	metal binding site [ion binding]; metal-binding site
608538002655	active site
608538002656	I-site; other site
608538002657	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
608538002658	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
608538002659	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
608538002660	[4Fe-4S] binding site [ion binding]; other site
608538002661	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538002662	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538002663	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
608538002664	molybdopterin cofactor binding site; other site
608538002665	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
608538002666	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
608538002667	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
608538002668	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
608538002669	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
608538002670	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
608538002671	E-class dimer interface [polypeptide binding]; other site
608538002672	P-class dimer interface [polypeptide binding]; other site
608538002673	active site
608538002674	Cu2+ binding site [ion binding]; other site
608538002675	Zn2+ binding site [ion binding]; other site
608538002676	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
608538002677	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
608538002678	glycine cleavage system protein H; Provisional; Region: PRK13380
608538002679	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538002680	lipoyl attachment site [posttranslational modification]; other site
608538002681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
608538002682	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
608538002683	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
608538002684	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
608538002685	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002686	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
608538002687	FtsX-like permease family; Region: FtsX; pfam02687
608538002688	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002689	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
608538002690	Walker A/P-loop; other site
608538002691	ATP binding site [chemical binding]; other site
608538002692	Q-loop/lid; other site
608538002693	ABC transporter signature motif; other site
608538002694	Walker B; other site
608538002695	D-loop; other site
608538002696	H-loop/switch region; other site
608538002697	macrolide transporter subunit MacA; Provisional; Region: PRK11578
608538002698	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538002699	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
608538002700	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538002701	putative membrane fusion protein; Region: TIGR02828
608538002702	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
608538002703	active site
608538002704	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
608538002705	active site
608538002706	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
608538002707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538002708	FeS/SAM binding site; other site
608538002709	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
608538002710	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
608538002711	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
608538002712	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
608538002713	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
608538002714	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538002715	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
608538002716	Subunit I/III interface [polypeptide binding]; other site
608538002717	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
608538002718	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
608538002719	ligand binding site [chemical binding]; other site
608538002720	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
608538002721	putative active site [active]
608538002722	dimerization interface [polypeptide binding]; other site
608538002723	putative tRNAtyr binding site [nucleotide binding]; other site
608538002724	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
608538002725	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
608538002726	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
608538002727	cysteine synthase B; Region: cysM; TIGR01138
608538002728	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
608538002729	dimer interface [polypeptide binding]; other site
608538002730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002731	catalytic residue [active]
608538002732	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
608538002733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538002734	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538002735	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
608538002736	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538002737	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538002738	putative active site [active]
608538002739	MraW methylase family; Region: Methyltransf_5; pfam01795
608538002740	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
608538002741	ATP synthase; Region: ATP-synt; pfam00231
608538002742	core domain interface [polypeptide binding]; other site
608538002743	delta subunit interface [polypeptide binding]; other site
608538002744	epsilon subunit interface [polypeptide binding]; other site
608538002745	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
608538002746	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
608538002747	active site
608538002748	HIGH motif; other site
608538002749	dimer interface [polypeptide binding]; other site
608538002750	KMSKS motif; other site
608538002751	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
608538002752	trimer interface [polypeptide binding]; other site
608538002753	active site
608538002754	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
608538002755	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002756	FtsX-like permease family; Region: FtsX; pfam02687
608538002757	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002758	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
608538002759	Walker A/P-loop; other site
608538002760	ATP binding site [chemical binding]; other site
608538002761	Q-loop/lid; other site
608538002762	ABC transporter signature motif; other site
608538002763	Walker B; other site
608538002764	D-loop; other site
608538002765	H-loop/switch region; other site
608538002766	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
608538002767	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
608538002768	Ligand binding site; other site
608538002769	Putative Catalytic site; other site
608538002770	DXD motif; other site
608538002771	Protein of unknown function (DUF523); Region: DUF523; pfam04463
608538002772	Uncharacterized conserved protein [Function unknown]; Region: COG3272
608538002773	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
608538002774	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
608538002775	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
608538002776	CoA-binding site [chemical binding]; other site
608538002777	ATP-binding [chemical binding]; other site
608538002778	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
608538002779	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538002780	Cysteine-rich domain; Region: CCG; pfam02754
608538002781	Cysteine-rich domain; Region: CCG; pfam02754
608538002782	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
608538002783	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538002784	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
608538002785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
608538002786	PAS domain; Region: PAS_9; pfam13426
608538002787	putative active site [active]
608538002788	heme pocket [chemical binding]; other site
608538002789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538002790	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
608538002791	dimer interface [polypeptide binding]; other site
608538002792	phosphorylation site [posttranslational modification]
608538002793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002794	ATP binding site [chemical binding]; other site
608538002795	Mg2+ binding site [ion binding]; other site
608538002796	G-X-G motif; other site
608538002797	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002799	active site
608538002800	phosphorylation site [posttranslational modification]
608538002801	intermolecular recognition site; other site
608538002802	dimerization interface [polypeptide binding]; other site
608538002803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002804	Walker A motif; other site
608538002805	ATP binding site [chemical binding]; other site
608538002806	Walker B motif; other site
608538002807	arginine finger; other site
608538002808	GTPase Era; Reviewed; Region: era; PRK00089
608538002809	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
608538002810	G1 box; other site
608538002811	GTP/Mg2+ binding site [chemical binding]; other site
608538002812	Switch I region; other site
608538002813	G2 box; other site
608538002814	Switch II region; other site
608538002815	G3 box; other site
608538002816	G4 box; other site
608538002817	G5 box; other site
608538002818	KH domain; Region: KH_2; pfam07650
608538002819	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
608538002820	DNA methylase; Region: N6_N4_Mtase; pfam01555
608538002821	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
608538002822	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
608538002823	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
608538002824	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
608538002825	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
608538002826	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
608538002827	MPT binding site; other site
608538002828	trimer interface [polypeptide binding]; other site
608538002829	enolase; Provisional; Region: eno; PRK00077
608538002830	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
608538002831	dimer interface [polypeptide binding]; other site
608538002832	metal binding site [ion binding]; metal-binding site
608538002833	substrate binding pocket [chemical binding]; other site
608538002834	Septum formation initiator; Region: DivIC; cl17659
608538002835	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
608538002836	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
608538002837	catalytic motif [active]
608538002838	Zn binding site [ion binding]; other site
608538002839	RibD C-terminal domain; Region: RibD_C; cl17279
608538002840	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
608538002841	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
608538002842	putative active site [active]
608538002843	substrate binding site [chemical binding]; other site
608538002844	putative cosubstrate binding site; other site
608538002845	catalytic site [active]
608538002846	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
608538002847	substrate binding site [chemical binding]; other site
608538002848	Uncharacterized conserved protein [Function unknown]; Region: COG2445
608538002849	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
608538002850	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538002851	catalytic loop [active]
608538002852	iron binding site [ion binding]; other site
608538002853	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
608538002854	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
608538002855	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
608538002856	RimM N-terminal domain; Region: RimM; pfam01782
608538002857	PRC-barrel domain; Region: PRC; pfam05239
608538002858	Cytochrome c; Region: Cytochrom_C; cl11414
608538002859	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
608538002860	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
608538002861	Peptidase family M48; Region: Peptidase_M48; pfam01435
608538002862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538002863	TPR repeat; Region: TPR_11; pfam13414
608538002864	TPR motif; other site
608538002865	binding surface
608538002866	Tetratricopeptide repeat; Region: TPR_12; pfam13424
608538002867	Protein phosphatase 2C; Region: PP2C; pfam00481
608538002868	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
608538002869	active site
608538002870	KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878
608538002871	KaiC; Region: KaiC; pfam06745
608538002872	Walker A motif; other site
608538002873	ATP binding site [chemical binding]; other site
608538002874	Walker B motif; other site
608538002875	NlpC/P60 family; Region: NLPC_P60; pfam00877
608538002876	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
608538002877	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
608538002878	active site residue [active]
608538002879	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
608538002880	active site
608538002881	DsrE/DsrF-like family; Region: DrsE; pfam02635
608538002882	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
608538002883	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
608538002884	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
608538002885	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538002886	catalytic residue [active]
608538002887	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
608538002888	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538002889	inhibitor-cofactor binding pocket; inhibition site
608538002890	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002891	catalytic residue [active]
608538002892	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
608538002893	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
608538002894	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
608538002895	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
608538002896	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538002897	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
608538002898	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
608538002899	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
608538002900	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
608538002901	dimerization interface [polypeptide binding]; other site
608538002902	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
608538002903	ATP binding site [chemical binding]; other site
608538002904	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
608538002905	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
608538002906	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
608538002907	Acylphosphatase; Region: Acylphosphatase; pfam00708
608538002908	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
608538002909	HypF finger; Region: zf-HYPF; pfam07503
608538002910	HypF finger; Region: zf-HYPF; pfam07503
608538002911	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
608538002912	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
608538002913	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538002914	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
608538002915	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
608538002916	putative substrate-binding site; other site
608538002917	nickel binding site [ion binding]; other site
608538002918	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
608538002919	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
608538002920	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
608538002921	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
608538002922	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
608538002923	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
608538002924	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
608538002925	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
608538002926	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
608538002927	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538002928	IHF dimer interface [polypeptide binding]; other site
608538002929	IHF - DNA interface [nucleotide binding]; other site
608538002930	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
608538002931	ribosomal protein S1; Region: rpsA; TIGR00717
608538002932	RNA binding site [nucleotide binding]; other site
608538002933	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
608538002934	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
608538002935	S1 RNA binding domain; Region: S1; pfam00575
608538002936	RNA binding site [nucleotide binding]; other site
608538002937	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
608538002938	RNA binding site [nucleotide binding]; other site
608538002939	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
608538002940	RNA binding site [nucleotide binding]; other site
608538002941	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
608538002942	hypothetical protein; Reviewed; Region: PRK09588
608538002943	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
608538002944	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002945	FtsX-like permease family; Region: FtsX; pfam02687
608538002946	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002947	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
608538002948	Walker A/P-loop; other site
608538002949	ATP binding site [chemical binding]; other site
608538002950	Q-loop/lid; other site
608538002951	ABC transporter signature motif; other site
608538002952	Walker B; other site
608538002953	D-loop; other site
608538002954	H-loop/switch region; other site
608538002955	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002956	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538002957	FtsX-like permease family; Region: FtsX; pfam02687
608538002958	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538002959	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
608538002960	Walker A/P-loop; other site
608538002961	ATP binding site [chemical binding]; other site
608538002962	Q-loop/lid; other site
608538002963	ABC transporter signature motif; other site
608538002964	Walker B; other site
608538002965	D-loop; other site
608538002966	H-loop/switch region; other site
608538002967	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
608538002968	YtkA-like; Region: YtkA; pfam13115
608538002969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538002970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538002971	ATP binding site [chemical binding]; other site
608538002972	Mg2+ binding site [ion binding]; other site
608538002973	G-X-G motif; other site
608538002974	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538002975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538002976	active site
608538002977	phosphorylation site [posttranslational modification]
608538002978	intermolecular recognition site; other site
608538002979	dimerization interface [polypeptide binding]; other site
608538002980	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538002981	Walker A motif; other site
608538002982	ATP binding site [chemical binding]; other site
608538002983	Walker B motif; other site
608538002984	arginine finger; other site
608538002985	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
608538002986	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
608538002987	active site
608538002988	catalytic residues [active]
608538002989	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
608538002990	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
608538002991	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
608538002992	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
608538002993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538002994	catalytic residue [active]
608538002995	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
608538002996	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
608538002997	active site
608538002998	DsrH like protein; Region: DsrH; cl17347
608538002999	DsrE/DsrF-like family; Region: DrsE; cl00672
608538003000	DsrE/DsrF-like family; Region: DrsE; pfam02635
608538003001	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538003002	CPxP  motif; other site
608538003003	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
608538003004	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
608538003005	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538003006	Walker A motif; other site
608538003007	ATP binding site [chemical binding]; other site
608538003008	Walker B motif; other site
608538003009	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
608538003010	oligomerization interface [polypeptide binding]; other site
608538003011	active site
608538003012	metal binding site [ion binding]; metal-binding site
608538003013	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
608538003014	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
608538003015	HIGH motif; other site
608538003016	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
608538003017	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538003018	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538003019	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
608538003020	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
608538003021	nucleotide binding site [chemical binding]; other site
608538003022	NEF interaction site [polypeptide binding]; other site
608538003023	SBD interface [polypeptide binding]; other site
608538003024	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
608538003025	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
608538003026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538003027	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
