-- dump date 20140619_115537 -- class Genbank::misc_feature -- table misc_feature_note -- id note 717785000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 717785000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 717785000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785000004 Walker A motif; other site 717785000005 ATP binding site [chemical binding]; other site 717785000006 Walker B motif; other site 717785000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 717785000008 DnaA box-binding interface [nucleotide binding]; other site 717785000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 717785000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 717785000011 putative DNA binding surface [nucleotide binding]; other site 717785000012 dimer interface [polypeptide binding]; other site 717785000013 beta-clamp/clamp loader binding surface; other site 717785000014 beta-clamp/translesion DNA polymerase binding surface; other site 717785000015 recombination protein F; Reviewed; Region: recF; PRK00064 717785000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785000017 Walker A/P-loop; other site 717785000018 ATP binding site [chemical binding]; other site 717785000019 Q-loop/lid; other site 717785000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785000021 ABC transporter signature motif; other site 717785000022 Walker B; other site 717785000023 D-loop; other site 717785000024 H-loop/switch region; other site 717785000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 717785000026 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717785000027 Mg2+ binding site [ion binding]; other site 717785000028 G-X-G motif; other site 717785000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 717785000030 anchoring element; other site 717785000031 dimer interface [polypeptide binding]; other site 717785000032 ATP binding site [chemical binding]; other site 717785000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 717785000034 active site 717785000035 putative metal-binding site [ion binding]; other site 717785000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717785000037 putative cation:proton antiport protein; Provisional; Region: PRK10669 717785000038 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 717785000039 TrkA-N domain; Region: TrkA_N; pfam02254 717785000040 Transglycosylase; Region: Transgly; pfam00912 717785000041 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 717785000042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 717785000043 Protein of unknown function DUF45; Region: DUF45; pfam01863 717785000044 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 717785000045 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785000046 Cu(I) binding site [ion binding]; other site 717785000047 MAPEG family; Region: MAPEG; cl09190 717785000048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785000049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785000050 ATP binding site [chemical binding]; other site 717785000051 Mg2+ binding site [ion binding]; other site 717785000052 G-X-G motif; other site 717785000053 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 717785000054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785000055 active site 717785000056 phosphorylation site [posttranslational modification] 717785000057 intermolecular recognition site; other site 717785000058 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 717785000059 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 717785000060 AAA domain; Region: AAA_32; pfam13654 717785000061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785000062 Walker A motif; other site 717785000063 ATP binding site [chemical binding]; other site 717785000064 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 717785000065 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 717785000066 GcrA cell cycle regulator; Region: GcrA; cl11564 717785000067 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 717785000068 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785000069 inhibitor-cofactor binding pocket; inhibition site 717785000070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000071 catalytic residue [active] 717785000072 ornithine carbamoyltransferase; Provisional; Region: PRK00779 717785000073 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785000074 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785000075 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 717785000076 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 717785000077 dimerization interface [polypeptide binding]; other site 717785000078 domain crossover interface; other site 717785000079 redox-dependent activation switch; other site 717785000080 EF-hand domain pair; Region: EF_hand_5; pfam13499 717785000081 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 717785000082 Ca2+ binding site [ion binding]; other site 717785000083 acetylornithine deacetylase; Provisional; Region: PRK07522 717785000084 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 717785000085 metal binding site [ion binding]; metal-binding site 717785000086 putative dimer interface [polypeptide binding]; other site 717785000087 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 717785000088 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 717785000089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785000090 homodimer interface [polypeptide binding]; other site 717785000091 substrate-cofactor binding pocket; other site 717785000092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000093 catalytic residue [active] 717785000094 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 717785000095 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 717785000096 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 717785000097 trimer interface [polypeptide binding]; other site 717785000098 active site 717785000099 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 717785000100 trimer interface [polypeptide binding]; other site 717785000101 active site 717785000102 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 717785000103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785000104 dimerization interface [polypeptide binding]; other site 717785000105 putative DNA binding site [nucleotide binding]; other site 717785000106 putative Zn2+ binding site [ion binding]; other site 717785000107 short chain dehydrogenase; Provisional; Region: PRK12747 717785000108 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 717785000109 NADP binding site [chemical binding]; other site 717785000110 homodimer interface [polypeptide binding]; other site 717785000111 active site 717785000112 substrate binding site [chemical binding]; other site 717785000113 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 717785000114 IHF dimer interface [polypeptide binding]; other site 717785000115 IHF - DNA interface [nucleotide binding]; other site 717785000116 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 717785000117 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 717785000118 metal binding site [ion binding]; metal-binding site 717785000119 dimer interface [polypeptide binding]; other site 717785000120 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 717785000121 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 717785000122 trimer interface [polypeptide binding]; other site 717785000123 active site 717785000124 substrate binding site [chemical binding]; other site 717785000125 CoA binding site [chemical binding]; other site 717785000126 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 717785000127 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 717785000128 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785000129 catalytic residues [active] 717785000130 argininosuccinate lyase; Provisional; Region: PRK00855 717785000131 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 717785000132 active sites [active] 717785000133 tetramer interface [polypeptide binding]; other site 717785000134 diaminopimelate decarboxylase; Region: lysA; TIGR01048 717785000135 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 717785000136 active site 717785000137 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785000138 substrate binding site [chemical binding]; other site 717785000139 catalytic residues [active] 717785000140 dimer interface [polypeptide binding]; other site 717785000141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785000142 PAS fold; Region: PAS_4; pfam08448 717785000143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785000144 putative active site [active] 717785000145 heme pocket [chemical binding]; other site 717785000146 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 717785000147 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 717785000148 epsilon subunit interface [polypeptide binding]; other site 717785000149 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785000150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785000151 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 717785000152 dimerization interface [polypeptide binding]; other site 717785000153 substrate binding pocket [chemical binding]; other site 717785000154 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 717785000155 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 717785000156 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 717785000157 Transglycosylase; Region: Transgly; pfam00912 717785000158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 717785000159 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 717785000160 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 717785000161 MG2 domain; Region: A2M_N; pfam01835 717785000162 Alpha-2-macroglobulin family; Region: A2M; pfam00207 717785000163 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 717785000164 surface patch; other site 717785000165 thioester region; other site 717785000166 specificity defining residues; other site 717785000167 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 717785000168 Transglycosylase; Region: Transgly; cl17702 717785000169 Domain of unknown function DUF87; Region: DUF87; pfam01935 717785000170 AAA-like domain; Region: AAA_10; pfam12846 717785000171 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 717785000172 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 717785000173 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717785000174 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717785000175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785000176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000177 putative substrate translocation pore; other site 717785000178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785000179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785000180 active site 717785000181 catalytic tetrad [active] 717785000182 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 717785000183 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785000184 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 717785000185 dimer interface [polypeptide binding]; other site 717785000186 active site 717785000187 lytic murein transglycosylase; Region: MltB_2; TIGR02283 717785000188 murein hydrolase B; Provisional; Region: PRK10760; cl17906 717785000189 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 717785000190 active site 717785000191 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 717785000192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785000193 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785000194 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785000195 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000196 ligand binding site [chemical binding]; other site 717785000197 flexible hinge region; other site 717785000198 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 717785000199 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 717785000200 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 717785000201 Putative phosphatase (DUF442); Region: DUF442; cl17385 717785000202 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 717785000203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785000204 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 717785000205 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 717785000206 active site 717785000207 TDP-binding site; other site 717785000208 acceptor substrate-binding pocket; other site 717785000209 homodimer interface [polypeptide binding]; other site 717785000210 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 717785000211 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 717785000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000213 metabolite-proton symporter; Region: 2A0106; TIGR00883 717785000214 putative substrate translocation pore; other site 717785000215 Protein of unknown function (DUF640); Region: DUF640; pfam04852 717785000216 Putative phosphatase (DUF442); Region: DUF442; cl17385 717785000217 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 717785000218 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 717785000219 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 717785000220 B12 binding site [chemical binding]; other site 717785000221 cobalt ligand [ion binding]; other site 717785000222 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 717785000223 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 717785000224 NAD(P) binding site [chemical binding]; other site 717785000225 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 717785000226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785000227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785000228 active site 717785000229 META domain; Region: META; pfam03724 717785000230 short chain dehydrogenase; Provisional; Region: PRK05993 717785000231 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785000232 NADP binding site [chemical binding]; other site 717785000233 active site 717785000234 steroid binding site; other site 717785000235 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 717785000236 putative active site [active] 717785000237 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 717785000238 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 717785000239 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 717785000240 active site 717785000241 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 717785000242 (T/H)XGH motif; other site 717785000243 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 717785000244 putative catalytic cysteine [active] 717785000245 gamma-glutamyl kinase; Provisional; Region: PRK05429 717785000246 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 717785000247 nucleotide binding site [chemical binding]; other site 717785000248 homotetrameric interface [polypeptide binding]; other site 717785000249 putative phosphate binding site [ion binding]; other site 717785000250 putative allosteric binding site; other site 717785000251 PUA domain; Region: PUA; pfam01472 717785000252 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 717785000253 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717785000254 GTPase CgtA; Reviewed; Region: obgE; PRK12299 717785000255 GTP1/OBG; Region: GTP1_OBG; pfam01018 717785000256 Obg GTPase; Region: Obg; cd01898 717785000257 G1 box; other site 717785000258 GTP/Mg2+ binding site [chemical binding]; other site 717785000259 Switch I region; other site 717785000260 G2 box; other site 717785000261 G3 box; other site 717785000262 Switch II region; other site 717785000263 G4 box; other site 717785000264 G5 box; other site 717785000265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 717785000266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 717785000267 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 717785000268 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 717785000269 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 717785000270 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 717785000271 TIR domain; Region: TIR_2; pfam13676 717785000272 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 717785000273 AAA domain; Region: AAA_21; pfam13304 717785000274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785000275 ABC transporter signature motif; other site 717785000276 Walker B; other site 717785000277 D-loop; other site 717785000278 H-loop/switch region; other site 717785000279 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785000280 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785000281 catalytic residues [active] 717785000282 catalytic nucleophile [active] 717785000283 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785000284 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785000285 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785000286 Synaptic Site I dimer interface [polypeptide binding]; other site 717785000287 DNA binding site [nucleotide binding] 717785000288 Recombinase; Region: Recombinase; pfam07508 717785000289 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785000290 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785000291 Predicted membrane protein [Function unknown]; Region: COG3059 717785000292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785000293 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 717785000294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785000295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000296 dimerization interface [polypeptide binding]; other site 717785000297 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 717785000298 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 717785000299 putative NAD(P) binding site [chemical binding]; other site 717785000300 dimer interface [polypeptide binding]; other site 717785000301 Cupin domain; Region: Cupin_2; pfam07883 717785000302 Domain of unknown function (DUF336); Region: DUF336; pfam03928 717785000303 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 717785000304 Major royal jelly protein; Region: MRJP; pfam03022 717785000305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000306 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785000307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785000309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785000310 DNA binding residues [nucleotide binding] 717785000311 dimerization interface [polypeptide binding]; other site 717785000312 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 717785000313 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785000314 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 717785000315 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000316 active site 717785000317 dimer interface [polypeptide binding]; other site 717785000318 non-prolyl cis peptide bond; other site 717785000319 insertion regions; other site 717785000320 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 717785000321 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 717785000322 Flavin binding site [chemical binding]; other site 717785000323 Amino acid permease; Region: AA_permease_2; pfam13520 717785000324 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785000325 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785000326 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785000327 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 717785000328 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000329 active site 717785000330 dimer interface [polypeptide binding]; other site 717785000331 non-prolyl cis peptide bond; other site 717785000332 insertion regions; other site 717785000333 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 717785000334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785000335 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 717785000336 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785000337 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785000338 catalytic residues [active] 717785000339 catalytic nucleophile [active] 717785000340 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785000341 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785000342 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785000343 Synaptic Site I dimer interface [polypeptide binding]; other site 717785000344 DNA binding site [nucleotide binding] 717785000345 Recombinase; Region: Recombinase; pfam07508 717785000346 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785000347 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785000348 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785000349 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785000350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785000351 catalytic residue [active] 717785000352 serine O-acetyltransferase; Region: cysE; TIGR01172 717785000353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 717785000354 trimer interface [polypeptide binding]; other site 717785000355 active site 717785000356 substrate binding site [chemical binding]; other site 717785000357 CoA binding site [chemical binding]; other site 717785000358 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 717785000359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 717785000360 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785000361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785000362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000363 dimerization interface [polypeptide binding]; other site 717785000364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785000365 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 717785000366 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785000367 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000368 Walker A/P-loop; other site 717785000369 ATP binding site [chemical binding]; other site 717785000370 Q-loop/lid; other site 717785000371 ABC transporter signature motif; other site 717785000372 Walker B; other site 717785000373 D-loop; other site 717785000374 H-loop/switch region; other site 717785000375 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785000377 dimer interface [polypeptide binding]; other site 717785000378 conserved gate region; other site 717785000379 putative PBP binding loops; other site 717785000380 ABC-ATPase subunit interface; other site 717785000381 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 717785000382 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000383 active site 717785000384 dimer interface [polypeptide binding]; other site 717785000385 non-prolyl cis peptide bond; other site 717785000386 insertion regions; other site 717785000387 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785000388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785000389 substrate binding pocket [chemical binding]; other site 717785000390 membrane-bound complex binding site; other site 717785000391 hinge residues; other site 717785000392 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 717785000393 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785000394 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785000395 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785000396 inhibitor site; inhibition site 717785000397 active site 717785000398 dimer interface [polypeptide binding]; other site 717785000399 catalytic residue [active] 717785000400 benzoate transport; Region: 2A0115; TIGR00895 717785000401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000402 putative substrate translocation pore; other site 717785000403 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000404 active site 717785000405 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 717785000406 dimer interface [polypeptide binding]; other site 717785000407 non-prolyl cis peptide bond; other site 717785000408 insertion regions; other site 717785000409 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785000410 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785000411 active site 717785000412 non-prolyl cis peptide bond; other site 717785000413 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 717785000414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785000415 substrate binding site [chemical binding]; other site 717785000416 oxyanion hole (OAH) forming residues; other site 717785000417 trimer interface [polypeptide binding]; other site 717785000418 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785000419 Transcriptional regulator; Region: Rrf2; pfam02082 717785000420 oxidoreductase; Provisional; Region: PRK06196 717785000421 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 717785000422 putative NAD(P) binding site [chemical binding]; other site 717785000423 active site 717785000424 Cupin; Region: Cupin_6; pfam12852 717785000425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785000426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785000428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785000429 active site 717785000430 catalytic tetrad [active] 717785000431 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717785000432 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 717785000433 TM-ABC transporter signature motif; other site 717785000434 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 717785000435 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 717785000436 Walker A/P-loop; other site 717785000437 ATP binding site [chemical binding]; other site 717785000438 Q-loop/lid; other site 717785000439 ABC transporter signature motif; other site 717785000440 Walker B; other site 717785000441 D-loop; other site 717785000442 H-loop/switch region; other site 717785000443 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 717785000444 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 717785000445 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 717785000446 ligand binding site [chemical binding]; other site 717785000447 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785000448 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 717785000449 XdhC Rossmann domain; Region: XdhC_C; pfam13478 717785000450 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 717785000451 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 717785000452 active site 717785000453 metal binding site [ion binding]; metal-binding site 717785000454 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 717785000455 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785000456 metal ion-dependent adhesion site (MIDAS); other site 717785000457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785000458 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 717785000459 Walker A motif; other site 717785000460 ATP binding site [chemical binding]; other site 717785000461 Walker B motif; other site 717785000462 arginine finger; other site 717785000463 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785000464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785000465 catalytic loop [active] 717785000466 iron binding site [ion binding]; other site 717785000467 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785000468 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785000469 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 717785000470 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000471 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785000472 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000473 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 717785000474 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 717785000475 hypothetical protein; Provisional; Region: PRK07236 717785000476 hypothetical protein; Provisional; Region: PRK07236 717785000477 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 717785000478 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 717785000479 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785000480 homotrimer interaction site [polypeptide binding]; other site 717785000481 putative active site [active] 717785000482 Transcriptional regulator [Transcription]; Region: IclR; COG1414 717785000483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785000484 putative DNA binding site [nucleotide binding]; other site 717785000485 putative Zn2+ binding site [ion binding]; other site 717785000486 Bacterial transcriptional regulator; Region: IclR; pfam01614 717785000487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000488 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 717785000489 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785000490 XdhC Rossmann domain; Region: XdhC_C; pfam13478 717785000491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785000492 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 717785000493 Walker A/P-loop; other site 717785000494 ATP binding site [chemical binding]; other site 717785000495 Q-loop/lid; other site 717785000496 ABC transporter signature motif; other site 717785000497 Walker B; other site 717785000498 D-loop; other site 717785000499 H-loop/switch region; other site 717785000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785000501 dimer interface [polypeptide binding]; other site 717785000502 conserved gate region; other site 717785000503 ABC-ATPase subunit interface; other site 717785000504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785000505 dimer interface [polypeptide binding]; other site 717785000506 conserved gate region; other site 717785000507 putative PBP binding loops; other site 717785000508 ABC-ATPase subunit interface; other site 717785000509 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 717785000510 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 717785000511 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785000512 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785000513 NAD(P) binding site [chemical binding]; other site 717785000514 catalytic residues [active] 717785000515 choline dehydrogenase; Validated; Region: PRK02106 717785000516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785000517 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000518 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000519 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785000520 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000521 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000522 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785000523 Cytochrome c; Region: Cytochrom_C; pfam00034 717785000524 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785000525 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 717785000526 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785000527 FAD binding domain; Region: FAD_binding_3; pfam01494 717785000528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000529 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 717785000530 Isochorismatase family; Region: Isochorismatase; pfam00857 717785000531 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 717785000532 catalytic triad [active] 717785000533 substrate binding site [chemical binding]; other site 717785000534 domain interfaces; other site 717785000535 conserved cis-peptide bond; other site 717785000536 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 717785000537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785000538 MarR family; Region: MarR_2; pfam12802 717785000539 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785000540 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785000541 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 717785000542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785000543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785000544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000545 dimerization interface [polypeptide binding]; other site 717785000546 short chain dehydrogenase; Provisional; Region: PRK06500 717785000547 classical (c) SDRs; Region: SDR_c; cd05233 717785000548 NAD(P) binding site [chemical binding]; other site 717785000549 active site 717785000550 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 717785000551 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 717785000552 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785000553 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 717785000554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 717785000555 DEAD-like helicases superfamily; Region: DEXDc; smart00487 717785000556 ATP binding site [chemical binding]; other site 717785000557 putative Mg++ binding site [ion binding]; other site 717785000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785000559 nucleotide binding region [chemical binding]; other site 717785000560 ATP-binding site [chemical binding]; other site 717785000561 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 717785000562 RNA binding site [nucleotide binding]; other site 717785000563 Signal recognition particle, alpha subunit, N-terminal; Region: SRP-alpha_N; pfam04086 717785000564 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 717785000565 DNA binding residues [nucleotide binding] 717785000566 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 717785000567 dimer interface [polypeptide binding]; other site 717785000568 putative metal binding site [ion binding]; other site 717785000569 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 717785000570 LTXXQ motif family protein; Region: LTXXQ; pfam07813 717785000571 Rhabdovirus spike glycoprotein; Region: Rhabdo_glycop; pfam00974 717785000572 Short C-terminal domain; Region: SHOCT; pfam09851 717785000573 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785000574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785000576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000577 ligand binding site [chemical binding]; other site 717785000578 flexible hinge region; other site 717785000579 putative switch regulator; other site 717785000580 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 717785000581 non-specific DNA interactions [nucleotide binding]; other site 717785000582 DNA binding site [nucleotide binding] 717785000583 sequence specific DNA binding site [nucleotide binding]; other site 717785000584 putative cAMP binding site [chemical binding]; other site 717785000585 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 717785000586 heme-binding site [chemical binding]; other site 717785000587 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 717785000588 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 717785000589 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785000590 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785000591 inhibitor site; inhibition site 717785000592 active site 717785000593 dimer interface [polypeptide binding]; other site 717785000594 catalytic residue [active] 717785000595 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 717785000596 intersubunit interface [polypeptide binding]; other site 717785000597 active site 717785000598 Zn2+ binding site [ion binding]; other site 717785000599 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000601 DNA-binding site [nucleotide binding]; DNA binding site 717785000602 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785000603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785000604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000605 homodimer interface [polypeptide binding]; other site 717785000606 catalytic residue [active] 717785000607 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 717785000608 active site 717785000609 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 717785000610 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785000611 active site 717785000612 substrate binding site [chemical binding]; other site 717785000613 ATP binding site [chemical binding]; other site 717785000614 activation loop (A-loop); other site 717785000615 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785000616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000617 DNA-binding site [nucleotide binding]; DNA binding site 717785000618 FCD domain; Region: FCD; pfam07729 717785000619 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 717785000620 L-aspartate oxidase; Provisional; Region: PRK06175 717785000621 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 717785000622 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 717785000623 Ferredoxin [Energy production and conversion]; Region: COG1146 717785000624 4Fe-4S binding domain; Region: Fer4; cl02805 717785000625 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 717785000626 Creatinine amidohydrolase; Region: Creatininase; pfam02633 717785000627 ferredoxin-NADP+ reductase; Region: PLN02852 717785000628 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785000629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785000630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785000631 catalytic residue [active] 717785000632 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 717785000633 putative hydrophobic ligand binding site [chemical binding]; other site 717785000634 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000635 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785000636 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000637 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785000638 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 717785000639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785000640 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785000641 catalytic loop [active] 717785000642 iron binding site [ion binding]; other site 717785000643 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785000644 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785000645 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785000647 dimer interface [polypeptide binding]; other site 717785000648 conserved gate region; other site 717785000649 putative PBP binding loops; other site 717785000650 ABC-ATPase subunit interface; other site 717785000651 NMT1/THI5 like; Region: NMT1; pfam09084 717785000652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785000653 membrane-bound complex binding site; other site 717785000654 hinge residues; other site 717785000655 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785000656 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000657 Walker A/P-loop; other site 717785000658 ATP binding site [chemical binding]; other site 717785000659 Q-loop/lid; other site 717785000660 ABC transporter signature motif; other site 717785000661 Walker B; other site 717785000662 D-loop; other site 717785000663 H-loop/switch region; other site 717785000664 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 717785000665 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785000666 NAD binding site [chemical binding]; other site 717785000667 catalytic residues [active] 717785000668 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785000669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000670 DNA-binding site [nucleotide binding]; DNA binding site 717785000671 FCD domain; Region: FCD; pfam07729 717785000672 Amino acid synthesis; Region: AA_synth; pfam06684 717785000673 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 717785000674 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 717785000675 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 717785000676 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785000677 NMT1-like family; Region: NMT1_2; pfam13379 717785000678 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 717785000679 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785000680 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000681 Walker A/P-loop; other site 717785000682 ATP binding site [chemical binding]; other site 717785000683 Q-loop/lid; other site 717785000684 ABC transporter signature motif; other site 717785000685 Walker B; other site 717785000686 D-loop; other site 717785000687 H-loop/switch region; other site 717785000688 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785000690 dimer interface [polypeptide binding]; other site 717785000691 conserved gate region; other site 717785000692 putative PBP binding loops; other site 717785000693 ABC-ATPase subunit interface; other site 717785000694 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 717785000695 Flavoprotein; Region: Flavoprotein; pfam02441 717785000696 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 717785000697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785000698 MarR family; Region: MarR_2; pfam12802 717785000699 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785000700 Amidohydrolase; Region: Amidohydro_5; pfam13594 717785000701 Amidohydrolase; Region: Amidohydro_4; pfam13147 717785000702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 717785000703 active site 717785000704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 717785000705 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 717785000706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000707 D-galactonate transporter; Region: 2A0114; TIGR00893 717785000708 putative substrate translocation pore; other site 717785000709 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785000710 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 717785000711 active site 717785000712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785000713 MarR family; Region: MarR_2; pfam12802 717785000714 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 717785000715 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 717785000716 active site 717785000717 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 717785000718 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785000719 N-terminal plug; other site 717785000720 ligand-binding site [chemical binding]; other site 717785000721 alpha/beta hydrolase fold protein (pseudogene);Evidence 7 : Gene remnant 717785000722 Evidence 7 : Gene remnant 717785000723 Evidence 7 : Gene remnant 717785000724 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717785000725 Cation efflux family; Region: Cation_efflux; pfam01545 717785000726 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 717785000727 Found in ATP-dependent protease La (LON); Region: LON; smart00464 717785000728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785000729 Walker A motif; other site 717785000730 ATP binding site [chemical binding]; other site 717785000731 Walker B motif; other site 717785000732 arginine finger; other site 717785000733 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717785000734 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785000735 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 717785000736 putative dimer interface [polypeptide binding]; other site 717785000737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 717785000738 CreA protein; Region: CreA; pfam05981 717785000739 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 717785000740 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 717785000741 putative molybdopterin cofactor binding site [chemical binding]; other site 717785000742 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 717785000743 putative molybdopterin cofactor binding site; other site 717785000744 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 717785000745 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 717785000746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 717785000747 GAF domain; Region: GAF; pfam01590 717785000748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785000749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785000750 metal binding site [ion binding]; metal-binding site 717785000751 active site 717785000752 I-site; other site 717785000753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785000754 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785000755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785000756 S-adenosylmethionine binding site [chemical binding]; other site 717785000757 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 717785000758 CoA-transferase family III; Region: CoA_transf_3; pfam02515 717785000759 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 717785000760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785000761 FAD binding site [chemical binding]; other site 717785000762 substrate binding pocket [chemical binding]; other site 717785000763 catalytic base [active] 717785000764 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 717785000765 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 717785000766 catalytic triad [active] 717785000767 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 717785000768 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 717785000769 nudix motif; other site 717785000770 salicylate hydroxylase; Provisional; Region: PRK08163 717785000771 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785000772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 717785000773 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 717785000774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000775 nucleophilic elbow; other site 717785000776 catalytic triad; other site 717785000777 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785000778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785000779 WHG domain; Region: WHG; pfam13305 717785000780 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 717785000781 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 717785000782 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 717785000783 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 717785000784 putative metal binding site [ion binding]; other site 717785000785 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785000786 HSP70 interaction site [polypeptide binding]; other site 717785000787 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 717785000788 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 717785000789 amidase catalytic site [active] 717785000790 Zn binding residues [ion binding]; other site 717785000791 substrate binding site [chemical binding]; other site 717785000792 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785000793 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 717785000794 Sulfatase; Region: Sulfatase; pfam00884 717785000795 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785000796 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000798 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785000799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000801 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 717785000802 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 717785000803 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 717785000804 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 717785000805 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785000806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000808 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 717785000809 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 717785000810 cell division protein MraZ; Reviewed; Region: PRK00326 717785000811 MraZ protein; Region: MraZ; pfam02381 717785000812 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 717785000813 MraW methylase family; Region: Methyltransf_5; cl17771 717785000814 Cell division protein FtsL; Region: FtsL; cl11433 717785000815 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 717785000816 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 717785000817 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 717785000818 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 717785000819 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000820 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000821 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000822 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 717785000823 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000826 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 717785000827 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 717785000828 Mg++ binding site [ion binding]; other site 717785000829 putative catalytic motif [active] 717785000830 putative substrate binding site [chemical binding]; other site 717785000831 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 717785000832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000834 cell division protein FtsW; Region: ftsW; TIGR02614 717785000835 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 717785000836 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 717785000837 active site 717785000838 homodimer interface [polypeptide binding]; other site 717785000839 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 717785000840 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000843 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 717785000844 FAD binding domain; Region: FAD_binding_4; pfam01565 717785000845 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 717785000846 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 717785000847 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 717785000848 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785000849 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 717785000850 Cell division protein FtsQ; Region: FtsQ; pfam03799 717785000851 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 717785000852 Cell division protein FtsA; Region: FtsA; smart00842 717785000853 Cell division protein FtsA; Region: FtsA; pfam14450 717785000854 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 717785000855 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 717785000856 nucleotide binding site [chemical binding]; other site 717785000857 SulA interaction site; other site 717785000858 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 717785000859 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 717785000860 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 717785000861 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 717785000862 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 717785000863 nucleotide binding pocket [chemical binding]; other site 717785000864 K-X-D-G motif; other site 717785000865 catalytic site [active] 717785000866 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 717785000867 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 717785000868 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 717785000869 Dimer interface [polypeptide binding]; other site 717785000870 BRCT sequence motif; other site 717785000871 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 717785000872 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 717785000873 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 717785000874 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 717785000875 active site 717785000876 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 717785000877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785000878 S-adenosylmethionine binding site [chemical binding]; other site 717785000879 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 717785000880 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785000881 HSP70 interaction site [polypeptide binding]; other site 717785000882 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 717785000883 Part of AAA domain; Region: AAA_19; pfam13245 717785000884 Family description; Region: UvrD_C_2; pfam13538 717785000885 AsmA family; Region: AsmA; pfam05170 717785000886 GTP-binding protein LepA; Provisional; Region: PRK05433 717785000887 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 717785000888 G1 box; other site 717785000889 putative GEF interaction site [polypeptide binding]; other site 717785000890 GTP/Mg2+ binding site [chemical binding]; other site 717785000891 Switch I region; other site 717785000892 G2 box; other site 717785000893 G3 box; other site 717785000894 Switch II region; other site 717785000895 G4 box; other site 717785000896 G5 box; other site 717785000897 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 717785000898 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 717785000899 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 717785000900 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 717785000901 diiron binding motif [ion binding]; other site 717785000902 Uncharacterized conserved protein [Function unknown]; Region: COG1633 717785000903 CCC1-related protein family; Region: CCC1_like_1; cd02437 717785000904 Transglycosylase SLT domain; Region: SLT_2; pfam13406 717785000905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 717785000906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 717785000907 catalytic residue [active] 717785000908 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785000909 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 717785000910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785000911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785000912 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 717785000913 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 717785000914 putative tRNA-binding site [nucleotide binding]; other site 717785000915 B3/4 domain; Region: B3_4; pfam03483 717785000916 tRNA synthetase B5 domain; Region: B5; smart00874 717785000917 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 717785000918 dimer interface [polypeptide binding]; other site 717785000919 motif 1; other site 717785000920 motif 3; other site 717785000921 motif 2; other site 717785000922 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 717785000923 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 717785000924 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 717785000925 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 717785000926 dimer interface [polypeptide binding]; other site 717785000927 motif 1; other site 717785000928 active site 717785000929 motif 2; other site 717785000930 motif 3; other site 717785000931 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 717785000932 23S rRNA binding site [nucleotide binding]; other site 717785000933 L21 binding site [polypeptide binding]; other site 717785000934 L13 binding site [polypeptide binding]; other site 717785000935 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 717785000936 Predicted membrane protein [Function unknown]; Region: COG2246 717785000937 GtrA-like protein; Region: GtrA; pfam04138 717785000938 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785000939 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000940 ligand binding site [chemical binding]; other site 717785000941 flexible hinge region; other site 717785000942 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 717785000943 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 717785000944 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 717785000945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785000946 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 717785000947 putative ADP-binding pocket [chemical binding]; other site 717785000948 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785000949 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785000950 putative metal binding site; other site 717785000951 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000952 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 717785000953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785000954 putative NAD(P) binding site [chemical binding]; other site 717785000955 epoxyqueuosine reductase; Region: TIGR00276 717785000956 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 717785000957 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 717785000958 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785000959 C-terminal domain interface [polypeptide binding]; other site 717785000960 GSH binding site (G-site) [chemical binding]; other site 717785000961 dimer interface [polypeptide binding]; other site 717785000962 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 717785000963 N-terminal domain interface [polypeptide binding]; other site 717785000964 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 717785000965 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 717785000966 active site 717785000967 phosphorylation site [posttranslational modification] 717785000968 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 717785000969 30S subunit binding site; other site 717785000970 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 717785000971 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 717785000972 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 717785000973 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 717785000974 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 717785000975 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 717785000976 Walker A/P-loop; other site 717785000977 ATP binding site [chemical binding]; other site 717785000978 Q-loop/lid; other site 717785000979 ABC transporter signature motif; other site 717785000980 Walker B; other site 717785000981 D-loop; other site 717785000982 H-loop/switch region; other site 717785000983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 717785000984 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 717785000985 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 717785000986 OstA-like protein; Region: OstA; cl00844 717785000987 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 717785000988 OstA-like protein; Region: OstA; pfam03968 717785000989 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 717785000990 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 717785000991 catalytic site [active] 717785000992 putative active site [active] 717785000993 putative substrate binding site [chemical binding]; other site 717785000994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785000996 putative substrate translocation pore; other site 717785000997 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 717785000998 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785000999 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785001000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001002 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 717785001003 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785001004 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785001005 E3 interaction surface; other site 717785001006 lipoyl attachment site [posttranslational modification]; other site 717785001007 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785001008 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785001009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785001010 putative substrate translocation pore; other site 717785001011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785001012 benzoate transport; Region: 2A0115; TIGR00895 717785001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785001014 putative substrate translocation pore; other site 717785001015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785001016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785001017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785001018 active site 717785001019 catalytic tetrad [active] 717785001020 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 717785001021 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 717785001022 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 717785001023 Isochorismatase family; Region: Isochorismatase; pfam00857 717785001024 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785001025 catalytic triad [active] 717785001026 conserved cis-peptide bond; other site 717785001027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001029 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 717785001030 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 717785001031 cobalamin binding residues [chemical binding]; other site 717785001032 putative BtuC binding residues; other site 717785001033 dimer interface [polypeptide binding]; other site 717785001034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 717785001035 MOSC domain; Region: MOSC; pfam03473 717785001036 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785001037 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785001038 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 717785001039 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785001040 Walker A/P-loop; other site 717785001041 ATP binding site [chemical binding]; other site 717785001042 Q-loop/lid; other site 717785001043 ABC transporter signature motif; other site 717785001044 Walker B; other site 717785001045 D-loop; other site 717785001046 H-loop/switch region; other site 717785001047 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785001048 Walker A/P-loop; other site 717785001049 ATP binding site [chemical binding]; other site 717785001050 Q-loop/lid; other site 717785001051 ABC transporter signature motif; other site 717785001052 Walker B; other site 717785001053 D-loop; other site 717785001054 H-loop/switch region; other site 717785001055 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717785001056 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785001057 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 717785001058 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785001059 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717785001060 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785001061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785001062 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785001063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785001064 Walker A/P-loop; other site 717785001065 ATP binding site [chemical binding]; other site 717785001066 Q-loop/lid; other site 717785001067 ABC transporter signature motif; other site 717785001068 Walker B; other site 717785001069 D-loop; other site 717785001070 H-loop/switch region; other site 717785001071 TOBE domain; Region: TOBE_2; pfam08402 717785001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001073 dimer interface [polypeptide binding]; other site 717785001074 conserved gate region; other site 717785001075 putative PBP binding loops; other site 717785001076 ABC-ATPase subunit interface; other site 717785001077 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785001078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001079 dimer interface [polypeptide binding]; other site 717785001080 conserved gate region; other site 717785001081 putative PBP binding loops; other site 717785001082 ABC-ATPase subunit interface; other site 717785001083 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785001084 SurA N-terminal domain; Region: SurA_N; pfam09312 717785001085 Helix-turn-helix domain; Region: HTH_18; pfam12833 717785001086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785001087 tyramine oxidase; Provisional; Region: tynA; PRK11504 717785001088 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 717785001089 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 717785001090 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 717785001091 Family description; Region: DsbD_2; pfam13386 717785001092 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 717785001093 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 717785001094 dimer interface [polypeptide binding]; other site 717785001095 PYR/PP interface [polypeptide binding]; other site 717785001096 TPP binding site [chemical binding]; other site 717785001097 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785001098 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 717785001099 TPP-binding site [chemical binding]; other site 717785001100 dimer interface [polypeptide binding]; other site 717785001101 FOG: CBS domain [General function prediction only]; Region: COG0517 717785001102 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 717785001103 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 717785001104 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 717785001105 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 717785001106 NAD(P) binding site [chemical binding]; other site 717785001107 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 717785001108 putative dimer interface [polypeptide binding]; other site 717785001109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785001110 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 717785001111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 717785001113 YCII-related domain; Region: YCII; cl00999 717785001114 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 717785001115 putative hydrophobic ligand binding site [chemical binding]; other site 717785001116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785001117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785001118 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 717785001119 putative effector binding pocket; other site 717785001120 putative dimerization interface [polypeptide binding]; other site 717785001121 short chain dehydrogenase; Provisional; Region: PRK12744 717785001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785001123 NAD(P) binding site [chemical binding]; other site 717785001124 active site 717785001125 oxidoreductase; Provisional; Region: PRK06196 717785001126 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 717785001127 putative NAD(P) binding site [chemical binding]; other site 717785001128 active site 717785001129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001131 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 717785001132 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785001133 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 717785001134 putative active site [active] 717785001135 catalytic triad [active] 717785001136 putative dimer interface [polypeptide binding]; other site 717785001137 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 717785001138 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785001139 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785001140 active site 717785001141 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785001142 non-prolyl cis peptide bond; other site 717785001143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785001144 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785001145 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785001146 Walker A/P-loop; other site 717785001147 ATP binding site [chemical binding]; other site 717785001148 Q-loop/lid; other site 717785001149 ABC transporter signature motif; other site 717785001150 Walker B; other site 717785001151 D-loop; other site 717785001152 H-loop/switch region; other site 717785001153 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001155 putative PBP binding loops; other site 717785001156 ABC-ATPase subunit interface; other site 717785001157 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785001158 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785001159 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785001160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785001161 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 717785001162 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 717785001163 dimerization interface [polypeptide binding]; other site 717785001164 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 717785001165 ATP binding site [chemical binding]; other site 717785001166 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 717785001167 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 717785001168 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 717785001169 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 717785001170 Acylphosphatase; Region: Acylphosphatase; pfam00708 717785001171 HypF finger; Region: zf-HYPF; pfam07503 717785001172 HypF finger; Region: zf-HYPF; pfam07503 717785001173 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 717785001174 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785001175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001176 active site 717785001177 phosphorylation site [posttranslational modification] 717785001178 intermolecular recognition site; other site 717785001179 dimerization interface [polypeptide binding]; other site 717785001180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785001181 Walker A motif; other site 717785001182 ATP binding site [chemical binding]; other site 717785001183 Walker B motif; other site 717785001184 arginine finger; other site 717785001185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785001186 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785001187 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 717785001188 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 717785001189 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 717785001190 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 717785001191 Rubredoxin; Region: Rubredoxin; pfam00301 717785001192 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 717785001193 iron binding site [ion binding]; other site 717785001194 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 717785001195 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 717785001196 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 717785001197 HupF/HypC family; Region: HupF_HypC; cl00394 717785001198 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 717785001199 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 717785001200 putative substrate-binding site; other site 717785001201 nickel binding site [ion binding]; other site 717785001202 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 717785001203 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 717785001204 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 717785001205 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 717785001206 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 717785001207 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 717785001208 coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295 717785001209 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 717785001210 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 717785001211 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 717785001212 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 717785001213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785001214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785001215 putative active site [active] 717785001216 heme pocket [chemical binding]; other site 717785001217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785001218 dimer interface [polypeptide binding]; other site 717785001219 phosphorylation site [posttranslational modification] 717785001220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001221 ATP binding site [chemical binding]; other site 717785001222 Mg2+ binding site [ion binding]; other site 717785001223 G-X-G motif; other site 717785001224 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 717785001225 active site 717785001226 DNA binding site [nucleotide binding] 717785001227 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785001228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785001229 active site 717785001230 metal binding site [ion binding]; metal-binding site 717785001231 Cytochrome c; Region: Cytochrom_C; cl11414 717785001232 RNA polymerase sigma factor; Provisional; Region: PRK11924 717785001233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785001235 DNA binding residues [nucleotide binding] 717785001236 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 717785001237 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 717785001238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785001239 DNA-binding site [nucleotide binding]; DNA binding site 717785001240 FCD domain; Region: FCD; pfam07729 717785001241 L-lactate permease; Region: Lactate_perm; cl00701 717785001242 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 717785001243 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785001244 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785001245 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785001246 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785001247 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785001248 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785001249 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 717785001250 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 717785001251 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 717785001252 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 717785001253 tetramer interface [polypeptide binding]; other site 717785001254 catalytic Zn binding site [ion binding]; other site 717785001255 NADP binding site [chemical binding]; other site 717785001256 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 717785001257 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 717785001258 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 717785001259 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 717785001260 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 717785001261 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 717785001262 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 717785001263 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 717785001264 GAF domain; Region: GAF; pfam01590 717785001265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785001266 Walker A motif; other site 717785001267 ATP binding site [chemical binding]; other site 717785001268 Walker B motif; other site 717785001269 arginine finger; other site 717785001270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785001271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785001272 Histidine kinase; Region: HisKA_3; pfam07730 717785001273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001274 ATP binding site [chemical binding]; other site 717785001275 Mg2+ binding site [ion binding]; other site 717785001276 G-X-G motif; other site 717785001277 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001279 active site 717785001280 phosphorylation site [posttranslational modification] 717785001281 intermolecular recognition site; other site 717785001282 dimerization interface [polypeptide binding]; other site 717785001283 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 717785001284 DNA binding residues [nucleotide binding] 717785001285 dimerization interface [polypeptide binding]; other site 717785001286 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 717785001287 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 717785001288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001290 active site 717785001291 phosphorylation site [posttranslational modification] 717785001292 intermolecular recognition site; other site 717785001293 dimerization interface [polypeptide binding]; other site 717785001294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785001295 DNA binding residues [nucleotide binding] 717785001296 dimerization interface [polypeptide binding]; other site 717785001297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 717785001298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 717785001299 Histidine kinase; Region: HisKA_3; pfam07730 717785001300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001301 ATP binding site [chemical binding]; other site 717785001302 Mg2+ binding site [ion binding]; other site 717785001303 G-X-G motif; other site 717785001304 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785001305 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 717785001306 Trp docking motif [polypeptide binding]; other site 717785001307 dimer interface [polypeptide binding]; other site 717785001308 active site 717785001309 small subunit binding site [polypeptide binding]; other site 717785001310 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 717785001311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785001312 substrate binding pocket [chemical binding]; other site 717785001313 membrane-bound complex binding site; other site 717785001314 hinge residues; other site 717785001315 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 717785001316 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 717785001317 MoxR-like ATPases [General function prediction only]; Region: COG0714 717785001318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785001319 Walker A motif; other site 717785001320 ATP binding site [chemical binding]; other site 717785001321 Walker B motif; other site 717785001322 arginine finger; other site 717785001323 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785001324 metal ion-dependent adhesion site (MIDAS); other site 717785001325 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785001326 metal ion-dependent adhesion site (MIDAS); other site 717785001327 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785001328 putative hydrophobic ligand binding site [chemical binding]; other site 717785001329 protein interface [polypeptide binding]; other site 717785001330 gate; other site 717785001331 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 717785001332 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001333 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001334 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001335 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001338 active site 717785001339 phosphorylation site [posttranslational modification] 717785001340 intermolecular recognition site; other site 717785001341 dimerization interface [polypeptide binding]; other site 717785001342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785001343 DNA binding residues [nucleotide binding] 717785001344 dimerization interface [polypeptide binding]; other site 717785001345 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 717785001346 EF-hand domain pair; Region: EF_hand_5; pfam13499 717785001347 Ca2+ binding site [ion binding]; other site 717785001348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785001349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001350 active site 717785001351 phosphorylation site [posttranslational modification] 717785001352 intermolecular recognition site; other site 717785001353 dimerization interface [polypeptide binding]; other site 717785001354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785001355 DNA binding site [nucleotide binding] 717785001356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785001357 HAMP domain; Region: HAMP; pfam00672 717785001358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785001359 dimer interface [polypeptide binding]; other site 717785001360 phosphorylation site [posttranslational modification] 717785001361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001362 ATP binding site [chemical binding]; other site 717785001363 Mg2+ binding site [ion binding]; other site 717785001364 G-X-G motif; other site 717785001365 Thermostable hemolysin; Region: T_hemolysin; pfam12261 717785001366 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785001367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785001368 acyl-activating enzyme (AAE) consensus motif; other site 717785001369 AMP binding site [chemical binding]; other site 717785001370 active site 717785001371 CoA binding site [chemical binding]; other site 717785001372 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 717785001373 heme binding pocket [chemical binding]; other site 717785001374 heme ligand [chemical binding]; other site 717785001375 short chain dehydrogenase; Provisional; Region: PRK09072 717785001376 classical (c) SDRs; Region: SDR_c; cd05233 717785001377 NAD(P) binding site [chemical binding]; other site 717785001378 active site 717785001379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785001380 TPR motif; other site 717785001381 binding surface 717785001382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785001383 S-adenosylmethionine binding site [chemical binding]; other site 717785001384 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785001385 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785001386 catalytic residues [active] 717785001387 catalytic nucleophile [active] 717785001388 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785001389 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785001390 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785001391 Synaptic Site I dimer interface [polypeptide binding]; other site 717785001392 DNA binding site [nucleotide binding] 717785001393 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 717785001394 DNA-binding interface [nucleotide binding]; DNA binding site 717785001395 Methyltransferase domain; Region: Methyltransf_26; pfam13659 717785001396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785001397 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785001398 active site 717785001399 DNA binding site [nucleotide binding] 717785001400 Int/Topo IB signature motif; other site 717785001401 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 717785001402 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 717785001403 putative NAD(P) binding site [chemical binding]; other site 717785001404 active site 717785001405 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 717785001406 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785001407 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 717785001408 putative dimer interface [polypeptide binding]; other site 717785001409 ABC transporter ATPase component; Reviewed; Region: PRK11147 717785001410 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785001411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785001412 Protein of unknown function (DUF466); Region: DUF466; pfam04328 717785001413 carbon starvation protein A; Provisional; Region: PRK15015 717785001414 Carbon starvation protein CstA; Region: CstA; pfam02554 717785001415 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 717785001416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 717785001417 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 717785001418 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 717785001419 hinge; other site 717785001420 active site 717785001421 cytidylate kinase; Provisional; Region: cmk; PRK00023 717785001422 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 717785001423 CMP-binding site; other site 717785001424 The sites determining sugar specificity; other site 717785001425 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 717785001426 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 717785001427 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 717785001428 dimer interface [polypeptide binding]; other site 717785001429 TPP-binding site [chemical binding]; other site 717785001430 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 717785001431 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 717785001432 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785001433 E3 interaction surface; other site 717785001434 lipoyl attachment site [posttranslational modification]; other site 717785001435 e3 binding domain; Region: E3_binding; pfam02817 717785001436 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 717785001437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785001438 E3 interaction surface; other site 717785001439 lipoyl attachment site [posttranslational modification]; other site 717785001440 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 717785001441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785001442 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785001443 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 717785001444 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 717785001445 RNA binding site [nucleotide binding]; other site 717785001446 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 717785001447 RNA binding site [nucleotide binding]; other site 717785001448 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 717785001449 RNA binding site [nucleotide binding]; other site 717785001450 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 717785001451 RNA binding site [nucleotide binding]; other site 717785001452 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 717785001453 RNA binding site [nucleotide binding]; other site 717785001454 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 717785001455 RNA binding site [nucleotide binding]; other site 717785001456 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 717785001457 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 717785001458 tandem repeat interface [polypeptide binding]; other site 717785001459 oligomer interface [polypeptide binding]; other site 717785001460 active site residues [active] 717785001461 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 717785001462 IHF dimer interface [polypeptide binding]; other site 717785001463 IHF - DNA interface [nucleotide binding]; other site 717785001464 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 717785001465 active site 717785001466 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 717785001467 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 717785001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785001469 catalytic residue [active] 717785001470 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 717785001471 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 717785001472 substrate binding site [chemical binding]; other site 717785001473 active site 717785001474 catalytic residues [active] 717785001475 heterodimer interface [polypeptide binding]; other site 717785001476 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 717785001477 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 717785001478 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 717785001479 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 717785001480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785001481 NAD(P) binding site [chemical binding]; other site 717785001482 catalytic residues [active] 717785001483 Protein of unknown function (DUF779); Region: DUF779; cl01432 717785001484 Protein of unknown function (DUF779); Region: DUF779; pfam05610 717785001485 Isochorismatase family; Region: Isochorismatase; pfam00857 717785001486 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 717785001487 catalytic triad [active] 717785001488 conserved cis-peptide bond; other site 717785001489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 717785001490 catalytic residues [active] 717785001491 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 717785001492 Family description; Region: UvrD_C_2; pfam13538 717785001493 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 717785001494 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 717785001495 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 717785001496 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 717785001497 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 717785001498 Substrate binding site; other site 717785001499 metal-binding site 717785001500 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 717785001501 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 717785001502 Phosphotransferase enzyme family; Region: APH; pfam01636 717785001503 PAS fold; Region: PAS_7; pfam12860 717785001504 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785001505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785001506 dimer interface [polypeptide binding]; other site 717785001507 phosphorylation site [posttranslational modification] 717785001508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001509 ATP binding site [chemical binding]; other site 717785001510 Mg2+ binding site [ion binding]; other site 717785001511 G-X-G motif; other site 717785001512 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 717785001513 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 717785001514 homotetramer interface [polypeptide binding]; other site 717785001515 ligand binding site [chemical binding]; other site 717785001516 catalytic site [active] 717785001517 NAD binding site [chemical binding]; other site 717785001518 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001519 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 717785001520 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785001521 metal ion-dependent adhesion site (MIDAS); other site 717785001522 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785001523 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 717785001524 dimerization domain swap beta strand [polypeptide binding]; other site 717785001525 regulatory protein interface [polypeptide binding]; other site 717785001526 active site 717785001527 regulatory phosphorylation site [posttranslational modification]; other site 717785001528 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 717785001529 active pocket/dimerization site; other site 717785001530 active site 717785001531 phosphorylation site [posttranslational modification] 717785001532 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 717785001533 Hpr binding site; other site 717785001534 active site 717785001535 homohexamer subunit interaction site [polypeptide binding]; other site 717785001536 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 717785001537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785001538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785001539 dimer interface [polypeptide binding]; other site 717785001540 phosphorylation site [posttranslational modification] 717785001541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001542 ATP binding site [chemical binding]; other site 717785001543 Mg2+ binding site [ion binding]; other site 717785001544 G-X-G motif; other site 717785001545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001547 active site 717785001548 phosphorylation site [posttranslational modification] 717785001549 intermolecular recognition site; other site 717785001550 dimerization interface [polypeptide binding]; other site 717785001551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785001552 DNA binding site [nucleotide binding] 717785001553 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 717785001554 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 717785001555 active site 717785001556 substrate-binding site [chemical binding]; other site 717785001557 metal-binding site [ion binding] 717785001558 ATP binding site [chemical binding]; other site 717785001559 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 717785001560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785001561 active site 717785001562 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 717785001563 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 717785001564 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 717785001565 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785001566 catalytic residues [active] 717785001567 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 717785001568 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 717785001569 SnoaL-like domain; Region: SnoaL_3; pfam13474 717785001570 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 717785001571 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 717785001572 ATP-grasp domain; Region: ATP-grasp; pfam02222 717785001573 AIR carboxylase; Region: AIRC; pfam00731 717785001574 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785001575 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 717785001576 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 717785001577 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 717785001578 metal binding site [ion binding]; metal-binding site 717785001579 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 