-- dump date   	20140619_115453
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
582899000001	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
582899000002	active site residue [active]
582899000003	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
582899000004	DnaA N-terminal domain; Region: DnaA_N; pfam11638
582899000005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899000006	Walker A motif; other site
582899000007	ATP binding site [chemical binding]; other site
582899000008	Walker B motif; other site
582899000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
582899000010	DnaA box-binding interface [nucleotide binding]; other site
582899000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
582899000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
582899000013	putative DNA binding surface [nucleotide binding]; other site
582899000014	dimer interface [polypeptide binding]; other site
582899000015	beta-clamp/clamp loader binding surface; other site
582899000016	beta-clamp/translesion DNA polymerase binding surface; other site
582899000017	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
582899000018	putative active site [active]
582899000019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899000020	Walker A/P-loop; other site
582899000021	ATP binding site [chemical binding]; other site
582899000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899000023	recombination protein F; Reviewed; Region: recF; PRK00064
582899000024	Q-loop/lid; other site
582899000025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899000026	ABC transporter signature motif; other site
582899000027	Walker B; other site
582899000028	D-loop; other site
582899000029	H-loop/switch region; other site
582899000030	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
582899000031	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
582899000032	Mg2+ binding site [ion binding]; other site
582899000033	G-X-G motif; other site
582899000034	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
582899000035	anchoring element; other site
582899000036	dimer interface [polypeptide binding]; other site
582899000037	ATP binding site [chemical binding]; other site
582899000038	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
582899000039	active site
582899000040	putative metal-binding site [ion binding]; other site
582899000041	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
582899000042	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
582899000043	TrkA-N domain; Region: TrkA_N; pfam02254
582899000044	Transglycosylase; Region: Transgly; pfam00912
582899000045	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
582899000046	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582899000047	Protein of unknown function DUF45; Region: DUF45; pfam01863
582899000048	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
582899000049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899000050	Cu(I) binding site [ion binding]; other site
582899000051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899000052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899000053	ATP binding site [chemical binding]; other site
582899000054	Mg2+ binding site [ion binding]; other site
582899000055	G-X-G motif; other site
582899000056	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
582899000057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899000058	active site
582899000059	phosphorylation site [posttranslational modification]
582899000060	intermolecular recognition site; other site
582899000061	dimerization interface [polypeptide binding]; other site
582899000062	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
582899000063	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
582899000064	AAA domain; Region: AAA_32; pfam13654
582899000065	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
582899000066	GcrA cell cycle regulator; Region: GcrA; cl11564
582899000067	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
582899000068	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582899000069	inhibitor-cofactor binding pocket; inhibition site
582899000070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899000071	catalytic residue [active]
582899000072	ornithine carbamoyltransferase; Provisional; Region: PRK00779
582899000073	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
582899000074	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
582899000075	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
582899000076	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
582899000077	dimerization interface [polypeptide binding]; other site
582899000078	domain crossover interface; other site
582899000079	redox-dependent activation switch; other site
582899000080	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
582899000081	Ca2+ binding site [ion binding]; other site
582899000082	acetylornithine deacetylase; Provisional; Region: PRK07522
582899000083	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
582899000084	metal binding site [ion binding]; metal-binding site
582899000085	putative dimer interface [polypeptide binding]; other site
582899000086	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
582899000087	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
582899000088	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582899000089	homodimer interface [polypeptide binding]; other site
582899000090	substrate-cofactor binding pocket; other site
582899000091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899000092	catalytic residue [active]
582899000093	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
582899000094	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
582899000095	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
582899000096	trimer interface [polypeptide binding]; other site
582899000097	active site
582899000098	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
582899000099	trimer interface [polypeptide binding]; other site
582899000100	active site
582899000101	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
582899000102	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
582899000103	IHF - DNA interface [nucleotide binding]; other site
582899000104	IHF dimer interface [polypeptide binding]; other site
582899000105	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
582899000106	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
582899000107	metal binding site [ion binding]; metal-binding site
582899000108	dimer interface [polypeptide binding]; other site
582899000109	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
582899000110	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
582899000111	trimer interface [polypeptide binding]; other site
582899000112	active site
582899000113	substrate binding site [chemical binding]; other site
582899000114	CoA binding site [chemical binding]; other site
582899000115	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
582899000116	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
582899000117	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899000118	catalytic residues [active]
582899000119	argininosuccinate lyase; Provisional; Region: PRK00855
582899000120	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
582899000121	active sites [active]
582899000122	tetramer interface [polypeptide binding]; other site
582899000123	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
582899000124	diaminopimelate decarboxylase; Region: lysA; TIGR01048
582899000125	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
582899000126	active site
582899000127	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582899000128	substrate binding site [chemical binding]; other site
582899000129	catalytic residues [active]
582899000130	dimer interface [polypeptide binding]; other site
582899000131	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
582899000132	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
582899000133	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
582899000134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899000135	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582899000136	dimerization interface [polypeptide binding]; other site
582899000137	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
582899000138	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
582899000139	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
582899000140	Transglycosylase; Region: Transgly; pfam00912
582899000141	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
582899000142	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
582899000143	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
582899000144	MG2 domain; Region: A2M_N; pfam01835
582899000145	Alpha-2-macroglobulin family; Region: A2M; pfam00207
582899000146	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
582899000147	surface patch; other site
582899000148	thioester region; other site
582899000149	specificity defining residues; other site
582899000150	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
582899000151	Transglycosylase; Region: Transgly; cl17702
582899000152	Domain of unknown function DUF87; Region: DUF87; pfam01935
582899000153	AAA-like domain; Region: AAA_10; pfam12846
582899000154	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
582899000155	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
582899000156	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
582899000157	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
582899000158	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
582899000159	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
582899000160	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899000161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899000162	putative substrate translocation pore; other site
582899000163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899000164	putative substrate translocation pore; other site
582899000165	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582899000166	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582899000167	active site
582899000168	catalytic tetrad [active]
582899000169	hypothetical protein; Provisional; Region: PRK12472
582899000170	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899000171	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
582899000172	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
582899000173	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
582899000174	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
582899000175	nudix motif; other site
582899000176	salicylate hydroxylase; Provisional; Region: PRK08163
582899000177	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899000178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
582899000179	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899000180	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899000181	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
582899000182	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
582899000183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899000184	WHG domain; Region: WHG; pfam13305
582899000185	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
582899000186	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
582899000187	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
582899000188	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
582899000189	putative metal binding site [ion binding]; other site
582899000190	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582899000191	HSP70 interaction site [polypeptide binding]; other site
582899000192	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
582899000193	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
582899000194	amidase catalytic site [active]
582899000195	Zn binding residues [ion binding]; other site
582899000196	substrate binding site [chemical binding]; other site
582899000197	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899000198	putative metal dependent hydrolase; Provisional; Region: PRK11598
582899000199	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
582899000200	Sulfatase; Region: Sulfatase; pfam00884
582899000201	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899000202	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
582899000203	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899000204	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899000205	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
582899000206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899000207	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899000208	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
582899000209	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
582899000210	4Fe-4S binding domain; Region: Fer4; cl02805
582899000211	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
582899000212	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899000213	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
582899000214	putative ligand binding site [chemical binding]; other site
582899000215	Transcriptional regulators [Transcription]; Region: FadR; COG2186
582899000216	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582899000217	DNA-binding site [nucleotide binding]; DNA binding site
582899000218	FCD domain; Region: FCD; pfam07729
582899000219	Amino acid permease; Region: AA_permease_2; pfam13520
582899000220	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
582899000221	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
582899000222	FMN-binding pocket [chemical binding]; other site
582899000223	flavin binding motif; other site
582899000224	phosphate binding motif [ion binding]; other site
582899000225	beta-alpha-beta structure motif; other site
582899000226	NAD binding pocket [chemical binding]; other site
582899000227	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582899000228	catalytic loop [active]
582899000229	iron binding site [ion binding]; other site
582899000230	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
582899000231	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
582899000232	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
582899000233	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582899000234	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
582899000235	apolar tunnel; other site
582899000236	heme binding site [chemical binding]; other site
582899000237	dimerization interface [polypeptide binding]; other site
582899000238	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
582899000239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899000240	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582899000241	Peptidase family M23; Region: Peptidase_M23; pfam01551
582899000242	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
582899000243	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
582899000244	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
582899000245	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
582899000246	acyl-activating enzyme (AAE) consensus motif; other site
582899000247	AMP binding site [chemical binding]; other site
582899000248	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
582899000249	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
582899000250	putative trimer interface [polypeptide binding]; other site
582899000251	putative CoA binding site [chemical binding]; other site
582899000252	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
582899000253	putative trimer interface [polypeptide binding]; other site
582899000254	putative CoA binding site [chemical binding]; other site
582899000255	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
582899000256	putative trimer interface [polypeptide binding]; other site
582899000257	putative CoA binding site [chemical binding]; other site
582899000258	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899000259	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
582899000260	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
582899000261	NAD binding site [chemical binding]; other site
582899000262	homodimer interface [polypeptide binding]; other site
582899000263	active site
582899000264	substrate binding site [chemical binding]; other site
582899000265	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
582899000266	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582899000267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
582899000268	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
582899000269	Predicted kinase [General function prediction only]; Region: COG0645
582899000270	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
582899000271	active site
582899000272	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
582899000273	30S subunit binding site; other site
582899000274	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
582899000275	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
582899000276	catalytic Zn binding site [ion binding]; other site
582899000277	structural Zn binding site [ion binding]; other site
582899000278	NAD(P) binding site [chemical binding]; other site
582899000279	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
582899000280	chaperone protein DnaJ; Provisional; Region: PRK14289
582899000281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582899000282	PAS domain; Region: PAS_9; pfam13426
582899000283	putative active site [active]
582899000284	heme pocket [chemical binding]; other site
582899000285	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
582899000286	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
582899000287	NADP binding site [chemical binding]; other site
582899000288	active site
582899000289	putative substrate binding site [chemical binding]; other site
582899000290	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
582899000291	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
582899000292	NADP-binding site; other site
582899000293	homotetramer interface [polypeptide binding]; other site
582899000294	substrate binding site [chemical binding]; other site
582899000295	homodimer interface [polypeptide binding]; other site
582899000296	active site
582899000297	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582899000298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582899000299	dimer interface [polypeptide binding]; other site
582899000300	putative CheW interface [polypeptide binding]; other site
582899000301	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
582899000302	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899000303	substrate binding pocket [chemical binding]; other site
582899000304	membrane-bound complex binding site; other site
582899000305	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
582899000306	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
582899000307	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
582899000308	homodimer interface [polypeptide binding]; other site
582899000309	NADP binding site [chemical binding]; other site
582899000310	substrate binding site [chemical binding]; other site
582899000311	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
582899000312	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
582899000313	Potassium binding sites [ion binding]; other site
582899000314	Cesium cation binding sites [ion binding]; other site
582899000315	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
582899000316	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
582899000317	NAD(P) binding site [chemical binding]; other site
582899000318	homodimer interface [polypeptide binding]; other site
582899000319	substrate binding site [chemical binding]; other site
582899000320	active site
582899000321	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
582899000322	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
582899000323	active site
582899000324	catalytic residues [active]
582899000325	DNA binding site [nucleotide binding]
582899000326	Int/Topo IB signature motif; other site
582899000327	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
582899000328	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
582899000329	Helix-turn-helix domain; Region: HTH_17; pfam12728
582899000330	HNH endonuclease; Region: HNH_3; pfam13392
582899000331	AP2 domain; Region: AP2; pfam00847
582899000332	DNA binding site [nucleotide binding]
582899000333	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
582899000334	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
582899000335	active site
582899000336	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
582899000337	ERF superfamily; Region: ERF; pfam04404
582899000338	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899000339	sequence-specific DNA binding site [nucleotide binding]; other site
582899000340	salt bridge; other site
582899000341	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886
582899000342	Transcription antiterminator [Transcription]; Region: NusG; COG0250
582899000343	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
582899000344	Predicted transcriptional regulator [Transcription]; Region: COG2944
582899000345	HNH endonuclease; Region: HNH_3; pfam13392
582899000346	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
582899000347	Terminase small subunit; Region: Terminase_2; cl01513
582899000348	Phage terminase large subunit; Region: Terminase_3; cl12054
582899000349	Terminase-like family; Region: Terminase_6; pfam03237
582899000350	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
582899000351	HNH endonuclease; Region: HNH_3; pfam13392
582899000352	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
582899000353	TIGR02594 family protein; Region: TIGR02594
582899000354	HNH endonuclease; Region: HNH_3; pfam13392
582899000355	AP2 domain; Region: AP2; pfam00847
582899000356	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
582899000357	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
582899000358	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
582899000359	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899000360	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
582899000361	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
582899000362	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
582899000363	NAD(P) binding site [chemical binding]; other site
582899000364	homodimer interface [polypeptide binding]; other site
582899000365	substrate binding site [chemical binding]; other site
582899000366	active site
582899000367	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
582899000368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899000369	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
582899000370	NAD(P) binding site [chemical binding]; other site
582899000371	active site
582899000372	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
582899000373	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
582899000374	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
582899000375	active site
582899000376	homodimer interface [polypeptide binding]; other site
582899000377	putative glycosyl transferase; Provisional; Region: PRK10307
582899000378	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
582899000379	Bacterial sugar transferase; Region: Bac_transf; pfam02397
582899000380	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
582899000381	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
582899000382	putative trimer interface [polypeptide binding]; other site
582899000383	putative CoA binding site [chemical binding]; other site
582899000384	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
582899000385	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
582899000386	inhibitor-cofactor binding pocket; inhibition site
582899000387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899000388	catalytic residue [active]
582899000389	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
582899000390	putative metal binding site; other site
582899000391	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
582899000392	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
582899000393	FMN binding site [chemical binding]; other site
582899000394	active site
582899000395	homodimer interface [polypeptide binding]; other site
582899000396	putative catalytic residue [active]
582899000397	4Fe-4S cluster binding site [ion binding]; other site
582899000398	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582899000399	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
582899000400	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
582899000401	4Fe-4S binding domain; Region: Fer4; cl02805
582899000402	Cysteine-rich domain; Region: CCG; pfam02754
582899000403	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582899000404	Ligand binding site [chemical binding]; other site
582899000405	Electron transfer flavoprotein domain; Region: ETF; pfam01012
582899000406	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
582899000407	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582899000408	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582899000409	AIPR protein; Region: AIPR; pfam10592
582899000410	hypothetical protein; Provisional; Region: PRK11469
582899000411	Domain of unknown function DUF; Region: DUF204; pfam02659
582899000412	Domain of unknown function DUF; Region: DUF204; pfam02659
582899000413	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
582899000414	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
582899000415	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
582899000416	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
582899000417	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582899000418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582899000419	GTPase CgtA; Reviewed; Region: obgE; PRK12299
582899000420	GTP1/OBG; Region: GTP1_OBG; pfam01018
582899000421	Obg GTPase; Region: Obg; cd01898
582899000422	G1 box; other site
582899000423	GTP/Mg2+ binding site [chemical binding]; other site
582899000424	Switch I region; other site
582899000425	G2 box; other site
582899000426	G3 box; other site
582899000427	Switch II region; other site
582899000428	G4 box; other site
582899000429	G5 box; other site
582899000430	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
582899000431	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582899000432	gamma-glutamyl kinase; Provisional; Region: PRK05429
582899000433	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
582899000434	nucleotide binding site [chemical binding]; other site
582899000435	homotetrameric interface [polypeptide binding]; other site
582899000436	putative phosphate binding site [ion binding]; other site
582899000437	putative allosteric binding site; other site
582899000438	PUA domain; Region: PUA; pfam01472
582899000439	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
582899000440	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
582899000441	putative catalytic cysteine [active]
582899000442	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
582899000443	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
582899000444	active site
582899000445	(T/H)XGH motif; other site
582899000446	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
582899000447	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
582899000448	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
582899000449	putative active site [active]
582899000450	short chain dehydrogenase; Provisional; Region: PRK05993
582899000451	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
582899000452	NADP binding site [chemical binding]; other site
582899000453	active site
582899000454	steroid binding site; other site
582899000455	META domain; Region: META; pfam03724
582899000456	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582899000457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582899000458	active site
582899000459	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
582899000460	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
582899000461	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
582899000462	putative NAD(P) binding site [chemical binding]; other site
582899000463	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
582899000464	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
582899000465	B12 binding site [chemical binding]; other site
582899000466	cobalt ligand [ion binding]; other site
582899000467	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
582899000468	O-Antigen ligase; Region: Wzy_C; pfam04932
582899000469	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582899000470	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582899000471	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
582899000472	PBP superfamily domain; Region: PBP_like; pfam12727
582899000473	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
582899000474	catalytic site [active]
582899000475	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899000476	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809
582899000477	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582899000478	catalytic site [active]
582899000479	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
582899000480	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
582899000481	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899000482	N-terminal plug; other site
582899000483	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582899000484	ligand-binding site [chemical binding]; other site
582899000485	CrcB-like protein; Region: CRCB; cl09114
582899000486	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
582899000487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
582899000488	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
582899000489	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
582899000490	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
582899000491	Domain of unknown function (DUF427); Region: DUF427; pfam04248
582899000492	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899000493	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
582899000494	cell division protein MraZ; Reviewed; Region: PRK00326
582899000495	MraZ protein; Region: MraZ; pfam02381
582899000496	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
582899000497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899000498	S-adenosylmethionine binding site [chemical binding]; other site
582899000499	Cell division protein FtsL; Region: FtsL; cl11433
582899000500	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
582899000501	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
582899000502	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582899000503	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
582899000504	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582899000505	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582899000506	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582899000507	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
582899000508	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582899000509	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582899000510	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582899000511	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
582899000512	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
582899000513	Mg++ binding site [ion binding]; other site
582899000514	putative catalytic motif [active]
582899000515	putative substrate binding site [chemical binding]; other site
582899000516	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
582899000517	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582899000518	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582899000519	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
582899000520	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
582899000521	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
582899000522	active site
582899000523	homodimer interface [polypeptide binding]; other site
582899000524	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
582899000525	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582899000526	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582899000527	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582899000528	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
582899000529	FAD binding domain; Region: FAD_binding_4; pfam01565
582899000530	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
582899000531	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
582899000532	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
582899000533	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582899000534	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
582899000535	Cell division protein FtsQ; Region: FtsQ; pfam03799
582899000536	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
582899000537	Cell division protein FtsA; Region: FtsA; smart00842
582899000538	Cell division protein FtsA; Region: FtsA; pfam14450
582899000539	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
582899000540	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
582899000541	nucleotide binding site [chemical binding]; other site
582899000542	SulA interaction site; other site
582899000543	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
582899000544	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
582899000545	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
582899000546	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
582899000547	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
582899000548	nucleotide binding pocket [chemical binding]; other site
582899000549	K-X-D-G motif; other site
582899000550	catalytic site [active]
582899000551	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
582899000552	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
582899000553	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
582899000554	Dimer interface [polypeptide binding]; other site
582899000555	BRCT sequence motif; other site
582899000556	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
582899000557	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
582899000558	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
582899000559	active site
582899000560	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
582899000561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899000562	S-adenosylmethionine binding site [chemical binding]; other site
582899000563	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
582899000564	DnaJ domain; Region: DnaJ; pfam00226
582899000565	HSP70 interaction site [polypeptide binding]; other site
582899000566	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
582899000567	Part of AAA domain; Region: AAA_19; pfam13245
582899000568	Family description; Region: UvrD_C_2; pfam13538
582899000569	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
582899000570	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
582899000571	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
582899000572	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
582899000573	fumarate hydratase; Reviewed; Region: fumC; PRK00485
582899000574	Class II fumarases; Region: Fumarase_classII; cd01362
582899000575	active site
582899000576	tetramer interface [polypeptide binding]; other site
582899000577	Uncharacterized conserved protein [Function unknown]; Region: COG5361
582899000578	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
582899000579	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
582899000580	Methyltransferase domain; Region: Methyltransf_12; pfam08242
582899000581	Stringent starvation protein B; Region: SspB; pfam04386
582899000582	CAAX protease self-immunity; Region: Abi; pfam02517
582899000583	thymidylate synthase; Reviewed; Region: thyA; PRK01827
582899000584	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
582899000585	dimerization interface [polypeptide binding]; other site
582899000586	active site
582899000587	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
582899000588	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
582899000589	folate binding site [chemical binding]; other site
582899000590	NADP+ binding site [chemical binding]; other site
582899000591	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
582899000592	HflK protein; Region: hflK; TIGR01933
582899000593	FtsH protease regulator HflC; Provisional; Region: PRK11029
582899000594	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
582899000595	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582899000596	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582899000597	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899000598	protein binding site [polypeptide binding]; other site
582899000599	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899000600	protein binding site [polypeptide binding]; other site
582899000601	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
582899000602	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
582899000603	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
582899000604	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
582899000605	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
582899000606	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
582899000607	Substrate binding site; other site
582899000608	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
582899000609	Domain of unknown function DUF87; Region: DUF87; pfam01935
582899000610	AAA-like domain; Region: AAA_10; pfam12846
582899000611	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899000612	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899000613	dimer interface [polypeptide binding]; other site
582899000614	phosphorylation site [posttranslational modification]
582899000615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899000616	ATP binding site [chemical binding]; other site
582899000617	Mg2+ binding site [ion binding]; other site
582899000618	G-X-G motif; other site
582899000619	TonB C terminal; Region: TonB_2; pfam13103
582899000620	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
582899000621	TolR protein; Region: tolR; TIGR02801
582899000622	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582899000623	Chain length determinant protein; Region: Wzz; pfam02706
582899000624	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
582899000625	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
582899000626	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
582899000627	dimerization interface [polypeptide binding]; other site
582899000628	ligand binding site [chemical binding]; other site
582899000629	NADP binding site [chemical binding]; other site
582899000630	catalytic site [active]
582899000631	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582899000632	GIY-YIG motif/motif A; other site
582899000633	putative active site [active]
582899000634	putative metal binding site [ion binding]; other site
582899000635	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
582899000636	Amidase; Region: Amidase; pfam01425
582899000637	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
582899000638	homodimer interface [polypeptide binding]; other site
582899000639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899000640	catalytic residue [active]
582899000641	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
582899000642	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899000643	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
582899000644	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
582899000645	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
582899000646	metal binding site [ion binding]; metal-binding site
582899000647	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
582899000648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899000649	active site
582899000650	phosphorylation site [posttranslational modification]
582899000651	intermolecular recognition site; other site
582899000652	dimerization interface [polypeptide binding]; other site
582899000653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899000654	DNA binding site [nucleotide binding]
582899000655	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
582899000656	PhoU domain; Region: PhoU; pfam01895
582899000657	PhoU domain; Region: PhoU; pfam01895
582899000658	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
582899000659	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
582899000660	Walker A/P-loop; other site
582899000661	ATP binding site [chemical binding]; other site
582899000662	Q-loop/lid; other site
582899000663	ABC transporter signature motif; other site
582899000664	Walker B; other site
582899000665	D-loop; other site
582899000666	H-loop/switch region; other site
582899000667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899000668	dimer interface [polypeptide binding]; other site
582899000669	conserved gate region; other site
582899000670	putative PBP binding loops; other site
582899000671	ABC-ATPase subunit interface; other site
582899000672	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
582899000673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899000674	dimer interface [polypeptide binding]; other site
582899000675	conserved gate region; other site
582899000676	putative PBP binding loops; other site
582899000677	ABC-ATPase subunit interface; other site
582899000678	PBP superfamily domain; Region: PBP_like_2; cl17296
582899000679	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
582899000680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899000681	dimer interface [polypeptide binding]; other site
582899000682	phosphorylation site [posttranslational modification]
582899000683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899000684	ATP binding site [chemical binding]; other site
582899000685	Mg2+ binding site [ion binding]; other site
582899000686	G-X-G motif; other site
582899000687	Transcriptional regulator; Region: Rrf2; cl17282
582899000688	Rrf2 family protein; Region: rrf2_super; TIGR00738
582899000689	Imelysin; Region: Peptidase_M75; cl09159
582899000690	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
582899000691	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
582899000692	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
582899000693	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
582899000694	Imelysin; Region: Peptidase_M75; cl09159
582899000695	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
582899000696	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
582899000697	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582899000698	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899000699	FeS/SAM binding site; other site
582899000700	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
582899000701	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
582899000702	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
582899000703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899000704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899000705	WHG domain; Region: WHG; pfam13305
582899000706	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582899000707	TadE-like protein; Region: TadE; pfam07811
582899000708	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582899000709	TadE-like protein; Region: TadE; pfam07811
582899000710	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
582899000711	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
582899000712	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
582899000713	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
582899000714	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
582899000715	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
582899000716	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
582899000717	BON domain; Region: BON; pfam04972
582899000718	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
582899000719	Type IV pili component [Cell motility and secretion]; Region: COG5461
582899000720	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
582899000721	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
582899000722	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
582899000723	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
582899000724	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
582899000725	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
582899000726	ATP binding site [chemical binding]; other site
582899000727	Walker A motif; other site
582899000728	hexamer interface [polypeptide binding]; other site
582899000729	Walker B motif; other site
582899000730	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
582899000731	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582899000732	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
582899000733	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582899000734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899000735	binding surface
582899000736	TPR motif; other site
582899000737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899000738	TPR motif; other site
582899000739	binding surface
582899000740	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
582899000741	interface (dimer of trimers) [polypeptide binding]; other site
582899000742	Substrate-binding/catalytic site; other site
582899000743	Zn-binding sites [ion binding]; other site
582899000744	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
582899000745	NlpC/P60 family; Region: NLPC_P60; cl17555
582899000746	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
582899000747	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899000748	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
582899000749	putative S-transferase; Provisional; Region: PRK11752
582899000750	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
582899000751	C-terminal domain interface [polypeptide binding]; other site
582899000752	GSH binding site (G-site) [chemical binding]; other site
582899000753	dimer interface [polypeptide binding]; other site
582899000754	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
582899000755	dimer interface [polypeptide binding]; other site
582899000756	N-terminal domain interface [polypeptide binding]; other site
582899000757	active site
582899000758	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
582899000759	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
582899000760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899000761	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
582899000762	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
582899000763	DNA binding site [nucleotide binding]
582899000764	active site
582899000765	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
582899000766	Predicted transporter component [General function prediction only]; Region: COG2391
582899000767	N-acetyltransferase; Region: Acetyltransf_2; cl00949
582899000768	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
582899000769	active site residue [active]
582899000770	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582899000771	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899000772	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899000773	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899000774	Cytochrome c; Region: Cytochrom_C; cl11414
582899000775	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
582899000776	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
582899000777	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899000778	substrate binding pocket [chemical binding]; other site
582899000779	membrane-bound complex binding site; other site
582899000780	hinge residues; other site
582899000781	Predicted secreted protein [Function unknown]; Region: COG5501
582899000782	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
582899000783	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582899000784	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899000785	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899000786	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
582899000787	dimer interface [polypeptide binding]; other site
582899000788	Trp docking motif [polypeptide binding]; other site
582899000789	active site
582899000790	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
582899000791	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
582899000792	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
582899000793	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
582899000794	Fe-S cluster binding site [ion binding]; other site
582899000795	active site
582899000796	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
582899000797	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899000798	FeS/SAM binding site; other site
582899000799	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582899000800	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582899000801	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582899000802	Predicted membrane protein [Function unknown]; Region: COG2510
582899000803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899000804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899000805	active site
582899000806	phosphorylation site [posttranslational modification]
582899000807	intermolecular recognition site; other site
582899000808	dimerization interface [polypeptide binding]; other site
582899000809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899000810	DNA binding site [nucleotide binding]
582899000811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899000812	HAMP domain; Region: HAMP; pfam00672
582899000813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899000814	dimer interface [polypeptide binding]; other site
582899000815	phosphorylation site [posttranslational modification]
582899000816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899000817	ATP binding site [chemical binding]; other site
582899000818	Mg2+ binding site [ion binding]; other site
582899000819	G-X-G motif; other site
582899000820	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
582899000821	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582899000822	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582899000823	ATP binding site [chemical binding]; other site
582899000824	putative Mg++ binding site [ion binding]; other site
582899000825	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899000826	nucleotide binding region [chemical binding]; other site
582899000827	ATP-binding site [chemical binding]; other site
582899000828	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
582899000829	RNA binding site [nucleotide binding]; other site
582899000830	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
582899000831	Methyltransferase domain; Region: Methyltransf_26; pfam13659
582899000832	DNA polymerase I; Provisional; Region: PRK05755
582899000833	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
582899000834	active site
582899000835	metal binding site 1 [ion binding]; metal-binding site
582899000836	putative 5' ssDNA interaction site; other site
582899000837	metal binding site 3; metal-binding site
582899000838	metal binding site 2 [ion binding]; metal-binding site
582899000839	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
582899000840	putative DNA binding site [nucleotide binding]; other site
582899000841	putative metal binding site [ion binding]; other site
582899000842	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
582899000843	active site
582899000844	catalytic site [active]
582899000845	substrate binding site [chemical binding]; other site
582899000846	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
582899000847	active site
582899000848	DNA binding site [nucleotide binding]
582899000849	catalytic site [active]
582899000850	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
582899000851	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
582899000852	TLC ATP/ADP transporter; Region: TLC; cl03940
582899000853	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
582899000854	rRNA binding site [nucleotide binding]; other site
582899000855	predicted 30S ribosome binding site; other site
582899000856	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582899000857	DNA-binding site [nucleotide binding]; DNA binding site
582899000858	RNA-binding motif; other site
582899000859	Peptidase M15; Region: Peptidase_M15_3; cl01194
582899000860	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
582899000861	GTP-binding protein LepA; Provisional; Region: PRK05433
582899000862	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
582899000863	G1 box; other site
582899000864	putative GEF interaction site [polypeptide binding]; other site
582899000865	GTP/Mg2+ binding site [chemical binding]; other site
582899000866	Switch I region; other site
582899000867	G2 box; other site
582899000868	G3 box; other site
582899000869	Switch II region; other site
582899000870	G4 box; other site
582899000871	G5 box; other site
582899000872	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
582899000873	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
582899000874	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
582899000875	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
582899000876	diiron binding motif [ion binding]; other site
582899000877	Uncharacterized conserved protein [Function unknown]; Region: COG1633
582899000878	CCC1-related protein family; Region: CCC1_like_1; cd02437
582899000879	Transglycosylase SLT domain; Region: SLT_2; pfam13406
582899000880	murein hydrolase B; Provisional; Region: PRK10760; cl17906
582899000881	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899000882	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
582899000883	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899000884	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
582899000885	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
582899000886	putative tRNA-binding site [nucleotide binding]; other site
582899000887	B3/4 domain; Region: B3_4; pfam03483
582899000888	tRNA synthetase B5 domain; Region: B5; smart00874
582899000889	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
582899000890	dimer interface [polypeptide binding]; other site
582899000891	motif 1; other site
582899000892	motif 3; other site
582899000893	motif 2; other site
582899000894	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
582899000895	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
582899000896	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
582899000897	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
582899000898	dimer interface [polypeptide binding]; other site
582899000899	motif 1; other site
582899000900	active site
582899000901	motif 2; other site
582899000902	motif 3; other site
582899000903	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
582899000904	23S rRNA binding site [nucleotide binding]; other site
582899000905	L21 binding site [polypeptide binding]; other site
582899000906	L13 binding site [polypeptide binding]; other site
582899000907	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
582899000908	Predicted membrane protein [Function unknown]; Region: COG2246
582899000909	GtrA-like protein; Region: GtrA; pfam04138
582899000910	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899000911	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899000912	ligand binding site [chemical binding]; other site
582899000913	flexible hinge region; other site
582899000914	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
582899000915	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
582899000916	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
582899000917	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
582899000918	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
582899000919	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
582899000920	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
582899000921	putative ADP-binding pocket [chemical binding]; other site
582899000922	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
582899000923	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
582899000924	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582899000925	putative NAD(P) binding site [chemical binding]; other site
582899000926	epoxyqueuosine reductase; Region: TIGR00276
582899000927	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
582899000928	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
582899000929	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582899000930	C-terminal domain interface [polypeptide binding]; other site
582899000931	GSH binding site (G-site) [chemical binding]; other site
582899000932	dimer interface [polypeptide binding]; other site
582899000933	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
582899000934	N-terminal domain interface [polypeptide binding]; other site
582899000935	dimer interface [polypeptide binding]; other site
582899000936	substrate binding pocket (H-site) [chemical binding]; other site
582899000937	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
582899000938	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
582899000939	active site
582899000940	phosphorylation site [posttranslational modification]
582899000941	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
582899000942	30S subunit binding site; other site
582899000943	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
582899000944	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
582899000945	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
582899000946	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
582899000947	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
582899000948	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
582899000949	Walker A/P-loop; other site
582899000950	ATP binding site [chemical binding]; other site
582899000951	Q-loop/lid; other site
582899000952	ABC transporter signature motif; other site
582899000953	Walker B; other site
582899000954	D-loop; other site
582899000955	H-loop/switch region; other site
582899000956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
582899000957	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
582899000958	OstA-like protein; Region: OstA; pfam03968
582899000959	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
582899000960	OstA-like protein; Region: OstA; pfam03968
582899000961	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
582899000962	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
582899000963	catalytic site [active]
582899000964	putative active site [active]
582899000965	putative substrate binding site [chemical binding]; other site
582899000966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899000967	binding surface
582899000968	TPR motif; other site
582899000969	Predicted membrane protein [Function unknown]; Region: COG2259
582899000970	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
582899000971	glutaminase; Provisional; Region: PRK00971
582899000972	Autotransporter beta-domain; Region: Autotransporter; smart00869
582899000973	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
582899000974	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
582899000975	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
582899000976	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
582899000977	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
582899000978	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
582899000979	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
582899000980	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582899000981	Sel1-like repeats; Region: SEL1; smart00671
582899000982	Sel1-like repeats; Region: SEL1; smart00671
582899000983	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582899000984	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
582899000985	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
582899000986	putative active site [active]
582899000987	putative metal binding site [ion binding]; other site
582899000988	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
582899000989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899000990	ATP binding site [chemical binding]; other site
582899000991	putative Mg++ binding site [ion binding]; other site
582899000992	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899000993	nucleotide binding region [chemical binding]; other site
582899000994	ATP-binding site [chemical binding]; other site
582899000995	DEAD/H associated; Region: DEAD_assoc; pfam08494
582899000996	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
582899000997	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
582899000998	quinone interaction residues [chemical binding]; other site
582899000999	active site
582899001000	catalytic residues [active]
582899001001	FMN binding site [chemical binding]; other site
582899001002	substrate binding site [chemical binding]; other site
582899001003	Protein of unknown function (DUF952); Region: DUF952; cl01393
582899001004	Protein of unknown function DUF262; Region: DUF262; pfam03235
582899001005	Uncharacterized conserved protein [Function unknown]; Region: COG1479
582899001006	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
582899001007	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
582899001008	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899001009	active site
582899001010	nucleotide binding site [chemical binding]; other site
582899001011	HIGH motif; other site
582899001012	KMSKS motif; other site
582899001013	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
582899001014	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
582899001015	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
582899001016	methionine sulfoxide reductase A; Provisional; Region: PRK00058
582899001017	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
582899001018	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
582899001019	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
582899001020	Predicted deacylase [General function prediction only]; Region: COG3608
582899001021	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
582899001022	active site
582899001023	Zn binding site [ion binding]; other site
582899001024	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
582899001025	Transposase, Mutator family; Region: Transposase_mut; pfam00872
582899001026	MULE transposase domain; Region: MULE; pfam10551
582899001027	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
582899001028	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
582899001029	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899001030	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
582899001031	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582899001032	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582899001033	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
582899001034	transcriptional activator RfaH; Region: RfaH; TIGR01955
582899001035	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
582899001036	heterodimer interface [polypeptide binding]; other site
582899001037	homodimer interface [polypeptide binding]; other site
582899001038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001039	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
582899001040	Uncharacterized conserved protein [Function unknown]; Region: COG1434
582899001041	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
582899001042	putative active site [active]
582899001043	putative acyl transferase; Provisional; Region: PRK10502
582899001044	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
582899001045	putative trimer interface [polypeptide binding]; other site
582899001046	putative active site [active]
582899001047	putative substrate binding site [chemical binding]; other site
582899001048	putative CoA binding site [chemical binding]; other site
582899001049	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001050	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
582899001051	putative ADP-binding pocket [chemical binding]; other site
582899001052	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582899001053	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001054	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
582899001055	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582899001056	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001057	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001058	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582899001059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001060	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
582899001061	putative ADP-binding pocket [chemical binding]; other site
582899001062	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
582899001063	putative ADP-binding pocket [chemical binding]; other site
582899001064	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001065	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582899001066	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
582899001067	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
582899001068	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
582899001069	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899001070	putative ADP-binding pocket [chemical binding]; other site
582899001071	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
582899001072	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
582899001073	Chain length determinant protein; Region: Wzz; cl15801
582899001074	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
582899001075	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
582899001076	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899001077	PHP domain; Region: PHP; pfam02811
582899001078	O-Antigen ligase; Region: Wzy_C; pfam04932
582899001079	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
582899001080	Bacterial sugar transferase; Region: Bac_transf; pfam02397
582899001081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
582899001082	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582899001083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582899001084	DNA-binding site [nucleotide binding]; DNA binding site
582899001085	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899001086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899001087	homodimer interface [polypeptide binding]; other site
582899001088	catalytic residue [active]
582899001089	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
582899001090	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582899001091	putative NAD(P) binding site [chemical binding]; other site
582899001092	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
582899001093	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
582899001094	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
582899001095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899001096	dimer interface [polypeptide binding]; other site
582899001097	conserved gate region; other site
582899001098	putative PBP binding loops; other site
582899001099	ABC-ATPase subunit interface; other site
582899001100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899001101	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
582899001102	Walker A/P-loop; other site
582899001103	ATP binding site [chemical binding]; other site
582899001104	Q-loop/lid; other site
582899001105	ABC transporter signature motif; other site
582899001106	Walker B; other site
582899001107	D-loop; other site
582899001108	H-loop/switch region; other site
582899001109	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
582899001110	ABC-2 type transporter; Region: ABC2_membrane; cl17235
582899001111	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
582899001112	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
582899001113	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
582899001114	Walker A/P-loop; other site
582899001115	ATP binding site [chemical binding]; other site
582899001116	Q-loop/lid; other site
582899001117	ABC transporter signature motif; other site
582899001118	Walker B; other site
582899001119	D-loop; other site
582899001120	H-loop/switch region; other site
582899001121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899001122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899001123	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
582899001124	NHL repeat; Region: NHL; pfam01436
582899001125	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
582899001126	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
582899001127	putative NADP binding site [chemical binding]; other site
582899001128	putative substrate binding site [chemical binding]; other site
582899001129	active site
582899001130	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
582899001131	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
582899001132	active site
582899001133	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
582899001134	substrate binding pocket [chemical binding]; other site
582899001135	substrate-Mg2+ binding site; other site