608538003028	putative ADP-binding pocket [chemical binding]; other site
608538003029	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538003030	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
608538003031	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
608538003032	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
608538003033	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
608538003034	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
608538003035	active site
608538003036	HIGH motif; other site
608538003037	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
608538003038	KMSKS motif; other site
608538003039	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
608538003040	tRNA binding surface [nucleotide binding]; other site
608538003041	anticodon binding site; other site
608538003042	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
608538003043	HIGH motif; other site
608538003044	dimer interface [polypeptide binding]; other site
608538003045	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
608538003046	active site
608538003047	KMSKS motif; other site
608538003048	PHP domain; Region: PHP; pfam02811
608538003049	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
608538003050	active site
608538003051	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
608538003052	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538003053	metal binding site [ion binding]; metal-binding site
608538003054	active site
608538003055	I-site; other site
608538003056	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
608538003057	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
608538003058	metal binding site [ion binding]; metal-binding site
608538003059	active site
608538003060	I-site; other site
608538003061	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
608538003062	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
608538003063	dimer interface [polypeptide binding]; other site
608538003064	FMN binding site [chemical binding]; other site
608538003065	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
608538003066	CoenzymeA binding site [chemical binding]; other site
608538003067	subunit interaction site [polypeptide binding]; other site
608538003068	PHB binding site; other site
608538003069	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538003070	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
608538003071	active site
608538003072	catalytic tetrad [active]
608538003073	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
608538003074	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
608538003075	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538003076	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
608538003077	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
608538003078	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538003079	catalytic loop [active]
608538003080	iron binding site [ion binding]; other site
608538003081	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
608538003082	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
608538003083	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
608538003084	active site
608538003085	FMN binding site [chemical binding]; other site
608538003086	substrate binding site [chemical binding]; other site
608538003087	homotetramer interface [polypeptide binding]; other site
608538003088	catalytic residue [active]
608538003089	Predicted transcriptional regulators [Transcription]; Region: COG1733
608538003090	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538003091	dimerization interface [polypeptide binding]; other site
608538003092	putative DNA binding site [nucleotide binding]; other site
608538003093	putative Zn2+ binding site [ion binding]; other site
608538003094	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
608538003095	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
608538003096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003097	catalytic residue [active]
608538003098	septum site-determining protein MinC; Region: minC; TIGR01222
608538003099	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
608538003100	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
608538003101	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
608538003102	P-loop; other site
608538003103	ADP binding residues [chemical binding]; other site
608538003104	Switch I; other site
608538003105	Switch II; other site
608538003106	Septum formation topological specificity factor MinE; Region: MinE; cl00538
608538003107	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
608538003108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538003109	motif II; other site
608538003110	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
608538003111	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
608538003112	putative active site [active]
608538003113	putative metal binding site [ion binding]; other site
608538003114	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
608538003115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538003116	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538003117	SurA N-terminal domain; Region: SurA_N; pfam09312
608538003118	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
608538003119	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
608538003120	FAD binding domain; Region: FAD_binding_4; pfam01565
608538003121	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
608538003122	Protein of unknown function (DUF507); Region: DUF507; cl01112
608538003123	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
608538003124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003125	S-adenosylmethionine binding site [chemical binding]; other site
608538003126	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
608538003127	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
608538003128	gamma subunit interface [polypeptide binding]; other site
608538003129	epsilon subunit interface [polypeptide binding]; other site
608538003130	LBP interface [polypeptide binding]; other site
608538003131	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
608538003132	intersubunit interface [polypeptide binding]; other site
608538003133	active site
608538003134	Zn2+ binding site [ion binding]; other site
608538003135	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
608538003136	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
608538003137	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
608538003138	substrate binding site [chemical binding]; other site
608538003139	THF binding site; other site
608538003140	zinc-binding site [ion binding]; other site
608538003141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538003142	dimer interface [polypeptide binding]; other site
608538003143	phosphorylation site [posttranslational modification]
608538003144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538003145	ATP binding site [chemical binding]; other site
608538003146	Mg2+ binding site [ion binding]; other site
608538003147	G-X-G motif; other site
608538003148	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
608538003149	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
608538003150	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
608538003151	dimerization interface [polypeptide binding]; other site
608538003152	active site
608538003153	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
608538003154	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
608538003155	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
608538003156	Walker A/P-loop; other site
608538003157	ATP binding site [chemical binding]; other site
608538003158	Q-loop/lid; other site
608538003159	ABC transporter signature motif; other site
608538003160	Walker B; other site
608538003161	D-loop; other site
608538003162	H-loop/switch region; other site
608538003163	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
608538003164	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
608538003165	GTP cyclohydrolase I; Provisional; Region: PLN03044
608538003166	active site
608538003167	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
608538003168	active site
608538003169	KMSKS motif; other site
608538003170	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
608538003171	tRNA binding surface [nucleotide binding]; other site
608538003172	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
608538003173	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538003174	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
608538003175	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
608538003176	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
608538003177	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
608538003178	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
608538003179	TPP-binding site [chemical binding]; other site
608538003180	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
608538003181	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
608538003182	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
608538003183	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538003184	dimer interface [polypeptide binding]; other site
608538003185	PYR/PP interface [polypeptide binding]; other site
608538003186	TPP binding site [chemical binding]; other site
608538003187	substrate binding site [chemical binding]; other site
608538003188	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
608538003189	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
608538003190	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538003191	dimer interface [polypeptide binding]; other site
608538003192	PYR/PP interface [polypeptide binding]; other site
608538003193	TPP binding site [chemical binding]; other site
608538003194	substrate binding site [chemical binding]; other site
608538003195	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538003196	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
608538003197	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
608538003198	TPP-binding site [chemical binding]; other site
608538003199	dimer interface [polypeptide binding]; other site
608538003200	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
608538003201	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
608538003202	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
608538003203	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
608538003204	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
608538003205	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538003206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
608538003207	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
608538003208	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
608538003209	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
608538003210	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538003211	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
608538003212	active site
608538003213	catalytic tetrad [active]
608538003214	succinate dehydrogenase and fumarate reductase iron-sulfur protein; Region: dhsB; TIGR00384
608538003215	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538003216	catalytic loop [active]
608538003217	iron binding site [ion binding]; other site
608538003218	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
608538003219	Ligand Binding Site [chemical binding]; other site
608538003220	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
608538003221	active site
608538003222	SAM binding site [chemical binding]; other site
608538003223	homodimer interface [polypeptide binding]; other site
608538003224	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
608538003225	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
608538003226	active site
608538003227	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
608538003228	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
608538003229	[4Fe-4S] binding site [ion binding]; other site
608538003230	molybdopterin cofactor binding site; other site
608538003231	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
608538003232	molybdopterin cofactor binding site; other site
608538003233	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
608538003234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538003235	putative substrate translocation pore; other site
608538003236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538003237	cyanate hydratase; Validated; Region: PRK02866
608538003238	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
608538003239	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
608538003240	oligomer interface [polypeptide binding]; other site
608538003241	active site
608538003242	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
608538003243	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003244	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
608538003245	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003246	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
608538003247	heme-binding site [chemical binding]; other site
608538003248	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
608538003249	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538003250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003251	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
608538003252	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538003253	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
608538003254	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003255	metal-binding site [ion binding]
608538003256	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
608538003257	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003258	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
608538003259	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538003260	NifT/FixU protein; Region: NifT; pfam06988
608538003261	4Fe-4S binding domain; Region: Fer4; cl02805
608538003262	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
608538003263	Nitrogen fixation protein NifW; Region: NifW; pfam03206
608538003264	NifZ domain; Region: NifZ; pfam04319
608538003265	TOBE domain; Region: TOBE; cl01440
608538003266	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538003267	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
608538003268	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538003269	Rop-like; Region: Rop-like; cl02247
608538003270	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
608538003271	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
608538003272	active site
608538003273	catalytic residues [active]
608538003274	metal binding site [ion binding]; metal-binding site
608538003275	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003276	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
608538003277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003278	catalytic residue [active]
608538003279	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
608538003280	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
608538003281	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
608538003282	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
608538003283	GAF domain; Region: GAF; pfam01590
608538003284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538003285	Walker A motif; other site
608538003286	ATP binding site [chemical binding]; other site
608538003287	Walker B motif; other site
608538003288	arginine finger; other site
608538003289	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
608538003290	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
608538003291	nitrogenase iron protein; Region: nifH; TIGR01287
608538003292	Nucleotide-binding sites [chemical binding]; other site
608538003293	Walker A motif; other site
608538003294	Switch I region of nucleotide binding site; other site
608538003295	Fe4S4 binding sites [ion binding]; other site
608538003296	Switch II region of nucleotide binding site; other site
608538003297	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
608538003298	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538003299	ligand binding site [chemical binding]; other site
608538003300	flexible hinge region; other site
608538003301	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
608538003302	putative switch regulator; other site
608538003303	non-specific DNA interactions [nucleotide binding]; other site
608538003304	DNA binding site [nucleotide binding]
608538003305	sequence specific DNA binding site [nucleotide binding]; other site
608538003306	putative cAMP binding site [chemical binding]; other site
608538003307	Protein of unknown function, DUF269; Region: DUF269; cl03973
608538003308	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538003309	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
608538003310	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003311	catalytic residue [active]
608538003312	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
608538003313	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
608538003314	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
608538003315	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
608538003316	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
608538003317	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
608538003318	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
608538003319	hydrogenase 4 subunit F; Validated; Region: PRK06458
608538003320	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538003321	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
608538003322	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
608538003323	hydrogenase 4 subunit B; Validated; Region: PRK06521
608538003324	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538003325	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
608538003326	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
608538003327	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
608538003328	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
608538003329	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
608538003330	catalytic center binding site [active]
608538003331	ATP binding site [chemical binding]; other site
608538003332	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
608538003333	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
608538003334	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
608538003335	catalytic residue [active]
608538003336	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
608538003337	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
608538003338	Walker A motif; other site
608538003339	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
608538003340	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
608538003341	Walker A motif; other site
608538003342	ATP binding site [chemical binding]; other site
608538003343	Walker B motif; other site
608538003344	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
608538003345	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
608538003346	dimer interface [polypeptide binding]; other site
608538003347	active site
608538003348	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
608538003349	catalytic residues [active]
608538003350	substrate binding site [chemical binding]; other site
608538003351	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
608538003352	Ligand Binding Site [chemical binding]; other site
608538003353	Protein of unknown function (DUF458); Region: DUF458; cl00861
608538003354	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
608538003355	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
608538003356	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
608538003357	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
608538003358	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
608538003359	dimerization interface [polypeptide binding]; other site
608538003360	putative ATP binding site [chemical binding]; other site
608538003361	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
608538003362	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538003363	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538003364	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538003365	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538003366	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
608538003367	Surface antigen; Region: Bac_surface_Ag; pfam01103
608538003368	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
608538003369	dimer interface [polypeptide binding]; other site
608538003370	substrate binding site [chemical binding]; other site
608538003371	ATP binding site [chemical binding]; other site
608538003372	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
608538003373	trimer interface [polypeptide binding]; other site
608538003374	dimer interface [polypeptide binding]; other site
608538003375	putative active site [active]
608538003376	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
608538003377	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
608538003378	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
608538003379	DNA protecting protein DprA; Region: dprA; TIGR00732
608538003380	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
608538003381	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
608538003382	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
608538003383	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
608538003384	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
608538003385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003386	FeS/SAM binding site; other site
608538003387	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