717785001580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001581 active site 717785001582 phosphorylation site [posttranslational modification] 717785001583 intermolecular recognition site; other site 717785001584 dimerization interface [polypeptide binding]; other site 717785001585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785001586 DNA binding site [nucleotide binding] 717785001587 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 717785001588 PhoU domain; Region: PhoU; pfam01895 717785001589 PhoU domain; Region: PhoU; pfam01895 717785001590 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 717785001591 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 717785001592 Walker A/P-loop; other site 717785001593 ATP binding site [chemical binding]; other site 717785001594 Q-loop/lid; other site 717785001595 ABC transporter signature motif; other site 717785001596 Walker B; other site 717785001597 D-loop; other site 717785001598 H-loop/switch region; other site 717785001599 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 717785001600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001601 dimer interface [polypeptide binding]; other site 717785001602 conserved gate region; other site 717785001603 putative PBP binding loops; other site 717785001604 ABC-ATPase subunit interface; other site 717785001605 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 717785001606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001607 dimer interface [polypeptide binding]; other site 717785001608 conserved gate region; other site 717785001609 putative PBP binding loops; other site 717785001610 ABC-ATPase subunit interface; other site 717785001611 PBP superfamily domain; Region: PBP_like_2; cl17296 717785001612 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785001613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785001614 dimer interface [polypeptide binding]; other site 717785001615 phosphorylation site [posttranslational modification] 717785001616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001617 ATP binding site [chemical binding]; other site 717785001618 Mg2+ binding site [ion binding]; other site 717785001619 G-X-G motif; other site 717785001620 Transcriptional regulator; Region: Rrf2; cl17282 717785001621 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785001622 Imelysin; Region: Peptidase_M75; cl09159 717785001623 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 717785001624 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 717785001625 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 717785001626 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 717785001627 Imelysin; Region: Peptidase_M75; cl09159 717785001628 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 717785001629 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 717785001630 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 717785001631 Ligand binding site; other site 717785001632 metal-binding site 717785001633 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 717785001634 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785001635 XdhC Rossmann domain; Region: XdhC_C; pfam13478 717785001636 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 717785001637 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785001638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785001639 FeS/SAM binding site; other site 717785001640 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717785001641 Cation efflux family; Region: Cation_efflux; pfam01545 717785001642 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 717785001643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001645 WHG domain; Region: WHG; pfam13305 717785001646 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001647 TadE-like protein; Region: TadE; pfam07811 717785001648 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001649 TadE-like protein; Region: TadE; pfam07811 717785001650 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 717785001651 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 717785001652 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 717785001653 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 717785001654 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 717785001655 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 717785001656 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 717785001657 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 717785001658 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 717785001659 Type IV pili component [Cell motility and secretion]; Region: COG5461 717785001660 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 717785001661 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 717785001662 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 717785001663 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 717785001664 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 717785001665 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 717785001666 ATP binding site [chemical binding]; other site 717785001667 Walker A motif; other site 717785001668 hexamer interface [polypeptide binding]; other site 717785001669 Walker B motif; other site 717785001670 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 717785001671 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717785001672 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 717785001673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717785001674 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 717785001675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 717785001676 binding surface 717785001677 TPR motif; other site 717785001678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785001679 TPR motif; other site 717785001680 binding surface 717785001681 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 717785001682 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 717785001683 interface (dimer of trimers) [polypeptide binding]; other site 717785001684 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 717785001685 Substrate-binding/catalytic site; other site 717785001686 Zn-binding sites [ion binding]; other site 717785001687 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 717785001688 NlpC/P60 family; Region: NLPC_P60; pfam00877 717785001689 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785001690 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 717785001691 putative C-terminal domain interface [polypeptide binding]; other site 717785001692 putative GSH binding site (G-site) [chemical binding]; other site 717785001693 putative dimer interface [polypeptide binding]; other site 717785001694 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 717785001695 dimer interface [polypeptide binding]; other site 717785001696 N-terminal domain interface [polypeptide binding]; other site 717785001697 putative substrate binding pocket (H-site) [chemical binding]; other site 717785001698 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 717785001699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 717785001700 Walker A/P-loop; other site 717785001701 ATP binding site [chemical binding]; other site 717785001702 Q-loop/lid; other site 717785001703 ABC transporter signature motif; other site 717785001704 Walker B; other site 717785001705 D-loop; other site 717785001706 H-loop/switch region; other site 717785001707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 717785001708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 717785001709 Walker A/P-loop; other site 717785001710 ATP binding site [chemical binding]; other site 717785001711 Q-loop/lid; other site 717785001712 ABC transporter signature motif; other site 717785001713 Walker B; other site 717785001714 D-loop; other site 717785001715 H-loop/switch region; other site 717785001716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 717785001717 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 717785001718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001719 dimer interface [polypeptide binding]; other site 717785001720 conserved gate region; other site 717785001721 putative PBP binding loops; other site 717785001722 ABC-ATPase subunit interface; other site 717785001723 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 717785001724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001725 dimer interface [polypeptide binding]; other site 717785001726 conserved gate region; other site 717785001727 putative PBP binding loops; other site 717785001728 ABC-ATPase subunit interface; other site 717785001729 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785001730 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785001731 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785001732 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785001733 Cytochrome c2 [Energy production and conversion]; Region: COG3474 717785001734 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 717785001735 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 717785001736 Ligand binding site; other site 717785001737 oligomer interface; other site 717785001738 prephenate dehydratase; Provisional; Region: PRK11899 717785001739 Prephenate dehydratase; Region: PDT; pfam00800 717785001740 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 717785001741 putative L-Phe binding site [chemical binding]; other site 717785001742 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 717785001743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785001744 Walker A motif; other site 717785001745 ATP binding site [chemical binding]; other site 717785001746 Walker B motif; other site 717785001747 arginine finger; other site 717785001748 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 717785001749 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 717785001750 hypothetical protein; Validated; Region: PRK00153 717785001751 recombination protein RecR; Reviewed; Region: recR; PRK00076 717785001752 RecR protein; Region: RecR; pfam02132 717785001753 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 717785001754 putative active site [active] 717785001755 putative metal-binding site [ion binding]; other site 717785001756 tetramer interface [polypeptide binding]; other site 717785001757 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 717785001758 putative efflux protein, MATE family; Region: matE; TIGR00797 717785001759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785001760 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717785001761 NAD(P) binding site [chemical binding]; other site 717785001762 active site 717785001763 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 717785001764 active site 717785001765 catalytic residues [active] 717785001766 metal binding site [ion binding]; metal-binding site 717785001767 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 717785001768 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 717785001769 putative active site [active] 717785001770 substrate binding site [chemical binding]; other site 717785001771 putative cosubstrate binding site; other site 717785001772 catalytic site [active] 717785001773 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 717785001774 substrate binding site [chemical binding]; other site 717785001775 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 717785001776 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 717785001777 dimerization interface 3.5A [polypeptide binding]; other site 717785001778 active site 717785001779 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 717785001780 GTP cyclohydrolase I; Provisional; Region: PLN03044 717785001781 active site 717785001782 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785001783 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785001784 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785001785 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785001786 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 717785001787 MgtE intracellular N domain; Region: MgtE_N; pfam03448 717785001788 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 717785001789 Divalent cation transporter; Region: MgtE; pfam01769 717785001790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001792 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 717785001793 Methyltransferase domain; Region: Methyltransf_24; pfam13578 717785001794 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785001795 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 717785001796 NAD(P) binding site [chemical binding]; other site 717785001797 catalytic residues [active] 717785001798 short chain dehydrogenase; Provisional; Region: PRK12937 717785001799 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 717785001800 NADP binding site [chemical binding]; other site 717785001801 homodimer interface [polypeptide binding]; other site 717785001802 active site 717785001803 substrate binding site [chemical binding]; other site 717785001804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785001805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785001806 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 717785001807 putative effector binding pocket; other site 717785001808 putative dimerization interface [polypeptide binding]; other site 717785001809 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 717785001810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785001811 active site 717785001812 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 717785001813 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 717785001814 hinge; other site 717785001815 active site 717785001816 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 717785001817 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 717785001818 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 717785001819 NAD binding site [chemical binding]; other site 717785001820 dimerization interface [polypeptide binding]; other site 717785001821 product binding site; other site 717785001822 substrate binding site [chemical binding]; other site 717785001823 zinc binding site [ion binding]; other site 717785001824 catalytic residues [active] 717785001825 hypothetical protein; Provisional; Region: PRK02853 717785001826 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 717785001827 cyclase homology domain; Region: CHD; cd07302 717785001828 nucleotidyl binding site; other site 717785001829 metal binding site [ion binding]; metal-binding site 717785001830 dimer interface [polypeptide binding]; other site 717785001831 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785001832 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785001833 ligand binding site [chemical binding]; other site 717785001834 flexible hinge region; other site 717785001835 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785001836 putative switch regulator; other site 717785001837 non-specific DNA interactions [nucleotide binding]; other site 717785001838 DNA binding site [nucleotide binding] 717785001839 sequence specific DNA binding site [nucleotide binding]; other site 717785001840 putative cAMP binding site [chemical binding]; other site 717785001841 Maf-like protein; Region: Maf; pfam02545 717785001842 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 717785001843 active site 717785001844 dimer interface [polypeptide binding]; other site 717785001845 Domain of unknown function (DUF329); Region: DUF329; pfam03884 717785001846 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 717785001847 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 717785001848 Moco binding site; other site 717785001849 metal coordination site [ion binding]; other site 717785001850 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785001851 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 717785001852 Cupin; Region: Cupin_1; smart00835 717785001853 Cupin; Region: Cupin_1; smart00835 717785001854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785001855 binding surface 717785001856 TPR repeat; Region: TPR_11; pfam13414 717785001857 TPR motif; other site 717785001858 TPR repeat; Region: TPR_11; pfam13414 717785001859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785001860 ligand binding site [chemical binding]; other site 717785001861 flexible hinge region; other site 717785001862 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785001863 putative switch regulator; other site 717785001864 non-specific DNA interactions [nucleotide binding]; other site 717785001865 DNA binding site [nucleotide binding] 717785001866 sequence specific DNA binding site [nucleotide binding]; other site 717785001867 putative cAMP binding site [chemical binding]; other site 717785001868 rhodanese superfamily protein; Provisional; Region: PRK05320 717785001869 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 717785001870 active site residue [active] 717785001871 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717785001872 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785001873 Walker A/P-loop; other site 717785001874 ATP binding site [chemical binding]; other site 717785001875 Q-loop/lid; other site 717785001876 ABC transporter signature motif; other site 717785001877 Walker B; other site 717785001878 D-loop; other site 717785001879 H-loop/switch region; other site 717785001880 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 717785001881 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717785001882 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 717785001883 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 717785001884 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 717785001885 FMN binding site [chemical binding]; other site 717785001886 dimer interface [polypeptide binding]; other site 717785001887 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 717785001888 active site 717785001889 SAM binding site [chemical binding]; other site 717785001890 homodimer interface [polypeptide binding]; other site 717785001891 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 717785001892 cobyric acid synthase; Provisional; Region: PRK00784 717785001893 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785001894 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 717785001895 catalytic triad [active] 717785001896 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 717785001897 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 717785001898 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 717785001899 homodimer interface [polypeptide binding]; other site 717785001900 Walker A motif; other site 717785001901 ATP binding site [chemical binding]; other site 717785001902 hydroxycobalamin binding site [chemical binding]; other site 717785001903 Walker B motif; other site 717785001904 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 717785001905 homotrimer interface [polypeptide binding]; other site 717785001906 Walker A motif; other site 717785001907 GTP binding site [chemical binding]; other site 717785001908 Walker B motif; other site 717785001909 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 717785001910 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 717785001911 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 717785001912 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 717785001913 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 717785001914 precorrin-3B synthase; Region: CobG; TIGR02435 717785001915 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785001916 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 717785001917 Precorrin-8X methylmutase; Region: CbiC; pfam02570 717785001918 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 717785001919 active site 717785001920 SAM binding site [chemical binding]; other site 717785001921 homodimer interface [polypeptide binding]; other site 717785001922 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 717785001923 active site 717785001924 SAM binding site [chemical binding]; other site 717785001925 homodimer interface [polypeptide binding]; other site 717785001926 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 717785001927 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 717785001928 active site 717785001929 putative homodimer interface [polypeptide binding]; other site 717785001930 SAM binding site [chemical binding]; other site 717785001931 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 717785001932 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 717785001933 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 717785001934 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 717785001935 active site 717785001936 SAM binding site [chemical binding]; other site 717785001937 homodimer interface [polypeptide binding]; other site 717785001938 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 717785001939 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785001940 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 717785001941 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785001942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785001944 DNA binding residues [nucleotide binding] 717785001945 two-component response regulator; Provisional; Region: PRK09191 717785001946 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717785001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001948 active site 717785001949 phosphorylation site [posttranslational modification] 717785001950 intermolecular recognition site; other site 717785001951 dimerization interface [polypeptide binding]; other site 717785001952 PRC-barrel domain; Region: PRC; pfam05239 717785001953 CsbD-like; Region: CsbD; cl17424 717785001954 CHASE3 domain; Region: CHASE3; pfam05227 717785001955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785001956 Histidine kinase; Region: HisKA_2; pfam07568 717785001957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001958 ATP binding site [chemical binding]; other site 717785001959 Mg2+ binding site [ion binding]; other site 717785001960 G-X-G motif; other site 717785001961 response regulator; Provisional; Region: PRK13435 717785001962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785001963 active site 717785001964 phosphorylation site [posttranslational modification] 717785001965 intermolecular recognition site; other site 717785001966 dimerization interface [polypeptide binding]; other site 717785001967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785001968 PAS fold; Region: PAS_3; pfam08447 717785001969 putative active site [active] 717785001970 heme pocket [chemical binding]; other site 717785001971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785001972 HWE histidine kinase; Region: HWE_HK; pfam07536 717785001973 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 717785001974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785001975 ATP binding site [chemical binding]; other site 717785001976 ABC transporter; Region: ABC_tran; pfam00005 717785001977 Q-loop/lid; other site 717785001978 ABC transporter signature motif; other site 717785001979 Walker B; other site 717785001980 D-loop; other site 717785001981 H-loop/switch region; other site 717785001982 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785001983 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717785001984 FtsX-like permease family; Region: FtsX; pfam02687 717785001985 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 717785001986 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 717785001987 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 717785001988 Serine hydrolase; Region: Ser_hydrolase; pfam06821 717785001989 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785001990 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785001991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785001992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785001993 non-specific DNA binding site [nucleotide binding]; other site 717785001994 salt bridge; other site 717785001995 sequence-specific DNA binding site [nucleotide binding]; other site 717785001996 Cupin domain; Region: Cupin_2; pfam07883 717785001997 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 717785001998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785001999 dimer interface [polypeptide binding]; other site 717785002000 conserved gate region; other site 717785002001 putative PBP binding loops; other site 717785002002 ABC-ATPase subunit interface; other site 717785002003 sulfate transport protein; Provisional; Region: cysT; CHL00187 717785002004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785002005 dimer interface [polypeptide binding]; other site 717785002006 conserved gate region; other site 717785002007 putative PBP binding loops; other site 717785002008 ABC-ATPase subunit interface; other site 717785002009 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 717785002010 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 717785002011 Walker A/P-loop; other site 717785002012 ATP binding site [chemical binding]; other site 717785002013 Q-loop/lid; other site 717785002014 ABC transporter signature motif; other site 717785002015 Walker B; other site 717785002016 D-loop; other site 717785002017 H-loop/switch region; other site 717785002018 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785002019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785002020 dimerization interface [polypeptide binding]; other site 717785002021 putative Zn2+ binding site [ion binding]; other site 717785002022 putative DNA binding site [nucleotide binding]; other site 717785002023 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 717785002024 substrate binding site [chemical binding]; other site 717785002025 dimerization interface [polypeptide binding]; other site 717785002026 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 717785002027 lipoyl synthase; Provisional; Region: PRK05481 717785002028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785002029 FeS/SAM binding site; other site 717785002030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 717785002031 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785002032 Cupin domain; Region: Cupin_2; cl17218 717785002033 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 717785002034 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 717785002035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785002036 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 717785002037 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 717785002038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785002039 putative substrate translocation pore; other site 717785002040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785002041 putative acyl-acceptor binding pocket; other site 717785002042 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785002043 acyl-activating enzyme (AAE) consensus motif; other site 717785002044 AMP binding site [chemical binding]; other site 717785002045 active site 717785002046 CoA binding site [chemical binding]; other site 717785002047 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 717785002048 thiS-thiF/thiG interaction site; other site 717785002049 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 717785002050 ThiS interaction site; other site 717785002051 putative active site [active] 717785002052 tetramer interface [polypeptide binding]; other site 717785002053 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 717785002054 thiamine phosphate binding site [chemical binding]; other site 717785002055 active site 717785002056 pyrophosphate binding site [ion binding]; other site 717785002057 CHAD domain; Region: CHAD; pfam05235 717785002058 ferrochelatase; Reviewed; Region: hemH; PRK00035 717785002059 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 717785002060 C-terminal domain interface [polypeptide binding]; other site 717785002061 active site 717785002062 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 717785002063 active site 717785002064 N-terminal domain interface [polypeptide binding]; other site 717785002065 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 717785002066 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 717785002067 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 717785002068 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 717785002069 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 717785002070 putative active site [active] 717785002071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 717785002072 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 717785002073 active site 717785002074 tetramer interface; other site 717785002075 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 717785002076 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 717785002077 NAD binding site [chemical binding]; other site 717785002078 homodimer interface [polypeptide binding]; other site 717785002079 active site 717785002080 substrate binding site [chemical binding]; other site 717785002081 Transglycosylase SLT domain; Region: SLT_2; pfam13406 717785002082 murein hydrolase B; Provisional; Region: PRK10760; cl17906 717785002083 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785002084 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717785002085 active site 717785002086 catalytic triad [active] 717785002087 oxyanion hole [active] 717785002088 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 717785002089 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 717785002090 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 717785002091 active site 717785002092 dimer interface [polypeptide binding]; other site 717785002093 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 717785002094 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 717785002095 active site 717785002096 FMN binding site [chemical binding]; other site 717785002097 substrate binding site [chemical binding]; other site 717785002098 3Fe-4S cluster binding site [ion binding]; other site 717785002099 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 717785002100 domain interface; other site 717785002101 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785002102 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 717785002103 putative dimer interface [polypeptide binding]; other site 717785002104 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 717785002105 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785002106 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 717785002107 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 717785002108 active site 717785002109 N-formylglutamate amidohydrolase; Region: FGase; cl01522 717785002110 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002112 active site 717785002113 phosphorylation site [posttranslational modification] 717785002114 intermolecular recognition site; other site 717785002115 dimerization interface [polypeptide binding]; other site 717785002116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785002117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785002118 S-adenosylmethionine binding site [chemical binding]; other site 717785002119 Cupin domain; Region: Cupin_2; pfam07883 717785002120 TPR repeat; Region: TPR_11; pfam13414 717785002121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785002122 binding surface 717785002123 TPR motif; other site 717785002124 TPR repeat; Region: TPR_11; pfam13414 717785002125 pyruvate kinase; Provisional; Region: PRK06247 717785002126 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 717785002127 domain interfaces; other site 717785002128 active site 717785002129 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 717785002130 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 717785002131 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 717785002132 MOFRL family; Region: MOFRL; pfam05161 717785002133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 717785002134 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 717785002135 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 717785002136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785002137 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 717785002138 dimerization interface [polypeptide binding]; other site 717785002139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 717785002140 Peptidase M15; Region: Peptidase_M15_3; cl01194 717785002141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785002142 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785002143 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785002144 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785002145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002146 active site 717785002147 phosphorylation site [posttranslational modification] 717785002148 intermolecular recognition site; other site 717785002149 dimerization interface [polypeptide binding]; other site 717785002150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002151 Walker A motif; other site 717785002152 ATP binding site [chemical binding]; other site 717785002153 Walker B motif; other site 717785002154 arginine finger; other site 717785002155 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785002156 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 717785002157 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 717785002158 active site 717785002159 Zn binding site [ion binding]; other site 717785002160 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 717785002161 potassium uptake protein; Region: kup; TIGR00794 717785002162 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 717785002163 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1633824, 3525165; Product type e : enzyme 717785002164 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1633824, 3525165; Product type e : enzyme 717785002165 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 717785002166 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 717785002167 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 717785002168 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785002169 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 717785002170 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 717785002171 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 717785002172 SnoaL-like domain; Region: SnoaL_3; pfam13474 717785002173 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 717785002174 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 717785002175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 717785002176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785002177 substrate binding pocket [chemical binding]; other site 717785002178 membrane-bound complex binding site; other site 717785002179 hinge residues; other site 717785002180 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 717785002181 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717785002182 DXD motif; other site 717785002183 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 717785002184 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 717785002185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785002186 S-adenosylmethionine binding site [chemical binding]; other site 717785002187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 717785002188 putative acyl-acceptor binding pocket; other site 717785002189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785002190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785002191 metal binding site [ion binding]; metal-binding site 717785002192 active site 717785002193 I-site; other site 717785002194 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 717785002195 Amidinotransferase; Region: Amidinotransf; pfam02274 717785002196 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 717785002197 Creatinine amidohydrolase; Region: Creatininase; pfam02633 717785002198 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785002199 classical (c) SDRs; Region: SDR_c; cd05233 717785002200 NAD(P) binding site [chemical binding]; other site 717785002201 active site 717785002202 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785002203 classical (c) SDRs; Region: SDR_c; cd05233 717785002204 NAD(P) binding site [chemical binding]; other site 717785002205 active site 717785002206 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785002207 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785002208 Walker A/P-loop; other site 717785002209 ATP binding site [chemical binding]; other site 717785002210 Q-loop/lid; other site 717785002211 ABC transporter signature motif; other site 717785002212 Walker B; other site 717785002213 D-loop; other site 717785002214 H-loop/switch region; other site 717785002215 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785002217 dimer interface [polypeptide binding]; other site 717785002218 conserved gate region; other site 717785002219 putative PBP binding loops; other site 717785002220 ABC-ATPase subunit interface; other site 717785002221 NMT1/THI5 like; Region: NMT1; pfam09084 717785002222 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785002223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785002224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785002225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785002226 dimerization interface [polypeptide binding]; other site 717785002227 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785002228 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 717785002229 Trp docking motif [polypeptide binding]; other site 717785002230 dimer interface [polypeptide binding]; other site 717785002231 active site 717785002232 small subunit binding site [polypeptide binding]; other site 717785002233 Chorismate mutase type II; Region: CM_2; cl00693 717785002234 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 717785002235 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 717785002236 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 717785002237 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 717785002238 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 717785002239 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 717785002240 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 717785002241 TAP-like protein; Region: Abhydrolase_4; pfam08386 717785002242 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785002243 Sel1-like repeats; Region: SEL1; smart00671 717785002244 Sel1-like repeats; Region: SEL1; smart00671 717785002245 Sel1-like repeats; Region: SEL1; smart00671 717785002246 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785002247 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 717785002248 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 717785002249 putative active site [active] 717785002250 putative metal binding site [ion binding]; other site 717785002251 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 717785002252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785002253 ATP binding site [chemical binding]; other site 717785002254 putative Mg++ binding site [ion binding]; other site 717785002255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002256 nucleotide binding region [chemical binding]; other site 717785002257 ATP-binding site [chemical binding]; other site 717785002258 DEAD/H associated; Region: DEAD_assoc; pfam08494 717785002259 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 717785002260 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 717785002261 quinone interaction residues [chemical binding]; other site 717785002262 active site 717785002263 catalytic residues [active] 717785002264 FMN binding site [chemical binding]; other site 717785002265 substrate binding site [chemical binding]; other site 717785002266 Protein of unknown function (DUF952); Region: DUF952; pfam06108 717785002267 Protein of unknown function DUF262; Region: DUF262; pfam03235 717785002268 Uncharacterized conserved protein [Function unknown]; Region: COG1479 717785002269 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 717785002270 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 717785002271 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785002272 active site 717785002273 nucleotide binding site [chemical binding]; other site 717785002274 HIGH motif; other site 717785002275 KMSKS motif; other site 717785002276 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785002277 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 717785002278 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 717785002279 methionine sulfoxide reductase A; Provisional; Region: PRK00058 717785002280 integrase; Provisional; Region: PRK09692 717785002281 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785002282 active site 717785002283 Int/Topo IB signature motif; other site 717785002284 Helix-turn-helix domain; Region: HTH_17; cl17695 717785002285 Helix-turn-helix domain; Region: HTH_36; pfam13730 717785002286 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 717785002287 AAA domain; Region: AAA_33; pfam13671 717785002288 AAA domain; Region: AAA_17; pfam13207 717785002289 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 717785002290 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 717785002291 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 717785002292 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 717785002293 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785002294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785002295 ligand binding site [chemical binding]; other site 717785002296 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 717785002297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785002298 Predicted flavoprotein [General function prediction only]; Region: COG0431 717785002299 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785002300 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 717785002301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785002302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002303 ATP binding site [chemical binding]; other site 717785002304 Mg2+ binding site [ion binding]; other site 717785002305 G-X-G motif; other site 717785002306 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785002307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002308 active site 717785002309 phosphorylation site [posttranslational modification] 717785002310 intermolecular recognition site; other site 717785002311 dimerization interface [polypeptide binding]; other site 717785002312 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002314 active site 717785002315 phosphorylation site [posttranslational modification] 717785002316 intermolecular recognition site; other site 717785002317 dimerization interface [polypeptide binding]; other site 717785002318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785002319 Histidine kinase; Region: HisKA_2; pfam07568 717785002320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002321 ATP binding site [chemical binding]; other site 717785002322 Mg2+ binding site [ion binding]; other site 717785002323 G-X-G motif; other site 717785002324 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 717785002325 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785002326 active site 717785002327 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 717785002328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 717785002329 nucleotide binding site [chemical binding]; other site 717785002330 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 717785002331 Autotransporter beta-domain; Region: Autotransporter; pfam03797 717785002332 LTXXQ motif family protein; Region: LTXXQ; pfam07813 717785002333 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 717785002334 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 717785002335 ATP binding site [chemical binding]; other site 717785002336 Mg++ binding site [ion binding]; other site 717785002337 motif III; other site 717785002338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002339 nucleotide binding region [chemical binding]; other site 717785002340 ATP-binding site [chemical binding]; other site 717785002341 nitrosocyanin; Region: nitroso_cyanin; TIGR03096 717785002342 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 717785002343 LTXXQ motif family protein; Region: LTXXQ; pfam07813 717785002344 Domain of unknown function DUF302; Region: DUF302; pfam03625 717785002345 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 717785002346 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 717785002347 active site 717785002348 substrate binding site [chemical binding]; other site 717785002349 coenzyme B12 binding site [chemical binding]; other site 717785002350 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 717785002351 B12 binding site [chemical binding]; other site 717785002352 cobalt ligand [ion binding]; other site 717785002353 Protein of unknown function (DUF817); Region: DUF817; pfam05675 717785002354 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 717785002355 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 717785002356 putative ion selectivity filter; other site 717785002357 putative pore gating glutamate residue; other site 717785002358 putative H+/Cl- coupling transport residue; other site 717785002359 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 717785002360 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 717785002361 heterodimer interface [polypeptide binding]; other site 717785002362 substrate interaction site [chemical binding]; other site 717785002363 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 717785002364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 717785002365 Walker A motif; other site 717785002366 ATP binding site [chemical binding]; other site 717785002367 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 717785002368 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785002369 nucleophile elbow; other site 717785002370 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785002371 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785002372 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785002373 K-box region; Region: K-box; pfam01486 717785002374 H-NS histone family; Region: Histone_HNS; pfam00816 717785002375 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 717785002376 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 717785002377 oligomerisation interface [polypeptide binding]; other site 717785002378 mobile loop; other site 717785002379 roof hairpin; other site 717785002380 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 717785002381 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 717785002382 ring oligomerisation interface [polypeptide binding]; other site 717785002383 ATP/Mg binding site [chemical binding]; other site 717785002384 stacking interactions; other site 717785002385 hinge regions; other site 717785002386 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 717785002387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785002388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785002389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785002390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785002391 S-adenosylmethionine binding site [chemical binding]; other site 717785002392 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 717785002393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785002394 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 717785002395 putative active site [active] 717785002396 putative metal binding site [ion binding]; other site 717785002397 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 717785002398 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 717785002399 active site 717785002400 NTP binding site [chemical binding]; other site 717785002401 metal binding triad [ion binding]; metal-binding site 717785002402 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 717785002403 putative active site [active] 717785002404 putative CoA binding site [chemical binding]; other site 717785002405 nudix motif; other site 717785002406 metal binding site [ion binding]; metal-binding site 717785002407 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 717785002408 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 717785002409 FMN binding site [chemical binding]; other site 717785002410 active site 717785002411 substrate binding site [chemical binding]; other site 717785002412 catalytic residue [active] 717785002413 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 717785002414 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 717785002415 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 717785002416 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785002417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785002418 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 717785002419 Walker A/P-loop; other site 717785002420 ATP binding site [chemical binding]; other site 717785002421 Q-loop/lid; other site 717785002422 ABC transporter signature motif; other site 717785002423 Walker B; other site 717785002424 D-loop; other site 717785002425 H-loop/switch region; other site 717785002426 Phospholipid methyltransferase; Region: PEMT; pfam04191 717785002427 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 717785002428 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 717785002429 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 717785002430 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 717785002431 [2Fe-2S] cluster binding site [ion binding]; other site 717785002432 cytochrome b; Provisional; Region: CYTB; MTH00119 717785002433 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 717785002434 Qi binding site; other site 717785002435 intrachain domain interface; other site 717785002436 interchain domain interface [polypeptide binding]; other site 717785002437 heme bH binding site [chemical binding]; other site 717785002438 heme bL binding site [chemical binding]; other site 717785002439 Qo binding site; other site 717785002440 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 717785002441 interchain domain interface [polypeptide binding]; other site 717785002442 intrachain domain interface; other site 717785002443 Qi binding site; other site 717785002444 Qo binding site; other site 717785002445 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 717785002446 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 717785002447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785002448 active site 717785002449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785002450 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 717785002451 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 717785002452 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 717785002453 intersubunit interface [polypeptide binding]; other site 717785002454 active site 717785002455 Zn2+ binding site [ion binding]; other site 717785002456 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 717785002457 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 717785002458 tetramer interface [polypeptide binding]; other site 717785002459 heme binding pocket [chemical binding]; other site 717785002460 NADPH binding site [chemical binding]; other site 717785002461 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 717785002462 GTP-binding protein YchF; Reviewed; Region: PRK09601 717785002463 YchF GTPase; Region: YchF; cd01900 717785002464 G1 box; other site 717785002465 GTP/Mg2+ binding site [chemical binding]; other site 717785002466 Switch I region; other site 717785002467 G2 box; other site 717785002468 Switch II region; other site 717785002469 G3 box; other site 717785002470 G4 box; other site 717785002471 G5 box; other site 717785002472 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 717785002473 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 717785002474 putative active site [active] 717785002475 catalytic residue [active] 717785002476 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 717785002477 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 717785002478 5S rRNA interface [nucleotide binding]; other site 717785002479 CTC domain interface [polypeptide binding]; other site 717785002480 L16 interface [polypeptide binding]; other site 717785002481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785002482 metal binding site 2 [ion binding]; metal-binding site 717785002483 putative DNA binding helix; other site 717785002484 metal binding site 1 [ion binding]; metal-binding site 717785002485 dimer interface [polypeptide binding]; other site 717785002486 structural Zn2+ binding site [ion binding]; other site 717785002487 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 717785002488 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 717785002489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785002490 active site 717785002491 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 717785002492 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 717785002493 Uncharacterized conserved protein [Function unknown]; Region: COG1565 717785002494 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 717785002495 Membrane fusogenic activity; Region: BMFP; pfam04380 717785002496 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 717785002497 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 717785002498 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 717785002499 HAMP domain; Region: HAMP; pfam00672 717785002500 dimerization interface [polypeptide binding]; other site 717785002501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785002502 dimer interface [polypeptide binding]; other site 717785002503 phosphorylation site [posttranslational modification] 717785002504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002505 ATP binding site [chemical binding]; other site 717785002506 Mg2+ binding site [ion binding]; other site 717785002507 G-X-G motif; other site 717785002508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002510 active site 717785002511 phosphorylation site [posttranslational modification] 717785002512 intermolecular recognition site; other site 717785002513 dimerization interface [polypeptide binding]; other site 717785002514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785002515 DNA binding site [nucleotide binding] 717785002516 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785002517 MarR family; Region: MarR_2; pfam12802 717785002518 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 717785002519 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 717785002520 homodimer interface [polypeptide binding]; other site 717785002521 substrate-cofactor binding pocket; other site 717785002522 catalytic residue [active] 717785002523 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 717785002524 dimer interface [polypeptide binding]; other site 717785002525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785002526 ligand binding site [chemical binding]; other site 717785002527 hypothetical protein; Provisional; Region: PRK09256 717785002528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785002529 S-adenosylmethionine binding site [chemical binding]; other site 717785002530 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 717785002531 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 717785002532 Ligand Binding Site [chemical binding]; other site 717785002533 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 717785002534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785002535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002536 active site 717785002537 phosphorylation site [posttranslational modification] 717785002538 intermolecular recognition site; other site 717785002539 dimerization interface [polypeptide binding]; other site 717785002540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785002541 DNA binding site [nucleotide binding] 717785002542 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 717785002543 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 717785002544 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 717785002545 catalytic core [active] 717785002546 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 717785002547 catalytic core [active] 717785002548 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 717785002549 intracellular protease, PfpI family; Region: PfpI; TIGR01382 717785002550 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 717785002551 proposed catalytic triad [active] 717785002552 conserved cys residue [active] 717785002553 excinuclease ABC subunit B; Provisional; Region: PRK05298 717785002554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785002555 ATP binding site [chemical binding]; other site 717785002556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002557 nucleotide binding region [chemical binding]; other site 717785002558 ATP-binding site [chemical binding]; other site 717785002559 Ultra-violet resistance protein B; Region: UvrB; pfam12344 717785002560 UvrB/uvrC motif; Region: UVR; pfam02151 717785002561 short chain dehydrogenase; Provisional; Region: PRK12828 717785002562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002563 NAD(P) binding site [chemical binding]; other site 717785002564 active site 717785002565 aspartate aminotransferase; Provisional; Region: PRK05764 717785002566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785002567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785002568 homodimer interface [polypeptide binding]; other site 717785002569 catalytic residue [active] 717785002570 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 717785002571 elongation factor G; Reviewed; Region: PRK12740 717785002572 G1 box; other site 717785002573 putative GEF interaction site [polypeptide binding]; other site 717785002574 GTP/Mg2+ binding site [chemical binding]; other site 717785002575 Switch I region; other site 717785002576 G2 box; other site 717785002577 G3 box; other site 717785002578 Switch II region; other site 717785002579 G4 box; other site 717785002580 G5 box; other site 717785002581 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 717785002582 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 717785002583 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 717785002584 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 717785002585 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 717785002586 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 717785002587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785002588 catalytic loop [active] 717785002589 iron binding site [ion binding]; other site 717785002590 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 717785002591 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 717785002592 [4Fe-4S] binding site [ion binding]; other site 717785002593 molybdopterin cofactor binding site; other site 717785002594 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 717785002595 molybdopterin cofactor binding site; other site 717785002596 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 717785002597 putative dimer interface [polypeptide binding]; other site 717785002598 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 717785002599 SLBB domain; Region: SLBB; pfam10531 717785002600 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 717785002601 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 717785002602 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 717785002603 putative dimer interface [polypeptide binding]; other site 717785002604 [2Fe-2S] cluster binding site [ion binding]; other site 717785002605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785002606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785002607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785002608 dimerization interface [polypeptide binding]; other site 717785002609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002610 NAD(P) binding site [chemical binding]; other site 717785002611 active site 717785002612 EAL domain; Region: EAL; pfam00563 717785002613 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 717785002614 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 717785002615 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 717785002616 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 717785002617 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 717785002618 NAD(P) binding site [chemical binding]; other site 717785002619 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 717785002620 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 717785002621 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 717785002622 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 717785002623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785002624 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 717785002625 Walker A/P-loop; other site 717785002626 ATP binding site [chemical binding]; other site 717785002627 Q-loop/lid; other site 717785002628 ABC transporter signature motif; other site 717785002629 Walker B; other site 717785002630 D-loop; other site 717785002631 H-loop/switch region; other site 717785002632 hypothetical protein; Validated; Region: PRK09039 717785002633 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002634 ligand binding site [chemical binding]; other site 717785002635 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 717785002636 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 717785002637 active site 717785002638 dimerization interface [polypeptide binding]; other site 717785002639 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785002640 Sel1-like repeats; Region: SEL1; smart00671 717785002641 Sel1-like repeats; Region: SEL1; smart00671 717785002642 Sel1-like repeats; Region: SEL1; smart00671 717785002643 Sel1-like repeats; Region: SEL1; smart00671 717785002644 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 717785002645 active site 717785002646 thiamine phosphate binding site [chemical binding]; other site 717785002647 pyrophosphate binding site [ion binding]; other site 717785002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785002649 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785002650 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785002651 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 717785002652 active site 717785002653 intersubunit interface [polypeptide binding]; other site 717785002654 catalytic residue [active] 717785002655 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 717785002656 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 717785002657 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 717785002658 Cell division protein ZapA; Region: ZapA; pfam05164 717785002659 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 717785002660 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 717785002661 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 717785002662 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785002663 putative active site [active] 717785002664 metal binding site [ion binding]; metal-binding site 717785002665 homodimer binding site [polypeptide binding]; other site 717785002666 hypothetical protein; Validated; Region: PRK00110 717785002667 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 717785002668 active site 717785002669 putative DNA-binding cleft [nucleotide binding]; other site 717785002670 dimer interface [polypeptide binding]; other site 717785002671 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 717785002672 RuvA N terminal domain; Region: RuvA_N; pfam01330 717785002673 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 717785002674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002675 Walker A motif; other site 717785002676 ATP binding site [chemical binding]; other site 717785002677 Walker B motif; other site 717785002678 arginine finger; other site 717785002679 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 717785002680 phosphodiesterase YaeI; Provisional; Region: PRK11340 717785002681 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 717785002682 putative active site [active] 717785002683 putative metal binding site [ion binding]; other site 717785002684 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 717785002685 active site 717785002686 TolQ protein; Region: tolQ; TIGR02796 717785002687 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 717785002688 TolR protein; Region: tolR; TIGR02801 717785002689 translocation protein TolB; Provisional; Region: tolB; PRK05137 717785002690 TolB amino-terminal domain; Region: TolB_N; pfam04052 717785002691 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002692 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002693 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002694 putative outer membrane lipoprotein; Provisional; Region: PRK09967 717785002695 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002696 ligand binding site [chemical binding]; other site 717785002697 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 717785002698 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002699 ligand binding site [chemical binding]; other site 717785002700 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 717785002701 Tetratricopeptide repeat; Region: TPR_6; pfam13174 717785002702 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 717785002703 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 717785002704 Ligand Binding Site [chemical binding]; other site 717785002705 FtsH Extracellular; Region: FtsH_ext; pfam06480 717785002706 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 717785002707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002708 Walker A motif; other site 717785002709 ATP binding site [chemical binding]; other site 717785002710 Walker B motif; other site 717785002711 arginine finger; other site 717785002712 Peptidase family M41; Region: Peptidase_M41; pfam01434 717785002713 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 717785002714 dihydropteroate synthase; Region: DHPS; TIGR01496 717785002715 substrate binding pocket [chemical binding]; other site 717785002716 dimer interface [polypeptide binding]; other site 717785002717 inhibitor binding site; inhibition site 717785002718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785002719 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 717785002720 putative C-terminal domain interface [polypeptide binding]; other site 717785002721 putative GSH binding site (G-site) [chemical binding]; other site 717785002722 putative dimer interface [polypeptide binding]; other site 717785002723 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 717785002724 putative N-terminal domain interface [polypeptide binding]; other site 717785002725 putative dimer interface [polypeptide binding]; other site 717785002726 putative substrate binding pocket (H-site) [chemical binding]; other site 717785002727 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717785002728 amino acid transporter; Region: 2A0306; TIGR00909 717785002729 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785002730 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785002731 P-loop; other site 717785002732 Magnesium ion binding site [ion binding]; other site 717785002733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785002734 Magnesium ion binding site [ion binding]; other site 717785002735 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 717785002736 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 717785002737 active site 717785002738 substrate binding site [chemical binding]; other site 717785002739 metal binding site [ion binding]; metal-binding site 717785002740 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 717785002741 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 717785002742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002743 catalytic residue [active] 717785002744 conserved hypothetical protein; Region: TIGR02231 717785002745 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 717785002746 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 717785002747 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 717785002748 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 717785002749 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 717785002750 GDP-binding site [chemical binding]; other site 717785002751 ACT binding site; other site 717785002752 IMP binding site; other site 717785002753 Uncharacterized conserved protein [Function unknown]; Region: COG1434 717785002754 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717785002755 putative active site [active] 717785002756 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002757 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002758 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002759 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002760 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785002762 Coenzyme A binding pocket [chemical binding]; other site 717785002763 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717785002764 nudix motif; other site 717785002765 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 717785002766 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 717785002767 putative active site [active] 717785002768 putative metal binding site [ion binding]; other site 717785002769 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785002770 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785002771 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785002772 active site 717785002773 nucleophile elbow; other site 717785002774 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785002775 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 717785002776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785002777 non-specific DNA binding site [nucleotide binding]; other site 717785002778 salt bridge; other site 717785002779 sequence-specific DNA binding site [nucleotide binding]; other site 717785002780 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 717785002781 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785002782 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 717785002783 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785002784 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 717785002785 Zinc knuckle; Region: zf-CCHC_3; pfam13917 717785002786 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 717785002787 Chromate transporter; Region: Chromate_transp; pfam02417 717785002788 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 717785002789 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 717785002790 Cl binding site [ion binding]; other site 717785002791 oligomer interface [polypeptide binding]; other site 717785002792 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717785002793 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785002794 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 717785002795 NodB motif; other site 717785002796 active site 717785002797 catalytic site [active] 717785002798 metal binding site [ion binding]; metal-binding site 717785002799 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 717785002800 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785002801 putative C-terminal domain interface [polypeptide binding]; other site 717785002802 putative GSH binding site [chemical binding]; other site 717785002803 putative dimer interface [polypeptide binding]; other site 717785002804 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 717785002805 putative N-terminal domain interface [polypeptide binding]; other site 717785002806 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 717785002807 ThiC-associated domain; Region: ThiC-associated; pfam13667 717785002808 ThiC family; Region: ThiC; pfam01964 717785002809 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 717785002810 Zn binding site [ion binding]; other site 717785002811 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 717785002812 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785002813 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 717785002814 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 717785002815 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 717785002816 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 717785002817 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 717785002818 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 717785002819 Protein of unknown function DUF58; Region: DUF58; pfam01882 717785002820 MoxR-like ATPases [General function prediction only]; Region: COG0714 717785002821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002822 Walker A motif; other site 717785002823 ATP binding site [chemical binding]; other site 717785002824 Walker B motif; other site 717785002825 arginine finger; other site 717785002826 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 717785002827 Protein of unknown function DUF262; Region: DUF262; pfam03235 717785002828 Uncharacterized conserved protein [Function unknown]; Region: COG1479 717785002829 Herpesvirus UL14-like protein; Region: Herpes_UL14; cl17291 717785002830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717785002831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785002832 Coenzyme A binding pocket [chemical binding]; other site 717785002833 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785002834 DNA-binding site [nucleotide binding]; DNA binding site 717785002835 RNA-binding motif; other site 717785002836 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785002837 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 717785002838 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 717785002839 Multicopper oxidase; Region: Cu-oxidase; pfam00394 717785002840 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 717785002841 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 717785002842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785002843 Histidine kinase; Region: HisKA_2; pfam07568 717785002844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002845 ATP binding site [chemical binding]; other site 717785002846 Mg2+ binding site [ion binding]; other site 717785002847 G-X-G motif; other site 717785002848 Usg-like family; Region: Usg; cl11567 717785002849 MarC family integral membrane protein; Region: MarC; pfam01914 717785002850 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 717785002851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785002852 Coenzyme A binding pocket [chemical binding]; other site 717785002853 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717785002854 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 717785002855 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 717785002856 catalytic triad [active] 717785002857 Protein of unknown function; Region: DUF3971; pfam13116 717785002858 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 717785002859 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 717785002860 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 717785002861 active site 717785002862 HIGH motif; other site 717785002863 dimer interface [polypeptide binding]; other site 717785002864 KMSKS motif; other site 717785002865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 717785002866 RNA binding surface [nucleotide binding]; other site 717785002867 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 717785002868 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 717785002869 Predicted transcriptional regulator [Transcription]; Region: COG1959 717785002870 Transcriptional regulator; Region: Rrf2; cl17282 717785002871 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 717785002872 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 717785002873 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002874 catalytic residue [active] 717785002875 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 717785002876 putative ABC transporter; Region: ycf24; CHL00085 717785002877 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 717785002878 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 717785002879 Walker A/P-loop; other site 717785002880 ATP binding site [chemical binding]; other site 717785002881 Q-loop/lid; other site 717785002882 ABC transporter signature motif; other site 717785002883 Walker B; other site 717785002884 D-loop; other site 717785002885 H-loop/switch region; other site 717785002886 FeS assembly protein SufD; Region: sufD; TIGR01981 717785002887 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 717785002888 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785002889 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785002890 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002891 catalytic residue [active] 717785002892 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 717785002893 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 717785002894 TfoX N-terminal domain; Region: TfoX_N; pfam04993 717785002895 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 717785002896 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 717785002897 ATP binding site [chemical binding]; other site 717785002898 Mg++ binding site [ion binding]; other site 717785002899 motif III; other site 717785002900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002901 nucleotide binding region [chemical binding]; other site 717785002902 ATP-binding site [chemical binding]; other site 717785002903 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 717785002904 amphipathic channel; other site 717785002905 Asn-Pro-Ala signature motifs; other site 717785002906 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 717785002907 Fatty acid desaturase; Region: FA_desaturase; pfam00487 717785002908 putative di-iron ligands [ion binding]; other site 717785002909 Fatty acid desaturase; Region: FA_desaturase; pfam00487 717785002910 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 717785002911 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 717785002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002913 Mg2+ binding site [ion binding]; other site 717785002914 G-X-G motif; other site 717785002915 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 717785002916 anchoring element; other site 717785002917 dimer interface [polypeptide binding]; other site 717785002918 ATP binding site [chemical binding]; other site 717785002919 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 717785002920 active site 717785002921 putative metal-binding site [ion binding]; other site 717785002922 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717785002923 Pantoate-beta-alanine ligase; Region: PanC; cd00560 717785002924 pantoate--beta-alanine ligase; Region: panC; TIGR00018 717785002925 active site 717785002926 ATP-binding site [chemical binding]; other site 717785002927 pantoate-binding site; other site 717785002928 HXXH motif; other site 717785002929 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 717785002930 Proline dehydrogenase; Region: Pro_dh; cl03282 717785002931 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 717785002932 Glutamate binding site [chemical binding]; other site 717785002933 NAD binding site [chemical binding]; other site 717785002934 catalytic residues [active] 717785002935 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 717785002936 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717785002937 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717785002938 Sporulation related domain; Region: SPOR; pfam05036 717785002939 Uncharacterized conserved protein [Function unknown]; Region: COG2127 717785002940 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 717785002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002942 Walker A motif; other site 717785002943 ATP binding site [chemical binding]; other site 717785002944 Walker B motif; other site 717785002945 arginine finger; other site 717785002946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785002947 Walker A motif; other site 717785002948 ATP binding site [chemical binding]; other site 717785002949 Walker B motif; other site 717785002950 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785002951 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 717785002952 NADH(P)-binding; Region: NAD_binding_10; pfam13460 717785002953 NAD binding site [chemical binding]; other site 717785002954 substrate binding site [chemical binding]; other site 717785002955 putative active site [active] 717785002956 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 717785002957 HIT family signature motif; other site 717785002958 catalytic residue [active] 717785002959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 717785002960 Protein of unknown function, DUF482; Region: DUF482; pfam04339 717785002961 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 717785002962 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 717785002963 active site 717785002964 catalytic site [active] 717785002965 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 717785002966 homotrimer interaction site [polypeptide binding]; other site 717785002967 putative active site [active] 717785002968 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 717785002969 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 717785002970 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785002971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002972 active site 717785002973 phosphorylation site [posttranslational modification] 717785002974 intermolecular recognition site; other site 717785002975 dimerization interface [polypeptide binding]; other site 717785002976 response regulator PleD; Reviewed; Region: pleD; PRK09581 717785002977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002978 active site 717785002979 phosphorylation site [posttranslational modification] 717785002980 intermolecular recognition site; other site 717785002981 dimerization interface [polypeptide binding]; other site 717785002982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785002983 active site 717785002984 phosphorylation site [posttranslational modification] 717785002985 intermolecular recognition site; other site 717785002986 dimerization interface [polypeptide binding]; other site 717785002987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785002988 metal binding site [ion binding]; metal-binding site 717785002989 active site 717785002990 I-site; other site 717785002991 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 717785002992 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 717785002993 nudix motif; other site 717785002994 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785002995 ribonuclease R; Region: RNase_R; TIGR02063 717785002996 RNB domain; Region: RNB; pfam00773 717785002997 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 717785002998 RNA binding site [nucleotide binding]; other site 717785002999 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 717785003000 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 717785003001 active site 717785003002 interdomain interaction site; other site 717785003003 putative metal-binding site [ion binding]; other site 717785003004 nucleotide binding site [chemical binding]; other site 717785003005 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 717785003006 domain I; other site 717785003007 DNA binding groove [nucleotide binding] 717785003008 phosphate binding site [ion binding]; other site 717785003009 domain II; other site 717785003010 domain III; other site 717785003011 nucleotide binding site [chemical binding]; other site 717785003012 catalytic site [active] 717785003013 domain IV; other site 717785003014 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 717785003015 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 717785003016 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 717785003017 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 717785003018 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 717785003019 DNA protecting protein DprA; Region: dprA; TIGR00732 717785003020 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 717785003021 dihydroorotase; Validated; Region: PRK09059 717785003022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 717785003023 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 717785003024 active site 717785003025 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 717785003026 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785003027 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785003028 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 717785003029 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 717785003030 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 717785003031 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 717785003032 Chorismate mutase type II; Region: CM_2; smart00830 717785003033 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 717785003034 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 717785003035 GatB domain; Region: GatB_Yqey; smart00845 717785003036 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 717785003037 Cytochrome P450; Region: p450; cl12078 717785003038 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 717785003039 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 717785003040 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 717785003041 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 717785003042 NADP binding site [chemical binding]; other site 717785003043 dimer interface [polypeptide binding]; other site 717785003044 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 717785003045 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 717785003046 C-terminal domain interface [polypeptide binding]; other site 717785003047 GSH binding site (G-site) [chemical binding]; other site 717785003048 dimer interface [polypeptide binding]; other site 717785003049 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 717785003050 N-terminal domain interface [polypeptide binding]; other site 717785003051 dimer interface [polypeptide binding]; other site 717785003052 substrate binding pocket (H-site) [chemical binding]; other site 717785003053 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785003054 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 717785003055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003056 active site 717785003057 phosphorylation site [posttranslational modification] 717785003058 intermolecular recognition site; other site 717785003059 dimerization interface [polypeptide binding]; other site 717785003060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785003061 DNA binding residues [nucleotide binding] 717785003062 dimerization interface [polypeptide binding]; other site 717785003063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785003064 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785003065 putative active site [active] 717785003066 heme pocket [chemical binding]; other site 717785003067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003068 dimer interface [polypeptide binding]; other site 717785003069 phosphorylation site [posttranslational modification] 717785003070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003071 ATP binding site [chemical binding]; other site 717785003072 Mg2+ binding site [ion binding]; other site 717785003073 G-X-G motif; other site 717785003074 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 717785003075 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 717785003076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 717785003077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 717785003078 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785003079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785003080 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 717785003081 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785003082 catalytic loop [active] 717785003083 iron binding site [ion binding]; other site 717785003084 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785003085 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785003086 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785003087 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785003088 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785003089 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785003090 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785003091 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785003092 Cytochrome c; Region: Cytochrom_C; pfam00034 717785003093 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 717785003094 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 717785003095 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 717785003096 BON domain; Region: BON; pfam04972 717785003097 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 717785003098 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785003099 ligand binding site [chemical binding]; other site 717785003100 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785003101 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785003102 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785003103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785003104 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 717785003105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 717785003106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 717785003107 catalytic residue [active] 717785003108 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785003109 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 717785003110 dimer interface [polypeptide binding]; other site 717785003111 active site 717785003112 catalytic residue [active] 717785003113 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 717785003114 SmpB-tmRNA interface; other site 717785003115 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 717785003116 catalytic triad [active] 717785003117 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 717785003118 Fe-S cluster binding site [ion binding]; other site 717785003119 DNA binding site [nucleotide binding] 717785003120 active site 717785003121 Uncharacterized conserved protein [Function unknown]; Region: COG1432 717785003122 LabA_like proteins; Region: LabA; cd10911 717785003123 putative metal binding site [ion binding]; other site 717785003124 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 717785003125 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 717785003126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717785003127 Zn2+ binding site [ion binding]; other site 717785003128 Mg2+ binding site [ion binding]; other site 717785003129 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 717785003130 synthetase active site [active] 717785003131 NTP binding site [chemical binding]; other site 717785003132 metal binding site [ion binding]; metal-binding site 717785003133 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 717785003134 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 717785003135 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 717785003136 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 717785003137 active site 717785003138 hydrophilic channel; other site 717785003139 dimerization interface [polypeptide binding]; other site 717785003140 catalytic residues [active] 717785003141 active site lid [active] 717785003142 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 717785003143 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 717785003144 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 717785003145 Catalytic site [active] 717785003146 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 