582899001136	aspartate-rich region 1; other site
582899001137	aspartate-rich region 2; other site
582899001138	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
582899001139	active site lid residues [active]
582899001140	substrate binding pocket [chemical binding]; other site
582899001141	catalytic residues [active]
582899001142	substrate-Mg2+ binding site; other site
582899001143	aspartate-rich region 1; other site
582899001144	aspartate-rich region 2; other site
582899001145	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899001146	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
582899001147	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
582899001148	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
582899001149	Active site cavity [active]
582899001150	catalytic acid [active]
582899001151	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
582899001152	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
582899001153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001154	FeS/SAM binding site; other site
582899001155	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
582899001156	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
582899001157	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
582899001158	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
582899001159	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
582899001160	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
582899001161	B12 binding site [chemical binding]; other site
582899001162	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001163	FeS/SAM binding site; other site
582899001164	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
582899001165	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
582899001166	ligand binding site; other site
582899001167	VacJ like lipoprotein; Region: VacJ; cl01073
582899001168	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
582899001169	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
582899001170	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
582899001171	TPP-binding site; other site
582899001172	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582899001173	PYR/PP interface [polypeptide binding]; other site
582899001174	dimer interface [polypeptide binding]; other site
582899001175	TPP binding site [chemical binding]; other site
582899001176	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582899001177	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
582899001178	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
582899001179	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
582899001180	ligand binding site; other site
582899001181	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
582899001182	putative active site [active]
582899001183	YdjC motif; other site
582899001184	Mg binding site [ion binding]; other site
582899001185	putative homodimer interface [polypeptide binding]; other site
582899001186	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
582899001187	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
582899001188	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
582899001189	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582899001190	catalytic core [active]
582899001191	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
582899001192	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
582899001193	DXD motif; other site
582899001194	PilZ domain; Region: PilZ; pfam07238
582899001195	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
582899001196	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899001197	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
582899001198	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582899001199	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582899001200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899001201	Walker A/P-loop; other site
582899001202	ATP binding site [chemical binding]; other site
582899001203	Q-loop/lid; other site
582899001204	ABC transporter signature motif; other site
582899001205	Walker B; other site
582899001206	D-loop; other site
582899001207	H-loop/switch region; other site
582899001208	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
582899001209	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
582899001210	substrate binding site; other site
582899001211	tetramer interface; other site
582899001212	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
582899001213	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
582899001214	NAD binding site [chemical binding]; other site
582899001215	substrate binding site [chemical binding]; other site
582899001216	homodimer interface [polypeptide binding]; other site
582899001217	active site
582899001218	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
582899001219	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
582899001220	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
582899001221	Cupin domain; Region: Cupin_2; cl17218
582899001222	SPW repeat; Region: SPW; pfam03779
582899001223	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
582899001224	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
582899001225	FAD binding pocket [chemical binding]; other site
582899001226	FAD binding motif [chemical binding]; other site
582899001227	phosphate binding motif [ion binding]; other site
582899001228	beta-alpha-beta structure motif; other site
582899001229	NAD binding pocket [chemical binding]; other site
582899001230	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
582899001231	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
582899001232	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
582899001233	putative active site [active]
582899001234	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
582899001235	domain_subunit interface; other site
582899001236	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
582899001237	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
582899001238	active site
582899001239	FMN binding site [chemical binding]; other site
582899001240	substrate binding site [chemical binding]; other site
582899001241	3Fe-4S cluster binding site [ion binding]; other site
582899001242	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
582899001243	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582899001244	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
582899001245	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
582899001246	catalytic triad [active]
582899001247	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582899001248	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899001249	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582899001250	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582899001251	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
582899001252	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
582899001253	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
582899001254	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582899001255	endonuclease III; Region: ENDO3c; smart00478
582899001256	minor groove reading motif; other site
582899001257	helix-hairpin-helix signature motif; other site
582899001258	substrate binding pocket [chemical binding]; other site
582899001259	active site
582899001260	methionine sulfoxide reductase B; Provisional; Region: PRK00222
582899001261	SelR domain; Region: SelR; pfam01641
582899001262	Putative zinc-finger; Region: zf-HC2; pfam13490
582899001263	RNA polymerase sigma factor; Provisional; Region: PRK12520
582899001264	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899001265	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899001266	DNA binding residues [nucleotide binding]
582899001267	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
582899001268	putative heme binding pocket [chemical binding]; other site
582899001269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899001270	metabolite-proton symporter; Region: 2A0106; TIGR00883
582899001271	putative substrate translocation pore; other site
582899001272	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899001273	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
582899001274	SLBB domain; Region: SLBB; pfam10531
582899001275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899001276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899001277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899001278	dimerization interface [polypeptide binding]; other site
582899001279	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
582899001280	glutamate dehydrogenase; Provisional; Region: PRK09414
582899001281	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
582899001282	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
582899001283	NAD(P) binding site [chemical binding]; other site
582899001284	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899001285	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
582899001286	putative ligand binding site [chemical binding]; other site
582899001287	Transcriptional regulators [Transcription]; Region: FadR; COG2186
582899001288	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582899001289	DNA-binding site [nucleotide binding]; DNA binding site
582899001290	FCD domain; Region: FCD; pfam07729
582899001291	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
582899001292	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
582899001293	FMN binding site [chemical binding]; other site
582899001294	active site
582899001295	homodimer interface [polypeptide binding]; other site
582899001296	putative catalytic residue [active]
582899001297	4Fe-4S cluster binding site [ion binding]; other site
582899001298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582899001299	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
582899001300	4Fe-4S binding domain; Region: Fer4; cl02805
582899001301	Cysteine-rich domain; Region: CCG; pfam02754
582899001302	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582899001303	Ligand binding site [chemical binding]; other site
582899001304	Electron transfer flavoprotein domain; Region: ETF; pfam01012
582899001305	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
582899001306	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582899001307	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582899001308	Amino acid permease; Region: AA_permease_2; pfam13520
582899001309	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
582899001310	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582899001311	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582899001312	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899001313	N-terminal plug; other site
582899001314	ligand-binding site [chemical binding]; other site
582899001315	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
582899001316	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
582899001317	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
582899001318	NnrS protein; Region: NnrS; pfam05940
582899001319	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
582899001320	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582899001321	phosphate binding site [ion binding]; other site
582899001322	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
582899001323	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899001324	catalytic residue [active]
582899001325	Protein of unknown function (DUF989); Region: DUF989; pfam06181
582899001326	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
582899001327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001328	FeS/SAM binding site; other site
582899001329	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
582899001330	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
582899001331	PqqA family; Region: PqqA; cl15372
582899001332	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
582899001333	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582899001334	dimer interface [polypeptide binding]; other site
582899001335	active site
582899001336	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
582899001337	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
582899001338	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
582899001339	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582899001340	NAD(P) binding site [chemical binding]; other site
582899001341	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
582899001342	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582899001343	dimer interface [polypeptide binding]; other site
582899001344	active site
582899001345	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
582899001346	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
582899001347	active site
582899001348	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
582899001349	acyl carrier protein; Provisional; Region: PRK06508
582899001350	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
582899001351	dimer interaction site [polypeptide binding]; other site
582899001352	substrate-binding tunnel; other site
582899001353	active site
582899001354	catalytic site [active]
582899001355	substrate binding site [chemical binding]; other site
582899001356	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582899001357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899001358	NAD(P) binding site [chemical binding]; other site
582899001359	active site
582899001360	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
582899001361	Acid Phosphatase; Region: Acid_PPase; cl17256
582899001362	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
582899001363	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
582899001364	Flavoprotein; Region: Flavoprotein; pfam02441
582899001365	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
582899001366	SCP-2 sterol transfer family; Region: SCP2; cl01225
582899001367	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
582899001368	Peptidase family U32; Region: Peptidase_U32; pfam01136
582899001369	putative protease; Provisional; Region: PRK15447
582899001370	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
582899001371	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582899001372	Cytochrome P450; Region: p450; cl12078
582899001373	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
582899001374	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899001375	ligand binding site [chemical binding]; other site
582899001376	flexible hinge region; other site
582899001377	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
582899001378	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
582899001379	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
582899001380	4Fe-4S binding domain; Region: Fer4_5; pfam12801
582899001381	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
582899001382	Fe2+ transport protein; Region: Iron_transport; pfam10634
582899001383	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
582899001384	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001385	FeS/SAM binding site; other site
582899001386	HemN C-terminal domain; Region: HemN_C; pfam06969
582899001387	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
582899001388	Subunit I/III interface [polypeptide binding]; other site
582899001389	Cytochrome c; Region: Cytochrom_C; pfam00034
582899001390	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
582899001391	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
582899001392	Low-spin heme binding site [chemical binding]; other site
582899001393	D-pathway; other site
582899001394	K-pathway; other site
582899001395	Binuclear center (active site) [active]
582899001396	Putative proton exit pathway; other site
582899001397	MoxR-like ATPases [General function prediction only]; Region: COG0714
582899001398	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
582899001399	Walker A motif; other site
582899001400	ATP binding site [chemical binding]; other site
582899001401	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
582899001402	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
582899001403	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
582899001404	metal ion-dependent adhesion site (MIDAS); other site
582899001405	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582899001406	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899001407	NnrS protein; Region: NnrS; pfam05940
582899001408	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
582899001409	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
582899001410	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
582899001411	Protein required for attachment to host cells; Region: Host_attach; pfam10116
582899001412	PAS domain S-box; Region: sensory_box; TIGR00229
582899001413	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001414	putative active site [active]
582899001415	heme pocket [chemical binding]; other site
582899001416	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582899001417	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001418	putative active site [active]
582899001419	heme pocket [chemical binding]; other site
582899001420	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899001421	dimer interface [polypeptide binding]; other site
582899001422	phosphorylation site [posttranslational modification]
582899001423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899001424	ATP binding site [chemical binding]; other site
582899001425	Mg2+ binding site [ion binding]; other site
582899001426	G-X-G motif; other site
582899001427	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899001428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001429	active site
582899001430	phosphorylation site [posttranslational modification]
582899001431	intermolecular recognition site; other site
582899001432	osmolarity response regulator; Provisional; Region: ompR; PRK09468
582899001433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001434	active site
582899001435	phosphorylation site [posttranslational modification]
582899001436	intermolecular recognition site; other site
582899001437	dimerization interface [polypeptide binding]; other site
582899001438	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899001439	DNA binding site [nucleotide binding]
582899001440	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899001441	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899001442	ligand binding site [chemical binding]; other site
582899001443	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
582899001444	putative switch regulator; other site
582899001445	non-specific DNA interactions [nucleotide binding]; other site
582899001446	DNA binding site [nucleotide binding]
582899001447	sequence specific DNA binding site [nucleotide binding]; other site
582899001448	putative cAMP binding site [chemical binding]; other site
582899001449	PAS domain S-box; Region: sensory_box; TIGR00229
582899001450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001451	putative active site [active]
582899001452	heme pocket [chemical binding]; other site
582899001453	PAS fold; Region: PAS_3; pfam08447
582899001454	Histidine kinase; Region: HisKA_3; pfam07730
582899001455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899001456	ATP binding site [chemical binding]; other site
582899001457	Mg2+ binding site [ion binding]; other site
582899001458	G-X-G motif; other site
582899001459	transcriptional regulator NarL; Provisional; Region: PRK10651
582899001460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001461	active site
582899001462	phosphorylation site [posttranslational modification]
582899001463	intermolecular recognition site; other site
582899001464	dimerization interface [polypeptide binding]; other site
582899001465	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899001466	DNA binding residues [nucleotide binding]
582899001467	dimerization interface [polypeptide binding]; other site
582899001468	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
582899001469	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001470	FeS/SAM binding site; other site
582899001471	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
582899001472	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
582899001473	NADH(P)-binding; Region: NAD_binding_10; pfam13460
582899001474	NAD(P) binding site [chemical binding]; other site
582899001475	putative active site [active]
582899001476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001477	PAS domain; Region: PAS_9; pfam13426
582899001478	putative active site [active]
582899001479	heme pocket [chemical binding]; other site
582899001480	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582899001481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582899001482	dimer interface [polypeptide binding]; other site
582899001483	putative CheW interface [polypeptide binding]; other site
582899001484	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
582899001485	putative CheA interaction surface; other site
582899001486	cyanate hydratase; Validated; Region: PRK02866
582899001487	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
582899001488	oligomer interface [polypeptide binding]; other site
582899001489	active site
582899001490	formate dehydrogenase; Provisional; Region: PRK07574
582899001491	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
582899001492	dimerization interface [polypeptide binding]; other site
582899001493	ligand binding site [chemical binding]; other site
582899001494	NAD binding site [chemical binding]; other site
582899001495	catalytic site [active]
582899001496	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899001497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899001498	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899001499	dimerization interface [polypeptide binding]; other site
582899001500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899001501	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
582899001502	Walker A motif; other site
582899001503	ATP binding site [chemical binding]; other site
582899001504	Walker B motif; other site
582899001505	arginine finger; other site
582899001506	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582899001507	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
582899001508	heme-binding site [chemical binding]; other site
582899001509	Cupin domain; Region: Cupin_2; cl17218
582899001510	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
582899001511	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
582899001512	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
582899001513	Uncharacterized conserved protein [Function unknown]; Region: COG2127
582899001514	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
582899001515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899001516	Walker A motif; other site
582899001517	ATP binding site [chemical binding]; other site
582899001518	Walker B motif; other site
582899001519	arginine finger; other site
582899001520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899001521	Walker A motif; other site
582899001522	ATP binding site [chemical binding]; other site
582899001523	Walker B motif; other site
582899001524	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582899001525	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
582899001526	NADH(P)-binding; Region: NAD_binding_10; pfam13460
582899001527	NAD binding site [chemical binding]; other site
582899001528	substrate binding site [chemical binding]; other site
582899001529	putative active site [active]
582899001530	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
582899001531	HIT family signature motif; other site
582899001532	catalytic residue [active]
582899001533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
582899001534	Protein of unknown function, DUF482; Region: DUF482; pfam04339
582899001535	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
582899001536	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
582899001537	active site
582899001538	catalytic site [active]
582899001539	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
582899001540	homotrimer interaction site [polypeptide binding]; other site
582899001541	putative active site [active]
582899001542	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
582899001543	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
582899001544	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899001545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001546	active site
582899001547	phosphorylation site [posttranslational modification]
582899001548	intermolecular recognition site; other site
582899001549	dimerization interface [polypeptide binding]; other site
582899001550	response regulator PleD; Reviewed; Region: pleD; PRK09581
582899001551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001552	active site
582899001553	phosphorylation site [posttranslational modification]
582899001554	intermolecular recognition site; other site
582899001555	dimerization interface [polypeptide binding]; other site
582899001556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001557	active site
582899001558	phosphorylation site [posttranslational modification]
582899001559	intermolecular recognition site; other site
582899001560	dimerization interface [polypeptide binding]; other site
582899001561	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899001562	metal binding site [ion binding]; metal-binding site
582899001563	active site
582899001564	I-site; other site
582899001565	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
582899001566	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
582899001567	nudix motif; other site
582899001568	Protein of unknown function (DUF983); Region: DUF983; cl02211
582899001569	ribonuclease R; Region: RNase_R; TIGR02063
582899001570	RNB domain; Region: RNB; pfam00773
582899001571	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
582899001572	RNA binding site [nucleotide binding]; other site
582899001573	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
582899001574	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
582899001575	active site
582899001576	interdomain interaction site; other site
582899001577	putative metal-binding site [ion binding]; other site
582899001578	nucleotide binding site [chemical binding]; other site
582899001579	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
582899001580	domain I; other site
582899001581	DNA binding groove [nucleotide binding]
582899001582	phosphate binding site [ion binding]; other site
582899001583	domain II; other site
582899001584	domain III; other site
582899001585	nucleotide binding site [chemical binding]; other site
582899001586	catalytic site [active]
582899001587	domain IV; other site
582899001588	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
582899001589	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582899001590	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582899001591	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
582899001592	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
582899001593	DNA protecting protein DprA; Region: dprA; TIGR00732
582899001594	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
582899001595	dihydroorotase; Validated; Region: PRK09059
582899001596	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582899001597	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
582899001598	active site
582899001599	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
582899001600	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
582899001601	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
582899001602	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
582899001603	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
582899001604	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
582899001605	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
582899001606	Chorismate mutase type II; Region: CM_2; smart00830
582899001607	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
582899001608	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
582899001609	GatB domain; Region: GatB_Yqey; smart00845
582899001610	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582899001611	Cytochrome P450; Region: p450; cl12078
582899001612	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
582899001613	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
582899001614	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
582899001615	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
582899001616	NADP binding site [chemical binding]; other site
582899001617	dimer interface [polypeptide binding]; other site
582899001618	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
582899001619	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
582899001620	C-terminal domain interface [polypeptide binding]; other site
582899001621	GSH binding site (G-site) [chemical binding]; other site
582899001622	dimer interface [polypeptide binding]; other site
582899001623	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
582899001624	N-terminal domain interface [polypeptide binding]; other site
582899001625	dimer interface [polypeptide binding]; other site
582899001626	substrate binding pocket (H-site) [chemical binding]; other site
582899001627	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582899001628	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
582899001629	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
582899001630	metal binding triad [ion binding]; metal-binding site
582899001631	integrase; Provisional; Region: PRK09692
582899001632	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582899001633	active site
582899001634	Int/Topo IB signature motif; other site
582899001635	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
582899001636	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
582899001637	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
582899001638	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
582899001639	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899001640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899001641	homodimer interface [polypeptide binding]; other site
582899001642	catalytic residue [active]
582899001643	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582899001644	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899001645	N-terminal plug; other site
582899001646	ligand-binding site [chemical binding]; other site
582899001647	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582899001648	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
582899001649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899001650	dimer interface [polypeptide binding]; other site
582899001651	conserved gate region; other site
582899001652	putative PBP binding loops; other site
582899001653	ABC-ATPase subunit interface; other site
582899001654	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582899001655	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
582899001656	Walker A/P-loop; other site
582899001657	ATP binding site [chemical binding]; other site
582899001658	Q-loop/lid; other site
582899001659	ABC transporter signature motif; other site
582899001660	Walker B; other site
582899001661	D-loop; other site
582899001662	H-loop/switch region; other site
582899001663	NnrS protein; Region: NnrS; pfam05940
582899001664	NnrS protein; Region: NnrS; pfam05940
582899001665	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
582899001666	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
582899001667	catalytic residues [active]
582899001668	Putative phosphatase (DUF442); Region: DUF442; cl17385
582899001669	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
582899001670	Predicted transporter component [General function prediction only]; Region: COG2391
582899001671	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899001672	dimerization interface [polypeptide binding]; other site
582899001673	putative DNA binding site [nucleotide binding]; other site
582899001674	putative Zn2+ binding site [ion binding]; other site
582899001675	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
582899001676	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001677	FeS/SAM binding site; other site
582899001678	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
582899001679	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
582899001680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899001681	FeS/SAM binding site; other site
582899001682	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
582899001683	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
582899001684	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
582899001685	conserved cys residue [active]
582899001686	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
582899001687	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
582899001688	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
582899001689	Cysteine-rich domain; Region: CCG; pfam02754
582899001690	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
582899001691	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
582899001692	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
582899001693	Cysteine-rich domain; Region: CCG; pfam02754
582899001694	Cysteine-rich domain; Region: CCG; pfam02754
582899001695	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
582899001696	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
582899001697	lipoyl attachment site [posttranslational modification]; other site
582899001698	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582899001699	Cytochrome P450; Region: p450; cl12078
582899001700	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
582899001701	CPxP  motif; other site
582899001702	Sulphur transport; Region: Sulf_transp; pfam04143
582899001703	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899001704	dimerization interface [polypeptide binding]; other site
582899001705	putative DNA binding site [nucleotide binding]; other site
582899001706	putative Zn2+ binding site [ion binding]; other site
582899001707	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899001708	Cytochrome c; Region: Cytochrom_C; pfam00034
582899001709	Cytochrome c; Region: Cytochrom_C; pfam00034
582899001710	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
582899001711	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
582899001712	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582899001713	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
582899001714	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
582899001715	active site
582899001716	metal binding site [ion binding]; metal-binding site
582899001717	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
582899001718	Transposase, Mutator family; Region: Transposase_mut; pfam00872
582899001719	MULE transposase domain; Region: MULE; pfam10551
582899001720	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
582899001721	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
582899001722	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
582899001723	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
582899001724	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
582899001725	DNA binding residues [nucleotide binding]
582899001726	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
582899001727	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582899001728	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899001729	C-terminal, alpha helical domain of Class Theta Glutathione S-transferases; Region: GST_C_Theta; cd03183
582899001730	dimer interface [polypeptide binding]; other site
582899001731	substrate binding pocket (H-site) [chemical binding]; other site
582899001732	N-terminal domain interface [polypeptide binding]; other site
582899001733	Transposase, Mutator family; Region: Transposase_mut; pfam00872
582899001734	MULE transposase domain; Region: MULE; pfam10551
582899001735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899001736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899001737	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899001738	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899001739	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899001740	dimerization interface [polypeptide binding]; other site
582899001741	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
582899001742	Protein of unknown function (DUF1308); Region: DUF1308; pfam07000
582899001743	Putative phosphatase (DUF442); Region: DUF442; cl17385
582899001744	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582899001745	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
582899001746	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899001747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001748	active site
582899001749	phosphorylation site [posttranslational modification]
582899001750	intermolecular recognition site; other site
582899001751	dimerization interface [polypeptide binding]; other site
582899001752	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899001753	DNA binding residues [nucleotide binding]
582899001754	dimerization interface [polypeptide binding]; other site
582899001755	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
582899001756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001757	active site
582899001758	phosphorylation site [posttranslational modification]
582899001759	intermolecular recognition site; other site
582899001760	dimerization interface [polypeptide binding]; other site
582899001761	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899001762	DNA binding residues [nucleotide binding]
582899001763	dimerization interface [polypeptide binding]; other site
582899001764	PAS fold; Region: PAS_4; pfam08448
582899001765	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001766	putative active site [active]
582899001767	heme pocket [chemical binding]; other site
582899001768	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582899001769	GAF domain; Region: GAF; pfam01590
582899001770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899001771	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582899001772	putative active site [active]
582899001773	heme pocket [chemical binding]; other site
582899001774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899001775	dimer interface [polypeptide binding]; other site
582899001776	phosphorylation site [posttranslational modification]
582899001777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899001778	ATP binding site [chemical binding]; other site
582899001779	Mg2+ binding site [ion binding]; other site
582899001780	G-X-G motif; other site
582899001781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582899001782	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
582899001783	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
582899001784	active site
582899001785	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
582899001786	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582899001787	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
582899001788	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
582899001789	dimer interface [polypeptide binding]; other site
582899001790	decamer (pentamer of dimers) interface [polypeptide binding]; other site
582899001791	catalytic triad [active]
582899001792	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
582899001793	Fatty acid desaturase; Region: FA_desaturase; pfam00487
582899001794	putative di-iron ligands [ion binding]; other site
582899001795	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
582899001796	heme-binding site [chemical binding]; other site
582899001797	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
582899001798	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582899001799	catalytic loop [active]
582899001800	iron binding site [ion binding]; other site
582899001801	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
582899001802	FAD binding pocket [chemical binding]; other site
582899001803	conserved FAD binding motif [chemical binding]; other site
582899001804	phosphate binding motif [ion binding]; other site
582899001805	beta-alpha-beta structure motif; other site
582899001806	NAD binding pocket [chemical binding]; other site
582899001807	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582899001808	metal binding site 2 [ion binding]; metal-binding site
582899001809	putative DNA binding helix; other site
582899001810	metal binding site 1 [ion binding]; metal-binding site
582899001811	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
582899001812	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
582899001813	hypothetical protein; Validated; Region: PRK07581
582899001814	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
582899001815	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582899001816	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
582899001817	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899001818	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
582899001819	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
582899001820	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582899001821	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899001822	N-terminal plug; other site
582899001823	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
582899001824	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
582899001825	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
582899001826	active site
582899001827	DNA polymerase IV; Validated; Region: PRK02406
582899001828	DNA binding site [nucleotide binding]
582899001829	Uncharacterized conserved protein [Function unknown]; Region: COG4544
582899001830	DNA Polymerase Y-family; Region: PolY_like; cd03468
582899001831	active site
582899001832	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
582899001833	DNA binding site [nucleotide binding]
582899001834	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
582899001835	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
582899001836	putative active site [active]
582899001837	putative PHP Thumb interface [polypeptide binding]; other site
582899001838	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
582899001839	generic binding surface II; other site
582899001840	generic binding surface I; other site
582899001841	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
582899001842	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
582899001843	serine O-acetyltransferase; Region: cysE; TIGR01172
582899001844	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
582899001845	trimer interface [polypeptide binding]; other site
582899001846	active site
582899001847	substrate binding site [chemical binding]; other site
582899001848	CoA binding site [chemical binding]; other site
582899001849	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582899001850	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
582899001851	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899001852	catalytic residue [active]
582899001853	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899001854	CheB methylesterase; Region: CheB_methylest; pfam01339
582899001855	CheB methylesterase; Region: CheB_methylest; pfam01339
582899001856	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
582899001857	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582899001858	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
582899001859	PAS domain; Region: PAS_10; pfam13596
582899001860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899001861	HWE histidine kinase; Region: HWE_HK; smart00911
582899001862	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899001863	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
582899001864	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
582899001865	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
582899001866	GAF domain; Region: GAF; pfam01590
582899001867	Phytochrome region; Region: PHY; pfam00360
582899001868	HWE histidine kinase; Region: HWE_HK; pfam07536
582899001869	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899001870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899001871	active site
582899001872	phosphorylation site [posttranslational modification]
582899001873	intermolecular recognition site; other site
582899001874	dimerization interface [polypeptide binding]; other site
582899001875	SnoaL-like domain; Region: SnoaL_3; pfam13474
582899001876	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
582899001877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899001878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899001879	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
582899001880	homotrimer interaction site [polypeptide binding]; other site
582899001881	putative active site [active]
582899001882	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
582899001883	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
582899001884	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
582899001885	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582899001886	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
582899001887	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
582899001888	putative active site [active]
582899001889	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
582899001890	domain_subunit interface; other site
582899001891	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
582899001892	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
582899001893	active site
582899001894	FMN binding site [chemical binding]; other site
582899001895	substrate binding site [chemical binding]; other site
582899001896	3Fe-4S cluster binding site [ion binding]; other site
582899001897	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899001898	non-specific DNA binding site [nucleotide binding]; other site
582899001899	salt bridge; other site
582899001900	sequence-specific DNA binding site [nucleotide binding]; other site
582899001901	Cupin domain; Region: Cupin_2; pfam07883
582899001902	Amino acid permease; Region: AA_permease_2; pfam13520
582899001903	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899001904	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
582899001905	substrate binding pocket [chemical binding]; other site
582899001906	membrane-bound complex binding site; other site
582899001907	hinge residues; other site
582899001908	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
582899001909	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
582899001910	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
582899001911	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899001912	Trp docking motif [polypeptide binding]; other site
582899001913	active site
582899001914	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
582899001915	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
582899001916	tetramer interface [polypeptide binding]; other site
582899001917	TPP-binding site [chemical binding]; other site
582899001918	heterodimer interface [polypeptide binding]; other site
582899001919	phosphorylation loop region [posttranslational modification]
582899001920	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
582899001921	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
582899001922	alpha subunit interface [polypeptide binding]; other site
582899001923	TPP binding site [chemical binding]; other site
582899001924	heterodimer interface [polypeptide binding]; other site
582899001925	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582899001926	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
582899001927	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582899001928	E3 interaction surface; other site
582899001929	lipoyl attachment site [posttranslational modification]; other site
582899001930	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
582899001931	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
582899001932	catalytic site [active]
582899001933	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
582899001934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899001935	Walker A motif; other site
582899001936	ATP binding site [chemical binding]; other site
582899001937	Walker B motif; other site
582899001938	arginine finger; other site
582899001939	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582899001940	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
582899001941	ThiS interaction site; other site
582899001942	putative active site [active]
582899001943	tetramer interface [polypeptide binding]; other site
582899001944	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
582899001945	thiS-thiF/thiG interaction site; other site
582899001946	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
582899001947	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899001948	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899001949	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899001950	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899001951	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
582899001952	ThiC-associated domain; Region: ThiC-associated; pfam13667
582899001953	ThiC family; Region: ThiC; pfam01964
582899001954	Cytochrome c; Region: Cytochrom_C; cl11414
582899001955	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899001956	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
582899001957	dimer interface [polypeptide binding]; other site
582899001958	Trp docking motif [polypeptide binding]; other site
582899001959	active site
582899001960	oxidoreductase; Provisional; Region: PRK12742
582899001961	classical (c) SDRs; Region: SDR_c; cd05233
582899001962	NAD(P) binding site [chemical binding]; other site
582899001963	active site
582899001964	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582899001965	Protein export membrane protein; Region: SecD_SecF; cl14618
582899001966	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
582899001967	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899001968	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899001969	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899001970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899001971	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899001972	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
582899001973	active site
582899001974	nucleophile elbow; other site
582899001975	Patatin phospholipase; Region: DUF3734; pfam12536
582899001976	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
582899001977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899001978	NAD(P) binding site [chemical binding]; other site
582899001979	active site
582899001980	acetoacetate decarboxylase; Provisional; Region: PRK02265
582899001981	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
582899001982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899001983	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
582899001984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899001985	putative substrate translocation pore; other site
582899001986	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
582899001987	dimer interface [polypeptide binding]; other site
582899001988	putative radical transfer pathway; other site
582899001989	diiron center [ion binding]; other site
582899001990	tyrosyl radical; other site
582899001991	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
582899001992	ATP cone domain; Region: ATP-cone; pfam03477
582899001993	ATP cone domain; Region: ATP-cone; pfam03477
582899001994	Class I ribonucleotide reductase; Region: RNR_I; cd01679
582899001995	active site
582899001996	dimer interface [polypeptide binding]; other site
582899001997	catalytic residues [active]
582899001998	effector binding site; other site
582899001999	R2 peptide binding site; other site
582899002000	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
582899002001	Citrate synthase; Region: Citrate_synt; pfam00285
582899002002	oxalacetate binding site [chemical binding]; other site
582899002003	citrylCoA binding site [chemical binding]; other site
582899002004	coenzyme A binding site [chemical binding]; other site
582899002005	catalytic triad [active]
582899002006	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899002007	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
582899002008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899002009	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582899002010	dimerization interface [polypeptide binding]; other site
582899002011	Cupin domain; Region: Cupin_2; pfam07883
582899002012	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899002013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899002014	active site
582899002015	phosphorylation site [posttranslational modification]
582899002016	intermolecular recognition site; other site
582899002017	dimerization interface [polypeptide binding]; other site
582899002018	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899002019	DNA binding residues [nucleotide binding]
582899002020	dimerization interface [polypeptide binding]; other site
582899002021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
582899002022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
582899002023	Histidine kinase; Region: HisKA_3; pfam07730
582899002024	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
582899002025	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
582899002026	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
582899002027	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582899002028	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582899002029	dimer interface [polypeptide binding]; other site
582899002030	putative CheW interface [polypeptide binding]; other site
582899002031	Phosphate transporter family; Region: PHO4; pfam01384
582899002032	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
582899002033	exopolyphosphatase; Region: exo_poly_only; TIGR03706
582899002034	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
582899002035	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
582899002036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899002037	S-adenosylmethionine binding site [chemical binding]; other site
582899002038	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
582899002039	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582899002040	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
582899002041	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
582899002042	active site
582899002043	MAPEG family; Region: MAPEG; cl09190
582899002044	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
582899002045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899002046	SET domain; Region: SET; pfam00856
582899002047	SET domain; Region: SET; pfam00856
582899002048	TspO/MBR family; Region: TspO_MBR; pfam03073
582899002049	GMP synthase; Reviewed; Region: guaA; PRK00074
582899002050	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
582899002051	AMP/PPi binding site [chemical binding]; other site
582899002052	candidate oxyanion hole; other site
582899002053	catalytic triad [active]
582899002054	potential glutamine specificity residues [chemical binding]; other site
582899002055	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
582899002056	ATP Binding subdomain [chemical binding]; other site
582899002057	Ligand Binding sites [chemical binding]; other site
582899002058	Dimerization subdomain; other site
582899002059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
582899002060	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582899002061	Predicted membrane protein [Function unknown]; Region: COG2855
582899002062	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
582899002063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899002064	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
582899002065	putative dimerization interface [polypeptide binding]; other site
582899002066	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
582899002067	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
582899002068	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582899002069	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582899002070	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
582899002071	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
582899002072	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582899002073	carboxyltransferase (CT) interaction site; other site
582899002074	biotinylation site [posttranslational modification]; other site
582899002075	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
582899002076	Dehydroquinase class II; Region: DHquinase_II; pfam01220
582899002077	trimer interface [polypeptide binding]; other site
582899002078	active site
582899002079	dimer interface [polypeptide binding]; other site
582899002080	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
582899002081	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
582899002082	catalytic residues [active]
582899002083	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
582899002084	Peptidase family M48; Region: Peptidase_M48; cl12018
582899002085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002086	binding surface
582899002087	TPR motif; other site
582899002088	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
582899002089	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582899002090	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
582899002091	AMIN domain; Region: AMIN; pfam11741
582899002092	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
582899002093	active site
582899002094	metal binding site [ion binding]; metal-binding site
582899002095	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
582899002096	Transglycosylase; Region: Transgly; pfam00912
582899002097	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582899002098	peptide chain release factor 2; Validated; Region: prfB; PRK00578
582899002099	This domain is found in peptide chain release factors; Region: PCRF; smart00937
582899002100	RF-1 domain; Region: RF-1; pfam00472
582899002101	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
582899002102	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
582899002103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899002104	S-adenosylmethionine binding site [chemical binding]; other site
582899002105	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
582899002106	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
582899002107	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
582899002108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899002109	S-adenosylmethionine binding site [chemical binding]; other site
582899002110	NnrU protein; Region: NnrU; pfam07298
582899002111	BNR repeat-like domain; Region: BNR_2; pfam13088
582899002112	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
582899002113	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899002114	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
582899002115	oligomerization interface [polypeptide binding]; other site
582899002116	active site
582899002117	metal binding site [ion binding]; metal-binding site
582899002118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
582899002119	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
582899002120	Trp docking motif [polypeptide binding]; other site
582899002121	active site
582899002122	PQQ-like domain; Region: PQQ_2; pfam13360
582899002123	PQQ-like domain; Region: PQQ_2; pfam13360
582899002124	GTP-binding protein Der; Reviewed; Region: PRK00093
582899002125	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
582899002126	G1 box; other site
582899002127	GTP/Mg2+ binding site [chemical binding]; other site
582899002128	Switch I region; other site
582899002129	G2 box; other site
582899002130	Switch II region; other site
582899002131	G3 box; other site
582899002132	G4 box; other site
582899002133	G5 box; other site
582899002134	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
582899002135	G1 box; other site
582899002136	GTP/Mg2+ binding site [chemical binding]; other site
582899002137	Switch I region; other site
582899002138	G2 box; other site
582899002139	G3 box; other site
582899002140	Switch II region; other site
582899002141	G4 box; other site
582899002142	G5 box; other site
582899002143	DNA polymerase III subunit chi; Validated; Region: PRK05728
582899002144	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
582899002145	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582899002146	DNA-binding site [nucleotide binding]; DNA binding site
582899002147	RNA-binding motif; other site
582899002148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899002149	Response regulator receiver domain; Region: Response_reg; pfam00072
582899002150	active site
582899002151	phosphorylation site [posttranslational modification]
582899002152	intermolecular recognition site; other site
582899002153	dimerization interface [polypeptide binding]; other site
582899002154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
582899002155	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582899002156	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
582899002157	active site
582899002158	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
582899002159	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
582899002160	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
582899002161	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
582899002162	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899002163	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899002164	ligand binding site [chemical binding]; other site
582899002165	flexible hinge region; other site
582899002166	Hemin uptake protein hemP; Region: hemP; pfam10636
582899002167	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
582899002168	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
582899002169	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
582899002170	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
582899002171	intersubunit interface [polypeptide binding]; other site
582899002172	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
582899002173	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
582899002174	ABC-ATPase subunit  interface; other site
582899002175	dimer interface [polypeptide binding]; other site
582899002176	putative PBP binding regions; other site
582899002177	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
582899002178	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
582899002179	Walker A/P-loop; other site
582899002180	ATP binding site [chemical binding]; other site
582899002181	Q-loop/lid; other site
582899002182	ABC transporter signature motif; other site
582899002183	Walker B; other site
582899002184	D-loop; other site
582899002185	H-loop/switch region; other site
582899002186	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
582899002187	active site
582899002188	catalytic residue [active]
582899002189	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
582899002190	Predicted periplasmic protein [Function unknown]; Region: COG3904
582899002191	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
582899002192	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
582899002193	inhibitor-cofactor binding pocket; inhibition site
582899002194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002195	catalytic residue [active]
582899002196	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
582899002197	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582899002198	Cytochrome c; Region: Cytochrom_C; cl11414
582899002199	Cytochrome c; Region: Cytochrom_C; pfam00034
582899002200	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
582899002201	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
582899002202	dimer interface [polypeptide binding]; other site
582899002203	TPP-binding site [chemical binding]; other site
582899002204	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
582899002205	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
582899002206	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582899002207	E3 interaction surface; other site
582899002208	lipoyl attachment site [posttranslational modification]; other site
582899002209	e3 binding domain; Region: E3_binding; pfam02817
582899002210	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
582899002211	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
582899002212	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899002213	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899002214	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899002215	hypothetical protein; Provisional; Region: PRK10279
582899002216	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582899002217	nucleophile elbow; other site
582899002218	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
582899002219	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899002220	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
582899002221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
582899002222	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
582899002223	putative hydrophobic ligand binding site [chemical binding]; other site
582899002224	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
582899002225	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
582899002226	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
582899002227	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582899002228	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
582899002229	active site
582899002230	Int/Topo IB signature motif; other site
582899002231	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
582899002232	PLD-like domain; Region: PLDc_2; pfam13091
582899002233	putative homodimer interface [polypeptide binding]; other site
582899002234	putative active site [active]
582899002235	catalytic site [active]
582899002236	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899002237	ATP binding site [chemical binding]; other site
582899002238	putative Mg++ binding site [ion binding]; other site
582899002239	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899002240	nucleotide binding region [chemical binding]; other site
582899002241	ATP-binding site [chemical binding]; other site
582899002242	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
582899002243	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
582899002244	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
582899002245	catalytic residues [active]
582899002246	catalytic nucleophile [active]
582899002247	Presynaptic Site I dimer interface [polypeptide binding]; other site
582899002248	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
582899002249	Synaptic Flat tetramer interface [polypeptide binding]; other site
582899002250	Synaptic Site I dimer interface [polypeptide binding]; other site
582899002251	DNA binding site [nucleotide binding]
582899002252	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
582899002253	trimer interface [polypeptide binding]; other site
582899002254	eyelet of channel; other site
582899002255	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
582899002256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899002257	active site
582899002258	phosphorylation site [posttranslational modification]
582899002259	intermolecular recognition site; other site
582899002260	dimerization interface [polypeptide binding]; other site
582899002261	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899002262	DNA binding residues [nucleotide binding]
582899002263	dimerization interface [polypeptide binding]; other site
582899002264	MASE1; Region: MASE1; cl17823
582899002265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899002266	dimer interface [polypeptide binding]; other site
582899002267	phosphorylation site [posttranslational modification]
582899002268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899002269	ATP binding site [chemical binding]; other site
582899002270	Mg2+ binding site [ion binding]; other site
582899002271	G-X-G motif; other site
582899002272	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582899002273	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899002274	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582899002275	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899002276	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
582899002277	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002278	binding surface
582899002279	TPR motif; other site
582899002280	TPR repeat; Region: TPR_11; pfam13414
582899002281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002282	binding surface
582899002283	TPR repeat; Region: TPR_11; pfam13414
582899002284	TPR motif; other site
582899002285	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582899002286	active site
582899002287	metal binding site [ion binding]; metal-binding site
582899002288	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899002289	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899002290	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