608538003388	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
608538003389	Cupin domain; Region: Cupin_2; pfam07883
608538003390	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
608538003391	trimer interface [polypeptide binding]; other site
608538003392	active site
608538003393	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
608538003394	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
608538003395	RNase E interface [polypeptide binding]; other site
608538003396	trimer interface [polypeptide binding]; other site
608538003397	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
608538003398	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
608538003399	RNase E interface [polypeptide binding]; other site
608538003400	trimer interface [polypeptide binding]; other site
608538003401	active site
608538003402	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
608538003403	putative nucleic acid binding region [nucleotide binding]; other site
608538003404	G-X-X-G motif; other site
608538003405	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
608538003406	RNA binding site [nucleotide binding]; other site
608538003407	domain interface; other site
608538003408	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
608538003409	16S/18S rRNA binding site [nucleotide binding]; other site
608538003410	S13e-L30e interaction site [polypeptide binding]; other site
608538003411	25S rRNA binding site [nucleotide binding]; other site
608538003412	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
608538003413	Low molecular weight phosphatase family; Region: LMWPc; cl00105
608538003414	active site
608538003415	Transcriptional regulator [Transcription]; Region: LysR; COG0583
608538003416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
608538003417	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
608538003418	putative dimerization interface [polypeptide binding]; other site
608538003419	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
608538003420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538003421	motif II; other site
608538003422	Uncharacterized conserved protein [Function unknown]; Region: COG2835
608538003423	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
608538003424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003425	FeS/SAM binding site; other site
608538003426	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
608538003427	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
608538003428	MoaE homodimer interface [polypeptide binding]; other site
608538003429	MoaD interaction [polypeptide binding]; other site
608538003430	active site residues [active]
608538003431	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
608538003432	metal ion-dependent adhesion site (MIDAS); other site
608538003433	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
608538003434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
608538003435	Walker A/P-loop; other site
608538003436	ATP binding site [chemical binding]; other site
608538003437	Q-loop/lid; other site
608538003438	ABC transporter signature motif; other site
608538003439	Walker B; other site
608538003440	D-loop; other site
608538003441	H-loop/switch region; other site
608538003442	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
608538003443	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
608538003444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003445	S-adenosylmethionine binding site [chemical binding]; other site
608538003446	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
608538003447	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
608538003448	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
608538003449	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538003450	Cu(I) binding site [ion binding]; other site
608538003451	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
608538003452	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
608538003453	GatB domain; Region: GatB_Yqey; smart00845
608538003454	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
608538003455	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
608538003456	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538003457	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538003458	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538003459	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
608538003460	3-dehydroquinate synthase; Provisional; Region: PRK02290
608538003461	ornithine carbamoyltransferase; Provisional; Region: PRK00779
608538003462	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
608538003463	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
608538003464	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
608538003465	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
608538003466	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
608538003467	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
608538003468	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
608538003469	substrate binding pocket [chemical binding]; other site
608538003470	chain length determination region; other site
608538003471	substrate-Mg2+ binding site; other site
608538003472	catalytic residues [active]
608538003473	aspartate-rich region 1; other site
608538003474	active site lid residues [active]
608538003475	aspartate-rich region 2; other site
608538003476	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14667
608538003477	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
608538003478	GIY-YIG motif/motif A; other site
608538003479	active site
608538003480	catalytic site [active]
608538003481	putative DNA binding site [nucleotide binding]; other site
608538003482	metal binding site [ion binding]; metal-binding site
608538003483	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
608538003484	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
608538003485	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
608538003486	substrate binding pocket [chemical binding]; other site
608538003487	chain length determination region; other site
608538003488	substrate-Mg2+ binding site; other site
608538003489	catalytic residues [active]
608538003490	aspartate-rich region 1; other site
608538003491	active site lid residues [active]
608538003492	aspartate-rich region 2; other site
608538003493	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
608538003494	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
608538003495	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538003496	catalytic residue [active]
608538003497	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
608538003498	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
608538003499	active site
608538003500	catalytic residues [active]
608538003501	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
608538003502	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538003503	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003504	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538003505	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
608538003506	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
608538003507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003508	FeS/SAM binding site; other site
608538003509	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
608538003510	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
608538003511	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538003512	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
608538003513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
608538003514	putative substrate translocation pore; other site
608538003515	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
608538003516	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
608538003517	Lipopolysaccharide-assembly; Region: LptE; cl01125
608538003518	Domain of unknown function DUF302; Region: DUF302; cl01364
608538003519	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
608538003520	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
608538003521	Ferritin-like domain; Region: Ferritin; pfam00210
608538003522	binuclear metal center [ion binding]; other site
608538003523	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538003524	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
608538003525	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
608538003526	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
608538003527	FAD binding pocket [chemical binding]; other site
608538003528	FAD binding motif [chemical binding]; other site
608538003529	phosphate binding motif [ion binding]; other site
608538003530	beta-alpha-beta structure motif; other site
608538003531	NAD binding pocket [chemical binding]; other site
608538003532	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
608538003533	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
608538003534	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
608538003535	Poly A polymerase head domain; Region: PolyA_pol; pfam01743
608538003536	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
608538003537	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
608538003538	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
608538003539	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538003540	Uncharacterized conserved protein [Function unknown]; Region: COG0062
608538003541	putative carbohydrate kinase; Provisional; Region: PRK10565
608538003542	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
608538003543	putative substrate binding site [chemical binding]; other site
608538003544	putative ATP binding site [chemical binding]; other site
608538003545	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
608538003546	dihydrodipicolinate synthase; Region: dapA; TIGR00674
608538003547	dimer interface [polypeptide binding]; other site
608538003548	active site
608538003549	catalytic residue [active]
608538003550	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
608538003551	Endodeoxyribonuclease RusA; Region: RusA; cl01885
608538003552	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003553	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
608538003554	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
608538003555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003556	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
608538003557	Peptidase family M23; Region: Peptidase_M23; pfam01551
608538003558	Acylphosphatase; Region: Acylphosphatase; pfam00708
608538003559	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
608538003560	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
608538003561	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
608538003562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003563	FeS/SAM binding site; other site
608538003564	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538003565	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
608538003566	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
608538003567	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
608538003568	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538003569	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
608538003570	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
608538003571	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
608538003572	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
608538003573	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
608538003574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
608538003575	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
608538003576	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
608538003577	Family of unknown function (DUF694); Region: DUF694; pfam05107
608538003578	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
608538003579	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
608538003580	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538003581	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
608538003582	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
608538003583	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
608538003584	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
608538003585	prolyl-tRNA synthetase; Provisional; Region: PRK09194
608538003586	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
608538003587	dimer interface [polypeptide binding]; other site
608538003588	motif 1; other site
608538003589	active site
608538003590	motif 2; other site
608538003591	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
608538003592	putative deacylase active site [active]
608538003593	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
608538003594	active site
608538003595	motif 3; other site
608538003596	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
608538003597	anticodon binding site; other site
608538003598	AAA domain; Region: AAA_26; pfam13500
608538003599	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
608538003600	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
608538003601	ADP binding site [chemical binding]; other site
608538003602	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
608538003603	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
608538003604	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
608538003605	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
608538003606	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
608538003607	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
608538003608	catalytic site [active]
608538003609	subunit interface [polypeptide binding]; other site
608538003610	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
608538003611	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
608538003612	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
608538003613	active site
608538003614	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
608538003615	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
608538003616	hypothetical protein; Provisional; Region: PRK11573
608538003617	Domain of unknown function DUF21; Region: DUF21; pfam01595
608538003618	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
608538003619	Transporter associated domain; Region: CorC_HlyC; smart01091
608538003620	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
608538003621	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
608538003622	Walker A/P-loop; other site
608538003623	ATP binding site [chemical binding]; other site
608538003624	Q-loop/lid; other site
608538003625	ABC transporter signature motif; other site
608538003626	Walker B; other site
608538003627	D-loop; other site
608538003628	H-loop/switch region; other site
608538003629	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
608538003630	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
608538003631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003632	FeS/SAM binding site; other site
608538003633	HemN C-terminal domain; Region: HemN_C; pfam06969
608538003634	GrpE; Region: GrpE; pfam01025
608538003635	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
608538003636	dimer interface [polypeptide binding]; other site
608538003637	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
608538003638	Uncharacterized conserved protein [Function unknown]; Region: COG1432
608538003639	LabA_like proteins; Region: LabA; cd10911
608538003640	putative metal binding site [ion binding]; other site
608538003641	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
608538003642	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
608538003643	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
608538003644	hypothetical protein; Provisional; Region: PRK08609
608538003645	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
608538003646	active site
608538003647	primer binding site [nucleotide binding]; other site
608538003648	NTP  binding site [chemical binding]; other site
608538003649	metal binding triad [ion binding]; metal-binding site
608538003650	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
608538003651	active site
608538003652	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
608538003653	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
608538003654	domain interfaces; other site
608538003655	active site
608538003656	HerA helicase [Replication, recombination, and repair]; Region: COG0433
608538003657	AMIN domain; Region: AMIN; pfam11741
608538003658	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
608538003659	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
608538003660	active site
608538003661	metal binding site [ion binding]; metal-binding site
608538003662	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
608538003663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003664	FeS/SAM binding site; other site
608538003665	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
608538003666	translation initiation factor IF-2; Region: IF-2; TIGR00487
608538003667	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
608538003668	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
608538003669	G1 box; other site
608538003670	putative GEF interaction site [polypeptide binding]; other site
608538003671	GTP/Mg2+ binding site [chemical binding]; other site
608538003672	Switch I region; other site
608538003673	G2 box; other site
608538003674	G3 box; other site
608538003675	Switch II region; other site
608538003676	G4 box; other site
608538003677	G5 box; other site
608538003678	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
608538003679	Translation-initiation factor 2; Region: IF-2; pfam11987
608538003680	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
608538003681	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
608538003682	biotin synthase; Region: bioB; TIGR00433
608538003683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003684	FeS/SAM binding site; other site
608538003685	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
608538003686	Protein of unknown function (DUF328); Region: DUF328; cl01143
608538003687	Predicted methyltransferases [General function prediction only]; Region: COG0313
608538003688	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
608538003689	putative SAM binding site [chemical binding]; other site
608538003690	putative homodimer interface [polypeptide binding]; other site
608538003691	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003692	Ligand Binding Site [chemical binding]; other site
608538003693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003694	Ligand Binding Site [chemical binding]; other site
608538003695	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
608538003696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538003697	ATP binding site [chemical binding]; other site
608538003698	Mg2+ binding site [ion binding]; other site
608538003699	G-X-G motif; other site
608538003700	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
608538003701	anchoring element; other site
608538003702	dimer interface [polypeptide binding]; other site
608538003703	ATP binding site [chemical binding]; other site
608538003704	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
608538003705	active site
608538003706	putative metal-binding site [ion binding]; other site
608538003707	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
608538003708	Predicted methyltransferases [General function prediction only]; Region: COG1568
608538003709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003710	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
608538003711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538003712	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538003713	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538003714	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
608538003715	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538003716	Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031
608538003717	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538003718	protein binding site [polypeptide binding]; other site
608538003719	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
608538003720	active site
608538003721	HslU subunit interaction site [polypeptide binding]; other site
608538003722	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
608538003723	Putative zinc ribbon domain; Region: DUF164; pfam02591
608538003724	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
608538003725	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
608538003726	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538003727	FeS/SAM binding site; other site
608538003728	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
608538003729	intersubunit interface [polypeptide binding]; other site
608538003730	active site
608538003731	Zn2+ binding site [ion binding]; other site
608538003732	glycine cleavage system protein H; Provisional; Region: PRK13380
608538003733	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538003734	lipoyl attachment site [posttranslational modification]; other site
608538003735	selenocysteine synthase; Provisional; Region: PRK04311
608538003736	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
608538003737	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
608538003738	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
608538003739	G1 box; other site
608538003740	putative GEF interaction site [polypeptide binding]; other site
608538003741	GTP/Mg2+ binding site [chemical binding]; other site
608538003742	Switch I region; other site
608538003743	G2 box; other site
608538003744	G3 box; other site
608538003745	Switch II region; other site
608538003746	G4 box; other site
608538003747	G5 box; other site
608538003748	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
608538003749	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