717785003147 ribonuclease III; Reviewed; Region: rnc; PRK00102 717785003148 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 717785003149 dimerization interface [polypeptide binding]; other site 717785003150 active site 717785003151 metal binding site [ion binding]; metal-binding site 717785003152 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 717785003153 dsRNA binding site [nucleotide binding]; other site 717785003154 GTPase Era; Reviewed; Region: era; PRK00089 717785003155 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 717785003156 G1 box; other site 717785003157 GTP/Mg2+ binding site [chemical binding]; other site 717785003158 Switch I region; other site 717785003159 G2 box; other site 717785003160 Switch II region; other site 717785003161 G3 box; other site 717785003162 G4 box; other site 717785003163 G5 box; other site 717785003164 KH domain; Region: KH_2; pfam07650 717785003165 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 717785003166 Recombination protein O N terminal; Region: RecO_N; pfam11967 717785003167 Recombination protein O C terminal; Region: RecO_C; pfam02565 717785003168 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 717785003169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785003170 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 717785003171 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 717785003172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 717785003173 carboxyltransferase (CT) interaction site; other site 717785003174 biotinylation site [posttranslational modification]; other site 717785003175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785003176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785003177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785003178 dimerization interface [polypeptide binding]; other site 717785003179 lipoate-protein ligase B; Provisional; Region: PRK14341 717785003180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785003181 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 717785003182 active site 717785003183 catalytic residues [active] 717785003184 DNA binding site [nucleotide binding] 717785003185 Int/Topo IB signature motif; other site 717785003186 Helix-turn-helix domain; Region: HTH_17; pfam12728 717785003187 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 717785003188 Protein of unknown function (DUF968); Region: DUF968; pfam06147 717785003189 ERF superfamily; Region: ERF; pfam04404 717785003190 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785003191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785003192 non-specific DNA binding site [nucleotide binding]; other site 717785003193 salt bridge; other site 717785003194 sequence-specific DNA binding site [nucleotide binding]; other site 717785003195 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 717785003196 Catalytic site [active] 717785003197 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 717785003198 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 717785003199 DNA-binding interface [nucleotide binding]; DNA binding site 717785003200 Phage terminase large subunit; Region: Terminase_3; cl12054 717785003201 Terminase-like family; Region: Terminase_6; pfam03237 717785003202 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 717785003203 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 717785003204 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 717785003205 catalytic residue [active] 717785003206 T5orf172 domain; Region: T5orf172; pfam10544 717785003207 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003208 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003209 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785003210 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 717785003211 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 717785003212 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785003213 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785003214 active site 717785003215 nucleophile elbow; other site 717785003216 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 717785003217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785003218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785003219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003220 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003221 active site 717785003222 phosphorylation site [posttranslational modification] 717785003223 intermolecular recognition site; other site 717785003224 dimerization interface [polypeptide binding]; other site 717785003225 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785003226 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717785003227 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785003228 protein binding site [polypeptide binding]; other site 717785003229 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785003230 Predicted membrane protein [Function unknown]; Region: COG4803 717785003231 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 717785003232 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785003233 NodB motif; other site 717785003234 active site 717785003235 catalytic site [active] 717785003236 metal binding site [ion binding]; metal-binding site 717785003237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717785003238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785003239 Coenzyme A binding pocket [chemical binding]; other site 717785003240 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 717785003241 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 717785003242 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 717785003243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785003244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785003245 homodimer interface [polypeptide binding]; other site 717785003246 catalytic residue [active] 717785003247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785003248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785003249 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 717785003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785003252 putative substrate translocation pore; other site 717785003253 glutamine synthetase; Provisional; Region: glnA; PRK09469 717785003254 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 717785003255 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785003256 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 717785003257 Nitrogen regulatory protein P-II; Region: P-II; smart00938 717785003258 Uncharacterized conserved protein [Function unknown]; Region: COG0062 717785003259 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 717785003260 putative substrate binding site [chemical binding]; other site 717785003261 putative ATP binding site [chemical binding]; other site 717785003262 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 717785003263 active site 717785003264 TPR repeat; Region: TPR_11; pfam13414 717785003265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003266 TPR motif; other site 717785003267 TPR repeat; Region: TPR_11; pfam13414 717785003268 binding surface 717785003269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003270 binding surface 717785003271 TPR motif; other site 717785003272 TPR repeat; Region: TPR_11; pfam13414 717785003273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003274 TPR motif; other site 717785003275 TPR repeat; Region: TPR_11; pfam13414 717785003276 binding surface 717785003277 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 717785003278 DNA photolyase; Region: DNA_photolyase; pfam00875 717785003279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 717785003280 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785003281 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 717785003282 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 717785003283 active site 1 [active] 717785003284 active site 2 [active] 717785003285 methionine sulfoxide reductase B; Provisional; Region: PRK00222 717785003286 SelR domain; Region: SelR; pfam01641 717785003287 Protein of unknown function DUF72; Region: DUF72; pfam01904 717785003288 TonB C terminal; Region: TonB_2; pfam13103 717785003289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785003290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785003291 metal binding site [ion binding]; metal-binding site 717785003292 active site 717785003293 I-site; other site 717785003294 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785003295 short chain dehydrogenase; Provisional; Region: PRK06914 717785003296 NADP binding site [chemical binding]; other site 717785003297 active site 717785003298 steroid binding site; other site 717785003299 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 717785003300 active site clefts [active] 717785003301 zinc binding site [ion binding]; other site 717785003302 dimer interface [polypeptide binding]; other site 717785003303 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717785003304 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 717785003305 Beta-lactamase; Region: Beta-lactamase; pfam00144 717785003306 Cytochrome c; Region: Cytochrom_C; pfam00034 717785003307 Cytochrome c; Region: Cytochrom_C; cl11414 717785003308 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785003309 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 717785003310 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785003311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785003312 motif II; other site 717785003313 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785003314 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003315 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785003316 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003317 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 717785003318 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 717785003319 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717785003320 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 717785003321 high affinity sulphate transporter 1; Region: sulP; TIGR00815 717785003322 Sulfate transporter family; Region: Sulfate_transp; pfam00916 717785003323 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 717785003324 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 717785003325 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 717785003326 PhnA protein; Region: PhnA; pfam03831 717785003327 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 717785003328 dimer interface [polypeptide binding]; other site 717785003329 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 717785003330 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 717785003331 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 717785003332 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 717785003333 putative cation:proton antiport protein; Provisional; Region: PRK10669 717785003334 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 717785003335 TrkA-N domain; Region: TrkA_N; pfam02254 717785003336 Uncharacterized conserved protein [Function unknown]; Region: COG3791 717785003337 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 717785003338 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 717785003339 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 717785003340 dimer interface [polypeptide binding]; other site 717785003341 ssDNA binding site [nucleotide binding]; other site 717785003342 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785003343 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717785003344 Cation efflux family; Region: Cation_efflux; pfam01545 717785003345 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 717785003346 active site 717785003347 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 717785003348 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785003349 putative switch regulator; other site 717785003350 non-specific DNA interactions [nucleotide binding]; other site 717785003351 DNA binding site [nucleotide binding] 717785003352 sequence specific DNA binding site [nucleotide binding]; other site 717785003353 putative cAMP binding site [chemical binding]; other site 717785003354 DNA gyrase subunit A; Validated; Region: PRK05560 717785003355 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 717785003356 CAP-like domain; other site 717785003357 active site 717785003358 primary dimer interface [polypeptide binding]; other site 717785003359 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003362 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003363 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003364 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003365 Cytochrome c; Region: Cytochrom_C; cl11414 717785003366 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 717785003367 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 717785003368 active site 717785003369 (T/H)XGH motif; other site 717785003370 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 717785003371 active site 717785003372 DNA binding site [nucleotide binding] 717785003373 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717785003374 active site 717785003375 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717785003376 active site 717785003377 Protein of unknown function (DUF423); Region: DUF423; cl01008 717785003378 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 717785003379 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 717785003380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785003381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785003382 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 717785003383 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 717785003384 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 717785003385 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 717785003386 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 717785003387 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 717785003388 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 717785003389 ChaB; Region: ChaB; pfam06150 717785003390 Uncharacterized conserved protein [Function unknown]; Region: COG3791 717785003391 MASE1; Region: MASE1; cl17823 717785003392 PAS fold; Region: PAS_7; pfam12860 717785003393 PAS domain S-box; Region: sensory_box; TIGR00229 717785003394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785003395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785003396 metal binding site [ion binding]; metal-binding site 717785003397 active site 717785003398 I-site; other site 717785003399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785003400 Phospholipid methyltransferase; Region: PEMT; cl17370 717785003401 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 717785003402 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 717785003403 malonyl-CoA binding site [chemical binding]; other site 717785003404 dimer interface [polypeptide binding]; other site 717785003405 active site 717785003406 product binding site; other site 717785003407 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785003408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003409 putative substrate translocation pore; other site 717785003410 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 717785003411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003412 NAD(P) binding site [chemical binding]; other site 717785003413 active site 717785003414 acetoacetate decarboxylase; Provisional; Region: PRK02265 717785003415 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785003416 nucleophile elbow; other site 717785003417 Patatin phospholipase; Region: DUF3734; pfam12536 717785003418 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003420 putative substrate translocation pore; other site 717785003421 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 717785003422 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785003423 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785003425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785003426 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 717785003427 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 717785003428 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 717785003429 active site 717785003430 dimer interface [polypeptide binding]; other site 717785003431 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 717785003432 Ligand Binding Site [chemical binding]; other site 717785003433 Molecular Tunnel; other site 717785003434 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 717785003435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785003436 Walker A motif; other site 717785003437 ATP binding site [chemical binding]; other site 717785003438 Walker B motif; other site 717785003439 arginine finger; other site 717785003440 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 717785003441 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 717785003442 PAS domain; Region: PAS_9; pfam13426 717785003443 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785003444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003445 dimer interface [polypeptide binding]; other site 717785003446 phosphorylation site [posttranslational modification] 717785003447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003448 ATP binding site [chemical binding]; other site 717785003449 Mg2+ binding site [ion binding]; other site 717785003450 G-X-G motif; other site 717785003451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003452 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003453 active site 717785003454 phosphorylation site [posttranslational modification] 717785003455 intermolecular recognition site; other site 717785003456 dimerization interface [polypeptide binding]; other site 717785003457 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 717785003458 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 717785003459 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 717785003460 hexamer interface [polypeptide binding]; other site 717785003461 Walker A motif; other site 717785003462 ATP binding site [chemical binding]; other site 717785003463 Walker B motif; other site 717785003464 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 717785003465 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 717785003466 motif 1; other site 717785003467 active site 717785003468 motif 2; other site 717785003469 motif 3; other site 717785003470 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 717785003471 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785003472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785003473 S-adenosylmethionine binding site [chemical binding]; other site 717785003474 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 717785003475 isocitrate dehydrogenase; Validated; Region: PRK08299 717785003476 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 717785003477 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 717785003478 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 717785003479 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 717785003480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785003481 RNA binding surface [nucleotide binding]; other site 717785003482 Paraquat-inducible protein A; Region: PqiA; pfam04403 717785003483 Paraquat-inducible protein A; Region: PqiA; pfam04403 717785003484 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 717785003485 homodimer interface [polypeptide binding]; other site 717785003486 homotetramer interface [polypeptide binding]; other site 717785003487 active site pocket [active] 717785003488 cleavage site 717785003489 MEKHLA domain; Region: MEKHLA; pfam08670 717785003490 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 717785003491 putative GSH binding site [chemical binding]; other site 717785003492 catalytic residues [active] 717785003493 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 717785003494 PqqA family; Region: PqqA; cl15372 717785003495 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 717785003496 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 717785003497 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 717785003498 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 717785003499 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 717785003500 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 717785003501 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 717785003502 dimerization interface [polypeptide binding]; other site 717785003503 ATP binding site [chemical binding]; other site 717785003504 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 717785003505 dimerization interface [polypeptide binding]; other site 717785003506 ATP binding site [chemical binding]; other site 717785003507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 717785003508 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 717785003509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785003510 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 717785003511 dimerization interface [polypeptide binding]; other site 717785003512 substrate binding pocket [chemical binding]; other site 717785003513 Predicted permeases [General function prediction only]; Region: COG0679 717785003514 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 717785003515 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 717785003516 putative active site [active] 717785003517 catalytic triad [active] 717785003518 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 717785003519 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 717785003520 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 717785003521 ATP binding site [chemical binding]; other site 717785003522 active site 717785003523 substrate binding site [chemical binding]; other site 717785003524 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 717785003525 Serine hydrolase; Region: Ser_hydrolase; pfam06821 717785003526 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 717785003527 dimerization interface [polypeptide binding]; other site 717785003528 metal binding site [ion binding]; metal-binding site 717785003529 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 717785003530 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 717785003531 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 717785003532 Ligand binding site; other site 717785003533 Putative Catalytic site; other site 717785003534 DXD motif; other site 717785003535 Predicted membrane protein [Function unknown]; Region: COG2246 717785003536 GtrA-like protein; Region: GtrA; pfam04138 717785003537 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785003538 active site 717785003539 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785003540 active site 717785003541 adenylosuccinate lyase; Provisional; Region: PRK07492 717785003542 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 717785003543 tetramer interface [polypeptide binding]; other site 717785003544 active site 717785003545 AAA domain; Region: AAA_17; pfam13207 717785003546 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 717785003547 amino acid transporter; Region: 2A0306; TIGR00909 717785003548 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 717785003549 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 717785003550 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 717785003551 Cl binding site [ion binding]; other site 717785003552 oligomer interface [polypeptide binding]; other site 717785003553 membrane ATPase/protein kinase; Provisional; Region: PRK09435 717785003554 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 717785003555 Walker A; other site 717785003556 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 717785003557 G4 box; other site 717785003558 G5 box; other site 717785003559 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 717785003560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 717785003561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785003562 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 717785003563 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 717785003564 Walker A/P-loop; other site 717785003565 ATP binding site [chemical binding]; other site 717785003566 Q-loop/lid; other site 717785003567 ABC transporter signature motif; other site 717785003568 Walker B; other site 717785003569 D-loop; other site 717785003570 H-loop/switch region; other site 717785003571 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 717785003572 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 717785003573 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 717785003574 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 717785003575 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 717785003576 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 717785003577 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 717785003578 PYR/PP interface [polypeptide binding]; other site 717785003579 dimer interface [polypeptide binding]; other site 717785003580 TPP binding site [chemical binding]; other site 717785003581 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785003582 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 717785003583 TPP-binding site [chemical binding]; other site 717785003584 dimer interface [polypeptide binding]; other site 717785003585 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 717785003586 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785003587 putative C-terminal domain interface [polypeptide binding]; other site 717785003588 putative GSH binding site (G-site) [chemical binding]; other site 717785003589 putative dimer interface [polypeptide binding]; other site 717785003590 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 717785003591 putative N-terminal domain interface [polypeptide binding]; other site 717785003592 putative dimer interface [polypeptide binding]; other site 717785003593 putative substrate binding pocket (H-site) [chemical binding]; other site 717785003594 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 717785003595 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 717785003596 putative valine binding site [chemical binding]; other site 717785003597 dimer interface [polypeptide binding]; other site 717785003598 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 717785003599 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 717785003600 ketol-acid reductoisomerase; Provisional; Region: PRK05479 717785003601 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 717785003602 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 717785003603 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 717785003604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785003605 N-terminal plug; other site 717785003606 ligand-binding site [chemical binding]; other site 717785003607 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 717785003608 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 717785003609 2-isopropylmalate synthase; Validated; Region: PRK00915 717785003610 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 717785003611 active site 717785003612 catalytic residues [active] 717785003613 metal binding site [ion binding]; metal-binding site 717785003614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 717785003615 rod shape-determining protein MreB; Provisional; Region: PRK13930 717785003616 MreB and similar proteins; Region: MreB_like; cd10225 717785003617 nucleotide binding site [chemical binding]; other site 717785003618 Mg binding site [ion binding]; other site 717785003619 putative protofilament interaction site [polypeptide binding]; other site 717785003620 RodZ interaction site [polypeptide binding]; other site 717785003621 rod shape-determining protein MreC; Provisional; Region: PRK13922 717785003622 rod shape-determining protein MreC; Region: MreC; pfam04085 717785003623 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 717785003624 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 717785003625 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 717785003626 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 717785003627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785003628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785003629 active site 717785003630 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 717785003631 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 717785003632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785003633 active site 717785003634 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 717785003635 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 717785003636 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003637 YtkA-like; Region: YtkA; pfam13115 717785003638 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785003639 DNA-binding site [nucleotide binding]; DNA binding site 717785003640 RNA-binding motif; other site 717785003641 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 717785003642 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 717785003643 Predicted deacylase [General function prediction only]; Region: COG3608 717785003644 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 717785003645 active site 717785003646 Zn binding site [ion binding]; other site 717785003647 Predicted transcriptional regulators [Transcription]; Region: COG1733 717785003648 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 717785003649 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785003650 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 717785003651 Trp docking motif [polypeptide binding]; other site 717785003652 active site 717785003653 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785003654 response regulator FixJ; Provisional; Region: fixJ; PRK09390 717785003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003656 active site 717785003657 phosphorylation site [posttranslational modification] 717785003658 intermolecular recognition site; other site 717785003659 dimerization interface [polypeptide binding]; other site 717785003660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785003661 DNA binding residues [nucleotide binding] 717785003662 dimerization interface [polypeptide binding]; other site 717785003663 MASE1; Region: MASE1; pfam05231 717785003664 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 717785003665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003666 dimer interface [polypeptide binding]; other site 717785003667 phosphorylation site [posttranslational modification] 717785003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003669 ATP binding site [chemical binding]; other site 717785003670 Mg2+ binding site [ion binding]; other site 717785003671 G-X-G motif; other site 717785003672 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785003673 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003674 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785003675 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003676 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 717785003677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003678 TPR repeat; Region: TPR_11; pfam13414 717785003679 binding surface 717785003680 TPR motif; other site 717785003681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003682 binding surface 717785003683 TPR repeat; Region: TPR_11; pfam13414 717785003684 TPR motif; other site 717785003685 TPR repeat; Region: TPR_11; pfam13414 717785003686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003687 TPR motif; other site 717785003688 binding surface 717785003689 TPR repeat; Region: TPR_11; pfam13414 717785003690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785003691 binding surface 717785003692 Tetratricopeptide repeat; Region: TPR_16; pfam13432 717785003693 TPR motif; other site 717785003694 Tetratricopeptide repeat; Region: TPR_16; pfam13432 717785003695 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 717785003696 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003697 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 717785003698 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 717785003699 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 717785003700 NADP binding site [chemical binding]; other site 717785003701 active site 717785003702 putative substrate binding site [chemical binding]; other site 717785003703 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 717785003704 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 717785003705 NADP-binding site; other site 717785003706 homotetramer interface [polypeptide binding]; other site 717785003707 substrate binding site [chemical binding]; other site 717785003708 homodimer interface [polypeptide binding]; other site 717785003709 active site 717785003710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003711 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785003712 putative substrate translocation pore; other site 717785003713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003714 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 717785003715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785003716 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003717 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 717785003718 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 717785003719 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 717785003720 CrcB-like protein; Region: CRCB; cl09114 717785003721 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785003722 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 717785003723 putative [4Fe-4S] binding site [ion binding]; other site 717785003724 putative molybdopterin cofactor binding site [chemical binding]; other site 717785003725 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 717785003726 molybdopterin cofactor binding site; other site 717785003727 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 717785003728 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717785003729 DXD motif; other site 717785003730 PilZ domain; Region: PilZ; pfam07238 717785003731 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 717785003732 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785003733 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 717785003734 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 717785003735 agmatinase; Region: agmatinase; TIGR01230 717785003736 oligomer interface [polypeptide binding]; other site 717785003737 putative active site [active] 717785003738 Mn binding site [ion binding]; other site 717785003739 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 717785003740 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 717785003741 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785003742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785003743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785003744 dimerization interface [polypeptide binding]; other site 717785003745 UreD urease accessory protein; Region: UreD; pfam01774 717785003746 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 717785003747 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 717785003748 alpha-gamma subunit interface [polypeptide binding]; other site 717785003749 beta-gamma subunit interface [polypeptide binding]; other site 717785003750 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 717785003751 gamma-beta subunit interface [polypeptide binding]; other site 717785003752 alpha-beta subunit interface [polypeptide binding]; other site 717785003753 urease subunit alpha; Reviewed; Region: ureC; PRK13207 717785003754 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 717785003755 subunit interactions [polypeptide binding]; other site 717785003756 active site 717785003757 flap region; other site 717785003758 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 717785003759 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 717785003760 dimer interface [polypeptide binding]; other site 717785003761 catalytic residues [active] 717785003762 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 717785003763 UreF; Region: UreF; pfam01730 717785003764 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 717785003765 G1 box; other site 717785003766 GTP/Mg2+ binding site [chemical binding]; other site 717785003767 Switch I region; other site 717785003768 G3 box; other site 717785003769 Switch II region; other site 717785003770 G4 box; other site 717785003771 G5 box; other site 717785003772 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 717785003773 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003775 active site 717785003776 phosphorylation site [posttranslational modification] 717785003777 intermolecular recognition site; other site 717785003778 dimerization interface [polypeptide binding]; other site 717785003779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785003780 DNA binding residues [nucleotide binding] 717785003781 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 717785003782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785003783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003784 dimer interface [polypeptide binding]; other site 717785003785 phosphorylation site [posttranslational modification] 717785003786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003787 ATP binding site [chemical binding]; other site 717785003788 Mg2+ binding site [ion binding]; other site 717785003789 G-X-G motif; other site 717785003790 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785003791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003792 active site 717785003793 phosphorylation site [posttranslational modification] 717785003794 intermolecular recognition site; other site 717785003795 dimerization interface [polypeptide binding]; other site 717785003796 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785003797 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 717785003798 putative ligand binding site [chemical binding]; other site 717785003799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717785003800 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785003801 TM-ABC transporter signature motif; other site 717785003802 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 717785003803 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785003804 TM-ABC transporter signature motif; other site 717785003805 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 717785003806 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 717785003807 Walker A/P-loop; other site 717785003808 ATP binding site [chemical binding]; other site 717785003809 Q-loop/lid; other site 717785003810 ABC transporter signature motif; other site 717785003811 Walker B; other site 717785003812 D-loop; other site 717785003813 H-loop/switch region; other site 717785003814 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 717785003815 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 717785003816 Walker A/P-loop; other site 717785003817 ATP binding site [chemical binding]; other site 717785003818 Q-loop/lid; other site 717785003819 ABC transporter signature motif; other site 717785003820 Walker B; other site 717785003821 D-loop; other site 717785003822 H-loop/switch region; other site 717785003823 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 717785003824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785003825 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 717785003826 putative heme binding pocket [chemical binding]; other site 717785003827 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 717785003828 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 717785003829 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 717785003830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785003831 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 717785003832 General stress protein [General function prediction only]; Region: GsiB; COG3729 717785003833 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 717785003834 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 717785003835 NAD(P) binding site [chemical binding]; other site 717785003836 catalytic residues [active] 717785003837 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003839 active site 717785003840 phosphorylation site [posttranslational modification] 717785003841 intermolecular recognition site; other site 717785003842 dimerization interface [polypeptide binding]; other site 717785003843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003844 dimer interface [polypeptide binding]; other site 717785003845 phosphorylation site [posttranslational modification] 717785003846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003847 ATP binding site [chemical binding]; other site 717785003848 Mg2+ binding site [ion binding]; other site 717785003849 G-X-G motif; other site 717785003850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003851 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003852 active site 717785003853 phosphorylation site [posttranslational modification] 717785003854 intermolecular recognition site; other site 717785003855 dimerization interface [polypeptide binding]; other site 717785003856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785003857 dimer interface [polypeptide binding]; other site 717785003858 phosphorylation site [posttranslational modification] 717785003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003860 ATP binding site [chemical binding]; other site 717785003861 G-X-G motif; other site 717785003862 Methyltransferase domain; Region: Methyltransf_25; pfam13649 717785003863 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785003865 active site 717785003866 phosphorylation site [posttranslational modification] 717785003867 intermolecular recognition site; other site 717785003868 dimerization interface [polypeptide binding]; other site 717785003869 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785003870 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785003871 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 717785003872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785003873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785003874 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 717785003875 Walker A/P-loop; other site 717785003876 ATP binding site [chemical binding]; other site 717785003877 Q-loop/lid; other site 717785003878 ABC transporter signature motif; other site 717785003879 Walker B; other site 717785003880 D-loop; other site 717785003881 H-loop/switch region; other site 717785003882 TOBE domain; Region: TOBE_2; pfam08402 717785003883 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785003885 dimer interface [polypeptide binding]; other site 717785003886 conserved gate region; other site 717785003887 putative PBP binding loops; other site 717785003888 ABC-ATPase subunit interface; other site 717785003889 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785003891 dimer interface [polypeptide binding]; other site 717785003892 conserved gate region; other site 717785003893 putative PBP binding loops; other site 717785003894 ABC-ATPase subunit interface; other site 717785003895 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 717785003896 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785003897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 717785003898 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 717785003899 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 717785003900 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785003901 putative [4Fe-4S] binding site [ion binding]; other site 717785003902 putative molybdopterin cofactor binding site [chemical binding]; other site 717785003903 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 717785003904 putative molybdopterin cofactor binding site; other site 717785003905 Transcription elongation factor Spt4; Region: Spt4; cl12033 717785003906 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 717785003907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785003908 FeS/SAM binding site; other site 717785003909 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 717785003910 Uncharacterized conserved protein [Function unknown]; Region: COG3791 717785003911 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 717785003912 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785003913 motif 1; other site 717785003914 dimer interface [polypeptide binding]; other site 717785003915 active site 717785003916 motif 2; other site 717785003917 motif 3; other site 717785003918 elongation factor P; Validated; Region: PRK00529 717785003919 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 717785003920 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 717785003921 RNA binding site [nucleotide binding]; other site 717785003922 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 717785003923 RNA binding site [nucleotide binding]; other site 717785003924 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785003925 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785003926 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 717785003927 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 717785003928 dimer interface [polypeptide binding]; other site 717785003929 putative functional site; other site 717785003930 putative MPT binding site; other site 717785003931 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 717785003932 trimer interface [polypeptide binding]; other site 717785003933 dimer interface [polypeptide binding]; other site 717785003934 putative active site [active] 717785003935 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 717785003936 active site 717785003937 ribulose/triose binding site [chemical binding]; other site 717785003938 phosphate binding site [ion binding]; other site 717785003939 substrate (anthranilate) binding pocket [chemical binding]; other site 717785003940 product (indole) binding pocket [chemical binding]; other site 717785003941 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 717785003942 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 717785003943 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 717785003944 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 717785003945 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 717785003946 glutamine binding [chemical binding]; other site 717785003947 catalytic triad [active] 717785003948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785003949 catalytic core [active] 717785003950 anthranilate synthase component I; Provisional; Region: PRK13573 717785003951 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 717785003952 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 717785003953 SurA N-terminal domain; Region: SurA_N_3; cl07813 717785003954 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 717785003955 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 717785003956 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 717785003957 triosephosphate isomerase; Provisional; Region: PRK14565 717785003958 substrate binding site [chemical binding]; other site 717785003959 dimer interface [polypeptide binding]; other site 717785003960 catalytic triad [active] 717785003961 Preprotein translocase SecG subunit; Region: SecG; cl09123 717785003962 CTP synthetase; Validated; Region: pyrG; PRK05380 717785003963 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 717785003964 Catalytic site [active] 717785003965 active site 717785003966 UTP binding site [chemical binding]; other site 717785003967 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 717785003968 active site 717785003969 putative oxyanion hole; other site 717785003970 catalytic triad [active] 717785003971 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717785003972 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 717785003973 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 717785003974 ABC-2 type transporter; Region: ABC2_membrane; cl17235 717785003975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785003976 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 717785003977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785003978 Walker A/P-loop; other site 717785003979 ATP binding site [chemical binding]; other site 717785003980 Q-loop/lid; other site 717785003981 ABC transporter signature motif; other site 717785003982 Walker B; other site 717785003983 D-loop; other site 717785003984 H-loop/switch region; other site 717785003985 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785003986 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 717785003987 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785003988 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785003989 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785003990 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785003991 ligand binding site [chemical binding]; other site 717785003992 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 717785003993 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785003994 membrane-bound complex binding site; other site 717785003995 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785003996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785003997 dimer interface [polypeptide binding]; other site 717785003998 conserved gate region; other site 717785003999 putative PBP binding loops; other site 717785004000 ABC-ATPase subunit interface; other site 717785004001 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785004002 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785004003 Walker A/P-loop; other site 717785004004 ATP binding site [chemical binding]; other site 717785004005 Q-loop/lid; other site 717785004006 ABC transporter signature motif; other site 717785004007 Walker B; other site 717785004008 D-loop; other site 717785004009 H-loop/switch region; other site 717785004010 hypothetical protein; Provisional; Region: PRK02227 717785004011 Dihydroneopterin aldolase; Region: FolB; pfam02152 717785004012 active site 717785004013 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 717785004014 nucleotide binding site [chemical binding]; other site 717785004015 substrate binding site [chemical binding]; other site 717785004016 Protein of unknown function (DUF447); Region: DUF447; pfam04289 717785004017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785004018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785004019 S-adenosylmethionine binding site [chemical binding]; other site 717785004020 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 717785004021 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 717785004022 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 717785004023 active site 717785004024 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 717785004025 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 717785004026 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 717785004027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785004028 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 717785004029 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 717785004030 trimer interface I [polypeptide binding]; other site 717785004031 putative substrate binding pocket [chemical binding]; other site 717785004032 trimer interface II [polypeptide binding]; other site 717785004033 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 717785004034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785004035 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 717785004036 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 717785004037 NAD(P) binding pocket [chemical binding]; other site 717785004038 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 717785004039 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 717785004040 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 717785004041 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 717785004042 aromatic arch; other site 717785004043 DCoH dimer interaction site [polypeptide binding]; other site 717785004044 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 717785004045 DCoH tetramer interaction site [polypeptide binding]; other site 717785004046 substrate binding site [chemical binding]; other site 717785004047 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 717785004048 catalytic center binding site [active] 717785004049 ATP binding site [chemical binding]; other site 717785004050 Cytochrome c2 [Energy production and conversion]; Region: COG3474 717785004051 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 717785004052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785004053 FeS/SAM binding site; other site 717785004054 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 717785004055 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 717785004056 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 717785004057 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 717785004058 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 717785004059 PqqA family; Region: PqqA; cl15372 717785004060 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 717785004061 Flavodoxin; Region: Flavodoxin_1; pfam00258 717785004062 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 717785004063 FAD binding pocket [chemical binding]; other site 717785004064 FAD binding motif [chemical binding]; other site 717785004065 catalytic residues [active] 717785004066 NAD binding pocket [chemical binding]; other site 717785004067 phosphate binding motif [ion binding]; other site 717785004068 beta-alpha-beta structure motif; other site 717785004069 sulfite reductase subunit beta; Provisional; Region: PRK13504 717785004070 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785004071 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785004072 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785004073 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 717785004074 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 717785004075 G1 box; other site 717785004076 putative GEF interaction site [polypeptide binding]; other site 717785004077 GTP/Mg2+ binding site [chemical binding]; other site 717785004078 Switch I region; other site 717785004079 G2 box; other site 717785004080 CysD dimerization site [polypeptide binding]; other site 717785004081 G3 box; other site 717785004082 Switch II region; other site 717785004083 G4 box; other site 717785004084 G5 box; other site 717785004085 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 717785004086 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 717785004087 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 717785004088 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 717785004089 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 717785004090 Active Sites [active] 717785004091 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 717785004092 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 717785004093 Active Sites [active] 717785004094 hypothetical protein; Provisional; Region: PRK07236 717785004095 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 717785004096 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 717785004097 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785004098 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 717785004099 dimer interface [polypeptide binding]; other site 717785004100 active site 717785004101 metal binding site [ion binding]; metal-binding site 717785004102 glutathione binding site [chemical binding]; other site 717785004103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785004104 DNA-binding site [nucleotide binding]; DNA binding site 717785004105 RNA-binding motif; other site 717785004106 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785004107 DNA-binding site [nucleotide binding]; DNA binding site 717785004108 RNA-binding motif; other site 717785004109 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 717785004110 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 717785004111 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 717785004112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004113 Domain of unknown function (DUF427); Region: DUF427; pfam04248 717785004114 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 717785004115 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 717785004116 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785004117 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004118 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004119 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785004120 YcgL domain; Region: YcgL; cl01189 717785004121 Protein export membrane protein; Region: SecD_SecF; cl14618 717785004122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785004123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785004124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785004125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785004126 dimerization interface [polypeptide binding]; other site 717785004127 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785004128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785004129 substrate binding pocket [chemical binding]; other site 717785004130 membrane-bound complex binding site; other site 717785004131 hinge residues; other site 717785004132 oxidase reductase; Provisional; Region: PTZ00273 717785004133 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 717785004134 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 717785004135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785004136 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 717785004137 TPP-binding site [chemical binding]; other site 717785004138 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 717785004139 PYR/PP interface [polypeptide binding]; other site 717785004140 dimer interface [polypeptide binding]; other site 717785004141 tetramer interface [polypeptide binding]; other site 717785004142 TPP binding site [chemical binding]; other site 717785004143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785004144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785004145 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785004146 putative effector binding pocket; other site 717785004147 dimerization interface [polypeptide binding]; other site 717785004148 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 717785004149 NmrA-like family; Region: NmrA; pfam05368 717785004150 putative NADP binding site [chemical binding]; other site 717785004151 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 717785004152 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785004153 active site 717785004154 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 717785004155 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 717785004156 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 717785004157 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 717785004158 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785004159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004160 active site 717785004161 phosphorylation site [posttranslational modification] 717785004162 intermolecular recognition site; other site 717785004163 dimerization interface [polypeptide binding]; other site 717785004164 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785004165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004166 active site 717785004167 phosphorylation site [posttranslational modification] 717785004168 intermolecular recognition site; other site 717785004169 dimerization interface [polypeptide binding]; other site 717785004170 Protein of unknown function (DUF461); Region: DUF461; pfam04314 717785004171 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 717785004172 Cytochrome c; Region: Cytochrom_C; pfam00034 717785004173 Cytochrome c; Region: Cytochrom_C; cl11414 717785004174 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785004175 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785004176 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785004177 Protein of unknown function (DUF962); Region: DUF962; pfam06127 717785004178 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785004179 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 717785004180 putative dimer interface [polypeptide binding]; other site 717785004181 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717785004182 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 717785004183 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 717785004184 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 717785004185 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 717785004186 cofactor binding site; other site 717785004187 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785004188 DNA methylase; Region: N6_N4_Mtase; cl17433 717785004189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 717785004190 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785004191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004193 DNA binding site [nucleotide binding] 717785004194 Predicted ATPase [General function prediction only]; Region: COG3903 717785004195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 717785004196 putative substrate translocation pore; other site 717785004197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785004198 EamA-like transporter family; Region: EamA; cl17759 717785004199 Domain of unknown function (DUF336); Region: DUF336; pfam03928 717785004200 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 717785004201 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 717785004202 potential catalytic triad [active] 717785004203 conserved cys residue [active] 717785004204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785004205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785004206 catalytic loop [active] 717785004207 iron binding site [ion binding]; other site 717785004208 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785004209 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785004210 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785004211 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785004212 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785004213 Family description; Region: DsbD_2; pfam13386 717785004214 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 717785004215 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717785004216 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 717785004217 metal-binding site [ion binding] 717785004218 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785004219 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 717785004220 FixH; Region: FixH; pfam05751 717785004221 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 717785004222 4Fe-4S binding domain; Region: Fer4_5; pfam12801 717785004223 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 717785004224 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 717785004225 Cytochrome c; Region: Cytochrom_C; pfam00034 717785004226 Cytochrome c; Region: Cytochrom_C; pfam00034 717785004227 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 717785004228 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 717785004229 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 717785004230 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 717785004231 Low-spin heme binding site [chemical binding]; other site 717785004232 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 717785004233 Putative water exit pathway; other site 717785004234 Binuclear center (active site) [active] 717785004235 Putative proton exit pathway; other site 717785004236 Sodium Bile acid symporter family; Region: SBF; cl17470 717785004237 bile acid transporter; Region: bass; TIGR00841 717785004238 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785004239 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785004240 ligand binding site [chemical binding]; other site 717785004241 flexible hinge region; other site 717785004242 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 717785004243 non-specific DNA interactions [nucleotide binding]; other site 717785004244 DNA binding site [nucleotide binding] 717785004245 sequence specific DNA binding site [nucleotide binding]; other site 717785004246 putative cAMP binding site [chemical binding]; other site 717785004247 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785004248 Sulfatase; Region: Sulfatase; cl17466 717785004249 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 717785004250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785004251 motif II; other site 717785004252 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 717785004253 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 717785004254 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004255 HlyD family secretion protein; Region: HlyD; pfam00529 717785004256 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004257 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 717785004258 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 717785004259 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 717785004260 heme-binding residues [chemical binding]; other site 717785004261 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 717785004262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785004263 binding surface 717785004264 TPR motif; other site 717785004265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785004266 TPR motif; other site 717785004267 binding surface 717785004268 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785004269 Sulfatase; Region: Sulfatase; pfam00884 717785004270 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785004271 Helix-turn-helix domain; Region: HTH_18; pfam12833 717785004272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004273 SET domain; Region: SET; pfam00856 717785004274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785004275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785004276 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 717785004277 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785004278 nucleophile elbow; other site 717785004279 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785004280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004281 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004282 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785004283 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 717785004284 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 717785004285 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 717785004286 FAD binding pocket [chemical binding]; other site 717785004287 FAD binding motif [chemical binding]; other site 717785004288 phosphate binding motif [ion binding]; other site 717785004289 beta-alpha-beta structure motif; other site 717785004290 NAD binding pocket [chemical binding]; other site 717785004291 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 717785004292 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 717785004293 K+-transporting ATPase, c chain; Region: KdpC; cl00944 717785004294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004295 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004298 active site 717785004299 phosphorylation site [posttranslational modification] 717785004300 intermolecular recognition site; other site 717785004301 dimerization interface [polypeptide binding]; other site 717785004302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004303 DNA binding site [nucleotide binding] 717785004304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004306 ATP binding site [chemical binding]; other site 717785004307 Mg2+ binding site [ion binding]; other site 717785004308 G-X-G motif; other site 717785004309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004310 DNA binding site [nucleotide binding] 717785004311 Predicted integral membrane protein [Function unknown]; Region: COG5616 717785004312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785004313 binding surface 717785004314 TPR motif; other site 717785004315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785004316 binding surface 717785004317 TPR motif; other site 717785004318 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 717785004319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004320 NAD(P) binding site [chemical binding]; other site 717785004321 active site 717785004322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785004323 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 717785004324 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 717785004325 Substrate binding site; other site 717785004326 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 717785004327 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717785004328 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 717785004329 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 717785004330 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717785004331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785004332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785004333 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 717785004334 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 717785004335 AAA domain; Region: AAA_31; pfam13614 717785004336 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 717785004337 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 717785004338 Bacterial sugar transferase; Region: Bac_transf; pfam02397 717785004339 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785004340 SLBB domain; Region: SLBB; pfam10531 717785004341 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785004342 Chain length determinant protein; Region: Wzz; cl15801 717785004343 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 717785004344 AAA domain; Region: AAA_31; pfam13614 717785004345 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 717785004346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785004347 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 717785004348 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 717785004349 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785004350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785004351 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 717785004352 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785004353 N-terminal plug; other site 717785004354 ligand-binding site [chemical binding]; other site 717785004355 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785004356 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 717785004357 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 717785004358 Protein of unknown function, DUF417; Region: DUF417; cl01162 717785004359 Cupin; Region: Cupin_6; pfam12852 717785004360 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 717785004361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004363 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 717785004364 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : enzyme 717785004365 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 717785004366 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : enzyme 717785004367 HAMP domain; Region: HAMP; pfam00672 717785004368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 717785004369 dimer interface [polypeptide binding]; other site 717785004370 phosphorylation site [posttranslational modification] 717785004371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004372 ATP binding site [chemical binding]; other site 717785004373 G-X-G motif; other site 717785004374 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785004375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004376 active site 717785004377 phosphorylation site [posttranslational modification] 717785004378 intermolecular recognition site; other site 717785004379 dimerization interface [polypeptide binding]; other site 717785004380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004381 DNA binding site [nucleotide binding] 717785004382 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 717785004383 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 717785004384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004385 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004386 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785004387 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 717785004388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785004389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004390 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004391 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 717785004392 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785004393 Walker A/P-loop; other site 717785004394 ATP binding site [chemical binding]; other site 717785004395 Q-loop/lid; other site 717785004396 ABC transporter signature motif; other site 717785004397 Walker B; other site 717785004398 D-loop; other site 717785004399 H-loop/switch region; other site 717785004400 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785004401 FtsX-like permease family; Region: FtsX; pfam02687 717785004402 AAA domain; Region: AAA_17; pfam13207 717785004403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 717785004404 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785004405 Uncharacterized conserved protein [Function unknown]; Region: COG1432 717785004406 LabA_like proteins; Region: LabA; cd10911 717785004407 putative metal binding site [ion binding]; other site 717785004408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004409 HAMP domain; Region: HAMP; pfam00672 717785004410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004411 ATP binding site [chemical binding]; other site 717785004412 Mg2+ binding site [ion binding]; other site 717785004413 G-X-G motif; other site 717785004414 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785004415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004416 active site 717785004417 phosphorylation site [posttranslational modification] 717785004418 intermolecular recognition site; other site 717785004419 dimerization interface [polypeptide binding]; other site 717785004420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004421 DNA binding site [nucleotide binding] 717785004422 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 717785004423 putative active site [active] 717785004424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 717785004425 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785004426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 717785004427 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 717785004428 active site 717785004429 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785004430 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785004431 putative metal binding site; other site 717785004432 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 717785004433 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 717785004434 substrate binding site; other site 717785004435 tetramer interface; other site 717785004436 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 717785004437 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 717785004438 NADP binding site [chemical binding]; other site 717785004439 active site 717785004440 putative substrate binding site [chemical binding]; other site 717785004441 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 717785004442 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 717785004443 NAD binding site [chemical binding]; other site 717785004444 substrate binding site [chemical binding]; other site 717785004445 homodimer interface [polypeptide binding]; other site 717785004446 active site 717785004447 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 717785004448 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 717785004449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785004450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785004451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785004452 Walker A/P-loop; other site 717785004453 ATP binding site [chemical binding]; other site 717785004454 Q-loop/lid; other site 717785004455 ABC transporter signature motif; other site 717785004456 Walker B; other site 717785004457 D-loop; other site 717785004458 H-loop/switch region; other site 717785004459 Methyltransferase domain; Region: Methyltransf_24; pfam13578 717785004460 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 717785004461 sulfotransferase; Region: PLN02164 717785004462 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 717785004463 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 717785004464 substrate binding site; other site 717785004465 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 717785004466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004467 NAD(P) binding site [chemical binding]; other site 717785004468 active site 717785004469 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 717785004470 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785004471 Methyltransferase domain; Region: Methyltransf_12; pfam08242 717785004472 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 717785004473 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 717785004474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785004475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004476 NAD(P) binding site [chemical binding]; other site 717785004477 active site 717785004478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004479 active site 717785004480 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717785004481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004482 active site 717785004483 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 717785004484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785004485 active site 717785004486 Integrase core domain; Region: rve_3; pfam13683 717785004487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785004488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785004490 active site 717785004491 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785004492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004493 active site 717785004494 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 717785004495 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 717785004496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785004497 FeS/SAM binding site; other site 717785004498 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 717785004499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785004500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004501 non-specific DNA binding site [nucleotide binding]; other site 717785004502 salt bridge; other site 717785004503 sequence-specific DNA binding site [nucleotide binding]; other site 717785004504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004505 non-specific DNA binding site [nucleotide binding]; other site 717785004506 salt bridge; other site 717785004507 sequence-specific DNA binding site [nucleotide binding]; other site 717785004508 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 717785004509 Protein of unknown function (DUF968); Region: DUF968; pfam06147 717785004510 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 717785004511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785004512 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785004513 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 717785004514 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 717785004515 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 717785004516 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785004517 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785004518 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785004519 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 717785004520 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 717785004521 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 717785004522 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785004523 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 717785004524 putative active site [active] 717785004525 putative FMN binding site [chemical binding]; other site 717785004526 putative substrate binding site [chemical binding]; other site 717785004527 putative catalytic residue [active] 717785004528 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 717785004529 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 717785004530 Cysteine-rich domain; Region: CCG; pfam02754 717785004531 Cysteine-rich domain; Region: CCG; pfam02754 717785004532 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 717785004533 Electron transfer flavoprotein domain; Region: ETF; smart00893 717785004534 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785004535 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 717785004536 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785004537 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785004538 [2Fe-2S] cluster binding site [ion binding]; other site 717785004539 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 717785004540 putative alpha subunit interface [polypeptide binding]; other site 717785004541 putative active site [active] 717785004542 putative substrate binding site [chemical binding]; other site 717785004543 Fe binding site [ion binding]; other site 717785004544 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785004545 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 717785004546 FAD binding pocket [chemical binding]; other site 717785004547 FAD binding motif [chemical binding]; other site 717785004548 phosphate binding motif [ion binding]; other site 717785004549 beta-alpha-beta structure motif; other site 717785004550 NAD binding pocket [chemical binding]; other site 717785004551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785004552 catalytic loop [active] 717785004553 iron binding site [ion binding]; other site 717785004554 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 717785004555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785004556 Walker A/P-loop; other site 717785004557 ATP binding site [chemical binding]; other site 717785004558 Q-loop/lid; other site 717785004559 ABC transporter signature motif; other site 717785004560 Walker B; other site 717785004561 D-loop; other site 717785004562 H-loop/switch region; other site 717785004563 CBS domain; Region: CBS; pfam00571 717785004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785004565 dimer interface [polypeptide binding]; other site 717785004566 conserved gate region; other site 717785004567 putative PBP binding loops; other site 717785004568 ABC-ATPase subunit interface; other site 717785004569 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 717785004570 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 717785004571 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785004572 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 717785004573 conserved cys residue [active] 717785004574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004575 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 717785004576 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 717785004577 tetrameric interface [polypeptide binding]; other site 717785004578 NAD binding site [chemical binding]; other site 717785004579 catalytic residues [active] 717785004580 choline dehydrogenase; Validated; Region: PRK02106 717785004581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785004582 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785004583 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785004584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004585 putative substrate translocation pore; other site 717785004586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004587 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785004588 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785004589 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785004590 hypothetical protein; Provisional; Region: PRK12472 717785004591 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785004592 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 717785004593 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 717785004594 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 717785004595 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 717785004596 domain_subunit interface; other site 717785004597 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 717785004598 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 717785004599 FTR, proximal lobe; Region: FTR_C; pfam02741 717785004600 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 717785004601 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 717785004602 active site 717785004603 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 717785004604 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 717785004605 putative [4Fe-4S] binding site [ion binding]; other site 717785004606 putative molybdopterin cofactor binding site [chemical binding]; other site 717785004607 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785004608 putative hydrophobic ligand binding site [chemical binding]; other site 717785004609 protein interface [polypeptide binding]; other site 717785004610 gate; other site 717785004611 Uncharacterized conserved protein [Function unknown]; Region: COG3391 717785004612 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004613 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004614 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785004616 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785004617 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 717785004618 Trp docking motif [polypeptide binding]; other site 717785004619 dimer interface [polypeptide binding]; other site 717785004620 active site 717785004621 small subunit binding site [polypeptide binding]; other site 717785004622 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 717785004623 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785004624 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 717785004625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785004626 substrate binding pocket [chemical binding]; other site 717785004627 membrane-bound complex binding site; other site 717785004628 hinge residues; other site 717785004629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 717785004630 active site residue [active] 717785004631 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 717785004632 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 717785004633 TrkA-N domain; Region: TrkA_N; pfam02254 717785004634 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 717785004635 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 717785004636 TPP-binding site [chemical binding]; other site 717785004637 dimer interface [polypeptide binding]; other site 717785004638 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785004639 PYR/PP interface [polypeptide binding]; other site 717785004640 dimer interface [polypeptide binding]; other site 717785004641 TPP binding site [chemical binding]; other site 717785004642 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785004643 Phosphoglycerate kinase; Region: PGK; pfam00162 717785004644 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 717785004645 substrate binding site [chemical binding]; other site 717785004646 hinge regions; other site 717785004647 ADP binding site [chemical binding]; other site 717785004648 catalytic site [active] 717785004649 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 717785004650 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 717785004651 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 717785004652 dimer interface [polypeptide binding]; other site 717785004653 substrate binding site [chemical binding]; other site 717785004654 ATP binding site [chemical binding]; other site 717785004655 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 717785004656 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 717785004657 MFS_1 like family; Region: MFS_1_like; pfam12832 717785004658 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 717785004659 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 717785004660 active site 717785004661 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785004662 putative binding surface; other site 717785004663 active site 717785004664 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 717785004665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785004666 catalytic loop [active] 717785004667 iron binding site [ion binding]; other site 717785004668 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 717785004669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785004670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785004671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 717785004672 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785004673 Gram-negative porin; Region: Porin_4; pfam13609 717785004674 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 717785004675 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 717785004676 glucosyltransferase MdoH; Provisional; Region: PRK05454 717785004677 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717785004678 active site 717785004679 hypothetical protein; Provisional; Region: PRK05415 717785004680 Domain of unknown function (DUF697); Region: DUF697; cl12064 717785004681 YcjX-like family, DUF463; Region: DUF463; pfam04317 717785004682 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 717785004683 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 717785004684 Predicted metalloprotease [General function prediction only]; Region: COG2321 717785004685 Sporulation related domain; Region: SPOR; cl10051 717785004686 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 717785004687 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 717785004688 Substrate binding site; other site 717785004689 Mg++ binding site; other site 717785004690 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 717785004691 active site 717785004692 substrate binding site [chemical binding]; other site 717785004693 CoA binding site [chemical binding]; other site 717785004694 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 717785004695 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 717785004696 glutaminase active site [active] 717785004697 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 717785004698 dimer interface [polypeptide binding]; other site 717785004699 active site 717785004700 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 717785004701 dimer interface [polypeptide binding]; other site 717785004702 active site 717785004703 TPR repeat; Region: TPR_11; pfam13414 717785004704 Sporulation related domain; Region: SPOR; pfam05036 717785004705 Uncharacterized conserved protein [Function unknown]; Region: COG2928 717785004706 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 717785004707 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 717785004708 generic binding surface II; other site 717785004709 ssDNA binding site; other site 717785004710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785004711 ATP binding site [chemical binding]; other site 717785004712 putative Mg++ binding site [ion binding]; other site 717785004713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785004714 nucleotide binding region [chemical binding]; other site 717785004715 ATP-binding site [chemical binding]; other site 717785004716 