582899002291	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
582899002292	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
582899002293	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
582899002294	[4Fe-4S] binding site [ion binding]; other site
582899002295	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582899002296	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582899002297	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582899002298	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
582899002299	molybdopterin cofactor binding site; other site
582899002300	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
582899002301	4Fe-4S binding domain; Region: Fer4; cl02805
582899002302	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
582899002303	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
582899002304	SurA N-terminal domain; Region: SurA_N_3; cl07813
582899002305	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
582899002306	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
582899002307	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
582899002308	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
582899002309	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
582899002310	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899002311	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899002312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582899002313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899002314	metal binding site [ion binding]; metal-binding site
582899002315	active site
582899002316	I-site; other site
582899002317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899002318	methionine sulfoxide reductase B; Provisional; Region: PRK00222
582899002319	SelR domain; Region: SelR; pfam01641
582899002320	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
582899002321	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
582899002322	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
582899002323	putative MPT binding site; other site
582899002324	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
582899002325	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
582899002326	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582899002327	GIY-YIG motif/motif A; other site
582899002328	putative active site [active]
582899002329	putative metal binding site [ion binding]; other site
582899002330	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
582899002331	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
582899002332	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
582899002333	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
582899002334	active site
582899002335	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
582899002336	TSCPD domain; Region: TSCPD; pfam12637
582899002337	NADH dehydrogenase; Validated; Region: PRK08183
582899002338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
582899002339	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
582899002340	dimer interface [polypeptide binding]; other site
582899002341	allosteric magnesium binding site [ion binding]; other site
582899002342	active site
582899002343	aspartate-rich active site metal binding site; other site
582899002344	Schiff base residues; other site
582899002345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
582899002346	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002347	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899002348	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899002349	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582899002350	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
582899002351	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
582899002352	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582899002353	substrate binding site [chemical binding]; other site
582899002354	oxyanion hole (OAH) forming residues; other site
582899002355	trimer interface [polypeptide binding]; other site
582899002356	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
582899002357	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
582899002358	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
582899002359	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
582899002360	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
582899002361	substrate-cofactor binding pocket; other site
582899002362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002363	catalytic residue [active]
582899002364	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
582899002365	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
582899002366	dimer interface [polypeptide binding]; other site
582899002367	active site
582899002368	glycine-pyridoxal phosphate binding site [chemical binding]; other site
582899002369	folate binding site [chemical binding]; other site
582899002370	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
582899002371	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
582899002372	ATP cone domain; Region: ATP-cone; pfam03477
582899002373	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
582899002374	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
582899002375	catalytic motif [active]
582899002376	Zn binding site [ion binding]; other site
582899002377	RibD C-terminal domain; Region: RibD_C; cl17279
582899002378	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
582899002379	Lumazine binding domain; Region: Lum_binding; pfam00677
582899002380	Lumazine binding domain; Region: Lum_binding; pfam00677
582899002381	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
582899002382	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
582899002383	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
582899002384	dimerization interface [polypeptide binding]; other site
582899002385	active site
582899002386	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
582899002387	homopentamer interface [polypeptide binding]; other site
582899002388	active site
582899002389	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
582899002390	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
582899002391	thiamine monophosphate kinase; Provisional; Region: PRK05731
582899002392	ATP binding site [chemical binding]; other site
582899002393	dimerization interface [polypeptide binding]; other site
582899002394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
582899002395	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002396	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899002397	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582899002398	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899002399	putative DNA binding site [nucleotide binding]; other site
582899002400	putative Zn2+ binding site [ion binding]; other site
582899002401	AsnC family; Region: AsnC_trans_reg; pfam01037
582899002402	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
582899002403	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
582899002404	hexamer interface [polypeptide binding]; other site
582899002405	ligand binding site [chemical binding]; other site
582899002406	putative active site [active]
582899002407	NAD(P) binding site [chemical binding]; other site
582899002408	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
582899002409	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582899002410	inhibitor-cofactor binding pocket; inhibition site
582899002411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002412	catalytic residue [active]
582899002413	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
582899002414	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582899002415	inhibitor-cofactor binding pocket; inhibition site
582899002416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002417	catalytic residue [active]
582899002418	succinic semialdehyde dehydrogenase; Region: PLN02278
582899002419	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
582899002420	tetramerization interface [polypeptide binding]; other site
582899002421	NAD(P) binding site [chemical binding]; other site
582899002422	catalytic residues [active]
582899002423	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582899002424	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
582899002425	NAD(P) binding site [chemical binding]; other site
582899002426	catalytic residues [active]
582899002427	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
582899002428	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582899002429	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
582899002430	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
582899002431	catalytic triad [active]
582899002432	putative aminotransferase; Validated; Region: PRK07480
582899002433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582899002434	inhibitor-cofactor binding pocket; inhibition site
582899002435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002436	catalytic residue [active]
582899002437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899002438	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
582899002439	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
582899002440	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
582899002441	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
582899002442	chaperone protein DnaJ; Provisional; Region: PRK14299
582899002443	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582899002444	HSP70 interaction site [polypeptide binding]; other site
582899002445	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
582899002446	substrate binding site [polypeptide binding]; other site
582899002447	dimer interface [polypeptide binding]; other site
582899002448	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
582899002449	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
582899002450	NTP binding site [chemical binding]; other site
582899002451	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
582899002452	nucleotide binding site [chemical binding]; other site
582899002453	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
582899002454	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
582899002455	active site
582899002456	metal binding site [ion binding]; metal-binding site
582899002457	nudix motif; other site
582899002458	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582899002459	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899002460	N-terminal plug; other site
582899002461	ligand-binding site [chemical binding]; other site
582899002462	BNR repeat-like domain; Region: BNR_2; pfam13088
582899002463	BNR repeat-like domain; Region: BNR_2; pfam13088
582899002464	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899002465	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899002466	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
582899002467	Nitronate monooxygenase; Region: NMO; pfam03060
582899002468	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
582899002469	FMN binding site [chemical binding]; other site
582899002470	substrate binding site [chemical binding]; other site
582899002471	putative catalytic residue [active]
582899002472	Predicted transcriptional regulator [Transcription]; Region: COG1959
582899002473	Transcriptional regulator; Region: Rrf2; cl17282
582899002474	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
582899002475	apolar tunnel; other site
582899002476	heme binding site [chemical binding]; other site
582899002477	dimerization interface [polypeptide binding]; other site
582899002478	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
582899002479	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582899002480	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582899002481	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
582899002482	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
582899002483	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
582899002484	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
582899002485	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
582899002486	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
582899002487	putative homodimer interface [polypeptide binding]; other site
582899002488	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
582899002489	heterodimer interface [polypeptide binding]; other site
582899002490	homodimer interface [polypeptide binding]; other site
582899002491	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
582899002492	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
582899002493	23S rRNA interface [nucleotide binding]; other site
582899002494	L7/L12 interface [polypeptide binding]; other site
582899002495	putative thiostrepton binding site; other site
582899002496	L25 interface [polypeptide binding]; other site
582899002497	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
582899002498	mRNA/rRNA interface [nucleotide binding]; other site
582899002499	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
582899002500	23S rRNA interface [nucleotide binding]; other site
582899002501	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
582899002502	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
582899002503	peripheral dimer interface [polypeptide binding]; other site
582899002504	core dimer interface [polypeptide binding]; other site
582899002505	L10 interface [polypeptide binding]; other site
582899002506	L11 interface [polypeptide binding]; other site
582899002507	putative EF-Tu interaction site [polypeptide binding]; other site
582899002508	putative EF-G interaction site [polypeptide binding]; other site
582899002509	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
582899002510	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
582899002511	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
582899002512	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582899002513	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
582899002514	RPB12 interaction site [polypeptide binding]; other site
582899002515	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582899002516	RPB1 interaction site [polypeptide binding]; other site
582899002517	RPB11 interaction site [polypeptide binding]; other site
582899002518	RPB10 interaction site [polypeptide binding]; other site
582899002519	RPB3 interaction site [polypeptide binding]; other site
582899002520	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
582899002521	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
582899002522	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
582899002523	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
582899002524	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
582899002525	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
582899002526	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
582899002527	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
582899002528	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
582899002529	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
582899002530	DNA binding site [nucleotide binding]
582899002531	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
582899002532	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
582899002533	S17 interaction site [polypeptide binding]; other site
582899002534	S8 interaction site; other site
582899002535	16S rRNA interaction site [nucleotide binding]; other site
582899002536	streptomycin interaction site [chemical binding]; other site
582899002537	23S rRNA interaction site [nucleotide binding]; other site
582899002538	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
582899002539	30S ribosomal protein S7; Validated; Region: PRK05302
582899002540	elongation factor G; Reviewed; Region: PRK00007
582899002541	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
582899002542	G1 box; other site
582899002543	putative GEF interaction site [polypeptide binding]; other site
582899002544	GTP/Mg2+ binding site [chemical binding]; other site
582899002545	Switch I region; other site
582899002546	G2 box; other site
582899002547	G3 box; other site
582899002548	Switch II region; other site
582899002549	G4 box; other site
582899002550	G5 box; other site
582899002551	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
582899002552	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
582899002553	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
582899002554	elongation factor Tu; Reviewed; Region: PRK00049
582899002555	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
582899002556	G1 box; other site
582899002557	GEF interaction site [polypeptide binding]; other site
582899002558	GTP/Mg2+ binding site [chemical binding]; other site
582899002559	Switch I region; other site
582899002560	G2 box; other site
582899002561	G3 box; other site
582899002562	Switch II region; other site
582899002563	G4 box; other site
582899002564	G5 box; other site
582899002565	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
582899002566	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
582899002567	Antibiotic Binding Site [chemical binding]; other site
582899002568	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
582899002569	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
582899002570	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
582899002571	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
582899002572	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
582899002573	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
582899002574	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
582899002575	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
582899002576	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
582899002577	putative translocon binding site; other site
582899002578	protein-rRNA interface [nucleotide binding]; other site
582899002579	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
582899002580	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
582899002581	G-X-X-G motif; other site
582899002582	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
582899002583	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
582899002584	23S rRNA interface [nucleotide binding]; other site
582899002585	5S rRNA interface [nucleotide binding]; other site
582899002586	putative antibiotic binding site [chemical binding]; other site
582899002587	L25 interface [polypeptide binding]; other site
582899002588	L27 interface [polypeptide binding]; other site
582899002589	50S ribosomal protein L29; Reviewed; Region: PRK00306
582899002590	putative translocon interaction site; other site
582899002591	23S rRNA interface [nucleotide binding]; other site
582899002592	signal recognition particle (SRP54) interaction site; other site
582899002593	L23 interface [polypeptide binding]; other site
582899002594	trigger factor interaction site; other site
582899002595	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
582899002596	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
582899002597	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
582899002598	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
582899002599	RNA binding site [nucleotide binding]; other site
582899002600	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
582899002601	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
582899002602	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
582899002603	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
582899002604	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
582899002605	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
582899002606	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582899002607	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582899002608	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
582899002609	23S rRNA interface [nucleotide binding]; other site
582899002610	L21e interface [polypeptide binding]; other site
582899002611	5S rRNA interface [nucleotide binding]; other site
582899002612	L27 interface [polypeptide binding]; other site
582899002613	L5 interface [polypeptide binding]; other site
582899002614	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
582899002615	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
582899002616	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
582899002617	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
582899002618	23S rRNA binding site [nucleotide binding]; other site
582899002619	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
582899002620	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
582899002621	SecY translocase; Region: SecY; pfam00344
582899002622	adenylate kinase; Reviewed; Region: adk; PRK00279
582899002623	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
582899002624	AMP-binding site [chemical binding]; other site
582899002625	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
582899002626	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
582899002627	30S ribosomal protein S13; Region: bact_S13; TIGR03631
582899002628	30S ribosomal protein S11; Validated; Region: PRK05309
582899002629	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
582899002630	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
582899002631	alphaNTD - beta interaction site [polypeptide binding]; other site
582899002632	alphaNTD homodimer interface [polypeptide binding]; other site
582899002633	alphaNTD - beta' interaction site [polypeptide binding]; other site
582899002634	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
582899002635	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
582899002636	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
582899002637	dihydroflavonol-4-reductase; Region: PLN02650
582899002638	NADP binding site [chemical binding]; other site
582899002639	putative substrate binding site [chemical binding]; other site
582899002640	active site
582899002641	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582899002642	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582899002643	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899002644	protein binding site [polypeptide binding]; other site
582899002645	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899002646	protein binding site [polypeptide binding]; other site
582899002647	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582899002648	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
582899002649	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
582899002650	G1 box; other site
582899002651	putative GEF interaction site [polypeptide binding]; other site
582899002652	GTP/Mg2+ binding site [chemical binding]; other site
582899002653	Switch I region; other site
582899002654	G2 box; other site
582899002655	CysD dimerization site [polypeptide binding]; other site
582899002656	G3 box; other site
582899002657	Switch II region; other site
582899002658	G4 box; other site
582899002659	G5 box; other site
582899002660	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
582899002661	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
582899002662	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
582899002663	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
582899002664	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582899002665	Active Sites [active]
582899002666	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
582899002667	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582899002668	Active Sites [active]
582899002669	hypothetical protein; Provisional; Region: PRK07236
582899002670	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
582899002671	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582899002672	DNA-binding site [nucleotide binding]; DNA binding site
582899002673	RNA-binding motif; other site
582899002674	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582899002675	DNA-binding site [nucleotide binding]; DNA binding site
582899002676	RNA-binding motif; other site
582899002677	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
582899002678	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
582899002679	Cytochrome c; Region: Cytochrom_C; pfam00034
582899002680	Cytochrome c; Region: Cytochrom_C; pfam00034
582899002681	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
582899002682	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
582899002683	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
582899002684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899002685	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
582899002686	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
582899002687	putative uracil binding site [chemical binding]; other site
582899002688	putative active site [active]
582899002689	Uncharacterized conserved protein [Function unknown]; Region: COG3189
582899002690	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
582899002691	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
582899002692	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
582899002693	ethanolamine permease; Region: 2A0305; TIGR00908
582899002694	transcriptional regulator EutR; Provisional; Region: PRK10130
582899002695	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582899002696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899002697	putative active site [active]
582899002698	heme pocket [chemical binding]; other site
582899002699	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582899002700	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899002701	metal binding site [ion binding]; metal-binding site
582899002702	active site
582899002703	I-site; other site
582899002704	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899002705	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
582899002706	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
582899002707	putative DNA binding site [nucleotide binding]; other site
582899002708	putative homodimer interface [polypeptide binding]; other site
582899002709	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
582899002710	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
582899002711	active site
582899002712	DNA binding site [nucleotide binding]
582899002713	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
582899002714	DNA binding site [nucleotide binding]
582899002715	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
582899002716	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
582899002717	nucleotide binding site [chemical binding]; other site
582899002718	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
582899002719	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
582899002720	PRC-barrel domain; Region: PRC; pfam05239
582899002721	short chain dehydrogenase; Provisional; Region: PRK06701
582899002722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899002723	NAD(P) binding site [chemical binding]; other site
582899002724	active site
582899002725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
582899002726	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002727	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899002728	cystathionine beta-lyase; Provisional; Region: PRK05967
582899002729	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582899002730	homodimer interface [polypeptide binding]; other site
582899002731	substrate-cofactor binding pocket; other site
582899002732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899002733	catalytic residue [active]
582899002734	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899002735	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
582899002736	substrate binding pocket [chemical binding]; other site
582899002737	membrane-bound complex binding site; other site
582899002738	hinge residues; other site
582899002739	von Willebrand factor type A domain; Region: VWA_2; pfam13519
582899002740	metal ion-dependent adhesion site (MIDAS); other site
582899002741	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
582899002742	putative FMN binding site [chemical binding]; other site
582899002743	ATP-NAD kinase; Region: NAD_kinase; pfam01513
582899002744	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
582899002745	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
582899002746	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
582899002747	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582899002748	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
582899002749	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
582899002750	DnaA box-binding interface [nucleotide binding]; other site
582899002751	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
582899002752	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002753	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002754	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
582899002755	Predicted integral membrane protein [Function unknown]; Region: COG5436
582899002756	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
582899002757	Transglycosylase; Region: Transgly; pfam00912
582899002758	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
582899002759	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
582899002760	hypothetical protein; Provisional; Region: PRK05170
582899002761	Uncharacterized conserved protein [Function unknown]; Region: COG5323
582899002762	Terminase-like family; Region: Terminase_6; pfam03237
582899002763	Phage-related protein [Function unknown]; Region: COG4695
582899002764	Phage portal protein; Region: Phage_portal; pfam04860
582899002765	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
582899002766	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
582899002767	Phage capsid family; Region: Phage_capsid; pfam05065
582899002768	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
582899002769	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
582899002770	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
582899002771	oligomerization interface [polypeptide binding]; other site
582899002772	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
582899002773	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
582899002774	Phage major tail protein 2; Region: Phage_tail_2; cl11463
582899002775	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
582899002776	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
582899002777	Phage-related minor tail protein [Function unknown]; Region: COG5281
582899002778	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
582899002779	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
582899002780	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
582899002781	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
582899002782	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
582899002783	NlpC/P60 family; Region: NLPC_P60; cl17555
582899002784	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
582899002785	Putative phage tail protein; Region: Phage-tail_3; pfam13550
582899002786	TIGR02594 family protein; Region: TIGR02594
582899002787	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
582899002788	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
582899002789	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899002790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899002791	active site
582899002792	phosphorylation site [posttranslational modification]
582899002793	intermolecular recognition site; other site
582899002794	dimerization interface [polypeptide binding]; other site
582899002795	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899002796	DNA binding site [nucleotide binding]
582899002797	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
582899002798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899002799	ATP binding site [chemical binding]; other site
582899002800	Mg2+ binding site [ion binding]; other site
582899002801	G-X-G motif; other site
582899002802	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
582899002803	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
582899002804	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
582899002805	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
582899002806	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
582899002807	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
582899002808	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582899002809	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
582899002810	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899002811	protein binding site [polypeptide binding]; other site
582899002812	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
582899002813	protein binding site [polypeptide binding]; other site
582899002814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899002815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899002816	active site
582899002817	phosphorylation site [posttranslational modification]
582899002818	intermolecular recognition site; other site
582899002819	dimerization interface [polypeptide binding]; other site
582899002820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899002821	DNA binding site [nucleotide binding]
582899002822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899002823	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899002824	dimerization interface [polypeptide binding]; other site
582899002825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899002826	dimer interface [polypeptide binding]; other site
582899002827	phosphorylation site [posttranslational modification]
582899002828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899002829	ATP binding site [chemical binding]; other site
582899002830	Mg2+ binding site [ion binding]; other site
582899002831	G-X-G motif; other site
582899002832	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
582899002833	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582899002834	metal binding triad; other site
582899002835	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582899002836	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582899002837	metal binding triad; other site
582899002838	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582899002839	RNA polymerase sigma factor; Reviewed; Region: PRK05602
582899002840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899002841	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899002842	DNA binding residues [nucleotide binding]
582899002843	Heavy-metal resistance; Region: Metal_resist; pfam13801
582899002844	dimer interface [polypeptide binding]; other site
582899002845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899002846	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899002847	dimer interface [polypeptide binding]; other site
582899002848	phosphorylation site [posttranslational modification]
582899002849	aminopeptidase N; Provisional; Region: pepN; PRK14015
582899002850	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
582899002851	active site
582899002852	Zn binding site [ion binding]; other site
582899002853	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
582899002854	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
582899002855	dimer interface [polypeptide binding]; other site
582899002856	active site
582899002857	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582899002858	catalytic residues [active]
582899002859	substrate binding site [chemical binding]; other site
582899002860	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
582899002861	Cytochrome c; Region: Cytochrom_C; pfam00034
582899002862	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
582899002863	Moco binding site; other site
582899002864	metal coordination site [ion binding]; other site
582899002865	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
582899002866	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582899002867	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899002868	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899002869	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899002870	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899002871	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899002872	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582899002873	TPR repeat; Region: TPR_11; pfam13414
582899002874	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002875	binding surface
582899002876	TPR motif; other site
582899002877	TPR repeat; Region: TPR_11; pfam13414
582899002878	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002879	TPR motif; other site
582899002880	binding surface
582899002881	TPR repeat; Region: TPR_11; pfam13414
582899002882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899002883	binding surface
582899002884	TPR motif; other site
582899002885	TPR repeat; Region: TPR_11; pfam13414
582899002886	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582899002887	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
582899002888	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
582899002889	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
582899002890	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899002891	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582899002892	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899002893	putative DNA binding site [nucleotide binding]; other site
582899002894	putative Zn2+ binding site [ion binding]; other site
582899002895	Predicted dehydrogenase [General function prediction only]; Region: COG0579
582899002896	hydroxyglutarate oxidase; Provisional; Region: PRK11728
582899002897	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582899002898	active site
582899002899	Int/Topo IB signature motif; other site
582899002900	DNA binding site [nucleotide binding]
582899002901	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
582899002902	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
582899002903	Ligand Binding Site [chemical binding]; other site
582899002904	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
582899002905	non-specific DNA binding site [nucleotide binding]; other site
582899002906	salt bridge; other site
582899002907	sequence-specific DNA binding site [nucleotide binding]; other site
582899002908	DnaA N-terminal domain; Region: DnaA_N; pfam11638
582899002909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582899002910	ATP binding site [chemical binding]; other site
582899002911	putative Mg++ binding site [ion binding]; other site
582899002912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
582899002913	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
582899002914	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
582899002915	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542
582899002916	metal binding site [ion binding]; metal-binding site
582899002917	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899002918	non-specific DNA binding site [nucleotide binding]; other site
582899002919	salt bridge; other site
582899002920	sequence-specific DNA binding site [nucleotide binding]; other site
582899002921	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
582899002922	Glutamine amidotransferases class-II; Region: GATase_4; pfam13230
582899002923	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899002924	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
582899002925	gpW; Region: gpW; pfam02831
582899002926	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
582899002927	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
582899002928	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
582899002929	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
582899002930	tandem repeat interface [polypeptide binding]; other site
582899002931	oligomer interface [polypeptide binding]; other site
582899002932	active site residues [active]
582899002933	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
582899002934	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
582899002935	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
582899002936	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
582899002937	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
582899002938	Phage tail tube protein; Region: Tail_tube; pfam10618
582899002939	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
582899002940	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
582899002941	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
582899002942	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
582899002943	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
582899002944	PAAR motif; Region: PAAR_motif; pfam05488
582899002945	Phage protein GP46; Region: GP46; pfam07409
582899002946	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
582899002947	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
582899002948	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
582899002949	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
582899002950	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
582899002951	hypothetical protein; Provisional; Region: PRK11281
582899002952	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
582899002953	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582899002954	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
582899002955	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
582899002956	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
582899002957	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582899002958	HIGH motif; other site
582899002959	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
582899002960	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582899002961	active site
582899002962	KMSKS motif; other site
582899002963	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
582899002964	tRNA binding surface [nucleotide binding]; other site
582899002965	anticodon binding site; other site
582899002966	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
582899002967	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
582899002968	Peptidase family M48; Region: Peptidase_M48; cl12018
582899002969	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
582899002970	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582899002971	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
582899002972	putative catalytic site [active]
582899002973	putative phosphate binding site [ion binding]; other site
582899002974	active site
582899002975	metal binding site A [ion binding]; metal-binding site
582899002976	DNA binding site [nucleotide binding]
582899002977	putative AP binding site [nucleotide binding]; other site
582899002978	putative metal binding site B [ion binding]; other site
582899002979	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
582899002980	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
582899002981	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582899002982	Zn2+ binding site [ion binding]; other site
582899002983	Mg2+ binding site [ion binding]; other site
582899002984	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
582899002985	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
582899002986	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
582899002987	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
582899002988	active site
582899002989	HIGH motif; other site
582899002990	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899002991	KMSK motif region; other site
582899002992	tRNA binding surface [nucleotide binding]; other site
582899002993	DALR anticodon binding domain; Region: DALR_1; smart00836
582899002994	anticodon binding site; other site
582899002995	Sporulation related domain; Region: SPOR; pfam05036
582899002996	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
582899002997	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
582899002998	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
582899002999	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
582899003000	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
582899003001	seryl-tRNA synthetase; Provisional; Region: PRK05431
582899003002	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
582899003003	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
582899003004	dimer interface [polypeptide binding]; other site
582899003005	active site
582899003006	motif 1; other site
582899003007	motif 2; other site
582899003008	motif 3; other site
582899003009	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
582899003010	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
582899003011	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582899003012	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
582899003013	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582899003014	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582899003015	Peptidase family M23; Region: Peptidase_M23; pfam01551
582899003016	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
582899003017	Protein of unknown function (DUF815); Region: DUF815; pfam05673
582899003018	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
582899003019	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
582899003020	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
582899003021	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
582899003022	Protein export membrane protein; Region: SecD_SecF; pfam02355
582899003023	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
582899003024	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
582899003025	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
582899003026	active site
582899003027	catalytic triad [active]
582899003028	oxyanion hole [active]
582899003029	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
582899003030	Glucose inhibited division protein A; Region: GIDA; pfam01134
582899003031	manganese transport protein MntH; Reviewed; Region: PRK00701
582899003032	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
582899003033	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
582899003034	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
582899003035	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
582899003036	homotrimer interaction site [polypeptide binding]; other site
582899003037	putative active site [active]
582899003038	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
582899003039	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
582899003040	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
582899003041	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
582899003042	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
582899003043	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
582899003044	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
582899003045	putative phosphate acyltransferase; Provisional; Region: PRK05331
582899003046	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
582899003047	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582899003048	dimer interface [polypeptide binding]; other site
582899003049	active site
582899003050	CoA binding pocket [chemical binding]; other site
582899003051	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582899003052	IHF dimer interface [polypeptide binding]; other site
582899003053	IHF - DNA interface [nucleotide binding]; other site
582899003054	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
582899003055	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
582899003056	DNA binding residues [nucleotide binding]
582899003057	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
582899003058	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
582899003059	Amino acid permease; Region: AA_permease_2; pfam13520
582899003060	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
582899003061	lipoyl attachment site [posttranslational modification]; other site
582899003062	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
582899003063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899003064	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899003065	OsmC-like protein; Region: OsmC; pfam02566
582899003066	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
582899003067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003068	active site
582899003069	phosphorylation site [posttranslational modification]
582899003070	intermolecular recognition site; other site
582899003071	dimerization interface [polypeptide binding]; other site
582899003072	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899003073	DNA binding residues [nucleotide binding]
582899003074	dimerization interface [polypeptide binding]; other site
582899003075	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582899003076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899003077	putative active site [active]
582899003078	heme pocket [chemical binding]; other site
582899003079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899003080	dimer interface [polypeptide binding]; other site
582899003081	phosphorylation site [posttranslational modification]
582899003082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003083	ATP binding site [chemical binding]; other site
582899003084	Mg2+ binding site [ion binding]; other site
582899003085	G-X-G motif; other site
582899003086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899003087	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899003088	putative substrate translocation pore; other site
582899003089	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899003090	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
582899003091	Trp docking motif [polypeptide binding]; other site
582899003092	dimer interface [polypeptide binding]; other site
582899003093	active site
582899003094	small subunit binding site [polypeptide binding]; other site
582899003095	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899003096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003097	active site
582899003098	phosphorylation site [posttranslational modification]
582899003099	intermolecular recognition site; other site
582899003100	dimerization interface [polypeptide binding]; other site
582899003101	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899003102	DNA binding residues [nucleotide binding]
582899003103	dimerization interface [polypeptide binding]; other site
582899003104	TraB family; Region: TraB; cl12050
582899003105	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582899003106	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003107	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003108	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003109	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582899003110	putative hydrophobic ligand binding site [chemical binding]; other site
582899003111	protein interface [polypeptide binding]; other site
582899003112	gate; other site
582899003113	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582899003114	metal ion-dependent adhesion site (MIDAS); other site
582899003115	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582899003116	metal ion-dependent adhesion site (MIDAS); other site
582899003117	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582899003118	metal ion-dependent adhesion site (MIDAS); other site
582899003119	MoxR-like ATPases [General function prediction only]; Region: COG0714
582899003120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899003121	Walker A motif; other site
582899003122	ATP binding site [chemical binding]; other site
582899003123	Walker B motif; other site
582899003124	arginine finger; other site
582899003125	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
582899003126	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
582899003127	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
582899003128	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899003129	substrate binding pocket [chemical binding]; other site
582899003130	membrane-bound complex binding site; other site
582899003131	hinge residues; other site
582899003132	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899003133	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
582899003134	Trp docking motif [polypeptide binding]; other site
582899003135	dimer interface [polypeptide binding]; other site
582899003136	active site
582899003137	small subunit binding site [polypeptide binding]; other site
582899003138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
582899003139	HAMP domain; Region: HAMP; pfam00672
582899003140	dimerization interface [polypeptide binding]; other site
582899003141	Histidine kinase; Region: HisKA_3; pfam07730
582899003142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003143	ATP binding site [chemical binding]; other site
582899003144	Mg2+ binding site [ion binding]; other site
582899003145	G-X-G motif; other site
582899003146	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899003147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003148	active site
582899003149	phosphorylation site [posttranslational modification]
582899003150	intermolecular recognition site; other site
582899003151	dimerization interface [polypeptide binding]; other site
582899003152	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899003153	DNA binding residues [nucleotide binding]
582899003154	dimerization interface [polypeptide binding]; other site
582899003155	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
582899003156	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
582899003157	Ca2+ binding site [ion binding]; other site
582899003158	Helix-turn-helix domain; Region: HTH_18; pfam12833
582899003159	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
582899003160	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899003161	N-terminal plug; other site
582899003162	ligand-binding site [chemical binding]; other site
582899003163	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582899003164	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
582899003165	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
582899003166	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
582899003167	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899003168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
582899003169	S-adenosylmethionine binding site [chemical binding]; other site
582899003170	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
582899003171	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899003172	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582899003173	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899003174	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
582899003175	Cupin-like domain; Region: Cupin_8; pfam13621
582899003176	Condensation domain; Region: Condensation; pfam00668
582899003177	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
582899003178	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
582899003179	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
582899003180	acyl-activating enzyme (AAE) consensus motif; other site
582899003181	AMP binding site [chemical binding]; other site
582899003182	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
582899003183	Condensation domain; Region: Condensation; pfam00668
582899003184	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
582899003185	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
582899003186	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
582899003187	acyl-activating enzyme (AAE) consensus motif; other site
582899003188	AMP binding site [chemical binding]; other site
582899003189	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
582899003190	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
582899003191	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
582899003192	active site
582899003193	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
582899003194	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
582899003195	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
582899003196	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
582899003197	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582899003198	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899003199	catalytic residue [active]
582899003200	Condensation domain; Region: Condensation; pfam00668
582899003201	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
582899003202	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
582899003203	acyl-activating enzyme (AAE) consensus motif; other site
582899003204	AMP binding site [chemical binding]; other site
582899003205	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
582899003206	Condensation domain; Region: Condensation; pfam00668
582899003207	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
582899003208	Condensation domain; Region: Condensation; pfam00668
582899003209	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
582899003210	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
582899003211	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
582899003212	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
582899003213	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
582899003214	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
582899003215	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582899003216	active site
582899003217	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
582899003218	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
582899003219	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
582899003220	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582899003221	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582899003222	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
582899003223	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
582899003224	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899003225	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
582899003226	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582899003227	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
582899003228	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
582899003229	active site
582899003230	dimer interface [polypeptide binding]; other site
582899003231	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
582899003232	Ligand Binding Site [chemical binding]; other site
582899003233	Molecular Tunnel; other site
582899003234	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
582899003235	Bacterial sugar transferase; Region: Bac_transf; pfam02397
582899003236	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
582899003237	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
582899003238	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
582899003239	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
582899003240	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
582899003241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
582899003242	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
582899003243	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
582899003244	active site
582899003245	homotetramer interface [polypeptide binding]; other site
582899003246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899003247	HWE histidine kinase; Region: HWE_HK; smart00911
582899003248	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
582899003249	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
582899003250	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003252	active site
582899003253	phosphorylation site [posttranslational modification]
582899003254	intermolecular recognition site; other site
582899003255	dimerization interface [polypeptide binding]; other site
582899003256	PAS fold; Region: PAS_3; pfam08447
582899003257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899003258	heme pocket [chemical binding]; other site
582899003259	putative active site [active]
582899003260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899003261	HWE histidine kinase; Region: HWE_HK; smart00911
582899003262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003263	active site
582899003264	phosphorylation site [posttranslational modification]
582899003265	intermolecular recognition site; other site
582899003266	dimerization interface [polypeptide binding]; other site
582899003267	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582899003268	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003269	dimerization interface [polypeptide binding]; other site
582899003270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003271	dimerization interface [polypeptide binding]; other site
582899003272	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003273	dimerization interface [polypeptide binding]; other site
582899003274	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582899003275	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003276	dimerization interface [polypeptide binding]; other site
582899003277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003278	dimerization interface [polypeptide binding]; other site
582899003279	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003280	dimerization interface [polypeptide binding]; other site
582899003281	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003282	dimerization interface [polypeptide binding]; other site
582899003283	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003284	dimerization interface [polypeptide binding]; other site
582899003285	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003286	dimerization interface [polypeptide binding]; other site
582899003287	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582899003288	GAF domain; Region: GAF; pfam01590
582899003289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899003290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899003291	dimer interface [polypeptide binding]; other site
582899003292	phosphorylation site [posttranslational modification]
582899003293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003294	ATP binding site [chemical binding]; other site
582899003295	Mg2+ binding site [ion binding]; other site
582899003296	G-X-G motif; other site
582899003297	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003299	active site
582899003300	phosphorylation site [posttranslational modification]
582899003301	intermolecular recognition site; other site
582899003302	dimerization interface [polypeptide binding]; other site
582899003303	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003305	active site
582899003306	phosphorylation site [posttranslational modification]
582899003307	intermolecular recognition site; other site
582899003308	dimerization interface [polypeptide binding]; other site
582899003309	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003311	active site
582899003312	phosphorylation site [posttranslational modification]
582899003313	intermolecular recognition site; other site
582899003314	dimerization interface [polypeptide binding]; other site
582899003315	RNA polymerase sigma factor; Provisional; Region: PRK12547
582899003316	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899003317	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899003318	DNA binding residues [nucleotide binding]
582899003319	two-component response regulator; Provisional; Region: PRK09191
582899003320	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
582899003321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003322	active site
582899003323	phosphorylation site [posttranslational modification]
582899003324	intermolecular recognition site; other site
582899003325	dimerization interface [polypeptide binding]; other site
582899003326	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
582899003327	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
582899003328	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
582899003329	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899003330	putative ADP-binding pocket [chemical binding]; other site
582899003331	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582899003332	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582899003333	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
582899003334	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
582899003335	E-class dimer interface [polypeptide binding]; other site
582899003336	P-class dimer interface [polypeptide binding]; other site
582899003337	active site
582899003338	Cu2+ binding site [ion binding]; other site
582899003339	Zn2+ binding site [ion binding]; other site
582899003340	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
582899003341	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582899003342	putative hydrophobic ligand binding site [chemical binding]; other site
582899003343	protein interface [polypeptide binding]; other site
582899003344	gate; other site
582899003345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899003346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003347	active site
582899003348	phosphorylation site [posttranslational modification]
582899003349	intermolecular recognition site; other site
582899003350	dimerization interface [polypeptide binding]; other site
582899003351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899003352	DNA binding residues [nucleotide binding]
582899003353	dimerization interface [polypeptide binding]; other site
582899003354	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899003355	dimerization interface [polypeptide binding]; other site
582899003356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
582899003357	Histidine kinase; Region: HisKA_3; pfam07730
582899003358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003359	ATP binding site [chemical binding]; other site
582899003360	Mg2+ binding site [ion binding]; other site
582899003361	G-X-G motif; other site
582899003362	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
582899003363	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
582899003364	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
582899003365	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899003366	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582899003367	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582899003368	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
582899003369	SLBB domain; Region: SLBB; pfam10531
582899003370	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
582899003371	Chain length determinant protein; Region: Wzz; pfam02706
582899003372	AAA domain; Region: AAA_31; pfam13614
582899003373	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582899003374	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
582899003375	putative active site [active]
582899003376	putative metal binding site [ion binding]; other site
582899003377	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
582899003378	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
582899003379	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
582899003380	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
582899003381	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
582899003382	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
582899003383	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
582899003384	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
582899003385	23S rRNA interface [nucleotide binding]; other site
582899003386	L3 interface [polypeptide binding]; other site
582899003387	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
582899003388	active site
582899003389	enoyl-CoA hydratase; Validated; Region: PRK08139
582899003390	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582899003391	substrate binding site [chemical binding]; other site
582899003392	oxyanion hole (OAH) forming residues; other site
582899003393	trimer interface [polypeptide binding]; other site
582899003394	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
582899003395	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899003396	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
582899003397	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
582899003398	dimerization interface [polypeptide binding]; other site
582899003399	active site
582899003400	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
582899003401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899003402	Coenzyme A binding pocket [chemical binding]; other site
582899003403	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
582899003404	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
582899003405	active site
582899003406	catalytic residues [active]
582899003407	metal binding site [ion binding]; metal-binding site
582899003408	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
582899003409	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582899003410	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
582899003411	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
582899003412	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
582899003413	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
582899003414	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
582899003415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582899003416	active site
582899003417	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
582899003418	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