608538003750	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
608538003751	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
608538003752	active site
608538003753	comF family protein; Region: comF; TIGR00201
608538003754	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538003755	active site
608538003756	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
608538003757	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538003758	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538003759	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538003760	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
608538003761	DHH family; Region: DHH; pfam01368
608538003762	DHHA1 domain; Region: DHHA1; pfam02272
608538003763	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
608538003764	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
608538003765	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
608538003766	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
608538003767	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
608538003768	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
608538003769	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
608538003770	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
608538003771	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
608538003772	active site
608538003773	dimer interface [polypeptide binding]; other site
608538003774	motif 1; other site
608538003775	motif 2; other site
608538003776	motif 3; other site
608538003777	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
608538003778	anticodon binding site; other site
608538003779	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538003780	Ligand Binding Site [chemical binding]; other site
608538003781	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
608538003782	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
608538003783	putative acyl-acceptor binding pocket; other site
608538003784	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
608538003785	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
608538003786	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
608538003787	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
608538003788	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
608538003789	trimerization site [polypeptide binding]; other site
608538003790	active site
608538003791	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
608538003792	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
608538003793	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538003794	CPxP  motif; other site
608538003795	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
608538003796	NifU-like domain; Region: NifU; cl00484
608538003797	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
608538003798	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
608538003799	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
608538003800	shikimate binding site; other site
608538003801	NAD(P) binding site [chemical binding]; other site
608538003802	hypothetical protein; Provisional; Region: PRK04358
608538003803	Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894
608538003804	active site
608538003805	dimer interface [polypeptide binding]; other site
608538003806	GTP-binding protein LepA; Provisional; Region: PRK05433
608538003807	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
608538003808	G1 box; other site
608538003809	putative GEF interaction site [polypeptide binding]; other site
608538003810	GTP/Mg2+ binding site [chemical binding]; other site
608538003811	Switch I region; other site
608538003812	G2 box; other site
608538003813	G3 box; other site
608538003814	Switch II region; other site
608538003815	G4 box; other site
608538003816	G5 box; other site
608538003817	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
608538003818	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
608538003819	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
608538003820	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
608538003821	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
608538003822	generic binding surface II; other site
608538003823	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538003824	ATP binding site [chemical binding]; other site
608538003825	putative Mg++ binding site [ion binding]; other site
608538003826	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538003827	nucleotide binding region [chemical binding]; other site
608538003828	ATP-binding site [chemical binding]; other site
608538003829	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
608538003830	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
608538003831	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
608538003832	GMP synthase; Reviewed; Region: guaA; PRK00074
608538003833	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
608538003834	AMP/PPi binding site [chemical binding]; other site
608538003835	candidate oxyanion hole; other site
608538003836	catalytic triad [active]
608538003837	potential glutamine specificity residues [chemical binding]; other site
608538003838	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
608538003839	ATP Binding subdomain [chemical binding]; other site
608538003840	Ligand Binding sites [chemical binding]; other site
608538003841	Dimerization subdomain; other site
608538003842	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
608538003843	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
608538003844	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
608538003845	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
608538003846	Walker A/P-loop; other site
608538003847	ATP binding site [chemical binding]; other site
608538003848	Q-loop/lid; other site
608538003849	ABC transporter signature motif; other site
608538003850	Walker B; other site
608538003851	D-loop; other site
608538003852	H-loop/switch region; other site
608538003853	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
608538003854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538003855	dimer interface [polypeptide binding]; other site
608538003856	conserved gate region; other site
608538003857	putative PBP binding loops; other site
608538003858	ABC-ATPase subunit interface; other site
608538003859	TOBE domain; Region: TOBE; cl01440
608538003860	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
608538003861	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
608538003862	TOBE domain; Region: TOBE; cl01440
608538003863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
608538003864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
608538003865	non-specific DNA binding site [nucleotide binding]; other site
608538003866	salt bridge; other site
608538003867	sequence-specific DNA binding site [nucleotide binding]; other site
608538003868	PBP superfamily domain; Region: PBP_like; pfam12727
608538003869	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003870	metal-binding site [ion binding]
608538003871	mercuric reductase; Region: MerA; TIGR02053
608538003872	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538003873	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003874	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538003875	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003876	metal-binding site [ion binding]
608538003877	MerT mercuric transport protein; Region: MerT; cl03578
608538003878	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
608538003879	putative homodimer interface [polypeptide binding]; other site
608538003880	putative homotetramer interface [polypeptide binding]; other site
608538003881	putative allosteric switch controlling residues; other site
608538003882	putative metal binding site [ion binding]; other site
608538003883	putative homodimer-homodimer interface [polypeptide binding]; other site
608538003884	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
608538003885	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
608538003886	GTP binding site; other site
608538003887	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538003888	metal-binding site [ion binding]
608538003889	Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112
608538003890	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
608538003891	active site
608538003892	substrate binding site [chemical binding]; other site
608538003893	ATP binding site [chemical binding]; other site
608538003894	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
608538003895	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
608538003896	minor groove reading motif; other site
608538003897	helix-hairpin-helix signature motif; other site
608538003898	substrate binding pocket [chemical binding]; other site
608538003899	active site
608538003900	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
608538003901	Cytochrome c; Region: Cytochrom_C; cl11414
608538003902	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
608538003903	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
608538003904	intrachain domain interface; other site
608538003905	interchain domain interface [polypeptide binding]; other site
608538003906	heme bH binding site [chemical binding]; other site
608538003907	heme bL binding site [chemical binding]; other site
608538003908	Qo binding site; other site
608538003909	interchain domain interface [polypeptide binding]; other site
608538003910	intrachain domain interface; other site
608538003911	Qi binding site; other site
608538003912	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
608538003913	Qo binding site; other site
608538003914	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
608538003915	iron-sulfur cluster [ion binding]; other site
608538003916	[2Fe-2S] cluster binding site [ion binding]; other site
608538003917	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
608538003918	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
608538003919	active site
608538003920	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
608538003921	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538003922	putative ADP-binding pocket [chemical binding]; other site
608538003923	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
608538003924	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538003925	MutS2 family protein; Region: mutS2; TIGR01069
608538003926	MutS domain III; Region: MutS_III; pfam05192
608538003927	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
608538003928	Walker A/P-loop; other site
608538003929	ATP binding site [chemical binding]; other site
608538003930	Q-loop/lid; other site
608538003931	ABC transporter signature motif; other site
608538003932	Walker B; other site
608538003933	D-loop; other site
608538003934	H-loop/switch region; other site
608538003935	Smr domain; Region: Smr; pfam01713
608538003936	potential frameshift: common BLAST hit: gi|288817812|ref|YP_003432159.1| transposase
608538003937	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538003938	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
608538003939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538003940	TPR motif; other site
608538003941	TPR repeat; Region: TPR_11; pfam13414
608538003942	binding surface
608538003943	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538003944	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
608538003945	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
608538003946	catalytic residues [active]
608538003947	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538003948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538003949	S-adenosylmethionine binding site [chemical binding]; other site
608538003950	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
608538003951	ligand binding site; other site
608538003952	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
608538003953	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
608538003954	inhibitor-cofactor binding pocket; inhibition site
608538003955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003956	catalytic residue [active]
608538003957	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003958	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003959	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
608538003960	active site
608538003961	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
608538003962	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
608538003963	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
608538003964	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
608538003965	Protein of unknown function (DUF434); Region: DUF434; cl04460
608538003966	NosL; Region: NosL; cl01769
608538003967	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
608538003968	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
608538003969	dimerization domain [polypeptide binding]; other site
608538003970	dimer interface [polypeptide binding]; other site
608538003971	catalytic residues [active]
608538003972	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
608538003973	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
608538003974	substrate-cofactor binding pocket; other site
608538003975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538003976	catalytic residue [active]
608538003977	MoxR-like ATPases [General function prediction only]; Region: COG0714
608538003978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538003979	Walker A motif; other site
608538003980	ATP binding site [chemical binding]; other site
608538003981	Walker B motif; other site
608538003982	arginine finger; other site
608538003983	reverse gyrase; Reviewed; Region: PRK09401
608538003984	DEAD/DEAH box helicase; Region: DEAD; pfam00270
608538003985	ATP binding site [chemical binding]; other site
608538003986	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
608538003987	active site
608538003988	metal binding site [ion binding]; metal-binding site
608538003989	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
608538003990	domain I; other site
608538003991	DNA binding groove [nucleotide binding]
608538003992	phosphate binding site [ion binding]; other site
608538003993	domain II; other site
608538003994	domain III; other site
608538003995	nucleotide binding site [chemical binding]; other site
608538003996	catalytic site [active]
608538003997	domain IV; other site
608538003998	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
608538003999	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
608538004000	TPP-binding site; other site
608538004001	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
608538004002	PYR/PP interface [polypeptide binding]; other site
608538004003	dimer interface [polypeptide binding]; other site
608538004004	TPP binding site [chemical binding]; other site
608538004005	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538004006	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
608538004007	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
608538004008	putative NAD(P) binding site [chemical binding]; other site
608538004009	active site
608538004010	putative substrate binding site [chemical binding]; other site
608538004011	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
608538004012	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
608538004013	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538004014	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
608538004015	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004016	motif II; other site
608538004017	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
608538004018	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538004019	DNA primase, catalytic core; Region: dnaG; TIGR01391
608538004020	CHC2 zinc finger; Region: zf-CHC2; pfam01807
608538004021	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
608538004022	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
608538004023	active site
608538004024	metal binding site [ion binding]; metal-binding site
608538004025	interdomain interaction site; other site
608538004026	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
608538004027	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
608538004028	active site
608538004029	catalytic residues [active]
608538004030	metal binding site [ion binding]; metal-binding site
608538004031	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
608538004032	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
608538004033	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
608538004034	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
608538004035	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
608538004036	Catalytic dyad [active]
608538004037	UGMP family protein; Validated; Region: PRK09604
608538004038	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
608538004039	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
608538004040	active site
608538004041	Ap6A binding site [chemical binding]; other site
608538004042	nudix motif; other site
608538004043	metal binding site [ion binding]; metal-binding site
608538004044	threonine synthase; Reviewed; Region: PRK06721
608538004045	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
608538004046	homodimer interface [polypeptide binding]; other site
608538004047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004048	catalytic residue [active]
608538004049	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
608538004050	Thymidylate synthase complementing protein; Region: Thy1; cl03630
608538004051	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
608538004052	hypothetical protein; Provisional; Region: PRK11820
608538004053	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
608538004054	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
608538004055	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
608538004056	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
608538004057	catalytic residues [active]
608538004058	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
608538004059	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
608538004060	ATP synthase subunit C; Region: ATP-synt_C; cl00466
608538004061	hypothetical protein; Provisional; Region: PRK14382
608538004062	membrane protein insertase; Provisional; Region: PRK01318
608538004063	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
608538004064	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
608538004065	selenium donor protein; Region: selD; TIGR00476
608538004066	dimerization interface [polypeptide binding]; other site
608538004067	putative ATP binding site [chemical binding]; other site
608538004068	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
608538004069	MoaE interaction surface [polypeptide binding]; other site
608538004070	MoeB interaction surface [polypeptide binding]; other site
608538004071	thiocarboxylated glycine; other site
608538004072	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538004073	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538004074	putative active site [active]
608538004075	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
608538004076	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
608538004077	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
608538004078	active site
608538004079	Zn binding site [ion binding]; other site
608538004080	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
608538004081	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
608538004082	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
608538004083	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
608538004084	pyruvate carboxylase subunit B; Validated; Region: PRK09282
608538004085	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
608538004086	active site
608538004087	catalytic residues [active]
608538004088	metal binding site [ion binding]; metal-binding site
608538004089	homodimer binding site [polypeptide binding]; other site
608538004090	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538004091	carboxyltransferase (CT) interaction site; other site
608538004092	biotinylation site [posttranslational modification]; other site
608538004093	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538004094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538004095	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
608538004096	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
608538004097	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
608538004098	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
608538004099	Chorismate mutase type II; Region: CM_2; pfam01817
608538004100	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
608538004101	Prephenate dehydratase; Region: PDT; pfam00800
608538004102	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
608538004103	putative L-Phe binding site [chemical binding]; other site
608538004104	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
608538004105	Protein of unknown function DUF58; Region: DUF58; pfam01882
608538004106	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
608538004107	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
608538004108	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
608538004109	Mechanosensitive ion channel; Region: MS_channel; pfam00924
608538004110	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538004111	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538004112	putative active site [active]
608538004113	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
608538004114	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
608538004115	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
608538004116	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
608538004117	putative ligand binding site [chemical binding]; other site