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 717785004717 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 717785004718 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 717785004719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785004720 ATP binding site [chemical binding]; other site 717785004721 putative Mg++ binding site [ion binding]; other site 717785004722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785004723 nucleotide binding region [chemical binding]; other site 717785004724 ATP-binding site [chemical binding]; other site 717785004725 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 717785004726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785004727 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785004728 acyl-activating enzyme (AAE) consensus motif; other site 717785004729 AMP binding site [chemical binding]; other site 717785004730 active site 717785004731 CoA binding site [chemical binding]; other site 717785004732 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785004733 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785004734 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 717785004735 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 717785004736 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 717785004737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785004738 Coenzyme A binding pocket [chemical binding]; other site 717785004739 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 717785004740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785004741 active site 717785004742 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 717785004743 Protein of unknown function, DUF486; Region: DUF486; cl01236 717785004744 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 717785004745 oligomer interface [polypeptide binding]; other site 717785004746 putative active site [active] 717785004747 Mn binding site [ion binding]; other site 717785004748 Putative ParB-like nuclease; Region: ParBc_2; cl17538 717785004749 ssDNA binding protein; Region: Viral_DNA_bp; cl17757 717785004750 Protein of unknown function (DUF992); Region: DUF992; pfam06186 717785004751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 717785004752 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 717785004753 Pirin-related protein [General function prediction only]; Region: COG1741 717785004754 Pirin; Region: Pirin; pfam02678 717785004755 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 717785004756 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 717785004757 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 717785004758 active site 717785004759 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 717785004760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785004761 FeS/SAM binding site; other site 717785004762 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 717785004763 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717785004764 CoenzymeA binding site [chemical binding]; other site 717785004765 subunit interaction site [polypeptide binding]; other site 717785004766 PHB binding site; other site 717785004767 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 717785004768 Ligand Binding Site [chemical binding]; other site 717785004769 Uncharacterized conserved protein [Function unknown]; Region: COG3791 717785004770 enolase; Provisional; Region: eno; PRK00077 717785004771 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 717785004772 dimer interface [polypeptide binding]; other site 717785004773 metal binding site [ion binding]; metal-binding site 717785004774 substrate binding pocket [chemical binding]; other site 717785004775 short chain dehydrogenase; Provisional; Region: PRK06701 717785004776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004777 NAD(P) binding site [chemical binding]; other site 717785004778 active site 717785004779 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785004780 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785004781 P-loop; other site 717785004782 Magnesium ion binding site [ion binding]; other site 717785004783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785004784 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 717785004785 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 717785004786 catalytic triad [active] 717785004787 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 717785004788 ligand-binding site [chemical binding]; other site 717785004789 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 717785004790 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785004791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004792 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 717785004793 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 717785004794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785004795 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 717785004796 putative active site [active] 717785004797 heme pocket [chemical binding]; other site 717785004798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785004799 putative active site [active] 717785004800 heme pocket [chemical binding]; other site 717785004801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785004802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785004803 metal binding site [ion binding]; metal-binding site 717785004804 active site 717785004805 I-site; other site 717785004806 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 717785004807 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 717785004808 active site 717785004809 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785004810 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785004811 active site 717785004812 catalytic tetrad [active] 717785004813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785004814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785004815 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785004816 putative effector binding pocket; other site 717785004817 putative dimerization interface [polypeptide binding]; other site 717785004818 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 717785004819 Domain of unknown function DUF20; Region: UPF0118; pfam01594 717785004820 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 717785004821 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785004822 CsbD-like; Region: CsbD; cl17424 717785004823 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 717785004824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 717785004825 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 717785004826 Predicted membrane protein [Function unknown]; Region: COG3212 717785004827 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 717785004828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004830 active site 717785004831 phosphorylation site [posttranslational modification] 717785004832 intermolecular recognition site; other site 717785004833 dimerization interface [polypeptide binding]; other site 717785004834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004835 DNA binding site [nucleotide binding] 717785004836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004838 ATP binding site [chemical binding]; other site 717785004839 Mg2+ binding site [ion binding]; other site 717785004840 G-X-G motif; other site 717785004841 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 717785004842 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004843 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004844 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004845 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004846 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785004847 active site 717785004848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004849 HAMP domain; Region: HAMP; pfam00672 717785004850 dimerization interface [polypeptide binding]; other site 717785004851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785004852 dimer interface [polypeptide binding]; other site 717785004853 phosphorylation site [posttranslational modification] 717785004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004855 ATP binding site [chemical binding]; other site 717785004856 Mg2+ binding site [ion binding]; other site 717785004857 G-X-G motif; other site 717785004858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785004860 active site 717785004861 phosphorylation site [posttranslational modification] 717785004862 intermolecular recognition site; other site 717785004863 dimerization interface [polypeptide binding]; other site 717785004864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785004865 DNA binding site [nucleotide binding] 717785004866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785004868 putative substrate translocation pore; other site 717785004869 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 717785004870 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 717785004871 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 717785004872 dimer interface [polypeptide binding]; other site 717785004873 ssDNA binding site [nucleotide binding]; other site 717785004874 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785004875 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 717785004876 nucleotide binding site [chemical binding]; other site 717785004877 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 717785004878 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 717785004879 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785004880 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 717785004881 active site 717785004882 Int/Topo IB signature motif; other site 717785004883 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785004884 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 717785004885 Sporulation related domain; Region: SPOR; pfam05036 717785004886 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 717785004887 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 717785004888 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 717785004889 thymidylate kinase; Validated; Region: tmk; PRK00698 717785004890 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 717785004891 TMP-binding site; other site 717785004892 ATP-binding site [chemical binding]; other site 717785004893 DNA polymerase III subunit delta'; Validated; Region: PRK07471 717785004894 DNA polymerase III subunit delta'; Validated; Region: PRK08485 717785004895 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 717785004896 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 717785004897 active site 717785004898 HIGH motif; other site 717785004899 KMSKS motif; other site 717785004900 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 717785004901 anticodon binding site; other site 717785004902 tRNA binding surface [nucleotide binding]; other site 717785004903 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 717785004904 active site 717785004905 putative hydrolase; Provisional; Region: PRK02113 717785004906 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 717785004907 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 717785004908 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 717785004909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004910 NAD(P) binding site [chemical binding]; other site 717785004911 active site 717785004912 amidophosphoribosyltransferase; Provisional; Region: PRK09123 717785004913 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 717785004914 active site 717785004915 tetramer interface [polypeptide binding]; other site 717785004916 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785004917 active site 717785004918 Colicin V production protein; Region: Colicin_V; pfam02674 717785004919 DNA repair protein RadA; Provisional; Region: PRK11823 717785004920 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 717785004921 Walker A motif/ATP binding site; other site 717785004922 ATP binding site [chemical binding]; other site 717785004923 Walker B motif; other site 717785004924 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 717785004925 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 717785004926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 717785004927 active site 717785004928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785004929 dimer interface [polypeptide binding]; other site 717785004930 substrate binding site [chemical binding]; other site 717785004931 catalytic residues [active] 717785004932 replicative DNA helicase; Provisional; Region: PRK09165 717785004933 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 717785004934 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 717785004935 Walker A motif; other site 717785004936 ATP binding site [chemical binding]; other site 717785004937 Walker B motif; other site 717785004938 DNA binding loops [nucleotide binding] 717785004939 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 717785004940 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 717785004941 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 717785004942 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 717785004943 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 717785004944 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 717785004945 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 717785004946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785004947 putative metal binding site [ion binding]; other site 717785004948 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 717785004949 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 717785004950 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 717785004951 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 717785004952 homotetramer interface [polypeptide binding]; other site 717785004953 NAD(P) binding site [chemical binding]; other site 717785004954 homodimer interface [polypeptide binding]; other site 717785004955 active site 717785004956 acyl carrier protein; Provisional; Region: acpP; PRK00982 717785004957 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 717785004958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785004959 dimer interface [polypeptide binding]; other site 717785004960 active site 717785004961 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 717785004962 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 717785004963 dimerization interface [polypeptide binding]; other site 717785004964 hypothetical protein; Provisional; Region: PRK11820 717785004965 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 717785004966 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 717785004967 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 717785004968 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 717785004969 catalytic site [active] 717785004970 G-X2-G-X-G-K; other site 717785004971 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 717785004972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785004973 S-adenosylmethionine binding site [chemical binding]; other site 717785004974 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 717785004975 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 717785004976 SurA N-terminal domain; Region: SurA_N; pfam09312 717785004977 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 717785004978 Organic solvent tolerance protein; Region: OstA_C; pfam04453 717785004979 Predicted permeases [General function prediction only]; Region: COG0795 717785004980 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 717785004981 Predicted permeases [General function prediction only]; Region: COG0795 717785004982 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 717785004983 multifunctional aminopeptidase A; Provisional; Region: PRK00913 717785004984 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 717785004985 interface (dimer of trimers) [polypeptide binding]; other site 717785004986 Substrate-binding/catalytic site; other site 717785004987 Zn-binding sites [ion binding]; other site 717785004988 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 717785004989 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 717785004990 homodimer interface [polypeptide binding]; other site 717785004991 metal binding site [ion binding]; metal-binding site 717785004992 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 717785004993 homodimer interface [polypeptide binding]; other site 717785004994 active site 717785004995 putative chemical substrate binding site [chemical binding]; other site 717785004996 metal binding site [ion binding]; metal-binding site 717785004997 hypothetical protein; Provisional; Region: PRK06185 717785004998 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785004999 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785005000 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 717785005001 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 717785005002 HflX GTPase family; Region: HflX; cd01878 717785005003 G1 box; other site 717785005004 GTP/Mg2+ binding site [chemical binding]; other site 717785005005 Switch I region; other site 717785005006 G2 box; other site 717785005007 G3 box; other site 717785005008 Switch II region; other site 717785005009 G4 box; other site 717785005010 G5 box; other site 717785005011 bacterial Hfq-like; Region: Hfq; cd01716 717785005012 hexamer interface [polypeptide binding]; other site 717785005013 Sm1 motif; other site 717785005014 RNA binding site [nucleotide binding]; other site 717785005015 Sm2 motif; other site 717785005016 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 717785005017 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 717785005018 homodimer interface [polypeptide binding]; other site 717785005019 substrate-cofactor binding pocket; other site 717785005020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005021 catalytic residue [active] 717785005022 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785005023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785005024 active site 717785005025 phosphorylation site [posttranslational modification] 717785005026 intermolecular recognition site; other site 717785005027 dimerization interface [polypeptide binding]; other site 717785005028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785005029 Walker A motif; other site 717785005030 ATP binding site [chemical binding]; other site 717785005031 Walker B motif; other site 717785005032 arginine finger; other site 717785005033 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785005034 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 717785005035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785005036 dimerization interface [polypeptide binding]; other site 717785005037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785005038 putative active site [active] 717785005039 heme pocket [chemical binding]; other site 717785005040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785005041 dimer interface [polypeptide binding]; other site 717785005042 phosphorylation site [posttranslational modification] 717785005043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005044 ATP binding site [chemical binding]; other site 717785005045 Mg2+ binding site [ion binding]; other site 717785005046 G-X-G motif; other site 717785005047 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 717785005048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785005049 active site 717785005050 phosphorylation site [posttranslational modification] 717785005051 intermolecular recognition site; other site 717785005052 dimerization interface [polypeptide binding]; other site 717785005053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785005054 Walker A motif; other site 717785005055 ATP binding site [chemical binding]; other site 717785005056 Walker B motif; other site 717785005057 arginine finger; other site 717785005058 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 717785005059 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785005060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785005061 dimer interface [polypeptide binding]; other site 717785005062 phosphorylation site [posttranslational modification] 717785005063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005064 ATP binding site [chemical binding]; other site 717785005065 Mg2+ binding site [ion binding]; other site 717785005066 G-X-G motif; other site 717785005067 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 717785005068 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 717785005069 FMN binding site [chemical binding]; other site 717785005070 active site 717785005071 catalytic residues [active] 717785005072 substrate binding site [chemical binding]; other site 717785005073 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 717785005074 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 717785005075 substrate binding site; other site 717785005076 dimer interface; other site 717785005077 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 717785005078 homotrimer interaction site [polypeptide binding]; other site 717785005079 zinc binding site [ion binding]; other site 717785005080 CDP-binding sites; other site 717785005081 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 717785005082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785005083 MarR family; Region: MarR_2; pfam12802 717785005084 Competence-damaged protein; Region: CinA; pfam02464 717785005085 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 717785005086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005088 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 717785005089 putative coenzyme Q binding site [chemical binding]; other site 717785005090 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 717785005091 Septum formation initiator; Region: DivIC; pfam04977 717785005092 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785005093 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 717785005094 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785005095 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 717785005096 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 717785005097 putative acyl-acceptor binding pocket; other site 717785005098 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 717785005099 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 717785005100 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 717785005101 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 717785005102 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 717785005103 active site 717785005104 dimer interface [polypeptide binding]; other site 717785005105 motif 1; other site 717785005106 motif 2; other site 717785005107 motif 3; other site 717785005108 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 717785005109 anticodon binding site; other site 717785005110 hypothetical protein; Validated; Region: PRK00041 717785005111 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717785005112 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 717785005113 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 717785005114 trimerization site [polypeptide binding]; other site 717785005115 active site 717785005116 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 717785005117 hypothetical protein; Provisional; Region: PRK10279 717785005118 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785005119 nucleophile elbow; other site 717785005120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 717785005121 FOG: CBS domain [General function prediction only]; Region: COG0517 717785005122 Rhomboid family; Region: Rhomboid; cl11446 717785005123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 717785005124 PAS domain; Region: PAS_5; pfam07310 717785005125 PilZ domain; Region: PilZ; pfam07238 717785005126 PilZ domain; Region: PilZ; pfam07238 717785005127 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 717785005128 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 717785005129 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 717785005130 trimer interface [polypeptide binding]; other site 717785005131 putative metal binding site [ion binding]; other site 717785005132 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 717785005133 serine acetyltransferase; Provisional; Region: cysE; PRK11132 717785005134 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 717785005135 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 717785005136 trimer interface [polypeptide binding]; other site 717785005137 active site 717785005138 substrate binding site [chemical binding]; other site 717785005139 CoA binding site [chemical binding]; other site 717785005140 enoyl-CoA hydratase; Provisional; Region: PRK06127 717785005141 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785005142 substrate binding site [chemical binding]; other site 717785005143 oxyanion hole (OAH) forming residues; other site 717785005144 trimer interface [polypeptide binding]; other site 717785005145 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785005146 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 717785005147 NodB motif; other site 717785005148 putative active site [active] 717785005149 putative catalytic site [active] 717785005150 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 717785005151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785005152 Coenzyme A binding pocket [chemical binding]; other site 717785005153 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7992050; Product type e : enzyme 717785005154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785005155 S-adenosylmethionine binding site [chemical binding]; other site 717785005156 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 717785005157 FAD binding site [chemical binding]; other site 717785005158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785005159 putative DNA binding site [nucleotide binding]; other site 717785005160 putative Zn2+ binding site [ion binding]; other site 717785005161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785005162 S-adenosylmethionine binding site [chemical binding]; other site 717785005163 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 717785005164 PRC-barrel domain; Region: PRC; pfam05239 717785005165 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 717785005166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785005167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785005168 ABC transporter; Region: ABC_tran_2; pfam12848 717785005169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785005170 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 717785005171 CAAX protease self-immunity; Region: Abi; pfam02517 717785005172 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 717785005173 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 717785005174 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785005175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785005176 dimerization interface [polypeptide binding]; other site 717785005177 putative DNA binding site [nucleotide binding]; other site 717785005178 putative Zn2+ binding site [ion binding]; other site 717785005179 AsnC family; Region: AsnC_trans_reg; pfam01037 717785005180 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 717785005181 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 717785005182 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 717785005183 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 717785005184 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785005185 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 717785005186 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 717785005187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785005188 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785005189 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 717785005190 IMP binding site; other site 717785005191 dimer interface [polypeptide binding]; other site 717785005192 interdomain contacts; other site 717785005193 partial ornithine binding site; other site 717785005194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785005195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785005196 putative substrate translocation pore; other site 717785005197 Protein of unknown function, DUF399; Region: DUF399; cl01139 717785005198 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 717785005199 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 717785005200 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 717785005201 catalytic site [active] 717785005202 subunit interface [polypeptide binding]; other site 717785005203 Yqey-like protein; Region: YqeY; pfam09424 717785005204 DNA primase; Validated; Region: dnaG; PRK05667 717785005205 CHC2 zinc finger; Region: zf-CHC2; pfam01807 717785005206 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 717785005207 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 717785005208 active site 717785005209 metal binding site [ion binding]; metal-binding site 717785005210 interdomain interaction site; other site 717785005211 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 717785005212 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 717785005213 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 717785005214 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 717785005215 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 717785005216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785005217 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717785005218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785005219 DNA binding residues [nucleotide binding] 717785005220 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 717785005221 putative dimer interface [polypeptide binding]; other site 717785005222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785005223 transcription elongation factor regulatory protein; Validated; Region: PRK06342 717785005224 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 717785005225 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 717785005226 Uncharacterized conserved protein [Function unknown]; Region: COG2128 717785005227 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 717785005228 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 717785005229 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 717785005230 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785005231 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 717785005232 putative active site [active] 717785005233 catalytic triad [active] 717785005234 putative dimer interface [polypeptide binding]; other site 717785005235 Uncharacterized conserved protein [Function unknown]; Region: COG2968 717785005236 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 717785005237 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 717785005238 active site 717785005239 catalytic residues [active] 717785005240 DNA binding site [nucleotide binding] 717785005241 Int/Topo IB signature motif; other site 717785005242 Phage-related protein [Function unknown]; Region: COG4695; cl01923 717785005243 Phage portal protein; Region: Phage_portal; pfam04860 717785005244 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 717785005245 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 717785005246 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 717785005247 Phage capsid family; Region: Phage_capsid; pfam05065 717785005248 Putative Ig domain; Region: He_PIG; pfam05345 717785005249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785005250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785005251 non-specific DNA binding site [nucleotide binding]; other site 717785005252 salt bridge; other site 717785005253 sequence-specific DNA binding site [nucleotide binding]; other site 717785005254 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 717785005255 active site 717785005256 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785005257 oligomerization interface [polypeptide binding]; other site 717785005258 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 717785005259 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 717785005260 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 717785005261 Phage Terminase; Region: Terminase_1; pfam03354 717785005262 tape measure domain; Region: tape_meas_nterm; TIGR02675 717785005263 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 717785005264 T5orf172 domain; Region: T5orf172; pfam10544 717785005265 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 717785005266 Cytochrome c [Energy production and conversion]; Region: COG3258 717785005267 Cytochrome c; Region: Cytochrom_C; pfam00034 717785005268 DsrE/DsrF-like family; Region: DrsE; pfam02635 717785005269 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 717785005270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785005271 Autotransporter beta-domain; Region: Autotransporter; pfam03797 717785005272 H+ Antiporter protein; Region: 2A0121; TIGR00900 717785005273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785005274 putative substrate translocation pore; other site 717785005275 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 717785005276 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 717785005277 phosphate binding site [ion binding]; other site 717785005278 Cyclophilin-like; Region: Cyclophil_like; cl17583 717785005279 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 717785005280 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785005281 dimer interface [polypeptide binding]; other site 717785005282 active site 717785005283 acyl carrier protein; Provisional; Region: acpP; PRK00982 717785005284 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785005285 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 717785005286 acyl-activating enzyme (AAE) consensus motif; other site 717785005287 putative AMP binding site [chemical binding]; other site 717785005288 putative active site [active] 717785005289 putative CoA binding site [chemical binding]; other site 717785005290 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 717785005291 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 717785005292 DNA binding residues [nucleotide binding] 717785005293 putative dimer interface [polypeptide binding]; other site 717785005294 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 717785005295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785005296 S-adenosylmethionine binding site [chemical binding]; other site 717785005297 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 717785005298 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785005299 dimer interface [polypeptide binding]; other site 717785005300 active site 717785005301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785005302 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 717785005303 substrate binding site [chemical binding]; other site 717785005304 oxyanion hole (OAH) forming residues; other site 717785005305 trimer interface [polypeptide binding]; other site 717785005306 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 717785005307 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 717785005308 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 717785005309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785005310 active site 717785005311 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 717785005312 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 717785005313 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 717785005314 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 717785005315 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 717785005316 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 717785005317 BNR repeat-like domain; Region: BNR_2; pfam13088 717785005318 methionine gamma-lyase; Validated; Region: PRK07049 717785005319 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785005320 homodimer interface [polypeptide binding]; other site 717785005321 substrate-cofactor binding pocket; other site 717785005322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005323 catalytic residue [active] 717785005324 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 717785005325 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 717785005326 active site 717785005327 catalytic residues [active] 717785005328 metal binding site [ion binding]; metal-binding site 717785005329 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 717785005330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717785005331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785005332 Coenzyme A binding pocket [chemical binding]; other site 717785005333 SnoaL-like domain; Region: SnoaL_3; pfam13474 717785005334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785005335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785005336 salt bridge; other site 717785005337 non-specific DNA binding site [nucleotide binding]; other site 717785005338 sequence-specific DNA binding site [nucleotide binding]; other site 717785005339 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 717785005340 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785005341 putative NAD(P) binding site [chemical binding]; other site 717785005342 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 717785005343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717785005344 active site 717785005345 HIGH motif; other site 717785005346 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717785005347 KMSKS motif; other site 717785005348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 717785005349 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 717785005350 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 717785005351 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785005352 HIGH motif; other site 717785005353 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785005354 active site 717785005355 KMSKS motif; other site 717785005356 NAD synthetase; Provisional; Region: PRK13981 717785005357 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 717785005358 multimer interface [polypeptide binding]; other site 717785005359 active site 717785005360 catalytic triad [active] 717785005361 protein interface 1 [polypeptide binding]; other site 717785005362 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 717785005363 homodimer interface [polypeptide binding]; other site 717785005364 NAD binding pocket [chemical binding]; other site 717785005365 ATP binding pocket [chemical binding]; other site 717785005366 Mg binding site [ion binding]; other site 717785005367 active-site loop [active] 717785005368 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 717785005369 short chain dehydrogenase; Provisional; Region: PRK07063 717785005370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005371 NAD(P) binding site [chemical binding]; other site 717785005372 active site 717785005373 glutathione reductase; Validated; Region: PRK06116 717785005374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785005375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785005376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785005377 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 717785005378 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 717785005379 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785005380 active site 717785005381 dimer interface [polypeptide binding]; other site 717785005382 phosphoglycolate phosphatase; Provisional; Region: PRK13222 717785005383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785005384 motif II; other site 717785005385 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 717785005386 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 717785005387 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 717785005388 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 717785005389 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785005390 active site 717785005391 DNA binding site [nucleotide binding] 717785005392 Int/Topo IB signature motif; other site 717785005393 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785005394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785005395 non-specific DNA binding site [nucleotide binding]; other site 717785005396 salt bridge; other site 717785005397 sequence-specific DNA binding site [nucleotide binding]; other site 717785005398 Cupin domain; Region: Cupin_2; pfam07883 717785005399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785005400 classical (c) SDRs; Region: SDR_c; cd05233 717785005401 NAD(P) binding site [chemical binding]; other site 717785005402 active site 717785005403 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785005404 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785005405 Walker A/P-loop; other site 717785005406 ATP binding site [chemical binding]; other site 717785005407 Q-loop/lid; other site 717785005408 ABC transporter signature motif; other site 717785005409 Walker B; other site 717785005410 D-loop; other site 717785005411 H-loop/switch region; other site 717785005412 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785005413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785005414 dimer interface [polypeptide binding]; other site 717785005415 conserved gate region; other site 717785005416 putative PBP binding loops; other site 717785005417 ABC-ATPase subunit interface; other site 717785005418 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785005419 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 717785005420 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 717785005421 metal binding site [ion binding]; metal-binding site 717785005422 dimer interface [polypeptide binding]; other site 717785005423 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785005424 metal binding site 2 [ion binding]; metal-binding site 717785005425 putative DNA binding helix; other site 717785005426 metal binding site 1 [ion binding]; metal-binding site 717785005427 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 717785005428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785005429 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 717785005430 lipoyl attachment site [posttranslational modification]; other site 717785005431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785005432 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785005433 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 717785005434 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 717785005435 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 717785005436 active site 717785005437 catalytic site [active] 717785005438 Zn binding site [ion binding]; other site 717785005439 tetramer interface [polypeptide binding]; other site 717785005440 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 717785005441 homotrimer interaction site [polypeptide binding]; other site 717785005442 putative active site [active] 717785005443 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785005444 homotrimer interaction site [polypeptide binding]; other site 717785005445 putative active site [active] 717785005446 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 717785005447 homotrimer interaction site [polypeptide binding]; other site 717785005448 putative active site [active] 717785005449 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 717785005450 dimerization interface [polypeptide binding]; other site 717785005451 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 717785005452 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 717785005453 [2Fe-2S] cluster binding site [ion binding]; other site 717785005454 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 717785005455 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 717785005456 dinuclear metal binding motif [ion binding]; other site 717785005457 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785005458 putative hydrophobic ligand binding site [chemical binding]; other site 717785005459 protein interface [polypeptide binding]; other site 717785005460 gate; other site 717785005461 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 717785005462 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 717785005463 active site 717785005464 catalytic site [active] 717785005465 Zn binding site [ion binding]; other site 717785005466 tetramer interface [polypeptide binding]; other site 717785005467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005468 short chain dehydrogenase; Validated; Region: PRK07069 717785005469 NAD(P) binding site [chemical binding]; other site 717785005470 active site 717785005471 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785005472 classical (c) SDRs; Region: SDR_c; cd05233 717785005473 NAD(P) binding site [chemical binding]; other site 717785005474 active site 717785005475 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785005476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785005477 dimer interface [polypeptide binding]; other site 717785005478 conserved gate region; other site 717785005479 putative PBP binding loops; other site 717785005480 ABC-ATPase subunit interface; other site 717785005481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785005482 dimer interface [polypeptide binding]; other site 717785005483 conserved gate region; other site 717785005484 putative PBP binding loops; other site 717785005485 ABC-ATPase subunit interface; other site 717785005486 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785005487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785005488 Walker A/P-loop; other site 717785005489 ATP binding site [chemical binding]; other site 717785005490 Q-loop/lid; other site 717785005491 ABC transporter signature motif; other site 717785005492 Walker B; other site 717785005493 D-loop; other site 717785005494 H-loop/switch region; other site 717785005495 TOBE domain; Region: TOBE_2; pfam08402 717785005496 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717785005497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785005498 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 717785005499 Amidinotransferase; Region: Amidinotransf; pfam02274 717785005500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785005501 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785005502 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 717785005503 dimerization interface [polypeptide binding]; other site 717785005504 substrate binding pocket [chemical binding]; other site 717785005505 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 717785005506 DNA binding residues [nucleotide binding] 717785005507 dimerization interface [polypeptide binding]; other site 717785005508 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 717785005509 active site 717785005510 catalytic residues [active] 717785005511 DNA binding site [nucleotide binding] 717785005512 Int/Topo IB signature motif; other site 717785005513 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785005514 HPP family; Region: HPP; pfam04982 717785005515 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 717785005516 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 717785005517 putative ion selectivity filter; other site 717785005518 putative pore gating glutamate residue; other site 717785005519 putative H+/Cl- coupling transport residue; other site 717785005520 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 717785005521 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 717785005522 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 717785005523 homodimer interface [polypeptide binding]; other site 717785005524 NADP binding site [chemical binding]; other site 717785005525 substrate binding site [chemical binding]; other site 717785005526 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 717785005527 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 717785005528 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 717785005529 putative active site [active] 717785005530 putative substrate binding site [chemical binding]; other site 717785005531 putative cosubstrate binding site; other site 717785005532 catalytic site [active] 717785005533 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 717785005534 FAD binding site [chemical binding]; other site 717785005535 imidazolonepropionase; Validated; Region: PRK09356 717785005536 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 717785005537 active site 717785005538 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 717785005539 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 717785005540 FAD binding pocket [chemical binding]; other site 717785005541 FAD binding motif [chemical binding]; other site 717785005542 phosphate binding motif [ion binding]; other site 717785005543 beta-alpha-beta structure motif; other site 717785005544 NAD(p) ribose binding residues [chemical binding]; other site 717785005545 NAD binding pocket [chemical binding]; other site 717785005546 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 717785005547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785005548 catalytic loop [active] 717785005549 iron binding site [ion binding]; other site 717785005550 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 717785005551 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 717785005552 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 717785005553 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 717785005554 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 717785005555 B12 binding site [chemical binding]; other site 717785005556 cobalt ligand [ion binding]; other site 717785005557 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 717785005558 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 717785005559 Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798 717785005560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005562 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 717785005563 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 717785005564 dimerization interface [polypeptide binding]; other site 717785005565 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 717785005566 active site 717785005567 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785005568 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785005569 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785005570 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 717785005571 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 717785005572 putative dimer interface [polypeptide binding]; other site 717785005573 active site pocket [active] 717785005574 putative cataytic base [active] 717785005575 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 717785005576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785005577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005578 homodimer interface [polypeptide binding]; other site 717785005579 catalytic residue [active] 717785005580 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785005581 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 717785005582 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 717785005583 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 717785005584 active site 717785005585 SAM binding site [chemical binding]; other site 717785005586 homodimer interface [polypeptide binding]; other site 717785005587 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 717785005588 FMN binding site [chemical binding]; other site 717785005589 dimer interface [polypeptide binding]; other site 717785005590 cobyric acid synthase; Provisional; Region: PRK00784 717785005591 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 717785005592 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 717785005593 catalytic triad [active] 717785005594 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 717785005595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 717785005598 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785005599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 717785005600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785005601 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 717785005602 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 717785005603 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 717785005604 ATP binding site [chemical binding]; other site 717785005605 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 717785005606 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 717785005607 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 717785005608 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 717785005609 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 717785005610 Catalytic site [active] 717785005611 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 717785005612 methionine sulfoxide reductase A; Provisional; Region: PRK13014 717785005613 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785005614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 717785005615 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 717785005616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785005617 catalytic residue [active] 717785005618 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 717785005619 threonine dehydratase; Provisional; Region: PRK07334 717785005620 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 717785005621 tetramer interface [polypeptide binding]; other site 717785005622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005623 catalytic residue [active] 717785005624 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 717785005625 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 717785005626 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 717785005627 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785005628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785005629 dimerization interface [polypeptide binding]; other site 717785005630 putative DNA binding site [nucleotide binding]; other site 717785005631 putative Zn2+ binding site [ion binding]; other site 717785005632 AsnC family; Region: AsnC_trans_reg; pfam01037 717785005633 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785005634 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 717785005635 putative C-terminal domain interface [polypeptide binding]; other site 717785005636 putative GSH binding site (G-site) [chemical binding]; other site 717785005637 putative dimer interface [polypeptide binding]; other site 717785005638 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 717785005639 N-terminal domain interface [polypeptide binding]; other site 717785005640 dimer interface [polypeptide binding]; other site 717785005641 substrate binding pocket (H-site) [chemical binding]; other site 717785005642 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785005643 Catalytic site; other site 717785005644 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785005645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785005646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785005647 dimer interface [polypeptide binding]; other site 717785005648 phosphorylation site [posttranslational modification] 717785005649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005650 ATP binding site [chemical binding]; other site 717785005651 Mg2+ binding site [ion binding]; other site 717785005652 G-X-G motif; other site 717785005653 Predicted aspartyl protease [General function prediction only]; Region: COG3577 717785005654 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 717785005655 catalytic motif [active] 717785005656 Catalytic residue [active] 717785005657 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 717785005658 catalytic motif [active] 717785005659 Catalytic residue [active] 717785005660 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 717785005661 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 717785005662 active site 717785005663 substrate binding site [chemical binding]; other site 717785005664 metal binding site [ion binding]; metal-binding site 717785005665 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785005666 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 717785005667 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 717785005668 FMN binding site [chemical binding]; other site 717785005669 active site 717785005670 catalytic residues [active] 717785005671 substrate binding site [chemical binding]; other site 717785005672 LssY C-terminus; Region: LssY_C; pfam14067 717785005673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005674 C factor cell-cell signaling protein; Provisional; Region: PRK09009 717785005675 NAD(P) binding site [chemical binding]; other site 717785005676 active site 717785005677 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785005678 MarR family; Region: MarR_2; pfam12802 717785005679 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785005680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785005681 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785005682 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785005683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785005684 TPR repeat; Region: TPR_11; pfam13414 717785005685 binding surface 717785005686 TPR motif; other site 717785005687 TPR repeat; Region: TPR_11; pfam13414 717785005688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785005689 TPR motif; other site 717785005690 TPR repeat; Region: TPR_11; pfam13414 717785005691 TPR repeat; Region: TPR_11; pfam13414 717785005692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785005693 binding surface 717785005694 TPR motif; other site 717785005695 TPR repeat; Region: TPR_11; pfam13414 717785005696 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785005697 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785005698 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785005699 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785005700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005702 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785005703 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785005704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 717785005705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785005706 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785005707 Walker A/P-loop; other site 717785005708 ATP binding site [chemical binding]; other site 717785005709 Q-loop/lid; other site 717785005710 ABC transporter signature motif; other site 717785005711 Walker B; other site 717785005712 D-loop; other site 717785005713 H-loop/switch region; other site 717785005714 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 717785005715 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 717785005716 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 717785005717 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 717785005718 urea carboxylase; Region: urea_carbox; TIGR02712 717785005719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785005720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 717785005721 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 717785005722 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 717785005723 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 717785005724 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 717785005725 carboxyltransferase (CT) interaction site; other site 717785005726 biotinylation site [posttranslational modification]; other site 717785005727 allophanate hydrolase; Provisional; Region: PRK08186 717785005728 Amidase; Region: Amidase; cl11426 717785005729 Predicted secreted protein [Function unknown]; Region: COG5501 717785005730 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 717785005731 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 717785005732 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 717785005733 Moco binding site; other site 717785005734 metal coordination site [ion binding]; other site 717785005735 Cytochrome c; Region: Cytochrom_C; pfam00034 717785005736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785005737 S-adenosylmethionine binding site [chemical binding]; other site 717785005738 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 717785005739 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 717785005740 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 717785005741 dimer interface [polypeptide binding]; other site 717785005742 active site 717785005743 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785005744 catalytic residues [active] 717785005745 substrate binding site [chemical binding]; other site 717785005746 aminopeptidase N; Provisional; Region: pepN; PRK14015 717785005747 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 717785005748 active site 717785005749 Zn binding site [ion binding]; other site 717785005750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785005751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785005752 dimer interface [polypeptide binding]; other site 717785005753 phosphorylation site [posttranslational modification] 717785005754 Heavy-metal resistance; Region: Metal_resist; pfam13801 717785005755 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717785005756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785005757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785005758 DNA binding residues [nucleotide binding] 717785005759 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 717785005760 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785005761 metal binding triad; other site 717785005762 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785005763 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785005764 metal binding triad; other site 717785005765 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785005766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785005767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785005768 dimerization interface [polypeptide binding]; other site 717785005769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785005770 dimer interface [polypeptide binding]; other site 717785005771 phosphorylation site [posttranslational modification] 717785005772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005773 ATP binding site [chemical binding]; other site 717785005774 Mg2+ binding site [ion binding]; other site 717785005775 G-X-G motif; other site 717785005776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785005778 active site 717785005779 phosphorylation site [posttranslational modification] 717785005780 intermolecular recognition site; other site 717785005781 dimerization interface [polypeptide binding]; other site 717785005782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785005783 DNA binding site [nucleotide binding] 717785005784 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785005785 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717785005786 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785005787 protein binding site [polypeptide binding]; other site 717785005788 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785005789 protein binding site [polypeptide binding]; other site 717785005790 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 717785005791 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 717785005792 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 717785005793 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 717785005794 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 717785005795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785005796 binding surface 717785005797 TPR motif; other site 717785005798 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 717785005799 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 717785005800 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 717785005801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005802 ATP binding site [chemical binding]; other site 717785005803 Mg2+ binding site [ion binding]; other site 717785005804 G-X-G motif; other site 717785005805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785005806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785005807 active site 717785005808 phosphorylation site [posttranslational modification] 717785005809 intermolecular recognition site; other site 717785005810 dimerization interface [polypeptide binding]; other site 717785005811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785005812 DNA binding site [nucleotide binding] 717785005813 TIGR02594 family protein; Region: TIGR02594 717785005814 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 717785005815 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 717785005816 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 717785005817 Putative phage tail protein; Region: Phage-tail_3; pfam13550 717785005818 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 717785005819 NlpC/P60 family; Region: NLPC_P60; cl17555 717785005820 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 717785005821 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 717785005822 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 717785005823 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 717785005824 Phage-related minor tail protein [Function unknown]; Region: COG5281 717785005825 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 717785005826 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 717785005827 Phage major tail protein 2; Region: Phage_tail_2; cl11463 717785005828 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 717785005829 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 717785005830 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 717785005831 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785005832 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785005833 oligomerization interface [polypeptide binding]; other site 717785005834 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 717785005835 Phage capsid family; Region: Phage_capsid; pfam05065 717785005836 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 717785005837 Phage-related protein [Function unknown]; Region: COG4695 717785005838 Phage portal protein; Region: Phage_portal; pfam04860 717785005839 Uncharacterized conserved protein [Function unknown]; Region: COG5323 717785005840 Terminase-like family; Region: Terminase_6; pfam03237 717785005841 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 717785005842 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005844 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 717785005845 Predicted integral membrane protein [Function unknown]; Region: COG5436 717785005846 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 717785005847 Transglycosylase; Region: Transgly; pfam00912 717785005848 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 717785005849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 717785005850 hypothetical protein; Provisional; Region: PRK05170 717785005851 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 717785005852 DnaA box-binding interface [nucleotide binding]; other site 717785005853 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 717785005854 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 717785005855 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 717785005856 YciI-like protein; Reviewed; Region: PRK12866 717785005857 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785005858 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005859 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005860 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785005861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005862 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 717785005863 ATP-NAD kinase; Region: NAD_kinase; pfam01513 717785005864 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 717785005865 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 717785005866 putative FMN binding site [chemical binding]; other site 717785005867 von Willebrand factor type A domain; Region: VWA_2; pfam13519 717785005868 metal ion-dependent adhesion site (MIDAS); other site 717785005869 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717785005870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785005871 substrate binding pocket [chemical binding]; other site 717785005872 membrane-bound complex binding site; other site 717785005873 hinge residues; other site 717785005874 cystathionine beta-lyase; Provisional; Region: PRK05967 717785005875 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785005876 homodimer interface [polypeptide binding]; other site 717785005877 substrate-cofactor binding pocket; other site 717785005878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005879 catalytic residue [active] 717785005880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785005881 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005882 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785005883 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 717785005884 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 717785005885 nucleotide binding site [chemical binding]; other site 717785005886 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 717785005887 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 717785005888 active site 717785005889 DNA binding site [nucleotide binding] 717785005890 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 717785005891 DNA binding site [nucleotide binding] 717785005892 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 717785005893 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 717785005894 putative DNA binding site [nucleotide binding]; other site 717785005895 putative homodimer interface [polypeptide binding]; other site 717785005896 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 717785005897 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 717785005898 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 717785005899 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785005900 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 717785005901 alpha subunit interaction interface [polypeptide binding]; other site 717785005902 Walker A motif; other site 717785005903 ATP binding site [chemical binding]; other site 717785005904 Walker B motif; other site 717785005905 inhibitor binding site; inhibition site 717785005906 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785005907 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 717785005908 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 717785005909 gamma subunit interface [polypeptide binding]; other site 717785005910 epsilon subunit interface [polypeptide binding]; other site 717785005911 LBP interface [polypeptide binding]; other site 717785005912 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 717785005913 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 717785005914 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 717785005915 ATP synthase subunit C; Region: ATP-synt_C; cl00466 717785005916 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 717785005917 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 717785005918 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 717785005919 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785005920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717785005921 Walker A motif; other site 717785005922 ATP binding site [chemical binding]; other site 717785005923 Walker B motif; other site 717785005924 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785005925 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 717785005926 core domain interface [polypeptide binding]; other site 717785005927 delta subunit interface [polypeptide binding]; other site 717785005928 epsilon subunit interface [polypeptide binding]; other site 717785005929 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 717785005930 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785005931 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785005932 putative metal binding site; other site 717785005933 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785005934 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785005935 N-terminal plug; other site 717785005936 ligand-binding site [chemical binding]; other site 717785005937 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 717785005938 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 717785005939 active site 717785005940 metal binding site [ion binding]; metal-binding site 717785005941 nudix motif; other site 717785005942 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 717785005943 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 717785005944 Fe-S cluster binding site [ion binding]; other site 717785005945 active site 717785005946 CsbD-like; Region: CsbD; cl17424 717785005947 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 717785005948 Mechanosensitive ion channel; Region: MS_channel; pfam00924 717785005949 HD domain; Region: HD_4; pfam13328 717785005950 hypothetical protein; Provisional; Region: PRK10279 717785005951 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785005952 nucleophile elbow; other site 717785005953 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 717785005954 PRC-barrel domain; Region: PRC; pfam05239 717785005955 Low affinity iron permease; Region: Iron_permease; pfam04120 717785005956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785005958 active site 717785005959 phosphorylation site [posttranslational modification] 717785005960 intermolecular recognition site; other site 717785005961 dimerization interface [polypeptide binding]; other site 717785005962 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785005963 DNA binding residues [nucleotide binding] 717785005964 dimerization interface [polypeptide binding]; other site 717785005965 HAMP domain; Region: HAMP; pfam00672 717785005966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 717785005967 Histidine kinase; Region: HisKA_3; pfam07730 717785005968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005969 ATP binding site [chemical binding]; other site 717785005970 Mg2+ binding site [ion binding]; other site 717785005971 G-X-G motif; other site 717785005972 putative S-transferase; Provisional; Region: PRK11752 717785005973 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 717785005974 C-terminal domain interface [polypeptide binding]; other site 717785005975 GSH binding site (G-site) [chemical binding]; other site 717785005976 dimer interface [polypeptide binding]; other site 717785005977 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 717785005978 dimer interface [polypeptide binding]; other site 717785005979 N-terminal domain interface [polypeptide binding]; other site 717785005980 active site 717785005981 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 717785005982 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 717785005983 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 717785005984 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 717785005985 Nucleoside recognition; Region: Gate; pfam07670 717785005986 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 717785005987 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785005988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785005989 S-adenosylmethionine binding site [chemical binding]; other site 717785005990 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 717785005991 Helix-turn-helix domain; Region: HTH_18; pfam12833 717785005992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785005993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785005994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785005995 putative substrate translocation pore; other site 717785005996 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 717785005997 DHH family; Region: DHH; pfam01368 717785005998 DHHA1 domain; Region: DHHA1; pfam02272 717785005999 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 717785006000 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 717785006001 putative active site [active] 717785006002 homoserine dehydrogenase; Provisional; Region: PRK06349 717785006003 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 717785006004 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 717785006005 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 717785006006 aminotransferase; Validated; Region: PRK09148 717785006007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785006008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006009 homodimer interface [polypeptide binding]; other site 717785006010 catalytic residue [active] 717785006011 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 717785006012 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 717785006013 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 717785006014 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785006015 homodimer interface [polypeptide binding]; other site 717785006016 substrate-cofactor binding pocket; other site 717785006017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006018 catalytic residue [active] 717785006019 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 717785006020 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 717785006021 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 717785006022 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 717785006023 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 717785006024 CAP-like domain; other site 717785006025 active site 717785006026 primary dimer interface [polypeptide binding]; other site 717785006027 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785006028 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 717785006029 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 717785006030 classical (c) SDRs; Region: SDR_c; cd05233 717785006031 NAD(P) binding site [chemical binding]; other site 717785006032 active site 717785006033 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 717785006034 putative active site [active] 717785006035 putative metal binding residues [ion binding]; other site 717785006036 signature motif; other site 717785006037 putative dimer interface [polypeptide binding]; other site 717785006038 putative phosphate binding site [ion binding]; other site 717785006039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 717785006040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006041 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 717785006042 putative homodimer interface [polypeptide binding]; other site 717785006043 putative homotetramer interface [polypeptide binding]; other site 717785006044 putative allosteric switch controlling residues; other site 717785006045 putative metal binding site [ion binding]; other site 717785006046 putative homodimer-homodimer interface [polypeptide binding]; other site 717785006047 YHS domain; Region: YHS; pfam04945 717785006048 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717785006049 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785006050 Soluble P-type ATPase [General function prediction only]; Region: COG4087 717785006051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785006052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785006053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785006054 active site 717785006055 catalytic tetrad [active] 717785006056 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 717785006057 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 717785006058 Cytochrome P450; Region: p450; pfam00067 717785006059 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 717785006060 short chain dehydrogenase; Provisional; Region: PRK07890 717785006061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006062 NAD(P) binding site [chemical binding]; other site 717785006063 active site 717785006064 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 717785006065 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 717785006066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785006067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785006068 P-loop; other site 717785006069 Magnesium ion binding site [ion binding]; other site 717785006070 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 717785006071 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785006072 putative C-terminal domain interface [polypeptide binding]; other site 717785006073 putative GSH binding site [chemical binding]; other site 717785006074 putative dimer interface [polypeptide binding]; other site 717785006075 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 717785006076 putative N-terminal domain interface [polypeptide binding]; other site 717785006077 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 717785006078 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 717785006079 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 717785006080 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 717785006081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785006082 MarR family; Region: MarR_2; pfam12802 717785006083 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 717785006084 hypothetical protein; Provisional; Region: PRK07236 717785006085 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 717785006086 Domain of unknown function DUF21; Region: DUF21; pfam01595 717785006087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785006088 Transporter associated domain; Region: CorC_HlyC; smart01091 717785006089 ATP12 chaperone protein; Region: ATP12; cl02228 717785006090 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785006091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785006092 motif II; other site 717785006093 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 717785006094 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 717785006095 active site 717785006096 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 717785006097 Putative ParB-like nuclease; Region: ParBc_2; cl17538 717785006098 recombination factor protein RarA; Reviewed; Region: PRK13342 717785006099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785006100 Walker A motif; other site 717785006101 ATP binding site [chemical binding]; other site 717785006102 Walker B motif; other site 717785006103 arginine finger; other site 717785006104 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 717785006105 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 717785006106 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785006107 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717785006108 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785006109 protein binding site [polypeptide binding]; other site 717785006110 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785006111 protein binding site [polypeptide binding]; other site 717785006112 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785006113 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 717785006114 NADP binding site [chemical binding]; other site 717785006115 putative substrate binding site [chemical binding]; other site 717785006116 active site 717785006117 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 717785006118 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 717785006119 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 717785006120 alphaNTD - beta interaction site [polypeptide binding]; other site 717785006121 alphaNTD homodimer interface [polypeptide binding]; other site 717785006122 alphaNTD - beta' interaction site [polypeptide binding]; other site 717785006123 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 717785006124 30S ribosomal protein S11; Validated; Region: PRK05309 717785006125 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 717785006126 30S ribosomal protein S13; Region: bact_S13; TIGR03631 717785006127 adenylate kinase; Reviewed; Region: adk; PRK00279 717785006128 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 717785006129 AMP-binding site [chemical binding]; other site 717785006130 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 717785006131 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 717785006132 SecY translocase; Region: SecY; pfam00344 717785006133 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 717785006134 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 717785006135 23S rRNA binding site [nucleotide binding]; other site 717785006136 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 717785006137 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 717785006138 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 717785006139 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 717785006140 5S rRNA interface [nucleotide binding]; other site 717785006141 23S rRNA interface [nucleotide binding]; other site 717785006142 L5 interface [polypeptide binding]; other site 717785006143 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 717785006144 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717785006145 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717785006146 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 717785006147 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 717785006148 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 717785006149 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 717785006150 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 717785006151 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 717785006152 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 717785006153 RNA binding site [nucleotide binding]; other site 717785006154 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 717785006155 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 717785006156 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 717785006157 putative translocon interaction site; other site 717785006158 23S rRNA interface [nucleotide binding]; other site 717785006159 signal recognition particle (SRP54) interaction site; other site 717785006160 L23 interface [polypeptide binding]; other site 717785006161 trigger factor interaction site; other site 717785006162 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 717785006163 23S rRNA interface [nucleotide binding]; other site 717785006164 5S rRNA interface [nucleotide binding]; other site 717785006165 putative antibiotic binding site [chemical binding]; other site 717785006166 L25 interface [polypeptide binding]; other site 717785006167 L27 interface [polypeptide binding]; other site 717785006168 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 717785006169 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 717785006170 G-X-X-G motif; other site 717785006171 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 717785006172 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 717785006173 putative translocon binding site; other site 717785006174 protein-rRNA interface [nucleotide binding]; other site 717785006175 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 717785006176 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 717785006177 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 717785006178 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 717785006179 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 717785006180 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 717785006181 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 717785006182 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 717785006183 elongation factor Tu; Reviewed; Region: PRK00049 717785006184 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 717785006185 G1 box; other site 717785006186 GEF interaction site [polypeptide binding]; other site 717785006187 GTP/Mg2+ binding site [chemical binding]; other site 717785006188 Switch I region; other site 717785006189 G2 box; other site 717785006190 G3 box; other site 717785006191 Switch II region; other site 717785006192 G4 box; other site 717785006193 G5 box; other site 717785006194 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 717785006195 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 717785006196 Antibiotic Binding Site [chemical binding]; other site 717785006197 elongation factor G; Reviewed; Region: PRK00007 717785006198 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 717785006199 G1 box; other site 717785006200 putative GEF interaction site [polypeptide binding]; other site 717785006201 GTP/Mg2+ binding site [chemical binding]; other site 717785006202 Switch I region; other site 717785006203 G2 box; other site 717785006204 G3 box; other site 717785006205 Switch II region; other site 717785006206 G4 box; other site 717785006207 G5 box; other site 717785006208 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 717785006209 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 717785006210 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 717785006211 30S ribosomal protein S7; Validated; Region: PRK05302 717785006212 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 717785006213 S17 interaction site [polypeptide binding]; other site 717785006214 S8 interaction site; other site 717785006215 16S rRNA interaction site [nucleotide binding]; other site 717785006216 streptomycin interaction site [chemical binding]; other site 717785006217 23S rRNA interaction site [nucleotide binding]; other site 717785006218 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 717785006219 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 717785006220 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 717785006221 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 717785006222 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 717785006223 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 717785006224 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 717785006225 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 717785006226 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 717785006227 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 717785006228 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 717785006229 DNA binding site [nucleotide binding] 717785006230 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 717785006231 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 717785006232 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 717785006233 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 717785006234 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 717785006235 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 717785006236 RPB12 interaction site [polypeptide binding]; other site 717785006237 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 717785006238 RPB1 interaction site [polypeptide binding]; other site 717785006239 RPB11 interaction site [polypeptide binding]; other site 717785006240 RPB10 interaction site [polypeptide binding]; other site 717785006241 RPB3 interaction site [polypeptide binding]; other site 717785006242 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 717785006243 peripheral dimer interface [polypeptide binding]; other site 717785006244 core dimer interface [polypeptide binding]; other site 717785006245 L10 interface [polypeptide binding]; other site 717785006246 L11 interface [polypeptide binding]; other site 717785006247 putative EF-Tu interaction site [polypeptide binding]; other site 717785006248 putative EF-G interaction site [polypeptide binding]; other site 717785006249 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 717785006250 23S rRNA interface [nucleotide binding]; other site 717785006251 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 