582899003419	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582899003420	substrate binding site [chemical binding]; other site
582899003421	oxyanion hole (OAH) forming residues; other site
582899003422	trimer interface [polypeptide binding]; other site
582899003423	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
582899003424	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
582899003425	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
582899003426	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
582899003427	dimer interface [polypeptide binding]; other site
582899003428	active site
582899003429	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
582899003430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899003431	S-adenosylmethionine binding site [chemical binding]; other site
582899003432	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
582899003433	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582899003434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899003435	Walker A/P-loop; other site
582899003436	ATP binding site [chemical binding]; other site
582899003437	Q-loop/lid; other site
582899003438	ABC transporter signature motif; other site
582899003439	Walker B; other site
582899003440	D-loop; other site
582899003441	H-loop/switch region; other site
582899003442	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
582899003443	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
582899003444	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899003445	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582899003446	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
582899003447	active site
582899003448	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
582899003449	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
582899003450	putative NAD(P) binding site [chemical binding]; other site
582899003451	glucosyltransferase MdoH; Provisional; Region: PRK05454
582899003452	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
582899003453	active site
582899003454	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
582899003455	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
582899003456	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
582899003457	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899003458	motif II; other site
582899003459	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
582899003460	folate binding site [chemical binding]; other site
582899003461	NADP+ binding site [chemical binding]; other site
582899003462	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
582899003463	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
582899003464	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
582899003465	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
582899003466	NAD(P) binding site [chemical binding]; other site
582899003467	catalytic residues [active]
582899003468	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003470	active site
582899003471	phosphorylation site [posttranslational modification]
582899003472	intermolecular recognition site; other site
582899003473	dimerization interface [polypeptide binding]; other site
582899003474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899003475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899003476	dimer interface [polypeptide binding]; other site
582899003477	phosphorylation site [posttranslational modification]
582899003478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003479	ATP binding site [chemical binding]; other site
582899003480	Mg2+ binding site [ion binding]; other site
582899003481	G-X-G motif; other site
582899003482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003483	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003484	active site
582899003485	phosphorylation site [posttranslational modification]
582899003486	intermolecular recognition site; other site
582899003487	dimerization interface [polypeptide binding]; other site
582899003488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899003489	dimer interface [polypeptide binding]; other site
582899003490	phosphorylation site [posttranslational modification]
582899003491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899003492	ATP binding site [chemical binding]; other site
582899003493	Mg2+ binding site [ion binding]; other site
582899003494	G-X-G motif; other site
582899003495	Methyltransferase domain; Region: Methyltransf_25; pfam13649
582899003496	Response regulator receiver domain; Region: Response_reg; pfam00072
582899003497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899003498	active site
582899003499	phosphorylation site [posttranslational modification]
582899003500	intermolecular recognition site; other site
582899003501	dimerization interface [polypeptide binding]; other site
582899003502	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
582899003503	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
582899003504	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582899003505	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
582899003506	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
582899003507	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
582899003508	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
582899003509	Walker A/P-loop; other site
582899003510	ATP binding site [chemical binding]; other site
582899003511	Q-loop/lid; other site
582899003512	ABC transporter signature motif; other site
582899003513	Walker B; other site
582899003514	D-loop; other site
582899003515	H-loop/switch region; other site
582899003516	TOBE domain; Region: TOBE_2; pfam08402
582899003517	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
582899003518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899003519	dimer interface [polypeptide binding]; other site
582899003520	conserved gate region; other site
582899003521	putative PBP binding loops; other site
582899003522	ABC-ATPase subunit interface; other site
582899003523	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
582899003524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899003525	dimer interface [polypeptide binding]; other site
582899003526	conserved gate region; other site
582899003527	putative PBP binding loops; other site
582899003528	ABC-ATPase subunit interface; other site
582899003529	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
582899003530	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
582899003531	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
582899003532	RNA polymerase sigma factor; Provisional; Region: PRK12512
582899003533	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899003534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899003535	DNA binding residues [nucleotide binding]
582899003536	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
582899003537	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
582899003538	putative [4Fe-4S] binding site [ion binding]; other site
582899003539	putative molybdopterin cofactor binding site [chemical binding]; other site
582899003540	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
582899003541	putative molybdopterin cofactor binding site; other site
582899003542	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
582899003543	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899003544	FeS/SAM binding site; other site
582899003545	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
582899003546	Uncharacterized conserved protein [Function unknown]; Region: COG3791
582899003547	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582899003548	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
582899003549	motif 1; other site
582899003550	dimer interface [polypeptide binding]; other site
582899003551	active site
582899003552	motif 2; other site
582899003553	motif 3; other site
582899003554	elongation factor P; Validated; Region: PRK00529
582899003555	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
582899003556	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
582899003557	RNA binding site [nucleotide binding]; other site
582899003558	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
582899003559	RNA binding site [nucleotide binding]; other site
582899003560	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
582899003561	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
582899003562	dimer interface [polypeptide binding]; other site
582899003563	putative functional site; other site
582899003564	putative MPT binding site; other site
582899003565	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
582899003566	trimer interface [polypeptide binding]; other site
582899003567	dimer interface [polypeptide binding]; other site
582899003568	putative active site [active]
582899003569	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
582899003570	active site
582899003571	ribulose/triose binding site [chemical binding]; other site
582899003572	phosphate binding site [ion binding]; other site
582899003573	substrate (anthranilate) binding pocket [chemical binding]; other site
582899003574	product (indole) binding pocket [chemical binding]; other site
582899003575	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
582899003576	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
582899003577	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
582899003578	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
582899003579	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
582899003580	glutamine binding [chemical binding]; other site
582899003581	catalytic triad [active]
582899003582	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582899003583	catalytic core [active]
582899003584	anthranilate synthase component I; Provisional; Region: PRK13573
582899003585	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582899003586	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
582899003587	SurA N-terminal domain; Region: SurA_N_3; cl07813
582899003588	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
582899003589	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
582899003590	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
582899003591	triosephosphate isomerase; Provisional; Region: PRK14565
582899003592	substrate binding site [chemical binding]; other site
582899003593	dimer interface [polypeptide binding]; other site
582899003594	catalytic triad [active]
582899003595	CTP synthetase; Validated; Region: pyrG; PRK05380
582899003596	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
582899003597	Catalytic site [active]
582899003598	active site
582899003599	UTP binding site [chemical binding]; other site
582899003600	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
582899003601	active site
582899003602	putative oxyanion hole; other site
582899003603	catalytic triad [active]
582899003604	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
582899003605	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
582899003606	ABC-2 type transporter; Region: ABC2_membrane; cl17235
582899003607	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
582899003608	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899003609	Walker A/P-loop; other site
582899003610	ATP binding site [chemical binding]; other site
582899003611	Q-loop/lid; other site
582899003612	ABC transporter signature motif; other site
582899003613	Walker B; other site
582899003614	D-loop; other site
582899003615	H-loop/switch region; other site
582899003616	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582899003617	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003618	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003619	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003620	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
582899003621	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899003622	ligand binding site [chemical binding]; other site
582899003623	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
582899003624	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899003625	substrate binding pocket [chemical binding]; other site
582899003626	membrane-bound complex binding site; other site
582899003627	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
582899003628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899003629	dimer interface [polypeptide binding]; other site
582899003630	conserved gate region; other site
582899003631	putative PBP binding loops; other site
582899003632	ABC-ATPase subunit interface; other site
582899003633	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
582899003634	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
582899003635	Walker A/P-loop; other site
582899003636	ATP binding site [chemical binding]; other site
582899003637	Q-loop/lid; other site
582899003638	ABC transporter signature motif; other site
582899003639	Walker B; other site
582899003640	D-loop; other site
582899003641	H-loop/switch region; other site
582899003642	hypothetical protein; Provisional; Region: PRK02227
582899003643	Dihydroneopterin aldolase; Region: FolB; pfam02152
582899003644	active site
582899003645	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
582899003646	nucleotide binding site [chemical binding]; other site
582899003647	substrate binding site [chemical binding]; other site
582899003648	Protein of unknown function (DUF447); Region: DUF447; pfam04289
582899003649	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582899003650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899003651	S-adenosylmethionine binding site [chemical binding]; other site
582899003652	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
582899003653	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
582899003654	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
582899003655	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
582899003656	active site
582899003657	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
582899003658	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
582899003659	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
582899003660	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582899003661	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
582899003662	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
582899003663	trimer interface I [polypeptide binding]; other site
582899003664	putative substrate binding pocket [chemical binding]; other site
582899003665	trimer interface II [polypeptide binding]; other site
582899003666	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
582899003667	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582899003668	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
582899003669	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
582899003670	NAD(P) binding pocket [chemical binding]; other site
582899003671	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
582899003672	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
582899003673	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
582899003674	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
582899003675	aromatic arch; other site
582899003676	DCoH dimer interaction site [polypeptide binding]; other site
582899003677	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
582899003678	DCoH tetramer interaction site [polypeptide binding]; other site
582899003679	substrate binding site [chemical binding]; other site
582899003680	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
582899003681	catalytic center binding site [active]
582899003682	ATP binding site [chemical binding]; other site
582899003683	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582899003684	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
582899003685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899003686	FeS/SAM binding site; other site
582899003687	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
582899003688	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
582899003689	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
582899003690	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
582899003691	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
582899003692	PqqA family; Region: PqqA; cl15372
582899003693	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
582899003694	Flavodoxin; Region: Flavodoxin_1; pfam00258
582899003695	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
582899003696	FAD binding pocket [chemical binding]; other site
582899003697	FAD binding motif [chemical binding]; other site
582899003698	catalytic residues [active]
582899003699	NAD binding pocket [chemical binding]; other site
582899003700	phosphate binding motif [ion binding]; other site
582899003701	beta-alpha-beta structure motif; other site
582899003702	sulfite reductase subunit beta; Provisional; Region: PRK13504
582899003703	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582899003704	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582899003705	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
582899003706	recombination factor protein RarA; Reviewed; Region: PRK13342
582899003707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899003708	Walker A motif; other site
582899003709	ATP binding site [chemical binding]; other site
582899003710	Walker B motif; other site
582899003711	arginine finger; other site
582899003712	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
582899003713	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582899003714	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582899003715	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
582899003716	RNA binding surface [nucleotide binding]; other site
582899003717	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582899003718	active site
582899003719	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582899003720	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899003721	motif II; other site
582899003722	ATP12 chaperone protein; Region: ATP12; cl02228
582899003723	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
582899003724	Domain of unknown function DUF21; Region: DUF21; pfam01595
582899003725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582899003726	Transporter associated domain; Region: CorC_HlyC; smart01091
582899003727	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
582899003728	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
582899003729	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
582899003730	BNR repeat-like domain; Region: BNR_2; pfam13088
582899003731	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899003732	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
582899003733	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
582899003734	MgtC family; Region: MgtC; pfam02308
582899003735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899003736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899003737	putative substrate translocation pore; other site
582899003738	YHS domain; Region: YHS; pfam04945
582899003739	YHS domain; Region: YHS; pfam04945
582899003740	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
582899003741	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582899003742	Soluble P-type ATPase [General function prediction only]; Region: COG4087
582899003743	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
582899003744	putative homodimer interface [polypeptide binding]; other site
582899003745	putative homotetramer interface [polypeptide binding]; other site
582899003746	putative allosteric switch controlling residues; other site
582899003747	putative metal binding site [ion binding]; other site
582899003748	putative homodimer-homodimer interface [polypeptide binding]; other site
582899003749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
582899003750	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899003751	LssY C-terminus; Region: LssY_C; pfam14067
582899003752	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
582899003753	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
582899003754	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
582899003755	CAP-like domain; other site
582899003756	active site
582899003757	primary dimer interface [polypeptide binding]; other site
582899003758	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582899003759	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
582899003760	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
582899003761	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
582899003762	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
582899003763	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582899003764	homodimer interface [polypeptide binding]; other site
582899003765	substrate-cofactor binding pocket; other site
582899003766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899003767	catalytic residue [active]
582899003768	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
582899003769	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
582899003770	aminotransferase; Validated; Region: PRK09148
582899003771	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899003772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899003773	homodimer interface [polypeptide binding]; other site
582899003774	catalytic residue [active]
582899003775	homoserine dehydrogenase; Provisional; Region: PRK06349
582899003776	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
582899003777	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
582899003778	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
582899003779	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
582899003780	putative active site [active]
582899003781	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
582899003782	DHH family; Region: DHH; pfam01368
582899003783	DHHA1 domain; Region: DHHA1; pfam02272
582899003784	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
582899003785	active site
582899003786	catalytic residues [active]
582899003787	DNA binding site [nucleotide binding]
582899003788	Int/Topo IB signature motif; other site
582899003789	Helix-turn-helix domain; Region: HTH_17; pfam12728
582899003790	HNH endonuclease; Region: HNH_3; pfam13392
582899003791	AP2 domain; Region: AP2; pfam00847
582899003792	DNA binding site [nucleotide binding]
582899003793	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
582899003794	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
582899003795	active site
582899003796	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
582899003797	ERF superfamily; Region: ERF; pfam04404
582899003798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899003799	sequence-specific DNA binding site [nucleotide binding]; other site
582899003800	salt bridge; other site
582899003801	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886
582899003802	Transcription antiterminator [Transcription]; Region: NusG; COG0250
582899003803	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
582899003804	Predicted transcriptional regulator [Transcription]; Region: COG2944
582899003805	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
582899003806	Terminase small subunit; Region: Terminase_2; cl01513
582899003807	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
582899003808	Phage stabilisation protein; Region: Phage_stabilize; pfam11134
582899003809	HNH endonuclease; Region: HNH_3; pfam13392
582899003810	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
582899003811	TIGR02594 family protein; Region: TIGR02594
582899003812	HNH endonuclease; Region: HNH_3; pfam13392
582899003813	AP2 domain; Region: AP2; pfam00847
582899003814	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
582899003815	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582899003816	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
582899003817	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
582899003818	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
582899003819	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
582899003820	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899003821	catalytic residues [active]
582899003822	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
582899003823	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
582899003824	domain_subunit interface; other site
582899003825	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
582899003826	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
582899003827	FTR, proximal lobe; Region: FTR_C; pfam02741
582899003828	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
582899003829	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582899003830	active site
582899003831	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
582899003832	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
582899003833	putative [4Fe-4S] binding site [ion binding]; other site
582899003834	putative molybdopterin cofactor binding site [chemical binding]; other site
582899003835	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582899003836	putative hydrophobic ligand binding site [chemical binding]; other site
582899003837	protein interface [polypeptide binding]; other site
582899003838	gate; other site
582899003839	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582899003840	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003841	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582899003842	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899003843	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899003844	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
582899003845	Trp docking motif [polypeptide binding]; other site
582899003846	dimer interface [polypeptide binding]; other site
582899003847	active site
582899003848	small subunit binding site [polypeptide binding]; other site
582899003849	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
582899003850	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
582899003851	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
582899003852	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899003853	substrate binding pocket [chemical binding]; other site
582899003854	membrane-bound complex binding site; other site
582899003855	hinge residues; other site
582899003856	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
582899003857	active site residue [active]
582899003858	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
582899003859	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
582899003860	TrkA-N domain; Region: TrkA_N; pfam02254
582899003861	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
582899003862	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
582899003863	TPP-binding site [chemical binding]; other site
582899003864	dimer interface [polypeptide binding]; other site
582899003865	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582899003866	PYR/PP interface [polypeptide binding]; other site
582899003867	dimer interface [polypeptide binding]; other site
582899003868	TPP binding site [chemical binding]; other site
582899003869	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582899003870	Phosphoglycerate kinase; Region: PGK; pfam00162
582899003871	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
582899003872	substrate binding site [chemical binding]; other site
582899003873	hinge regions; other site
582899003874	ADP binding site [chemical binding]; other site
582899003875	catalytic site [active]
582899003876	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
582899003877	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
582899003878	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
582899003879	substrate binding site [chemical binding]; other site
582899003880	dimer interface [polypeptide binding]; other site
582899003881	ATP binding site [chemical binding]; other site
582899003882	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
582899003883	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
582899003884	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
582899003885	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
582899003886	active site
582899003887	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582899003888	putative binding surface; other site
582899003889	active site
582899003890	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
582899003891	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582899003892	catalytic loop [active]
582899003893	iron binding site [ion binding]; other site
582899003894	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
582899003895	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899003896	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899003897	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
582899003898	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582899003899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
582899003900	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899003901	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899003902	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
582899003903	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
582899003904	glucosyltransferase MdoH; Provisional; Region: PRK05454
582899003905	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
582899003906	active site
582899003907	hypothetical protein; Provisional; Region: PRK05415
582899003908	Domain of unknown function (DUF697); Region: DUF697; cl12064
582899003909	YcjX-like family, DUF463; Region: DUF463; pfam04317
582899003910	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
582899003911	Predicted metalloprotease [General function prediction only]; Region: COG2321
582899003912	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
582899003913	Sporulation related domain; Region: SPOR; cl10051
582899003914	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
582899003915	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
582899003916	Substrate binding site; other site
582899003917	Mg++ binding site; other site
582899003918	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
582899003919	active site
582899003920	substrate binding site [chemical binding]; other site
582899003921	CoA binding site [chemical binding]; other site
582899003922	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
582899003923	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
582899003924	glutaminase active site [active]
582899003925	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
582899003926	dimer interface [polypeptide binding]; other site
582899003927	active site
582899003928	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
582899003929	dimer interface [polypeptide binding]; other site
582899003930	active site
582899003931	TPR repeat; Region: TPR_11; pfam13414
582899003932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899003933	binding surface
582899003934	TPR motif; other site
582899003935	Sporulation related domain; Region: SPOR; pfam05036
582899003936	Uncharacterized conserved protein [Function unknown]; Region: COG2928
582899003937	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
582899003938	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
582899003939	generic binding surface II; other site
582899003940	ssDNA binding site; other site
582899003941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899003942	ATP binding site [chemical binding]; other site
582899003943	putative Mg++ binding site [ion binding]; other site
582899003944	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899003945	nucleotide binding region [chemical binding]; other site
582899003946	ATP-binding site [chemical binding]; other site
582899003947	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
582899003948	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
582899003949	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
582899003950	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899003951	ATP binding site [chemical binding]; other site
582899003952	putative Mg++ binding site [ion binding]; other site
582899003953	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899003954	nucleotide binding region [chemical binding]; other site
582899003955	ATP-binding site [chemical binding]; other site
582899003956	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
582899003957	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
582899003958	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582899003959	acyl-activating enzyme (AAE) consensus motif; other site
582899003960	AMP binding site [chemical binding]; other site
582899003961	active site
582899003962	CoA binding site [chemical binding]; other site
582899003963	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
582899003964	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
582899003965	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
582899003966	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
582899003967	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582899003968	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
582899003969	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582899003970	active site
582899003971	Protein of unknown function, DUF486; Region: DUF486; cl01236
582899003972	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
582899003973	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
582899003974	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
582899003975	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
582899003976	putative acyl-acceptor binding pocket; other site
582899003977	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
582899003978	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899003979	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899003980	Septum formation initiator; Region: DivIC; cl17659
582899003981	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
582899003982	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
582899003983	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
582899003984	putative coenzyme Q binding site [chemical binding]; other site
582899003985	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
582899003986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899003987	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899003988	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899003989	Competence-damaged protein; Region: CinA; pfam02464
582899003990	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582899003991	MarR family; Region: MarR_2; cl17246
582899003992	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
582899003993	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
582899003994	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
582899003995	substrate binding site; other site
582899003996	dimer interface; other site
582899003997	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
582899003998	homotrimer interaction site [polypeptide binding]; other site
582899003999	zinc binding site [ion binding]; other site
582899004000	CDP-binding sites; other site
582899004001	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
582899004002	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
582899004003	FMN binding site [chemical binding]; other site
582899004004	active site
582899004005	catalytic residues [active]
582899004006	substrate binding site [chemical binding]; other site
582899004007	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582899004008	PAS domain; Region: PAS; smart00091
582899004009	putative active site [active]
582899004010	heme pocket [chemical binding]; other site
582899004011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899004012	dimer interface [polypeptide binding]; other site
582899004013	phosphorylation site [posttranslational modification]
582899004014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899004015	ATP binding site [chemical binding]; other site
582899004016	Mg2+ binding site [ion binding]; other site
582899004017	G-X-G motif; other site
582899004018	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
582899004019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899004020	active site
582899004021	phosphorylation site [posttranslational modification]
582899004022	intermolecular recognition site; other site
582899004023	dimerization interface [polypeptide binding]; other site
582899004024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899004025	Walker A motif; other site
582899004026	ATP binding site [chemical binding]; other site
582899004027	Walker B motif; other site
582899004028	arginine finger; other site
582899004029	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
582899004030	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
582899004031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899004032	dimerization interface [polypeptide binding]; other site
582899004033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899004034	putative active site [active]
582899004035	heme pocket [chemical binding]; other site
582899004036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899004037	dimer interface [polypeptide binding]; other site
582899004038	phosphorylation site [posttranslational modification]
582899004039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899004040	ATP binding site [chemical binding]; other site
582899004041	Mg2+ binding site [ion binding]; other site
582899004042	G-X-G motif; other site
582899004043	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582899004044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899004045	active site
582899004046	phosphorylation site [posttranslational modification]
582899004047	intermolecular recognition site; other site
582899004048	dimerization interface [polypeptide binding]; other site
582899004049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899004050	Walker A motif; other site
582899004051	ATP binding site [chemical binding]; other site
582899004052	Walker B motif; other site
582899004053	arginine finger; other site
582899004054	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582899004055	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
582899004056	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
582899004057	homodimer interface [polypeptide binding]; other site
582899004058	substrate-cofactor binding pocket; other site
582899004059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899004060	catalytic residue [active]
582899004061	bacterial Hfq-like; Region: Hfq; cd01716
582899004062	hexamer interface [polypeptide binding]; other site
582899004063	Sm1 motif; other site
582899004064	RNA binding site [nucleotide binding]; other site
582899004065	Sm2 motif; other site
582899004066	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
582899004067	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
582899004068	HflX GTPase family; Region: HflX; cd01878
582899004069	G1 box; other site
582899004070	GTP/Mg2+ binding site [chemical binding]; other site
582899004071	Switch I region; other site
582899004072	G2 box; other site
582899004073	G3 box; other site
582899004074	Switch II region; other site
582899004075	G4 box; other site
582899004076	G5 box; other site
582899004077	hypothetical protein; Provisional; Region: PRK06185
582899004078	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582899004079	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899004080	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
582899004081	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
582899004082	homodimer interface [polypeptide binding]; other site
582899004083	metal binding site [ion binding]; metal-binding site
582899004084	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
582899004085	homodimer interface [polypeptide binding]; other site
582899004086	active site
582899004087	putative chemical substrate binding site [chemical binding]; other site
582899004088	metal binding site [ion binding]; metal-binding site
582899004089	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
582899004090	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582899004091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899004092	Coenzyme A binding pocket [chemical binding]; other site
582899004093	RibD C-terminal domain; Region: RibD_C; cl17279
582899004094	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
582899004095	multifunctional aminopeptidase A; Provisional; Region: PRK00913
582899004096	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
582899004097	interface (dimer of trimers) [polypeptide binding]; other site
582899004098	Substrate-binding/catalytic site; other site
582899004099	Zn-binding sites [ion binding]; other site
582899004100	Predicted permeases [General function prediction only]; Region: COG0795
582899004101	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582899004102	Predicted permeases [General function prediction only]; Region: COG0795
582899004103	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582899004104	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
582899004105	OstA-like protein; Region: OstA; cl00844
582899004106	Organic solvent tolerance protein; Region: OstA_C; pfam04453
582899004107	SurA N-terminal domain; Region: SurA_N; pfam09312
582899004108	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
582899004109	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
582899004110	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
582899004111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899004112	S-adenosylmethionine binding site [chemical binding]; other site
582899004113	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
582899004114	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
582899004115	catalytic site [active]
582899004116	G-X2-G-X-G-K; other site
582899004117	hypothetical protein; Provisional; Region: PRK11820
582899004118	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
582899004119	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
582899004120	YceG-like family; Region: YceG; pfam02618
582899004121	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
582899004122	dimerization interface [polypeptide binding]; other site
582899004123	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
582899004124	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582899004125	dimer interface [polypeptide binding]; other site
582899004126	active site
582899004127	acyl carrier protein; Provisional; Region: acpP; PRK00982
582899004128	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
582899004129	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
582899004130	NAD(P) binding site [chemical binding]; other site
582899004131	homotetramer interface [polypeptide binding]; other site
582899004132	homodimer interface [polypeptide binding]; other site
582899004133	active site
582899004134	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
582899004135	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
582899004136	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
582899004137	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899004138	putative metal binding site [ion binding]; other site
582899004139	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
582899004140	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
582899004141	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
582899004142	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
582899004143	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
582899004144	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
582899004145	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
582899004146	replicative DNA helicase; Provisional; Region: PRK09165
582899004147	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
582899004148	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
582899004149	Walker A motif; other site
582899004150	ATP binding site [chemical binding]; other site
582899004151	Walker B motif; other site
582899004152	DNA binding loops [nucleotide binding]
582899004153	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
582899004154	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
582899004155	active site
582899004156	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582899004157	dimer interface [polypeptide binding]; other site
582899004158	substrate binding site [chemical binding]; other site
582899004159	catalytic residues [active]
582899004160	DNA repair protein RadA; Provisional; Region: PRK11823
582899004161	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
582899004162	Walker A motif/ATP binding site; other site
582899004163	ATP binding site [chemical binding]; other site
582899004164	Walker B motif; other site
582899004165	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
582899004166	Colicin V production protein; Region: Colicin_V; pfam02674
582899004167	amidophosphoribosyltransferase; Provisional; Region: PRK09123
582899004168	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
582899004169	active site
582899004170	tetramer interface [polypeptide binding]; other site
582899004171	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899004172	active site
582899004173	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582899004174	classical (c) SDRs; Region: SDR_c; cd05233
582899004175	NAD(P) binding site [chemical binding]; other site
582899004176	active site
582899004177	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
582899004178	putative hydrolase; Provisional; Region: PRK02113
582899004179	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
582899004180	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
582899004181	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
582899004182	active site
582899004183	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
582899004184	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
582899004185	active site
582899004186	HIGH motif; other site
582899004187	KMSKS motif; other site
582899004188	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
582899004189	anticodon binding site; other site
582899004190	tRNA binding surface [nucleotide binding]; other site
582899004191	DNA polymerase III subunit delta'; Validated; Region: PRK07471
582899004192	DNA polymerase III subunit delta'; Validated; Region: PRK08485
582899004193	thymidylate kinase; Validated; Region: tmk; PRK00698
582899004194	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
582899004195	TMP-binding site; other site
582899004196	ATP-binding site [chemical binding]; other site
582899004197	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
582899004198	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
582899004199	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
582899004200	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
582899004201	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
582899004202	Sporulation related domain; Region: SPOR; pfam05036
582899004203	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582899004204	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
582899004205	active site
582899004206	Int/Topo IB signature motif; other site
582899004207	Helix-turn-helix domain; Region: HTH_17; cl17695
582899004208	Toprim domain; Region: Toprim_3; pfam13362
582899004209	active site
582899004210	metal binding site [ion binding]; metal-binding site
582899004211	D5 N terminal like; Region: D5_N; smart00885
582899004212	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582899004213	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899004214	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899004215	YtkA-like; Region: YtkA; pfam13115
582899004216	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
582899004217	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
582899004218	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
582899004219	DNA binding residues [nucleotide binding]
582899004220	dimer interface [polypeptide binding]; other site
582899004221	putative metal binding site [ion binding]; other site
582899004222	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899004223	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
582899004224	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899004225	N-terminal plug; other site
582899004226	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582899004227	ligand-binding site [chemical binding]; other site
582899004228	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
582899004229	putative ligand binding residues [chemical binding]; other site
582899004230	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
582899004231	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582899004232	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
582899004233	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
582899004234	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
582899004235	dimer interface [polypeptide binding]; other site
582899004236	putative PBP binding regions; other site
582899004237	ABC-ATPase subunit  interface; other site
582899004238	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
582899004239	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
582899004240	Walker A/P-loop; other site
582899004241	ATP binding site [chemical binding]; other site
582899004242	Q-loop/lid; other site
582899004243	ABC transporter signature motif; other site
582899004244	Walker B; other site
582899004245	D-loop; other site
582899004246	H-loop/switch region; other site
582899004247	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
582899004248	Predicted transcriptional regulators [Transcription]; Region: COG1695
582899004249	Transcriptional regulator PadR-like family; Region: PadR; cl17335
582899004250	Cupin domain; Region: Cupin_2; cl17218
582899004251	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582899004252	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899004253	P-loop; other site
582899004254	Magnesium ion binding site [ion binding]; other site
582899004255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899004256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899004257	dimer interface [polypeptide binding]; other site
582899004258	phosphorylation site [posttranslational modification]
582899004259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899004260	ATP binding site [chemical binding]; other site
582899004261	Mg2+ binding site [ion binding]; other site
582899004262	G-X-G motif; other site
582899004263	Response regulator receiver domain; Region: Response_reg; pfam00072
582899004264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899004265	active site
582899004266	phosphorylation site [posttranslational modification]
582899004267	intermolecular recognition site; other site
582899004268	dimerization interface [polypeptide binding]; other site
582899004269	enolase; Provisional; Region: eno; PRK00077
582899004270	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
582899004271	dimer interface [polypeptide binding]; other site
582899004272	metal binding site [ion binding]; metal-binding site
582899004273	substrate binding pocket [chemical binding]; other site
582899004274	Uncharacterized conserved protein [Function unknown]; Region: COG3791
582899004275	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
582899004276	Ligand Binding Site [chemical binding]; other site
582899004277	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
582899004278	CoenzymeA binding site [chemical binding]; other site
582899004279	subunit interaction site [polypeptide binding]; other site
582899004280	PHB binding site; other site
582899004281	Radical SAM superfamily; Region: Radical_SAM; pfam04055
582899004282	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
582899004283	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
582899004284	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899004285	FeS/SAM binding site; other site
582899004286	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
582899004287	active site
582899004288	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
582899004289	Pirin-related protein [General function prediction only]; Region: COG1741
582899004290	Pirin; Region: Pirin; pfam02678
582899004291	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
582899004292	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
582899004293	Protein of unknown function (DUF992); Region: DUF992; pfam06186
582899004294	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
582899004295	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
582899004296	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
582899004297	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
582899004298	active site
582899004299	dimer interface [polypeptide binding]; other site
582899004300	motif 1; other site
582899004301	motif 2; other site
582899004302	motif 3; other site
582899004303	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
582899004304	anticodon binding site; other site
582899004305	hypothetical protein; Validated; Region: PRK00041
582899004306	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
582899004307	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
582899004308	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
582899004309	trimerization site [polypeptide binding]; other site
582899004310	active site
582899004311	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
582899004312	GTP cyclohydrolase I; Provisional; Region: PLN03044
582899004313	active site
582899004314	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
582899004315	hypothetical protein; Provisional; Region: PRK10279
582899004316	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582899004317	nucleophile elbow; other site
582899004318	FOG: CBS domain [General function prediction only]; Region: COG0517
582899004319	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
582899004320	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
582899004321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
582899004322	PAS domain; Region: PAS_5; pfam07310
582899004323	PilZ domain; Region: PilZ; pfam07238
582899004324	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
582899004325	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
582899004326	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
582899004327	trimer interface [polypeptide binding]; other site
582899004328	putative metal binding site [ion binding]; other site
582899004329	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
582899004330	serine acetyltransferase; Provisional; Region: cysE; PRK11132
582899004331	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
582899004332	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
582899004333	trimer interface [polypeptide binding]; other site
582899004334	active site
582899004335	substrate binding site [chemical binding]; other site
582899004336	CoA binding site [chemical binding]; other site
582899004337	enoyl-CoA hydratase; Provisional; Region: PRK06127
582899004338	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582899004339	substrate binding site [chemical binding]; other site
582899004340	oxyanion hole (OAH) forming residues; other site
582899004341	trimer interface [polypeptide binding]; other site
582899004342	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582899004343	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
582899004344	NodB motif; other site
582899004345	putative active site [active]
582899004346	putative catalytic site [active]
582899004347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899004348	Coenzyme A binding pocket [chemical binding]; other site
582899004349	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
582899004350	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
582899004351	substrate binding pocket [chemical binding]; other site
582899004352	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
582899004353	B12 binding site [chemical binding]; other site
582899004354	cobalt ligand [ion binding]; other site
582899004355	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
582899004356	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
582899004357	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
582899004358	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
582899004359	FAD binding site [chemical binding]; other site
582899004360	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899004361	dimerization interface [polypeptide binding]; other site
582899004362	putative DNA binding site [nucleotide binding]; other site
582899004363	putative Zn2+ binding site [ion binding]; other site
582899004364	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582899004365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899004366	S-adenosylmethionine binding site [chemical binding]; other site
582899004367	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
582899004368	PRC-barrel domain; Region: PRC; pfam05239
582899004369	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
582899004370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899004371	Walker A/P-loop; other site
582899004372	ATP binding site [chemical binding]; other site
582899004373	Q-loop/lid; other site
582899004374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899004375	ABC transporter signature motif; other site
582899004376	Walker B; other site
582899004377	D-loop; other site
582899004378	ABC transporter; Region: ABC_tran_2; pfam12848
582899004379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899004380	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
582899004381	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
582899004382	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582899004383	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899004384	putative DNA binding site [nucleotide binding]; other site
582899004385	putative Zn2+ binding site [ion binding]; other site
582899004386	AsnC family; Region: AsnC_trans_reg; pfam01037
582899004387	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
582899004388	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
582899004389	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
582899004390	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
582899004391	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582899004392	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582899004393	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
582899004394	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582899004395	ATP-grasp domain; Region: ATP-grasp_4; cl17255
582899004396	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
582899004397	IMP binding site; other site
582899004398	dimer interface [polypeptide binding]; other site
582899004399	interdomain contacts; other site
582899004400	partial ornithine binding site; other site
582899004401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899004402	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899004403	putative substrate translocation pore; other site
582899004404	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
582899004405	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
582899004406	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
582899004407	catalytic site [active]
582899004408	subunit interface [polypeptide binding]; other site
582899004409	Yqey-like protein; Region: YqeY; pfam09424
582899004410	DNA primase; Validated; Region: dnaG; PRK05667
582899004411	CHC2 zinc finger; Region: zf-CHC2; pfam01807
582899004412	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
582899004413	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
582899004414	active site
582899004415	metal binding site [ion binding]; metal-binding site
582899004416	interdomain interaction site; other site
582899004417	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
582899004418	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
582899004419	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
582899004420	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582899004421	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
582899004422	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899004423	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
582899004424	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899004425	DNA binding residues [nucleotide binding]
582899004426	EthD domain; Region: EthD; cl17553
582899004427	transcription elongation factor regulatory protein; Validated; Region: PRK06342
582899004428	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
582899004429	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
582899004430	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
582899004431	Predicted amidohydrolase [General function prediction only]; Region: COG0388
582899004432	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
582899004433	putative active site [active]
582899004434	catalytic triad [active]
582899004435	putative dimer interface [polypeptide binding]; other site
582899004436	Uncharacterized conserved protein [Function unknown]; Region: COG2968
582899004437	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
582899004438	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
582899004439	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
582899004440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
582899004441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899004442	Coenzyme A binding pocket [chemical binding]; other site
582899004443	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
582899004444	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
582899004445	phosphate binding site [ion binding]; other site
582899004446	Cyclophilin-like; Region: Cyclophil_like; cl17583
582899004447	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
582899004448	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582899004449	dimer interface [polypeptide binding]; other site
582899004450	active site
582899004451	acyl carrier protein; Provisional; Region: acpP; PRK00982
582899004452	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
582899004453	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
582899004454	acyl-activating enzyme (AAE) consensus motif; other site
582899004455	putative AMP binding site [chemical binding]; other site
582899004456	putative active site [active]
582899004457	putative CoA binding site [chemical binding]; other site
582899004458	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
582899004459	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582899004460	active site
582899004461	HIGH motif; other site
582899004462	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582899004463	KMSKS motif; other site
582899004464	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
582899004465	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
582899004466	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
582899004467	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899004468	active site
582899004469	HIGH motif; other site
582899004470	nucleotide binding site [chemical binding]; other site
582899004471	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582899004472	active site
582899004473	KMSKS motif; other site
582899004474	NAD synthetase; Provisional; Region: PRK13981
582899004475	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
582899004476	multimer interface [polypeptide binding]; other site
582899004477	active site
582899004478	catalytic triad [active]
582899004479	protein interface 1 [polypeptide binding]; other site
582899004480	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
582899004481	homodimer interface [polypeptide binding]; other site
582899004482	NAD binding pocket [chemical binding]; other site
582899004483	ATP binding pocket [chemical binding]; other site
582899004484	Mg binding site [ion binding]; other site
582899004485	active-site loop [active]
582899004486	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582899004487	Ligand Binding Site [chemical binding]; other site
582899004488	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
582899004489	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582899004490	classical (c) SDRs; Region: SDR_c; cd05233
582899004491	NAD(P) binding site [chemical binding]; other site
582899004492	active site
582899004493	glutathione reductase; Validated; Region: PRK06116
582899004494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899004495	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899004496	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899004497	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
582899004498	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
582899004499	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582899004500	active site
582899004501	dimer interface [polypeptide binding]; other site
582899004502	phosphoglycolate phosphatase; Provisional; Region: PRK13222
582899004503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899004504	motif II; other site
582899004505	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
582899004506	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
582899004507	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
582899004508	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
582899004509	methionine sulfoxide reductase A; Provisional; Region: PRK13014
582899004510	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
582899004511	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
582899004512	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582899004513	catalytic residue [active]
582899004514	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
582899004515	threonine dehydratase; Provisional; Region: PRK07334
582899004516	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
582899004517	tetramer interface [polypeptide binding]; other site
582899004518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899004519	catalytic residue [active]
582899004520	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
582899004521	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
582899004522	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
582899004523	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
582899004524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899004525	dimerization interface [polypeptide binding]; other site
582899004526	putative DNA binding site [nucleotide binding]; other site
582899004527	putative Zn2+ binding site [ion binding]; other site
582899004528	AsnC family; Region: AsnC_trans_reg; pfam01037
582899004529	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582899004530	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
582899004531	putative C-terminal domain interface [polypeptide binding]; other site
582899004532	putative GSH binding site (G-site) [chemical binding]; other site
582899004533	putative dimer interface [polypeptide binding]; other site
582899004534	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
582899004535	putative N-terminal domain interface [polypeptide binding]; other site
582899004536	putative dimer interface [polypeptide binding]; other site
582899004537	putative substrate binding pocket (H-site) [chemical binding]; other site
582899004538	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
582899004539	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
582899004540	Catalytic site; other site
582899004541	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899004542	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899004543	dimer interface [polypeptide binding]; other site
582899004544	phosphorylation site [posttranslational modification]
582899004545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899004546	ATP binding site [chemical binding]; other site
582899004547	Mg2+ binding site [ion binding]; other site
582899004548	G-X-G motif; other site
582899004549	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582899004550	catalytic motif [active]
582899004551	Catalytic residue [active]
582899004552	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582899004553	catalytic motif [active]
582899004554	Catalytic residue [active]
582899004555	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
582899004556	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
582899004557	active site
582899004558	substrate binding site [chemical binding]; other site
582899004559	metal binding site [ion binding]; metal-binding site
582899004560	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582899004561	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
582899004562	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
582899004563	FMN binding site [chemical binding]; other site
582899004564	active site
582899004565	catalytic residues [active]
582899004566	substrate binding site [chemical binding]; other site
582899004567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
582899004568	MOSC domain; Region: MOSC; pfam03473
582899004569	3-alpha domain; Region: 3-alpha; pfam03475
582899004570	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899004571	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
582899004572	Trp docking motif [polypeptide binding]; other site