608538004118	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
608538004119	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
608538004120	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
608538004121	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
608538004122	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
608538004123	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
608538004124	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004125	binding surface
608538004126	TPR motif; other site
608538004127	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
608538004128	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
608538004129	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
608538004130	P loop; other site
608538004131	GTP binding site [chemical binding]; other site
608538004132	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
608538004133	NADH dehydrogenase subunit B; Validated; Region: PRK06411
608538004134	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
608538004135	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
608538004136	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
608538004137	NADH dehydrogenase subunit D; Validated; Region: PRK06075
608538004138	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
608538004139	Ligand Binding Site [chemical binding]; other site
608538004140	pteridine reductase; Provisional; Region: PRK09135
608538004141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
608538004142	NAD(P) binding site [chemical binding]; other site
608538004143	active site
608538004144	threonine synthase; Validated; Region: PRK07591
608538004145	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
608538004146	homodimer interface [polypeptide binding]; other site
608538004147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004148	catalytic residue [active]
608538004149	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
608538004150	catalytic residues [active]
608538004151	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
608538004152	ATP-grasp domain; Region: ATP-grasp; pfam02222
608538004153	L-aspartate oxidase; Provisional; Region: PRK06175
608538004154	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
608538004155	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
608538004156	Domain of unknown function (DUF202); Region: DUF202; cl09954
608538004157	Domain of unknown function (DUF202); Region: DUF202; cl09954
608538004158	adenylosuccinate lyase; Provisional; Region: PRK07492
608538004159	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
608538004160	tetramer interface [polypeptide binding]; other site
608538004161	active site
608538004162	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
608538004163	Domain of unknown function DUF29; Region: DUF29; pfam01724
608538004164	amidophosphoribosyltransferase; Region: purF; TIGR01134
608538004165	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
608538004166	active site
608538004167	tetramer interface [polypeptide binding]; other site
608538004168	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538004169	active site
608538004170	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
608538004171	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
608538004172	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
608538004173	dimer interface [polypeptide binding]; other site
608538004174	motif 1; other site
608538004175	active site
608538004176	motif 2; other site
608538004177	motif 3; other site
608538004178	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
608538004179	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
608538004180	RNA binding site [nucleotide binding]; other site
608538004181	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
608538004182	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
608538004183	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
608538004184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004185	binding surface
608538004186	TPR motif; other site
608538004187	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538004188	G1 box; other site
608538004189	GTP/Mg2+ binding site [chemical binding]; other site
608538004190	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
608538004191	G2 box; other site
608538004192	Switch I region; other site
608538004193	G3 box; other site
608538004194	Switch II region; other site
608538004195	G4 box; other site
608538004196	G5 box; other site
608538004197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004199	active site
608538004200	phosphorylation site [posttranslational modification]
608538004201	intermolecular recognition site; other site
608538004202	dimerization interface [polypeptide binding]; other site
608538004203	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004204	DNA binding site [nucleotide binding]
608538004205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538004206	HAMP domain; Region: HAMP; pfam00672
608538004207	dimerization interface [polypeptide binding]; other site
608538004208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538004209	dimer interface [polypeptide binding]; other site
608538004210	phosphorylation site [posttranslational modification]
608538004211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538004212	ATP binding site [chemical binding]; other site
608538004213	Mg2+ binding site [ion binding]; other site
608538004214	G-X-G motif; other site
608538004215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004216	TPR motif; other site
608538004217	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
608538004218	metal binding site 2 [ion binding]; metal-binding site
608538004219	putative DNA binding helix; other site
608538004220	metal binding site 1 [ion binding]; metal-binding site
608538004221	dimer interface [polypeptide binding]; other site
608538004222	structural Zn2+ binding site [ion binding]; other site
608538004223	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
608538004224	aromatic arch; other site
608538004225	DCoH dimer interaction site [polypeptide binding]; other site
608538004226	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
608538004227	DCoH tetramer interaction site [polypeptide binding]; other site
608538004228	substrate binding site [chemical binding]; other site
608538004229	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
608538004230	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
608538004231	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
608538004232	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
608538004233	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
608538004234	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
608538004235	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
608538004236	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
608538004237	RNA/DNA hybrid binding site [nucleotide binding]; other site
608538004238	active site
608538004239	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
608538004240	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
608538004241	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
608538004242	pyruvate carboxylase subunit B; Validated; Region: PRK09282
608538004243	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
608538004244	active site
608538004245	catalytic residues [active]
608538004246	metal binding site [ion binding]; metal-binding site
608538004247	homodimer binding site [polypeptide binding]; other site
608538004248	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538004249	carboxyltransferase (CT) interaction site; other site
608538004250	biotinylation site [posttranslational modification]; other site
608538004251	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004253	active site
608538004254	phosphorylation site [posttranslational modification]
608538004255	intermolecular recognition site; other site
608538004256	dimerization interface [polypeptide binding]; other site
608538004257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004258	DNA binding site [nucleotide binding]
608538004259	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
608538004260	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
608538004261	putative active site [active]
608538004262	putative metal binding site [ion binding]; other site
608538004263	CTP synthetase; Validated; Region: pyrG; PRK05380
608538004264	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
608538004265	Catalytic site [active]
608538004266	active site
608538004267	UTP binding site [chemical binding]; other site
608538004268	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
608538004269	active site
608538004270	putative oxyanion hole; other site
608538004271	catalytic triad [active]
608538004272	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
608538004273	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
608538004274	Moco binding site; other site
608538004275	metal coordination site [ion binding]; other site
608538004276	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
608538004277	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
608538004278	RNA binding surface [nucleotide binding]; other site
608538004279	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
608538004280	active site
608538004281	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538004282	catalytic residues [active]
608538004283	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
608538004284	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
608538004285	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
608538004286	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
608538004287	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
608538004288	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004289	Cytochrome c; Region: Cytochrom_C; pfam00034
608538004290	Cytochrome c; Region: Cytochrom_C; cl11414
608538004291	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
608538004292	ATP-dependent DNA ligase; Provisional; Region: PRK01109
608538004293	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
608538004294	active site
608538004295	DNA binding site [nucleotide binding]
608538004296	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_I; cd07969
608538004297	DNA binding site [nucleotide binding]
608538004298	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
608538004299	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
608538004300	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
608538004301	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538004302	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
608538004303	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538004304	DNA binding residues [nucleotide binding]
608538004305	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
608538004306	FMN binding site [chemical binding]; other site
608538004307	dimer interface [polypeptide binding]; other site
608538004308	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
608538004309	active site
608538004310	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
608538004311	Type III pantothenate kinase; Region: Pan_kinase; cl17198
608538004312	homoserine kinase; Provisional; Region: PRK01212
608538004313	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
608538004314	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
608538004315	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
608538004316	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
608538004317	NlpC/P60 family; Region: NLPC_P60; cl17555
608538004318	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
608538004319	ApbE family; Region: ApbE; pfam02424
608538004320	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
608538004321	Subunit I/III interface [polypeptide binding]; other site
608538004322	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538004323	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
608538004324	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
608538004325	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
608538004326	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
608538004327	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
608538004328	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538004329	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
608538004330	Hemerythrin; Region: Hemerythrin; cd12107
608538004331	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
608538004332	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
608538004333	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
608538004334	Low-spin heme binding site [chemical binding]; other site
608538004335	D-pathway; other site
608538004336	Putative water exit pathway; other site
608538004337	Binuclear center (active site) [active]
608538004338	K-pathway; other site
608538004339	Putative proton exit pathway; other site
608538004340	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
608538004341	Cu(I) binding site [ion binding]; other site
608538004342	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
608538004343	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
608538004344	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
608538004345	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
608538004346	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
608538004347	30S subunit binding site; other site
608538004348	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
608538004349	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
608538004350	active site
608538004351	substrate binding site [chemical binding]; other site
608538004352	cosubstrate binding site; other site
608538004353	catalytic site [active]
608538004354	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
608538004355	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
608538004356	tetramer interface [polypeptide binding]; other site
608538004357	TPP-binding site [chemical binding]; other site
608538004358	heterodimer interface [polypeptide binding]; other site
608538004359	phosphorylation loop region [posttranslational modification]
608538004360	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
608538004361	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
608538004362	alpha subunit interface [polypeptide binding]; other site
608538004363	TPP binding site [chemical binding]; other site
608538004364	heterodimer interface [polypeptide binding]; other site
608538004365	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538004366	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
608538004367	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
608538004368	E3 interaction surface; other site
608538004369	lipoyl attachment site [posttranslational modification]; other site
608538004370	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
608538004371	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
608538004372	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
608538004373	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538004374	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
608538004375	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
608538004376	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
608538004377	active site
608538004378	dimerization interface [polypeptide binding]; other site
608538004379	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538004380	Ligand Binding Site [chemical binding]; other site
608538004381	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
608538004382	Ligand Binding Site [chemical binding]; other site
608538004383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004384	binding surface
608538004385	TPR motif; other site
608538004386	Tetratricopeptide repeat; Region: TPR_16; pfam13432
608538004387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004388	binding surface
608538004389	TPR motif; other site
608538004390	Tetratricopeptide repeat; Region: TPR_16; pfam13432
608538004391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004392	binding surface
608538004393	TPR motif; other site
608538004394	Tetratricopeptide repeat; Region: TPR_15; pfam13429
608538004395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004396	TPR motif; other site
608538004397	binding surface
608538004398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538004399	TPR motif; other site
608538004400	binding surface
608538004401	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
608538004402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004403	active site
608538004404	phosphorylation site [posttranslational modification]
608538004405	intermolecular recognition site; other site
608538004406	dimerization interface [polypeptide binding]; other site
608538004407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004408	Walker A motif; other site
608538004409	ATP binding site [chemical binding]; other site
608538004410	Walker B motif; other site
608538004411	arginine finger; other site
608538004412	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004414	active site
608538004415	phosphorylation site [posttranslational modification]
608538004416	intermolecular recognition site; other site
608538004417	dimerization interface [polypeptide binding]; other site
608538004418	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
608538004419	DNA binding site [nucleotide binding]
608538004420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538004421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538004422	dimer interface [polypeptide binding]; other site
608538004423	phosphorylation site [posttranslational modification]
608538004424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538004425	ATP binding site [chemical binding]; other site
608538004426	Mg2+ binding site [ion binding]; other site
608538004427	G-X-G motif; other site
608538004428	Outer membrane efflux protein; Region: OEP; pfam02321
608538004429	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538004430	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
608538004431	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538004432	putative membrane fusion protein; Region: TIGR02828
608538004433	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538004434	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
608538004435	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
608538004436	Sulfate transporter family; Region: Sulfate_transp; pfam00916
608538004437	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
608538004438	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
608538004439	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
608538004440	active site
608538004441	(T/H)XGH motif; other site
608538004442	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
608538004443	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538004444	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538004445	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
608538004446	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
608538004447	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
608538004448	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
608538004449	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004450	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004451	Cytochrome c [Energy production and conversion]; Region: COG3258
608538004452	Cytochrome c; Region: Cytochrom_C; pfam00034
608538004453	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
608538004454	active site
608538004455	metal binding site [ion binding]; metal-binding site
608538004456	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
608538004457	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
608538004458	Domain of unknown function DUF302; Region: DUF302; cl01364
608538004459	Domain of unknown function DUF302; Region: DUF302; cl01364
608538004460	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
608538004461	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
608538004462	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
608538004463	nucleotide binding site/active site [active]
608538004464	HIT family signature motif; other site
608538004465	catalytic residue [active]
608538004466	Uncharacterized conserved protein [Function unknown]; Region: COG1565
608538004467	tartrate dehydrogenase; Region: TTC; TIGR02089
608538004468	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
608538004469	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
608538004470	Cysteine-rich domain; Region: CCG; pfam02754
608538004471	Cysteine-rich domain; Region: CCG; pfam02754
608538004472	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
608538004473	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538004474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004475	homodimer interface [polypeptide binding]; other site
608538004476	catalytic residue [active]
608538004477	Protein of unknown function, DUF399; Region: DUF399; pfam04187
608538004478	recombination protein RecR; Region: recR; TIGR00615
608538004479	RecR protein; Region: RecR; pfam02132
608538004480	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
608538004481	putative active site [active]
608538004482	putative metal-binding site [ion binding]; other site
608538004483	tetramer interface [polypeptide binding]; other site
608538004484	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
608538004485	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
608538004486	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
608538004487	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538004488	lipoyl attachment site [posttranslational modification]; other site
608538004489	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