717785006252 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 717785006253 mRNA/rRNA interface [nucleotide binding]; other site 717785006254 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 717785006255 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 717785006256 23S rRNA interface [nucleotide binding]; other site 717785006257 L7/L12 interface [polypeptide binding]; other site 717785006258 putative thiostrepton binding site; other site 717785006259 L25 interface [polypeptide binding]; other site 717785006260 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 717785006261 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 717785006262 putative homodimer interface [polypeptide binding]; other site 717785006263 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 717785006264 heterodimer interface [polypeptide binding]; other site 717785006265 homodimer interface [polypeptide binding]; other site 717785006266 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 717785006267 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 717785006268 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 717785006269 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 717785006270 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 717785006271 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717785006272 glucosyltransferase MdoH; Provisional; Region: PRK05454 717785006273 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 717785006274 active site 717785006275 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 717785006276 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 717785006277 putative NAD(P) binding site [chemical binding]; other site 717785006278 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 717785006279 active site 717785006280 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785006281 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785006282 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 717785006283 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 717785006284 RibD C-terminal domain; Region: RibD_C; cl17279 717785006285 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 717785006286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785006287 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 717785006288 Walker A/P-loop; other site 717785006289 ATP binding site [chemical binding]; other site 717785006290 Q-loop/lid; other site 717785006291 ABC transporter signature motif; other site 717785006292 Walker B; other site 717785006293 D-loop; other site 717785006294 H-loop/switch region; other site 717785006295 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 717785006296 dimerization interface [polypeptide binding]; other site 717785006297 active site 717785006298 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 717785006299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785006300 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 717785006301 enoyl-CoA hydratase; Validated; Region: PRK08139 717785006302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785006303 substrate binding site [chemical binding]; other site 717785006304 oxyanion hole (OAH) forming residues; other site 717785006305 trimer interface [polypeptide binding]; other site 717785006306 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 717785006307 23S rRNA interface [nucleotide binding]; other site 717785006308 L3 interface [polypeptide binding]; other site 717785006309 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 717785006310 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 717785006311 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 717785006312 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 717785006313 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 717785006314 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 717785006315 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 717785006316 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785006317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006318 dimerization interface [polypeptide binding]; other site 717785006319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 717785006320 Histidine kinase; Region: HisKA_3; pfam07730 717785006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785006322 ATP binding site [chemical binding]; other site 717785006323 Mg2+ binding site [ion binding]; other site 717785006324 G-X-G motif; other site 717785006325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785006326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006327 active site 717785006328 phosphorylation site [posttranslational modification] 717785006329 intermolecular recognition site; other site 717785006330 dimerization interface [polypeptide binding]; other site 717785006331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785006332 DNA binding residues [nucleotide binding] 717785006333 dimerization interface [polypeptide binding]; other site 717785006334 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785006335 putative hydrophobic ligand binding site [chemical binding]; other site 717785006336 protein interface [polypeptide binding]; other site 717785006337 gate; other site 717785006338 two-component response regulator; Provisional; Region: PRK09191 717785006339 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 717785006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006341 active site 717785006342 phosphorylation site [posttranslational modification] 717785006343 intermolecular recognition site; other site 717785006344 dimerization interface [polypeptide binding]; other site 717785006345 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785006346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785006347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785006348 DNA binding residues [nucleotide binding] 717785006349 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717785006350 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717785006351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006352 dimerization interface [polypeptide binding]; other site 717785006353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006354 dimerization interface [polypeptide binding]; other site 717785006355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006356 dimerization interface [polypeptide binding]; other site 717785006357 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717785006358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006359 dimerization interface [polypeptide binding]; other site 717785006360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006361 dimerization interface [polypeptide binding]; other site 717785006362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006363 dimerization interface [polypeptide binding]; other site 717785006364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006365 dimerization interface [polypeptide binding]; other site 717785006366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006367 dimerization interface [polypeptide binding]; other site 717785006368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785006369 dimerization interface [polypeptide binding]; other site 717785006370 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 717785006371 GAF domain; Region: GAF; pfam01590 717785006372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785006373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785006374 dimer interface [polypeptide binding]; other site 717785006375 phosphorylation site [posttranslational modification] 717785006376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785006377 ATP binding site [chemical binding]; other site 717785006378 Mg2+ binding site [ion binding]; other site 717785006379 G-X-G motif; other site 717785006380 Response regulator receiver domain; Region: Response_reg; pfam00072 717785006381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006382 active site 717785006383 phosphorylation site [posttranslational modification] 717785006384 intermolecular recognition site; other site 717785006385 dimerization interface [polypeptide binding]; other site 717785006386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006388 active site 717785006389 phosphorylation site [posttranslational modification] 717785006390 intermolecular recognition site; other site 717785006391 Response regulator receiver domain; Region: Response_reg; pfam00072 717785006392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006393 active site 717785006394 phosphorylation site [posttranslational modification] 717785006395 intermolecular recognition site; other site 717785006396 dimerization interface [polypeptide binding]; other site 717785006397 Response regulator receiver domain; Region: Response_reg; pfam00072 717785006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006399 active site 717785006400 phosphorylation site [posttranslational modification] 717785006401 intermolecular recognition site; other site 717785006402 dimerization interface [polypeptide binding]; other site 717785006403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 717785006404 PAS fold; Region: PAS_3; pfam08447 717785006405 putative active site [active] 717785006406 heme pocket [chemical binding]; other site 717785006407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785006408 HWE histidine kinase; Region: HWE_HK; pfam07536 717785006409 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717785006410 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785006411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785006412 active site 717785006413 phosphorylation site [posttranslational modification] 717785006414 intermolecular recognition site; other site 717785006415 dimerization interface [polypeptide binding]; other site 717785006416 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 717785006417 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 717785006418 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 717785006419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785006420 HWE histidine kinase; Region: HWE_HK; smart00911 717785006421 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 717785006422 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 717785006423 active site 717785006424 homotetramer interface [polypeptide binding]; other site 717785006425 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 717785006426 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 717785006427 nucleotide binding site [chemical binding]; other site 717785006428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 717785006429 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 717785006430 ATP binding site [chemical binding]; other site 717785006431 substrate binding site [chemical binding]; other site 717785006432 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 717785006433 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 717785006434 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785006435 putative metal binding site; other site 717785006436 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785006437 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 717785006438 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 717785006439 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 717785006440 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 717785006441 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 717785006442 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785006443 N-terminal plug; other site 717785006444 ligand-binding site [chemical binding]; other site 717785006445 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 717785006446 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785006447 Sel1-like repeats; Region: SEL1; smart00671 717785006448 Sel1-like repeats; Region: SEL1; smart00671 717785006449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 717785006450 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 717785006451 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 717785006452 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 717785006453 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 717785006454 ApbE family; Region: ApbE; pfam02424 717785006455 integrase; Provisional; Region: PRK09692 717785006456 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785006457 active site 717785006458 Int/Topo IB signature motif; other site 717785006459 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 717785006460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785006461 AAA domain; Region: AAA_21; pfam13304 717785006462 Walker A/P-loop; other site 717785006463 ATP binding site [chemical binding]; other site 717785006464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785006465 ABC transporter signature motif; other site 717785006466 Walker B; other site 717785006467 D-loop; other site 717785006468 H-loop/switch region; other site 717785006469 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 717785006470 GIY-YIG motif/motif A; other site 717785006471 putative active site [active] 717785006472 putative metal binding site [ion binding]; other site 717785006473 Amino acid permease; Region: AA_permease_2; pfam13520 717785006474 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 717785006475 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 717785006476 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 717785006477 DNA binding residues [nucleotide binding] 717785006478 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 717785006479 IHF dimer interface [polypeptide binding]; other site 717785006480 IHF - DNA interface [nucleotide binding]; other site 717785006481 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 717785006482 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785006483 dimer interface [polypeptide binding]; other site 717785006484 active site 717785006485 CoA binding pocket [chemical binding]; other site 717785006486 putative phosphate acyltransferase; Provisional; Region: PRK05331 717785006487 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 717785006488 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 717785006489 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 717785006490 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 717785006491 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 717785006492 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 717785006493 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 717785006494 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 717785006495 homotrimer interaction site [polypeptide binding]; other site 717785006496 putative active site [active] 717785006497 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 717785006498 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 717785006499 manganese transport protein MntH; Reviewed; Region: PRK00701 717785006500 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 717785006501 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 717785006502 Glucose inhibited division protein A; Region: GIDA; pfam01134 717785006503 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717785006504 active site 717785006505 catalytic triad [active] 717785006506 oxyanion hole [active] 717785006507 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 717785006508 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 717785006509 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 717785006510 Protein export membrane protein; Region: SecD_SecF; pfam02355 717785006511 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 717785006512 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 717785006513 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 717785006514 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 717785006515 Protein of unknown function (DUF815); Region: DUF815; pfam05673 717785006516 Walker A motif; other site 717785006517 ATP binding site [chemical binding]; other site 717785006518 Walker B motif; other site 717785006519 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 717785006520 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 717785006521 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717785006522 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785006523 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 717785006524 seryl-tRNA synthetase; Provisional; Region: PRK05431 717785006525 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 717785006526 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 717785006527 dimer interface [polypeptide binding]; other site 717785006528 active site 717785006529 motif 1; other site 717785006530 motif 2; other site 717785006531 motif 3; other site 717785006532 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 717785006533 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 717785006534 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 717785006535 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 717785006536 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 717785006537 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 717785006538 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 717785006539 Sporulation related domain; Region: SPOR; pfam05036 717785006540 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 717785006541 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 717785006542 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 717785006543 active site 717785006544 HIGH motif; other site 717785006545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785006546 KMSK motif region; other site 717785006547 tRNA binding surface [nucleotide binding]; other site 717785006548 DALR anticodon binding domain; Region: DALR_1; smart00836 717785006549 anticodon binding site; other site 717785006550 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 717785006551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717785006552 Zn2+ binding site [ion binding]; other site 717785006553 Mg2+ binding site [ion binding]; other site 717785006554 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 717785006555 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 717785006556 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 717785006557 putative catalytic site [active] 717785006558 putative phosphate binding site [ion binding]; other site 717785006559 active site 717785006560 metal binding site A [ion binding]; metal-binding site 717785006561 DNA binding site [nucleotide binding] 717785006562 putative AP binding site [nucleotide binding]; other site 717785006563 putative metal binding site B [ion binding]; other site 717785006564 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785006565 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 717785006566 Peptidase family M48; Region: Peptidase_M48; cl12018 717785006567 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 717785006568 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785006569 NAD(P) binding site [chemical binding]; other site 717785006570 active site 717785006571 Predicted transcriptional regulators [Transcription]; Region: COG1733 717785006572 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 717785006573 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 717785006574 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 717785006575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 717785006576 HIGH motif; other site 717785006577 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 717785006578 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 717785006579 active site 717785006580 KMSKS motif; other site 717785006581 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 717785006582 tRNA binding surface [nucleotide binding]; other site 717785006583 anticodon binding site; other site 717785006584 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 717785006585 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 717785006586 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 717785006587 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 717785006588 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 717785006589 Methyltransferase domain; Region: Methyltransf_18; pfam12847 717785006590 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 717785006591 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 717785006592 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 717785006593 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 717785006594 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 717785006595 Low-spin heme binding site [chemical binding]; other site 717785006596 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 717785006597 D-pathway; other site 717785006598 Putative water exit pathway; other site 717785006599 Binuclear center (active site) [active] 717785006600 K-pathway; other site 717785006601 Putative proton exit pathway; other site 717785006602 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785006603 Cytochrome c553 [Energy production and conversion]; Region: COG2863 717785006604 Cytochrome c; Region: Cytochrom_C; cl11414 717785006605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785006606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785006607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785006608 dimerization interface [polypeptide binding]; other site 717785006609 formate dehydrogenase; Provisional; Region: PRK07574 717785006610 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 717785006611 dimerization interface [polypeptide binding]; other site 717785006612 ligand binding site [chemical binding]; other site 717785006613 NAD binding site [chemical binding]; other site 717785006614 catalytic site [active] 717785006615 cyanate hydratase; Validated; Region: PRK02866 717785006616 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 717785006617 oligomer interface [polypeptide binding]; other site 717785006618 active site 717785006619 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 717785006620 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 717785006621 Cl- selectivity filter; other site 717785006622 Cl- binding residues [ion binding]; other site 717785006623 pore gating glutamate residue; other site 717785006624 dimer interface [polypeptide binding]; other site 717785006625 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 717785006626 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785006627 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785006628 [2Fe-2S] cluster binding site [ion binding]; other site 717785006629 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 717785006630 hydrophobic ligand binding site; other site 717785006631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785006632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785006633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785006634 dimerization interface [polypeptide binding]; other site 717785006635 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785006636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 717785006637 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785006638 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 717785006639 putative ligand binding site [chemical binding]; other site 717785006640 Transcriptional regulators [Transcription]; Region: FadR; COG2186 717785006641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785006642 DNA-binding site [nucleotide binding]; DNA binding site 717785006643 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 717785006644 Amino acid permease; Region: AA_permease_2; pfam13520 717785006645 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785006646 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 717785006647 FMN-binding pocket [chemical binding]; other site 717785006648 flavin binding motif; other site 717785006649 phosphate binding motif [ion binding]; other site 717785006650 beta-alpha-beta structure motif; other site 717785006651 NAD binding pocket [chemical binding]; other site 717785006652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785006653 catalytic loop [active] 717785006654 iron binding site [ion binding]; other site 717785006655 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 717785006656 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785006657 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785006658 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785006659 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 717785006660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785006661 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 717785006662 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 717785006663 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785006664 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785006665 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 717785006666 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 717785006667 NADP binding site [chemical binding]; other site 717785006668 dimer interface [polypeptide binding]; other site 717785006669 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 717785006670 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 717785006671 dimer interface [polypeptide binding]; other site 717785006672 putative tRNA-binding site [nucleotide binding]; other site 717785006673 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 717785006674 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 717785006675 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 717785006676 FecR protein; Region: FecR; pfam04773 717785006677 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 717785006678 CHASE2 domain; Region: CHASE2; pfam05226 717785006679 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 717785006680 cyclase homology domain; Region: CHD; cd07302 717785006681 nucleotidyl binding site; other site 717785006682 metal binding site [ion binding]; metal-binding site 717785006683 dimer interface [polypeptide binding]; other site 717785006684 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 717785006685 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 717785006686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785006687 classical (c) SDRs; Region: SDR_c; cd05233 717785006688 NAD(P) binding site [chemical binding]; other site 717785006689 active site 717785006690 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785006691 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785006692 N-terminal plug; other site 717785006693 ligand-binding site [chemical binding]; other site 717785006694 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 717785006695 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 717785006696 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 717785006697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785006698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785006699 putative aminotransferase; Validated; Region: PRK07480 717785006700 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785006701 inhibitor-cofactor binding pocket; inhibition site 717785006702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006703 catalytic residue [active] 717785006704 Peptidase C26; Region: Peptidase_C26; pfam07722 717785006705 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 717785006706 catalytic triad [active] 717785006707 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785006708 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785006709 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785006710 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 717785006711 NAD(P) binding site [chemical binding]; other site 717785006712 catalytic residues [active] 717785006713 succinic semialdehyde dehydrogenase; Region: PLN02278 717785006714 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 717785006715 tetramerization interface [polypeptide binding]; other site 717785006716 NAD(P) binding site [chemical binding]; other site 717785006717 catalytic residues [active] 717785006718 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 717785006719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785006720 inhibitor-cofactor binding pocket; inhibition site 717785006721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006722 catalytic residue [active] 717785006723 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 717785006724 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785006725 inhibitor-cofactor binding pocket; inhibition site 717785006726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006727 catalytic residue [active] 717785006728 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 717785006729 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 717785006730 tetrameric interface [polypeptide binding]; other site 717785006731 NAD binding site [chemical binding]; other site 717785006732 catalytic residues [active] 717785006733 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 717785006734 heme-binding site [chemical binding]; other site 717785006735 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717785006736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717785006737 dimer interface [polypeptide binding]; other site 717785006738 putative CheW interface [polypeptide binding]; other site 717785006739 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 717785006740 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 717785006741 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 717785006742 hexamer interface [polypeptide binding]; other site 717785006743 ligand binding site [chemical binding]; other site 717785006744 putative active site [active] 717785006745 NAD(P) binding site [chemical binding]; other site 717785006746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785006747 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 717785006748 putative Zn2+ binding site [ion binding]; other site 717785006749 putative DNA binding site [nucleotide binding]; other site 717785006750 AsnC family; Region: AsnC_trans_reg; pfam01037 717785006751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785006752 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785006753 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006754 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 717785006755 thiamine monophosphate kinase; Provisional; Region: PRK05731 717785006756 ATP binding site [chemical binding]; other site 717785006757 dimerization interface [polypeptide binding]; other site 717785006758 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 717785006759 putative RNA binding site [nucleotide binding]; other site 717785006760 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 717785006761 homopentamer interface [polypeptide binding]; other site 717785006762 active site 717785006763 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 717785006764 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 717785006765 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 717785006766 dimerization interface [polypeptide binding]; other site 717785006767 active site 717785006768 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 717785006769 Lumazine binding domain; Region: Lum_binding; pfam00677 717785006770 Lumazine binding domain; Region: Lum_binding; pfam00677 717785006771 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 717785006772 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 717785006773 catalytic motif [active] 717785006774 Zn binding site [ion binding]; other site 717785006775 RibD C-terminal domain; Region: RibD_C; cl17279 717785006776 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 717785006777 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 717785006778 ATP cone domain; Region: ATP-cone; pfam03477 717785006779 Predicted transcriptional regulators [Transcription]; Region: COG1733 717785006780 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 717785006781 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 717785006782 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785006783 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 717785006784 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 717785006785 dimer interface [polypeptide binding]; other site 717785006786 active site 717785006787 glycine-pyridoxal phosphate binding site [chemical binding]; other site 717785006788 folate binding site [chemical binding]; other site 717785006789 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 717785006790 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 717785006791 substrate-cofactor binding pocket; other site 717785006792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006793 catalytic residue [active] 717785006794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785006795 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785006796 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006797 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006798 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 717785006799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785006800 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 717785006801 substrate binding site [chemical binding]; other site 717785006802 oxyanion hole (OAH) forming residues; other site 717785006803 trimer interface [polypeptide binding]; other site 717785006804 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 717785006805 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785006806 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785006807 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 717785006808 dimer interface [polypeptide binding]; other site 717785006809 allosteric magnesium binding site [ion binding]; other site 717785006810 active site 717785006811 aspartate-rich active site metal binding site; other site 717785006812 Schiff base residues; other site 717785006813 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 717785006814 NADH dehydrogenase; Validated; Region: PRK08183 717785006815 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 717785006816 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 717785006817 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006818 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 717785006819 active site 717785006820 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006821 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006822 TSCPD domain; Region: TSCPD; pfam12637 717785006823 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 717785006824 GIY-YIG motif/motif A; other site 717785006825 putative active site [active] 717785006826 putative metal binding site [ion binding]; other site 717785006827 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785006828 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 717785006829 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 717785006830 putative MPT binding site; other site 717785006831 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 717785006832 methionine sulfoxide reductase B; Provisional; Region: PRK00222 717785006833 SelR domain; Region: SelR; pfam01641 717785006834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785006835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785006836 metal binding site [ion binding]; metal-binding site 717785006837 active site 717785006838 I-site; other site 717785006839 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785006840 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 717785006841 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785006842 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785006843 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 717785006844 Protein export membrane protein; Region: SecD_SecF; cl14618 717785006845 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 717785006846 Protein export membrane protein; Region: SecD_SecF; cl14618 717785006847 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 717785006848 O-Antigen ligase; Region: Wzy_C; pfam04932 717785006849 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785006850 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785006851 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785006852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006853 active site 717785006854 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 717785006855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785006856 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 717785006857 intersubunit interface [polypeptide binding]; other site 717785006858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785006859 DNA binding residues [nucleotide binding] 717785006860 dimerization interface [polypeptide binding]; other site 717785006861 Bacterial sugar transferase; Region: Bac_transf; pfam02397 717785006862 Acyltransferase family; Region: Acyl_transf_3; pfam01757 717785006863 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785006864 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 717785006865 putative active site [active] 717785006866 putative metal binding site [ion binding]; other site 717785006867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006868 active site 717785006869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006870 active site 717785006871 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785006872 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 717785006873 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 717785006874 Walker A/P-loop; other site 717785006875 ATP binding site [chemical binding]; other site 717785006876 Q-loop/lid; other site 717785006877 ABC transporter signature motif; other site 717785006878 Walker B; other site 717785006879 D-loop; other site 717785006880 H-loop/switch region; other site 717785006881 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 717785006882 putative carbohydrate binding site [chemical binding]; other site 717785006883 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 717785006884 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717785006885 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785006886 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785006887 inhibitor-cofactor binding pocket; inhibition site 717785006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006889 catalytic residue [active] 717785006890 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785006891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006892 NAD(P) binding site [chemical binding]; other site 717785006893 active site 717785006894 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785006895 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785006896 inhibitor-cofactor binding pocket; inhibition site 717785006897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006898 catalytic residue [active] 717785006899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 717785006900 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 717785006901 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 717785006902 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 717785006903 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 717785006904 putative trimer interface [polypeptide binding]; other site 717785006905 putative active site [active] 717785006906 putative substrate binding site [chemical binding]; other site 717785006907 putative CoA binding site [chemical binding]; other site 717785006908 Chain length determinant protein; Region: Wzz; pfam02706 717785006909 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 717785006910 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785006911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006912 active site 717785006913 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 717785006914 colanic acid exporter; Provisional; Region: PRK10459 717785006915 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 717785006916 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785006917 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 717785006918 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 717785006919 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 717785006920 Ligand binding site; other site 717785006921 hypothetical protein; Validated; Region: PRK08238 717785006922 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 717785006923 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 717785006924 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717785006925 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 717785006926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 717785006927 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 717785006928 acyl-activating enzyme (AAE) consensus motif; other site 717785006929 AMP binding site [chemical binding]; other site 717785006930 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 717785006931 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 717785006932 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006933 putative trimer interface [polypeptide binding]; other site 717785006934 putative CoA binding site [chemical binding]; other site 717785006935 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006936 putative trimer interface [polypeptide binding]; other site 717785006937 putative CoA binding site [chemical binding]; other site 717785006938 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006939 putative trimer interface [polypeptide binding]; other site 717785006940 putative CoA binding site [chemical binding]; other site 717785006941 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 717785006942 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717785006943 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785006944 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 717785006945 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785006946 Predicted dehydrogenase [General function prediction only]; Region: COG0579 717785006947 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785006948 FRG domain; Region: FRG; pfam08867 717785006949 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 717785006950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785006951 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 717785006952 putative NAD(P) binding site [chemical binding]; other site 717785006953 active site 717785006954 putative substrate binding site [chemical binding]; other site 717785006955 hypothetical protein; Provisional; Region: PRK06185 717785006956 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785006957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785006958 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 717785006959 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 717785006960 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 717785006961 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 717785006962 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785006963 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785006964 P-loop; other site 717785006965 Magnesium ion binding site [ion binding]; other site 717785006966 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785006967 Magnesium ion binding site [ion binding]; other site 717785006968 LexA repressor; Validated; Region: PRK00215 717785006969 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 717785006970 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 717785006971 Catalytic site [active] 717785006972 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 717785006973 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 717785006974 Competence protein; Region: Competence; pfam03772 717785006975 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785006976 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 717785006977 active site 717785006978 HIGH motif; other site 717785006979 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785006980 active site 717785006981 KMSKS motif; other site 717785006982 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 717785006983 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 717785006984 dimer interface [polypeptide binding]; other site 717785006985 active site 717785006986 citrylCoA binding site [chemical binding]; other site 717785006987 NADH binding [chemical binding]; other site 717785006988 cationic pore residues; other site 717785006989 oxalacetate/citrate binding site [chemical binding]; other site 717785006990 coenzyme A binding site [chemical binding]; other site 717785006991 catalytic triad [active] 717785006992 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 717785006993 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 717785006994 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 717785006995 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 717785006996 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 717785006997 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 717785006998 active site 717785006999 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 717785007000 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 717785007001 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 717785007002 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 717785007003 trimer interface [polypeptide binding]; other site 717785007004 active site 717785007005 UDP-GlcNAc binding site [chemical binding]; other site 717785007006 lipid binding site [chemical binding]; lipid-binding site 717785007007 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 717785007008 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 717785007009 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 717785007010 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 717785007011 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 717785007012 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 717785007013 Surface antigen; Region: Bac_surface_Ag; pfam01103 717785007014 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 717785007015 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 717785007016 active site 717785007017 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 717785007018 protein binding site [polypeptide binding]; other site 717785007019 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 717785007020 putative substrate binding region [chemical binding]; other site 717785007021 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 717785007022 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 717785007023 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 717785007024 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 717785007025 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 717785007026 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 717785007027 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 717785007028 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 717785007029 catalytic residue [active] 717785007030 putative FPP diphosphate binding site; other site 717785007031 putative FPP binding hydrophobic cleft; other site 717785007032 dimer interface [polypeptide binding]; other site 717785007033 putative IPP diphosphate binding site; other site 717785007034 ribosome recycling factor; Reviewed; Region: frr; PRK00083 717785007035 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 717785007036 hinge region; other site 717785007037 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 717785007038 putative nucleotide binding site [chemical binding]; other site 717785007039 uridine monophosphate binding site [chemical binding]; other site 717785007040 homohexameric interface [polypeptide binding]; other site 717785007041 elongation factor Ts; Provisional; Region: tsf; PRK09377 717785007042 UBA/TS-N domain; Region: UBA; pfam00627 717785007043 Elongation factor TS; Region: EF_TS; pfam00889 717785007044 Elongation factor TS; Region: EF_TS; pfam00889 717785007045 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 717785007046 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 717785007047 rRNA interaction site [nucleotide binding]; other site 717785007048 S8 interaction site; other site 717785007049 putative laminin-1 binding site; other site 717785007050 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785007051 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 717785007052 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 717785007053 putative active site [active] 717785007054 putative PHP Thumb interface [polypeptide binding]; other site 717785007055 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 717785007056 generic binding surface II; other site 717785007057 generic binding surface I; other site 717785007058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785007059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785007060 Walker A/P-loop; other site 717785007061 ATP binding site [chemical binding]; other site 717785007062 Q-loop/lid; other site 717785007063 ABC transporter signature motif; other site 717785007064 Walker B; other site 717785007065 D-loop; other site 717785007066 H-loop/switch region; other site 717785007067 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 717785007068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785007069 FtsX-like permease family; Region: FtsX; pfam02687 717785007070 prolyl-tRNA synthetase; Provisional; Region: PRK08661 717785007071 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 717785007072 dimer interface [polypeptide binding]; other site 717785007073 motif 1; other site 717785007074 active site 717785007075 motif 2; other site 717785007076 motif 3; other site 717785007077 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 717785007078 anticodon binding site; other site 717785007079 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 717785007080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785007081 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 717785007082 dimer interface [polypeptide binding]; other site 717785007083 substrate binding site [chemical binding]; other site 717785007084 metal binding site [ion binding]; metal-binding site 717785007085 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 717785007086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785007087 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 717785007088 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 717785007089 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 717785007090 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 717785007091 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 717785007092 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 717785007093 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 717785007094 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 717785007095 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 717785007096 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 717785007097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 717785007098 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 717785007099 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 717785007100 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 717785007101 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 717785007102 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 717785007103 4Fe-4S binding domain; Region: Fer4; pfam00037 717785007104 4Fe-4S binding domain; Region: Fer4; pfam00037 717785007105 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 717785007106 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 717785007107 NADH dehydrogenase subunit G; Validated; Region: PRK09130 717785007108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785007109 catalytic loop [active] 717785007110 iron binding site [ion binding]; other site 717785007111 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 717785007112 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 717785007113 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 717785007114 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 717785007115 SLBB domain; Region: SLBB; pfam10531 717785007116 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 717785007117 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 717785007118 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 717785007119 putative dimer interface [polypeptide binding]; other site 717785007120 [2Fe-2S] cluster binding site [ion binding]; other site 717785007121 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785007122 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 717785007123 putative hydrophobic ligand binding site [chemical binding]; other site 717785007124 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 717785007125 NADH dehydrogenase subunit D; Validated; Region: PRK06075 717785007126 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717785007127 subunit interaction site [polypeptide binding]; other site 717785007128 PHB binding site; other site 717785007129 CoenzymeA binding site [chemical binding]; other site 717785007130 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 717785007131 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 717785007132 NADH dehydrogenase subunit B; Validated; Region: PRK06411 717785007133 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 717785007134 Dystroglycan (Dystrophin-associated glycoprotein 1); Region: DAG1; pfam05454 717785007135 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 717785007136 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 717785007137 LTXXQ motif family protein; Region: LTXXQ; pfam07813 717785007138 LTXXQ motif family protein; Region: LTXXQ; pfam07813 717785007139 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 717785007140 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 717785007141 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 717785007142 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 717785007143 Predicted ATPase [General function prediction only]; Region: COG3911 717785007144 AAA domain; Region: AAA_28; pfam13521 717785007145 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 717785007146 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 717785007147 IHF dimer interface [polypeptide binding]; other site 717785007148 IHF - DNA interface [nucleotide binding]; other site 717785007149 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 717785007150 Found in ATP-dependent protease La (LON); Region: LON; smart00464 717785007151 Found in ATP-dependent protease La (LON); Region: LON; smart00464 717785007152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785007153 Walker A motif; other site 717785007154 ATP binding site [chemical binding]; other site 717785007155 Walker B motif; other site 717785007156 arginine finger; other site 717785007157 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717785007158 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 717785007159 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 717785007160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785007161 Walker A motif; other site 717785007162 ATP binding site [chemical binding]; other site 717785007163 Walker B motif; other site 717785007164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 717785007165 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 717785007166 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 717785007167 oligomer interface [polypeptide binding]; other site 717785007168 active site residues [active] 717785007169 trigger factor; Provisional; Region: tig; PRK01490 717785007170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 717785007171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 717785007172 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 717785007173 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 717785007174 molybdopterin cofactor binding site; other site 717785007175 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 717785007176 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 717785007177 molybdopterin cofactor binding site; other site 717785007178 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 717785007179 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 717785007180 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 717785007181 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 717785007182 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 717785007183 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 717785007184 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 717785007185 selenophosphate synthetase; Provisional; Region: PRK00943 717785007186 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 717785007187 dimerization interface [polypeptide binding]; other site 717785007188 putative ATP binding site [chemical binding]; other site 717785007189 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 717785007190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785007191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785007192 active site 717785007193 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 717785007194 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 717785007195 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 717785007196 G1 box; other site 717785007197 putative GEF interaction site [polypeptide binding]; other site 717785007198 GTP/Mg2+ binding site [chemical binding]; other site 717785007199 Switch I region; other site 717785007200 G2 box; other site 717785007201 G3 box; other site 717785007202 Switch II region; other site 717785007203 G4 box; other site 717785007204 G5 box; other site 717785007205 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 717785007206 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 717785007207 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 717785007208 potential RNA location (tRNA-U) that overlaps protein (Selenocysteine-specific translation elongation factor [Hyphomicrobium sp. MC1]) 717785007209 selenocysteine synthase; Provisional; Region: PRK04311 717785007210 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 717785007211 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 717785007212 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 717785007213 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 717785007214 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785007215 ligand binding site; other site 717785007216 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 717785007217 putative active site [active] 717785007218 YdjC motif; other site 717785007219 Mg binding site [ion binding]; other site 717785007220 putative homodimer interface [polypeptide binding]; other site 717785007221 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 717785007222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785007223 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 717785007224 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 717785007225 active site residue [active] 717785007226 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 717785007227 active site residue [active] 717785007228 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 717785007229 catalytic residues [active] 717785007230 dimer interface [polypeptide binding]; other site 717785007231 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 717785007232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785007233 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785007234 DevC protein; Region: devC; TIGR01185 717785007235 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785007236 FtsX-like permease family; Region: FtsX; pfam02687 717785007237 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785007238 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785007239 Walker A/P-loop; other site 717785007240 ATP binding site [chemical binding]; other site 717785007241 Q-loop/lid; other site 717785007242 ABC transporter signature motif; other site 717785007243 Walker B; other site 717785007244 D-loop; other site 717785007245 H-loop/switch region; other site 717785007246 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 717785007247 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785007248 NAD binding site [chemical binding]; other site 717785007249 homotetramer interface [polypeptide binding]; other site 717785007250 homodimer interface [polypeptide binding]; other site 717785007251 substrate binding site [chemical binding]; other site 717785007252 active site 717785007253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785007254 catalytic core [active] 717785007255 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 717785007256 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 717785007257 Tetramer interface [polypeptide binding]; other site 717785007258 active site 717785007259 FMN-binding site [chemical binding]; other site 717785007260 NAD-dependent deacetylase; Provisional; Region: PRK00481 717785007261 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 717785007262 NAD+ binding site [chemical binding]; other site 717785007263 substrate binding site [chemical binding]; other site 717785007264 Zn binding site [ion binding]; other site 717785007265 TRAM domain; Region: TRAM; cl01282 717785007266 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 717785007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785007268 S-adenosylmethionine binding site [chemical binding]; other site 717785007269 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 717785007270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785007271 RNA binding surface [nucleotide binding]; other site 717785007272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785007273 S-adenosylmethionine binding site [chemical binding]; other site 717785007274 Predicted membrane protein [Function unknown]; Region: COG2259 717785007275 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 717785007276 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 717785007277 TPP-binding site; other site 717785007278 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785007279 PYR/PP interface [polypeptide binding]; other site 717785007280 dimer interface [polypeptide binding]; other site 717785007281 TPP binding site [chemical binding]; other site 717785007282 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785007283 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 717785007284 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 717785007285 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 717785007286 putative active site [active] 717785007287 Zn binding site [ion binding]; other site 717785007288 short chain dehydrogenase; Provisional; Region: PRK08278 717785007289 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 717785007290 NAD(P) binding site [chemical binding]; other site 717785007291 homodimer interface [polypeptide binding]; other site 717785007292 active site 717785007293 enoyl-CoA hydratase; Provisional; Region: PRK06688 717785007294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785007295 substrate binding site [chemical binding]; other site 717785007296 oxyanion hole (OAH) forming residues; other site 717785007297 trimer interface [polypeptide binding]; other site 717785007298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785007299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785007300 active site 717785007301 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 717785007302 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 717785007303 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 717785007304 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 717785007305 Uncharacterized conserved protein [Function unknown]; Region: COG2135 717785007306 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 717785007307 LysE type translocator; Region: LysE; cl00565 717785007308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 717785007309 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785007310 dihydroorotase; Validated; Region: PRK09060 717785007311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 717785007312 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 717785007313 active site 717785007314 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 717785007315 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 717785007316 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 717785007317 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 717785007318 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 717785007319 quinolinate synthetase; Provisional; Region: PRK09375 717785007320 L-aspartate oxidase; Provisional; Region: PRK07512 717785007321 L-aspartate oxidase; Provisional; Region: PRK06175 717785007322 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 717785007323 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 717785007324 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 717785007325 dimerization interface [polypeptide binding]; other site 717785007326 active site 717785007327 pyruvate phosphate dikinase; Provisional; Region: PRK09279 717785007328 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 717785007329 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 717785007330 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 717785007331 hypothetical protein; Validated; Region: PRK09104 717785007332 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 717785007333 metal binding site [ion binding]; metal-binding site 717785007334 putative dimer interface [polypeptide binding]; other site 717785007335 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 717785007336 B1 nucleotide binding pocket [chemical binding]; other site 717785007337 B2 nucleotide binding pocket [chemical binding]; other site 717785007338 CAS motifs; other site 717785007339 active site 717785007340 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 717785007341 short chain dehydrogenase; Provisional; Region: PRK09134 717785007342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007343 NAD(P) binding site [chemical binding]; other site 717785007344 active site 717785007345 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 717785007346 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 717785007347 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 717785007348 GIY-YIG motif/motif A; other site 717785007349 active site 717785007350 catalytic site [active] 717785007351 putative DNA binding site [nucleotide binding]; other site 717785007352 metal binding site [ion binding]; metal-binding site 717785007353 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 717785007354 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 717785007355 Mechanosensitive ion channel; Region: MS_channel; pfam00924 717785007356 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 717785007357 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 717785007358 MoaE interaction surface [polypeptide binding]; other site 717785007359 MoeB interaction surface [polypeptide binding]; other site 717785007360 thiocarboxylated glycine; other site 717785007361 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 717785007362 MoaE homodimer interface [polypeptide binding]; other site 717785007363 MoaD interaction [polypeptide binding]; other site 717785007364 active site residues [active] 717785007365 AMIN domain; Region: AMIN; pfam11741 717785007366 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 717785007367 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717785007368 active site 717785007369 metal binding site [ion binding]; metal-binding site 717785007370 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 717785007371 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 717785007372 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 717785007373 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 717785007374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785007375 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 717785007376 DNA binding residues [nucleotide binding] 717785007377 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 717785007378 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785007379 RNA binding surface [nucleotide binding]; other site 717785007380 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 717785007381 active site 717785007382 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 717785007383 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785007384 Cupin domain; Region: Cupin_2; cl17218 717785007385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785007386 Carboxylesterase family; Region: COesterase; pfam00135 717785007387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 717785007388 substrate binding pocket [chemical binding]; other site 717785007389 catalytic triad [active] 717785007390 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 717785007391 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 717785007392 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785007393 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785007394 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 717785007395 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 717785007396 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 717785007397 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 717785007398 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717785007399 Walker A motif; other site 717785007400 ATP binding site [chemical binding]; other site 717785007401 Walker B motif; other site 717785007402 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 717785007403 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717785007404 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 717785007405 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 717785007406 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 717785007407 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 717785007408 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 717785007409 general secretion pathway protein J; Validated; Region: PRK08808 717785007410 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 717785007411 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 717785007412 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 717785007413 Carboxylesterase family; Region: COesterase; pfam00135 717785007414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 717785007415 substrate binding pocket [chemical binding]; other site 717785007416 catalytic triad [active] 717785007417 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785007418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785007419 Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807 717785007420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785007421 catalytic site [active] 717785007422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785007423 Carboxylesterase family; Region: COesterase; pfam00135 717785007424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 717785007425 substrate binding pocket [chemical binding]; other site 717785007426 catalytic triad [active] 717785007427 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 717785007428 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 717785007429 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 717785007430 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785007431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785007432 DNA-binding site [nucleotide binding]; DNA binding site 717785007433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785007434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785007435 homodimer interface [polypeptide binding]; other site 717785007436 catalytic residue [active] 717785007437 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 717785007438 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785007439 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 717785007440 putative active site [active] 717785007441 catalytic triad [active] 717785007442 putative dimer interface [polypeptide binding]; other site 717785007443 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 717785007444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785007445 FeS/SAM binding site; other site 717785007446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 717785007447 Coenzyme A binding pocket [chemical binding]; other site 717785007448 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 717785007449 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 717785007450 dimerization interface [polypeptide binding]; other site 717785007451 putative ATP binding site [chemical binding]; other site 717785007452 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 717785007453 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 717785007454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785007455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007457 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785007458 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785007459 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785007460 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785007461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785007464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785007465 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785007466 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 717785007467 conserved cys residue [active] 717785007468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785007469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717785007470 Zn2+ binding site [ion binding]; other site 717785007471 Mg2+ binding site [ion binding]; other site 717785007472 PAS domain S-box; Region: sensory_box; TIGR00229 717785007473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785007474 putative active site [active] 717785007475 heme pocket [chemical binding]; other site 717785007476 histidine kinase; Provisional; Region: PRK13557 717785007477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785007478 putative active site [active] 717785007479 heme pocket [chemical binding]; other site 717785007480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785007481 dimer interface [polypeptide binding]; other site 717785007482 phosphorylation site [posttranslational modification] 717785007483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007484 ATP binding site [chemical binding]; other site 717785007485 Mg2+ binding site [ion binding]; other site 717785007486 G-X-G motif; other site 717785007487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785007488 active site 717785007489 phosphorylation site [posttranslational modification] 717785007490 intermolecular recognition site; other site 717785007491 dimerization interface [polypeptide binding]; other site 717785007492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785007493 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785007494 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785007495 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 717785007496 Walker A/P-loop; other site 717785007497 ATP binding site [chemical binding]; other site 717785007498 Q-loop/lid; other site 717785007499 ABC transporter signature motif; other site 717785007500 Walker B; other site 717785007501 D-loop; other site 717785007502 H-loop/switch region; other site 717785007503 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785007504 Walker A/P-loop; other site 717785007505 ATP binding site [chemical binding]; other site 717785007506 Q-loop/lid; other site 717785007507 ABC transporter signature motif; other site 717785007508 Walker B; other site 717785007509 D-loop; other site 717785007510 H-loop/switch region; other site 717785007511 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717785007512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785007513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717785007514 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785007515 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717785007516 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007517 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785007518 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785007519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785007520 dimer interface [polypeptide binding]; other site 717785007521 conserved gate region; other site 717785007522 putative PBP binding loops; other site 717785007523 ABC-ATPase subunit interface; other site 717785007524 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007525 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007526 Walker A/P-loop; other site 717785007527 ATP binding site [chemical binding]; other site 717785007528 Q-loop/lid; other site 717785007529 ABC transporter signature motif; other site 717785007530 Walker B; other site 717785007531 D-loop; other site 717785007532 H-loop/switch region; other site 717785007533 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 717785007534 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785007535 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 717785007536 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 717785007537 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 717785007538 Creatinine amidohydrolase; Region: Creatininase; pfam02633 717785007539 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 717785007540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785007541 S-adenosylmethionine binding site [chemical binding]; other site 717785007542 Erythromycin esterase; Region: Erythro_esteras; pfam05139 717785007543 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785007544 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 717785007545 putative dimer interface [polypeptide binding]; other site 717785007546 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 717785007547 BON domain; Region: BON; pfam04972 717785007548 BON domain; Region: BON; pfam04972 717785007549 BON domain; Region: BON; pfam04972 717785007550 FOG: CBS domain [General function prediction only]; Region: COG0517 717785007551 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 717785007552 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 717785007553 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 717785007554 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 717785007555 30S subunit binding site; other site 717785007556 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 717785007557 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785007558 Ligand Binding Site [chemical binding]; other site 717785007559 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 717785007560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785007561 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 717785007562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785007563 motif II; other site 717785007564 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785007565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785007566 dimerization interface [polypeptide binding]; other site 717785007567 putative DNA binding site [nucleotide binding]; other site 717785007568 putative Zn2+ binding site [ion binding]; other site 717785007569 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 717785007570 Low molecular weight phosphatase family; Region: LMWPc; cd00115 717785007571 active site 717785007572 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 717785007573 Sodium Bile acid symporter family; Region: SBF; cl17470 717785007574 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 717785007575 ArsC family; Region: ArsC; pfam03960 717785007576 catalytic residues [active] 717785007577 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 717785007578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785007579 Cytochrome c; Region: Cytochrom_C; pfam00034 717785007580 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785007581 Sel1-like repeats; Region: SEL1; smart00671 717785007582 Sel1-like repeats; Region: SEL1; smart00671 717785007583 Sel1-like repeats; Region: SEL1; smart00671 717785007584 Sel1-like repeats; Region: SEL1; smart00671 717785007585 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 717785007586 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 717785007587 putative substrate binding site [chemical binding]; other site 717785007588 nucleotide binding site [chemical binding]; other site 717785007589 nucleotide binding site [chemical binding]; other site 717785007590 homodimer interface [polypeptide binding]; other site 717785007591 agmatine deiminase; Provisional; Region: PRK13551 717785007592 agmatine deiminase; Region: agmatine_aguA; TIGR03380 717785007593 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785007594 putrescine carbamoyltransferase; Provisional; Region: PRK02255 717785007595 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785007596 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785007597 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 717785007598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785007599 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 717785007600 putative active site [active] 717785007601 putative metal binding site [ion binding]; other site 717785007602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785007603 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785007604 Uncharacterized conserved protein [Function unknown]; Region: COG2353 717785007605 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 717785007606 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 717785007607 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785007608 catalytic loop [active] 717785007609 iron binding site [ion binding]; other site 717785007610 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 717785007611 FAD binding pocket [chemical binding]; other site 717785007612 FAD binding motif [chemical binding]; other site 717785007613 phosphate binding motif [ion binding]; other site 717785007614 beta-alpha-beta structure motif; other site 717785007615 NAD binding pocket [chemical binding]; other site 717785007616 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 717785007617 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 717785007618 Tetratricopeptide repeat; Region: TPR_2; pfam07719 717785007619 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 717785007620 active site 717785007621 phosphorylation site [posttranslational modification] 717785007622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785007624 active site 717785007625 phosphorylation site [posttranslational modification] 717785007626 intermolecular recognition site; other site 717785007627 dimerization interface [polypeptide binding]; other site 717785007628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785007629 DNA binding site [nucleotide binding] 717785007630 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 717785007631 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 717785007632 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 717785007633 Ligand Binding Site [chemical binding]; other site 717785007634 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 717785007635 GAF domain; Region: GAF_3; pfam13492 717785007636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785007637 dimer interface [polypeptide binding]; other site 717785007638 phosphorylation site [posttranslational modification] 717785007639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007640 ATP binding site [chemical binding]; other site 717785007641 Mg2+ binding site [ion binding]; other site 717785007642 G-X-G motif; other site 717785007643 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 717785007644 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 717785007645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785007646 Soluble P-type ATPase [General function prediction only]; Region: COG4087 717785007647 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 717785007648 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 717785007649 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 717785007650 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 717785007651 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 717785007652 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 717785007653 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785007654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785007655 active site 717785007656 phosphorylation site [posttranslational modification] 717785007657 intermolecular recognition site; other site 717785007658 dimerization interface [polypeptide binding]; other site 717785007659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785007660 DNA binding site [nucleotide binding] 717785007661 HAMP domain; Region: HAMP; pfam00672 717785007662 dimerization interface [polypeptide binding]; other site 717785007663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785007664 dimer interface [polypeptide binding]; other site 717785007665 phosphorylation site [posttranslational modification] 717785007666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007667 ATP binding site [chemical binding]; other site 717785007668 Mg2+ binding site [ion binding]; other site 717785007669 G-X-G motif; other site 717785007670 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 717785007671 Bacterial SH3 domain; Region: SH3_3; pfam08239 717785007672 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 717785007673 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785007674 NodB motif; other site 717785007675 active site 717785007676 catalytic site [active] 717785007677 metal binding site [ion binding]; metal-binding site 717785007678 SnoaL-like domain; Region: SnoaL_2; pfam12680 717785007679 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 717785007680 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 717785007681 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785007682 catalytic residues [active] 717785007683 glutamine synthetase; Region: PLN02284 717785007684 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 717785007685 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785007686 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 717785007687 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 717785007688 glutaminase; Provisional; Region: PRK00971 717785007689 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785007690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007691 NAD(P) binding site [chemical binding]; other site 717785007692 active site 717785007693 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785007694 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 717785007695 conserved cys residue [active] 717785007696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785007697 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 717785007698 Putative serine esterase (DUF676); Region: DUF676; pfam05057 717785007699 membrane ATPase/protein kinase; Provisional; Region: PRK09435 717785007700 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 717785007701 Walker A; other site 717785007702 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 717785007703 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785007704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007705 ligand binding site [chemical binding]; other site 717785007706 flexible hinge region; other site 717785007707 Bacterial sugar transferase; Region: Bac_transf; pfam02397 717785007708 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 717785007709 transcriptional activator RfaH; Region: RfaH; TIGR01955 717785007710 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 717785007711 heterodimer interface [polypeptide binding]; other site 717785007712 homodimer interface [polypeptide binding]; other site 717785007713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007714 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 717785007715 putative acyl transferase; Provisional; Region: PRK10502 717785007716 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 717785007717 putative trimer interface [polypeptide binding]; other site 717785007718 putative active site [active] 717785007719 putative substrate binding site [chemical binding]; other site 717785007720 putative CoA binding site [chemical binding]; other site 717785007721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007722 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 717785007723 putative ADP-binding pocket [chemical binding]; other site 717785007724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785007728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007732 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 717785007733 putative ADP-binding pocket [chemical binding]; other site 717785007734 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 717785007735 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785007736 HSP70 interaction site [polypeptide binding]; other site 717785007737 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785007738 Chain length determinant protein; Region: Wzz; pfam02706 717785007739 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 717785007740 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 717785007741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785007742 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785007743 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 717785007744 SLBB domain; Region: SLBB; pfam10531 717785007745 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 717785007746 O-Antigen ligase; Region: Wzy_C; pfam04932 717785007747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785007748 metal binding site [ion binding]; metal-binding site 717785007749 active site 717785007750 I-site; other site 717785007751 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785007752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785007753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785007754 DNA binding residues [nucleotide binding] 717785007755 dimerization interface [polypeptide binding]; other site 717785007756 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 717785007757 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 717785007758 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 717785007759 Autotransporter beta-domain; Region: Autotransporter; smart00869 717785007760 PilZ domain; Region: PilZ; cl01260 717785007761 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 717785007762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785007763 TPR motif; other site 717785007764 binding surface 717785007765 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 717785007766 active site 717785007767 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 717785007768 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785007769 Methyltransferase domain; Region: Methyltransf_12; pfam08242 717785007770 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 717785007771 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717785007772 extended (e) SDRs; Region: SDR_e; cd08946 717785007773 NAD(P) binding site [chemical binding]; other site 717785007774 active site 717785007775 substrate binding site [chemical binding]; other site 717785007776 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 717785007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785007778 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 717785007779 putative dimerization interface [polypeptide binding]; other site 717785007780 Predicted membrane protein [Function unknown]; Region: COG2855 717785007781 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 717785007782 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 717785007783 envelope glycoprotein I; Provisional; Region: PHA03291 717785007784 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 717785007785 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 717785007786 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 717785007787 active site 717785007788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 717785007789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785007790 Response regulator receiver domain; Region: Response_reg; pfam00072 717785007791 active site 717785007792 phosphorylation site [posttranslational modification] 717785007793 intermolecular recognition site; other site 717785007794 dimerization interface [polypeptide binding]; other site 717785007795 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785007796 DNA-binding site [nucleotide binding]; DNA binding site 717785007797 RNA-binding motif; other site 717785007798 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 717785007799 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 717785007800 GTP-binding protein Der; Reviewed; Region: PRK00093 717785007801 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 717785007802 G1 box; other site 717785007803 GTP/Mg2+ binding site [chemical binding]; other site 717785007804 Switch I region; other site 717785007805 G2 box; other site 717785007806 Switch II region; other site 717785007807 G3 box; other site 717785007808 G4 box; other site 717785007809 G5 box; other site 717785007810 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 717785007811 G1 box; other site 717785007812 GTP/Mg2+ binding site [chemical binding]; other site 717785007813 Switch I region; other site 717785007814 G2 box; other site 717785007815 G3 box; other site 717785007816 Switch II region; other site 717785007817 G4 box; other site 717785007818 G5 box; other site 717785007819 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 717785007820 Trp docking motif [polypeptide binding]; other site 717785007821 active site 717785007822 PQQ-like domain; Region: PQQ_2; pfam13360 717785007823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 717785007824 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 717785007825 oligomerization interface [polypeptide binding]; other site 717785007826 active site 717785007827 metal binding site [ion binding]; metal-binding site 717785007828 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785007829 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 717785007830 BNR repeat-like domain; Region: BNR_2; pfam13088 717785007831 NnrU protein; Region: NnrU; pfam07298 717785007832 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 717785007833 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717785007834 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 717785007835 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 717785007836 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 717785007837 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 717785007838 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785007839 Predicted transcriptional regulators [Transcription]; Region: COG1733 717785007840 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 717785007841 peptide chain release factor 2; Provisional; Region: PRK07342 717785007842 This domain is found in peptide chain release factors; Region: PCRF; smart00937 717785007843 RF-1 domain; Region: RF-1; pfam00472 717785007844 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 717785007845 Transglycosylase; Region: Transgly; pfam00912 717785007846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 717785007847 AMIN domain; Region: AMIN; pfam11741 717785007848 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 717785007849 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717785007850 active site 717785007851 metal binding site [ion binding]; metal-binding site 717785007852 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 717785007853 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 717785007854 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 717785007855 Peptidase family M48; Region: Peptidase_M48; cl12018 717785007856 TPR repeat; Region: TPR_11; pfam13414 717785007857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785007858 TPR motif; other site 717785007859 binding surface 717785007860 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 717785007861 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 717785007862 catalytic residues [active] 717785007863 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 717785007864 Dehydroquinase class II; Region: DHquinase_II; pfam01220 717785007865 trimer interface [polypeptide binding]; other site 717785007866 active site 717785007867 dimer interface [polypeptide binding]; other site 717785007868 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 717785007869 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 717785007870 carboxyltransferase (CT) interaction site; other site 717785007871 biotinylation site [posttranslational modification]; other site 717785007872 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 717785007873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785007874 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 717785007875 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 717785007876 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 717785007877 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 717785007878 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 717785007879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007880 D-galactonate transporter; Region: 2A0114; TIGR00893 717785007881 putative substrate translocation pore; other site 717785007882 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785007883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007887 short chain dehydrogenase; Provisional; Region: PRK06180 717785007888 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785007889 NADP binding site [chemical binding]; other site 717785007890 active site 717785007891 steroid binding site; other site 717785007892 GMP synthase; Reviewed; Region: guaA; PRK00074 717785007893 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 717785007894 AMP/PPi binding site [chemical binding]; other site 717785007895 candidate oxyanion hole; other site 717785007896 catalytic triad [active] 717785007897 potential glutamine specificity residues [chemical binding]; other site 717785007898 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 717785007899 ATP Binding subdomain [chemical binding]; other site 717785007900 Ligand Binding sites [chemical binding]; other site 717785007901 Dimerization subdomain; other site 717785007902 TspO/MBR family; Region: TspO_MBR; pfam03073 717785007903 SET domain; Region: SET; pfam00856 717785007904 SET domain; Region: SET; pfam00856 717785007905 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 717785007906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785007907 MAPEG family; Region: MAPEG; cl09190 717785007908 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 717785007909 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 717785007910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 717785007911 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 717785007912 active site 717785007913 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 717785007914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785007915 S-adenosylmethionine binding site [chemical binding]; other site 717785007916 exopolyphosphatase; Region: exo_poly_only; TIGR03706 717785007917 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 717785007918 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 717785007919 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785007920 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785007921 catalytic residues [active] 717785007922 catalytic nucleophile [active] 717785007923 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785007924 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785007925 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785007926 Synaptic Site I dimer interface [polypeptide binding]; other site 717785007927 DNA binding site [nucleotide binding] 717785007928 Recombinase; Region: Recombinase; pfam07508 717785007929 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785007930 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785007931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 717785007932 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785007933 Transposase domain (DUF772); Region: DUF772; pfam05598 717785007934 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785007935 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785007936 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785007937 Walker A/P-loop; other site 717785007938 ATP binding site [chemical binding]; other site 717785007939 Q-loop/lid; other site 717785007940 ABC transporter signature motif; other site 717785007941 Walker B; other site 717785007942 D-loop; other site 717785007943 H-loop/switch region; other site 717785007944 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785007945 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 717785007946 FtsX-like permease family; Region: FtsX; pfam02687 717785007947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785007948 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785007949 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785007950 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 717785007951 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785007952 Ligand Binding Site [chemical binding]; other site 717785007953 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 717785007954 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 717785007955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785007956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785007957 motif II; other site 717785007958 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785007959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785007960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785007961 DNA binding site [nucleotide binding] 717785007962 Predicted integral membrane protein [Function unknown]; Region: COG5616 717785007963 TPR repeat; Region: TPR_11; pfam13414 717785007964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785007965 TPR motif; other site 717785007966 TPR repeat; Region: TPR_11; pfam13414 717785007967 binding surface 717785007968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785007969 binding surface 717785007970 TPR motif; other site 717785007971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007972 NADH(P)-binding; Region: NAD_binding_10; pfam13460 717785007973 NAD(P) binding site [chemical binding]; other site 717785007974 active site 717785007975 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785007976 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785007977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785007978 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785007979 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007980 ligand binding site [chemical binding]; other site 717785007981 flexible hinge region; other site 717785007982 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 717785007983 putative switch regulator; other site 717785007984 non-specific DNA interactions [nucleotide binding]; other site 717785007985 DNA binding site [nucleotide binding] 717785007986 sequence specific DNA binding site [nucleotide binding]; other site 717785007987 putative cAMP binding site [chemical binding]; other site 717785007988 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 717785007989 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007990 ligand binding site [chemical binding]; other site 717785007991 flexible hinge region; other site 717785007992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785007993 putative switch regulator; other site 717785007994 non-specific DNA interactions [nucleotide binding]; other site 717785007995 DNA binding site [nucleotide binding] 717785007996 sequence specific DNA binding site [nucleotide binding]; other site 717785007997 putative cAMP binding site [chemical binding]; other site 717785007998 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 717785007999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008000 putative substrate translocation pore; other site 717785008001 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 717785008002 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 717785008003 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 717785008004 [4Fe-4S] binding site [ion binding]; other site 717785008005 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 717785008006 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 717785008007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 717785008008 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 717785008009 molybdopterin cofactor binding site; other site 717785008010 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 717785008011 4Fe-4S binding domain; Region: Fer4; cl02805 717785008012 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 717785008013 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 717785008014 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 717785008015 Predicted integral membrane protein [Function unknown]; Region: COG5615 717785008016 NnrS protein; Region: NnrS; pfam05940 717785008017 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785008018 Transposase domain (DUF772); Region: DUF772; pfam05598 717785008019 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 717785008020 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 717785008021 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785008022 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 717785008023 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785008024 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 717785008025 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 717785008026 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 717785008027 Response regulator receiver domain; Region: Response_reg; pfam00072 717785008028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008029 active site 717785008030 phosphorylation site [posttranslational modification] 717785008031 intermolecular recognition site; other site 717785008032 H-NS histone family; Region: Histone_HNS; pfam00816 717785008033 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 717785008034 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 717785008035 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 717785008036 HD domain; Region: HD_4; pfam13328 717785008037 Helix-turn-helix domain; Region: HTH_17; pfam12728 717785008038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785008039 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785008040 ligand binding site [chemical binding]; other site 717785008041 flexible hinge region; other site 717785008042 Sulfatase; Region: Sulfatase; cl17466 717785008043 Helix-turn-helix domain; Region: HTH_28; pfam13518 717785008044 Winged helix-turn helix; Region: HTH_29; pfam13551 717785008045 Homeodomain-like domain; Region: HTH_32; pfam13565 717785008046 Integrase core domain; Region: rve; pfam00665 717785008047 Integrase core domain; Region: rve_3; pfam13683 717785008048 Transposase; Region: HTH_Tnp_1; cl17663 717785008049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 717785008050 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785008051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785008052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 717785008053 DNA binding residues [nucleotide binding] 717785008054 short chain dehydrogenase; Provisional; Region: PRK07024 717785008055 classical (c) SDRs; Region: SDR_c; cd05233 717785008056 NAD(P) binding site [chemical binding]; other site 717785008057 active site 717785008058 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785008059 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 717785008060 putative NADP binding site [chemical binding]; other site 717785008061 putative substrate binding site [chemical binding]; other site 717785008062 active site 717785008063 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 717785008064 B12 binding site [chemical binding]; other site 717785008065 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 717785008066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785008067 FeS/SAM binding site; other site 717785008068 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 717785008069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785008070 PAS domain S-box; Region: sensory_box; TIGR00229 717785008071 putative active site [active] 717785008072 heme pocket [chemical binding]; other site 717785008073 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785008074 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 717785008075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785008076 S-adenosylmethionine binding site [chemical binding]; other site 717785008077 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 717785008078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 717785008079 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 717785008080 CheB methylesterase; Region: CheB_methylest; pfam01339 717785008081 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 717785008082 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785008083 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 717785008084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 717785008085 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785008086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785008087 dimer interface [polypeptide binding]; other site 717785008088 phosphorylation site [posttranslational modification] 717785008089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008090 ATP binding site [chemical binding]; other site 717785008091 Mg2+ binding site [ion binding]; other site 717785008092 G-X-G motif; other site 717785008093 Response regulator receiver domain; Region: Response_reg; pfam00072 717785008094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008095 active site 717785008096 phosphorylation site [posttranslational modification] 717785008097 intermolecular recognition site; other site 717785008098 dimerization interface [polypeptide binding]; other site 717785008099 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 717785008100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008101 active site 717785008102 phosphorylation site [posttranslational modification] 717785008103 intermolecular recognition site; other site 717785008104 dimerization interface [polypeptide binding]; other site 717785008105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785008106 DNA binding residues [nucleotide binding] 717785008107 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785008108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008109 active site 717785008110 phosphorylation site [posttranslational modification] 717785008111 intermolecular recognition site; other site 717785008112 dimerization interface [polypeptide binding]; other site 717785008113 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785008114 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 717785008115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785008116 DNA-binding site [nucleotide binding]; DNA binding site 717785008117 RNA-binding motif; other site 717785008118 Haemolysin-III related; Region: HlyIII; cl03831 717785008119 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785008120 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785008121 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785008122 Protein required for attachment to host cells; Region: Host_attach; pfam10116 717785008123 Low affinity iron permease; Region: Iron_permease; cl12096 717785008124 Low affinity iron permease; Region: Iron_permease; cl12096 717785008125 Helix-turn-helix domain; Region: HTH_28; pfam13518 717785008126 Winged helix-turn helix; Region: HTH_29; pfam13551 717785008127 Homeodomain-like domain; Region: HTH_32; pfam13565 717785008128 Integrase core domain; Region: rve; pfam00665 717785008129 Integrase core domain; Region: rve_3; pfam13683 717785008130 Transposase; Region: HTH_Tnp_1; cl17663 717785008131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 717785008132 Protein required for attachment to host cells; Region: Host_attach; pfam10116 717785008133 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785008134 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785008135 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785008136 Transposase; Region: HTH_Tnp_1; cl17663 717785008137 HTH-like domain; Region: HTH_21; pfam13276 717785008138 Integrase core domain; Region: rve; pfam00665 717785008139 Integrase core domain; Region: rve_3; pfam13683 717785008140 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 717785008141 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 717785008142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785008143 Terminase-like family; Region: Terminase_6; pfam03237 717785008144 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785008145 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717785008146 ParB-like nuclease domain; Region: ParBc; pfam02195 717785008147 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785008148 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785008149 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785008150 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785008151 catalytic residues [active] 717785008152 catalytic nucleophile [active] 717785008153 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785008154 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785008155 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785008156 Synaptic Site I dimer interface [polypeptide binding]; other site 717785008157 DNA binding site [nucleotide binding] 717785008158 Recombinase; Region: Recombinase; pfam07508 717785008159 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717785008160 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785008161 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785008162 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785008163 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 717785008164 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 717785008165 putative active site [active] 717785008166 putative metal-binding site [ion binding]; other site 717785008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 717785008168 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 717785008169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785008170 active site 717785008171 ATP binding site [chemical binding]; other site 717785008172 substrate binding site [chemical binding]; other site 717785008173 activation loop (A-loop); other site 717785008174 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 717785008175 AAA domain; Region: AAA_11; pfam13086 717785008176 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 717785008177 AAA domain; Region: AAA_12; pfam13087 717785008178 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 717785008179 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 717785008180 Zeta toxin; Region: Zeta_toxin; pfam06414 717785008181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785008182 Walker A motif; other site 717785008183 ATP binding site [chemical binding]; other site 717785008184 Walker B motif; other site 717785008185 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 717785008186 enoyl-CoA hydratase; Provisional; Region: PRK06688 717785008187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785008188 substrate binding site [chemical binding]; other site 717785008189 oxyanion hole (OAH) forming residues; other site 717785008190 trimer interface [polypeptide binding]; other site 717785008191 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 717785008192 Phenylacetic acid degradation B; Region: PaaB; cl01371 717785008193 Domain of unknown function DUF59; Region: DUF59; cl00941 717785008194 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 717785008195 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 717785008196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785008197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785008199 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785008200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785008201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785008202 acyl-activating enzyme (AAE) consensus motif; other site 717785008203 acyl-activating enzyme (AAE) consensus motif; other site 717785008204 AMP binding site [chemical binding]; other site 717785008205 active site 717785008206 CoA binding site [chemical binding]; other site 717785008207 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 717785008208 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 717785008209 DctM-like transporters; Region: DctM; pfam06808 717785008210 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 717785008211 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 717785008212 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 717785008213 Flavoprotein; Region: Flavoprotein; pfam02441 717785008214 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 717785008215 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 717785008216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785008217 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 717785008218 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 717785008219 Walker A/P-loop; other site 717785008220 ATP binding site [chemical binding]; other site 717785008221 Q-loop/lid; other site 717785008222 ABC transporter signature motif; other site 717785008223 Walker B; other site 717785008224 D-loop; other site 717785008225 H-loop/switch region; other site 717785008226 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 717785008227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785008228 Walker A/P-loop; other site 717785008229 ATP binding site [chemical binding]; other site 717785008230 Q-loop/lid; other site 717785008231 ABC transporter signature motif; other site 717785008232 Walker B; other site 717785008233 D-loop; other site 717785008234 H-loop/switch region; other site 717785008235 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785008236 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 717785008237 TM-ABC transporter signature motif; other site 717785008238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717785008239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785008240 TM-ABC transporter signature motif; other site 717785008241 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785008242 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785008243 ligand binding site [chemical binding]; other site 717785008244 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 717785008245 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 717785008246 NAD binding site [chemical binding]; other site 717785008247 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785008248 Transcriptional regulator; Region: Rrf2; pfam02082 717785008249 enoyl-CoA hydratase; Provisional; Region: PRK08290 717785008250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 717785008251 substrate binding site [chemical binding]; other site 717785008252 oxyanion hole (OAH) forming residues; other site 717785008253 trimer interface [polypeptide binding]; other site 717785008254 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785008255 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785008256 active site 717785008257 non-prolyl cis peptide bond; other site 717785008258 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785008259 active site 717785008260 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785008261 dimer interface [polypeptide binding]; other site 717785008262 non-prolyl cis peptide bond; other site 717785008263 insertion regions; other site 717785008264 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785008265 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785008266 dimer interface [polypeptide binding]; other site 717785008267 catalytic residue [active] 717785008268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008269 putative substrate translocation pore; other site 717785008270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785008271 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 717785008272 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785008273 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 717785008274 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785008275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785008276 substrate binding pocket [chemical binding]; other site 717785008277 membrane-bound complex binding site; other site 717785008278 hinge residues; other site 717785008279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 717785008280 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785008281 dimer interface [polypeptide binding]; other site 717785008282 conserved gate region; other site 717785008283 putative PBP binding loops; other site 717785008284 ABC-ATPase subunit interface; other site 717785008285 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008286 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008287 Walker A/P-loop; other site 717785008288 ATP binding site [chemical binding]; other site 717785008289 Q-loop/lid; other site 717785008290 ABC transporter signature motif; other site 717785008291 Walker B; other site 717785008292 D-loop; other site 717785008293 H-loop/switch region; other site 717785008294 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785008295 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 717785008296 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785008297 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785008298 active site 717785008299 non-prolyl cis peptide bond; other site 717785008300 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785008301 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 717785008302 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717785008303 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717785008304 PhoU domain; Region: PhoU; pfam01895 717785008305 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008306 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008307 Walker A/P-loop; other site 717785008308 ATP binding site [chemical binding]; other site 717785008309 Q-loop/lid; other site 717785008310 ABC transporter signature motif; other site 717785008311 Walker B; other site 717785008312 D-loop; other site 717785008313 H-loop/switch region; other site 717785008314 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785008315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008316 dimer interface [polypeptide binding]; other site 717785008317 conserved gate region; other site 717785008318 putative PBP binding loops; other site 717785008319 ABC-ATPase subunit interface; other site 717785008320 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785008321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785008322 substrate binding pocket [chemical binding]; other site 717785008323 membrane-bound complex binding site; other site 717785008324 hinge residues; other site 717785008325 Uncharacterized conserved protein [Function unknown]; Region: COG1262 717785008326 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 717785008327 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785008328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785008329 substrate binding pocket [chemical binding]; other site 717785008330 membrane-bound complex binding site; other site 717785008331 hinge residues; other site 717785008332 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785008333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785008334 substrate binding pocket [chemical binding]; other site 717785008335 membrane-bound complex binding site; other site 717785008336 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 717785008337 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785008338 active site 717785008339 dimer interface [polypeptide binding]; other site 717785008340 non-prolyl cis peptide bond; other site 717785008341 insertion regions; other site 717785008342 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785008343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008344 dimer interface [polypeptide binding]; other site 717785008345 conserved gate region; other site 717785008346 putative PBP binding loops; other site 717785008347 ABC-ATPase subunit interface; other site 717785008348 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008349 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008350 Walker A/P-loop; other site 717785008351 ATP binding site [chemical binding]; other site 717785008352 Q-loop/lid; other site 717785008353 ABC transporter signature motif; other site 717785008354 Walker B; other site 717785008355 D-loop; other site 717785008356 H-loop/switch region; other site 717785008357 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785008358 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785008359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785008360 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 717785008361 substrate binding site [chemical binding]; other site 717785008362 dimerization interface [polypeptide binding]; other site 717785008363 HEAT repeats; Region: HEAT_2; pfam13646 717785008364 HEAT repeats; Region: HEAT_2; pfam13646 717785008365 HEAT repeats; Region: HEAT_2; pfam13646 717785008366 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 717785008367 putative oxidoreductase; Provisional; Region: PRK08275 717785008368 L-aspartate oxidase; Provisional; Region: PRK06175 717785008369 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 717785008370 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008371 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008372 Walker A/P-loop; other site 717785008373 ATP binding site [chemical binding]; other site 717785008374 Q-loop/lid; other site 717785008375 ABC transporter signature motif; other site 717785008376 Walker B; other site 717785008377 D-loop; other site 717785008378 H-loop/switch region; other site 717785008379 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785008380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008381 putative PBP binding loops; other site 717785008382 dimer interface [polypeptide binding]; other site 717785008383 ABC-ATPase subunit interface; other site 717785008384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 717785008385 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785008386 substrate binding pocket [chemical binding]; other site 717785008387 membrane-bound complex binding site; other site 717785008388 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717785008389 ParB-like nuclease domain; Region: ParBc; pfam02195 717785008390 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785008391 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785008392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785008393 Terminase-like family; Region: Terminase_6; pfam03237 717785008394 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785008395 Homeodomain-like domain; Region: HTH_32; pfam13565 717785008396 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 717785008397 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785008398 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785008399 catalytic residues [active] 717785008400 catalytic nucleophile [active] 717785008401 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785008402 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785008403 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785008404 Synaptic Site I dimer interface [polypeptide binding]; other site 717785008405 DNA binding site [nucleotide binding] 717785008406 Recombinase; Region: Recombinase; pfam07508 717785008407 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 717785008408 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785008409 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785008410 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 717785008411 sulfate transport protein; Provisional; Region: cysT; CHL00187 717785008412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008413 dimer interface [polypeptide binding]; other site 717785008414 conserved gate region; other site 717785008415 putative PBP binding loops; other site 717785008416 ABC-ATPase subunit interface; other site 717785008417 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785008418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008419 dimer interface [polypeptide binding]; other site 717785008420 conserved gate region; other site 717785008421 putative PBP binding loops; other site 717785008422 ABC-ATPase subunit interface; other site 717785008423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785008424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785008425 Walker A/P-loop; other site 717785008426 ATP binding site [chemical binding]; other site 717785008427 Q-loop/lid; other site 717785008428 ABC transporter signature motif; other site 717785008429 Walker B; other site 717785008430 D-loop; other site 717785008431 H-loop/switch region; other site 717785008432 TOBE domain; Region: TOBE_2; pfam08402 717785008433 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 717785008434 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785008435 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 717785008436 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785008437 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785008438 [2Fe-2S] cluster binding site [ion binding]; other site 717785008439 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 717785008440 putative alpha subunit interface [polypeptide binding]; other site 717785008441 putative active site [active] 717785008442 putative substrate binding site [chemical binding]; other site 717785008443 Fe binding site [ion binding]; other site 717785008444 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785008445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785008446 non-specific DNA binding site [nucleotide binding]; other site 717785008447 salt bridge; other site 717785008448 sequence-specific DNA binding site [nucleotide binding]; other site 717785008449 Cupin domain; Region: Cupin_2; pfam07883 717785008450 transcriptional regulator BetI; Validated; Region: PRK00767 717785008451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008452 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 717785008453 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 717785008454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785008455 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785008456 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 717785008457 FMN-binding pocket [chemical binding]; other site 717785008458 flavin binding motif; other site 717785008459 phosphate binding motif [ion binding]; other site 717785008460 beta-alpha-beta structure motif; other site 717785008461 NAD binding pocket [chemical binding]; other site 717785008462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785008463 catalytic loop [active] 717785008464 iron binding site [ion binding]; other site 717785008465 transcriptional regulator BetI; Validated; Region: PRK00767 717785008466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008467 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 717785008468 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 717785008469 CoA-transferase family III; Region: CoA_transf_3; pfam02515 717785008470 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 717785008471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785008472 FAD binding site [chemical binding]; other site 717785008473 substrate binding pocket [chemical binding]; other site 717785008474 catalytic base [active] 717785008475 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 717785008476 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 717785008477 Integrase core domain; Region: rve; pfam00665 717785008478 Autotransporter beta-domain; Region: Autotransporter; pfam03797 717785008479 Transposase; Region: HTH_Tnp_1; pfam01527 717785008480 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 717785008481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785008482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008483 dimerization interface [polypeptide binding]; other site 717785008484 citrate-proton symporter; Provisional; Region: PRK15075 717785008485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008486 putative substrate translocation pore; other site 717785008487 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785008488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785008489 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 717785008490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785008491 SopA-like catalytic domain; Region: SopA_C; pfam13979 717785008492 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785008493 active site 717785008494 ATP binding site [chemical binding]; other site 717785008495 substrate binding site [chemical binding]; other site 717785008496 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 717785008497 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 717785008498 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 717785008499 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 717785008500 type III secretion system protein YscR; Provisional; Region: PRK12797 717785008501 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 717785008502 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 717785008503 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 717785008504 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 717785008505 type III secretion system ATPase; Provisional; Region: PRK06936 717785008506 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785008507 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 717785008508 Walker A motif/ATP binding site; other site 717785008509 Walker B motif; other site 717785008510 Tir chaperone protein (CesT) family; Region: CesT; cl08444 717785008511 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 717785008512 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 717785008513 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 717785008514 ATP binding site [chemical binding]; other site 717785008515 Mg2+ binding site [ion binding]; other site 717785008516 G-X-G motif; other site 717785008517 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 717785008518 Cache domain; Region: Cache_1; pfam02743 717785008519 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 717785008520 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 717785008521 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 717785008522 anti sigma factor interaction site; other site 717785008523 regulatory phosphorylation site [posttranslational modification]; other site 717785008524 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 717785008525 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 717785008526 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 717785008527 Protein of unknown function (DUF917); Region: DUF917; pfam06032 717785008528 CAAX protease self-immunity; Region: Abi; pfam02517 717785008529 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785008530 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 717785008531 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 717785008532 Type III secretion needle MxiH like; Region: MxiH; cl09641 717785008533 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 717785008534 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 717785008535 FHIPEP family; Region: FHIPEP; pfam00771 717785008536 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 717785008537 HrpJ-like domain; Region: HrpJ; cl15454 717785008538 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 717785008539 Flagellar assembly protein FliH; Region: FliH; pfam02108 717785008540 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 717785008541 Type III secretion needle MxiH like; Region: MxiH; pfam09392 717785008542 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 717785008543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785008544 binding surface 717785008545 TPR motif; other site 717785008546 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 717785008547 type II secretion system protein D; Region: type_II_gspD; TIGR02517 717785008548 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785008549 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785008550 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 717785008551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785008552 Terminase-like family; Region: Terminase_6; pfam03237 717785008553 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785008554 ParB-like nuclease domain; Region: ParB; smart00470 717785008555 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717785008556 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785008557 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785008558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785008559 S-adenosylmethionine binding site [chemical binding]; other site 717785008560 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 717785008561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785008562 PAS domain; Region: PAS_9; pfam13426 717785008563 putative active site [active] 717785008564 heme pocket [chemical binding]; other site 717785008565 PAS fold; Region: PAS_4; pfam08448 717785008566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 717785008567 putative active site [active] 717785008568 heme pocket [chemical binding]; other site 717785008569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785008570 Histidine kinase; Region: HisKA_2; pfam07568 717785008571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008572 ATP binding site [chemical binding]; other site 717785008573 Mg2+ binding site [ion binding]; other site 717785008574 G-X-G motif; other site 717785008575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785008576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008577 active site 717785008578 phosphorylation site [posttranslational modification] 717785008579 intermolecular recognition site; other site 717785008580 dimerization interface [polypeptide binding]; other site 717785008581 PRC-barrel domain; Region: PRC; pfam05239 717785008582 PRC-barrel domain; Region: PRC; pfam05239 717785008583 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 717785008584 GAF domain; Region: GAF; pfam01590 717785008585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785008586 Histidine kinase; Region: HisKA_2; pfam07568 717785008587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008588 ATP binding site [chemical binding]; other site 717785008589 Mg2+ binding site [ion binding]; other site 717785008590 G-X-G motif; other site 717785008591 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785008592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008593 putative substrate translocation pore; other site 717785008594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008595 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 717785008596 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785008597 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785008598 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 717785008599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785008600 catalytic loop [active] 717785008601 iron binding site [ion binding]; other site 717785008602 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785008603 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785008604 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 717785008605 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785008606 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 717785008607 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785008608 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 717785008609 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 717785008610 classical (c) SDRs; Region: SDR_c; cd05233 717785008611 NAD(P) binding site [chemical binding]; other site 717785008612 active site 717785008613 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 717785008614 active site 717785008615 DNA polymerase IV; Validated; Region: PRK02406 717785008616 DNA binding site [nucleotide binding] 717785008617 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785008618 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 717785008619 FMN-binding pocket [chemical binding]; other site 717785008620 flavin binding motif; other site 717785008621 phosphate binding motif [ion binding]; other site 717785008622 beta-alpha-beta structure motif; other site 717785008623 NAD binding pocket [chemical binding]; other site 717785008624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785008625 catalytic loop [active] 717785008626 iron binding site [ion binding]; other site 717785008627 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785008628 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785008629 [2Fe-2S] cluster binding site [ion binding]; other site 717785008630 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 717785008631 hydrophobic ligand binding site; other site 717785008632 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785008633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785008634 DNA-binding site [nucleotide binding]; DNA binding site 717785008635 FCD domain; Region: FCD; pfam07729 717785008636 Isochorismatase family; Region: Isochorismatase; pfam00857 717785008637 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785008638 catalytic triad [active] 717785008639 conserved cis-peptide bond; other site 717785008640 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008641 Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150 717785008642 NAD(P) binding site [chemical binding]; other site 717785008643 catalytic residues [active] 717785008644 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 717785008645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785008646 catalytic residue [active] 717785008647 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 717785008648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785008649 DNA-binding site [nucleotide binding]; DNA binding site 717785008650 UTRA domain; Region: UTRA; cl17743 717785008651 acetylornithine deacetylase; Validated; Region: PRK06915 717785008652 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 717785008653 metal binding site [ion binding]; metal-binding site 717785008654 dimer interface [polypeptide binding]; other site 717785008655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785008656 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 717785008657 Coenzyme A transferase; Region: CoA_trans; cl17247 717785008658 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 717785008659 FO synthase; Reviewed; Region: fbiC; PRK09234 717785008660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785008661 FeS/SAM binding site; other site 717785008662 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 717785008663 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 717785008664 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 717785008665 dimer interface [polypeptide binding]; other site 717785008666 substrate binding site [chemical binding]; other site 717785008667 phosphate binding site [ion binding]; other site 717785008668 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 717785008669 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 717785008670 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 717785008671 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 717785008672 choline dehydrogenase; Validated; Region: PRK02106 717785008673 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785008674 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008675 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008676 Walker A/P-loop; other site 717785008677 ATP binding site [chemical binding]; other site 717785008678 Q-loop/lid; other site 717785008679 ABC transporter signature motif; other site 717785008680 Walker B; other site 717785008681 D-loop; other site 717785008682 H-loop/switch region; other site 717785008683 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785008684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008685 dimer interface [polypeptide binding]; other site 717785008686 conserved gate region; other site 717785008687 putative PBP binding loops; other site 717785008688 ABC-ATPase subunit interface; other site 717785008689 NMT1-like family; Region: NMT1_2; pfam13379 717785008690 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785008691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785008692 Terminase-like family; Region: Terminase_6; pfam03237 717785008693 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785008694 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785008695 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785008696 ParB-like nuclease domain; Region: ParBc; pfam02195 717785008697 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717785008698 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 717785008699 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785008700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785008701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008702 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 717785008703 dimer interface [polypeptide binding]; other site 717785008704 [2Fe-2S] cluster binding site [ion binding]; other site 717785008705 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785008706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785008707 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 717785008708 Tubulin like; Region: Tubulin_2; pfam13809 717785008709 Pleckstrin homology-like domain; Region: PH-like; cl17171 717785008710 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 717785008711 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 717785008712 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 717785008713 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 717785008714 multimer interface [polypeptide binding]; other site 717785008715 active site 717785008716 catalytic triad [active] 717785008717 dimer interface [polypeptide binding]; other site 717785008718 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785008719 metal ion-dependent adhesion site (MIDAS); other site 717785008720 MoxR-like ATPases [General function prediction only]; Region: COG0714 717785008721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785008722 Walker A motif; other site 717785008723 ATP binding site [chemical binding]; other site 717785008724 Walker B motif; other site 717785008725 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 717785008726 ANTAR domain; Region: ANTAR; pfam03861 717785008727 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785008728 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 717785008729 ligand binding site [chemical binding]; other site 717785008730 regulator interaction site; other site 717785008731 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 717785008732 putative active site [active] 717785008733 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785008734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008735 active site 717785008736 phosphorylation site [posttranslational modification] 717785008737 intermolecular recognition site; other site 717785008738 dimerization interface [polypeptide binding]; other site 717785008739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785008740 DNA binding site [nucleotide binding] 717785008741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785008742 HAMP domain; Region: HAMP; pfam00672 717785008743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008744 ATP binding site [chemical binding]; other site 717785008745 Mg2+ binding site [ion binding]; other site 717785008746 G-X-G motif; other site 717785008747 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 717785008748 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785008749 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 717785008750 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785008751 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785008752 N-terminal plug; other site 717785008753 ligand-binding site [chemical binding]; other site 717785008754 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 717785008755 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 717785008756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785008757 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 717785008758 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 717785008759 active site 717785008760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785008761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785008762 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785008763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785008764 non-specific DNA binding site [nucleotide binding]; other site 717785008765 salt bridge; other site 717785008766 sequence-specific DNA binding site [nucleotide binding]; other site 717785008767 Cupin domain; Region: Cupin_2; pfam07883 717785008768 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785008769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785008770 non-specific DNA binding site [nucleotide binding]; other site 717785008771 salt bridge; other site 717785008772 sequence-specific DNA binding site [nucleotide binding]; other site 717785008773 Cupin domain; Region: Cupin_2; pfam07883 717785008774 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008775 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785008776 NAD(P) binding site [chemical binding]; other site 717785008777 catalytic residues [active] 717785008778 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 717785008779 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785008780 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785008781 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785008782 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785008783 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785008784 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785008785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008787 dimer interface [polypeptide binding]; other site 717785008788 conserved gate region; other site 717785008789 putative PBP binding loops; other site 717785008790 ABC-ATPase subunit interface; other site 717785008791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785008792 dimer interface [polypeptide binding]; other site 717785008793 conserved gate region; other site 717785008794 putative PBP binding loops; other site 717785008795 ABC-ATPase subunit interface; other site 717785008796 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785008797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785008798 Walker A/P-loop; other site 717785008799 ATP binding site [chemical binding]; other site 717785008800 Q-loop/lid; other site 717785008801 ABC transporter signature motif; other site 717785008802 Walker B; other site 717785008803 D-loop; other site 717785008804 H-loop/switch region; other site 717785008805 TOBE domain; Region: TOBE_2; pfam08402 717785008806 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717785008807 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 717785008808 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 717785008809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008810 D-galactonate transporter; Region: 2A0114; TIGR00893 717785008811 putative substrate translocation pore; other site 717785008812 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 717785008813 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 717785008814 AsnC family; Region: AsnC_trans_reg; pfam01037 717785008815 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785008816 AsnC family; Region: AsnC_trans_reg; pfam01037 717785008817 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785008818 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 717785008819 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 717785008820 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 717785008821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 717785008822 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 717785008823 active site 717785008824 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 717785008825 EthD domain; Region: EthD; cl17553 717785008826 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785008827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008828 NAD(P) binding site [chemical binding]; other site 717785008829 catalytic residues [active] 717785008830 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785008831 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 717785008832 Trp docking motif [polypeptide binding]; other site 717785008833 dimer interface [polypeptide binding]; other site 717785008834 active site 717785008835 small subunit binding site [polypeptide binding]; other site 717785008836 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 717785008837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 717785008838 substrate binding pocket [chemical binding]; other site 717785008839 membrane-bound complex binding site; other site 717785008840 hinge residues; other site 717785008841 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 717785008842 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 717785008843 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 717785008844 Cytochrome c; Region: Cytochrom_C; pfam00034 717785008845 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785008846 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 717785008847 D-pathway; other site 717785008848 Putative ubiquinol binding site [chemical binding]; other site 717785008849 Low-spin heme (heme b) binding site [chemical binding]; other site 717785008850 Putative water exit pathway; other site 717785008851 Binuclear center (heme o3/CuB) [ion binding]; other site 717785008852 K-pathway; other site 717785008853 Putative proton exit pathway; other site 717785008854 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 717785008855 Subunit I/III interface [polypeptide binding]; other site 717785008856 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 717785008857 Cytochrome c; Region: Cytochrom_C; pfam00034 717785008858 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785008859 Sulfatase; Region: Sulfatase; pfam00884 717785008860 Domain of unknown function (DUF202); Region: DUF202; pfam02656 717785008861 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 717785008862 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 717785008863 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 717785008864 oxidoreductase; Provisional; Region: PRK10015 717785008865 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 717785008866 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 717785008867 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785008868 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 717785008869 Ligand binding site [chemical binding]; other site 717785008870 Electron transfer flavoprotein domain; Region: ETF; pfam01012 717785008871 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 717785008872 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 717785008873 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 717785008874 trimer interface [polypeptide binding]; other site 717785008875 active site 717785008876 substrate binding site [chemical binding]; other site 717785008877 CoA binding site [chemical binding]; other site 717785008878 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 717785008879 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 717785008880 active site 717785008881 catalytic residues [active] 717785008882 metal binding site [ion binding]; metal-binding site 717785008883 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785008884 metal binding site 2 [ion binding]; metal-binding site 717785008885 putative DNA binding helix; other site 717785008886 metal binding site 1 [ion binding]; metal-binding site 717785008887 dimer interface [polypeptide binding]; other site 717785008888 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 717785008889 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 717785008890 Nucleotide-binding sites [chemical binding]; other site 717785008891 Walker A motif; other site 717785008892 Switch I region of nucleotide binding site; other site 717785008893 Fe4S4 binding sites [ion binding]; other site 717785008894 Switch II region of nucleotide binding site; other site 717785008895 Response regulator receiver domain; Region: Response_reg; pfam00072 717785008896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785008897 active site 717785008898 phosphorylation site [posttranslational modification] 717785008899 intermolecular recognition site; other site 717785008900 dimerization interface [polypeptide binding]; other site 717785008901 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 717785008902 ArsC family; Region: ArsC; pfam03960 717785008903 putative catalytic residues [active] 717785008904 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 717785008905 NADPH bind site [chemical binding]; other site 717785008906 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 717785008907 putative FMN binding site [chemical binding]; other site 717785008908 NADPH bind site [chemical binding]; other site 717785008909 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 717785008910 active site residue [active] 717785008911 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785008912 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785008913 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 717785008914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 717785008915 binding surface 717785008916 TPR motif; other site 717785008917 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 717785008918 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 717785008919 putative GSH binding site [chemical binding]; other site 717785008920 catalytic residues [active] 717785008921 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 717785008922 dimer interface [polypeptide binding]; other site 717785008923 [2Fe-2S] cluster binding site [ion binding]; other site 717785008924 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 717785008925 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 717785008926 apolar tunnel; other site 717785008927 heme binding site [chemical binding]; other site 717785008928 dimerization interface [polypeptide binding]; other site 717785008929 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 717785008930 iron-sulfur cluster [ion binding]; other site 717785008931 [2Fe-2S] cluster binding site [ion binding]; other site 717785008932 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 717785008933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785008934 catalytic loop [active] 717785008935 iron binding site [ion binding]; other site 717785008936 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785008937 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785008938 inhibitor-cofactor binding pocket; inhibition site 717785008939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008940 catalytic residue [active] 717785008941 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 717785008942 NifZ domain; Region: NifZ; pfam04319 717785008943 NifZ domain; Region: NifZ; pfam04319 717785008944 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 717785008945 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 717785008946 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 717785008947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785008948 FeS/SAM binding site; other site 717785008949 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 717785008950 SIR2-like domain; Region: SIR2_2; pfam13289 717785008951 NifT/FixU protein; Region: NifT; pfam06988 717785008952 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 717785008953 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 717785008954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785008955 catalytic residue [active] 717785008956 NifU-like domain; Region: NifU; pfam01106 717785008957 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 717785008958 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 717785008959 iron-sulfur cluster [ion binding]; other site 717785008960 [2Fe-2S] cluster binding site [ion binding]; other site 717785008961 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 717785008962 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 717785008963 active site residue [active] 717785008964 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 717785008965 active site residue [active] 717785008966 NifQ; Region: NifQ; pfam04891 717785008967 Rop-like; Region: Rop-like; pfam05082 717785008968 probable nitrogen fixation protein; Region: TIGR02935 717785008969 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 717785008970 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 717785008971 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 717785008972 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 717785008973 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 717785008974 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 717785008975 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 717785008976 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 717785008977 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 717785008978 MoFe protein beta/alpha subunit interactions; other site 717785008979 Beta subunit P cluster binding residues; other site 717785008980 MoFe protein beta subunit/Fe protein contacts; other site 717785008981 MoFe protein dimer/ dimer interactions; other site 717785008982 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 717785008983 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 717785008984 MoFe protein alpha/beta subunit interactions; other site 717785008985 Alpha subunit P cluster binding residues; other site 717785008986 FeMoco binding residues [chemical binding]; other site 717785008987 MoFe protein alpha subunit/Fe protein contacts; other site 717785008988 MoFe protein dimer/ dimer interactions; other site 717785008989 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 717785008990 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 717785008991 Nucleotide-binding sites [chemical binding]; other site 717785008992 Walker A motif; other site 717785008993 Switch I region of nucleotide binding site; other site 717785008994 Fe4S4 binding sites [ion binding]; other site 717785008995 Switch II region of nucleotide binding site; other site 717785008996 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 717785008997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 717785008998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 717785008999 dimer interface [polypeptide binding]; other site 717785009000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009001 catalytic residue [active] 717785009002 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785009003 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785009004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785009005 catalytic residue [active] 717785009006 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 717785009007 FeS assembly protein SufD; Region: sufD; TIGR01981 717785009008 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 717785009009 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 717785009010 Walker A/P-loop; other site 717785009011 ATP binding site [chemical binding]; other site 717785009012 Q-loop/lid; other site 717785009013 ABC transporter signature motif; other site 717785009014 Walker B; other site 717785009015 D-loop; other site 717785009016 H-loop/switch region; other site 717785009017 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 717785009018 putative ABC transporter; Region: ycf24; CHL00085 717785009019 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 717785009020 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 717785009021 molybdenum transport protein ModD; Provisional; Region: PRK06096 717785009022 dimerization interface [polypeptide binding]; other site 717785009023 active site 717785009024 Nif-specific regulatory protein; Region: nifA; TIGR01817 717785009025 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 717785009026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785009027 Walker A motif; other site 717785009028 ATP binding site [chemical binding]; other site 717785009029 Walker B motif; other site 717785009030 arginine finger; other site 717785009031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785009032 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 717785009033 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 717785009034 iron-sulfur cluster [ion binding]; other site 717785009035 [2Fe-2S] cluster binding site [ion binding]; other site 717785009036 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785009037 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 717785009038 C-terminal domain interface [polypeptide binding]; other site 717785009039 GSH binding site (G-site) [chemical binding]; other site 717785009040 dimer interface [polypeptide binding]; other site 717785009041 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 717785009042 N-terminal domain interface [polypeptide binding]; other site 717785009043 dimer interface [polypeptide binding]; other site 717785009044 substrate binding pocket (H-site) [chemical binding]; other site 717785009045 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 717785009046 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 717785009047 Uncharacterized conserved protein [Function unknown]; Region: COG1262 717785009048 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 717785009049 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785009050 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785009051 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 717785009052 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 717785009053 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 717785009054 catalytic Zn binding site [ion binding]; other site 717785009055 structural Zn binding site [ion binding]; other site 717785009056 NAD(P) binding site [chemical binding]; other site 717785009057 Cytochrome c; Region: Cytochrom_C; cl11414 717785009058 Cytochrome c; Region: Cytochrom_C; cl11414 717785009059 Cupin domain; Region: Cupin_2; cl17218 717785009060 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 717785009061 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 717785009062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 717785009063 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 717785009064 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 717785009065 Walker A/P-loop; other site 717785009066 ATP binding site [chemical binding]; other site 717785009067 Q-loop/lid; other site 717785009068 ABC transporter signature motif; other site 717785009069 Walker B; other site 717785009070 D-loop; other site 717785009071 H-loop/switch region; other site 717785009072 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 717785009073 putative carbohydrate binding site [chemical binding]; other site 717785009074 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 717785009075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 717785009076 EthD domain; Region: EthD; cl17553 717785009077 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 717785009078 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785009079 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 717785009080 CAAX protease self-immunity; Region: Abi; cl00558 717785009081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785009082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785009083 Fusaric acid resistance protein family; Region: FUSC; pfam04632 717785009084 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 717785009085 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 717785009086 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785009087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785009088 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785009089 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 717785009090 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 717785009091 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785009092 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 717785009093 Walker A/P-loop; other site 717785009094 ATP binding site [chemical binding]; other site 717785009095 Q-loop/lid; other site 717785009096 ABC transporter signature motif; other site 717785009097 Walker B; other site 717785009098 D-loop; other site 717785009099 H-loop/switch region; other site 717785009100 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 717785009101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785009102 Walker A/P-loop; other site 717785009103 ATP binding site [chemical binding]; other site 717785009104 Q-loop/lid; other site 717785009105 ABC transporter signature motif; other site 717785009106 Walker B; other site 717785009107 D-loop; other site 717785009108 H-loop/switch region; other site 717785009109 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 717785009110 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 717785009111 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 717785009112 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 717785009113 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 717785009114 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 717785009115 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785009116 N-terminal plug; other site 717785009117 ligand-binding site [chemical binding]; other site 717785009118 Imelysin; Region: Peptidase_M75; pfam09375 717785009119 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 717785009120 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 717785009121 Imelysin; Region: Peptidase_M75; pfam09375 717785009122 Iron permease FTR1 family; Region: FTR1; cl00475 717785009123 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 717785009124 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 717785009125 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 717785009126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 717785009127 ABC-ATPase subunit interface; other site 717785009128 dimer interface [polypeptide binding]; other site 717785009129 putative PBP binding regions; other site 717785009130 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 717785009131 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 717785009132 metal binding site [ion binding]; metal-binding site 717785009133 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 717785009134 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 717785009135 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785009136 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785009137 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785009138 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785009139 Cytochrome c553 [Energy production and conversion]; Region: COG2863 717785009140 Cytochrome c; Region: Cytochrom_C; pfam00034 717785009141 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785009142 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 717785009143 Trp docking motif [polypeptide binding]; other site 717785009144 active site 717785009145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785009146 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 717785009147 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 717785009148 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 717785009149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785009150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785009151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 717785009152 putative effector binding pocket; other site 717785009153 putative dimerization interface [polypeptide binding]; other site 717785009154 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 717785009155 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 717785009156 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 717785009157 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 717785009158 TPP-binding site; other site 717785009159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785009160 PYR/PP interface [polypeptide binding]; other site 717785009161 dimer interface [polypeptide binding]; other site 717785009162 TPP binding site [chemical binding]; other site 717785009163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785009164 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 717785009165 VacJ like lipoprotein; Region: VacJ; cl01073 717785009166 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 717785009167 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785009168 ligand binding site; other site 717785009169 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 717785009170 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 717785009171 B12 binding site [chemical binding]; other site 717785009172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785009173 FeS/SAM binding site; other site 717785009174 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 717785009175 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 717785009176 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 717785009177 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 717785009178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785009179 FeS/SAM binding site; other site 717785009180 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 717785009181 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 717785009182 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 717785009183 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 717785009184 Active site cavity [active] 717785009185 catalytic acid [active] 717785009186 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 717785009187 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 717785009188 active site lid residues [active] 717785009189 substrate binding pocket [chemical binding]; other site 717785009190 catalytic residues [active] 717785009191 substrate-Mg2+ binding site; other site 717785009192 aspartate-rich region 1; other site 717785009193 aspartate-rich region 2; other site 717785009194 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 717785009195 active site lid residues [active] 717785009196 substrate binding pocket [chemical binding]; other site 717785009197 catalytic residues [active] 717785009198 substrate-Mg2+ binding site; other site 717785009199 aspartate-rich region 1; other site 717785009200 aspartate-rich region 2; other site 717785009201 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 717785009202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785009203 active site 717785009204 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785009205 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 717785009206 putative NADP binding site [chemical binding]; other site 717785009207 putative substrate binding site [chemical binding]; other site 717785009208 active site 717785009209 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 717785009210 NHL repeat; Region: NHL; pfam01436 717785009211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785009212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785009213 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785009214 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785009215 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785009216 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 717785009217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785009218 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 717785009219 NAD(P) binding site [chemical binding]; other site 717785009220 active site 717785009221 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717785009222 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785009223 Walker A/P-loop; other site 717785009224 ATP binding site [chemical binding]; other site 717785009225 Q-loop/lid; other site 717785009226 ABC transporter signature motif; other site 717785009227 Walker B; other site 717785009228 D-loop; other site 717785009229 H-loop/switch region; other site 717785009230 ABC-2 type transporter; Region: ABC2_membrane; cl17235 717785009231 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785009232 betaine aldehyde dehydrogenase; Region: PLN02467 717785009233 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 717785009234 NAD(P) binding site [chemical binding]; other site 717785009235 catalytic residues [active] 717785009236 catalytic residues [active] 717785009237 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 717785009238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785009239 inhibitor-cofactor binding pocket; inhibition site 717785009240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009241 catalytic residue [active] 717785009242 Dehydratase large subunit; Region: Dehydratase_LU; pfam02286 717785009243 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 717785009244 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 717785009245 alpha-beta subunit interface [polypeptide binding]; other site 717785009246 alpha-gamma subunit interface [polypeptide binding]; other site 717785009247 active site 717785009248 substrate and K+ binding site; other site 717785009249 K+ binding site [ion binding]; other site 717785009250 cobalamin binding site [chemical binding]; other site 717785009251 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 717785009252 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 717785009253 Isochorismatase family; Region: Isochorismatase; pfam00857 717785009254 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785009255 catalytic triad [active] 717785009256 conserved cis-peptide bond; other site 717785009257 Amino acid permease; Region: AA_permease_2; pfam13520 717785009258 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 717785009259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785009260 NAD(P) binding site [chemical binding]; other site 717785009261 active site 717785009262 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785009263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785009264 SurA N-terminal domain; Region: SurA_N; pfam09312 717785009265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785009266 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 717785009267 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 717785009268 active site 717785009269 substrate binding site [chemical binding]; other site 717785009270 ATP binding site [chemical binding]; other site 717785009271 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 717785009272 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 717785009273 tetrameric interface [polypeptide binding]; other site 717785009274 NAD binding site [chemical binding]; other site 717785009275 catalytic residues [active] 717785009276 substrate binding site [chemical binding]; other site 717785009277 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785009278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009279 dimer interface [polypeptide binding]; other site 717785009280 conserved gate region; other site 717785009281 putative PBP binding loops; other site 717785009282 ABC-ATPase subunit interface; other site 717785009283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009284 dimer interface [polypeptide binding]; other site 717785009285 putative PBP binding loops; other site 717785009286 ABC-ATPase subunit interface; other site 717785009287 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785009288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785009289 Walker A/P-loop; other site 717785009290 ATP binding site [chemical binding]; other site 717785009291 Q-loop/lid; other site 717785009292 ABC transporter signature motif; other site 717785009293 Walker B; other site 717785009294 D-loop; other site 717785009295 H-loop/switch region; other site 717785009296 TOBE domain; Region: TOBE_2; pfam08402 717785009297 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717785009298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785009299 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 717785009300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785009301 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 717785009302 Walker A/P-loop; other site 717785009303 ATP binding site [chemical binding]; other site 717785009304 Q-loop/lid; other site 717785009305 ABC transporter signature motif; other site 717785009306 Walker B; other site 717785009307 D-loop; other site 717785009308 H-loop/switch region; other site 717785009309 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 717785009310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009311 dimer interface [polypeptide binding]; other site 717785009312 conserved gate region; other site 717785009313 putative PBP binding loops; other site 717785009314 ABC-ATPase subunit interface; other site 717785009315 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 717785009316 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785009317 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 717785009318 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 717785009319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785009320 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 717785009321 DNA binding site [nucleotide binding] 717785009322 active site 717785009323 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785009324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785009325 DNA-binding site [nucleotide binding]; DNA binding site 717785009326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785009327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009328 homodimer interface [polypeptide binding]; other site 717785009329 catalytic residue [active] 717785009330 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785009331 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 717785009332 putative substrate binding pocket [chemical binding]; other site 717785009333 AC domain interface; other site 717785009334 catalytic triad [active] 717785009335 AB domain interface; other site 717785009336 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 717785009337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785009338 ATP binding site [chemical binding]; other site 717785009339 putative Mg++ binding site [ion binding]; other site 