582899004573	dimer interface [polypeptide binding]; other site
582899004574	active site
582899004575	small subunit binding site [polypeptide binding]; other site
582899004576	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582899004577	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582899004578	DNA-binding site [nucleotide binding]; DNA binding site
582899004579	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899004580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899004581	homodimer interface [polypeptide binding]; other site
582899004582	catalytic residue [active]
582899004583	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
582899004584	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899004585	ligand binding site [chemical binding]; other site
582899004586	flexible hinge region; other site
582899004587	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
582899004588	putative switch regulator; other site
582899004589	non-specific DNA interactions [nucleotide binding]; other site
582899004590	DNA binding site [nucleotide binding]
582899004591	sequence specific DNA binding site [nucleotide binding]; other site
582899004592	putative cAMP binding site [chemical binding]; other site
582899004593	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
582899004594	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
582899004595	cobalamin binding residues [chemical binding]; other site
582899004596	putative BtuC binding residues; other site
582899004597	dimer interface [polypeptide binding]; other site
582899004598	Cytochrome c; Region: Cytochrom_C; pfam00034
582899004599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
582899004600	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
582899004601	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
582899004602	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
582899004603	ApbE family; Region: ApbE; pfam02424
582899004604	NosL; Region: NosL; pfam05573
582899004605	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
582899004606	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
582899004607	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
582899004608	Walker A/P-loop; other site
582899004609	ATP binding site [chemical binding]; other site
582899004610	Q-loop/lid; other site
582899004611	ABC transporter signature motif; other site
582899004612	Walker B; other site
582899004613	D-loop; other site
582899004614	H-loop/switch region; other site
582899004615	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
582899004616	nitrous-oxide reductase; Validated; Region: PRK02888
582899004617	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
582899004618	regulatory protein interface [polypeptide binding]; other site
582899004619	active site
582899004620	regulatory phosphorylation site [posttranslational modification]; other site
582899004621	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
582899004622	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
582899004623	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
582899004624	4Fe-4S binding domain; Region: Fer4_5; pfam12801
582899004625	4Fe-4S binding domain; Region: Fer4_5; pfam12801
582899004626	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
582899004627	diiron binding motif [ion binding]; other site
582899004628	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899004629	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899004630	DNA binding residues [nucleotide binding]
582899004631	dimerization interface [polypeptide binding]; other site
582899004632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899004633	active site
582899004634	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
582899004635	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
582899004636	Autotransporter beta-domain; Region: Autotransporter; smart00869
582899004637	PilZ domain; Region: PilZ; pfam07238
582899004638	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899004639	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
582899004640	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
582899004641	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
582899004642	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
582899004643	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
582899004644	BRO family, N-terminal domain; Region: Bro-N; pfam02498
582899004645	LexA repressor; Validated; Region: PRK00215
582899004646	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
582899004647	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
582899004648	Catalytic site [active]
582899004649	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
582899004650	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
582899004651	Competence protein; Region: Competence; pfam03772
582899004652	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899004653	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
582899004654	active site
582899004655	HIGH motif; other site
582899004656	nucleotide binding site [chemical binding]; other site
582899004657	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582899004658	active site
582899004659	KMSKS motif; other site
582899004660	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
582899004661	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
582899004662	dimer interface [polypeptide binding]; other site
582899004663	active site
582899004664	citrylCoA binding site [chemical binding]; other site
582899004665	NADH binding [chemical binding]; other site
582899004666	cationic pore residues; other site
582899004667	oxalacetate/citrate binding site [chemical binding]; other site
582899004668	coenzyme A binding site [chemical binding]; other site
582899004669	catalytic triad [active]
582899004670	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
582899004671	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
582899004672	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
582899004673	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
582899004674	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
582899004675	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
582899004676	active site
582899004677	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
582899004678	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
582899004679	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
582899004680	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
582899004681	trimer interface [polypeptide binding]; other site
582899004682	active site
582899004683	UDP-GlcNAc binding site [chemical binding]; other site
582899004684	lipid binding site [chemical binding]; lipid-binding site
582899004685	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
582899004686	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582899004687	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582899004688	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582899004689	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582899004690	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
582899004691	Surface antigen; Region: Bac_surface_Ag; pfam01103
582899004692	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
582899004693	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
582899004694	active site
582899004695	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
582899004696	protein binding site [polypeptide binding]; other site
582899004697	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
582899004698	putative substrate binding region [chemical binding]; other site
582899004699	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
582899004700	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
582899004701	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
582899004702	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
582899004703	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
582899004704	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
582899004705	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
582899004706	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
582899004707	catalytic residue [active]
582899004708	putative FPP diphosphate  binding site; other site
582899004709	putative FPP binding hydrophobic cleft; other site
582899004710	dimer interface [polypeptide binding]; other site
582899004711	putative IPP diphosphate binding site; other site
582899004712	ribosome recycling factor; Reviewed; Region: frr; PRK00083
582899004713	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
582899004714	hinge region; other site
582899004715	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
582899004716	putative nucleotide binding site [chemical binding]; other site
582899004717	uridine monophosphate binding site [chemical binding]; other site
582899004718	homohexameric interface [polypeptide binding]; other site
582899004719	elongation factor Ts; Provisional; Region: tsf; PRK09377
582899004720	UBA/TS-N domain; Region: UBA; pfam00627
582899004721	Elongation factor TS; Region: EF_TS; pfam00889
582899004722	Elongation factor TS; Region: EF_TS; pfam00889
582899004723	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
582899004724	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
582899004725	rRNA interaction site [nucleotide binding]; other site
582899004726	S8 interaction site; other site
582899004727	putative laminin-1 binding site; other site
582899004728	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582899004729	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
582899004730	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
582899004731	putative active site [active]
582899004732	putative PHP Thumb interface [polypeptide binding]; other site
582899004733	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
582899004734	generic binding surface II; other site
582899004735	generic binding surface I; other site
582899004736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582899004737	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582899004738	Walker A/P-loop; other site
582899004739	ATP binding site [chemical binding]; other site
582899004740	Q-loop/lid; other site
582899004741	ABC transporter signature motif; other site
582899004742	Walker B; other site
582899004743	D-loop; other site
582899004744	H-loop/switch region; other site
582899004745	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
582899004746	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582899004747	FtsX-like permease family; Region: FtsX; pfam02687
582899004748	prolyl-tRNA synthetase; Provisional; Region: PRK08661
582899004749	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
582899004750	dimer interface [polypeptide binding]; other site
582899004751	motif 1; other site
582899004752	active site
582899004753	motif 2; other site
582899004754	motif 3; other site
582899004755	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
582899004756	anticodon binding site; other site
582899004757	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
582899004758	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899004759	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
582899004760	dimer interface [polypeptide binding]; other site
582899004761	substrate binding site [chemical binding]; other site
582899004762	metal binding site [ion binding]; metal-binding site
582899004763	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
582899004764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899004765	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
582899004766	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
582899004767	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
582899004768	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
582899004769	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
582899004770	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582899004771	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
582899004772	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582899004773	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
582899004774	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
582899004775	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
582899004776	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
582899004777	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
582899004778	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
582899004779	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
582899004780	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
582899004781	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
582899004782	4Fe-4S binding domain; Region: Fer4; pfam00037
582899004783	4Fe-4S binding domain; Region: Fer4; pfam00037
582899004784	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
582899004785	NADH dehydrogenase subunit G; Validated; Region: PRK09130
582899004786	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582899004787	catalytic loop [active]
582899004788	iron binding site [ion binding]; other site
582899004789	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
582899004790	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
582899004791	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
582899004792	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
582899004793	SLBB domain; Region: SLBB; pfam10531
582899004794	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
582899004795	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
582899004796	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
582899004797	putative dimer interface [polypeptide binding]; other site
582899004798	[2Fe-2S] cluster binding site [ion binding]; other site
582899004799	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582899004800	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
582899004801	NADH dehydrogenase subunit D; Validated; Region: PRK06075
582899004802	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
582899004803	active site 1 [active]
582899004804	active site 2 [active]
582899004805	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
582899004806	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
582899004807	NADH dehydrogenase subunit B; Validated; Region: PRK06411
582899004808	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
582899004809	CHASE2 domain; Region: CHASE2; pfam05226
582899004810	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
582899004811	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
582899004812	cyclase homology domain; Region: CHD; cd07302
582899004813	nucleotidyl binding site; other site
582899004814	metal binding site [ion binding]; metal-binding site
582899004815	dimer interface [polypeptide binding]; other site
582899004816	FecR protein; Region: FecR; pfam04773
582899004817	PAS fold; Region: PAS_7; pfam12860
582899004818	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899004819	metal binding site [ion binding]; metal-binding site
582899004820	active site
582899004821	I-site; other site
582899004822	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899004823	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
582899004824	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582899004825	IHF dimer interface [polypeptide binding]; other site
582899004826	IHF - DNA interface [nucleotide binding]; other site
582899004827	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
582899004828	Found in ATP-dependent protease La (LON); Region: LON; smart00464
582899004829	Found in ATP-dependent protease La (LON); Region: LON; smart00464
582899004830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899004831	Walker A motif; other site
582899004832	ATP binding site [chemical binding]; other site
582899004833	Walker B motif; other site
582899004834	arginine finger; other site
582899004835	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
582899004836	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
582899004837	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
582899004838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899004839	Walker A motif; other site
582899004840	ATP binding site [chemical binding]; other site
582899004841	Walker B motif; other site
582899004842	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
582899004843	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
582899004844	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
582899004845	oligomer interface [polypeptide binding]; other site
582899004846	active site residues [active]
582899004847	trigger factor; Provisional; Region: tig; PRK01490
582899004848	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582899004849	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
582899004850	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
582899004851	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
582899004852	active site residue [active]
582899004853	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
582899004854	active site residue [active]
582899004855	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
582899004856	catalytic residues [active]
582899004857	dimer interface [polypeptide binding]; other site
582899004858	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
582899004859	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899004860	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899004861	Esterase/lipase [General function prediction only]; Region: COG1647
582899004862	DevC protein; Region: devC; TIGR01185
582899004863	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582899004864	FtsX-like permease family; Region: FtsX; pfam02687
582899004865	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582899004866	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582899004867	Walker A/P-loop; other site
582899004868	ATP binding site [chemical binding]; other site
582899004869	Q-loop/lid; other site
582899004870	ABC transporter signature motif; other site
582899004871	Walker B; other site
582899004872	D-loop; other site
582899004873	H-loop/switch region; other site
582899004874	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
582899004875	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
582899004876	NAD binding site [chemical binding]; other site
582899004877	homotetramer interface [polypeptide binding]; other site
582899004878	homodimer interface [polypeptide binding]; other site
582899004879	substrate binding site [chemical binding]; other site
582899004880	active site
582899004881	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582899004882	catalytic core [active]
582899004883	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
582899004884	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
582899004885	Tetramer interface [polypeptide binding]; other site
582899004886	active site
582899004887	FMN-binding site [chemical binding]; other site
582899004888	TRAM domain; Region: TRAM; cl01282
582899004889	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
582899004890	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
582899004891	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899004892	RNA binding surface [nucleotide binding]; other site
582899004893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899004894	S-adenosylmethionine binding site [chemical binding]; other site
582899004895	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
582899004896	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
582899004897	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
582899004898	TPP-binding site; other site
582899004899	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582899004900	PYR/PP interface [polypeptide binding]; other site
582899004901	dimer interface [polypeptide binding]; other site
582899004902	TPP binding site [chemical binding]; other site
582899004903	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582899004904	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
582899004905	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
582899004906	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
582899004907	putative active site [active]
582899004908	Zn binding site [ion binding]; other site
582899004909	short chain dehydrogenase; Provisional; Region: PRK08278
582899004910	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
582899004911	NAD(P) binding site [chemical binding]; other site
582899004912	homodimer interface [polypeptide binding]; other site
582899004913	active site
582899004914	enoyl-CoA hydratase; Provisional; Region: PRK06688
582899004915	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
582899004916	substrate binding site [chemical binding]; other site
582899004917	oxyanion hole (OAH) forming residues; other site
582899004918	trimer interface [polypeptide binding]; other site
582899004919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
582899004920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582899004921	active site
582899004922	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
582899004923	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
582899004924	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
582899004925	Acyltransferase family; Region: Acyl_transf_3; pfam01757
582899004926	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
582899004927	Uncharacterized conserved protein [Function unknown]; Region: COG2135
582899004928	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
582899004929	LysE type translocator; Region: LysE; cl00565
582899004930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
582899004931	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899004932	dihydroorotase; Validated; Region: PRK09060
582899004933	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
582899004934	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
582899004935	active site
582899004936	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
582899004937	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
582899004938	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582899004939	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
582899004940	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
582899004941	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
582899004942	quinolinate synthetase; Provisional; Region: PRK09375
582899004943	L-aspartate oxidase; Provisional; Region: PRK07512
582899004944	L-aspartate oxidase; Provisional; Region: PRK06175
582899004945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
582899004946	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
582899004947	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
582899004948	dimerization interface [polypeptide binding]; other site
582899004949	active site
582899004950	pyruvate phosphate dikinase; Provisional; Region: PRK09279
582899004951	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
582899004952	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
582899004953	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
582899004954	hypothetical protein; Validated; Region: PRK09104
582899004955	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
582899004956	metal binding site [ion binding]; metal-binding site
582899004957	putative dimer interface [polypeptide binding]; other site
582899004958	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
582899004959	B1 nucleotide binding pocket [chemical binding]; other site
582899004960	B2 nucleotide binding pocket [chemical binding]; other site
582899004961	CAS motifs; other site
582899004962	active site
582899004963	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
582899004964	short chain dehydrogenase; Provisional; Region: PRK12939
582899004965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899004966	NAD(P) binding site [chemical binding]; other site
582899004967	active site
582899004968	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
582899004969	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
582899004970	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
582899004971	GIY-YIG motif/motif A; other site
582899004972	active site
582899004973	catalytic site [active]
582899004974	putative DNA binding site [nucleotide binding]; other site
582899004975	metal binding site [ion binding]; metal-binding site
582899004976	UvrB/uvrC motif; Region: UVR; pfam02151
582899004977	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
582899004978	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
582899004979	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
582899004980	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582899004981	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
582899004982	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
582899004983	MoaE interaction surface [polypeptide binding]; other site
582899004984	MoeB interaction surface [polypeptide binding]; other site
582899004985	thiocarboxylated glycine; other site
582899004986	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
582899004987	MoaE homodimer interface [polypeptide binding]; other site
582899004988	MoaD interaction [polypeptide binding]; other site
582899004989	active site residues [active]
582899004990	AMIN domain; Region: AMIN; pfam11741
582899004991	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
582899004992	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
582899004993	active site
582899004994	metal binding site [ion binding]; metal-binding site
582899004995	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
582899004996	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
582899004997	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
582899004998	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582899004999	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899005000	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899005001	DNA binding residues [nucleotide binding]
582899005002	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
582899005003	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899005004	RNA binding surface [nucleotide binding]; other site
582899005005	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
582899005006	active site
582899005007	Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607
582899005008	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
582899005009	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
582899005010	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582899005011	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
582899005012	high affinity sulphate transporter 1; Region: sulP; TIGR00815
582899005013	Sulfate transporter family; Region: Sulfate_transp; pfam00916
582899005014	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
582899005015	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
582899005016	phosphate acetyltransferase; Provisional; Region: PRK11890
582899005017	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
582899005018	propionate/acetate kinase; Provisional; Region: PRK12379
582899005019	Acetokinase family; Region: Acetate_kinase; cl17229
582899005020	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
582899005021	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
582899005022	NAD binding site [chemical binding]; other site
582899005023	homotetramer interface [polypeptide binding]; other site
582899005024	homodimer interface [polypeptide binding]; other site
582899005025	substrate binding site [chemical binding]; other site
582899005026	active site
582899005027	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582899005028	Ligand Binding Site [chemical binding]; other site
582899005029	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582899005030	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899005031	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899005032	Domain of unknown function DUF20; Region: UPF0118; pfam01594
582899005033	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
582899005034	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899005035	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899005036	DNA binding residues [nucleotide binding]
582899005037	dimerization interface [polypeptide binding]; other site
582899005038	PRC-barrel domain; Region: PRC; pfam05239
582899005039	Family description; Region: DsbD_2; pfam13386
582899005040	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
582899005041	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
582899005042	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
582899005043	metal-binding site [ion binding]
582899005044	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582899005045	Soluble P-type ATPase [General function prediction only]; Region: COG4087
582899005046	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
582899005047	FixH; Region: FixH; pfam05751
582899005048	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
582899005049	4Fe-4S binding domain; Region: Fer4_5; pfam12801
582899005050	4Fe-4S binding domain; Region: Fer4; cl02805
582899005051	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
582899005052	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
582899005053	Cytochrome c; Region: Cytochrom_C; pfam00034
582899005054	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
582899005055	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
582899005056	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
582899005057	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
582899005058	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
582899005059	Low-spin heme binding site [chemical binding]; other site
582899005060	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
582899005061	Putative water exit pathway; other site
582899005062	Binuclear center (active site) [active]
582899005063	Putative proton exit pathway; other site
582899005064	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
582899005065	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899005066	NAD(P) binding site [chemical binding]; other site
582899005067	active site
582899005068	acetate kinase; Provisional; Region: PRK07058
582899005069	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
582899005070	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
582899005071	dimer interaction site [polypeptide binding]; other site
582899005072	substrate-binding tunnel; other site
582899005073	active site
582899005074	catalytic site [active]
582899005075	substrate binding site [chemical binding]; other site
582899005076	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
582899005077	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
582899005078	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
582899005079	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
582899005080	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
582899005081	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
582899005082	THF binding site; other site
582899005083	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
582899005084	substrate binding site [chemical binding]; other site
582899005085	THF binding site; other site
582899005086	zinc-binding site [ion binding]; other site
582899005087	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
582899005088	isocitrate lyase; Provisional; Region: PRK15063
582899005089	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
582899005090	tetramer interface [polypeptide binding]; other site
582899005091	active site
582899005092	Mg2+/Mn2+ binding site [ion binding]; other site
582899005093	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582899005094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899005095	non-specific DNA binding site [nucleotide binding]; other site
582899005096	salt bridge; other site
582899005097	sequence-specific DNA binding site [nucleotide binding]; other site
582899005098	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
582899005099	Domain of unknown function (DUF955); Region: DUF955; pfam06114
582899005100	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
582899005101	Domain of unknown function (DUF955); Region: DUF955; pfam06114
582899005102	Predicted transcriptional regulators [Transcription]; Region: COG1510
582899005103	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899005104	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
582899005105	active site
582899005106	nucleophile elbow; other site
582899005107	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
582899005108	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
582899005109	2-isopropylmalate synthase; Validated; Region: PRK00915
582899005110	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
582899005111	active site
582899005112	catalytic residues [active]
582899005113	metal binding site [ion binding]; metal-binding site
582899005114	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
582899005115	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
582899005116	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
582899005117	NUDIX domain; Region: NUDIX; pfam00293
582899005118	nudix motif; other site
582899005119	ketol-acid reductoisomerase; Provisional; Region: PRK05479
582899005120	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
582899005121	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
582899005122	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
582899005123	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
582899005124	putative valine binding site [chemical binding]; other site
582899005125	dimer interface [polypeptide binding]; other site
582899005126	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
582899005127	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
582899005128	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582899005129	putative C-terminal domain interface [polypeptide binding]; other site
582899005130	putative GSH binding site (G-site) [chemical binding]; other site
582899005131	putative dimer interface [polypeptide binding]; other site
582899005132	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
582899005133	putative N-terminal domain interface [polypeptide binding]; other site
582899005134	putative dimer interface [polypeptide binding]; other site
582899005135	putative substrate binding pocket (H-site) [chemical binding]; other site
582899005136	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
582899005137	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
582899005138	PYR/PP interface [polypeptide binding]; other site
582899005139	dimer interface [polypeptide binding]; other site
582899005140	TPP binding site [chemical binding]; other site
582899005141	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
582899005142	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
582899005143	TPP-binding site [chemical binding]; other site
582899005144	dimer interface [polypeptide binding]; other site
582899005145	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
582899005146	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
582899005147	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
582899005148	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
582899005149	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
582899005150	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582899005151	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
582899005152	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
582899005153	Walker A/P-loop; other site
582899005154	ATP binding site [chemical binding]; other site
582899005155	Q-loop/lid; other site
582899005156	ABC transporter signature motif; other site
582899005157	Walker B; other site
582899005158	D-loop; other site
582899005159	H-loop/switch region; other site
582899005160	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
582899005161	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
582899005162	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
582899005163	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
582899005164	Walker A; other site
582899005165	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
582899005166	Switch II region; other site
582899005167	G4 box; other site
582899005168	G5 box; other site
582899005169	amino acid transporter; Region: 2A0306; TIGR00909
582899005170	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
582899005171	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
582899005172	adenylosuccinate lyase; Provisional; Region: PRK07492
582899005173	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
582899005174	tetramer interface [polypeptide binding]; other site
582899005175	active site
582899005176	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
582899005177	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
582899005178	active site
582899005179	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
582899005180	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
582899005181	Ligand binding site; other site
582899005182	Putative Catalytic site; other site
582899005183	DXD motif; other site
582899005184	Predicted membrane protein [Function unknown]; Region: COG2246
582899005185	GtrA-like protein; Region: GtrA; pfam04138
582899005186	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582899005187	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
582899005188	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
582899005189	dimerization interface [polypeptide binding]; other site
582899005190	metal binding site [ion binding]; metal-binding site
582899005191	Serine hydrolase; Region: Ser_hydrolase; pfam06821
582899005192	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899005193	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
582899005194	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
582899005195	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
582899005196	ATP binding site [chemical binding]; other site
582899005197	active site
582899005198	substrate binding site [chemical binding]; other site
582899005199	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
582899005200	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
582899005201	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
582899005202	putative active site [active]
582899005203	catalytic triad [active]
582899005204	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899005205	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
582899005206	ligand binding site [chemical binding]; other site
582899005207	dimer interface [polypeptide binding]; other site
582899005208	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
582899005209	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
582899005210	dimerization interface [polypeptide binding]; other site
582899005211	ATP binding site [chemical binding]; other site
582899005212	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
582899005213	dimerization interface [polypeptide binding]; other site
582899005214	ATP binding site [chemical binding]; other site
582899005215	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
582899005216	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
582899005217	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
582899005218	PqqA family; Region: PqqA; cl15372
582899005219	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
582899005220	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
582899005221	putative GSH binding site [chemical binding]; other site
582899005222	catalytic residues [active]
582899005223	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582899005224	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
582899005225	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899005226	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899005227	Paraquat-inducible protein A; Region: PqiA; pfam04403
582899005228	Paraquat-inducible protein A; Region: PqiA; pfam04403
582899005229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005230	putative substrate translocation pore; other site
582899005231	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
582899005232	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
582899005233	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899005234	RNA binding surface [nucleotide binding]; other site
582899005235	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
582899005236	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
582899005237	isocitrate dehydrogenase; Validated; Region: PRK08299
582899005238	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899005239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899005240	S-adenosylmethionine binding site [chemical binding]; other site
582899005241	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
582899005242	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
582899005243	motif 1; other site
582899005244	active site
582899005245	motif 2; other site
582899005246	motif 3; other site
582899005247	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
582899005248	recombinase A; Provisional; Region: recA; PRK09354
582899005249	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
582899005250	hexamer interface [polypeptide binding]; other site
582899005251	Walker A motif; other site
582899005252	ATP binding site [chemical binding]; other site
582899005253	Walker B motif; other site
582899005254	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
582899005255	PAS domain S-box; Region: sensory_box; TIGR00229
582899005256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899005257	putative active site [active]
582899005258	heme pocket [chemical binding]; other site
582899005259	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582899005260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899005261	dimer interface [polypeptide binding]; other site
582899005262	phosphorylation site [posttranslational modification]
582899005263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899005264	ATP binding site [chemical binding]; other site
582899005265	Mg2+ binding site [ion binding]; other site
582899005266	G-X-G motif; other site
582899005267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899005268	Response regulator receiver domain; Region: Response_reg; pfam00072
582899005269	active site
582899005270	phosphorylation site [posttranslational modification]
582899005271	intermolecular recognition site; other site
582899005272	dimerization interface [polypeptide binding]; other site
582899005273	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
582899005274	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899005275	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
582899005276	Walker A motif; other site
582899005277	ATP binding site [chemical binding]; other site
582899005278	Walker B motif; other site
582899005279	arginine finger; other site
582899005280	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
582899005281	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
582899005282	active site
582899005283	dimer interface [polypeptide binding]; other site
582899005284	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
582899005285	Ligand Binding Site [chemical binding]; other site
582899005286	Molecular Tunnel; other site
582899005287	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899005288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899005289	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
582899005290	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
582899005291	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899005292	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
582899005293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005294	putative substrate translocation pore; other site
582899005295	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
582899005296	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899005297	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
582899005298	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
582899005299	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
582899005300	glutathionine S-transferase; Provisional; Region: PRK10542
582899005301	C-terminal domain interface [polypeptide binding]; other site
582899005302	GSH binding site (G-site) [chemical binding]; other site
582899005303	dimer interface [polypeptide binding]; other site
582899005304	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
582899005305	N-terminal domain interface [polypeptide binding]; other site
582899005306	dimer interface [polypeptide binding]; other site
582899005307	substrate binding pocket (H-site) [chemical binding]; other site
582899005308	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
582899005309	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
582899005310	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
582899005311	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
582899005312	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
582899005313	type II secretion system protein I; Region: gspI; TIGR01707
582899005314	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
582899005315	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
582899005316	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
582899005317	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
582899005318	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
582899005319	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582899005320	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
582899005321	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
582899005322	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
582899005323	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
582899005324	Walker A motif; other site
582899005325	ATP binding site [chemical binding]; other site
582899005326	Walker B motif; other site
582899005327	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582899005328	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582899005329	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582899005330	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
582899005331	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
582899005332	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
582899005333	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
582899005334	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582899005335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899005336	Carboxylesterase family; Region: COesterase; pfam00135
582899005337	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582899005338	substrate binding pocket [chemical binding]; other site
582899005339	catalytic triad [active]
582899005340	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582899005341	Carboxylesterase family; Region: COesterase; pfam00135
582899005342	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
582899005343	substrate binding pocket [chemical binding]; other site
582899005344	catalytic triad [active]
582899005345	Cupin domain; Region: Cupin_2; cl17218
582899005346	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582899005347	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899005348	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
582899005349	catalytic site [active]
582899005350	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899005351	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899005352	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582899005353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582899005354	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
582899005355	catalytic site [active]
582899005356	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
582899005357	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582899005358	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
582899005359	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
582899005360	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
582899005361	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
582899005362	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
582899005363	Protein of unknown function (DUF423); Region: DUF423; cl01008
582899005364	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
582899005365	active site
582899005366	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
582899005367	active site
582899005368	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
582899005369	active site
582899005370	DNA binding site [nucleotide binding]
582899005371	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
582899005372	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
582899005373	active site
582899005374	(T/H)XGH motif; other site
582899005375	PAP2 superfamily; Region: PAP2_3; pfam14378
582899005376	active site
582899005377	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899005378	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
582899005379	ligand binding site [chemical binding]; other site
582899005380	flexible hinge region; other site
582899005381	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
582899005382	putative switch regulator; other site
582899005383	non-specific DNA interactions [nucleotide binding]; other site
582899005384	DNA binding site [nucleotide binding]
582899005385	sequence specific DNA binding site [nucleotide binding]; other site
582899005386	putative cAMP binding site [chemical binding]; other site
582899005387	DNA gyrase, A subunit; Region: gyrA; TIGR01063
582899005388	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
582899005389	CAP-like domain; other site
582899005390	active site
582899005391	primary dimer interface [polypeptide binding]; other site
582899005392	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582899005393	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582899005394	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582899005395	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582899005396	Cytochrome c; Region: Cytochrom_C; cl11414
582899005397	Cation efflux family; Region: Cation_efflux; pfam01545
582899005398	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
582899005399	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
582899005400	dimer interface [polypeptide binding]; other site
582899005401	ssDNA binding site [nucleotide binding]; other site
582899005402	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582899005403	Flagellin N-methylase; Region: FliB; pfam03692
582899005404	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
582899005405	active site
582899005406	metal binding site [ion binding]; metal-binding site
582899005407	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899005408	Uncharacterized conserved protein [Function unknown]; Region: COG3791
582899005409	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
582899005410	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
582899005411	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
582899005412	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
582899005413	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
582899005414	dimer interface [polypeptide binding]; other site
582899005415	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
582899005416	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
582899005417	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899005418	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
582899005419	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
582899005420	PhnA protein; Region: PhnA; pfam03831
582899005421	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
582899005422	active site clefts [active]
582899005423	zinc binding site [ion binding]; other site
582899005424	dimer interface [polypeptide binding]; other site
582899005425	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
582899005426	short chain dehydrogenase; Provisional; Region: PRK06914
582899005427	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
582899005428	NADP binding site [chemical binding]; other site
582899005429	active site
582899005430	steroid binding site; other site
582899005431	Beta-lactamase; Region: Beta-lactamase; pfam00144
582899005432	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
582899005433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005434	putative substrate translocation pore; other site
582899005435	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899005436	TonB C terminal; Region: TonB_2; pfam13103
582899005437	Protein of unknown function DUF72; Region: DUF72; pfam01904
582899005438	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
582899005439	active site 1 [active]
582899005440	active site 2 [active]
582899005441	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
582899005442	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899005443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
582899005444	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
582899005445	DNA photolyase; Region: DNA_photolyase; pfam00875
582899005446	TPR repeat; Region: TPR_11; pfam13414
582899005447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899005448	TPR motif; other site
582899005449	TPR repeat; Region: TPR_11; pfam13414
582899005450	binding surface
582899005451	TPR repeat; Region: TPR_11; pfam13414
582899005452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899005453	binding surface
582899005454	TPR motif; other site
582899005455	TPR repeat; Region: TPR_11; pfam13414
582899005456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899005457	TPR motif; other site
582899005458	binding surface
582899005459	TPR repeat; Region: TPR_11; pfam13414
582899005460	TPR repeat; Region: TPR_11; pfam13414
582899005461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899005462	binding surface
582899005463	TPR motif; other site
582899005464	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
582899005465	active site
582899005466	Uncharacterized conserved protein [Function unknown]; Region: COG0062
582899005467	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
582899005468	putative substrate binding site [chemical binding]; other site
582899005469	putative ATP binding site [chemical binding]; other site
582899005470	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
582899005471	Nitrogen regulatory protein P-II; Region: P-II; smart00938
582899005472	glutamine synthetase; Provisional; Region: glnA; PRK09469
582899005473	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
582899005474	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582899005475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005476	putative substrate translocation pore; other site
582899005477	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
582899005478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899005479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899005480	homodimer interface [polypeptide binding]; other site
582899005481	catalytic residue [active]
582899005482	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
582899005483	Phospholipid methyltransferase; Region: PEMT; pfam04191
582899005484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
582899005485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899005486	Coenzyme A binding pocket [chemical binding]; other site
582899005487	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582899005488	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
582899005489	NodB motif; other site
582899005490	active site
582899005491	catalytic site [active]
582899005492	metal binding site [ion binding]; metal-binding site
582899005493	lipoate-protein ligase B; Provisional; Region: PRK14341
582899005494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899005495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899005496	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899005497	dimerization interface [polypeptide binding]; other site
582899005498	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
582899005499	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582899005500	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
582899005501	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
582899005502	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
582899005503	carboxyltransferase (CT) interaction site; other site
582899005504	biotinylation site [posttranslational modification]; other site
582899005505	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
582899005506	Recombination protein O N terminal; Region: RecO_N; pfam11967
582899005507	Recombination protein O C terminal; Region: RecO_C; pfam02565
582899005508	GTPase Era; Reviewed; Region: era; PRK00089
582899005509	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
582899005510	G1 box; other site
582899005511	GTP/Mg2+ binding site [chemical binding]; other site
582899005512	Switch I region; other site
582899005513	G2 box; other site
582899005514	Switch II region; other site
582899005515	G3 box; other site
582899005516	G4 box; other site
582899005517	G5 box; other site
582899005518	KH domain; Region: KH_2; pfam07650
582899005519	ribonuclease III; Reviewed; Region: rnc; PRK00102
582899005520	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
582899005521	dimerization interface [polypeptide binding]; other site
582899005522	active site
582899005523	metal binding site [ion binding]; metal-binding site
582899005524	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
582899005525	dsRNA binding site [nucleotide binding]; other site
582899005526	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
582899005527	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582899005528	Catalytic site [active]
582899005529	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582899005530	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
582899005531	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
582899005532	active site
582899005533	hydrophilic channel; other site
582899005534	dimerization interface [polypeptide binding]; other site
582899005535	catalytic residues [active]
582899005536	active site lid [active]
582899005537	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
582899005538	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
582899005539	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582899005540	Zn2+ binding site [ion binding]; other site
582899005541	Mg2+ binding site [ion binding]; other site
582899005542	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
582899005543	synthetase active site [active]
582899005544	NTP binding site [chemical binding]; other site
582899005545	metal binding site [ion binding]; metal-binding site
582899005546	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
582899005547	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
582899005548	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
582899005549	Uncharacterized conserved protein [Function unknown]; Region: COG1432
582899005550	LabA_like proteins; Region: LabA; cd10911
582899005551	putative metal binding site [ion binding]; other site
582899005552	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
582899005553	Fe-S cluster binding site [ion binding]; other site
582899005554	DNA binding site [nucleotide binding]
582899005555	active site
582899005556	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
582899005557	catalytic triad [active]
582899005558	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
582899005559	SmpB-tmRNA interface; other site
582899005560	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
582899005561	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
582899005562	dimer interface [polypeptide binding]; other site
582899005563	active site
582899005564	catalytic residue [active]
582899005565	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
582899005566	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
582899005567	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582899005568	catalytic residue [active]
582899005569	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899005570	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899005571	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582899005572	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582899005573	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899005574	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582899005575	ligand binding site [chemical binding]; other site
582899005576	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
582899005577	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
582899005578	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
582899005579	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
582899005580	Cytochrome c; Region: Cytochrom_C; pfam00034
582899005581	CsbD-like; Region: CsbD; cl17424
582899005582	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899005583	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
582899005584	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899005585	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
582899005586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005587	putative substrate translocation pore; other site
582899005588	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899005589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899005590	active site
582899005591	phosphorylation site [posttranslational modification]
582899005592	intermolecular recognition site; other site
582899005593	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899005594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899005595	active site
582899005596	phosphorylation site [posttranslational modification]
582899005597	intermolecular recognition site; other site
582899005598	dimerization interface [polypeptide binding]; other site
582899005599	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899005600	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899005601	ligand binding site [chemical binding]; other site
582899005602	flexible hinge region; other site
582899005603	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
582899005604	putative switch regulator; other site
582899005605	non-specific DNA interactions [nucleotide binding]; other site
582899005606	DNA binding site [nucleotide binding]
582899005607	sequence specific DNA binding site [nucleotide binding]; other site
582899005608	putative cAMP binding site [chemical binding]; other site
582899005609	NnrS protein; Region: NnrS; pfam05940
582899005610	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
582899005611	putative deacylase active site [active]
582899005612	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
582899005613	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
582899005614	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
582899005615	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
582899005616	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
582899005617	HD domain; Region: HD_4; pfam13328
582899005618	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
582899005619	putative acyl-acceptor binding pocket; other site
582899005620	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
582899005621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899005622	S-adenosylmethionine binding site [chemical binding]; other site
582899005623	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
582899005624	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
582899005625	DXD motif; other site
582899005626	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
582899005627	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
582899005628	substrate binding pocket [chemical binding]; other site
582899005629	membrane-bound complex binding site; other site
582899005630	hinge residues; other site
582899005631	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
582899005632	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582899005633	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
582899005634	putative active site [active]
582899005635	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
582899005636	GIY-YIG motif/motif A; other site
582899005637	putative active site [active]
582899005638	putative metal binding site [ion binding]; other site
582899005639	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
582899005640	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
582899005641	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899005642	catalytic residues [active]
582899005643	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582899005644	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899005645	active site
582899005646	Dienelactone hydrolase family; Region: DLH; pfam01738
582899005647	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
582899005648	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
582899005649	active site
582899005650	substrate-binding site [chemical binding]; other site
582899005651	metal-binding site [ion binding]
582899005652	ATP binding site [chemical binding]; other site
582899005653	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899005654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899005655	active site
582899005656	phosphorylation site [posttranslational modification]
582899005657	intermolecular recognition site; other site
582899005658	dimerization interface [polypeptide binding]; other site
582899005659	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899005660	DNA binding site [nucleotide binding]
582899005661	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
582899005662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899005663	HAMP domain; Region: HAMP; pfam00672
582899005664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899005665	dimer interface [polypeptide binding]; other site
582899005666	phosphorylation site [posttranslational modification]
582899005667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899005668	ATP binding site [chemical binding]; other site
582899005669	Mg2+ binding site [ion binding]; other site
582899005670	G-X-G motif; other site
582899005671	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
582899005672	Hpr binding site; other site
582899005673	active site
582899005674	homohexamer subunit interaction site [polypeptide binding]; other site
582899005675	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
582899005676	active pocket/dimerization site; other site
582899005677	active site
582899005678	phosphorylation site [posttranslational modification]
582899005679	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
582899005680	dimerization domain swap beta strand [polypeptide binding]; other site
582899005681	regulatory protein interface [polypeptide binding]; other site
582899005682	active site
582899005683	regulatory phosphorylation site [posttranslational modification]; other site
582899005684	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
582899005685	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
582899005686	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582899005687	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582899005688	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
582899005689	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
582899005690	homotetramer interface [polypeptide binding]; other site
582899005691	ligand binding site [chemical binding]; other site
582899005692	catalytic site [active]
582899005693	NAD binding site [chemical binding]; other site
582899005694	PAS fold; Region: PAS_7; pfam12860
582899005695	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899005696	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899005697	dimer interface [polypeptide binding]; other site
582899005698	phosphorylation site [posttranslational modification]
582899005699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899005700	ATP binding site [chemical binding]; other site
582899005701	Mg2+ binding site [ion binding]; other site
582899005702	G-X-G motif; other site
582899005703	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
582899005704	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
582899005705	Phosphotransferase enzyme family; Region: APH; pfam01636
582899005706	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
582899005707	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
582899005708	Substrate binding site; other site
582899005709	metal-binding site
582899005710	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
582899005711	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
582899005712	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
582899005713	Family description; Region: UvrD_C_2; pfam13538
582899005714	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
582899005715	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582899005716	catalytic residues [active]
582899005717	Isochorismatase family; Region: Isochorismatase; pfam00857
582899005718	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
582899005719	catalytic triad [active]
582899005720	conserved cis-peptide bond; other site
582899005721	Protein of unknown function (DUF779); Region: DUF779; pfam05610
582899005722	Protein of unknown function (DUF779); Region: DUF779; cl01432
582899005723	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