608538004490	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
608538004491	tetramer interface [polypeptide binding]; other site
608538004492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004493	catalytic residue [active]
608538004494	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
608538004495	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
608538004496	pseudaminic acid synthase; Region: PseI; TIGR03586
608538004497	NeuB family; Region: NeuB; pfam03102
608538004498	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
608538004499	NeuB binding interface [polypeptide binding]; other site
608538004500	putative substrate binding site [chemical binding]; other site
608538004501	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
608538004502	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
608538004503	NAD(P) binding site [chemical binding]; other site
608538004504	homodimer interface [polypeptide binding]; other site
608538004505	substrate binding site [chemical binding]; other site
608538004506	active site
608538004507	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538004508	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
608538004509	inhibitor-cofactor binding pocket; inhibition site
608538004510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538004511	catalytic residue [active]
608538004512	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
608538004513	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
608538004514	active site
608538004515	catalytic tetrad [active]
608538004516	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004517	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
608538004518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004519	Walker A motif; other site
608538004520	ATP binding site [chemical binding]; other site
608538004521	Walker B motif; other site
608538004522	arginine finger; other site
608538004523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004524	Walker A motif; other site
608538004525	ATP binding site [chemical binding]; other site
608538004526	Walker B motif; other site
608538004527	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
608538004528	GTP-binding protein Der; Reviewed; Region: PRK00093
608538004529	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
608538004530	G1 box; other site
608538004531	GTP/Mg2+ binding site [chemical binding]; other site
608538004532	Switch I region; other site
608538004533	G2 box; other site
608538004534	Switch II region; other site
608538004535	G3 box; other site
608538004536	G4 box; other site
608538004537	G5 box; other site
608538004538	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
608538004539	G1 box; other site
608538004540	GTP/Mg2+ binding site [chemical binding]; other site
608538004541	Switch I region; other site
608538004542	G2 box; other site
608538004543	G3 box; other site
608538004544	Switch II region; other site
608538004545	G4 box; other site
608538004546	G5 box; other site
608538004547	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
608538004548	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
608538004549	Walker A/P-loop; other site
608538004550	ATP binding site [chemical binding]; other site
608538004551	Q-loop/lid; other site
608538004552	ABC transporter signature motif; other site
608538004553	Walker B; other site
608538004554	D-loop; other site
608538004555	H-loop/switch region; other site
608538004556	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
608538004557	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
608538004558	nucleotide binding site/active site [active]
608538004559	HIT family signature motif; other site
608538004560	catalytic residue [active]
608538004561	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
608538004562	catalytic residues [active]
608538004563	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
608538004564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
608538004565	N-terminal plug; other site
608538004566	ligand-binding site [chemical binding]; other site
608538004567	Response regulator receiver domain; Region: Response_reg; pfam00072
608538004568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004569	active site
608538004570	phosphorylation site [posttranslational modification]
608538004571	intermolecular recognition site; other site
608538004572	dimerization interface [polypeptide binding]; other site
608538004573	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
608538004574	Histidine kinase; Region: HisKA_2; pfam07568
608538004575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
608538004576	Mg2+ binding site [ion binding]; other site
608538004577	NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005
608538004578	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
608538004579	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
608538004580	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
608538004581	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
608538004582	TPP-binding site [chemical binding]; other site
608538004583	dimer interface [polypeptide binding]; other site
608538004584	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
608538004585	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
608538004586	dimer interface [polypeptide binding]; other site
608538004587	PYR/PP interface [polypeptide binding]; other site
608538004588	TPP binding site [chemical binding]; other site
608538004589	substrate binding site [chemical binding]; other site
608538004590	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
608538004591	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
608538004592	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
608538004593	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
608538004594	protein binding site [polypeptide binding]; other site
608538004595	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
608538004596	Active site serine [active]
608538004597	Predicted kinase [General function prediction only]; Region: COG0645
608538004598	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
608538004599	ATP-binding site [chemical binding]; other site
608538004600	Gluconate-6-phosphate binding site [chemical binding]; other site
608538004601	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
608538004602	catalytic residues [active]
608538004603	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
608538004604	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
608538004605	active site
608538004606	catalytic site [active]
608538004607	substrate binding site [chemical binding]; other site
608538004608	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
608538004609	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538004610	ligand binding site [chemical binding]; other site
608538004611	flexible hinge region; other site
608538004612	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
608538004613	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
608538004614	metal binding triad; other site
608538004615	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
608538004616	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
608538004617	Na binding site [ion binding]; other site
608538004618	Protein of unknown function, DUF485; Region: DUF485; pfam04341
608538004619	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
608538004620	thiS-thiF/thiG interaction site; other site
608538004621	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
608538004622	ThiS interaction site; other site
608538004623	putative active site [active]
608538004624	tetramer interface [polypeptide binding]; other site
608538004625	protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562
608538004626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538004627	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
608538004628	active site
608538004629	intersubunit interactions; other site
608538004630	catalytic residue [active]
608538004631	RIP metalloprotease RseP; Region: TIGR00054
608538004632	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
608538004633	active site
608538004634	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
608538004635	protein binding site [polypeptide binding]; other site
608538004636	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
608538004637	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
608538004638	putative substrate binding region [chemical binding]; other site
608538004639	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
608538004640	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
608538004641	V4R domain; Region: V4R; cl15268
608538004642	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
608538004643	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
608538004644	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
608538004645	NAD binding site [chemical binding]; other site
608538004646	homodimer interface [polypeptide binding]; other site
608538004647	active site
608538004648	substrate binding site [chemical binding]; other site
608538004649	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
608538004650	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004651	Clp amino terminal domain; Region: Clp_N; pfam02861
608538004652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004653	Walker A motif; other site
608538004654	ATP binding site [chemical binding]; other site
608538004655	Walker B motif; other site
608538004656	arginine finger; other site
608538004657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538004658	Walker A motif; other site
608538004659	ATP binding site [chemical binding]; other site
608538004660	Walker B motif; other site
608538004661	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
608538004662	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004663	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004664	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
608538004665	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004666	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004667	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
608538004668	Actin cytoskeleton-regulatory complex protein END3; Region: End3; pfam12761
608538004669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004670	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004671	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
608538004672	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004673	active site
608538004674	motif I; other site
608538004675	motif II; other site
608538004676	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
608538004677	Cupin domain; Region: Cupin_2; pfam07883
608538004678	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
608538004679	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
608538004680	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
608538004681	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
608538004682	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
608538004683	Nitrogen regulatory protein P-II; Region: P-II; smart00938
608538004684	glutamine synthetase, type I; Region: GlnA; TIGR00653
608538004685	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
608538004686	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
608538004687	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
608538004688	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
608538004689	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
608538004690	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004691	active site
608538004692	motif I; other site
608538004693	motif II; other site
608538004694	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004695	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
608538004696	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
608538004697	catalytic triad [active]
608538004698	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
608538004699	RNase III inhibitor; Provisional; Region: PRK00431
608538004700	ADP-ribose binding site [chemical binding]; other site
608538004701	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
608538004702	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
608538004703	motif 1; other site
608538004704	dimer interface [polypeptide binding]; other site
608538004705	active site
608538004706	motif 2; other site
608538004707	motif 3; other site
608538004708	S-adenosylmethionine synthetase; Validated; Region: PRK05250
608538004709	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
608538004710	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
608538004711	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
608538004712	seryl-tRNA synthetase; Provisional; Region: PRK05431
608538004713	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
608538004714	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
608538004715	dimer interface [polypeptide binding]; other site
608538004716	active site
608538004717	motif 1; other site
608538004718	motif 2; other site
608538004719	motif 3; other site
608538004720	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
608538004721	nudix motif; other site
608538004722	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
608538004723	active site residue [active]
608538004724	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538004725	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538004726	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
608538004727	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
608538004728	Hemerythrin; Region: Hemerythrin; cd12107
608538004729	Fe binding site [ion binding]; other site
608538004730	NIL domain; Region: NIL; pfam09383
608538004731	thiamine-monophosphate kinase; Region: thiL; TIGR01379
608538004732	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
608538004733	ATP binding site [chemical binding]; other site
608538004734	dimerization interface [polypeptide binding]; other site
608538004735	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
608538004736	SmpB-tmRNA interface; other site
608538004737	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
608538004738	Protein of unknown function DUF116; Region: DUF116; pfam01976
608538004739	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
608538004740	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
608538004741	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
608538004742	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538004743	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
608538004744	phenylalanine ammonia-lyase; Region: PLN02457
608538004745	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
608538004746	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
608538004747	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
608538004748	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
608538004749	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
608538004750	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
608538004751	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
608538004752	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
608538004753	putative active site [active]
608538004754	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
608538004755	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
608538004756	dimer interface [polypeptide binding]; other site
608538004757	substrate binding site [chemical binding]; other site
608538004758	metal binding sites [ion binding]; metal-binding site
608538004759	Protein of unknown function (DUF420); Region: DUF420; cl00989
608538004760	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
608538004761	metal binding site 2 [ion binding]; metal-binding site
608538004762	putative DNA binding helix; other site
608538004763	metal binding site 1 [ion binding]; metal-binding site
608538004764	dimer interface [polypeptide binding]; other site
608538004765	structural Zn2+ binding site [ion binding]; other site
608538004766	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
608538004767	DNA methylase; Region: N6_N4_Mtase; pfam01555
608538004768	DEAD-like helicases superfamily; Region: DEXDc; smart00487
608538004769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538004770	ATP binding site [chemical binding]; other site
608538004771	putative Mg++ binding site [ion binding]; other site
608538004772	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
608538004773	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
608538004774	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
608538004775	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
608538004776	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
608538004777	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
608538004778	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
608538004779	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538004780	ligand binding site [chemical binding]; other site
608538004781	flexible hinge region; other site
608538004782	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
608538004783	non-specific DNA interactions [nucleotide binding]; other site
608538004784	DNA binding site [nucleotide binding]
608538004785	sequence specific DNA binding site [nucleotide binding]; other site
608538004786	putative cAMP binding site [chemical binding]; other site
608538004787	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
608538004788	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
608538004789	purine monophosphate binding site [chemical binding]; other site
608538004790	dimer interface [polypeptide binding]; other site
608538004791	putative catalytic residues [active]
608538004792	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
608538004793	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
608538004794	Preprotein translocase subunit; Region: YajC; pfam02699
608538004795	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
608538004796	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
608538004797	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
608538004798	ScpA/B protein; Region: ScpA_ScpB; cl00598
608538004799	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
608538004800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538004801	S-adenosylmethionine binding site [chemical binding]; other site
608538004802	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
608538004803	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
608538004804	ketol-acid reductoisomerase; Provisional; Region: PRK05479
608538004805	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
608538004806	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
608538004807	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
608538004808	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
608538004809	RibD C-terminal domain; Region: RibD_C; cl17279
608538004810	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
608538004811	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
608538004812	FMN binding site [chemical binding]; other site
608538004813	substrate binding site [chemical binding]; other site
608538004814	putative catalytic residue [active]
608538004815	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
608538004816	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
608538004817	Glucose inhibited division protein A; Region: GIDA; pfam01134
608538004818	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
608538004819	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
608538004820	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
608538004821	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
608538004822	Walker A/P-loop; other site
608538004823	ATP binding site [chemical binding]; other site
608538004824	Q-loop/lid; other site
608538004825	ABC transporter signature motif; other site
608538004826	Walker B; other site
608538004827	D-loop; other site
608538004828	H-loop/switch region; other site
608538004829	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
608538004830	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
608538004831	Protein export membrane protein; Region: SecD_SecF; pfam02355
608538004832	Tetratricopeptide repeat; Region: TPR_16; pfam13432
608538004833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538004834	binding surface
608538004835	TPR motif; other site
608538004836	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
608538004837	phosphoenolpyruvate synthase; Validated; Region: PRK06464
608538004838	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
608538004839	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
608538004840	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
608538004841	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
608538004842	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
608538004843	type II secretion system protein D; Region: type_II_gspD; TIGR02517
608538004844	Secretin and TonB N terminus short domain; Region: STN; smart00965
608538004845	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
608538004846	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
608538004847	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004848	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538004850	S-adenosylmethionine binding site [chemical binding]; other site
608538004851	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
608538004852	Ligand binding site; other site
608538004853	Putative Catalytic site; other site
608538004854	DXD motif; other site
608538004855	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
608538004856	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
608538004857	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
608538004858	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