717785009340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785009341 nucleotide binding region [chemical binding]; other site 717785009342 ATP-binding site [chemical binding]; other site 717785009343 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 717785009344 HRDC domain; Region: HRDC; pfam00570 717785009345 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 717785009346 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 717785009347 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 717785009348 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 717785009349 dimer interface [polypeptide binding]; other site 717785009350 motif 1; other site 717785009351 motif 2; other site 717785009352 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785009353 active site 717785009354 motif 3; other site 717785009355 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 717785009356 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 717785009357 dimer interface [polypeptide binding]; other site 717785009358 motif 1; other site 717785009359 active site 717785009360 motif 2; other site 717785009361 motif 3; other site 717785009362 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 717785009363 anticodon binding site; other site 717785009364 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 717785009365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 717785009366 cobalamin synthase; Reviewed; Region: cobS; PRK00235 717785009367 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 717785009368 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 717785009369 putative dimer interface [polypeptide binding]; other site 717785009370 active site pocket [active] 717785009371 putative cataytic base [active] 717785009372 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 717785009373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 717785009374 Cysteine-rich domain; Region: CCG; pfam02754 717785009375 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 717785009376 FAD binding domain; Region: FAD_binding_4; pfam01565 717785009377 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 717785009378 FAD binding domain; Region: FAD_binding_4; pfam01565 717785009379 glutamate--cysteine ligase; Region: PLN02611 717785009380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 717785009381 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 717785009382 UbiA prenyltransferase family; Region: UbiA; pfam01040 717785009383 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 717785009384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785009385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785009386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785009387 Walker A/P-loop; other site 717785009388 ATP binding site [chemical binding]; other site 717785009389 Q-loop/lid; other site 717785009390 ABC transporter signature motif; other site 717785009391 Walker B; other site 717785009392 D-loop; other site 717785009393 H-loop/switch region; other site 717785009394 Putative phosphatase (DUF442); Region: DUF442; cl17385 717785009395 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 717785009396 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 717785009397 putative acyl-acceptor binding pocket; other site 717785009398 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 717785009399 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 717785009400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785009401 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 717785009402 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 717785009403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 717785009404 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 717785009405 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 717785009406 generic binding surface II; other site 717785009407 generic binding surface I; other site 717785009408 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 717785009409 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 717785009410 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 717785009411 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 717785009412 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785009413 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785009414 nucleophile elbow; other site 717785009415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 717785009416 nucleoside/Zn binding site; other site 717785009417 dimer interface [polypeptide binding]; other site 717785009418 catalytic motif [active] 717785009419 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 717785009420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785009421 RNA binding surface [nucleotide binding]; other site 717785009422 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 717785009423 active site 717785009424 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 717785009425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785009426 S-adenosylmethionine binding site [chemical binding]; other site 717785009427 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 717785009428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009429 glucose/galactose transporter; Region: gluP; TIGR01272 717785009430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009431 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 717785009432 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 717785009433 heme binding site [chemical binding]; other site 717785009434 ferroxidase pore; other site 717785009435 ferroxidase diiron center [ion binding]; other site 717785009436 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 717785009437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009438 ATP binding site [chemical binding]; other site 717785009439 Mg2+ binding site [ion binding]; other site 717785009440 G-X-G motif; other site 717785009441 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 717785009442 ATP binding site [chemical binding]; other site 717785009443 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 717785009444 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 717785009445 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 717785009446 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 717785009447 dimer interface [polypeptide binding]; other site 717785009448 active site 717785009449 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785009450 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785009451 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785009452 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785009453 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785009454 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785009455 lipoprotein signal peptidase; Provisional; Region: PRK14796 717785009456 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 717785009457 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785009458 active site 717785009459 HIGH motif; other site 717785009460 nucleotide binding site [chemical binding]; other site 717785009461 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 717785009462 active site 717785009463 KMSKS motif; other site 717785009464 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 717785009465 tRNA binding surface [nucleotide binding]; other site 717785009466 anticodon binding site; other site 717785009467 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 717785009468 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 717785009469 active site 717785009470 Riboflavin kinase; Region: Flavokinase; pfam01687 717785009471 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 717785009472 dimer interaction site [polypeptide binding]; other site 717785009473 substrate-binding tunnel; other site 717785009474 active site 717785009475 catalytic site [active] 717785009476 substrate binding site [chemical binding]; other site 717785009477 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 717785009478 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 717785009479 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 717785009480 Sulfate transporter family; Region: Sulfate_transp; pfam00916 717785009481 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 717785009482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785009483 non-specific DNA binding site [nucleotide binding]; other site 717785009484 salt bridge; other site 717785009485 sequence-specific DNA binding site [nucleotide binding]; other site 717785009486 acyl-CoA synthetase; Validated; Region: PRK08162 717785009487 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 717785009488 acyl-activating enzyme (AAE) consensus motif; other site 717785009489 putative active site [active] 717785009490 AMP binding site [chemical binding]; other site 717785009491 putative CoA binding site [chemical binding]; other site 717785009492 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 717785009493 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785009494 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 717785009495 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 717785009496 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785009497 putative C-terminal domain interface [polypeptide binding]; other site 717785009498 putative GSH binding site (G-site) [chemical binding]; other site 717785009499 putative dimer interface [polypeptide binding]; other site 717785009500 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 717785009501 putative N-terminal domain interface [polypeptide binding]; other site 717785009502 putative dimer interface [polypeptide binding]; other site 717785009503 putative substrate binding pocket (H-site) [chemical binding]; other site 717785009504 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 717785009505 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 717785009506 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 717785009507 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785009508 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 717785009509 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 717785009510 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 717785009511 putative heme binding pocket [chemical binding]; other site 717785009512 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 717785009513 putative hydrophobic ligand binding site [chemical binding]; other site 717785009514 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 717785009515 putative hydrophobic ligand binding site [chemical binding]; other site 717785009516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785009517 dimerization interface [polypeptide binding]; other site 717785009518 putative DNA binding site [nucleotide binding]; other site 717785009519 putative Zn2+ binding site [ion binding]; other site 717785009520 Uncharacterized small protein [Function unknown]; Region: COG5570 717785009521 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 717785009522 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 717785009523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 717785009524 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 717785009525 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 717785009526 active site 717785009527 DNA binding site [nucleotide binding] 717785009528 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 717785009529 DNA binding site [nucleotide binding] 717785009530 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 717785009531 homodimer interface [polypeptide binding]; other site 717785009532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009533 catalytic residue [active] 717785009534 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 717785009535 Amidase; Region: Amidase; cl11426 717785009536 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 717785009537 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 717785009538 dimerization interface [polypeptide binding]; other site 717785009539 ligand binding site [chemical binding]; other site 717785009540 NADP binding site [chemical binding]; other site 717785009541 catalytic site [active] 717785009542 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 717785009543 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785009544 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 717785009545 TolR protein; Region: tolR; TIGR02801 717785009546 TonB C terminal; Region: TonB_2; pfam13103 717785009547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785009548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785009549 dimer interface [polypeptide binding]; other site 717785009550 phosphorylation site [posttranslational modification] 717785009551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009552 ATP binding site [chemical binding]; other site 717785009553 Mg2+ binding site [ion binding]; other site 717785009554 G-X-G motif; other site 717785009555 Domain of unknown function DUF87; Region: DUF87; pfam01935 717785009556 AAA-like domain; Region: AAA_10; pfam12846 717785009557 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 717785009558 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 717785009559 Substrate binding site; other site 717785009560 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 717785009561 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 717785009562 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 717785009563 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 717785009564 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 717785009565 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785009566 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717785009567 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785009568 protein binding site [polypeptide binding]; other site 717785009569 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785009570 protein binding site [polypeptide binding]; other site 717785009571 HflC protein; Region: hflC; TIGR01932 717785009572 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 717785009573 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 717785009574 HflK protein; Region: hflK; TIGR01933 717785009575 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 717785009576 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 717785009577 folate binding site [chemical binding]; other site 717785009578 NADP+ binding site [chemical binding]; other site 717785009579 thymidylate synthase; Reviewed; Region: thyA; PRK01827 717785009580 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 717785009581 dimerization interface [polypeptide binding]; other site 717785009582 active site 717785009583 CAAX protease self-immunity; Region: Abi; pfam02517 717785009584 Stringent starvation protein B; Region: SspB; pfam04386 717785009585 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 717785009586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785009587 dimerization interface [polypeptide binding]; other site 717785009588 putative DNA binding site [nucleotide binding]; other site 717785009589 putative Zn2+ binding site [ion binding]; other site 717785009590 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 717785009591 putative hydrophobic ligand binding site [chemical binding]; other site 717785009592 Uncharacterized conserved protein [Function unknown]; Region: COG3791 717785009593 fumarate hydratase; Reviewed; Region: fumC; PRK00485 717785009594 Class II fumarases; Region: Fumarase_classII; cd01362 717785009595 active site 717785009596 tetramer interface [polypeptide binding]; other site 717785009597 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 717785009598 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 717785009599 Peptidase M15; Region: Peptidase_M15_3; cl01194 717785009600 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 717785009601 DNA-binding site [nucleotide binding]; DNA binding site 717785009602 RNA-binding motif; other site 717785009603 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 717785009604 rRNA binding site [nucleotide binding]; other site 717785009605 predicted 30S ribosome binding site; other site 717785009606 TLC ATP/ADP transporter; Region: TLC; cl03940 717785009607 TLC ATP/ADP transporter; Region: TLC; cl03940 717785009608 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 717785009609 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 717785009610 MgtC family; Region: MgtC; pfam02308 717785009611 DNA polymerase I; Provisional; Region: PRK05755 717785009612 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 717785009613 active site 717785009614 metal binding site 1 [ion binding]; metal-binding site 717785009615 putative 5' ssDNA interaction site; other site 717785009616 metal binding site 3; metal-binding site 717785009617 metal binding site 2 [ion binding]; metal-binding site 717785009618 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 717785009619 putative DNA binding site [nucleotide binding]; other site 717785009620 putative metal binding site [ion binding]; other site 717785009621 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 717785009622 active site 717785009623 catalytic site [active] 717785009624 substrate binding site [chemical binding]; other site 717785009625 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 717785009626 active site 717785009627 DNA binding site [nucleotide binding] 717785009628 catalytic site [active] 717785009629 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 717785009630 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 717785009631 catalytic triad [active] 717785009632 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785009633 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 717785009634 putative active site [active] 717785009635 catalytic triad [active] 717785009636 putative dimer interface [polypeptide binding]; other site 717785009637 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785009638 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785009639 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785009640 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 717785009641 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 717785009642 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 717785009643 putative active site [active] 717785009644 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 717785009645 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 717785009646 classical (c) SDRs; Region: SDR_c; cd05233 717785009647 NAD(P) binding site [chemical binding]; other site 717785009648 active site 717785009649 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 717785009650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785009651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785009652 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785009653 putative effector binding pocket; other site 717785009654 putative dimerization interface [polypeptide binding]; other site 717785009655 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 717785009656 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 717785009657 Walker A/P-loop; other site 717785009658 ATP binding site [chemical binding]; other site 717785009659 Q-loop/lid; other site 717785009660 ABC transporter signature motif; other site 717785009661 Walker B; other site 717785009662 D-loop; other site 717785009663 H-loop/switch region; other site 717785009664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717785009665 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 717785009666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 717785009667 Phosphotransferase enzyme family; Region: APH; pfam01636 717785009668 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 717785009669 active site 717785009670 substrate binding site [chemical binding]; other site 717785009671 ATP binding site [chemical binding]; other site 717785009672 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 717785009673 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 717785009674 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 717785009675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717785009676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009677 dimer interface [polypeptide binding]; other site 717785009678 conserved gate region; other site 717785009679 putative PBP binding loops; other site 717785009680 ABC-ATPase subunit interface; other site 717785009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009682 dimer interface [polypeptide binding]; other site 717785009683 conserved gate region; other site 717785009684 putative PBP binding loops; other site 717785009685 ABC-ATPase subunit interface; other site 717785009686 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785009687 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785009688 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785009689 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785009690 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785009691 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785009692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785009693 motif II; other site 717785009694 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 717785009695 UreD urease accessory protein; Region: UreD; cl00530 717785009696 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 717785009697 urease subunit alpha; Reviewed; Region: ureC; PRK13308 717785009698 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 717785009699 subunit interactions [polypeptide binding]; other site 717785009700 active site 717785009701 flap region; other site 717785009702 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 717785009703 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 717785009704 alpha-gamma subunit interface [polypeptide binding]; other site 717785009705 beta-gamma subunit interface [polypeptide binding]; other site 717785009706 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 717785009707 alpha-beta subunit interface [polypeptide binding]; other site 717785009708 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 717785009709 UreF; Region: UreF; pfam01730 717785009710 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 717785009711 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 717785009712 dimer interface [polypeptide binding]; other site 717785009713 catalytic residues [active] 717785009714 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785009715 Sel1-like repeats; Region: SEL1; smart00671 717785009716 Sel1-like repeats; Region: SEL1; smart00671 717785009717 Sel1-like repeats; Region: SEL1; smart00671 717785009718 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 717785009719 iron-sulfur cluster [ion binding]; other site 717785009720 [2Fe-2S] cluster binding site [ion binding]; other site 717785009721 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 717785009722 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 717785009723 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 717785009724 Walker A/P-loop; other site 717785009725 ATP binding site [chemical binding]; other site 717785009726 Q-loop/lid; other site 717785009727 ABC transporter signature motif; other site 717785009728 Walker B; other site 717785009729 D-loop; other site 717785009730 H-loop/switch region; other site 717785009731 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 717785009732 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 717785009733 Walker A/P-loop; other site 717785009734 ATP binding site [chemical binding]; other site 717785009735 Q-loop/lid; other site 717785009736 ABC transporter signature motif; other site 717785009737 Walker B; other site 717785009738 D-loop; other site 717785009739 H-loop/switch region; other site 717785009740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717785009741 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785009742 TM-ABC transporter signature motif; other site 717785009743 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 717785009744 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785009745 TM-ABC transporter signature motif; other site 717785009746 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785009747 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 717785009748 ligand binding site [chemical binding]; other site 717785009749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785009750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785009751 active site 717785009752 phosphorylation site [posttranslational modification] 717785009753 intermolecular recognition site; other site 717785009754 dimerization interface [polypeptide binding]; other site 717785009755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785009756 DNA binding residues [nucleotide binding] 717785009757 dimerization interface [polypeptide binding]; other site 717785009758 PAS fold; Region: PAS_7; pfam12860 717785009759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785009760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785009761 dimer interface [polypeptide binding]; other site 717785009762 phosphorylation site [posttranslational modification] 717785009763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009764 ATP binding site [chemical binding]; other site 717785009765 Mg2+ binding site [ion binding]; other site 717785009766 G-X-G motif; other site 717785009767 Response regulator receiver domain; Region: Response_reg; pfam00072 717785009768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785009769 active site 717785009770 phosphorylation site [posttranslational modification] 717785009771 intermolecular recognition site; other site 717785009772 dimerization interface [polypeptide binding]; other site 717785009773 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785009774 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785009775 ligand binding site [chemical binding]; other site 717785009776 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 717785009777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 717785009778 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785009779 homotrimer interaction site [polypeptide binding]; other site 717785009780 putative active site [active] 717785009781 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 717785009782 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 717785009783 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 717785009784 NAD(P) binding site [chemical binding]; other site 717785009785 catalytic residues [active] 717785009786 acetylornithine deacetylase; Provisional; Region: PRK07522 717785009787 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 717785009788 metal binding site [ion binding]; metal-binding site 717785009789 putative dimer interface [polypeptide binding]; other site 717785009790 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 717785009791 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785009792 FMN binding site [chemical binding]; other site 717785009793 active site 717785009794 homodimer interface [polypeptide binding]; other site 717785009795 putative catalytic residue [active] 717785009796 4Fe-4S cluster binding site [ion binding]; other site 717785009797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785009798 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 717785009799 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785009800 FMN binding site [chemical binding]; other site 717785009801 active site 717785009802 homodimer interface [polypeptide binding]; other site 717785009803 putative catalytic residue [active] 717785009804 4Fe-4S cluster binding site [ion binding]; other site 717785009805 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785009806 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785009807 Walker A/P-loop; other site 717785009808 ATP binding site [chemical binding]; other site 717785009809 Q-loop/lid; other site 717785009810 ABC transporter signature motif; other site 717785009811 Walker B; other site 717785009812 D-loop; other site 717785009813 H-loop/switch region; other site 717785009814 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785009815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009816 dimer interface [polypeptide binding]; other site 717785009817 conserved gate region; other site 717785009818 putative PBP binding loops; other site 717785009819 ABC-ATPase subunit interface; other site 717785009820 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009821 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 717785009822 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 717785009823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785009824 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 717785009825 putative substrate binding pocket [chemical binding]; other site 717785009826 dimerization interface [polypeptide binding]; other site 717785009827 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 717785009828 active site 717785009829 SAM binding site [chemical binding]; other site 717785009830 homodimer interface [polypeptide binding]; other site 717785009831 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785009832 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785009833 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 717785009834 [4Fe-4S] binding site [ion binding]; other site 717785009835 molybdopterin cofactor binding site; other site 717785009836 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 717785009837 molybdopterin cofactor binding site; other site 717785009838 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 717785009839 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 717785009840 [2Fe-2S] cluster binding site [ion binding]; other site 717785009841 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 717785009842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785009843 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 717785009844 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785009845 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 717785009846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009847 putative substrate translocation pore; other site 717785009848 NMT1-like family; Region: NMT1_2; pfam13379 717785009849 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009850 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 717785009851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785009852 active site 717785009853 phosphorylation site [posttranslational modification] 717785009854 intermolecular recognition site; other site 717785009855 dimerization interface [polypeptide binding]; other site 717785009856 ANTAR domain; Region: ANTAR; pfam03861 717785009857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785009858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785009859 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785009860 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 717785009861 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 717785009862 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 717785009863 Nif-specific regulatory protein; Region: nifA; TIGR01817 717785009864 GAF domain; Region: GAF; pfam01590 717785009865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785009866 Walker A motif; other site 717785009867 ATP binding site [chemical binding]; other site 717785009868 Walker B motif; other site 717785009869 arginine finger; other site 717785009870 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785009871 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009872 NMT1-like family; Region: NMT1_2; pfam13379 717785009873 OsmC-like protein; Region: OsmC; pfam02566 717785009874 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785009875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785009876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785009877 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 717785009878 Rubredoxin; Region: Rubredoxin; pfam00301 717785009879 iron binding site [ion binding]; other site 717785009880 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 717785009881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785009882 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009884 dimer interface [polypeptide binding]; other site 717785009885 conserved gate region; other site 717785009886 putative PBP binding loops; other site 717785009887 ABC-ATPase subunit interface; other site 717785009888 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785009889 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 717785009890 Walker A/P-loop; other site 717785009891 ATP binding site [chemical binding]; other site 717785009892 Q-loop/lid; other site 717785009893 ABC transporter signature motif; other site 717785009894 Walker B; other site 717785009895 D-loop; other site 717785009896 H-loop/switch region; other site 717785009897 cyanate hydratase; Validated; Region: PRK02866 717785009898 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 717785009899 oligomer interface [polypeptide binding]; other site 717785009900 active site 717785009901 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 717785009902 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 717785009903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785009904 N-terminal plug; other site 717785009905 ligand-binding site [chemical binding]; other site 717785009906 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 717785009907 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 717785009908 putative active site [active] 717785009909 putative PHP Thumb interface [polypeptide binding]; other site 717785009910 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 717785009911 generic binding surface II; other site 717785009912 generic binding surface I; other site 717785009913 DNA Polymerase Y-family; Region: PolY_like; cd03468 717785009914 active site 717785009915 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 717785009916 DNA binding site [nucleotide binding] 717785009917 Uncharacterized conserved protein [Function unknown]; Region: COG4544 717785009918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785009919 dimerization interface [polypeptide binding]; other site 717785009920 PAS fold; Region: PAS_7; pfam12860 717785009921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785009922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009923 metal binding site [ion binding]; metal-binding site 717785009924 active site 717785009925 I-site; other site 717785009926 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009927 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 717785009928 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785009929 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 717785009930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009931 dimer interface [polypeptide binding]; other site 717785009932 conserved gate region; other site 717785009933 putative PBP binding loops; other site 717785009934 ABC-ATPase subunit interface; other site 717785009935 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785009936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785009937 dimer interface [polypeptide binding]; other site 717785009938 conserved gate region; other site 717785009939 putative PBP binding loops; other site 717785009940 ABC-ATPase subunit interface; other site 717785009941 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785009942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 717785009943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785009944 sequence-specific DNA binding site [nucleotide binding]; other site 717785009945 salt bridge; other site 717785009946 Cupin domain; Region: Cupin_2; pfam07883 717785009947 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785009948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785009949 Walker A/P-loop; other site 717785009950 ATP binding site [chemical binding]; other site 717785009951 Q-loop/lid; other site 717785009952 ABC transporter signature motif; other site 717785009953 Walker B; other site 717785009954 D-loop; other site 717785009955 H-loop/switch region; other site 717785009956 TOBE domain; Region: TOBE_2; pfam08402 717785009957 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 717785009958 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 717785009959 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 717785009960 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785009961 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 717785009962 Predicted dehydrogenase [General function prediction only]; Region: COG0579 717785009963 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785009964 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 717785009965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 717785009966 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785009967 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 717785009968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 717785009969 nucleotide binding site [chemical binding]; other site 717785009970 ethanolamine permease; Region: 2A0305; TIGR00908 717785009971 response regulator FixJ; Provisional; Region: fixJ; PRK09390 717785009972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785009973 active site 717785009974 phosphorylation site [posttranslational modification] 717785009975 intermolecular recognition site; other site 717785009976 dimerization interface [polypeptide binding]; other site 717785009977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785009978 DNA binding residues [nucleotide binding] 717785009979 dimerization interface [polypeptide binding]; other site 717785009980 MASE1; Region: MASE1; cl17823 717785009981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785009982 phosphorylation site [posttranslational modification] 717785009983 dimer interface [polypeptide binding]; other site 717785009984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009985 ATP binding site [chemical binding]; other site 717785009986 Mg2+ binding site [ion binding]; other site 717785009987 G-X-G motif; other site 717785009988 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 717785009989 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785009990 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 717785009991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785009992 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 717785009993 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 717785009994 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 717785009995 Moco binding site; other site 717785009996 metal coordination site [ion binding]; other site 717785009997 mercuric reductase; Validated; Region: PRK06370 717785009998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785009999 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785010000 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 717785010001 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 717785010002 substrate binding site [chemical binding]; other site 717785010003 ATP binding site [chemical binding]; other site 717785010004 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 717785010005 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 717785010006 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 717785010007 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785010008 HSP70 interaction site [polypeptide binding]; other site 717785010009 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 717785010010 substrate binding site [polypeptide binding]; other site 717785010011 dimer interface [polypeptide binding]; other site 717785010012 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 717785010013 nudix motif; other site 717785010014 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 717785010015 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 717785010016 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 717785010017 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785010018 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 717785010019 Soluble P-type ATPase [General function prediction only]; Region: COG4087 717785010020 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785010021 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785010022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010023 active site 717785010024 phosphorylation site [posttranslational modification] 717785010025 intermolecular recognition site; other site 717785010026 dimerization interface [polypeptide binding]; other site 717785010027 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785010028 DNA binding site [nucleotide binding] 717785010029 PAS domain S-box; Region: sensory_box; TIGR00229 717785010030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785010031 putative active site [active] 717785010032 heme pocket [chemical binding]; other site 717785010033 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785010034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785010035 putative active site [active] 717785010036 heme pocket [chemical binding]; other site 717785010037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785010038 dimer interface [polypeptide binding]; other site 717785010039 phosphorylation site [posttranslational modification] 717785010040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010041 ATP binding site [chemical binding]; other site 717785010042 Mg2+ binding site [ion binding]; other site 717785010043 G-X-G motif; other site 717785010044 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785010045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010046 active site 717785010047 phosphorylation site [posttranslational modification] 717785010048 intermolecular recognition site; other site 717785010049 dimerization interface [polypeptide binding]; other site 717785010050 Protein required for attachment to host cells; Region: Host_attach; pfam10116 717785010051 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 717785010052 CoA binding domain; Region: CoA_binding_2; pfam13380 717785010053 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 717785010054 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 717785010055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 717785010056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 717785010057 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 717785010058 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 717785010059 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 717785010060 FOG: CBS domain [General function prediction only]; Region: COG0517 717785010061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 717785010062 BON domain; Region: BON; pfam04972 717785010063 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 717785010064 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 717785010065 putative NAD(P) binding site [chemical binding]; other site 717785010066 putative substrate binding site [chemical binding]; other site 717785010067 catalytic Zn binding site [ion binding]; other site 717785010068 structural Zn binding site [ion binding]; other site 717785010069 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 717785010070 dimer interaction site [polypeptide binding]; other site 717785010071 substrate-binding tunnel; other site 717785010072 active site 717785010073 catalytic site [active] 717785010074 substrate binding site [chemical binding]; other site 717785010075 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 717785010076 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785010077 NAD binding site [chemical binding]; other site 717785010078 homotetramer interface [polypeptide binding]; other site 717785010079 homodimer interface [polypeptide binding]; other site 717785010080 substrate binding site [chemical binding]; other site 717785010081 active site 717785010082 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785010083 E3 interaction surface; other site 717785010084 lipoyl attachment site [posttranslational modification]; other site 717785010085 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 717785010086 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 717785010087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785010088 ligand binding site [chemical binding]; other site 717785010089 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785010090 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 717785010091 Catalytic site; other site 717785010092 AsmA family; Region: AsmA; pfam05170 717785010093 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 717785010094 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 717785010095 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785010096 Methyltransferase domain; Region: Methyltransf_12; pfam08242 717785010097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010098 putative transporter; Provisional; Region: PRK10504 717785010099 putative substrate translocation pore; other site 717785010100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010101 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 717785010102 Coenzyme A transferase; Region: CoA_trans; smart00882 717785010103 Coenzyme A transferase; Region: CoA_trans; cl17247 717785010104 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 717785010105 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 717785010106 protein binding site [polypeptide binding]; other site 717785010107 Domain of unknown function DUF59; Region: DUF59; pfam01883 717785010108 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 717785010109 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 717785010110 Walker A motif; other site 717785010111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 717785010112 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 717785010113 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 717785010114 GTP binding site; other site 717785010115 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 717785010116 Walker A motif; other site 717785010117 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 717785010118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785010119 FeS/SAM binding site; other site 717785010120 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 717785010121 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 717785010122 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 717785010123 Walker A/P-loop; other site 717785010124 ATP binding site [chemical binding]; other site 717785010125 Q-loop/lid; other site 717785010126 ABC transporter signature motif; other site 717785010127 Walker B; other site 717785010128 D-loop; other site 717785010129 H-loop/switch region; other site 717785010130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010131 active site 717785010132 phosphorylation site [posttranslational modification] 717785010133 intermolecular recognition site; other site 717785010134 dimerization interface [polypeptide binding]; other site 717785010135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 717785010136 active site 717785010137 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 717785010138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785010139 Walker A/P-loop; other site 717785010140 ATP binding site [chemical binding]; other site 717785010141 Q-loop/lid; other site 717785010142 ABC transporter signature motif; other site 717785010143 Walker B; other site 717785010144 D-loop; other site 717785010145 H-loop/switch region; other site 717785010146 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 717785010147 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 717785010148 Uncharacterized conserved protein [Function unknown]; Region: COG1434 717785010149 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717785010150 putative active site [active] 717785010151 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 717785010152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785010153 putative acyl-acceptor binding pocket; other site 717785010154 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 717785010155 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 717785010156 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 717785010157 active site 717785010158 dimer interface [polypeptide binding]; other site 717785010159 effector binding site; other site 717785010160 TSCPD domain; Region: TSCPD; pfam12637 717785010161 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 717785010162 prephenate dehydrogenase; Validated; Region: PRK08507 717785010163 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 717785010164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785010165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010166 homodimer interface [polypeptide binding]; other site 717785010167 catalytic residue [active] 717785010168 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 717785010169 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 717785010170 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785010171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785010172 S-adenosylmethionine binding site [chemical binding]; other site 717785010173 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785010174 Methyltransferase domain; Region: Methyltransf_11; pfam08241 717785010175 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 717785010176 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 717785010177 LabA_like proteins; Region: LabA_like; cd06167 717785010178 putative metal binding site [ion binding]; other site 717785010179 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 717785010180 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 717785010181 NAD(P) binding site [chemical binding]; other site 717785010182 homotetramer interface [polypeptide binding]; other site 717785010183 homodimer interface [polypeptide binding]; other site 717785010184 active site 717785010185 putative acyltransferase; Provisional; Region: PRK05790 717785010186 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785010187 dimer interface [polypeptide binding]; other site 717785010188 active site 717785010189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 717785010190 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 717785010191 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 717785010192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785010193 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010194 metal binding site [ion binding]; metal-binding site 717785010195 active site 717785010196 I-site; other site 717785010197 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785010198 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 717785010199 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 717785010200 Transglycosylase; Region: Transgly; cl17702 717785010201 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 717785010202 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 717785010203 substrate binding pocket [chemical binding]; other site 717785010204 chain length determination region; other site 717785010205 substrate-Mg2+ binding site; other site 717785010206 catalytic residues [active] 717785010207 aspartate-rich region 1; other site 717785010208 active site lid residues [active] 717785010209 aspartate-rich region 2; other site 717785010210 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 717785010211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 717785010212 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 717785010213 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 717785010214 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 717785010215 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 717785010216 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 717785010217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 717785010218 putative PBP binding regions; other site 717785010219 ABC-ATPase subunit interface; other site 717785010220 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 717785010221 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 717785010222 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785010223 metal binding site 2 [ion binding]; metal-binding site 717785010224 putative DNA binding helix; other site 717785010225 metal binding site 1 [ion binding]; metal-binding site 717785010226 dimer interface [polypeptide binding]; other site 717785010227 structural Zn2+ binding site [ion binding]; other site 717785010228 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 717785010229 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 717785010230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 717785010231 PRC-barrel domain; Region: PRC; pfam05239 717785010232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785010233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010234 putative substrate translocation pore; other site 717785010235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785010236 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 717785010237 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 717785010238 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 717785010239 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785010240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785010241 DNA-binding site [nucleotide binding]; DNA binding site 717785010242 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785010243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785010244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010245 homodimer interface [polypeptide binding]; other site 717785010246 catalytic residue [active] 717785010247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 717785010248 Methyltransferase domain; Region: Methyltransf_31; pfam13847 717785010249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785010250 S-adenosylmethionine binding site [chemical binding]; other site 717785010251 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785010252 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785010253 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 717785010254 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 717785010255 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 717785010256 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 717785010257 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 717785010258 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 717785010259 dimer interface [polypeptide binding]; other site 717785010260 anticodon binding site; other site 717785010261 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 717785010262 homodimer interface [polypeptide binding]; other site 717785010263 motif 1; other site 717785010264 active site 717785010265 motif 2; other site 717785010266 GAD domain; Region: GAD; pfam02938 717785010267 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785010268 active site 717785010269 motif 3; other site 717785010270 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 717785010271 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 717785010272 catalytic site [active] 717785010273 putative active site [active] 717785010274 putative substrate binding site [chemical binding]; other site 717785010275 HRDC domain; Region: HRDC; pfam00570 717785010276 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 717785010277 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785010278 HSP70 interaction site [polypeptide binding]; other site 717785010279 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 717785010280 substrate binding site [polypeptide binding]; other site 717785010281 dimer interface [polypeptide binding]; other site 717785010282 exopolyphosphatase; Region: exo_poly_only; TIGR03706 717785010283 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 717785010284 polyphosphate kinase; Provisional; Region: PRK05443 717785010285 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 717785010286 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 717785010287 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 717785010288 putative domain interface [polypeptide binding]; other site 717785010289 putative active site [active] 717785010290 catalytic site [active] 717785010291 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 717785010292 putative active site [active] 717785010293 putative domain interface [polypeptide binding]; other site 717785010294 catalytic site [active] 717785010295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 717785010296 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 717785010297 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785010298 Domain of unknown function DUF20; Region: UPF0118; pfam01594 717785010299 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 717785010300 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 717785010301 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 717785010302 dimerization interface [polypeptide binding]; other site 717785010303 putative ATP binding site [chemical binding]; other site 717785010304 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785010305 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 717785010306 Trp docking motif [polypeptide binding]; other site 717785010307 dimer interface [polypeptide binding]; other site 717785010308 active site 717785010309 small subunit binding site [polypeptide binding]; other site 717785010310 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 717785010311 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 717785010312 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 717785010313 active site 717785010314 TDP-binding site; other site 717785010315 acceptor substrate-binding pocket; other site 717785010316 homodimer interface [polypeptide binding]; other site 717785010317 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 717785010318 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 717785010319 active site 717785010320 substrate binding site [chemical binding]; other site 717785010321 cosubstrate binding site; other site 717785010322 catalytic site [active] 717785010323 Cytochrome P450; Region: p450; cl12078 717785010324 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 717785010325 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 717785010326 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 717785010327 Evidence 4 : Homologs of previously reported genes of unknown function 717785010328 Evidence 4 : Homologs of previously reported genes of unknown function 717785010329 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 717785010330 active site 717785010331 multimer interface [polypeptide binding]; other site 717785010332 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 717785010333 hypothetical protein; Provisional; Region: PRK09272 717785010334 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 717785010335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785010336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785010337 ABC transporter; Region: ABC_tran_2; pfam12848 717785010338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 717785010339 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 717785010340 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 717785010341 dimer interface [polypeptide binding]; other site 717785010342 motif 1; other site 717785010343 active site 717785010344 motif 2; other site 717785010345 motif 3; other site 717785010346 type II secretion system protein J; Region: gspJ; TIGR01711 717785010347 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 717785010348 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 717785010349 tandem repeat interface [polypeptide binding]; other site 717785010350 oligomer interface [polypeptide binding]; other site 717785010351 active site residues [active] 717785010352 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 717785010353 Methyltransferase domain; Region: Methyltransf_26; pfam13659 717785010354 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 717785010355 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 717785010356 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 717785010357 substrate binding pocket [chemical binding]; other site 717785010358 chain length determination region; other site 717785010359 substrate-Mg2+ binding site; other site 717785010360 catalytic residues [active] 717785010361 aspartate-rich region 1; other site 717785010362 active site lid residues [active] 717785010363 aspartate-rich region 2; other site 717785010364 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 717785010365 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 717785010366 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 717785010367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785010368 binding surface 717785010369 TPR motif; other site 717785010370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785010371 binding surface 717785010372 TPR motif; other site 717785010373 TPR repeat; Region: TPR_11; pfam13414 717785010374 TPR repeat; Region: TPR_11; pfam13414 717785010375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785010376 binding surface 717785010377 TPR motif; other site 717785010378 Tetratricopeptide repeat; Region: TPR_9; pfam13371 717785010379 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785010380 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 717785010381 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 717785010382 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 717785010383 Fe-S cluster binding site [ion binding]; other site 717785010384 active site 717785010385 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 717785010386 MPT binding site; other site 717785010387 trimer interface [polypeptide binding]; other site 717785010388 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 717785010389 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 717785010390 Probable Catalytic site; other site 717785010391 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 717785010392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785010393 FeS/SAM binding site; other site 717785010394 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 717785010395 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785010396 active site 717785010397 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785010398 DNA methylase; Region: N6_N4_Mtase; pfam01555 717785010399 PAS fold; Region: PAS_7; pfam12860 717785010400 PAS domain S-box; Region: sensory_box; TIGR00229 717785010401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785010402 putative active site [active] 717785010403 heme pocket [chemical binding]; other site 717785010404 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785010405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010406 metal binding site [ion binding]; metal-binding site 717785010407 active site 717785010408 I-site; other site 717785010409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785010410 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 717785010411 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785010412 minor groove reading motif; other site 717785010413 helix-hairpin-helix signature motif; other site 717785010414 substrate binding pocket [chemical binding]; other site 717785010415 active site 717785010416 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 717785010417 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 717785010418 DNA binding and oxoG recognition site [nucleotide binding] 717785010419 Protein of unknown function (DUF721); Region: DUF721; cl02324 717785010420 Thioredoxin; Region: Thioredoxin_4; pfam13462 717785010421 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 717785010422 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 717785010423 Thioredoxin; Region: Thioredoxin_4; pfam13462 717785010424 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717785010425 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 717785010426 Walker A/P-loop; other site 717785010427 ATP binding site [chemical binding]; other site 717785010428 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 717785010429 Q-loop/lid; other site 717785010430 ABC transporter signature motif; other site 717785010431 Walker B; other site 717785010432 D-loop; other site 717785010433 H-loop/switch region; other site 717785010434 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 717785010435 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 717785010436 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 717785010437 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 717785010438 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 717785010439 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 717785010440 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 717785010441 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 717785010442 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 717785010443 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 717785010444 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 717785010445 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 717785010446 putative active site [active] 717785010447 putative substrate binding site [chemical binding]; other site 717785010448 ATP binding site [chemical binding]; other site 717785010449 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 717785010450 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785010451 active site 717785010452 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 717785010453 catalytic triad [active] 717785010454 dimer interface [polypeptide binding]; other site 717785010455 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 717785010456 hypothetical protein; Validated; Region: PRK00228 717785010457 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 717785010458 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 717785010459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785010460 PAS fold; Region: PAS_3; pfam08447 717785010461 putative active site [active] 717785010462 heme pocket [chemical binding]; other site 717785010463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785010464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010465 metal binding site [ion binding]; metal-binding site 717785010466 active site 717785010467 I-site; other site 717785010468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785010469 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 717785010470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 717785010471 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785010472 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785010473 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785010474 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 717785010475 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 717785010476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010477 catalytic residue [active] 717785010478 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 717785010479 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785010480 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 717785010481 Subunit III/VIIa interface [polypeptide binding]; other site 717785010482 Phospholipid binding site [chemical binding]; other site 717785010483 Subunit I/III interface [polypeptide binding]; other site 717785010484 Subunit III/VIb interface [polypeptide binding]; other site 717785010485 Subunit III/VIa interface; other site 717785010486 Subunit III/Vb interface [polypeptide binding]; other site 717785010487 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 717785010488 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 717785010489 UbiA prenyltransferase family; Region: UbiA; pfam01040 717785010490 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785010491 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 717785010492 Subunit I/III interface [polypeptide binding]; other site 717785010493 D-pathway; other site 717785010494 Subunit I/VIIc interface [polypeptide binding]; other site 717785010495 Subunit I/IV interface [polypeptide binding]; other site 717785010496 Subunit I/II interface [polypeptide binding]; other site 717785010497 Low-spin heme (heme a) binding site [chemical binding]; other site 717785010498 Subunit I/VIIa interface [polypeptide binding]; other site 717785010499 Subunit I/VIa interface [polypeptide binding]; other site 717785010500 Dimer interface; other site 717785010501 Putative water exit pathway; other site 717785010502 Binuclear center (heme a3/CuB) [ion binding]; other site 717785010503 K-pathway; other site 717785010504 Subunit I/Vb interface [polypeptide binding]; other site 717785010505 Putative proton exit pathway; other site 717785010506 Subunit I/VIb interface; other site 717785010507 Subunit I/VIc interface [polypeptide binding]; other site 717785010508 Electron transfer pathway; other site 717785010509 Subunit I/VIIIb interface [polypeptide binding]; other site 717785010510 Subunit I/VIIb interface [polypeptide binding]; other site 717785010511 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 717785010512 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 717785010513 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 717785010514 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785010515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785010516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785010517 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785010518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785010519 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785010520 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785010521 Protein of unknown function (DUF533); Region: DUF533; pfam04391 717785010522 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 717785010523 putative metal binding site [ion binding]; other site 717785010524 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785010525 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785010526 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785010527 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785010528 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785010529 Walker A/P-loop; other site 717785010530 ATP binding site [chemical binding]; other site 717785010531 Q-loop/lid; other site 717785010532 ABC transporter signature motif; other site 717785010533 Walker B; other site 717785010534 D-loop; other site 717785010535 H-loop/switch region; other site 717785010536 DevC protein; Region: devC; TIGR01185 717785010537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785010538 FtsX-like permease family; Region: FtsX; pfam02687 717785010539 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 717785010540 Esterase/lipase [General function prediction only]; Region: COG1647 717785010541 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 717785010542 aminodeoxychorismate synthase; Provisional; Region: PRK07508 717785010543 chorismate binding enzyme; Region: Chorismate_bind; cl10555 717785010544 hypothetical protein; Provisional; Region: PRK07546 717785010545 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 717785010546 substrate-cofactor binding pocket; other site 717785010547 homodimer interface [polypeptide binding]; other site 717785010548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010549 catalytic residue [active] 717785010550 2TM domain; Region: 2TM; pfam13239 717785010551 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 717785010552 nudix motif; other site 717785010553 Protein of unknown function (DUF763); Region: DUF763; pfam05559 717785010554 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785010555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 717785010556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785010557 Walker A/P-loop; other site 717785010558 ATP binding site [chemical binding]; other site 717785010559 Q-loop/lid; other site 717785010560 ABC transporter signature motif; other site 717785010561 Walker B; other site 717785010562 D-loop; other site 717785010563 H-loop/switch region; other site 717785010564 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 717785010565 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 717785010566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785010567 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 717785010568 putative ADP-binding pocket [chemical binding]; other site 717785010569 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 717785010570 Bacterial SH3 domain; Region: SH3_3; pfam08239 717785010571 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785010572 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 717785010573 active site 717785010574 Int/Topo IB signature motif; other site 717785010575 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 717785010576 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 717785010577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 717785010578 Homeodomain-like domain; Region: HTH_23; pfam13384 717785010579 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 717785010580 polymerase nucleotide-binding site; other site 717785010581 DNA-binding residues [nucleotide binding]; DNA binding site 717785010582 nucleotide binding site [chemical binding]; other site 717785010583 primase nucleotide-binding site [nucleotide binding]; other site 717785010584 AAA domain; Region: AAA_25; pfam13481 717785010585 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717785010586 Walker A motif; other site 717785010587 ATP binding site [chemical binding]; other site 717785010588 Walker B motif; other site 717785010589 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 717785010590 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 717785010591 active site 717785010592 Phage-related minor tail protein [Function unknown]; Region: COG5281 717785010593 tape measure domain; Region: tape_meas_nterm; TIGR02675 717785010594 Phage-related minor tail protein [Function unknown]; Region: COG5281 717785010595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785010596 non-specific DNA binding site [nucleotide binding]; other site 717785010597 salt bridge; other site 717785010598 sequence-specific DNA binding site [nucleotide binding]; other site 717785010599 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010601 putative substrate translocation pore; other site 717785010602 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 717785010603 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 717785010604 putative NAD(P) binding site [chemical binding]; other site 717785010605 putative substrate binding site [chemical binding]; other site 717785010606 catalytic Zn binding site [ion binding]; other site 717785010607 structural Zn binding site [ion binding]; other site 717785010608 dimer interface [polypeptide binding]; other site 717785010609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785010610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785010611 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785010612 putative effector binding pocket; other site 717785010613 putative dimerization interface [polypeptide binding]; other site 717785010614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785010615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785010616 active site 717785010617 catalytic tetrad [active] 717785010618 Protein of unknown function (DUF512); Region: DUF512; pfam04459 717785010619 dihydropteroate synthase-related protein; Region: TIGR00284 717785010620 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 717785010621 substrate binding pocket [chemical binding]; other site 717785010622 dimer interface [polypeptide binding]; other site 717785010623 inhibitor binding site; inhibition site 717785010624 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 717785010625 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 717785010626 active site 717785010627 SAM binding site [chemical binding]; other site 717785010628 homodimer interface [polypeptide binding]; other site 717785010629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785010630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785010631 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785010632 putative effector binding pocket; other site 717785010633 dimerization interface [polypeptide binding]; other site 717785010634 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 717785010635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785010636 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 717785010637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785010638 Zn binding site [ion binding]; other site 717785010639 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 717785010640 Zn binding site [ion binding]; other site 717785010641 putative hydrolase; Provisional; Region: PRK11460 717785010642 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 717785010643 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 717785010644 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 717785010645 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 717785010646 dimerization interface [polypeptide binding]; other site 717785010647 DPS ferroxidase diiron center [ion binding]; other site 717785010648 ion pore; other site 717785010649 Domain of unknown function DUF302; Region: DUF302; cl01364 717785010650 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 717785010651 classical (c) SDRs; Region: SDR_c; cd05233 717785010652 NAD(P) binding site [chemical binding]; other site 717785010653 active site 717785010654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785010655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785010656 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717785010657 CoenzymeA binding site [chemical binding]; other site 717785010658 subunit interaction site [polypeptide binding]; other site 717785010659 PHB binding site; other site 717785010660 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 717785010661 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785010662 dimer interface [polypeptide binding]; other site 717785010663 active site 717785010664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785010665 dimer interface [polypeptide binding]; other site 717785010666 conserved gate region; other site 717785010667 putative PBP binding loops; other site 717785010668 ABC-ATPase subunit interface; other site 717785010669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 717785010670 dimer interface [polypeptide binding]; other site 717785010671 conserved gate region; other site 717785010672 putative PBP binding loops; other site 717785010673 ABC-ATPase subunit interface; other site 717785010674 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 717785010675 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 717785010676 Walker A/P-loop; other site 717785010677 ATP binding site [chemical binding]; other site 717785010678 Q-loop/lid; other site 717785010679 ABC transporter signature motif; other site 717785010680 Walker B; other site 717785010681 D-loop; other site 717785010682 H-loop/switch region; other site 717785010683 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 717785010684 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 717785010685 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 717785010686 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 717785010687 catalytic triad [active] 717785010688 Sulfatase; Region: Sulfatase; cl17466 717785010689 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785010690 ligand binding site; other site 717785010691 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 717785010692 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 717785010693 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 717785010694 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 717785010695 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 717785010696 FHIPEP family; Region: FHIPEP; pfam00771 717785010697 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 717785010698 Rod binding protein; Region: Rod-binding; pfam10135 717785010699 Hemerythrin family; Region: Hemerythrin-like; cl15774 717785010700 CheD chemotactic sensory transduction; Region: CheD; cl00810 717785010701 Response regulator receiver domain; Region: Response_reg; pfam00072 717785010702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010703 active site 717785010704 phosphorylation site [posttranslational modification] 717785010705 intermolecular recognition site; other site 717785010706 dimerization interface [polypeptide binding]; other site 717785010707 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 717785010708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010709 active site 717785010710 phosphorylation site [posttranslational modification] 717785010711 intermolecular recognition site; other site 717785010712 dimerization interface [polypeptide binding]; other site 717785010713 CheB methylesterase; Region: CheB_methylest; pfam01339 717785010714 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785010715 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 717785010716 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 717785010717 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 717785010718 putative CheA interaction surface; other site 717785010719 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 717785010720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785010721 putative binding surface; other site 717785010722 active site 717785010723 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 717785010724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010725 ATP binding site [chemical binding]; other site 717785010726 Mg2+ binding site [ion binding]; other site 717785010727 G-X-G motif; other site 717785010728 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 717785010729 Response regulator receiver domain; Region: Response_reg; pfam00072 717785010730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010731 active site 717785010732 phosphorylation site [posttranslational modification] 717785010733 intermolecular recognition site; other site 717785010734 dimerization interface [polypeptide binding]; other site 717785010735 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 717785010736 anti sigma factor interaction site; other site 717785010737 regulatory phosphorylation site [posttranslational modification]; other site 717785010738 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 717785010739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717785010740 dimer interface [polypeptide binding]; other site 717785010741 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 717785010742 putative CheW interface [polypeptide binding]; other site 717785010743 PilZ domain; Region: PilZ; pfam07238 717785010744 PAS domain; Region: PAS_9; pfam13426 717785010745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785010746 putative active site [active] 717785010747 heme pocket [chemical binding]; other site 717785010748 PAS fold; Region: PAS_7; pfam12860 717785010749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785010750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010751 metal binding site [ion binding]; metal-binding site 717785010752 active site 717785010753 I-site; other site 717785010754 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785010755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 717785010756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010757 metal binding site [ion binding]; metal-binding site 717785010758 active site 717785010759 I-site; other site 717785010760 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 717785010761 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 717785010762 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 717785010763 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 717785010764 Flagellar protein FlaF; Region: FlaF; pfam07309 717785010765 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 717785010766 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717785010767 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 717785010768 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717785010769 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 717785010770 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717785010771 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 717785010772 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717785010773 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 717785010774 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717785010775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785010776 DNA binding site [nucleotide binding] 717785010777 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 717785010778 DUF2407 C-terminal domain; Region: DUF2407_C; pfam13373 717785010779 chemotaxis protein; Reviewed; Region: PRK12798 717785010780 flagellar motor protein MotB; Validated; Region: motB; PRK05996 717785010781 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 717785010782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785010783 ligand binding site [chemical binding]; other site 717785010784 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 717785010785 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 717785010786 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 717785010787 flagellin; Reviewed; Region: PRK12687 717785010788 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717785010789 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717785010790 FliP family; Region: FliP; cl00593 717785010791 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 717785010792 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 717785010793 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 717785010794 Uncharacterized conserved protein [Function unknown]; Region: COG3334 717785010795 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 717785010796 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 717785010797 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 717785010798 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 717785010799 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 717785010800 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717785010801 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 717785010802 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 717785010803 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717785010804 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 717785010805 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 717785010806 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 717785010807 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 717785010808 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 717785010809 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 717785010810 FliG C-terminal domain; Region: FliG_C; pfam01706 717785010811 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 717785010812 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 717785010813 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 717785010814 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 717785010815 flagellar motor protein MotA; Validated; Region: PRK09110 717785010816 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 717785010817 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 717785010818 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 717785010819 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 717785010820 Walker A motif; other site 717785010821 ATP binding site [chemical binding]; other site 717785010822 Walker B motif; other site 717785010823 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 717785010824 catalytic residue [active] 717785010825 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785010826 FOG: CBS domain [General function prediction only]; Region: COG0517 717785010827 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 717785010828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785010829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785010830 LysR substrate binding domain; Region: LysR_substrate; pfam03466 717785010831 dimerization interface [polypeptide binding]; other site 717785010832 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 717785010833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 717785010834 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 717785010835 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 717785010836 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 717785010837 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785010838 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785010839 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785010840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785010841 non-specific DNA binding site [nucleotide binding]; other site 717785010842 salt bridge; other site 717785010843 sequence-specific DNA binding site [nucleotide binding]; other site 717785010844 Cupin domain; Region: Cupin_2; pfam07883 717785010845 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 717785010846 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 717785010847 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 717785010848 putative active site [active] 717785010849 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 717785010850 domain_subunit interface; other site 717785010851 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 717785010852 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 717785010853 active site 717785010854 FMN binding site [chemical binding]; other site 717785010855 substrate binding site [chemical binding]; other site 717785010856 3Fe-4S cluster binding site [ion binding]; other site 717785010857 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 717785010858 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785010859 Uncharacterized conserved protein [Function unknown]; Region: COG3287 717785010860 FIST N domain; Region: FIST; pfam08495 717785010861 FIST C domain; Region: FIST_C; pfam10442 717785010862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785010863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785010864 dimer interface [polypeptide binding]; other site 717785010865 phosphorylation site [posttranslational modification] 717785010866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010867 ATP binding site [chemical binding]; other site 717785010868 Mg2+ binding site [ion binding]; other site 717785010869 G-X-G motif; other site 717785010870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785010871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010872 active site 717785010873 phosphorylation site [posttranslational modification] 717785010874 intermolecular recognition site; other site 717785010875 dimerization interface [polypeptide binding]; other site 717785010876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785010877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010878 active site 717785010879 phosphorylation site [posttranslational modification] 717785010880 intermolecular recognition site; other site 717785010881 dimerization interface [polypeptide binding]; other site 717785010882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785010883 DNA binding residues [nucleotide binding] 717785010884 dimerization interface [polypeptide binding]; other site 717785010885 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 