582899005724	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582899005725	NAD(P) binding site [chemical binding]; other site
582899005726	catalytic residues [active]
582899005727	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
582899005728	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
582899005729	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
582899005730	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
582899005731	substrate binding site [chemical binding]; other site
582899005732	active site
582899005733	catalytic residues [active]
582899005734	heterodimer interface [polypeptide binding]; other site
582899005735	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
582899005736	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
582899005737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899005738	catalytic residue [active]
582899005739	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
582899005740	active site
582899005741	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
582899005742	IHF dimer interface [polypeptide binding]; other site
582899005743	IHF - DNA interface [nucleotide binding]; other site
582899005744	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
582899005745	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
582899005746	tandem repeat interface [polypeptide binding]; other site
582899005747	oligomer interface [polypeptide binding]; other site
582899005748	active site residues [active]
582899005749	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
582899005750	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
582899005751	RNA binding site [nucleotide binding]; other site
582899005752	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
582899005753	RNA binding site [nucleotide binding]; other site
582899005754	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
582899005755	RNA binding site [nucleotide binding]; other site
582899005756	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
582899005757	RNA binding site [nucleotide binding]; other site
582899005758	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
582899005759	RNA binding site [nucleotide binding]; other site
582899005760	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
582899005761	RNA binding site [nucleotide binding]; other site
582899005762	cytidylate kinase; Provisional; Region: cmk; PRK00023
582899005763	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
582899005764	CMP-binding site; other site
582899005765	The sites determining sugar specificity; other site
582899005766	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
582899005767	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
582899005768	hinge; other site
582899005769	active site
582899005770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
582899005771	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
582899005772	GIY-YIG motif/motif A; other site
582899005773	putative active site [active]
582899005774	putative metal binding site [ion binding]; other site
582899005775	carbon starvation protein A; Provisional; Region: PRK15015
582899005776	Carbon starvation protein CstA; Region: CstA; pfam02554
582899005777	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
582899005778	Protein of unknown function (DUF466); Region: DUF466; pfam04328
582899005779	ABC transporter ATPase component; Reviewed; Region: PRK11147
582899005780	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899005781	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899005782	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
582899005783	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
582899005784	putative dimer interface [polypeptide binding]; other site
582899005785	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
582899005786	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
582899005787	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
582899005788	putative NAD(P) binding site [chemical binding]; other site
582899005789	active site
582899005790	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899005791	dimerization interface [polypeptide binding]; other site
582899005792	putative DNA binding site [nucleotide binding]; other site
582899005793	putative Zn2+ binding site [ion binding]; other site
582899005794	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
582899005795	Low molecular weight phosphatase family; Region: LMWPc; cd00115
582899005796	active site
582899005797	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
582899005798	arsenical-resistance protein; Region: acr3; TIGR00832
582899005799	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
582899005800	ArsC family; Region: ArsC; pfam03960
582899005801	catalytic residues [active]
582899005802	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
582899005803	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582899005804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899005805	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582899005806	putative substrate translocation pore; other site
582899005807	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
582899005808	Proline dehydrogenase; Region: Pro_dh; pfam01619
582899005809	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
582899005810	Glutamate binding site [chemical binding]; other site
582899005811	NAD binding site [chemical binding]; other site
582899005812	catalytic residues [active]
582899005813	pantoate--beta-alanine ligase; Region: panC; TIGR00018
582899005814	Pantoate-beta-alanine ligase; Region: PanC; cd00560
582899005815	active site
582899005816	ATP-binding site [chemical binding]; other site
582899005817	pantoate-binding site; other site
582899005818	HXXH motif; other site
582899005819	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
582899005820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899005821	Mg2+ binding site [ion binding]; other site
582899005822	G-X-G motif; other site
582899005823	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
582899005824	anchoring element; other site
582899005825	dimer interface [polypeptide binding]; other site
582899005826	ATP binding site [chemical binding]; other site
582899005827	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
582899005828	active site
582899005829	putative metal-binding site [ion binding]; other site
582899005830	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
582899005831	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
582899005832	Fatty acid desaturase; Region: FA_desaturase; pfam00487
582899005833	putative di-iron ligands [ion binding]; other site
582899005834	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
582899005835	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
582899005836	amphipathic channel; other site
582899005837	Asn-Pro-Ala signature motifs; other site
582899005838	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
582899005839	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
582899005840	ATP binding site [chemical binding]; other site
582899005841	Mg++ binding site [ion binding]; other site
582899005842	motif III; other site
582899005843	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899005844	nucleotide binding region [chemical binding]; other site
582899005845	ATP-binding site [chemical binding]; other site
582899005846	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
582899005847	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
582899005848	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582899005849	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
582899005850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899005851	catalytic residue [active]
582899005852	FeS assembly protein SufD; Region: sufD; TIGR01981
582899005853	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
582899005854	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
582899005855	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
582899005856	Walker A/P-loop; other site
582899005857	ATP binding site [chemical binding]; other site
582899005858	Q-loop/lid; other site
582899005859	ABC transporter signature motif; other site
582899005860	Walker B; other site
582899005861	D-loop; other site
582899005862	H-loop/switch region; other site
582899005863	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
582899005864	putative ABC transporter; Region: ycf24; CHL00085
582899005865	Transcriptional regulator; Region: Rrf2; cl17282
582899005866	Rrf2 family protein; Region: rrf2_super; TIGR00738
582899005867	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
582899005868	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
582899005869	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899005870	catalytic residue [active]
582899005871	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
582899005872	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
582899005873	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
582899005874	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
582899005875	active site
582899005876	HIGH motif; other site
582899005877	dimer interface [polypeptide binding]; other site
582899005878	KMSKS motif; other site
582899005879	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899005880	RNA binding surface [nucleotide binding]; other site
582899005881	Protein of unknown function; Region: DUF3971; pfam13116
582899005882	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
582899005883	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
582899005884	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
582899005885	catalytic triad [active]
582899005886	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582899005887	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582899005888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899005889	Coenzyme A binding pocket [chemical binding]; other site
582899005890	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
582899005891	Usg-like family; Region: Usg; cl11567
582899005892	RNA polymerase sigma factor; Provisional; Region: PRK11922
582899005893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899005894	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899005895	DNA binding residues [nucleotide binding]
582899005896	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
582899005897	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
582899005898	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
582899005899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899005900	Histidine kinase; Region: HisKA_2; pfam07568
582899005901	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
582899005902	ATP binding site [chemical binding]; other site
582899005903	Mg2+ binding site [ion binding]; other site
582899005904	G-X-G motif; other site
582899005905	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
582899005906	DNA-binding site [nucleotide binding]; DNA binding site
582899005907	RNA-binding motif; other site
582899005908	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
582899005909	MoxR-like ATPases [General function prediction only]; Region: COG0714
582899005910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899005911	Walker A motif; other site
582899005912	ATP binding site [chemical binding]; other site
582899005913	Walker B motif; other site
582899005914	arginine finger; other site
582899005915	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582899005916	Protein of unknown function DUF58; Region: DUF58; pfam01882
582899005917	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
582899005918	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
582899005919	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
582899005920	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
582899005921	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
582899005922	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
582899005923	Zn binding site [ion binding]; other site
582899005924	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
582899005925	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
582899005926	ThiC-associated domain; Region: ThiC-associated; pfam13667
582899005927	ThiC family; Region: ThiC; pfam01964
582899005928	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582899005929	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
582899005930	NodB motif; other site
582899005931	active site
582899005932	catalytic site [active]
582899005933	metal binding site [ion binding]; metal-binding site
582899005934	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582899005935	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
582899005936	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
582899005937	Cl binding site [ion binding]; other site
582899005938	oligomer interface [polypeptide binding]; other site
582899005939	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
582899005940	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
582899005941	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
582899005942	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
582899005943	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
582899005944	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582899005945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899005946	non-specific DNA binding site [nucleotide binding]; other site
582899005947	salt bridge; other site
582899005948	sequence-specific DNA binding site [nucleotide binding]; other site
582899005949	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899005950	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582899005951	active site
582899005952	nucleophile elbow; other site
582899005953	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
582899005954	putative active site [active]
582899005955	putative metal binding site [ion binding]; other site
582899005956	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582899005957	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
582899005958	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
582899005959	nudix motif; other site
582899005960	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582899005961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899005962	Coenzyme A binding pocket [chemical binding]; other site
582899005963	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005964	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005965	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005966	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005967	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005968	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
582899005969	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
582899005970	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
582899005971	NodB motif; other site
582899005972	active site
582899005973	catalytic site [active]
582899005974	metal binding site [ion binding]; metal-binding site
582899005975	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
582899005976	nudix motif; other site
582899005977	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
582899005978	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
582899005979	GDP-binding site [chemical binding]; other site
582899005980	ACT binding site; other site
582899005981	IMP binding site; other site
582899005982	conserved hypothetical protein; Region: TIGR02231
582899005983	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
582899005984	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
582899005985	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
582899005986	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
582899005987	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899005988	catalytic residue [active]
582899005989	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899005990	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
582899005991	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
582899005992	active site
582899005993	substrate binding site [chemical binding]; other site
582899005994	metal binding site [ion binding]; metal-binding site
582899005995	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582899005996	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899005997	P-loop; other site
582899005998	Magnesium ion binding site [ion binding]; other site
582899005999	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899006000	Magnesium ion binding site [ion binding]; other site
582899006001	amino acid transporter; Region: 2A0306; TIGR00909
582899006002	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582899006003	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
582899006004	dihydropteroate synthase; Region: DHPS; TIGR01496
582899006005	substrate binding pocket [chemical binding]; other site
582899006006	dimer interface [polypeptide binding]; other site
582899006007	inhibitor binding site; inhibition site
582899006008	FtsH Extracellular; Region: FtsH_ext; pfam06480
582899006009	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
582899006010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899006011	Walker A motif; other site
582899006012	ATP binding site [chemical binding]; other site
582899006013	Walker B motif; other site
582899006014	arginine finger; other site
582899006015	Peptidase family M41; Region: Peptidase_M41; pfam01434
582899006016	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
582899006017	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
582899006018	Ligand Binding Site [chemical binding]; other site
582899006019	Cyclin-dependent kinase 5 activator protein; Region: CDK5_activator; pfam03261
582899006020	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
582899006021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899006022	binding surface
582899006023	TPR motif; other site
582899006024	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582899006025	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899006026	ligand binding site [chemical binding]; other site
582899006027	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
582899006028	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899006029	ligand binding site [chemical binding]; other site
582899006030	translocation protein TolB; Provisional; Region: tolB; PRK05137
582899006031	TolB amino-terminal domain; Region: TolB_N; pfam04052
582899006032	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582899006033	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582899006034	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
582899006035	TolR protein; Region: tolR; TIGR02801
582899006036	TolQ protein; Region: tolQ; TIGR02796
582899006037	TIGR03663 family protein; Region: TIGR03663
582899006038	ethanolamine permease; Region: 2A0305; TIGR00908
582899006039	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
582899006040	active site
582899006041	phosphodiesterase YaeI; Provisional; Region: PRK11340
582899006042	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
582899006043	putative active site [active]
582899006044	putative metal binding site [ion binding]; other site
582899006045	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
582899006046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899006047	Walker A motif; other site
582899006048	ATP binding site [chemical binding]; other site
582899006049	Walker B motif; other site
582899006050	arginine finger; other site
582899006051	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
582899006052	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
582899006053	RuvA N terminal domain; Region: RuvA_N; pfam01330
582899006054	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
582899006055	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
582899006056	active site
582899006057	putative DNA-binding cleft [nucleotide binding]; other site
582899006058	dimer interface [polypeptide binding]; other site
582899006059	hypothetical protein; Validated; Region: PRK00110
582899006060	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
582899006061	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582899006062	putative active site [active]
582899006063	metal binding site [ion binding]; metal-binding site
582899006064	homodimer binding site [polypeptide binding]; other site
582899006065	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
582899006066	Cell division protein ZapA; Region: ZapA; pfam05164
582899006067	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
582899006068	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
582899006069	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
582899006070	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
582899006071	active site
582899006072	intersubunit interface [polypeptide binding]; other site
582899006073	catalytic residue [active]
582899006074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
582899006075	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899006076	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899006077	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
582899006078	thiamine phosphate binding site [chemical binding]; other site
582899006079	active site
582899006080	pyrophosphate binding site [ion binding]; other site
582899006081	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582899006082	Sel1-like repeats; Region: SEL1; smart00671
582899006083	Sel1-like repeats; Region: SEL1; smart00671
582899006084	Sel1-like repeats; Region: SEL1; smart00671
582899006085	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582899006086	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
582899006087	active site
582899006088	dimerization interface [polypeptide binding]; other site
582899006089	hypothetical protein; Validated; Region: PRK09039
582899006090	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899006091	ligand binding site [chemical binding]; other site
582899006092	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
582899006093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582899006094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899006095	Walker A/P-loop; other site
582899006096	ATP binding site [chemical binding]; other site
582899006097	Q-loop/lid; other site
582899006098	ABC transporter signature motif; other site
582899006099	Walker B; other site
582899006100	D-loop; other site
582899006101	H-loop/switch region; other site
582899006102	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
582899006103	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
582899006104	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
582899006105	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
582899006106	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
582899006107	NAD(P) binding site [chemical binding]; other site
582899006108	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
582899006109	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
582899006110	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899006111	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899006112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899006113	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
582899006114	NAD(P) binding site [chemical binding]; other site
582899006115	active site
582899006116	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899006117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899006118	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899006119	dimerization interface [polypeptide binding]; other site
582899006120	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
582899006121	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
582899006122	putative dimer interface [polypeptide binding]; other site
582899006123	[2Fe-2S] cluster binding site [ion binding]; other site
582899006124	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
582899006125	putative dimer interface [polypeptide binding]; other site
582899006126	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
582899006127	SLBB domain; Region: SLBB; pfam10531
582899006128	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
582899006129	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
582899006130	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
582899006131	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582899006132	catalytic loop [active]
582899006133	iron binding site [ion binding]; other site
582899006134	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
582899006135	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
582899006136	[4Fe-4S] binding site [ion binding]; other site
582899006137	molybdopterin cofactor binding site; other site
582899006138	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
582899006139	molybdopterin cofactor binding site; other site
582899006140	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
582899006141	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
582899006142	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
582899006143	elongation factor G; Reviewed; Region: PRK12740
582899006144	G1 box; other site
582899006145	putative GEF interaction site [polypeptide binding]; other site
582899006146	GTP/Mg2+ binding site [chemical binding]; other site
582899006147	Switch I region; other site
582899006148	G2 box; other site
582899006149	G3 box; other site
582899006150	Switch II region; other site
582899006151	G4 box; other site
582899006152	G5 box; other site
582899006153	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
582899006154	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
582899006155	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
582899006156	aspartate aminotransferase; Provisional; Region: PRK05764
582899006157	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899006158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899006159	homodimer interface [polypeptide binding]; other site
582899006160	catalytic residue [active]
582899006161	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
582899006162	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899006163	NAD(P) binding site [chemical binding]; other site
582899006164	active site
582899006165	excinuclease ABC subunit B; Provisional; Region: PRK05298
582899006166	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899006167	ATP binding site [chemical binding]; other site
582899006168	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899006169	nucleotide binding region [chemical binding]; other site
582899006170	ATP-binding site [chemical binding]; other site
582899006171	Ultra-violet resistance protein B; Region: UvrB; pfam12344
582899006172	UvrB/uvrC motif; Region: UVR; pfam02151
582899006173	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
582899006174	intracellular protease, PfpI family; Region: PfpI; TIGR01382
582899006175	proposed catalytic triad [active]
582899006176	conserved cys residue [active]
582899006177	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
582899006178	catalytic core [active]
582899006179	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582899006180	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
582899006181	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899006182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899006183	active site
582899006184	phosphorylation site [posttranslational modification]
582899006185	intermolecular recognition site; other site
582899006186	dimerization interface [polypeptide binding]; other site
582899006187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899006188	DNA binding site [nucleotide binding]
582899006189	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
582899006190	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
582899006191	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
582899006192	Ligand Binding Site [chemical binding]; other site
582899006193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899006194	S-adenosylmethionine binding site [chemical binding]; other site
582899006195	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
582899006196	hypothetical protein; Provisional; Region: PRK09256
582899006197	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
582899006198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
582899006199	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
582899006200	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
582899006201	homodimer interface [polypeptide binding]; other site
582899006202	substrate-cofactor binding pocket; other site
582899006203	catalytic residue [active]
582899006204	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582899006205	MarR family; Region: MarR_2; pfam12802
582899006206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899006207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899006208	active site
582899006209	phosphorylation site [posttranslational modification]
582899006210	intermolecular recognition site; other site
582899006211	dimerization interface [polypeptide binding]; other site
582899006212	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899006213	DNA binding site [nucleotide binding]
582899006214	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899006215	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
582899006216	dimerization interface [polypeptide binding]; other site
582899006217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899006218	dimer interface [polypeptide binding]; other site
582899006219	phosphorylation site [posttranslational modification]
582899006220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899006221	ATP binding site [chemical binding]; other site
582899006222	Mg2+ binding site [ion binding]; other site
582899006223	G-X-G motif; other site
582899006224	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
582899006225	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
582899006226	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
582899006227	Membrane fusogenic activity; Region: BMFP; pfam04380
582899006228	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
582899006229	Uncharacterized conserved protein [Function unknown]; Region: COG1565
582899006230	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
582899006231	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
582899006232	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
582899006233	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
582899006234	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899006235	active site
582899006236	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
582899006237	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
582899006238	putative NAD(P) binding site [chemical binding]; other site
582899006239	putative substrate binding site [chemical binding]; other site
582899006240	catalytic Zn binding site [ion binding]; other site
582899006241	structural Zn binding site [ion binding]; other site
582899006242	dimer interface [polypeptide binding]; other site
582899006243	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582899006244	metal binding site 2 [ion binding]; metal-binding site
582899006245	putative DNA binding helix; other site
582899006246	metal binding site 1 [ion binding]; metal-binding site
582899006247	dimer interface [polypeptide binding]; other site
582899006248	structural Zn2+ binding site [ion binding]; other site
582899006249	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
582899006250	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
582899006251	5S rRNA interface [nucleotide binding]; other site
582899006252	CTC domain interface [polypeptide binding]; other site
582899006253	L16 interface [polypeptide binding]; other site
582899006254	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
582899006255	putative active site [active]
582899006256	catalytic residue [active]
582899006257	GTP-binding protein YchF; Reviewed; Region: PRK09601
582899006258	YchF GTPase; Region: YchF; cd01900
582899006259	G1 box; other site
582899006260	GTP/Mg2+ binding site [chemical binding]; other site
582899006261	Switch I region; other site
582899006262	G2 box; other site
582899006263	Switch II region; other site
582899006264	G3 box; other site
582899006265	G4 box; other site
582899006266	G5 box; other site
582899006267	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
582899006268	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
582899006269	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
582899006270	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
582899006271	tetramer interface [polypeptide binding]; other site
582899006272	heme binding pocket [chemical binding]; other site
582899006273	NADPH binding site [chemical binding]; other site
582899006274	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
582899006275	intersubunit interface [polypeptide binding]; other site
582899006276	active site
582899006277	Zn2+ binding site [ion binding]; other site
582899006278	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
582899006279	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
582899006280	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899006281	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899006282	active site
582899006283	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
582899006284	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
582899006285	cytochrome b; Provisional; Region: CYTB; MTH00191
582899006286	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
582899006287	intrachain domain interface; other site
582899006288	Qi binding site; other site
582899006289	interchain domain interface [polypeptide binding]; other site
582899006290	heme bH binding site [chemical binding]; other site
582899006291	heme bL binding site [chemical binding]; other site
582899006292	Qo binding site; other site
582899006293	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
582899006294	interchain domain interface [polypeptide binding]; other site
582899006295	intrachain domain interface; other site
582899006296	Qi binding site; other site
582899006297	Qo binding site; other site
582899006298	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
582899006299	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
582899006300	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
582899006301	[2Fe-2S] cluster binding site [ion binding]; other site
582899006302	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
582899006303	Phospholipid methyltransferase; Region: PEMT; cl17370
582899006304	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582899006305	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
582899006306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899006307	Walker A/P-loop; other site
582899006308	ATP binding site [chemical binding]; other site
582899006309	Q-loop/lid; other site
582899006310	ABC transporter signature motif; other site
582899006311	Walker B; other site
582899006312	D-loop; other site
582899006313	H-loop/switch region; other site
582899006314	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
582899006315	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
582899006316	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
582899006317	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
582899006318	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
582899006319	FMN binding site [chemical binding]; other site
582899006320	active site
582899006321	substrate binding site [chemical binding]; other site
582899006322	catalytic residue [active]
582899006323	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
582899006324	putative active site [active]
582899006325	putative CoA binding site [chemical binding]; other site
582899006326	nudix motif; other site
582899006327	metal binding site [ion binding]; metal-binding site
582899006328	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
582899006329	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
582899006330	active site
582899006331	NTP binding site [chemical binding]; other site
582899006332	metal binding triad [ion binding]; metal-binding site
582899006333	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
582899006334	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582899006335	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
582899006336	putative active site [active]
582899006337	putative metal binding site [ion binding]; other site
582899006338	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
582899006339	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899006340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899006341	S-adenosylmethionine binding site [chemical binding]; other site
582899006342	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
582899006343	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
582899006344	ring oligomerisation interface [polypeptide binding]; other site
582899006345	ATP/Mg binding site [chemical binding]; other site
582899006346	stacking interactions; other site
582899006347	hinge regions; other site
582899006348	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
582899006349	oligomerisation interface [polypeptide binding]; other site
582899006350	mobile loop; other site
582899006351	roof hairpin; other site
582899006352	H-NS histone family; Region: Histone_HNS; pfam00816
582899006353	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
582899006354	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
582899006355	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
582899006356	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
582899006357	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899006358	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899006359	ligand binding site [chemical binding]; other site
582899006360	flexible hinge region; other site
582899006361	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
582899006362	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899006363	active site
582899006364	nucleophile elbow; other site
582899006365	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582899006366	nucleophile elbow; other site
582899006367	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
582899006368	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
582899006369	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
582899006370	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
582899006371	heterodimer interface [polypeptide binding]; other site
582899006372	substrate interaction site [chemical binding]; other site
582899006373	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
582899006374	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
582899006375	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
582899006376	putative ion selectivity filter; other site
582899006377	putative pore gating glutamate residue; other site
582899006378	putative H+/Cl- coupling transport residue; other site
582899006379	Protein of unknown function (DUF817); Region: DUF817; pfam05675
582899006380	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
582899006381	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
582899006382	active site
582899006383	substrate binding site [chemical binding]; other site
582899006384	coenzyme B12 binding site [chemical binding]; other site
582899006385	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
582899006386	B12 binding site [chemical binding]; other site
582899006387	cobalt ligand [ion binding]; other site
582899006388	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
582899006389	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
582899006390	ATP binding site [chemical binding]; other site
582899006391	Mg++ binding site [ion binding]; other site
582899006392	motif III; other site
582899006393	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899006394	nucleotide binding region [chemical binding]; other site
582899006395	ATP-binding site [chemical binding]; other site
582899006396	nitrosocyanin; Region: nitroso_cyanin; TIGR03096
582899006397	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
582899006398	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
582899006399	Putative serine esterase (DUF676); Region: DUF676; pfam05057
582899006400	membrane ATPase/protein kinase; Provisional; Region: PRK09435
582899006401	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
582899006402	Walker A; other site
582899006403	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
582899006404	putative substrate binding pocket [chemical binding]; other site
582899006405	AC domain interface; other site
582899006406	catalytic triad [active]
582899006407	AB domain interface; other site
582899006408	Right handed beta helix region; Region: Beta_helix; pfam13229
582899006409	Right handed beta helix region; Region: Beta_helix; pfam13229
582899006410	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
582899006411	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
582899006412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899006413	ATP binding site [chemical binding]; other site
582899006414	putative Mg++ binding site [ion binding]; other site
582899006415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899006416	nucleotide binding region [chemical binding]; other site
582899006417	ATP-binding site [chemical binding]; other site
582899006418	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
582899006419	HRDC domain; Region: HRDC; pfam00570
582899006420	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
582899006421	ATP phosphoribosyltransferase; Region: HisG; cl15266
582899006422	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582899006423	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
582899006424	motif 1; other site
582899006425	dimer interface [polypeptide binding]; other site
582899006426	active site
582899006427	motif 2; other site
582899006428	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582899006429	active site
582899006430	motif 3; other site
582899006431	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
582899006432	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
582899006433	dimer interface [polypeptide binding]; other site
582899006434	motif 1; other site
582899006435	motif 2; other site
582899006436	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582899006437	active site
582899006438	motif 3; other site
582899006439	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
582899006440	anticodon binding site; other site
582899006441	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
582899006442	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
582899006443	cobalamin synthase; Reviewed; Region: cobS; PRK00235
582899006444	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
582899006445	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
582899006446	putative dimer interface [polypeptide binding]; other site
582899006447	active site pocket [active]
582899006448	putative cataytic base [active]
582899006449	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
582899006450	Cysteine-rich domain; Region: CCG; pfam02754
582899006451	Cysteine-rich domain; Region: CCG; pfam02754
582899006452	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
582899006453	FAD binding domain; Region: FAD_binding_4; pfam01565
582899006454	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
582899006455	FAD binding domain; Region: FAD_binding_4; pfam01565
582899006456	glutamate--cysteine ligase; Region: PLN02611
582899006457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
582899006458	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
582899006459	UbiA prenyltransferase family; Region: UbiA; pfam01040
582899006460	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
582899006461	Putative phosphatase (DUF442); Region: DUF442; cl17385
582899006462	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
582899006463	putative acyl-acceptor binding pocket; other site
582899006464	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
582899006465	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
582899006466	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
582899006467	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
582899006468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
582899006469	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
582899006470	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
582899006471	generic binding surface II; other site
582899006472	generic binding surface I; other site
582899006473	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
582899006474	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
582899006475	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
582899006476	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
582899006477	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899006478	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582899006479	nucleophile elbow; other site
582899006480	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
582899006481	nucleoside/Zn binding site; other site
582899006482	dimer interface [polypeptide binding]; other site
582899006483	catalytic motif [active]
582899006484	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582899006485	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899006486	RNA binding surface [nucleotide binding]; other site
582899006487	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
582899006488	active site
582899006489	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
582899006490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899006491	S-adenosylmethionine binding site [chemical binding]; other site
582899006492	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899006493	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899006494	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
582899006495	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
582899006496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899006497	putative substrate translocation pore; other site
582899006498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899006499	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
582899006500	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
582899006501	heme binding site [chemical binding]; other site
582899006502	ferroxidase pore; other site
582899006503	ferroxidase diiron center [ion binding]; other site
582899006504	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
582899006505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899006506	ATP binding site [chemical binding]; other site
582899006507	Mg2+ binding site [ion binding]; other site
582899006508	G-X-G motif; other site
582899006509	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
582899006510	ATP binding site [chemical binding]; other site
582899006511	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
582899006512	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
582899006513	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
582899006514	dimer interface [polypeptide binding]; other site
582899006515	active site
582899006516	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582899006517	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582899006518	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582899006519	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582899006520	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582899006521	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582899006522	lipoprotein signal peptidase; Provisional; Region: PRK14796
582899006523	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
582899006524	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899006525	active site
582899006526	HIGH motif; other site
582899006527	nucleotide binding site [chemical binding]; other site
582899006528	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
582899006529	active site
582899006530	KMSKS motif; other site
582899006531	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
582899006532	tRNA binding surface [nucleotide binding]; other site
582899006533	anticodon binding site; other site
582899006534	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
582899006535	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
582899006536	active site
582899006537	Riboflavin kinase; Region: Flavokinase; pfam01687
582899006538	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
582899006539	dimer interaction site [polypeptide binding]; other site
582899006540	substrate-binding tunnel; other site
582899006541	active site
582899006542	catalytic site [active]
582899006543	substrate binding site [chemical binding]; other site
582899006544	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
582899006545	putative transporter; Provisional; Region: PRK11660
582899006546	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
582899006547	Sulfate transporter family; Region: Sulfate_transp; pfam00916
582899006548	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
582899006549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899006550	non-specific DNA binding site [nucleotide binding]; other site
582899006551	salt bridge; other site
582899006552	sequence-specific DNA binding site [nucleotide binding]; other site
582899006553	acyl-CoA synthetase; Validated; Region: PRK08162
582899006554	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
582899006555	acyl-activating enzyme (AAE) consensus motif; other site
582899006556	putative active site [active]
582899006557	AMP binding site [chemical binding]; other site
582899006558	putative CoA binding site [chemical binding]; other site
582899006559	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
582899006560	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
582899006561	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
582899006562	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
582899006563	putative heme binding pocket [chemical binding]; other site
582899006564	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
582899006565	putative hydrophobic ligand binding site [chemical binding]; other site
582899006566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899006567	dimerization interface [polypeptide binding]; other site
582899006568	putative DNA binding site [nucleotide binding]; other site
582899006569	putative Zn2+ binding site [ion binding]; other site
582899006570	Uncharacterized small protein [Function unknown]; Region: COG5570
582899006571	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
582899006572	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
582899006573	ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793
582899006574	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
582899006575	active site
582899006576	DNA binding site [nucleotide binding]
582899006577	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
582899006578	DNA binding site [nucleotide binding]
582899006579	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
582899006580	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
582899006581	ATP-grasp domain; Region: ATP-grasp; pfam02222
582899006582	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
582899006583	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899006584	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582899006585	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
582899006586	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
582899006587	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
582899006588	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
582899006589	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
582899006590	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
582899006591	ligand binding site [chemical binding]; other site
582899006592	homodimer interface [polypeptide binding]; other site
582899006593	NAD(P) binding site [chemical binding]; other site
582899006594	trimer interface B [polypeptide binding]; other site
582899006595	trimer interface A [polypeptide binding]; other site
582899006596	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
582899006597	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
582899006598	potassium uptake protein; Region: kup; TIGR00794
582899006599	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
582899006600	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
582899006601	active site
582899006602	Zn binding site [ion binding]; other site
582899006603	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582899006604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899006605	active site
582899006606	phosphorylation site [posttranslational modification]
582899006607	intermolecular recognition site; other site
582899006608	dimerization interface [polypeptide binding]; other site
582899006609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899006610	Walker A motif; other site
582899006611	ATP binding site [chemical binding]; other site
582899006612	Walker B motif; other site
582899006613	arginine finger; other site
582899006614	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
582899006615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
582899006616	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899006617	Peptidase M15; Region: Peptidase_M15_3; cl01194
582899006618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
582899006619	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
582899006620	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899006621	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
582899006622	dimerization interface [polypeptide binding]; other site
582899006623	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
582899006624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
582899006625	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
582899006626	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
582899006627	MOFRL family; Region: MOFRL; pfam05161
582899006628	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
582899006629	pyruvate kinase; Provisional; Region: PRK06247
582899006630	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
582899006631	domain interfaces; other site
582899006632	active site
582899006633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899006634	TPR repeat; Region: TPR_11; pfam13414
582899006635	binding surface
582899006636	TPR motif; other site
582899006637	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
582899006638	Response regulator receiver domain; Region: Response_reg; pfam00072
582899006639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899006640	active site
582899006641	phosphorylation site [posttranslational modification]
582899006642	intermolecular recognition site; other site
582899006643	dimerization interface [polypeptide binding]; other site
582899006644	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
582899006645	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
582899006646	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
582899006647	active site
582899006648	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
582899006649	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
582899006650	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
582899006651	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
582899006652	putative dimer interface [polypeptide binding]; other site
582899006653	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
582899006654	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
582899006655	active site
582899006656	dimer interface [polypeptide binding]; other site
582899006657	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
582899006658	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
582899006659	active site
582899006660	FMN binding site [chemical binding]; other site
582899006661	substrate binding site [chemical binding]; other site
582899006662	3Fe-4S cluster binding site [ion binding]; other site
582899006663	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
582899006664	domain interface; other site
582899006665	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
582899006666	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
582899006667	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
582899006668	active site
582899006669	catalytic triad [active]
582899006670	oxyanion hole [active]
582899006671	Transglycosylase SLT domain; Region: SLT_2; pfam13406
582899006672	murein hydrolase B; Provisional; Region: PRK10760; cl17906
582899006673	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
582899006674	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
582899006675	active site
582899006676	tetramer interface; other site
582899006677	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
582899006678	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
582899006679	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
582899006680	putative active site [active]
582899006681	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
582899006682	ferrochelatase; Reviewed; Region: hemH; PRK00035
582899006683	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
582899006684	C-terminal domain interface [polypeptide binding]; other site
582899006685	active site
582899006686	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
582899006687	active site
582899006688	N-terminal domain interface [polypeptide binding]; other site
582899006689	CHAD domain; Region: CHAD; pfam05235
582899006690	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
582899006691	thiamine phosphate binding site [chemical binding]; other site
582899006692	active site
582899006693	pyrophosphate binding site [ion binding]; other site
582899006694	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
582899006695	ThiS interaction site; other site
582899006696	putative active site [active]
582899006697	tetramer interface [polypeptide binding]; other site
582899006698	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
582899006699	thiS-thiF/thiG interaction site; other site
582899006700	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
582899006701	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582899006702	putative acyl-acceptor binding pocket; other site
582899006703	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
582899006704	acyl-activating enzyme (AAE) consensus motif; other site
582899006705	AMP binding site [chemical binding]; other site
582899006706	active site
582899006707	CoA binding site [chemical binding]; other site
582899006708	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899006709	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
582899006710	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
582899006711	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
582899006712	Cupin domain; Region: Cupin_2; pfam07883
582899006713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
582899006714	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899006715	lipoyl synthase; Provisional; Region: PRK05481
582899006716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899006717	FeS/SAM binding site; other site
582899006718	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
582899006719	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
582899006720	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582899006721	dimerization interface [polypeptide binding]; other site
582899006722	putative Zn2+ binding site [ion binding]; other site
582899006723	putative DNA binding site [nucleotide binding]; other site
582899006724	The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444
582899006725	putative substrate binding site [chemical binding]; other site
582899006726	dimerization interface [polypeptide binding]; other site
582899006727	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
582899006728	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
582899006729	Walker A/P-loop; other site
582899006730	ATP binding site [chemical binding]; other site
582899006731	Q-loop/lid; other site
582899006732	ABC transporter signature motif; other site
582899006733	Walker B; other site
582899006734	D-loop; other site
582899006735	H-loop/switch region; other site
582899006736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899006737	dimer interface [polypeptide binding]; other site
582899006738	conserved gate region; other site
582899006739	putative PBP binding loops; other site
582899006740	ABC-ATPase subunit interface; other site
582899006741	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
582899006742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899006743	dimer interface [polypeptide binding]; other site
582899006744	conserved gate region; other site
582899006745	putative PBP binding loops; other site
582899006746	ABC-ATPase subunit interface; other site
582899006747	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582899006748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899006749	non-specific DNA binding site [nucleotide binding]; other site
582899006750	salt bridge; other site
582899006751	sequence-specific DNA binding site [nucleotide binding]; other site
582899006752	Cupin domain; Region: Cupin_2; pfam07883
582899006753	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
582899006754	Serine hydrolase; Region: Ser_hydrolase; pfam06821
582899006755	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582899006756	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
582899006757	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
582899006758	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
582899006759	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582899006760	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
582899006761	FtsX-like permease family; Region: FtsX; pfam02687
582899006762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899006763	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
582899006764	Walker A/P-loop; other site
582899006765	ATP binding site [chemical binding]; other site
582899006766	Q-loop/lid; other site
582899006767	ABC transporter signature motif; other site
582899006768	Walker B; other site
582899006769	D-loop; other site
582899006770	H-loop/switch region; other site
582899006771	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
582899006772	PAS fold; Region: PAS; pfam00989
582899006773	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899006774	heme pocket [chemical binding]; other site
582899006775	putative active site [active]
582899006776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899006777	HWE histidine kinase; Region: HWE_HK; pfam07536
582899006778	two-component response regulator; Provisional; Region: PRK09191
582899006779	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
582899006780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899006781	active site
582899006782	phosphorylation site [posttranslational modification]
582899006783	intermolecular recognition site; other site
582899006784	dimerization interface [polypeptide binding]; other site
582899006785	RNA polymerase sigma factor; Provisional; Region: PRK12547
582899006786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582899006787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
582899006788	DNA binding residues [nucleotide binding]
582899006789	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
582899006790	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899006791	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899006792	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
582899006793	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
582899006794	active site
582899006795	SAM binding site [chemical binding]; other site
582899006796	homodimer interface [polypeptide binding]; other site
582899006797	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
582899006798	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
582899006799	active site
582899006800	putative homodimer interface [polypeptide binding]; other site
582899006801	SAM binding site [chemical binding]; other site
582899006802	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
582899006803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899006804	S-adenosylmethionine binding site [chemical binding]; other site
582899006805	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
582899006806	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
582899006807	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
582899006808	active site
582899006809	SAM binding site [chemical binding]; other site
582899006810	homodimer interface [polypeptide binding]; other site
582899006811	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
582899006812	active site
582899006813	SAM binding site [chemical binding]; other site
582899006814	homodimer interface [polypeptide binding]; other site
582899006815	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
582899006816	Precorrin-8X methylmutase; Region: CbiC; pfam02570
582899006817	precorrin-3B synthase; Region: CobG; TIGR02435
582899006818	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582899006819	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
582899006820	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
582899006821	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
582899006822	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
582899006823	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
582899006824	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
582899006825	homotrimer interface [polypeptide binding]; other site
582899006826	Walker A motif; other site
582899006827	GTP binding site [chemical binding]; other site
582899006828	Walker B motif; other site
582899006829	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
582899006830	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
582899006831	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
582899006832	homodimer interface [polypeptide binding]; other site
582899006833	Walker A motif; other site
582899006834	ATP binding site [chemical binding]; other site
582899006835	hydroxycobalamin binding site [chemical binding]; other site
582899006836	Walker B motif; other site
582899006837	cobyric acid synthase; Provisional; Region: PRK00784
582899006838	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899006839	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
582899006840	catalytic triad [active]
582899006841	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
582899006842	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
582899006843	putative FMN binding site [chemical binding]; other site
582899006844	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
582899006845	active site
582899006846	SAM binding site [chemical binding]; other site
582899006847	homodimer interface [polypeptide binding]; other site
582899006848	hypothetical protein; Validated; Region: PRK01415
582899006849	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
582899006850	active site residue [active]
582899006851	Acyltransferase family; Region: Acyl_transf_3; pfam01757
582899006852	Domain of unknown function (DUF329); Region: DUF329; cl01144
582899006853	Maf-like protein; Region: Maf; pfam02545
582899006854	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582899006855	active site
582899006856	dimer interface [polypeptide binding]; other site
582899006857	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899006858	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899006859	ligand binding site [chemical binding]; other site
582899006860	flexible hinge region; other site
582899006861	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
582899006862	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
582899006863	cyclase homology domain; Region: CHD; cd07302
582899006864	nucleotidyl binding site; other site
582899006865	metal binding site [ion binding]; metal-binding site
582899006866	dimer interface [polypeptide binding]; other site
582899006867	hypothetical protein; Provisional; Region: PRK02853
582899006868	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
582899006869	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
582899006870	NAD binding site [chemical binding]; other site
582899006871	dimerization interface [polypeptide binding]; other site
582899006872	product binding site; other site
582899006873	substrate binding site [chemical binding]; other site
582899006874	zinc binding site [ion binding]; other site
582899006875	catalytic residues [active]
582899006876	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
582899006877	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
582899006878	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
582899006879	hinge; other site
582899006880	active site
582899006881	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582899006882	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
582899006883	active site
582899006884	nucleophile elbow; other site
582899006885	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
582899006886	MgtE intracellular N domain; Region: MgtE_N; pfam03448
582899006887	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