608538004859	Uncharacterized conserved protein [Function unknown]; Region: COG1624
608538004860	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
608538004861	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
608538004862	dihydropteroate synthase; Region: DHPS; TIGR01496
608538004863	substrate binding pocket [chemical binding]; other site
608538004864	dimer interface [polypeptide binding]; other site
608538004865	inhibitor binding site; inhibition site
608538004866	DNA adenine methylase (dam); Region: dam; TIGR00571
608538004867	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
608538004868	putative active site [active]
608538004869	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
608538004870	thymidylate kinase; Validated; Region: tmk; PRK00698
608538004871	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
608538004872	TMP-binding site; other site
608538004873	ATP-binding site [chemical binding]; other site
608538004874	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
608538004875	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
608538004876	catalytic triad [active]
608538004877	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
608538004878	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
608538004879	dimer interface [polypeptide binding]; other site
608538004880	active site
608538004881	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
608538004882	dimer interface [polypeptide binding]; other site
608538004883	active site
608538004884	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
608538004885	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
608538004886	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
608538004887	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
608538004888	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
608538004889	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
608538004890	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
608538004891	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
608538004892	putative dimer interface [polypeptide binding]; other site
608538004893	[2Fe-2S] cluster binding site [ion binding]; other site
608538004894	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
608538004895	putative dimer interface [polypeptide binding]; other site
608538004896	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
608538004897	SLBB domain; Region: SLBB; pfam10531
608538004898	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
608538004899	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
608538004900	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
608538004901	catalytic loop [active]
608538004902	iron binding site [ion binding]; other site
608538004903	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
608538004904	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
608538004905	[4Fe-4S] binding site [ion binding]; other site
608538004906	molybdopterin cofactor binding site; other site
608538004907	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
608538004908	molybdopterin cofactor binding site; other site
608538004909	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
608538004910	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
608538004911	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
608538004912	23S rRNA binding site [nucleotide binding]; other site
608538004913	L21 binding site [polypeptide binding]; other site
608538004914	L13 binding site [polypeptide binding]; other site
608538004915	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
608538004916	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
608538004917	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
608538004918	dimer interface [polypeptide binding]; other site
608538004919	motif 1; other site
608538004920	active site
608538004921	motif 2; other site
608538004922	motif 3; other site
608538004923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
608538004924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
608538004925	dimer interface [polypeptide binding]; other site
608538004926	phosphorylation site [posttranslational modification]
608538004927	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
608538004928	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
608538004929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
608538004930	active site
608538004931	phosphorylation site [posttranslational modification]
608538004932	intermolecular recognition site; other site
608538004933	dimerization interface [polypeptide binding]; other site
608538004934	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
608538004935	DNA binding site [nucleotide binding]
608538004936	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538004937	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538004938	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
608538004939	E3 interaction surface; other site
608538004940	lipoyl attachment site [posttranslational modification]; other site
608538004941	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538004942	Outer membrane efflux protein; Region: OEP; pfam02321
608538004943	Outer membrane efflux protein; Region: OEP; pfam02321
608538004944	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
608538004945	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538004946	FeS/SAM binding site; other site
608538004947	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
608538004948	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
608538004949	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
608538004950	Protein of unknown function (DUF989); Region: DUF989; pfam06181
608538004951	Protein of unknown function (DUF461); Region: DUF461; pfam04314
608538004952	hypothetical protein; Provisional; Region: PRK00468
608538004953	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
608538004954	ribosomal protein S16; Region: S16; TIGR00002
608538004955	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
608538004956	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
608538004957	metal-binding site [ion binding]
608538004958	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538004959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538004960	motif II; other site
608538004961	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
608538004962	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
608538004963	substrate binding site [chemical binding]; other site
608538004964	active site
608538004965	catalytic residues [active]
608538004966	heterodimer interface [polypeptide binding]; other site
608538004967	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
608538004968	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
608538004969	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
608538004970	carboxyltransferase (CT) interaction site; other site
608538004971	biotinylation site [posttranslational modification]; other site
608538004972	elongation factor P; Validated; Region: PRK00529
608538004973	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
608538004974	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
608538004975	RNA binding site [nucleotide binding]; other site
608538004976	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
608538004977	RNA binding site [nucleotide binding]; other site
608538004978	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
608538004979	PBP superfamily domain; Region: PBP_like_2; cl17296
608538004980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538004981	dimer interface [polypeptide binding]; other site
608538004982	conserved gate region; other site
608538004983	putative PBP binding loops; other site
608538004984	ABC-ATPase subunit interface; other site
608538004985	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
608538004986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
608538004987	dimer interface [polypeptide binding]; other site
608538004988	conserved gate region; other site
608538004989	ABC-ATPase subunit interface; other site
608538004990	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
608538004991	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
608538004992	Walker A/P-loop; other site
608538004993	ATP binding site [chemical binding]; other site
608538004994	Q-loop/lid; other site
608538004995	ABC transporter signature motif; other site
608538004996	Walker B; other site
608538004997	D-loop; other site
608538004998	H-loop/switch region; other site
608538004999	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
608538005000	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
608538005001	Heme-binding domain of bacterial ethylbenzene dehydrogenase; Region: DOMON_EBDH; cd09623
608538005002	heme binding site [chemical binding]; other site
608538005003	beta subunit binding site [polypeptide binding]; other site
608538005004	DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478
608538005005	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
608538005006	DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479
608538005007	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538005008	molybdopterin cofactor binding site; other site
608538005009	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538005010	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
608538005011	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
608538005012	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
608538005013	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
608538005014	Walker A/P-loop; other site
608538005015	ATP binding site [chemical binding]; other site
608538005016	Q-loop/lid; other site
608538005017	ABC transporter signature motif; other site
608538005018	Walker B; other site
608538005019	D-loop; other site
608538005020	H-loop/switch region; other site
608538005021	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
608538005022	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
608538005023	FtsX-like permease family; Region: FtsX; pfam02687
608538005024	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538005025	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538005026	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538005027	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
608538005028	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
608538005029	putative active site [active]
608538005030	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
608538005031	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
608538005032	glutaminase active site [active]
608538005033	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
608538005034	dimer interface [polypeptide binding]; other site
608538005035	active site
608538005036	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
608538005037	dimer interface [polypeptide binding]; other site
608538005038	active site
608538005039	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
608538005040	Protein export membrane protein; Region: SecD_SecF; cl14618
608538005041	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
608538005042	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
608538005043	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
608538005044	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538005045	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
608538005046	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
608538005047	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
608538005048	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
608538005049	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
608538005050	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
608538005051	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
608538005052	hinge; other site
608538005053	active site
608538005054	Copper resistance protein D; Region: CopD; cl00563
608538005055	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
608538005056	Flavoprotein; Region: Flavoprotein; pfam02441
608538005057	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
608538005058	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
608538005059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538005060	active site
608538005061	motif I; other site
608538005062	motif II; other site
608538005063	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
608538005064	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
608538005065	CoA-ligase; Region: Ligase_CoA; pfam00549
608538005066	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
608538005067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005068	FeS/SAM binding site; other site
608538005069	ATP cone domain; Region: ATP-cone; pfam03477
608538005070	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
608538005071	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
608538005072	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
608538005073	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
608538005074	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538005075	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
608538005076	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
608538005077	putative active site [active]
608538005078	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
608538005079	putative active site [active]
608538005080	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
608538005081	The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763
608538005082	putative [Fe4-S4] binding site [ion binding]; other site
608538005083	putative molybdopterin cofactor binding site [chemical binding]; other site
608538005084	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
608538005085	putative molybdopterin cofactor binding site; other site
608538005086	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
608538005087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
608538005088	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
608538005089	IHF - DNA interface [nucleotide binding]; other site
608538005090	IHF dimer interface [polypeptide binding]; other site
608538005091	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
608538005092	OstA-like protein; Region: OstA; pfam03968
608538005093	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
608538005094	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
608538005095	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
608538005096	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
608538005097	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
608538005098	homotrimer interaction site [polypeptide binding]; other site
608538005099	zinc binding site [ion binding]; other site
608538005100	CDP-binding sites; other site
608538005101	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
608538005102	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
608538005103	active site
608538005104	nucleophile elbow; other site
608538005105	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
608538005106	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
608538005107	FMN-binding domain; Region: FMN_bind; pfam04205
608538005108	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
608538005109	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
608538005110	Methyltransferase domain; Region: Methyltransf_31; pfam13847
608538005111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538005112	S-adenosylmethionine binding site [chemical binding]; other site
608538005113	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
608538005114	Predicted transcriptional regulators [Transcription]; Region: COG1733
608538005115	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538005116	dimerization interface [polypeptide binding]; other site
608538005117	putative DNA binding site [nucleotide binding]; other site
608538005118	putative Zn2+ binding site [ion binding]; other site
608538005119	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
608538005120	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
608538005121	ligand binding site [chemical binding]; other site
608538005122	flexible hinge region; other site
608538005123	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
608538005124	putative switch regulator; other site
608538005125	non-specific DNA interactions [nucleotide binding]; other site
608538005126	DNA binding site [nucleotide binding]
608538005127	sequence specific DNA binding site [nucleotide binding]; other site
608538005128	putative cAMP binding site [chemical binding]; other site
608538005129	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
608538005130	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
608538005131	mce related protein; Region: MCE; pfam02470
608538005132	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
608538005133	putative active site [active]
608538005134	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
608538005135	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
608538005136	ATP binding site [chemical binding]; other site
608538005137	active site
608538005138	substrate binding site [chemical binding]; other site
608538005139	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
608538005140	Probable transposase; Region: OrfB_IS605; pfam01385
608538005141	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538005142	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538005143	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
608538005144	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
608538005145	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
608538005146	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
608538005147	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
608538005148	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
608538005149	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
608538005150	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
608538005151	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
608538005152	dimerization interface [polypeptide binding]; other site
608538005153	putative DNA binding site [nucleotide binding]; other site
608538005154	putative Zn2+ binding site [ion binding]; other site
608538005155	Low molecular weight phosphatase family; Region: LMWPc; cd00115
608538005156	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
608538005157	active site
608538005158	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
608538005159	Predicted permease; Region: DUF318; pfam03773
608538005160	arsenical pump membrane protein; Provisional; Region: PRK15445
608538005161	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
608538005162	transmembrane helices; other site
608538005163	DsrE/DsrF-like family; Region: DrsE; cl00672
608538005164	exopolyphosphatase; Region: exo_poly_only; TIGR03706
608538005165	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
608538005166	nucleotide binding site [chemical binding]; other site
608538005167	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
608538005168	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
608538005169	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538005170	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
608538005171	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538005172	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
608538005173	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
608538005174	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
608538005175	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
608538005176	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499
608538005177	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
608538005178	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
608538005179	4Fe-4S binding domain; Region: Fer4; pfam00037
608538005180	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
608538005181	oligomerisation interface [polypeptide binding]; other site
608538005182	mobile loop; other site
608538005183	roof hairpin; other site
608538005184	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
608538005185	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
608538005186	ring oligomerisation interface [polypeptide binding]; other site
608538005187	ATP/Mg binding site [chemical binding]; other site
608538005188	stacking interactions; other site
608538005189	hinge regions; other site
608538005190	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
608538005191	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
608538005192	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
608538005193	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
608538005194	catalytic residue [active]
608538005195	putative FPP diphosphate  binding site; other site
608538005196	putative FPP binding hydrophobic cleft; other site
608538005197	dimer interface [polypeptide binding]; other site
608538005198	putative IPP diphosphate binding site; other site
608538005199	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
608538005200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
608538005201	binding surface
608538005202	TPR motif; other site
608538005203	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
608538005204	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
608538005205	Cl- selectivity filter; other site
608538005206	Cl- binding residues [ion binding]; other site
608538005207	pore gating glutamate residue; other site
608538005208	dimer interface [polypeptide binding]; other site
608538005209	FOG: CBS domain [General function prediction only]; Region: COG0517
608538005210	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
608538005211	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
608538005212	FAD binding domain; Region: FAD_binding_4; pfam01565
608538005213	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