717785010886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785010887 nucleotide binding region [chemical binding]; other site 717785010888 ATP-binding site [chemical binding]; other site 717785010889 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 717785010890 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 717785010891 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 717785010892 substrate binding site [chemical binding]; other site 717785010893 hexamer interface [polypeptide binding]; other site 717785010894 metal binding site [ion binding]; metal-binding site 717785010895 phosphoribulokinase; Provisional; Region: PRK15453 717785010896 active site 717785010897 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 717785010898 AMP binding site [chemical binding]; other site 717785010899 metal binding site [ion binding]; metal-binding site 717785010900 active site 717785010901 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 717785010902 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 717785010903 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785010904 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785010905 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785010906 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 717785010907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 717785010908 Uncharacterized conserved protein [Function unknown]; Region: COG2308 717785010909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785010911 putative substrate translocation pore; other site 717785010912 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 717785010913 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 717785010914 Potassium binding sites [ion binding]; other site 717785010915 Cesium cation binding sites [ion binding]; other site 717785010916 Ion channel; Region: Ion_trans_2; pfam07885 717785010917 Ion transport protein; Region: Ion_trans; pfam00520 717785010918 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785010919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785010920 ligand binding site [chemical binding]; other site 717785010921 flexible hinge region; other site 717785010922 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 717785010923 active site 717785010924 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 717785010925 phosphopeptide binding site; other site 717785010926 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 717785010927 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 717785010928 phosphopeptide binding site; other site 717785010929 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 717785010930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785010931 active site 717785010932 ATP binding site [chemical binding]; other site 717785010933 substrate binding site [chemical binding]; other site 717785010934 activation loop (A-loop); other site 717785010935 FOG: WD40 repeat [General function prediction only]; Region: COG2319 717785010936 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 717785010937 structural tetrad; other site 717785010938 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 717785010939 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785010940 Catalytic site; other site 717785010941 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 717785010942 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 717785010943 putative di-iron ligands [ion binding]; other site 717785010944 HemK family putative methylases; Region: hemK_fam; TIGR00536 717785010945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785010946 S-adenosylmethionine binding site [chemical binding]; other site 717785010947 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 717785010948 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 717785010949 CoA binding domain; Region: CoA_binding; smart00881 717785010950 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010951 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 717785010952 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 717785010953 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010954 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 717785010955 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 717785010956 homodimer interface [polypeptide binding]; other site 717785010957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010958 catalytic residue [active] 717785010959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785010960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785010961 active site 717785010962 phosphorylation site [posttranslational modification] 717785010963 intermolecular recognition site; other site 717785010964 dimerization interface [polypeptide binding]; other site 717785010965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785010966 dimerization interface [polypeptide binding]; other site 717785010967 DNA binding residues [nucleotide binding] 717785010968 Fusaric acid resistance protein family; Region: FUSC; pfam04632 717785010969 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 717785010970 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 717785010971 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 717785010972 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 717785010973 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785010974 Catalytic site; other site 717785010975 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785010976 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 717785010977 Ferredoxin [Energy production and conversion]; Region: COG1146 717785010978 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 717785010979 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 717785010980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785010981 RNA binding surface [nucleotide binding]; other site 717785010982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785010983 ATP binding site [chemical binding]; other site 717785010984 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 717785010985 putative Mg++ binding site [ion binding]; other site 717785010986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785010987 nucleotide binding region [chemical binding]; other site 717785010988 ATP-binding site [chemical binding]; other site 717785010989 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 717785010990 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 717785010991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 717785010992 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 717785010993 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 717785010994 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 717785010995 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 717785010996 metal ion-dependent adhesion site (MIDAS); other site 717785010997 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 717785010998 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 717785010999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 717785011000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785011001 HSP70 interaction site [polypeptide binding]; other site 717785011002 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 717785011003 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 717785011004 Domain of unknown function DUF21; Region: DUF21; pfam01595 717785011005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785011006 Transporter associated domain; Region: CorC_HlyC; smart01091 717785011007 shikimate kinase; Provisional; Region: PRK13946 717785011008 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 717785011009 ADP binding site [chemical binding]; other site 717785011010 magnesium binding site [ion binding]; other site 717785011011 putative shikimate binding site; other site 717785011012 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 717785011013 active site 717785011014 dimer interface [polypeptide binding]; other site 717785011015 metal binding site [ion binding]; metal-binding site 717785011016 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 717785011017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785011018 active site 717785011019 DNA binding site [nucleotide binding] 717785011020 Int/Topo IB signature motif; other site 717785011021 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 717785011022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011023 putative substrate translocation pore; other site 717785011024 POT family; Region: PTR2; cl17359 717785011025 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 717785011026 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 717785011027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785011028 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 717785011029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785011030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785011031 hypothetical protein; Provisional; Region: PRK05208 717785011032 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 717785011033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 717785011034 ATP binding site [chemical binding]; other site 717785011035 putative Mg++ binding site [ion binding]; other site 717785011036 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 717785011037 SEC-C motif; Region: SEC-C; pfam02810 717785011038 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 717785011039 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 717785011040 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 717785011041 heterotetramer interface [polypeptide binding]; other site 717785011042 active site pocket [active] 717785011043 cleavage site 717785011044 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 717785011045 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 717785011046 active site 717785011047 8-oxo-dGMP binding site [chemical binding]; other site 717785011048 nudix motif; other site 717785011049 metal binding site [ion binding]; metal-binding site 717785011050 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785011051 Methyltransferase domain; Region: Methyltransf_11; pfam08241 717785011052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 717785011053 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 717785011054 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 717785011055 GSH binding site [chemical binding]; other site 717785011056 catalytic residues [active] 717785011057 nitrilase; Region: PLN02798 717785011058 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 717785011059 putative active site [active] 717785011060 catalytic triad [active] 717785011061 dimer interface [polypeptide binding]; other site 717785011062 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 717785011063 biotin synthase; Region: bioB; TIGR00433 717785011064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785011065 FeS/SAM binding site; other site 717785011066 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 717785011067 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 717785011068 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 717785011069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785011070 catalytic residue [active] 717785011071 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 717785011072 AAA domain; Region: AAA_26; pfam13500 717785011073 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 717785011074 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 717785011075 inhibitor-cofactor binding pocket; inhibition site 717785011076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785011077 catalytic residue [active] 717785011078 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 717785011079 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785011080 dimer interface [polypeptide binding]; other site 717785011081 active site 717785011082 CoA binding pocket [chemical binding]; other site 717785011083 YceI-like domain; Region: YceI; cl01001 717785011084 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 717785011085 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785011086 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785011087 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785011088 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 717785011089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 717785011090 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 717785011091 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785011092 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785011093 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 717785011094 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 717785011095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 717785011096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 717785011097 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 717785011098 Hemin uptake protein hemP; Region: hemP; pfam10636 717785011099 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 717785011100 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 717785011101 intersubunit interface [polypeptide binding]; other site 717785011102 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 717785011103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 717785011104 ABC-ATPase subunit interface; other site 717785011105 dimer interface [polypeptide binding]; other site 717785011106 putative PBP binding regions; other site 717785011107 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 717785011108 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 717785011109 Walker A/P-loop; other site 717785011110 ATP binding site [chemical binding]; other site 717785011111 Q-loop/lid; other site 717785011112 ABC transporter signature motif; other site 717785011113 Walker B; other site 717785011114 D-loop; other site 717785011115 H-loop/switch region; other site 717785011116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785011117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 717785011118 active site 717785011119 metal binding site [ion binding]; metal-binding site 717785011120 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 717785011121 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 717785011122 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 717785011123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011124 ATP binding site [chemical binding]; other site 717785011125 Mg2+ binding site [ion binding]; other site 717785011126 G-X-G motif; other site 717785011127 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 717785011128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011129 active site 717785011130 phosphorylation site [posttranslational modification] 717785011131 intermolecular recognition site; other site 717785011132 dimerization interface [polypeptide binding]; other site 717785011133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785011134 DNA binding site [nucleotide binding] 717785011135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011136 Uncharacterized conserved protein [Function unknown]; Region: COG1432 717785011137 LabA_like proteins; Region: LabA; cd10911 717785011138 putative metal binding site [ion binding]; other site 717785011139 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785011140 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785011141 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785011142 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785011143 Predicted transporter component [General function prediction only]; Region: COG2391 717785011144 Sulphur transport; Region: Sulf_transp; pfam04143 717785011145 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 717785011146 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 717785011147 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 717785011148 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 717785011149 Predicted integral membrane protein [Function unknown]; Region: COG0392 717785011150 Uncharacterized conserved protein [Function unknown]; Region: COG2898 717785011151 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 717785011152 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 717785011153 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 717785011154 PilZ domain; Region: PilZ; pfam07238 717785011155 Response regulator receiver domain; Region: Response_reg; pfam00072 717785011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011157 active site 717785011158 phosphorylation site [posttranslational modification] 717785011159 intermolecular recognition site; other site 717785011160 dimerization interface [polypeptide binding]; other site 717785011161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785011162 metal binding site [ion binding]; metal-binding site 717785011163 active site 717785011164 I-site; other site 717785011165 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785011166 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 717785011167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011168 active site 717785011169 phosphorylation site [posttranslational modification] 717785011170 intermolecular recognition site; other site 717785011171 dimerization interface [polypeptide binding]; other site 717785011172 CheB methylesterase; Region: CheB_methylest; pfam01339 717785011173 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785011174 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 717785011175 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 717785011176 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 717785011177 putative CheA interaction surface; other site 717785011178 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 717785011179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 717785011180 dimerization interface [polypeptide binding]; other site 717785011181 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717785011182 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 717785011183 dimer interface [polypeptide binding]; other site 717785011184 putative CheW interface [polypeptide binding]; other site 717785011185 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 717785011186 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 717785011187 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785011188 putative binding surface; other site 717785011189 active site 717785011190 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 717785011191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011192 ATP binding site [chemical binding]; other site 717785011193 Mg2+ binding site [ion binding]; other site 717785011194 G-X-G motif; other site 717785011195 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 717785011196 Response regulator receiver domain; Region: Response_reg; pfam00072 717785011197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011198 active site 717785011199 phosphorylation site [posttranslational modification] 717785011200 intermolecular recognition site; other site 717785011201 dimerization interface [polypeptide binding]; other site 717785011202 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 717785011203 mce related protein; Region: MCE; pfam02470 717785011204 Protein of unknown function (DUF330); Region: DUF330; cl01135 717785011205 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 717785011206 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 717785011207 Walker A/P-loop; other site 717785011208 ATP binding site [chemical binding]; other site 717785011209 Q-loop/lid; other site 717785011210 ABC transporter signature motif; other site 717785011211 Walker B; other site 717785011212 D-loop; other site 717785011213 H-loop/switch region; other site 717785011214 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 717785011215 anti sigma factor interaction site; other site 717785011216 regulatory phosphorylation site [posttranslational modification]; other site 717785011217 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 717785011218 Permease; Region: Permease; pfam02405 717785011219 YGGT family; Region: YGGT; pfam02325 717785011220 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 717785011221 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 717785011222 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 717785011223 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 717785011224 homodimer interface [polypeptide binding]; other site 717785011225 NADP binding site [chemical binding]; other site 717785011226 substrate binding site [chemical binding]; other site 717785011227 KTSC domain; Region: KTSC; pfam13619 717785011228 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 717785011229 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 717785011230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785011231 Walker A motif; other site 717785011232 ATP binding site [chemical binding]; other site 717785011233 Walker B motif; other site 717785011234 arginine finger; other site 717785011235 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 717785011236 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 717785011237 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 717785011238 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 717785011239 active site 717785011240 glutathione synthetase; Provisional; Region: PRK05246 717785011241 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 717785011242 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 717785011243 primosome assembly protein PriA; Validated; Region: PRK05580 717785011244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785011245 ATP binding site [chemical binding]; other site 717785011246 putative Mg++ binding site [ion binding]; other site 717785011247 helicase superfamily c-terminal domain; Region: HELICc; smart00490 717785011248 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 717785011249 active site 717785011250 intersubunit interactions; other site 717785011251 catalytic residue [active] 717785011252 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 717785011253 FAD binding domain; Region: FAD_binding_4; pfam01565 717785011254 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 717785011255 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785011256 active site 717785011257 DNA binding site [nucleotide binding] 717785011258 Int/Topo IB signature motif; other site 717785011259 TraB family; Region: TraB; cl12050 717785011260 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 717785011261 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 717785011262 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 717785011263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785011264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785011265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785011266 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 717785011267 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785011268 E3 interaction surface; other site 717785011269 lipoyl attachment site [posttranslational modification]; other site 717785011270 e3 binding domain; Region: E3_binding; pfam02817 717785011271 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 717785011272 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 717785011273 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 717785011274 TPP-binding site [chemical binding]; other site 717785011275 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 717785011276 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 717785011277 CoA binding domain; Region: CoA_binding; smart00881 717785011278 CoA-ligase; Region: Ligase_CoA; pfam00549 717785011279 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 717785011280 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 717785011281 CoA-ligase; Region: Ligase_CoA; pfam00549 717785011282 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 717785011283 malate dehydrogenase; Reviewed; Region: PRK06223 717785011284 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 717785011285 NAD(P) binding site [chemical binding]; other site 717785011286 dimer interface [polypeptide binding]; other site 717785011287 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785011288 substrate binding site [chemical binding]; other site 717785011289 Predicted ATPase [General function prediction only]; Region: COG1485 717785011290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 717785011291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785011292 Coenzyme A binding pocket [chemical binding]; other site 717785011293 TIGR02594 family protein; Region: TIGR02594 717785011294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 717785011295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785011296 active site 717785011297 catalytic tetrad [active] 717785011298 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 717785011299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 717785011300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785011301 catalytic residue [active] 717785011302 Domain of unknown function (DUF336); Region: DUF336; pfam03928 717785011303 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 717785011304 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 717785011305 HIGH motif; other site 717785011306 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 717785011307 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785011308 active site 717785011309 KMSKS motif; other site 717785011310 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 717785011311 tRNA binding surface [nucleotide binding]; other site 717785011312 Lipopolysaccharide-assembly; Region: LptE; cl01125 717785011313 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 717785011314 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 717785011315 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 717785011316 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 717785011317 substrate binding site [chemical binding]; other site 717785011318 ATP binding site [chemical binding]; other site 717785011319 pantothenate kinase; Provisional; Region: PRK05439 717785011320 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 717785011321 ATP-binding site [chemical binding]; other site 717785011322 CoA-binding site [chemical binding]; other site 717785011323 Mg2+-binding site [ion binding]; other site 717785011324 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 717785011325 metal binding site [ion binding]; metal-binding site 717785011326 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 717785011327 ParB-like nuclease domain; Region: ParB; smart00470 717785011328 KorB domain; Region: KorB; pfam08535 717785011329 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785011330 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785011331 P-loop; other site 717785011332 Magnesium ion binding site [ion binding]; other site 717785011333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 717785011334 Magnesium ion binding site [ion binding]; other site 717785011335 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 717785011336 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 717785011337 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 717785011338 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 717785011339 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 717785011340 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 717785011341 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785011342 trmE is a tRNA modification GTPase; Region: trmE; cd04164 717785011343 G1 box; other site 717785011344 GTP/Mg2+ binding site [chemical binding]; other site 717785011345 Switch I region; other site 717785011346 G2 box; other site 717785011347 Switch II region; other site 717785011348 G3 box; other site 717785011349 G4 box; other site 717785011350 G5 box; other site 717785011351 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 717785011352 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 717785011353 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 717785011354 catalytic residues [active] 717785011355 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 717785011356 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 717785011357 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 717785011358 transcription termination factor Rho; Provisional; Region: rho; PRK09376 717785011359 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 717785011360 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 717785011361 RNA binding site [nucleotide binding]; other site 717785011362 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 717785011363 multimer interface [polypeptide binding]; other site 717785011364 Walker A motif; other site 717785011365 ATP binding site [chemical binding]; other site 717785011366 Walker B motif; other site 717785011367 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 717785011368 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 717785011369 substrate binding site [chemical binding]; other site 717785011370 active site 717785011371 PEP synthetase regulatory protein; Provisional; Region: PRK05339 717785011372 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 717785011373 active site 717785011374 dimer interface [polypeptide binding]; other site 717785011375 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 717785011376 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 717785011377 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 717785011378 shikimate binding site; other site 717785011379 NAD(P) binding site [chemical binding]; other site 717785011380 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 717785011381 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 717785011382 CoA-binding site [chemical binding]; other site 717785011383 ATP-binding [chemical binding]; other site 717785011384 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 717785011385 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 717785011386 active site 717785011387 catalytic site [active] 717785011388 substrate binding site [chemical binding]; other site 717785011389 Preprotein translocase subunit SecB; Region: SecB; pfam02556 717785011390 SecA binding site; other site 717785011391 Preprotein binding site; other site 717785011392 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 717785011393 Tim44-like domain; Region: Tim44; pfam04280 717785011394 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 717785011395 MltA specific insert domain; Region: MltA; pfam03562 717785011396 3D domain; Region: 3D; pfam06725 717785011397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 717785011398 Smr domain; Region: Smr; pfam01713 717785011399 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785011400 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 717785011401 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 717785011402 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 717785011403 NAD(P) binding site [chemical binding]; other site 717785011404 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 717785011405 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 717785011406 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 717785011407 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 717785011408 active site 717785011409 catalytic triad [active] 717785011410 oxyanion hole [active] 717785011411 switch loop; other site 717785011412 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 717785011413 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 717785011414 Walker A/P-loop; other site 717785011415 ATP binding site [chemical binding]; other site 717785011416 Q-loop/lid; other site 717785011417 ABC transporter signature motif; other site 717785011418 Walker B; other site 717785011419 D-loop; other site 717785011420 H-loop/switch region; other site 717785011421 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 717785011422 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785011423 FtsX-like permease family; Region: FtsX; pfam02687 717785011424 FtsX-like permease family; Region: FtsX; pfam02687 717785011425 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 717785011426 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 717785011427 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 717785011428 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 717785011429 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 717785011430 active site 717785011431 Zn binding site [ion binding]; other site 717785011432 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 717785011433 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 717785011434 Protein of unknown function (DUF525); Region: DUF525; cl01119 717785011435 aconitate hydratase; Validated; Region: PRK09277 717785011436 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 717785011437 substrate binding site [chemical binding]; other site 717785011438 ligand binding site [chemical binding]; other site 717785011439 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 717785011440 substrate binding site [chemical binding]; other site 717785011441 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 717785011442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 717785011443 Walker A/P-loop; other site 717785011444 ATP binding site [chemical binding]; other site 717785011445 Q-loop/lid; other site 717785011446 ABC transporter signature motif; other site 717785011447 Walker B; other site 717785011448 D-loop; other site 717785011449 H-loop/switch region; other site 717785011450 heme exporter protein CcmB; Region: ccmB; TIGR01190 717785011451 heme exporter protein CcmC; Region: ccmC; TIGR01191 717785011452 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 717785011453 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 717785011454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785011455 catalytic residues [active] 717785011456 central insert; other site 717785011457 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 717785011458 active site clefts [active] 717785011459 zinc binding site [ion binding]; other site 717785011460 dimer interface [polypeptide binding]; other site 717785011461 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 717785011462 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 717785011463 dimer interface [polypeptide binding]; other site 717785011464 pyridoxal binding site [chemical binding]; other site 717785011465 ATP binding site [chemical binding]; other site 717785011466 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 717785011467 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 717785011468 putative active site [active] 717785011469 putative catalytic site [active] 717785011470 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 717785011471 putative active site [active] 717785011472 putative catalytic site [active] 717785011473 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 717785011474 E-class dimer interface [polypeptide binding]; other site 717785011475 P-class dimer interface [polypeptide binding]; other site 717785011476 active site 717785011477 Cu2+ binding site [ion binding]; other site 717785011478 Zn2+ binding site [ion binding]; other site 717785011479 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 717785011480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785011481 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 717785011482 Iron-sulfur protein interface; other site 717785011483 proximal quinone binding site [chemical binding]; other site 717785011484 SdhD (CybS) interface [polypeptide binding]; other site 717785011485 proximal heme binding site [chemical binding]; other site 717785011486 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 717785011487 putative SdhC subunit interface [polypeptide binding]; other site 717785011488 putative proximal heme binding site [chemical binding]; other site 717785011489 putative Iron-sulfur protein interface [polypeptide binding]; other site 717785011490 putative proximal quinone binding site; other site 717785011491 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 717785011492 L-aspartate oxidase; Provisional; Region: PRK06175 717785011493 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 717785011494 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 717785011495 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 717785011496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785011497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 717785011498 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 717785011499 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 717785011500 Helix-turn-helix domain; Region: HTH_18; pfam12833 717785011501 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 717785011502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785011503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785011504 homodimer interface [polypeptide binding]; other site 717785011505 catalytic residue [active] 717785011506 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 717785011507 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 717785011508 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 717785011509 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 717785011510 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 717785011511 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 717785011512 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785011513 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785011514 ligand binding site [chemical binding]; other site 717785011515 flexible hinge region; other site 717785011516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785011517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011518 active site 717785011519 phosphorylation site [posttranslational modification] 717785011520 intermolecular recognition site; other site 717785011521 dimerization interface [polypeptide binding]; other site 717785011522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 717785011523 DNA binding site [nucleotide binding] 717785011524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 717785011525 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 717785011526 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 717785011527 Nitrogen regulatory protein P-II; Region: P-II; smart00938 717785011528 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 717785011529 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 717785011530 active site 717785011531 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 717785011532 catalytic triad [active] 717785011533 dimer interface [polypeptide binding]; other site 717785011534 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 717785011535 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 717785011536 RimM N-terminal domain; Region: RimM; pfam01782 717785011537 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 717785011538 PRC-barrel domain; Region: PRC; pfam05239 717785011539 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 717785011540 signal recognition particle protein; Provisional; Region: PRK10867 717785011541 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 717785011542 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717785011543 P loop; other site 717785011544 GTP binding site [chemical binding]; other site 717785011545 Signal peptide binding domain; Region: SRP_SPB; pfam02978 717785011546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 717785011547 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 717785011548 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 717785011549 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 717785011550 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 717785011551 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 717785011552 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 717785011553 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785011554 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785011555 FeS/SAM binding site; other site 717785011556 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 717785011557 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 717785011558 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717785011559 P loop; other site 717785011560 GTP binding site [chemical binding]; other site 717785011561 Intracellular septation protein A; Region: IspA; pfam04279 717785011562 Intracellular septation protein A; Region: IspA; pfam04279 717785011563 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785011564 MarR family; Region: MarR_2; pfam12802 717785011565 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 717785011566 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 717785011567 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 717785011568 tartrate dehydrogenase; Region: TTC; TIGR02089 717785011569 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 717785011570 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 717785011571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785011572 catalytic core [active] 717785011573 dihydrodipicolinate reductase; Provisional; Region: PRK00048 717785011574 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 717785011575 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 717785011576 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 717785011577 dimer interface [polypeptide binding]; other site 717785011578 substrate binding site [chemical binding]; other site 717785011579 metal binding sites [ion binding]; metal-binding site 717785011580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 717785011581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785011582 Coenzyme A binding pocket [chemical binding]; other site 717785011583 Phasin protein; Region: Phasin_2; cl11491 717785011584 PIF1-like helicase; Region: PIF1; pfam05970 717785011585 AAA domain; Region: AAA_30; pfam13604 717785011586 Family description; Region: UvrD_C_2; pfam13538 717785011587 Helicase; Region: Herpes_Helicase; pfam02689 717785011588 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 717785011589 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 717785011590 G1 box; other site 717785011591 putative GEF interaction site [polypeptide binding]; other site 717785011592 GTP/Mg2+ binding site [chemical binding]; other site 717785011593 Switch I region; other site 717785011594 G2 box; other site 717785011595 G3 box; other site 717785011596 Switch II region; other site 717785011597 G4 box; other site 717785011598 G5 box; other site 717785011599 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 717785011600 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 717785011601 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 717785011602 Peptidase family M50; Region: Peptidase_M50; pfam02163 717785011603 active site 717785011604 putative substrate binding region [chemical binding]; other site 717785011605 molybdenum-pterin binding domain; Region: Mop; TIGR00638 717785011606 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 717785011607 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 717785011608 putative active site; other site 717785011609 catalytic triad [active] 717785011610 putative dimer interface [polypeptide binding]; other site 717785011611 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 717785011612 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 717785011613 Fic family protein [Function unknown]; Region: COG3177 717785011614 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 717785011615 Fic/DOC family; Region: Fic; pfam02661 717785011616 argininosuccinate synthase; Provisional; Region: PRK13820 717785011617 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 717785011618 ANP binding site [chemical binding]; other site 717785011619 Substrate Binding Site II [chemical binding]; other site 717785011620 Substrate Binding Site I [chemical binding]; other site 717785011621 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 717785011622 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 717785011623 putative catalytic residue [active] 717785011624 acyl-CoA synthetase; Provisional; Region: PTZ00216 717785011625 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 717785011626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785011627 FeS/SAM binding site; other site 717785011628 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 717785011629 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 717785011630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785011631 Walker A motif; other site 717785011632 ATP binding site [chemical binding]; other site 717785011633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785011634 Walker B motif; other site 717785011635 arginine finger; other site 717785011636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 717785011637 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 717785011638 active site 717785011639 HslU subunit interaction site [polypeptide binding]; other site 717785011640 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 717785011641 putative active site pocket [active] 717785011642 4-fold oligomerization interface [polypeptide binding]; other site 717785011643 metal binding residues [ion binding]; metal-binding site 717785011644 3-fold/trimer interface [polypeptide binding]; other site 717785011645 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 717785011646 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 717785011647 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 717785011648 putative active site [active] 717785011649 oxyanion strand; other site 717785011650 catalytic triad [active] 717785011651 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 717785011652 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 717785011653 catalytic residues [active] 717785011654 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 717785011655 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 717785011656 G1 box; other site 717785011657 putative GEF interaction site [polypeptide binding]; other site 717785011658 GTP/Mg2+ binding site [chemical binding]; other site 717785011659 Switch I region; other site 717785011660 G2 box; other site 717785011661 G3 box; other site 717785011662 Switch II region; other site 717785011663 G4 box; other site 717785011664 G5 box; other site 717785011665 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 717785011666 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 717785011667 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 717785011668 substrate binding site [chemical binding]; other site 717785011669 glutamase interaction surface [polypeptide binding]; other site 717785011670 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 717785011671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785011672 minor groove reading motif; other site 717785011673 helix-hairpin-helix signature motif; other site 717785011674 substrate binding pocket [chemical binding]; other site 717785011675 active site 717785011676 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 717785011677 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 717785011678 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 717785011679 dimer interface [polypeptide binding]; other site 717785011680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785011681 active site 717785011682 metal binding site [ion binding]; metal-binding site 717785011683 glutathione binding site [chemical binding]; other site 717785011684 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 717785011685 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 717785011686 substrate binding site [chemical binding]; other site 717785011687 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 717785011688 Methyltransferase domain; Region: Methyltransf_23; pfam13489 717785011689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785011690 S-adenosylmethionine binding site [chemical binding]; other site 717785011691 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 717785011692 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 717785011693 substrate binding site [chemical binding]; other site 717785011694 ligand binding site [chemical binding]; other site 717785011695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785011696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785011697 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785011698 putative effector binding pocket; other site 717785011699 dimerization interface [polypeptide binding]; other site 717785011700 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 717785011701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785011702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785011703 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 717785011704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011705 putative substrate translocation pore; other site 717785011706 hypothetical protein; Reviewed; Region: PRK00024 717785011707 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 717785011708 MPN+ (JAMM) motif; other site 717785011709 Zinc-binding site [ion binding]; other site 717785011710 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 717785011711 active site 717785011712 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 717785011713 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785011714 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785011715 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 717785011716 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 717785011717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785011718 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 717785011719 active site 717785011720 dimer interface [polypeptide binding]; other site 717785011721 Predicted flavoprotein [General function prediction only]; Region: COG0431 717785011722 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 717785011723 chaperone protein DnaJ; Provisional; Region: PRK10767 717785011724 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 717785011725 HSP70 interaction site [polypeptide binding]; other site 717785011726 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 717785011727 substrate binding site [polypeptide binding]; other site 717785011728 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 717785011729 Zn binding sites [ion binding]; other site 717785011730 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 717785011731 dimer interface [polypeptide binding]; other site 717785011732 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 717785011733 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 717785011734 nucleotide binding site [chemical binding]; other site 717785011735 NEF interaction site [polypeptide binding]; other site 717785011736 SBD interface [polypeptide binding]; other site 717785011737 heat shock protein GrpE; Provisional; Region: PRK14141 717785011738 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 717785011739 dimer interface [polypeptide binding]; other site 717785011740 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 717785011741 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 717785011742 ribonuclease PH; Reviewed; Region: rph; PRK00173 717785011743 Ribonuclease PH; Region: RNase_PH_bact; cd11362 717785011744 hexamer interface [polypeptide binding]; other site 717785011745 active site 717785011746 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 717785011747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 717785011748 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 717785011749 putative metal binding site [ion binding]; other site 717785011750 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 717785011751 active site 717785011752 dimerization interface [polypeptide binding]; other site 717785011753 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 717785011754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785011755 FeS/SAM binding site; other site 717785011756 HemN C-terminal domain; Region: HemN_C; pfam06969 717785011757 Predicted membrane protein [Function unknown]; Region: COG1238 717785011758 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 717785011759 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 717785011760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 717785011761 active site 717785011762 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785011763 endonuclease III; Region: ENDO3c; smart00478 717785011764 minor groove reading motif; other site 717785011765 helix-hairpin-helix signature motif; other site 717785011766 substrate binding pocket [chemical binding]; other site 717785011767 active site 717785011768 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 717785011769 active site 717785011770 HIGH motif; other site 717785011771 nucleotide binding site [chemical binding]; other site 717785011772 active site 717785011773 KMSKS motif; other site 717785011774 Predicted methyltransferases [General function prediction only]; Region: COG0313 717785011775 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 717785011776 putative SAM binding site [chemical binding]; other site 717785011777 putative homodimer interface [polypeptide binding]; other site 717785011778 hypothetical protein; Reviewed; Region: PRK12497 717785011779 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 717785011780 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 717785011781 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 717785011782 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785011783 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 717785011784 beta subunit interaction interface [polypeptide binding]; other site 717785011785 Walker A motif; other site 717785011786 ATP binding site [chemical binding]; other site 717785011787 Walker B motif; other site 717785011788 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785011789 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 717785011790 core domain interface [polypeptide binding]; other site 717785011791 delta subunit interface [polypeptide binding]; other site 717785011792 epsilon subunit interface [polypeptide binding]; other site 717785011793 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 717785011794 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 717785011795 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785011796 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 717785011797 alpha subunit interaction interface [polypeptide binding]; other site 717785011798 Walker A motif; other site 717785011799 ATP binding site [chemical binding]; other site 717785011800 Walker B motif; other site 717785011801 inhibitor binding site; inhibition site 717785011802 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785011803 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 717785011804 gamma subunit interface [polypeptide binding]; other site 717785011805 epsilon subunit interface [polypeptide binding]; other site 717785011806 LBP interface [polypeptide binding]; other site 717785011807 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 717785011808 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 717785011809 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 717785011810 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785011811 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 717785011812 D-pathway; other site 717785011813 Putative ubiquinol binding site [chemical binding]; other site 717785011814 Low-spin heme (heme b) binding site [chemical binding]; other site 717785011815 Putative water exit pathway; other site 717785011816 Binuclear center (heme o3/CuB) [ion binding]; other site 717785011817 K-pathway; other site 717785011818 Putative proton exit pathway; other site 717785011819 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 717785011820 Subunit I/III interface [polypeptide binding]; other site 717785011821 Subunit III/IV interface [polypeptide binding]; other site 717785011822 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 717785011823 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 717785011824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785011825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 717785011826 dimer interface [polypeptide binding]; other site 717785011827 phosphorylation site [posttranslational modification] 717785011828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011829 ATP binding site [chemical binding]; other site 717785011830 Mg2+ binding site [ion binding]; other site 717785011831 G-X-G motif; other site 717785011832 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 717785011833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785011834 active site 717785011835 phosphorylation site [posttranslational modification] 717785011836 intermolecular recognition site; other site 717785011837 dimerization interface [polypeptide binding]; other site 717785011838 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 717785011839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785011840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785011841 dimer interface [polypeptide binding]; other site 717785011842 phosphorylation site [posttranslational modification] 717785011843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011844 ATP binding site [chemical binding]; other site 717785011845 Mg2+ binding site [ion binding]; other site 717785011846 G-X-G motif; other site 717785011847 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 717785011848 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 717785011849 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 717785011850 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 717785011851 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 717785011852 Flavoprotein; Region: Flavoprotein; pfam02441 717785011853 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 717785011854 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 717785011855 trimer interface [polypeptide binding]; other site 717785011856 active site 717785011857 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 717785011858 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 717785011859 dimer interface [polypeptide binding]; other site 717785011860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785011861 catalytic residue [active] 717785011862 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 717785011863 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 717785011864 ATP binding site [chemical binding]; other site 717785011865 substrate interface [chemical binding]; other site 717785011866 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 717785011867 Peptidase family M50; Region: Peptidase_M50; pfam02163 717785011868 putative substrate binding region [chemical binding]; other site 717785011869 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 717785011870 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 717785011871 dimerization interface [polypeptide binding]; other site 717785011872 ligand binding site [chemical binding]; other site 717785011873 NADP binding site [chemical binding]; other site 717785011874 catalytic site [active] 717785011875 Bacterial SH3 domain; Region: SH3_4; pfam06347 717785011876 Bacterial SH3 domain; Region: SH3_4; pfam06347 717785011877 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785011878 metal binding site 2 [ion binding]; metal-binding site 717785011879 putative DNA binding helix; other site 717785011880 metal binding site 1 [ion binding]; metal-binding site 717785011881 dimer interface [polypeptide binding]; other site 717785011882 structural Zn2+ binding site [ion binding]; other site 717785011883 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 717785011884 active site 2 [active] 717785011885 active site 1 [active] 717785011886 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 717785011887 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785011888 dimer interface [polypeptide binding]; other site 717785011889 active site 717785011890 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 717785011891 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785011892 NAD binding site [chemical binding]; other site 717785011893 homotetramer interface [polypeptide binding]; other site 717785011894 homodimer interface [polypeptide binding]; other site 717785011895 substrate binding site [chemical binding]; other site 717785011896 active site 717785011897 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 717785011898 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 717785011899 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 717785011900 RNase E interface [polypeptide binding]; other site 717785011901 trimer interface [polypeptide binding]; other site 717785011902 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 717785011903 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 717785011904 RNase E interface [polypeptide binding]; other site 717785011905 trimer interface [polypeptide binding]; other site 717785011906 active site 717785011907 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 717785011908 putative nucleic acid binding region [nucleotide binding]; other site 717785011909 G-X-X-G motif; other site 717785011910 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 717785011911 RNA binding site [nucleotide binding]; other site 717785011912 domain interface; other site 717785011913 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 717785011914 16S/18S rRNA binding site [nucleotide binding]; other site 717785011915 S13e-L30e interaction site [polypeptide binding]; other site 717785011916 25S rRNA binding site [nucleotide binding]; other site 717785011917 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 717785011918 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 717785011919 RNA binding site [nucleotide binding]; other site 717785011920 active site 717785011921 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 717785011922 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 717785011923 translation initiation factor IF-2; Validated; Region: infB; PRK05306 717785011924 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 717785011925 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 717785011926 G1 box; other site 717785011927 putative GEF interaction site [polypeptide binding]; other site 717785011928 GTP/Mg2+ binding site [chemical binding]; other site 717785011929 Switch I region; other site 717785011930 G2 box; other site 717785011931 G3 box; other site 717785011932 Switch II region; other site 717785011933 G4 box; other site 717785011934 G5 box; other site 717785011935 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 717785011936 Translation-initiation factor 2; Region: IF-2; pfam11987 717785011937 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 717785011938 hypothetical protein; Provisional; Region: PRK09190 717785011939 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 717785011940 putative RNA binding cleft [nucleotide binding]; other site 717785011941 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 717785011942 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 717785011943 NusA N-terminal domain; Region: NusA_N; pfam08529 717785011944 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 717785011945 RNA binding site [nucleotide binding]; other site 717785011946 homodimer interface [polypeptide binding]; other site 717785011947 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 717785011948 G-X-X-G motif; other site 717785011949 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 717785011950 G-X-X-G motif; other site 717785011951 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 717785011952 ribosome maturation protein RimP; Reviewed; Region: PRK00092 717785011953 Sm and related proteins; Region: Sm_like; cl00259 717785011954 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 717785011955 putative oligomer interface [polypeptide binding]; other site 717785011956 putative RNA binding site [nucleotide binding]; other site 717785011957 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 717785011958 S-adenosylmethionine synthetase; Validated; Region: PRK05250 717785011959 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 717785011960 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 717785011961 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 717785011962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785011963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785011964 sequence-specific DNA binding site [nucleotide binding]; other site 717785011965 salt bridge; other site 717785011966 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 717785011967 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 717785011968 putative active site [active] 717785011969 catalytic triad [active] 717785011970 putative dimer interface [polypeptide binding]; other site 717785011971 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 717785011972 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785011973 Transporter associated domain; Region: CorC_HlyC; smart01091 717785011974 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 717785011975 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 717785011976 PhoH-like protein; Region: PhoH; pfam02562 717785011977 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 717785011978 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785011979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 717785011980 FeS/SAM binding site; other site 717785011981 TRAM domain; Region: TRAM; pfam01938 717785011982 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 717785011983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785011984 putative acyl-acceptor binding pocket; other site 717785011985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785011986 metal binding site 2 [ion binding]; metal-binding site 717785011987 putative DNA binding helix; other site 717785011988 metal binding site 1 [ion binding]; metal-binding site 717785011989 dimer interface [polypeptide binding]; other site 717785011990 structural Zn2+ binding site [ion binding]; other site 717785011991 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 717785011992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785011993 Coenzyme A binding pocket [chemical binding]; other site 717785011994 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 717785011995 Glycoprotease family; Region: Peptidase_M22; pfam00814 717785011996 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 717785011997 putative FMN binding site [chemical binding]; other site 717785011998 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 717785011999 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 717785012000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785012001 Ligand Binding Site [chemical binding]; other site 717785012002 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 717785012003 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 717785012004 active site 717785012005 HIGH motif; other site 717785012006 dimer interface [polypeptide binding]; other site 717785012007 KMSKS motif; other site 717785012008 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 717785012009 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 717785012010 PII uridylyl-transferase; Provisional; Region: PRK05092 717785012011 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785012012 metal binding triad; other site 717785012013 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785012014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 717785012015 Zn2+ binding site [ion binding]; other site 717785012016 Mg2+ binding site [ion binding]; other site 717785012017 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 717785012018 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 717785012019 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 717785012020 MutS domain I; Region: MutS_I; pfam01624 717785012021 MutS domain II; Region: MutS_II; pfam05188 717785012022 MutS domain III; Region: MutS_III; pfam05192 717785012023 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 717785012024 Walker A/P-loop; other site 717785012025 ATP binding site [chemical binding]; other site 717785012026 Q-loop/lid; other site 717785012027 ABC transporter signature motif; other site 717785012028 Walker B; other site 717785012029 D-loop; other site 717785012030 H-loop/switch region; other site 717785012031 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 717785012032 Malic enzyme, N-terminal domain; Region: malic; pfam00390 717785012033 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 717785012034 putative NAD(P) binding site [chemical binding]; other site 717785012035 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 717785012036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 717785012037 PAS domain; Region: PAS; smart00091 717785012038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785012039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785012040 dimer interface [polypeptide binding]; other site 717785012041 phosphorylation site [posttranslational modification] 717785012042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785012043 ATP binding site [chemical binding]; other site 717785012044 Mg2+ binding site [ion binding]; other site 717785012045 G-X-G motif; other site 717785012046 Response regulator receiver domain; Region: Response_reg; pfam00072 717785012047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785012048 active site 717785012049 phosphorylation site [posttranslational modification] 717785012050 intermolecular recognition site; other site 717785012051 dimerization interface [polypeptide binding]; other site 717785012052 Uncharacterized conserved protein [Function unknown]; Region: COG2835 717785012053 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 717785012054 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 717785012055 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 717785012056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 717785012057 TPR motif; other site 717785012058 binding surface 717785012059 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 717785012060 putative deacylase active site [active] 717785012061 LemA family; Region: LemA; pfam04011 717785012062 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 717785012063 Repair protein; Region: Repair_PSII; pfam04536 717785012064 Predicted membrane protein [Function unknown]; Region: COG3762 717785012065 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 717785012066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785012067 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 717785012068 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 717785012069 purine monophosphate binding site [chemical binding]; other site 717785012070 dimer interface [polypeptide binding]; other site 717785012071 putative catalytic residues [active] 717785012072 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 717785012073 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 717785012074 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 717785012075 NusB family; Region: NusB; pfam01029 717785012076 putative RNA binding site [nucleotide binding]; other site 717785012077 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 717785012078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785012079 S-adenosylmethionine binding site [chemical binding]; other site 717785012080 Peptidase family M48; Region: Peptidase_M48; cl12018 717785012081 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 717785012082 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 717785012083 acetyl-CoA synthetase; Provisional; Region: PRK00174 717785012084 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 717785012085 active site 717785012086 CoA binding site [chemical binding]; other site 717785012087 acyl-activating enzyme (AAE) consensus motif; other site 717785012088 AMP binding site [chemical binding]; other site 717785012089 acetate binding site [chemical binding]; other site 717785012090 Predicted methyltransferase [General function prediction only]; Region: COG3897 717785012091 EVE domain; Region: EVE; cl00728 717785012092 GtrA-like protein; Region: GtrA; pfam04138 717785012093 hypothetical protein; Provisional; Region: PRK07208 717785012094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 717785012095 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 717785012096 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 717785012097 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 717785012098 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 717785012099 UGMP family protein; Validated; Region: PRK09604 717785012100 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 717785012101 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 717785012102 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 717785012103 domain interfaces; other site 717785012104 active site 717785012105 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 717785012106 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 717785012107 active site 717785012108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 717785012109 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 717785012110 HemY protein N-terminus; Region: HemY_N; pfam07219 717785012111 PilZ domain; Region: PilZ; pfam07238 717785012112 YARHG domain; Region: YARHG; pfam13308 717785012113 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785012114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 717785012115 HlyD family secretion protein; Region: HlyD_3; pfam13437 717785012116 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785012117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785012118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785012119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785012120 dimerization interface [polypeptide binding]; other site 717785012121 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785012122 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 717785012123 ligand binding site [chemical binding]; other site 717785012124 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 717785012125 hypothetical protein; Provisional; Region: PRK05409 717785012126 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 717785012127 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 717785012128 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 717785012129 catalytic residues [active] 717785012130 Predicted membrane protein [Function unknown]; Region: COG2259 717785012131 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785012132 classical (c) SDRs; Region: SDR_c; cd05233 717785012133 NAD(P) binding site [chemical binding]; other site 717785012134 active site 717785012135 Esterase/lipase [General function prediction only]; Region: COG1647 717785012136 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 717785012137 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785012138 dimer interface [polypeptide binding]; other site 717785012139 active site 717785012140 CoA binding pocket [chemical binding]; other site 717785012141 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 717785012142 Response regulator receiver domain; Region: Response_reg; pfam00072 717785012143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785012144 active site 717785012145 phosphorylation site [posttranslational modification] 717785012146 intermolecular recognition site; other site 717785012147 dimerization interface [polypeptide binding]; other site 717785012148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785012149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785012150 active site 717785012151 phosphorylation site [posttranslational modification] 717785012152 intermolecular recognition site; other site 717785012153 dimerization interface [polypeptide binding]; other site 717785012154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 717785012155 DNA binding residues [nucleotide binding] 717785012156 dimerization interface [polypeptide binding]; other site 717785012157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785012158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 717785012159 dimer interface [polypeptide binding]; other site 717785012160 phosphorylation site [posttranslational modification] 717785012161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785012162 ATP binding site [chemical binding]; other site 717785012163 Mg2+ binding site [ion binding]; other site 717785012164 G-X-G motif; other site 717785012165 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785012166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 717785012167 active site 717785012168 phosphorylation site [posttranslational modification] 717785012169 intermolecular recognition site; other site 717785012170 dimerization interface [polypeptide binding]; other site 717785012171 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 717785012172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 717785012173 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 717785012174 dimerization interface [polypeptide binding]; other site 717785012175 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 717785012176 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 717785012177 catalytic residue [active] 717785012178 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 717785012179 catalytic residues [active] 717785012180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785012181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785012182 peroxiredoxin; Region: AhpC; TIGR03137 717785012183 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 717785012184 dimer interface [polypeptide binding]; other site 717785012185 decamer (pentamer of dimers) interface [polypeptide binding]; other site 717785012186 catalytic triad [active] 717785012187 peroxidatic and resolving cysteines [active] 717785012188 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 717785012189 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 717785012190 Moco binding site; other site 717785012191 metal coordination site [ion binding]; other site 717785012192 Cytochrome c; Region: Cytochrom_C; cl11414 717785012193 allantoate amidohydrolase; Reviewed; Region: PRK09290 717785012194 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 717785012195 active site 717785012196 metal binding site [ion binding]; metal-binding site 717785012197 dimer interface [polypeptide binding]; other site 717785012198 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 717785012199 nucleoside/Zn binding site; other site 717785012200 dimer interface [polypeptide binding]; other site 717785012201 catalytic motif [active] 717785012202 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 717785012203 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 717785012204 AsnC family; Region: AsnC_trans_reg; pfam01037 717785012205 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785012206 Cytochrome c; Region: Cytochrom_C; cl11414 717785012207 Cytochrome c; Region: Cytochrom_C; cl11414 717785012208 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785012209 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 717785012210 Trp docking motif [polypeptide binding]; other site 717785012211 cytochrome domain interface [polypeptide binding]; other site 717785012212 active site 717785012213 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 717785012214 Secretory lipase; Region: LIP; pfam03583 717785012215 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 717785012216 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785012217 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 717785012218 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 717785012219 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 717785012220 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 717785012221 CGNR zinc finger; Region: zf-CGNR; pfam11706 717785012222 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785012223 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785012224 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 717785012225 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 717785012226 putative NAD(P) binding site [chemical binding]; other site 717785012227 mercuric reductase; Validated; Region: PRK06370 717785012228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785012229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785012230 RNA polymerase sigma factor; Provisional; Region: PRK12512 717785012231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785012232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 717785012233 DNA binding residues [nucleotide binding] 717785012234 CGNR zinc finger; Region: zf-CGNR; pfam11706 717785012235 organic solvent tolerance protein; Provisional; Region: PRK04423 717785012236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785012237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785012238 ATP binding site [chemical binding]; other site 717785012239 Mg2+ binding site [ion binding]; other site 717785012240 G-X-G motif; other site 717785012241 mercuric reductase; Validated; Region: PRK06370 717785012242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 717785012243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 717785012244 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785012245 Ribonuclease P; Region: Ribonuclease_P; cl00457 717785012246 membrane protein insertase; Provisional; Region: PRK01318 717785012247 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 717785012248 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 717785012249 G1 box; other site 717785012250 GTP/Mg2+ binding site [chemical binding]; other site 717785012251 Switch I region; other site 717785012252 G2 box; other site 717785012253 G3 box; other site 717785012254 Switch II region; other site 717785012255 G4 box; other site 717785012256 G5 box; other site 717785012257 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 717785012258 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 717785012259 feedback inhibition sensing region; other site 717785012260 homohexameric interface [polypeptide binding]; other site 717785012261 nucleotide binding site [chemical binding]; other site 717785012262 N-acetyl-L-glutamate binding site [chemical binding]; other site 717785012263 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 717785012264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 717785012265 motif II; other site 717785012266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785012267 classical (c) SDRs; Region: SDR_c; cd05233 717785012268 NAD(P) binding site [chemical binding]; other site 717785012269 active site 717785012270 Double zinc ribbon; Region: DZR; pfam12773 717785012271 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 717785012272 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 717785012273 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 717785012274 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 717785012275 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 717785012276 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 717785012277 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785012278 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 717785012279 Ligand binding site [chemical binding]; other site 717785012280 Electron transfer flavoprotein domain; Region: ETF; pfam01012 717785012281 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 717785012282 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 717785012283 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 717785012284 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 717785012285 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785012286 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 717785012287 C-terminal peptidase (prc); Region: prc; TIGR00225 717785012288 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 717785012289 protein binding site [polypeptide binding]; other site 717785012290 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 717785012291 Catalytic dyad [active] 717785012292 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 717785012293 putative active site [active] 717785012294 Ap4A binding site [chemical binding]; other site 717785012295 nudix motif; other site 717785012296 putative metal binding site [ion binding]; other site 717785012297 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 717785012298 putative active site [active] 717785012299 Ap4A binding site [chemical binding]; other site 717785012300 nudix motif; other site 717785012301 putative metal binding site [ion binding]; other site 717785012302 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 717785012303 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 717785012304 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 717785012305 metabolite-proton symporter; Region: 2A0106; TIGR00883 717785012306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785012307 putative substrate translocation pore; other site 717785012308 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785012309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 717785012310 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 717785012311 acyl-activating enzyme (AAE) consensus motif; other site 717785012312 acyl-activating enzyme (AAE) consensus motif; other site 717785012313 putative AMP binding site [chemical binding]; other site 717785012314 putative active site [active] 717785012315 putative CoA binding site [chemical binding]; other site 717785012316 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 717785012317 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 717785012318 RNA polymerase Rpb8; Region: RNA_pol_Rpb8; cl02716 717785012319 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 717785012320 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 717785012321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785012322 putative substrate translocation pore; other site 717785012323 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 717785012324 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 717785012325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785012326 S-adenosylmethionine binding site [chemical binding]; other site 717785012327 aspartate kinase; Reviewed; Region: PRK06635 717785012328 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 717785012329 putative nucleotide binding site [chemical binding]; other site 717785012330 putative catalytic residues [active] 717785012331 putative Mg ion binding site [ion binding]; other site 717785012332 putative aspartate binding site [chemical binding]; other site 717785012333 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 717785012334 putative allosteric regulatory site; other site 717785012335 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 717785012336 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 717785012337 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 717785012338 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 717785012339 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 717785012340 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 717785012341 Helix-turn-helix domain; Region: HTH_25; pfam13413 717785012342 peptide chain release factor 1; Validated; Region: prfA; PRK00591 717785012343 This domain is found in peptide chain release factors; Region: PCRF; smart00937 717785012344 RF-1 domain; Region: RF-1; pfam00472 717785012345 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 717785012346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785012347 S-adenosylmethionine binding site [chemical binding]; other site 717785012348 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 717785012349 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 717785012350 MOSC domain; Region: MOSC; pfam03473 717785012351 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 717785012352 Clp amino terminal domain; Region: Clp_N; pfam02861 717785012353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785012354 Walker A motif; other site 717785012355 ATP binding site [chemical binding]; other site 717785012356 Walker B motif; other site 717785012357 arginine finger; other site 717785012358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 717785012359 Walker A motif; other site 717785012360 ATP binding site [chemical binding]; other site 717785012361 Walker B motif; other site 717785012362 arginine finger; other site 717785012363 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785012364 short chain dehydrogenase; Validated; Region: PRK06182 717785012365 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785012366 NADP binding site [chemical binding]; other site 717785012367 active site 717785012368 steroid binding site; other site 717785012369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785012370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785012371 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 717785012372 SnoaL-like domain; Region: SnoaL_2; pfam12680 717785012373 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 717785012374 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785012375 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 717785012376 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785012377 ligand binding site [chemical binding]; other site 717785012378 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 717785012379 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 717785012380 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 717785012381 Cytochrome c; Region: Cytochrom_C; cl11414 717785012382 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785012383 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 717785012384 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717785012385 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785012386 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 717785012387 Iron permease FTR1 family; Region: FTR1; cl00475 717785012388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 717785012389 SnoaL-like domain; Region: SnoaL_2; pfam12680 717785012390 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 717785012391 ABC1 family; Region: ABC1; cl17513 717785012392 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 717785012393 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 717785012394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 717785012395 S-adenosylmethionine binding site [chemical binding]; other site 717785012396 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 717785012397 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 717785012398 DNA binding site [nucleotide binding] 717785012399 catalytic residue [active] 717785012400 H2TH interface [polypeptide binding]; other site 717785012401 putative catalytic residues [active] 717785012402 turnover-facilitating residue; other site 717785012403 intercalation triad [nucleotide binding]; other site 717785012404 8OG recognition residue [nucleotide binding]; other site 717785012405 putative reading head residues; other site 717785012406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 717785012407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 717785012408 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 717785012409 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 717785012410 active site residue [active]