582899006888	Divalent cation transporter; Region: MgtE; pfam01769
582899006889	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899006890	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899006891	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899006892	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582899006893	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
582899006894	GTP cyclohydrolase I; Provisional; Region: PLN03044
582899006895	active site
582899006896	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
582899006897	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
582899006898	dimerization interface 3.5A [polypeptide binding]; other site
582899006899	active site
582899006900	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
582899006901	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
582899006902	putative active site [active]
582899006903	substrate binding site [chemical binding]; other site
582899006904	putative cosubstrate binding site; other site
582899006905	catalytic site [active]
582899006906	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
582899006907	substrate binding site [chemical binding]; other site
582899006908	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
582899006909	active site
582899006910	catalytic residues [active]
582899006911	metal binding site [ion binding]; metal-binding site
582899006912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582899006913	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582899006914	NAD(P) binding site [chemical binding]; other site
582899006915	active site
582899006916	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
582899006917	putative efflux protein, MATE family; Region: matE; TIGR00797
582899006918	recombination protein RecR; Reviewed; Region: recR; PRK00076
582899006919	RecR protein; Region: RecR; pfam02132
582899006920	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
582899006921	putative active site [active]
582899006922	putative metal-binding site [ion binding]; other site
582899006923	tetramer interface [polypeptide binding]; other site
582899006924	hypothetical protein; Validated; Region: PRK00153
582899006925	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
582899006926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899006927	Walker A motif; other site
582899006928	ATP binding site [chemical binding]; other site
582899006929	Walker B motif; other site
582899006930	arginine finger; other site
582899006931	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
582899006932	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
582899006933	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
582899006934	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
582899006935	putative NAD(P) binding site [chemical binding]; other site
582899006936	active site
582899006937	prephenate dehydratase; Provisional; Region: PRK11899
582899006938	Prephenate dehydratase; Region: PDT; pfam00800
582899006939	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
582899006940	putative L-Phe binding site [chemical binding]; other site
582899006941	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
582899006942	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
582899006943	Ligand binding site; other site
582899006944	oligomer interface; other site
582899006945	Cytochrome c2 [Energy production and conversion]; Region: COG3474
582899006946	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
582899006947	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
582899006948	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
582899006949	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
582899006950	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
582899006951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899006952	dimer interface [polypeptide binding]; other site
582899006953	conserved gate region; other site
582899006954	putative PBP binding loops; other site
582899006955	ABC-ATPase subunit interface; other site
582899006956	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
582899006957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
582899006958	dimer interface [polypeptide binding]; other site
582899006959	conserved gate region; other site
582899006960	putative PBP binding loops; other site
582899006961	ABC-ATPase subunit interface; other site
582899006962	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
582899006963	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
582899006964	Walker A/P-loop; other site
582899006965	ATP binding site [chemical binding]; other site
582899006966	Q-loop/lid; other site
582899006967	ABC transporter signature motif; other site
582899006968	Walker B; other site
582899006969	D-loop; other site
582899006970	H-loop/switch region; other site
582899006971	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
582899006972	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
582899006973	Walker A/P-loop; other site
582899006974	ATP binding site [chemical binding]; other site
582899006975	Q-loop/lid; other site
582899006976	ABC transporter signature motif; other site
582899006977	Walker B; other site
582899006978	D-loop; other site
582899006979	H-loop/switch region; other site
582899006980	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
582899006981	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582899006982	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899006983	ligand binding site [chemical binding]; other site
582899006984	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
582899006985	Staphylococcal nuclease homologues; Region: SNc; smart00318
582899006986	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
582899006987	Catalytic site; other site
582899006988	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
582899006989	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
582899006990	AsmA family; Region: AsmA; pfam05170
582899006991	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
582899006992	Uncharacterized conserved protein [Function unknown]; Region: COG5649
582899006993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899006994	putative transporter; Provisional; Region: PRK10504
582899006995	putative substrate translocation pore; other site
582899006996	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
582899006997	Coenzyme A transferase; Region: CoA_trans; smart00882
582899006998	Coenzyme A transferase; Region: CoA_trans; cl17247
582899006999	Cytochrome c [Energy production and conversion]; Region: COG3258
582899007000	Cytochrome c; Region: Cytochrom_C; pfam00034
582899007001	Domain of unknown function DUF59; Region: DUF59; pfam01883
582899007002	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
582899007003	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
582899007004	Walker A motif; other site
582899007005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
582899007006	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
582899007007	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
582899007008	GTP binding site; other site
582899007009	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
582899007010	Walker A motif; other site
582899007011	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
582899007012	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899007013	FeS/SAM binding site; other site
582899007014	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
582899007015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007016	active site
582899007017	phosphorylation site [posttranslational modification]
582899007018	intermolecular recognition site; other site
582899007019	dimerization interface [polypeptide binding]; other site
582899007020	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899007021	active site
582899007022	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
582899007023	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582899007024	Walker A/P-loop; other site
582899007025	ATP binding site [chemical binding]; other site
582899007026	Q-loop/lid; other site
582899007027	ABC transporter signature motif; other site
582899007028	Walker B; other site
582899007029	D-loop; other site
582899007030	H-loop/switch region; other site
582899007031	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
582899007032	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
582899007033	Uncharacterized conserved protein [Function unknown]; Region: COG1434
582899007034	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
582899007035	putative active site [active]
582899007036	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582899007037	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582899007038	putative acyl-acceptor binding pocket; other site
582899007039	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
582899007040	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
582899007041	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
582899007042	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
582899007043	active site
582899007044	dimer interface [polypeptide binding]; other site
582899007045	effector binding site; other site
582899007046	TSCPD domain; Region: TSCPD; pfam12637
582899007047	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
582899007048	prephenate dehydrogenase; Validated; Region: PRK08507
582899007049	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
582899007050	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899007051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899007052	homodimer interface [polypeptide binding]; other site
582899007053	catalytic residue [active]
582899007054	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
582899007055	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
582899007056	Methyltransferase domain; Region: Methyltransf_31; pfam13847
582899007057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899007058	S-adenosylmethionine binding site [chemical binding]; other site
582899007059	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899007060	Methyltransferase domain; Region: Methyltransf_11; pfam08241
582899007061	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
582899007062	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
582899007063	LabA_like proteins; Region: LabA_like; cd06167
582899007064	putative metal binding site [ion binding]; other site
582899007065	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
582899007066	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
582899007067	NAD(P) binding site [chemical binding]; other site
582899007068	homotetramer interface [polypeptide binding]; other site
582899007069	homodimer interface [polypeptide binding]; other site
582899007070	active site
582899007071	putative acyltransferase; Provisional; Region: PRK05790
582899007072	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
582899007073	dimer interface [polypeptide binding]; other site
582899007074	active site
582899007075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
582899007076	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
582899007077	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
582899007078	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582899007079	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899007080	metal binding site [ion binding]; metal-binding site
582899007081	active site
582899007082	I-site; other site
582899007083	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899007084	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
582899007085	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
582899007086	Transglycosylase; Region: Transgly; cl17702
582899007087	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
582899007088	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582899007089	substrate binding pocket [chemical binding]; other site
582899007090	chain length determination region; other site
582899007091	substrate-Mg2+ binding site; other site
582899007092	catalytic residues [active]
582899007093	aspartate-rich region 1; other site
582899007094	active site lid residues [active]
582899007095	aspartate-rich region 2; other site
582899007096	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899007097	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
582899007098	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
582899007099	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
582899007100	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
582899007101	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
582899007102	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
582899007103	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
582899007104	putative PBP binding regions; other site
582899007105	ABC-ATPase subunit  interface; other site
582899007106	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
582899007107	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
582899007108	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
582899007109	metal binding site 2 [ion binding]; metal-binding site
582899007110	putative DNA binding helix; other site
582899007111	metal binding site 1 [ion binding]; metal-binding site
582899007112	dimer interface [polypeptide binding]; other site
582899007113	structural Zn2+ binding site [ion binding]; other site
582899007114	PUCC protein; Region: PUCC; pfam03209
582899007115	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
582899007116	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
582899007117	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
582899007118	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
582899007119	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
582899007120	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
582899007121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899007122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899007123	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
582899007124	putative effector binding pocket; other site
582899007125	putative dimerization interface [polypeptide binding]; other site
582899007126	short chain dehydrogenase; Provisional; Region: PRK12744
582899007127	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
582899007128	NADP binding site [chemical binding]; other site
582899007129	homodimer interface [polypeptide binding]; other site
582899007130	active site
582899007131	substrate binding site [chemical binding]; other site
582899007132	glycine dehydrogenase; Provisional; Region: PRK05367
582899007133	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
582899007134	tetramer interface [polypeptide binding]; other site
582899007135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899007136	catalytic residue [active]
582899007137	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
582899007138	tetramer interface [polypeptide binding]; other site
582899007139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899007140	catalytic residue [active]
582899007141	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
582899007142	lipoyl attachment site [posttranslational modification]; other site
582899007143	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
582899007144	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582899007145	SET domain; Region: SET; pfam00856
582899007146	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
582899007147	heme binding pocket [chemical binding]; other site
582899007148	heme ligand [chemical binding]; other site
582899007149	Cache domain; Region: Cache_1; pfam02743
582899007150	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582899007151	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582899007152	dimer interface [polypeptide binding]; other site
582899007153	putative CheW interface [polypeptide binding]; other site
582899007154	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
582899007155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899007156	ATP binding site [chemical binding]; other site
582899007157	Mg2+ binding site [ion binding]; other site
582899007158	G-X-G motif; other site
582899007159	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899007160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007161	active site
582899007162	phosphorylation site [posttranslational modification]
582899007163	intermolecular recognition site; other site
582899007164	dimerization interface [polypeptide binding]; other site
582899007165	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899007166	DNA binding site [nucleotide binding]
582899007167	Predicted membrane protein [Function unknown]; Region: COG3212
582899007168	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
582899007169	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
582899007170	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
582899007171	Isochorismatase family; Region: Isochorismatase; pfam00857
582899007172	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
582899007173	catalytic triad [active]
582899007174	dimer interface [polypeptide binding]; other site
582899007175	conserved cis-peptide bond; other site
582899007176	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
582899007177	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
582899007178	UreD urease accessory protein; Region: UreD; pfam01774
582899007179	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
582899007180	urease subunit alpha; Reviewed; Region: ureC; PRK13308
582899007181	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
582899007182	subunit interactions [polypeptide binding]; other site
582899007183	active site
582899007184	flap region; other site
582899007185	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
582899007186	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
582899007187	alpha-gamma subunit interface [polypeptide binding]; other site
582899007188	beta-gamma subunit interface [polypeptide binding]; other site
582899007189	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
582899007190	gamma-beta subunit interface [polypeptide binding]; other site
582899007191	alpha-beta subunit interface [polypeptide binding]; other site
582899007192	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
582899007193	UreF; Region: UreF; pfam01730
582899007194	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
582899007195	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
582899007196	dimer interface [polypeptide binding]; other site
582899007197	catalytic residues [active]
582899007198	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
582899007199	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
582899007200	Walker A/P-loop; other site
582899007201	ATP binding site [chemical binding]; other site
582899007202	Q-loop/lid; other site
582899007203	ABC transporter signature motif; other site
582899007204	Walker B; other site
582899007205	D-loop; other site
582899007206	H-loop/switch region; other site
582899007207	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
582899007208	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
582899007209	Walker A/P-loop; other site
582899007210	ATP binding site [chemical binding]; other site
582899007211	Q-loop/lid; other site
582899007212	ABC transporter signature motif; other site
582899007213	Walker B; other site
582899007214	D-loop; other site
582899007215	H-loop/switch region; other site
582899007216	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
582899007217	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
582899007218	TM-ABC transporter signature motif; other site
582899007219	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
582899007220	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
582899007221	TM-ABC transporter signature motif; other site
582899007222	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899007223	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
582899007224	ligand binding site [chemical binding]; other site
582899007225	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
582899007226	ANTAR domain; Region: ANTAR; pfam03861
582899007227	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899007228	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
582899007229	ligand binding site [chemical binding]; other site
582899007230	regulator interaction site; other site
582899007231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899007232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899007233	ATP binding site [chemical binding]; other site
582899007234	Mg2+ binding site [ion binding]; other site
582899007235	G-X-G motif; other site
582899007236	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
582899007237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007238	active site
582899007239	phosphorylation site [posttranslational modification]
582899007240	intermolecular recognition site; other site
582899007241	dimerization interface [polypeptide binding]; other site
582899007242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899007243	DNA binding site [nucleotide binding]
582899007244	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899007245	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899007246	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899007247	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582899007248	K+-transporting ATPase, c chain; Region: KdpC; cl00944
582899007249	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
582899007250	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
582899007251	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
582899007252	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
582899007253	FAD binding pocket [chemical binding]; other site
582899007254	FAD binding motif [chemical binding]; other site
582899007255	phosphate binding motif [ion binding]; other site
582899007256	beta-alpha-beta structure motif; other site
582899007257	NAD binding pocket [chemical binding]; other site
582899007258	short chain dehydrogenase; Provisional; Region: PRK06500
582899007259	classical (c) SDRs; Region: SDR_c; cd05233
582899007260	NAD(P) binding site [chemical binding]; other site
582899007261	active site
582899007262	Transcriptional regulator; Region: Rrf2; pfam02082
582899007263	Rrf2 family protein; Region: rrf2_super; TIGR00738
582899007264	RibD C-terminal domain; Region: RibD_C; cl17279
582899007265	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899007266	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899007267	DNA binding residues [nucleotide binding]
582899007268	dimerization interface [polypeptide binding]; other site
582899007269	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
582899007270	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
582899007271	Autotransporter beta-domain; Region: Autotransporter; pfam03797
582899007272	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
582899007273	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582899007274	N-terminal plug; other site
582899007275	ligand-binding site [chemical binding]; other site
582899007276	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582899007277	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899007278	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
582899007279	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
582899007280	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
582899007281	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
582899007282	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
582899007283	dimer interface [polypeptide binding]; other site
582899007284	anticodon binding site; other site
582899007285	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
582899007286	homodimer interface [polypeptide binding]; other site
582899007287	motif 1; other site
582899007288	active site
582899007289	motif 2; other site
582899007290	GAD domain; Region: GAD; pfam02938
582899007291	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582899007292	active site
582899007293	motif 3; other site
582899007294	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
582899007295	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
582899007296	catalytic site [active]
582899007297	putative active site [active]
582899007298	putative substrate binding site [chemical binding]; other site
582899007299	HRDC domain; Region: HRDC; pfam00570
582899007300	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
582899007301	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582899007302	HSP70 interaction site [polypeptide binding]; other site
582899007303	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
582899007304	substrate binding site [polypeptide binding]; other site
582899007305	dimer interface [polypeptide binding]; other site
582899007306	exopolyphosphatase; Region: exo_poly_only; TIGR03706
582899007307	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
582899007308	polyphosphate kinase; Provisional; Region: PRK05443
582899007309	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
582899007310	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
582899007311	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
582899007312	putative domain interface [polypeptide binding]; other site
582899007313	putative active site [active]
582899007314	catalytic site [active]
582899007315	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
582899007316	putative active site [active]
582899007317	putative domain interface [polypeptide binding]; other site
582899007318	catalytic site [active]
582899007319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582899007320	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
582899007321	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
582899007322	Domain of unknown function DUF20; Region: UPF0118; pfam01594
582899007323	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
582899007324	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
582899007325	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
582899007326	dimerization interface [polypeptide binding]; other site
582899007327	putative ATP binding site [chemical binding]; other site
582899007328	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582899007329	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
582899007330	Trp docking motif [polypeptide binding]; other site
582899007331	dimer interface [polypeptide binding]; other site
582899007332	active site
582899007333	small subunit binding site [polypeptide binding]; other site
582899007334	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582899007335	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
582899007336	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
582899007337	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
582899007338	active site
582899007339	substrate binding site [chemical binding]; other site
582899007340	cosubstrate binding site; other site
582899007341	catalytic site [active]
582899007342	Cytochrome P450; Region: p450; cl12078
582899007343	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
582899007344	Cytochrome P450; Region: p450; cl12078
582899007345	DinB family; Region: DinB; cl17821
582899007346	DinB superfamily; Region: DinB_2; pfam12867
582899007347	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
582899007348	active site
582899007349	multimer interface [polypeptide binding]; other site
582899007350	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
582899007351	hypothetical protein; Provisional; Region: PRK09272
582899007352	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
582899007353	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899007354	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899007355	ABC transporter; Region: ABC_tran_2; pfam12848
582899007356	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
582899007357	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
582899007358	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
582899007359	Chromate transporter; Region: Chromate_transp; pfam02417
582899007360	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
582899007361	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
582899007362	dimer interface [polypeptide binding]; other site
582899007363	motif 1; other site
582899007364	active site
582899007365	motif 2; other site
582899007366	motif 3; other site
582899007367	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
582899007368	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
582899007369	tandem repeat interface [polypeptide binding]; other site
582899007370	oligomer interface [polypeptide binding]; other site
582899007371	active site residues [active]
582899007372	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
582899007373	Methyltransferase domain; Region: Methyltransf_26; pfam13659
582899007374	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
582899007375	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
582899007376	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582899007377	substrate binding pocket [chemical binding]; other site
582899007378	chain length determination region; other site
582899007379	substrate-Mg2+ binding site; other site
582899007380	catalytic residues [active]
582899007381	aspartate-rich region 1; other site
582899007382	active site lid residues [active]
582899007383	aspartate-rich region 2; other site
582899007384	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
582899007385	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
582899007386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899007387	binding surface
582899007388	TPR motif; other site
582899007389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
582899007390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899007391	binding surface
582899007392	TPR motif; other site
582899007393	TPR repeat; Region: TPR_11; pfam13414
582899007394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
582899007395	binding surface
582899007396	TPR motif; other site
582899007397	TPR repeat; Region: TPR_11; pfam13414
582899007398	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
582899007399	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
582899007400	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
582899007401	Fe-S cluster binding site [ion binding]; other site
582899007402	active site
582899007403	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
582899007404	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
582899007405	MPT binding site; other site
582899007406	trimer interface [polypeptide binding]; other site
582899007407	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582899007408	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
582899007409	active site
582899007410	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
582899007411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899007412	FeS/SAM binding site; other site
582899007413	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
582899007414	RNA/DNA hybrid binding site [nucleotide binding]; other site
582899007415	active site
582899007416	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
582899007417	DNA methylase; Region: N6_N4_Mtase; pfam01555
582899007418	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
582899007419	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582899007420	minor groove reading motif; other site
582899007421	helix-hairpin-helix signature motif; other site
582899007422	substrate binding pocket [chemical binding]; other site
582899007423	active site
582899007424	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
582899007425	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
582899007426	DNA binding and oxoG recognition site [nucleotide binding]
582899007427	Protein of unknown function (DUF721); Region: DUF721; cl02324
582899007428	Thioredoxin; Region: Thioredoxin_4; pfam13462
582899007429	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
582899007430	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
582899007431	Thioredoxin; Region: Thioredoxin_4; pfam13462
582899007432	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
582899007433	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
582899007434	Walker A/P-loop; other site
582899007435	ATP binding site [chemical binding]; other site
582899007436	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
582899007437	Q-loop/lid; other site
582899007438	ABC transporter signature motif; other site
582899007439	Walker B; other site
582899007440	D-loop; other site
582899007441	H-loop/switch region; other site
582899007442	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
582899007443	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
582899007444	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
582899007445	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
582899007446	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
582899007447	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
582899007448	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
582899007449	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
582899007450	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
582899007451	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
582899007452	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
582899007453	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
582899007454	putative active site [active]
582899007455	putative substrate binding site [chemical binding]; other site
582899007456	ATP binding site [chemical binding]; other site
582899007457	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
582899007458	RNA/DNA hybrid binding site [nucleotide binding]; other site
582899007459	active site
582899007460	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
582899007461	catalytic triad [active]
582899007462	dimer interface [polypeptide binding]; other site
582899007463	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
582899007464	hypothetical protein; Validated; Region: PRK00228
582899007465	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
582899007466	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899007467	PAS fold; Region: PAS_3; pfam08447
582899007468	putative active site [active]
582899007469	heme pocket [chemical binding]; other site
582899007470	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582899007471	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899007472	metal binding site [ion binding]; metal-binding site
582899007473	active site
582899007474	I-site; other site
582899007475	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899007476	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
582899007477	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
582899007478	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582899007479	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582899007480	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582899007481	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
582899007482	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
582899007483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899007484	catalytic residue [active]
582899007485	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
582899007486	Protein of unknown function (DUF983); Region: DUF983; cl02211
582899007487	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
582899007488	Subunit III/VIIa interface [polypeptide binding]; other site
582899007489	Phospholipid binding site [chemical binding]; other site
582899007490	Subunit I/III interface [polypeptide binding]; other site
582899007491	Subunit III/VIb interface [polypeptide binding]; other site
582899007492	Subunit III/VIa interface; other site
582899007493	Subunit III/Vb interface [polypeptide binding]; other site
582899007494	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
582899007495	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
582899007496	UbiA prenyltransferase family; Region: UbiA; pfam01040
582899007497	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
582899007498	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
582899007499	Subunit I/III interface [polypeptide binding]; other site
582899007500	D-pathway; other site
582899007501	Subunit I/VIIc interface [polypeptide binding]; other site
582899007502	Subunit I/IV interface [polypeptide binding]; other site
582899007503	Subunit I/II interface [polypeptide binding]; other site
582899007504	Low-spin heme (heme a) binding site [chemical binding]; other site
582899007505	Subunit I/VIIa interface [polypeptide binding]; other site
582899007506	Subunit I/VIa interface [polypeptide binding]; other site
582899007507	Dimer interface; other site
582899007508	Putative water exit pathway; other site
582899007509	Binuclear center (heme a3/CuB) [ion binding]; other site
582899007510	K-pathway; other site
582899007511	Subunit I/Vb interface [polypeptide binding]; other site
582899007512	Putative proton exit pathway; other site
582899007513	Subunit I/VIb interface; other site
582899007514	Subunit I/VIc interface [polypeptide binding]; other site
582899007515	Electron transfer pathway; other site
582899007516	Subunit I/VIIIb interface [polypeptide binding]; other site
582899007517	Subunit I/VIIb interface [polypeptide binding]; other site
582899007518	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
582899007519	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
582899007520	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
582899007521	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
582899007522	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582899007523	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582899007524	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899007525	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899007526	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899007527	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582899007528	Protein of unknown function (DUF533); Region: DUF533; pfam04391
582899007529	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
582899007530	putative metal binding site [ion binding]; other site
582899007531	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
582899007532	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899007533	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582899007534	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582899007535	Walker A/P-loop; other site
582899007536	ATP binding site [chemical binding]; other site
582899007537	Q-loop/lid; other site
582899007538	ABC transporter signature motif; other site
582899007539	Walker B; other site
582899007540	D-loop; other site
582899007541	H-loop/switch region; other site
582899007542	DevC protein; Region: devC; TIGR01185
582899007543	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582899007544	FtsX-like permease family; Region: FtsX; pfam02687
582899007545	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
582899007546	Esterase/lipase [General function prediction only]; Region: COG1647
582899007547	aminodeoxychorismate synthase; Provisional; Region: PRK07508
582899007548	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582899007549	chorismate binding enzyme; Region: Chorismate_bind; cl10555
582899007550	hypothetical protein; Provisional; Region: PRK07546
582899007551	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
582899007552	substrate-cofactor binding pocket; other site
582899007553	hypothetical protein; Provisional; Region: PRK06185
582899007554	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899007555	PAS fold; Region: PAS_4; pfam08448
582899007556	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899007557	HWE histidine kinase; Region: HWE_HK; smart00911
582899007558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
582899007559	Mg2+ binding site [ion binding]; other site
582899007560	G-X-G motif; other site
582899007561	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
582899007562	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
582899007563	Cl binding site [ion binding]; other site
582899007564	oligomer interface [polypeptide binding]; other site
582899007565	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
582899007566	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
582899007567	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582899007568	Soluble P-type ATPase [General function prediction only]; Region: COG4087
582899007569	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
582899007570	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
582899007571	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
582899007572	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
582899007573	Ligand Binding Site [chemical binding]; other site
582899007574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899007575	dimer interface [polypeptide binding]; other site
582899007576	phosphorylation site [posttranslational modification]
582899007577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899007578	ATP binding site [chemical binding]; other site
582899007579	Mg2+ binding site [ion binding]; other site
582899007580	G-X-G motif; other site
582899007581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899007582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007583	active site
582899007584	phosphorylation site [posttranslational modification]
582899007585	intermolecular recognition site; other site
582899007586	dimerization interface [polypeptide binding]; other site
582899007587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899007588	DNA binding site [nucleotide binding]
582899007589	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582899007590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582899007591	DNA-binding site [nucleotide binding]; DNA binding site
582899007592	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582899007593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899007594	homodimer interface [polypeptide binding]; other site
582899007595	catalytic residue [active]
582899007596	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
582899007597	Uncharacterized conserved protein [Function unknown]; Region: COG1262
582899007598	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
582899007599	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
582899007600	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
582899007601	Sulfatase; Region: Sulfatase; pfam00884
582899007602	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
582899007603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899007604	motif II; other site
582899007605	Uncharacterized conserved protein [Function unknown]; Region: COG5361
582899007606	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
582899007607	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
582899007608	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
582899007609	Uncharacterized conserved protein [Function unknown]; Region: COG5361
582899007610	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
582899007611	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
582899007612	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
582899007613	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899007614	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899007615	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
582899007616	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
582899007617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007618	active site
582899007619	phosphorylation site [posttranslational modification]
582899007620	intermolecular recognition site; other site
582899007621	ANTAR domain; Region: ANTAR; pfam03861
582899007622	NMT1-like family; Region: NMT1_2; pfam13379
582899007623	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582899007624	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
582899007625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899007626	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
582899007627	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899007628	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582899007629	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582899007630	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
582899007631	[2Fe-2S] cluster binding site [ion binding]; other site
582899007632	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
582899007633	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
582899007634	[4Fe-4S] binding site [ion binding]; other site
582899007635	molybdopterin cofactor binding site; other site
582899007636	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
582899007637	molybdopterin cofactor binding site; other site
582899007638	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
582899007639	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
582899007640	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
582899007641	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
582899007642	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
582899007643	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
582899007644	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
582899007645	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
582899007646	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
582899007647	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
582899007648	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
582899007649	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
582899007650	oligomerization interface [polypeptide binding]; other site
582899007651	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
582899007652	Phage capsid family; Region: Phage_capsid; pfam05065
582899007653	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
582899007654	Phage portal protein; Region: Phage_portal; pfam04860
582899007655	Phage-related protein [Function unknown]; Region: COG4695; cl01923
582899007656	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
582899007657	Phage terminase, small subunit; Region: Terminase_4; cl01525
582899007658	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
582899007659	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
582899007660	active site
582899007661	TM2 domain; Region: TM2; pfam05154
582899007662	Arginine repressor [Transcription]; Region: ArgR; COG1438
582899007663	Transcriptional regulator; Region: Rrf2; cl17282
582899007664	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
582899007665	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
582899007666	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899007667	ATP binding site [chemical binding]; other site
582899007668	putative Mg++ binding site [ion binding]; other site
582899007669	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
582899007670	MT-A70; Region: MT-A70; cl01947
582899007671	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
582899007672	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
582899007673	cofactor binding site; other site
582899007674	DNA binding site [nucleotide binding]
582899007675	substrate interaction site [chemical binding]; other site
582899007676	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
582899007677	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
582899007678	DnaA N-terminal domain; Region: DnaA_N; pfam11638
582899007679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899007680	non-specific DNA binding site [nucleotide binding]; other site
582899007681	salt bridge; other site
582899007682	sequence-specific DNA binding site [nucleotide binding]; other site
582899007683	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
582899007684	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
582899007685	active site
582899007686	catalytic site [active]
582899007687	substrate binding site [chemical binding]; other site
582899007688	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899007689	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
582899007690	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
582899007691	catalytic residues [active]
582899007692	catalytic nucleophile [active]
582899007693	Recombinase; Region: Recombinase; pfam07508
582899007694	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
582899007695	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582899007696	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899007697	P-loop; other site
582899007698	Magnesium ion binding site [ion binding]; other site
582899007699	Transglycosylase SLT domain; Region: SLT_2; pfam13406
582899007700	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
582899007701	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582899007702	MarR family; Region: MarR_2; pfam12802
582899007703	Protein of unknown function (DUF512); Region: DUF512; pfam04459
582899007704	dihydropteroate synthase-related protein; Region: TIGR00284
582899007705	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
582899007706	substrate binding pocket [chemical binding]; other site
582899007707	dimer interface [polypeptide binding]; other site
582899007708	inhibitor binding site; inhibition site
582899007709	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
582899007710	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
582899007711	active site
582899007712	SAM binding site [chemical binding]; other site
582899007713	homodimer interface [polypeptide binding]; other site
582899007714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899007715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899007716	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582899007717	putative effector binding pocket; other site
582899007718	dimerization interface [polypeptide binding]; other site
582899007719	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
582899007720	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582899007721	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
582899007722	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899007723	Zn binding site [ion binding]; other site
582899007724	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
582899007725	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899007726	Zn binding site [ion binding]; other site
582899007727	putative hydrolase; Provisional; Region: PRK11460
582899007728	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582899007729	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
582899007730	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
582899007731	[2Fe-2S] cluster binding site [ion binding]; other site
582899007732	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
582899007733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899007734	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899007735	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
582899007736	Ferritin-like domain; Region: Ferritin; pfam00210
582899007737	dimerization interface [polypeptide binding]; other site
582899007738	DPS ferroxidase diiron center [ion binding]; other site
582899007739	ion pore; other site
582899007740	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
582899007741	ligand binding site; other site
582899007742	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
582899007743	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
582899007744	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
582899007745	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
582899007746	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
582899007747	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
582899007748	FHIPEP family; Region: FHIPEP; pfam00771
582899007749	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
582899007750	Rod binding protein; Region: Rod-binding; cl01626
582899007751	CheD chemotactic sensory transduction; Region: CheD; cl00810
582899007752	Response regulator receiver domain; Region: Response_reg; pfam00072
582899007753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007754	active site
582899007755	phosphorylation site [posttranslational modification]
582899007756	intermolecular recognition site; other site
582899007757	dimerization interface [polypeptide binding]; other site
582899007758	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
582899007759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007760	active site
582899007761	phosphorylation site [posttranslational modification]
582899007762	intermolecular recognition site; other site
582899007763	dimerization interface [polypeptide binding]; other site
582899007764	CheB methylesterase; Region: CheB_methylest; pfam01339
582899007765	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
582899007766	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582899007767	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
582899007768	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
582899007769	putative CheA interaction surface; other site
582899007770	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
582899007771	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582899007772	putative binding surface; other site
582899007773	active site
582899007774	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582899007775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899007776	ATP binding site [chemical binding]; other site
582899007777	Mg2+ binding site [ion binding]; other site
582899007778	G-X-G motif; other site
582899007779	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582899007780	Response regulator receiver domain; Region: Response_reg; pfam00072
582899007781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007782	active site
582899007783	phosphorylation site [posttranslational modification]
582899007784	intermolecular recognition site; other site
582899007785	dimerization interface [polypeptide binding]; other site
582899007786	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
582899007787	anti sigma factor interaction site; other site
582899007788	regulatory phosphorylation site [posttranslational modification]; other site
582899007789	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
582899007790	dimer interface [polypeptide binding]; other site
582899007791	putative CheW interface [polypeptide binding]; other site
582899007792	PilZ domain; Region: PilZ; pfam07238
582899007793	PAS domain; Region: PAS_9; pfam13426
582899007794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899007795	putative active site [active]
582899007796	heme pocket [chemical binding]; other site
582899007797	PAS fold; Region: PAS_7; pfam12860
582899007798	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582899007799	PilZ domain; Region: PilZ; pfam07238
582899007800	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
582899007801	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582899007802	metal binding site [ion binding]; metal-binding site
582899007803	active site
582899007804	I-site; other site
582899007805	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
582899007806	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
582899007807	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
582899007808	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
582899007809	Flagellar protein FlaF; Region: FlaF; cl11454
582899007810	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
582899007811	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
582899007812	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582899007813	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582899007814	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
582899007815	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582899007816	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
582899007817	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582899007818	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
582899007819	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582899007820	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899007821	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899007822	DNA binding site [nucleotide binding]
582899007823	PilZ domain; Region: PilZ; pfam07238
582899007824	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
582899007825	HSP70 interaction site [polypeptide binding]; other site
582899007826	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
582899007827	chemotaxis protein; Reviewed; Region: PRK12798
582899007828	flagellar motor protein MotB; Validated; Region: motB; PRK05996
582899007829	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
582899007830	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899007831	ligand binding site [chemical binding]; other site
582899007832	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
582899007833	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
582899007834	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
582899007835	flagellin; Reviewed; Region: PRK12687
582899007836	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582899007837	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582899007838	FliP family; Region: FliP; cl00593
582899007839	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
582899007840	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
582899007841	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
582899007842	Uncharacterized conserved protein [Function unknown]; Region: COG3334
582899007843	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
582899007844	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
582899007845	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
582899007846	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
582899007847	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
582899007848	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582899007849	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
582899007850	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
582899007851	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582899007852	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
582899007853	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
582899007854	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
582899007855	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
582899007856	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
582899007857	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
582899007858	FliG C-terminal domain; Region: FliG_C; pfam01706
582899007859	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
582899007860	Flagellar motor switch protein FliM; Region: FliM; pfam02154
582899007861	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
582899007862	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
582899007863	flagellar motor protein MotA; Validated; Region: PRK09110
582899007864	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
582899007865	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
582899007866	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
582899007867	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
582899007868	Walker A motif; other site
582899007869	ATP binding site [chemical binding]; other site
582899007870	Walker B motif; other site
582899007871	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
582899007872	catalytic residue [active]
582899007873	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582899007874	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
582899007875	FOG: CBS domain [General function prediction only]; Region: COG0517
582899007876	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
582899007877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899007878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899007879	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582899007880	dimerization interface [polypeptide binding]; other site
582899007881	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
582899007882	hydroxyglutarate oxidase; Provisional; Region: PRK11728
582899007883	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
582899007884	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
582899007885	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
582899007886	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582899007887	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
582899007888	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
582899007889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899007890	non-specific DNA binding site [nucleotide binding]; other site
582899007891	salt bridge; other site
582899007892	sequence-specific DNA binding site [nucleotide binding]; other site
582899007893	Cupin domain; Region: Cupin_2; pfam07883
582899007894	Sulfatase; Region: Sulfatase; cl17466
582899007895	Uncharacterized conserved protein [Function unknown]; Region: COG3287
582899007896	FIST N domain; Region: FIST; pfam08495
582899007897	FIST C domain; Region: FIST_C; pfam10442
582899007898	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899007899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899007900	dimer interface [polypeptide binding]; other site
582899007901	phosphorylation site [posttranslational modification]
582899007902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899007903	ATP binding site [chemical binding]; other site
582899007904	Mg2+ binding site [ion binding]; other site
582899007905	G-X-G motif; other site
582899007906	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899007907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007908	active site
582899007909	phosphorylation site [posttranslational modification]
582899007910	intermolecular recognition site; other site
582899007911	dimerization interface [polypeptide binding]; other site
582899007912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899007913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899007914	active site
582899007915	phosphorylation site [posttranslational modification]
582899007916	intermolecular recognition site; other site
582899007917	dimerization interface [polypeptide binding]; other site
582899007918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899007919	DNA binding residues [nucleotide binding]
582899007920	dimerization interface [polypeptide binding]; other site
582899007921	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
582899007922	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582899007923	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
582899007924	putative NAD(P) binding site [chemical binding]; other site
582899007925	active site
582899007926	putative substrate binding site [chemical binding]; other site
582899007927	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
582899007928	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899007929	ATP binding site [chemical binding]; other site
582899007930	putative Mg++ binding site [ion binding]; other site
582899007931	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899007932	nucleotide binding region [chemical binding]; other site
582899007933	ATP-binding site [chemical binding]; other site
582899007934	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
582899007935	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
582899007936	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
582899007937	substrate binding site [chemical binding]; other site
582899007938	hexamer interface [polypeptide binding]; other site
582899007939	metal binding site [ion binding]; metal-binding site
582899007940	phosphoribulokinase; Provisional; Region: PRK15453
582899007941	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
582899007942	AMP binding site [chemical binding]; other site
582899007943	metal binding site [ion binding]; metal-binding site
582899007944	active site
582899007945	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
582899007946	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
582899007947	active site
582899007948	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582899007949	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582899007950	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
582899007951	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
582899007952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
582899007953	Uncharacterized conserved protein [Function unknown]; Region: COG2308
582899007954	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
582899007955	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
582899007956	Potassium binding sites [ion binding]; other site
582899007957	Cesium cation binding sites [ion binding]; other site
582899007958	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
582899007959	putative dimer interface [polypeptide binding]; other site
582899007960	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899007961	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
582899007962	active site
582899007963	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
582899007964	phosphopeptide binding site; other site
582899007965	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
582899007966	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
582899007967	phosphopeptide binding site; other site
582899007968	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
582899007969	Catalytic domain of Protein Kinases; Region: PKc; cd00180
582899007970	active site
582899007971	ATP binding site [chemical binding]; other site
582899007972	substrate binding site [chemical binding]; other site
582899007973	activation loop (A-loop); other site
582899007974	FOG: WD40 repeat [General function prediction only]; Region: COG2319
582899007975	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
582899007976	structural tetrad; other site
582899007977	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
582899007978	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
582899007979	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
582899007980	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
582899007981	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
582899007982	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
582899007983	Catalytic site; other site
582899007984	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
582899007985	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
582899007986	putative di-iron ligands [ion binding]; other site
582899007987	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
582899007988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899007989	S-adenosylmethionine binding site [chemical binding]; other site
582899007990	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
582899007991	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
582899007992	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
582899007993	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
582899007994	CoA binding domain; Region: CoA_binding; smart00881
582899007995	CoA-ligase; Region: Ligase_CoA; pfam00549
582899007996	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
582899007997	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
582899007998	CoA-ligase; Region: Ligase_CoA; pfam00549
582899007999	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582899008000	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
582899008001	homodimer interface [polypeptide binding]; other site
582899008002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899008003	catalytic residue [active]
582899008004	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899008005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008006	active site
582899008007	phosphorylation site [posttranslational modification]
582899008008	intermolecular recognition site; other site
582899008009	dimerization interface [polypeptide binding]; other site
582899008010	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899008011	dimerization interface [polypeptide binding]; other site
582899008012	DNA binding residues [nucleotide binding]
582899008013	Staphylococcal nuclease homologues; Region: SNc; smart00318
582899008014	Catalytic site; other site
582899008015	Staphylococcal nuclease homologue; Region: SNase; pfam00565
582899008016	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
582899008017	Ferredoxin [Energy production and conversion]; Region: COG1146
582899008018	4Fe-4S binding domain; Region: Fer4; pfam00037
582899008019	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
582899008020	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582899008021	RNA binding surface [nucleotide binding]; other site
582899008022	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582899008023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899008024	ATP binding site [chemical binding]; other site
582899008025	putative Mg++ binding site [ion binding]; other site
582899008026	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582899008027	nucleotide binding region [chemical binding]; other site
582899008028	ATP-binding site [chemical binding]; other site
582899008029	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