608538005214	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
608538005215	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
608538005216	ATP-grasp domain; Region: ATP-grasp_4; cl17255
608538005217	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
608538005218	cell division protein FtsA; Region: ftsA; TIGR01174
608538005219	Cell division protein FtsA; Region: FtsA; smart00842
608538005220	Cell division protein FtsA; Region: FtsA; pfam14450
608538005221	cell division protein FtsZ; Validated; Region: PRK09330
608538005222	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
608538005223	nucleotide binding site [chemical binding]; other site
608538005224	SulA interaction site; other site
608538005225	Outer membrane efflux protein; Region: OEP; pfam02321
608538005226	Outer membrane efflux protein; Region: OEP; pfam02321
608538005227	YtkA-like; Region: YtkA; pfam13115
608538005228	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
608538005229	DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; Region: DUF619-like; cl14605
608538005230	HlyD family secretion protein; Region: HlyD_3; pfam13437
608538005231	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
608538005232	NosL; Region: NosL; cl01769
608538005233	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
608538005234	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
608538005235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
608538005236	motif II; other site
608538005237	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538005238	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
608538005239	HupF/HypC family; Region: HupF_HypC; pfam01455
608538005240	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
608538005241	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
608538005242	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
608538005243	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
608538005244	putative active site [active]
608538005245	putative substrate binding site [chemical binding]; other site
608538005246	putative cosubstrate binding site; other site
608538005247	catalytic site [active]
608538005248	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
608538005249	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
608538005250	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
608538005251	substrate binding site [chemical binding]; other site
608538005252	oxyanion hole (OAH) forming residues; other site
608538005253	trimer interface [polypeptide binding]; other site
608538005254	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
608538005255	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
608538005256	Dienelactone hydrolase family; Region: DLH; pfam01738
608538005257	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
608538005258	carbon starvation protein A; Provisional; Region: PRK15015
608538005259	Carbon starvation protein CstA; Region: CstA; pfam02554
608538005260	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
608538005261	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
608538005262	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
608538005263	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
608538005264	DNA polymerase III subunit delta'; Validated; Region: PRK08485
608538005265	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
608538005266	PLD-like domain; Region: PLDc_2; pfam13091
608538005267	putative active site [active]
608538005268	catalytic site [active]
608538005269	CAAX protease self-immunity; Region: Abi; pfam02517
608538005270	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
608538005271	Cell division protein FtsA; Region: FtsA; cl17206
608538005272	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
608538005273	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
608538005274	Walker A motif; other site
608538005275	ATP binding site [chemical binding]; other site
608538005276	Walker B motif; other site
608538005277	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
608538005278	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
608538005279	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
608538005280	dimerization interface [polypeptide binding]; other site
608538005281	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
608538005282	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
608538005283	G1 box; other site
608538005284	GTP/Mg2+ binding site [chemical binding]; other site
608538005285	G2 box; other site
608538005286	Switch I region; other site
608538005287	G3 box; other site
608538005288	Switch II region; other site
608538005289	G4 box; other site
608538005290	G5 box; other site
608538005291	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
608538005292	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
608538005293	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
608538005294	dimer interface [polypeptide binding]; other site
608538005295	active site
608538005296	glycine-pyridoxal phosphate binding site [chemical binding]; other site
608538005297	folate binding site [chemical binding]; other site
608538005298	argininosuccinate lyase; Provisional; Region: PRK00855
608538005299	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
608538005300	active sites [active]
608538005301	tetramer interface [polypeptide binding]; other site
608538005302	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
608538005303	active site
608538005304	Zn binding site [ion binding]; other site
608538005305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
608538005306	Major Facilitator Superfamily; Region: MFS_1; pfam07690
608538005307	putative substrate translocation pore; other site
608538005308	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
608538005309	putative active site pocket [active]
608538005310	4-fold oligomerization interface [polypeptide binding]; other site
608538005311	metal binding residues [ion binding]; metal-binding site
608538005312	3-fold/trimer interface [polypeptide binding]; other site
608538005313	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
608538005314	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
608538005315	transcription termination factor Rho; Provisional; Region: rho; PRK09376
608538005316	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
608538005317	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
608538005318	RNA binding site [nucleotide binding]; other site
608538005319	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
608538005320	multimer interface [polypeptide binding]; other site
608538005321	Walker A motif; other site
608538005322	ATP binding site [chemical binding]; other site
608538005323	Walker B motif; other site
608538005324	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
608538005325	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
608538005326	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
608538005327	GTP/Mg2+ binding site [chemical binding]; other site
608538005328	trmE is a tRNA modification GTPase; Region: trmE; cd04164
608538005329	G1 box; other site
608538005330	G1 box; other site
608538005331	GTP/Mg2+ binding site [chemical binding]; other site
608538005332	Switch I region; other site
608538005333	Switch I region; other site
608538005334	G2 box; other site
608538005335	G2 box; other site
608538005336	Switch II region; other site
608538005337	G3 box; other site
608538005338	G3 box; other site
608538005339	Switch II region; other site
608538005340	G4 box; other site
608538005341	G5 box; other site
608538005342	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
608538005343	aminotransferase; Validated; Region: PRK08175
608538005344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
608538005345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538005346	homodimer interface [polypeptide binding]; other site
608538005347	catalytic residue [active]
608538005348	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
608538005349	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
608538005350	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
608538005351	active site
608538005352	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
608538005353	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
608538005354	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
608538005355	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
608538005356	Ligand binding site; other site
608538005357	oligomer interface; other site
608538005358	peroxiredoxin; Region: AhpC; TIGR03137
608538005359	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
608538005360	dimer interface [polypeptide binding]; other site
608538005361	decamer (pentamer of dimers) interface [polypeptide binding]; other site
608538005362	catalytic triad [active]
608538005363	peroxidatic and resolving cysteines [active]
608538005364	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
608538005365	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
608538005366	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
608538005367	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
608538005368	gamma-glutamyl kinase; Provisional; Region: PRK05429
608538005369	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
608538005370	nucleotide binding site [chemical binding]; other site
608538005371	homotetrameric interface [polypeptide binding]; other site
608538005372	putative phosphate binding site [ion binding]; other site
608538005373	putative allosteric binding site; other site
608538005374	PUA domain; Region: PUA; pfam01472
608538005375	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
608538005376	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
608538005377	putative NAD(P) binding site [chemical binding]; other site
608538005378	structural Zn binding site [ion binding]; other site
608538005379	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
608538005380	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
608538005381	motif 1; other site
608538005382	active site
608538005383	motif 2; other site
608538005384	motif 3; other site
608538005385	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
608538005386	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
608538005387	peptide chain release factor 1; Validated; Region: prfA; PRK00591
608538005388	This domain is found in peptide chain release factors; Region: PCRF; smart00937
608538005389	RF-1 domain; Region: RF-1; pfam00472
608538005390	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
608538005391	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
608538005392	RNA binding site [nucleotide binding]; other site
608538005393	active site
608538005394	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
608538005395	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
608538005396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
608538005397	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
608538005398	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
608538005399	DNA binding residues [nucleotide binding]
608538005400	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
608538005401	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
608538005402	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538005403	protein binding site [polypeptide binding]; other site
608538005404	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
608538005405	protein binding site [polypeptide binding]; other site
608538005406	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
608538005407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
608538005408	S-adenosylmethionine binding site [chemical binding]; other site
608538005409	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
608538005410	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
608538005411	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
608538005412	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
608538005413	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005414	FeS/SAM binding site; other site
608538005415	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
608538005416	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
608538005417	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
608538005418	4Fe-4S binding domain; Region: Fer4; cl02805
608538005419	Probable transposase; Region: OrfB_IS605; pfam01385
608538005420	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
608538005421	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
608538005422	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
608538005423	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
608538005424	ligand binding site [chemical binding]; other site
608538005425	NAD binding site [chemical binding]; other site
608538005426	dimerization interface [polypeptide binding]; other site
608538005427	catalytic site [active]
608538005428	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
608538005429	putative L-serine binding site [chemical binding]; other site
608538005430	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
608538005431	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
608538005432	N-acetyl-D-glucosamine binding site [chemical binding]; other site
608538005433	catalytic residue [active]
608538005434	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
608538005435	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
608538005436	active site
608538005437	PHP Thumb interface [polypeptide binding]; other site
608538005438	metal binding site [ion binding]; metal-binding site
608538005439	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
608538005440	generic binding surface I; other site
608538005441	generic binding surface II; other site
608538005442	FUN14 family; Region: FUN14; cl01015
608538005443	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
608538005444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005445	FeS/SAM binding site; other site
608538005446	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
608538005447	active site
608538005448	dimerization interface [polypeptide binding]; other site
608538005449	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
608538005450	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
608538005451	FeS/SAM binding site; other site
608538005452	glycine cleavage system protein H; Provisional; Region: PRK13380
608538005453	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538005454	lipoyl attachment site [posttranslational modification]; other site
608538005455	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
608538005456	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
608538005457	glycine cleavage system protein H; Provisional; Region: PRK13380
608538005458	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
608538005459	lipoyl attachment site [posttranslational modification]; other site
608538005460	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005461	Cysteine-rich domain; Region: CCG; pfam02754
608538005462	Cysteine-rich domain; Region: CCG; pfam02754
608538005463	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
608538005464	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
608538005465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
608538005466	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
608538005467	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005468	Cysteine-rich domain; Region: CCG; pfam02754
608538005469	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
608538005470	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
608538005471	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
608538005472	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
608538005473	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
608538005474	CPxP  motif; other site
608538005475	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
608538005476	Predicted membrane protein [Function unknown]; Region: COG1238
608538005477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
608538005478	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
608538005479	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
608538005480	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
608538005481	CoA binding domain; Region: CoA_binding; smart00881
608538005482	CoA-ligase; Region: Ligase_CoA; pfam00549
608538005483	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
608538005484	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
608538005485	CoA-ligase; Region: Ligase_CoA; pfam00549
608538005486	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
608538005487	active site
608538005488	catalytic site [active]
608538005489	substrate binding site [chemical binding]; other site
608538005490	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
608538005491	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
608538005492	HSP70 interaction site [polypeptide binding]; other site
608538005493	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
608538005494	substrate binding site [polypeptide binding]; other site
608538005495	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
608538005496	Zn binding sites [ion binding]; other site
608538005497	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
608538005498	dimer interface [polypeptide binding]; other site
608538005499	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
608538005500	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
608538005501	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
608538005502	active site
608538005503	HIGH motif; other site
608538005504	KMSK motif region; other site
608538005505	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
608538005506	tRNA binding surface [nucleotide binding]; other site
608538005507	anticodon binding site; other site
608538005508	Sporulation related domain; Region: SPOR; pfam05036
608538005509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
608538005510	binding surface
608538005511	TPR motif; other site
608538005512	TPR repeat; Region: TPR_11; pfam13414
608538005513	Sporulation related domain; Region: SPOR; pfam05036
608538005514	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
608538005515	Methyltransferase domain; Region: Methyltransf_26; pfam13659
608538005516	S-adenosylmethionine binding site [chemical binding]; other site
608538005517	Uncharacterized conserved protein [Function unknown]; Region: COG1656
608538005518	Protein of unknown function DUF82; Region: DUF82; pfam01927
608538005519	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
608538005520	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
608538005521	substrate binding site [chemical binding]; other site
608538005522	ligand binding site [chemical binding]; other site
608538005523	FtsH Extracellular; Region: FtsH_ext; pfam06480
608538005524	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
608538005525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
608538005526	Walker A motif; other site
608538005527	ATP binding site [chemical binding]; other site
608538005528	Walker B motif; other site
608538005529	arginine finger; other site
608538005530	Peptidase family M41; Region: Peptidase_M41; pfam01434
608538005531	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
608538005532	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
608538005533	Ligand Binding Site [chemical binding]; other site
608538005534	SapC; Region: SapC; pfam07277
608538005535	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
608538005536	Glycoprotease family; Region: Peptidase_M22; pfam00814
608538005537	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
608538005538	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
608538005539	inhibitor-cofactor binding pocket; inhibition site
608538005540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
608538005541	catalytic residue [active]
608538005542	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
608538005543	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
608538005544	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
608538005545	molybdopterin cofactor binding site; other site
608538005546	Competence-damaged protein; Region: CinA; pfam02464
608538005547	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
608538005548	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
608538005549	active site
608538005550	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
608538005551	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
608538005552	Substrate binding site; other site
608538005553	Mg++ binding site; other site
608538005554	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
608538005555	active site
608538005556	substrate binding site [chemical binding]; other site
608538005557	CoA binding site [chemical binding]; other site
608538005558	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
608538005559	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
608538005560	Superfamily II helicase [General function prediction only]; Region: COG1204
608538005561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
608538005562	ATP binding site [chemical binding]; other site
608538005563	putative Mg++ binding site [ion binding]; other site
608538005564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
608538005565	nucleotide binding region [chemical binding]; other site
608538005566	ATP-binding site [chemical binding]; other site
608538005567	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
608538005568	glutamate racemase; Provisional; Region: PRK00865
608538005569	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
608538005570	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
608538005571	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
608538005572	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878