582899008030	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
582899008031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
582899008032	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
582899008033	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
582899008034	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
582899008035	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
582899008036	metal ion-dependent adhesion site (MIDAS); other site
582899008037	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
582899008038	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
582899008039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
582899008040	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582899008041	HSP70 interaction site [polypeptide binding]; other site
582899008042	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
582899008043	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
582899008044	Domain of unknown function DUF21; Region: DUF21; pfam01595
582899008045	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582899008046	Transporter associated domain; Region: CorC_HlyC; smart01091
582899008047	shikimate kinase; Provisional; Region: PRK13946
582899008048	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
582899008049	ADP binding site [chemical binding]; other site
582899008050	magnesium binding site [ion binding]; other site
582899008051	putative shikimate binding site; other site
582899008052	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
582899008053	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
582899008054	active site
582899008055	dimer interface [polypeptide binding]; other site
582899008056	metal binding site [ion binding]; metal-binding site
582899008057	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
582899008058	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582899008059	active site
582899008060	DNA binding site [nucleotide binding]
582899008061	Int/Topo IB signature motif; other site
582899008062	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582899008063	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
582899008064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899008065	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
582899008066	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
582899008067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
582899008068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
582899008069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
582899008070	hypothetical protein; Provisional; Region: PRK05208
582899008071	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
582899008072	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
582899008073	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
582899008074	SEC-C motif; Region: SEC-C; pfam02810
582899008075	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
582899008076	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
582899008077	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
582899008078	heterotetramer interface [polypeptide binding]; other site
582899008079	active site pocket [active]
582899008080	cleavage site
582899008081	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
582899008082	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
582899008083	active site
582899008084	8-oxo-dGMP binding site [chemical binding]; other site
582899008085	nudix motif; other site
582899008086	metal binding site [ion binding]; metal-binding site
582899008087	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899008088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899008089	S-adenosylmethionine binding site [chemical binding]; other site
582899008090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
582899008091	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
582899008092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
582899008093	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
582899008094	GSH binding site [chemical binding]; other site
582899008095	catalytic residues [active]
582899008096	nitrilase; Region: PLN02798
582899008097	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
582899008098	putative active site [active]
582899008099	catalytic triad [active]
582899008100	dimer interface [polypeptide binding]; other site
582899008101	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
582899008102	biotin synthase; Region: bioB; TIGR00433
582899008103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899008104	FeS/SAM binding site; other site
582899008105	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
582899008106	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
582899008107	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
582899008108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582899008109	catalytic residue [active]
582899008110	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
582899008111	AAA domain; Region: AAA_26; pfam13500
582899008112	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
582899008113	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
582899008114	inhibitor-cofactor binding pocket; inhibition site
582899008115	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899008116	catalytic residue [active]
582899008117	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
582899008118	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582899008119	dimer interface [polypeptide binding]; other site
582899008120	active site
582899008121	CoA binding pocket [chemical binding]; other site
582899008122	YceI-like domain; Region: YceI; cl01001
582899008123	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
582899008124	Hemin uptake protein hemP; Region: hemP; pfam10636
582899008125	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899008126	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
582899008127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899008128	ATP binding site [chemical binding]; other site
582899008129	Mg2+ binding site [ion binding]; other site
582899008130	G-X-G motif; other site
582899008131	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582899008132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008133	active site
582899008134	phosphorylation site [posttranslational modification]
582899008135	intermolecular recognition site; other site
582899008136	dimerization interface [polypeptide binding]; other site
582899008137	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899008138	DNA binding site [nucleotide binding]
582899008139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899008140	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
582899008141	putative substrate translocation pore; other site
582899008142	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
582899008143	RNA/DNA hybrid binding site [nucleotide binding]; other site
582899008144	active site
582899008145	YGGT family; Region: YGGT; pfam02325
582899008146	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
582899008147	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
582899008148	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
582899008149	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
582899008150	homodimer interface [polypeptide binding]; other site
582899008151	NADP binding site [chemical binding]; other site
582899008152	substrate binding site [chemical binding]; other site
582899008153	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
582899008154	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
582899008155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899008156	Walker A motif; other site
582899008157	ATP binding site [chemical binding]; other site
582899008158	Walker B motif; other site
582899008159	arginine finger; other site
582899008160	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
582899008161	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
582899008162	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
582899008163	Beta protein; Region: Beta_protein; pfam14350
582899008164	glutathione synthetase; Provisional; Region: PRK05246
582899008165	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
582899008166	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
582899008167	primosome assembly protein PriA; Validated; Region: PRK05580
582899008168	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582899008169	ATP binding site [chemical binding]; other site
582899008170	putative Mg++ binding site [ion binding]; other site
582899008171	helicase superfamily c-terminal domain; Region: HELICc; smart00490
582899008172	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
582899008173	active site
582899008174	intersubunit interactions; other site
582899008175	catalytic residue [active]
582899008176	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
582899008177	FAD binding domain; Region: FAD_binding_4; pfam01565
582899008178	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
582899008179	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582899008180	active site
582899008181	DNA binding site [nucleotide binding]
582899008182	Int/Topo IB signature motif; other site
582899008183	TraB family; Region: TraB; cl12050
582899008184	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
582899008185	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899008186	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899008187	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899008188	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
582899008189	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582899008190	E3 interaction surface; other site
582899008191	lipoyl attachment site [posttranslational modification]; other site
582899008192	e3 binding domain; Region: E3_binding; pfam02817
582899008193	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
582899008194	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
582899008195	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
582899008196	TPP-binding site [chemical binding]; other site
582899008197	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
582899008198	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
582899008199	CoA binding domain; Region: CoA_binding; smart00881
582899008200	CoA-ligase; Region: Ligase_CoA; pfam00549
582899008201	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
582899008202	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
582899008203	CoA-ligase; Region: Ligase_CoA; pfam00549
582899008204	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
582899008205	malate dehydrogenase; Reviewed; Region: PRK06223
582899008206	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
582899008207	NAD(P) binding site [chemical binding]; other site
582899008208	dimer interface [polypeptide binding]; other site
582899008209	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582899008210	substrate binding site [chemical binding]; other site
582899008211	Predicted ATPase [General function prediction only]; Region: COG1485
582899008212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899008213	Coenzyme A binding pocket [chemical binding]; other site
582899008214	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
582899008215	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
582899008216	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
582899008217	L-aspartate oxidase; Provisional; Region: PRK06175
582899008218	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
582899008219	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
582899008220	putative SdhC subunit interface [polypeptide binding]; other site
582899008221	putative proximal heme binding site [chemical binding]; other site
582899008222	putative Iron-sulfur protein interface [polypeptide binding]; other site
582899008223	putative proximal quinone binding site; other site
582899008224	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
582899008225	Iron-sulfur protein interface; other site
582899008226	proximal quinone binding site [chemical binding]; other site
582899008227	SdhD (CybS) interface [polypeptide binding]; other site
582899008228	proximal heme binding site [chemical binding]; other site
582899008229	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
582899008230	putative active site [active]
582899008231	putative catalytic site [active]
582899008232	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
582899008233	putative active site [active]
582899008234	putative catalytic site [active]
582899008235	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
582899008236	pyridoxamine kinase; Validated; Region: PRK05756
582899008237	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
582899008238	dimer interface [polypeptide binding]; other site
582899008239	pyridoxal binding site [chemical binding]; other site
582899008240	ATP binding site [chemical binding]; other site
582899008241	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
582899008242	ArsC family; Region: ArsC; pfam03960
582899008243	catalytic residues [active]
582899008244	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
582899008245	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
582899008246	active site clefts [active]
582899008247	zinc binding site [ion binding]; other site
582899008248	dimer interface [polypeptide binding]; other site
582899008249	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
582899008250	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
582899008251	catalytic residues [active]
582899008252	central insert; other site
582899008253	Heme exporter protein D (CcmD); Region: CcmD; cl11475
582899008254	heme exporter protein CcmC; Region: ccmC; TIGR01191
582899008255	heme exporter protein CcmB; Region: ccmB; TIGR01190
582899008256	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
582899008257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
582899008258	Walker A/P-loop; other site
582899008259	ATP binding site [chemical binding]; other site
582899008260	Q-loop/lid; other site
582899008261	ABC transporter signature motif; other site
582899008262	Walker B; other site
582899008263	D-loop; other site
582899008264	H-loop/switch region; other site
582899008265	aconitate hydratase; Validated; Region: PRK09277
582899008266	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
582899008267	substrate binding site [chemical binding]; other site
582899008268	ligand binding site [chemical binding]; other site
582899008269	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
582899008270	substrate binding site [chemical binding]; other site
582899008271	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
582899008272	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
582899008273	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
582899008274	active site
582899008275	Zn binding site [ion binding]; other site
582899008276	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
582899008277	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
582899008278	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
582899008279	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
582899008280	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582899008281	FtsX-like permease family; Region: FtsX; pfam02687
582899008282	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
582899008283	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
582899008284	Walker A/P-loop; other site
582899008285	ATP binding site [chemical binding]; other site
582899008286	Q-loop/lid; other site
582899008287	ABC transporter signature motif; other site
582899008288	Walker B; other site
582899008289	D-loop; other site
582899008290	H-loop/switch region; other site
582899008291	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
582899008292	active site
582899008293	catalytic triad [active]
582899008294	oxyanion hole [active]
582899008295	switch loop; other site
582899008296	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
582899008297	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
582899008298	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
582899008299	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
582899008300	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
582899008301	NAD(P) binding site [chemical binding]; other site
582899008302	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
582899008303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
582899008304	Smr domain; Region: Smr; pfam01713
582899008305	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
582899008306	MltA specific insert domain; Region: MltA; smart00925
582899008307	3D domain; Region: 3D; pfam06725
582899008308	Tim44-like domain; Region: Tim44; pfam04280
582899008309	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
582899008310	Preprotein translocase subunit SecB; Region: SecB; pfam02556
582899008311	SecA binding site; other site
582899008312	Preprotein binding site; other site
582899008313	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
582899008314	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
582899008315	active site
582899008316	catalytic site [active]
582899008317	substrate binding site [chemical binding]; other site
582899008318	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
582899008319	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
582899008320	CoA-binding site [chemical binding]; other site
582899008321	ATP-binding [chemical binding]; other site
582899008322	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
582899008323	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
582899008324	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
582899008325	shikimate binding site; other site
582899008326	NAD(P) binding site [chemical binding]; other site
582899008327	Maf-like protein; Region: Maf; pfam02545
582899008328	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582899008329	active site
582899008330	dimer interface [polypeptide binding]; other site
582899008331	PEP synthetase regulatory protein; Provisional; Region: PRK05339
582899008332	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
582899008333	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
582899008334	substrate binding site [chemical binding]; other site
582899008335	active site
582899008336	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
582899008337	transcription termination factor Rho; Provisional; Region: rho; PRK09376
582899008338	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
582899008339	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
582899008340	RNA binding site [nucleotide binding]; other site
582899008341	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
582899008342	multimer interface [polypeptide binding]; other site
582899008343	Walker A motif; other site
582899008344	ATP binding site [chemical binding]; other site
582899008345	Walker B motif; other site
582899008346	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
582899008347	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
582899008348	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
582899008349	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
582899008350	catalytic residues [active]
582899008351	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
582899008352	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
582899008353	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
582899008354	trmE is a tRNA modification GTPase; Region: trmE; cd04164
582899008355	G1 box; other site
582899008356	GTP/Mg2+ binding site [chemical binding]; other site
582899008357	Switch I region; other site
582899008358	G2 box; other site
582899008359	Switch II region; other site
582899008360	G3 box; other site
582899008361	G4 box; other site
582899008362	G5 box; other site
582899008363	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
582899008364	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
582899008365	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
582899008366	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
582899008367	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
582899008368	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
582899008369	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582899008370	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899008371	P-loop; other site
582899008372	Magnesium ion binding site [ion binding]; other site
582899008373	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
582899008374	Magnesium ion binding site [ion binding]; other site
582899008375	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
582899008376	ParB-like nuclease domain; Region: ParB; smart00470
582899008377	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
582899008378	metal binding site [ion binding]; metal-binding site
582899008379	pantothenate kinase; Provisional; Region: PRK05439
582899008380	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
582899008381	ATP-binding site [chemical binding]; other site
582899008382	CoA-binding site [chemical binding]; other site
582899008383	Mg2+-binding site [ion binding]; other site
582899008384	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
582899008385	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
582899008386	substrate binding site [chemical binding]; other site
582899008387	ATP binding site [chemical binding]; other site
582899008388	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
582899008389	Lipopolysaccharide-assembly; Region: LptE; cl01125
582899008390	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
582899008391	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
582899008392	HIGH motif; other site
582899008393	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
582899008394	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899008395	active site
582899008396	KMSKS motif; other site
582899008397	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
582899008398	tRNA binding surface [nucleotide binding]; other site
582899008399	Fic family protein [Function unknown]; Region: COG3177
582899008400	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
582899008401	Fic/DOC family; Region: Fic; pfam02661
582899008402	Domain of unknown function (DUF336); Region: DUF336; pfam03928
582899008403	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
582899008404	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582899008405	catalytic residue [active]
582899008406	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
582899008407	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
582899008408	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
582899008409	active site
582899008410	catalytic tetrad [active]
582899008411	TIGR02594 family protein; Region: TIGR02594
582899008412	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
582899008413	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
582899008414	Helix-turn-helix domain; Region: HTH_18; pfam12833
582899008415	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
582899008416	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
582899008417	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
582899008418	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
582899008419	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
582899008420	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
582899008421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582899008422	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582899008423	ligand binding site [chemical binding]; other site
582899008424	flexible hinge region; other site
582899008425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008426	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
582899008427	active site
582899008428	phosphorylation site [posttranslational modification]
582899008429	intermolecular recognition site; other site
582899008430	dimerization interface [polypeptide binding]; other site
582899008431	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
582899008432	DNA binding site [nucleotide binding]
582899008433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
582899008434	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
582899008435	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
582899008436	Nitrogen regulatory protein P-II; Region: P-II; smart00938
582899008437	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
582899008438	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
582899008439	active site
582899008440	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
582899008441	catalytic triad [active]
582899008442	dimer interface [polypeptide binding]; other site
582899008443	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
582899008444	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
582899008445	RimM N-terminal domain; Region: RimM; pfam01782
582899008446	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
582899008447	PRC-barrel domain; Region: PRC; pfam05239
582899008448	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
582899008449	signal recognition particle protein; Provisional; Region: PRK10867
582899008450	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
582899008451	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582899008452	P loop; other site
582899008453	GTP binding site [chemical binding]; other site
582899008454	Signal peptide binding domain; Region: SRP_SPB; pfam02978
582899008455	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
582899008456	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
582899008457	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
582899008458	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
582899008459	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
582899008460	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582899008461	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899008462	FeS/SAM binding site; other site
582899008463	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
582899008464	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
582899008465	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582899008466	P loop; other site
582899008467	GTP binding site [chemical binding]; other site
582899008468	Intracellular septation protein A; Region: IspA; pfam04279
582899008469	Intracellular septation protein A; Region: IspA; pfam04279
582899008470	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
582899008471	MarR family; Region: MarR_2; pfam12802
582899008472	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
582899008473	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
582899008474	tartrate dehydrogenase; Region: TTC; TIGR02089
582899008475	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
582899008476	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
582899008477	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582899008478	catalytic core [active]
582899008479	dihydrodipicolinate reductase; Provisional; Region: PRK00048
582899008480	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
582899008481	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
582899008482	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
582899008483	substrate binding site [chemical binding]; other site
582899008484	metal binding sites [ion binding]; metal-binding site
582899008485	dimer interface [polypeptide binding]; other site
582899008486	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
582899008487	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582899008488	Coenzyme A binding pocket [chemical binding]; other site
582899008489	Phasin protein; Region: Phasin_2; cl11491
582899008490	PIF1-like helicase; Region: PIF1; pfam05970
582899008491	AAA domain; Region: AAA_30; pfam13604
582899008492	Helicase; Region: Herpes_Helicase; pfam02689
582899008493	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
582899008494	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
582899008495	G1 box; other site
582899008496	putative GEF interaction site [polypeptide binding]; other site
582899008497	GTP/Mg2+ binding site [chemical binding]; other site
582899008498	Switch I region; other site
582899008499	G2 box; other site
582899008500	G3 box; other site
582899008501	Switch II region; other site
582899008502	G4 box; other site
582899008503	G5 box; other site
582899008504	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
582899008505	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
582899008506	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
582899008507	Peptidase family M50; Region: Peptidase_M50; pfam02163
582899008508	active site
582899008509	putative substrate binding region [chemical binding]; other site
582899008510	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
582899008511	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
582899008512	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
582899008513	putative active site; other site
582899008514	catalytic triad [active]
582899008515	putative dimer interface [polypeptide binding]; other site
582899008516	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
582899008517	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
582899008518	argininosuccinate synthase; Provisional; Region: PRK13820
582899008519	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
582899008520	ANP binding site [chemical binding]; other site
582899008521	Substrate Binding Site II [chemical binding]; other site
582899008522	Substrate Binding Site I [chemical binding]; other site
582899008523	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
582899008524	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899008525	FeS/SAM binding site; other site
582899008526	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
582899008527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899008528	Walker A motif; other site
582899008529	ATP binding site [chemical binding]; other site
582899008530	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
582899008531	Walker B motif; other site
582899008532	arginine finger; other site
582899008533	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
582899008534	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
582899008535	active site
582899008536	HslU subunit interaction site [polypeptide binding]; other site
582899008537	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
582899008538	putative active site pocket [active]
582899008539	4-fold oligomerization interface [polypeptide binding]; other site
582899008540	metal binding residues [ion binding]; metal-binding site
582899008541	3-fold/trimer interface [polypeptide binding]; other site
582899008542	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
582899008543	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
582899008544	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
582899008545	putative active site [active]
582899008546	oxyanion strand; other site
582899008547	catalytic triad [active]
582899008548	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
582899008549	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
582899008550	catalytic residues [active]
582899008551	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
582899008552	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
582899008553	G1 box; other site
582899008554	putative GEF interaction site [polypeptide binding]; other site
582899008555	GTP/Mg2+ binding site [chemical binding]; other site
582899008556	Switch I region; other site
582899008557	G2 box; other site
582899008558	G3 box; other site
582899008559	Switch II region; other site
582899008560	G4 box; other site
582899008561	G5 box; other site
582899008562	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
582899008563	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
582899008564	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
582899008565	substrate binding site [chemical binding]; other site
582899008566	glutamase interaction surface [polypeptide binding]; other site
582899008567	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
582899008568	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582899008569	minor groove reading motif; other site
582899008570	helix-hairpin-helix signature motif; other site
582899008571	substrate binding pocket [chemical binding]; other site
582899008572	active site
582899008573	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
582899008574	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
582899008575	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
582899008576	dimer interface [polypeptide binding]; other site
582899008577	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899008578	active site
582899008579	metal binding site [ion binding]; metal-binding site
582899008580	glutathione binding site [chemical binding]; other site
582899008581	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
582899008582	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
582899008583	substrate binding site [chemical binding]; other site
582899008584	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
582899008585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899008586	Methyltransferase domain; Region: Methyltransf_23; pfam13489
582899008587	Autoinducer synthetase; Region: Autoind_synth; cl17404
582899008588	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582899008589	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582899008590	substrate binding site [chemical binding]; other site
582899008591	ligand binding site [chemical binding]; other site
582899008592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582899008593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
582899008594	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582899008595	putative effector binding pocket; other site
582899008596	dimerization interface [polypeptide binding]; other site
582899008597	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
582899008598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
582899008599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899008600	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
582899008601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582899008602	putative substrate translocation pore; other site
582899008603	hypothetical protein; Reviewed; Region: PRK00024
582899008604	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
582899008605	MPN+ (JAMM) motif; other site
582899008606	Zinc-binding site [ion binding]; other site
582899008607	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
582899008608	active site
582899008609	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582899008610	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
582899008611	ligand binding site [chemical binding]; other site
582899008612	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
582899008613	Uncharacterized conserved protein [Function unknown]; Region: COG3743
582899008614	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582899008615	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
582899008616	Uncharacterized conserved protein [Function unknown]; Region: COG5470
582899008617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
582899008618	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
582899008619	active site
582899008620	dimer interface [polypeptide binding]; other site
582899008621	Predicted flavoprotein [General function prediction only]; Region: COG0431
582899008622	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
582899008623	chaperone protein DnaJ; Provisional; Region: PRK10767
582899008624	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
582899008625	HSP70 interaction site [polypeptide binding]; other site
582899008626	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
582899008627	substrate binding site [polypeptide binding]; other site
582899008628	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
582899008629	Zn binding sites [ion binding]; other site
582899008630	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
582899008631	dimer interface [polypeptide binding]; other site
582899008632	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
582899008633	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
582899008634	nucleotide binding site [chemical binding]; other site
582899008635	NEF interaction site [polypeptide binding]; other site
582899008636	SBD interface [polypeptide binding]; other site
582899008637	heat shock protein GrpE; Provisional; Region: PRK14141
582899008638	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
582899008639	dimer interface [polypeptide binding]; other site
582899008640	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
582899008641	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
582899008642	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
582899008643	ribonuclease PH; Reviewed; Region: rph; PRK00173
582899008644	Ribonuclease PH; Region: RNase_PH_bact; cd11362
582899008645	hexamer interface [polypeptide binding]; other site
582899008646	active site
582899008647	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
582899008648	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
582899008649	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
582899008650	putative metal binding site [ion binding]; other site
582899008651	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
582899008652	active site
582899008653	dimerization interface [polypeptide binding]; other site
582899008654	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
582899008655	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899008656	FeS/SAM binding site; other site
582899008657	HemN C-terminal domain; Region: HemN_C; pfam06969
582899008658	Caspase 8-associated protein 2 myb-like domain; Region: CASP8AP2; cd12202
582899008659	Predicted membrane protein [Function unknown]; Region: COG1238
582899008660	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
582899008661	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
582899008662	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
582899008663	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
582899008664	active site
582899008665	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582899008666	active site
582899008667	HIGH motif; other site
582899008668	nucleotide binding site [chemical binding]; other site
582899008669	active site
582899008670	KMSKS motif; other site
582899008671	Predicted methyltransferases [General function prediction only]; Region: COG0313
582899008672	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
582899008673	putative SAM binding site [chemical binding]; other site
582899008674	putative homodimer interface [polypeptide binding]; other site
582899008675	hypothetical protein; Reviewed; Region: PRK12497
582899008676	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
582899008677	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
582899008678	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
582899008679	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582899008680	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
582899008681	beta subunit interaction interface [polypeptide binding]; other site
582899008682	Walker A motif; other site
582899008683	ATP binding site [chemical binding]; other site
582899008684	Walker B motif; other site
582899008685	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582899008686	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
582899008687	core domain interface [polypeptide binding]; other site
582899008688	delta subunit interface [polypeptide binding]; other site
582899008689	epsilon subunit interface [polypeptide binding]; other site
582899008690	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
582899008691	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
582899008692	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582899008693	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
582899008694	alpha subunit interaction interface [polypeptide binding]; other site
582899008695	Walker A motif; other site
582899008696	ATP binding site [chemical binding]; other site
582899008697	Walker B motif; other site
582899008698	inhibitor binding site; inhibition site
582899008699	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582899008700	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
582899008701	gamma subunit interface [polypeptide binding]; other site
582899008702	epsilon subunit interface [polypeptide binding]; other site
582899008703	LBP interface [polypeptide binding]; other site
582899008704	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
582899008705	putative active site [active]
582899008706	Ap4A binding site [chemical binding]; other site
582899008707	nudix motif; other site
582899008708	putative metal binding site [ion binding]; other site
582899008709	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
582899008710	putative active site [active]
582899008711	Ap4A binding site [chemical binding]; other site
582899008712	nudix motif; other site
582899008713	putative metal binding site [ion binding]; other site
582899008714	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
582899008715	C-terminal peptidase (prc); Region: prc; TIGR00225
582899008716	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
582899008717	protein binding site [polypeptide binding]; other site
582899008718	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
582899008719	Catalytic dyad [active]
582899008720	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
582899008721	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
582899008722	Peptidase family M23; Region: Peptidase_M23; pfam01551
582899008723	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
582899008724	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
582899008725	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582899008726	Ligand binding site [chemical binding]; other site
582899008727	Electron transfer flavoprotein domain; Region: ETF; pfam01012
582899008728	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582899008729	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582899008730	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
582899008731	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
582899008732	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
582899008733	Double zinc ribbon; Region: DZR; pfam12773
582899008734	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
582899008735	classical (c) SDRs; Region: SDR_c; cd05233
582899008736	NAD(P) binding site [chemical binding]; other site
582899008737	active site
582899008738	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
582899008739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
582899008740	motif II; other site
582899008741	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
582899008742	feedback inhibition sensing region; other site
582899008743	homohexameric interface [polypeptide binding]; other site
582899008744	nucleotide binding site [chemical binding]; other site
582899008745	N-acetyl-L-glutamate binding site [chemical binding]; other site
582899008746	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
582899008747	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
582899008748	G1 box; other site
582899008749	GTP/Mg2+ binding site [chemical binding]; other site
582899008750	Switch I region; other site
582899008751	G2 box; other site
582899008752	G3 box; other site
582899008753	Switch II region; other site
582899008754	G4 box; other site
582899008755	G5 box; other site
582899008756	membrane protein insertase; Provisional; Region: PRK01318
582899008757	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
582899008758	Ribonuclease P; Region: Ribonuclease_P; cl00457
582899008759	mercuric reductase; Validated; Region: PRK06370
582899008760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
582899008761	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582899008762	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899008763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899008764	ATP binding site [chemical binding]; other site
582899008765	Mg2+ binding site [ion binding]; other site
582899008766	G-X-G motif; other site
582899008767	Protein of unknown function, DUF; Region: DUF411; cl01142
582899008768	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
582899008769	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
582899008770	active site residue [active]
582899008771	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
582899008772	active site residue [active]
582899008773	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
582899008774	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
582899008775	dimer interface [polypeptide binding]; other site
582899008776	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899008777	catalytic residue [active]
582899008778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899008779	HAMP domain; Region: HAMP; pfam00672
582899008780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899008781	dimer interface [polypeptide binding]; other site
582899008782	phosphorylation site [posttranslational modification]
582899008783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899008784	ATP binding site [chemical binding]; other site
582899008785	Mg2+ binding site [ion binding]; other site
582899008786	G-X-G motif; other site
582899008787	Response regulator receiver domain; Region: Response_reg; pfam00072
582899008788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008789	active site
582899008790	phosphorylation site [posttranslational modification]
582899008791	intermolecular recognition site; other site
582899008792	dimerization interface [polypeptide binding]; other site
582899008793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582899008794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008795	active site
582899008796	phosphorylation site [posttranslational modification]
582899008797	intermolecular recognition site; other site
582899008798	dimerization interface [polypeptide binding]; other site
582899008799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
582899008800	DNA binding residues [nucleotide binding]
582899008801	dimerization interface [polypeptide binding]; other site
582899008802	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899008803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008804	active site
582899008805	phosphorylation site [posttranslational modification]
582899008806	intermolecular recognition site; other site
582899008807	dimerization interface [polypeptide binding]; other site
582899008808	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
582899008809	PAS fold; Region: PAS_4; pfam08448
582899008810	PAS domain S-box; Region: sensory_box; TIGR00229
582899008811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899008812	putative active site [active]
582899008813	heme pocket [chemical binding]; other site
582899008814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582899008815	HWE histidine kinase; Region: HWE_HK; pfam07536
582899008816	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
582899008817	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899008818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008819	active site
582899008820	phosphorylation site [posttranslational modification]
582899008821	intermolecular recognition site; other site
582899008822	dimerization interface [polypeptide binding]; other site
582899008823	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
582899008824	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582899008825	dimer interface [polypeptide binding]; other site
582899008826	active site
582899008827	CoA binding pocket [chemical binding]; other site
582899008828	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582899008829	classical (c) SDRs; Region: SDR_c; cd05233
582899008830	NAD(P) binding site [chemical binding]; other site
582899008831	active site
582899008832	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
582899008833	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
582899008834	ligand binding site [chemical binding]; other site
582899008835	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582899008836	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582899008837	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
582899008838	HlyD family secretion protein; Region: HlyD_3; pfam13437
582899008839	Caspase domain; Region: Peptidase_C14; pfam00656
582899008840	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
582899008841	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
582899008842	HemY protein N-terminus; Region: HemY_N; pfam07219
582899008843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
582899008844	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
582899008845	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
582899008846	active site
582899008847	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
582899008848	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
582899008849	domain interfaces; other site
582899008850	active site
582899008851	UGMP family protein; Validated; Region: PRK09604
582899008852	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
582899008853	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
582899008854	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
582899008855	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
582899008856	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
582899008857	EVE domain; Region: EVE; cl00728
582899008858	Predicted methyltransferase [General function prediction only]; Region: COG3897
582899008859	acetyl-CoA synthetase; Provisional; Region: PRK00174
582899008860	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
582899008861	active site
582899008862	CoA binding site [chemical binding]; other site
582899008863	acyl-activating enzyme (AAE) consensus motif; other site
582899008864	AMP binding site [chemical binding]; other site
582899008865	acetate binding site [chemical binding]; other site
582899008866	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
582899008867	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
582899008868	Peptidase family M48; Region: Peptidase_M48; cl12018
582899008869	NusB family; Region: NusB; pfam01029
582899008870	putative RNA binding site [nucleotide binding]; other site
582899008871	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
582899008872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899008873	S-adenosylmethionine binding site [chemical binding]; other site
582899008874	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
582899008875	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
582899008876	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
582899008877	purine monophosphate binding site [chemical binding]; other site
582899008878	dimer interface [polypeptide binding]; other site
582899008879	putative catalytic residues [active]
582899008880	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
582899008881	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
582899008882	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
582899008883	Predicted membrane protein [Function unknown]; Region: COG3762
582899008884	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
582899008885	Repair protein; Region: Repair_PSII; pfam04536
582899008886	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
582899008887	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
582899008888	putative deacylase active site [active]
582899008889	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
582899008890	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
582899008891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
582899008892	TPR motif; other site
582899008893	binding surface
582899008894	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
582899008895	Uncharacterized conserved protein [Function unknown]; Region: COG2835
582899008896	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
582899008897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582899008898	putative active site [active]
582899008899	heme pocket [chemical binding]; other site
582899008900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899008901	dimer interface [polypeptide binding]; other site
582899008902	phosphorylation site [posttranslational modification]
582899008903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899008904	ATP binding site [chemical binding]; other site
582899008905	Mg2+ binding site [ion binding]; other site
582899008906	G-X-G motif; other site
582899008907	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582899008908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
582899008909	active site
582899008910	phosphorylation site [posttranslational modification]
582899008911	intermolecular recognition site; other site
582899008912	dimerization interface [polypeptide binding]; other site
582899008913	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
582899008914	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
582899008915	MutS domain I; Region: MutS_I; pfam01624
582899008916	MutS domain II; Region: MutS_II; pfam05188
582899008917	MutS domain III; Region: MutS_III; pfam05192
582899008918	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
582899008919	Walker A/P-loop; other site
582899008920	ATP binding site [chemical binding]; other site
582899008921	Q-loop/lid; other site
582899008922	ABC transporter signature motif; other site
582899008923	Walker B; other site
582899008924	D-loop; other site
582899008925	H-loop/switch region; other site
582899008926	PII uridylyl-transferase; Provisional; Region: PRK05092
582899008927	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582899008928	metal binding triad; other site
582899008929	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582899008930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582899008931	Zn2+ binding site [ion binding]; other site
582899008932	Mg2+ binding site [ion binding]; other site
582899008933	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
582899008934	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
582899008935	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
582899008936	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
582899008937	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
582899008938	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
582899008939	active site
582899008940	HIGH motif; other site
582899008941	dimer interface [polypeptide binding]; other site
582899008942	KMSKS motif; other site
582899008943	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
582899008944	Ligand Binding Site [chemical binding]; other site
582899008945	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
582899008946	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
582899008947	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
582899008948	putative FMN binding site [chemical binding]; other site
582899008949	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
582899008950	Glycoprotease family; Region: Peptidase_M22; pfam00814
582899008951	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
582899008952	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
582899008953	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582899008954	metal binding site 2 [ion binding]; metal-binding site
582899008955	putative DNA binding helix; other site
582899008956	metal binding site 1 [ion binding]; metal-binding site
582899008957	dimer interface [polypeptide binding]; other site
582899008958	structural Zn2+ binding site [ion binding]; other site
582899008959	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582899008960	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582899008961	putative acyl-acceptor binding pocket; other site
582899008962	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
582899008963	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582899008964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
582899008965	FeS/SAM binding site; other site
582899008966	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
582899008967	PhoH-like protein; Region: PhoH; pfam02562
582899008968	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
582899008969	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
582899008970	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582899008971	Transporter associated domain; Region: CorC_HlyC; smart01091
582899008972	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
582899008973	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
582899008974	putative active site [active]
582899008975	catalytic triad [active]
582899008976	putative dimer interface [polypeptide binding]; other site
582899008977	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
582899008978	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582899008979	non-specific DNA binding site [nucleotide binding]; other site
582899008980	salt bridge; other site
582899008981	sequence-specific DNA binding site [nucleotide binding]; other site
582899008982	S-adenosylmethionine synthetase; Validated; Region: PRK05250
582899008983	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
582899008984	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
582899008985	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
582899008986	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
582899008987	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
582899008988	Sm and related proteins; Region: Sm_like; cl00259
582899008989	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
582899008990	putative oligomer interface [polypeptide binding]; other site
582899008991	putative RNA binding site [nucleotide binding]; other site
582899008992	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
582899008993	NusA N-terminal domain; Region: NusA_N; pfam08529
582899008994	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
582899008995	RNA binding site [nucleotide binding]; other site
582899008996	homodimer interface [polypeptide binding]; other site
582899008997	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
582899008998	G-X-X-G motif; other site
582899008999	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
582899009000	G-X-X-G motif; other site
582899009001	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
582899009002	hypothetical protein; Provisional; Region: PRK09190
582899009003	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
582899009004	putative RNA binding cleft [nucleotide binding]; other site
582899009005	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
582899009006	translation initiation factor IF-2; Validated; Region: infB; PRK05306
582899009007	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
582899009008	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
582899009009	G1 box; other site
582899009010	putative GEF interaction site [polypeptide binding]; other site
582899009011	GTP/Mg2+ binding site [chemical binding]; other site
582899009012	Switch I region; other site
582899009013	G2 box; other site
582899009014	G3 box; other site
582899009015	Switch II region; other site
582899009016	G4 box; other site
582899009017	G5 box; other site
582899009018	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
582899009019	Translation-initiation factor 2; Region: IF-2; pfam11987
582899009020	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
582899009021	YcxB-like protein; Region: YcxB; pfam14317
582899009022	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
582899009023	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
582899009024	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
582899009025	RNA binding site [nucleotide binding]; other site
582899009026	active site
582899009027	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
582899009028	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
582899009029	16S/18S rRNA binding site [nucleotide binding]; other site
582899009030	S13e-L30e interaction site [polypeptide binding]; other site
582899009031	25S rRNA binding site [nucleotide binding]; other site
582899009032	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
582899009033	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
582899009034	RNase E interface [polypeptide binding]; other site
582899009035	trimer interface [polypeptide binding]; other site
582899009036	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
582899009037	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
582899009038	RNase E interface [polypeptide binding]; other site
582899009039	trimer interface [polypeptide binding]; other site
582899009040	active site
582899009041	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
582899009042	putative nucleic acid binding region [nucleotide binding]; other site
582899009043	G-X-X-G motif; other site
582899009044	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
582899009045	RNA binding site [nucleotide binding]; other site
582899009046	domain interface; other site
582899009047	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
582899009048	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
582899009049	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
582899009050	NAD binding site [chemical binding]; other site
582899009051	homotetramer interface [polypeptide binding]; other site
582899009052	homodimer interface [polypeptide binding]; other site
582899009053	substrate binding site [chemical binding]; other site
582899009054	active site
582899009055	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
582899009056	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582899009057	dimer interface [polypeptide binding]; other site
582899009058	active site
582899009059	3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174
582899009060	active site 2 [active]
582899009061	active site 1 [active]
582899009062	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582899009063	metal binding site 2 [ion binding]; metal-binding site
582899009064	putative DNA binding helix; other site
582899009065	metal binding site 1 [ion binding]; metal-binding site
582899009066	dimer interface [polypeptide binding]; other site
582899009067	structural Zn2+ binding site [ion binding]; other site
582899009068	Bacterial SH3 domain; Region: SH3_4; pfam06347
582899009069	Bacterial SH3 domain; Region: SH3_4; pfam06347
582899009070	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
582899009071	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
582899009072	dimerization interface [polypeptide binding]; other site
582899009073	ligand binding site [chemical binding]; other site
582899009074	NADP binding site [chemical binding]; other site
582899009075	catalytic site [active]
582899009076	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
582899009077	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
582899009078	ATP binding site [chemical binding]; other site
582899009079	substrate interface [chemical binding]; other site
582899009080	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
582899009081	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
582899009082	dimer interface [polypeptide binding]; other site
582899009083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582899009084	catalytic residue [active]
582899009085	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
582899009086	trimer interface [polypeptide binding]; other site
582899009087	active site
582899009088	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
582899009089	Flavoprotein; Region: Flavoprotein; pfam02441
582899009090	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
582899009091	Protein of unknown function (DUF461); Region: DUF461; pfam04314
582899009092	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
582899009093	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
582899009094	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
582899009095	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582899009096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
582899009097	dimer interface [polypeptide binding]; other site
582899009098	phosphorylation site [posttranslational modification]
582899009099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582899009100	ATP binding site [chemical binding]; other site
582899009101	Mg2+ binding site [ion binding]; other site
582899009102	G-X-G motif; other site
582899009103	Predicted integral membrane protein [Function unknown]; Region: COG0392
582899009104	Uncharacterized conserved protein [Function unknown]; Region: COG2898
582899009105	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
582899009106	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
582899009107	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
582899009108	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582899009109	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
582899009110	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
582899009111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899009112	S-adenosylmethionine binding site [chemical binding]; other site
582899009113	aspartate kinase; Reviewed; Region: PRK06635
582899009114	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
582899009115	putative nucleotide binding site [chemical binding]; other site
582899009116	putative catalytic residues [active]
582899009117	putative Mg ion binding site [ion binding]; other site
582899009118	putative aspartate binding site [chemical binding]; other site
582899009119	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
582899009120	putative allosteric regulatory site; other site
582899009121	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
582899009122	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
582899009123	GAF domain; Region: GAF; pfam01590
582899009124	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
582899009125	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
582899009126	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
582899009127	Helix-turn-helix domain; Region: HTH_25; pfam13413
582899009128	peptide chain release factor 1; Validated; Region: prfA; PRK00591
582899009129	This domain is found in peptide chain release factors; Region: PCRF; smart00937
582899009130	RF-1 domain; Region: RF-1; pfam00472
582899009131	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
582899009132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899009133	S-adenosylmethionine binding site [chemical binding]; other site
582899009134	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
582899009135	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
582899009136	Clp amino terminal domain; Region: Clp_N; pfam02861
582899009137	Clp amino terminal domain; Region: Clp_N; pfam02861
582899009138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899009139	Walker A motif; other site
582899009140	ATP binding site [chemical binding]; other site
582899009141	Walker B motif; other site
582899009142	arginine finger; other site
582899009143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
582899009144	Walker A motif; other site
582899009145	ATP binding site [chemical binding]; other site
582899009146	Walker B motif; other site
582899009147	arginine finger; other site
582899009148	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582899009149	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
582899009150	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
582899009151	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
582899009152	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582899009153	Peptidase family M23; Region: Peptidase_M23; pfam01551
582899009154	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
582899009155	Iron permease FTR1 family; Region: FTR1; cl00475
582899009156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
582899009157	SnoaL-like domain; Region: SnoaL_2; pfam12680
582899009158	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
582899009159	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
582899009160	ABC1 family; Region: ABC1; cl17513
582899009161	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
582899009162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
582899009163	S-adenosylmethionine binding site [chemical binding]; other site
582899009164	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
582899009165	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
582899009166	DNA binding site [nucleotide binding]
582899009167	catalytic residue [active]
582899009168	H2TH interface [polypeptide binding]; other site
582899009169	putative catalytic residues [active]
582899009170	turnover-facilitating residue; other site
582899009171	intercalation triad [nucleotide binding]; other site
582899009172	8OG recognition residue [nucleotide binding]; other site
582899009173	putative reading head residues; other site
582899009174	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
582899009175	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
582899009176	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239