-- dump date 20111121_012617 -- class Genbank::misc_feature -- table misc_feature_note -- id note 717785000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 717785000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785000003 Walker A motif; other site 717785000004 ATP binding site [chemical binding]; other site 717785000005 Walker B motif; other site 717785000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 717785000007 DnaA box-binding interface [nucleotide binding]; other site 717785000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 717785000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 717785000010 putative DNA binding surface [nucleotide binding]; other site 717785000011 dimer interface [polypeptide binding]; other site 717785000012 beta-clamp/clamp loader binding surface; other site 717785000013 beta-clamp/translesion DNA polymerase binding surface; other site 717785000014 recombination protein F; Reviewed; Region: recF; PRK00064 717785000015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000016 Walker A/P-loop; other site 717785000017 ATP binding site [chemical binding]; other site 717785000018 Q-loop/lid; other site 717785000019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000020 ABC transporter signature motif; other site 717785000021 Walker B; other site 717785000022 D-loop; other site 717785000023 H-loop/switch region; other site 717785000024 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 717785000025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717785000026 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 717785000027 anchoring element; other site 717785000028 dimer interface [polypeptide binding]; other site 717785000029 ATP binding site [chemical binding]; other site 717785000030 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 717785000031 active site 717785000032 putative metal-binding site [ion binding]; other site 717785000033 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717785000034 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 717785000035 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 717785000036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785000037 Transglycosylase; Region: Transgly; cl07896 717785000038 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 717785000039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785000040 Protein of unknown function DUF45; Region: DUF45; cl00636 717785000041 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 717785000042 Cu(I) binding site [ion binding]; other site 717785000043 MAPEG family; Region: MAPEG; cl09190 717785000044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785000045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785000046 ATP binding site [chemical binding]; other site 717785000047 Mg2+ binding site [ion binding]; other site 717785000048 G-X-G motif; other site 717785000049 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 717785000050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785000051 active site 717785000052 phosphorylation site [posttranslational modification] 717785000053 intermolecular recognition site; other site 717785000054 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 717785000055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785000056 Walker A motif; other site 717785000057 ATP binding site [chemical binding]; other site 717785000058 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 717785000059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000060 Active site [active] 717785000061 GcrA cell cycle regulator; Region: GcrA; cl11564 717785000062 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 717785000063 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785000064 inhibitor-cofactor binding pocket; inhibition site 717785000065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000066 catalytic residue [active] 717785000067 ornithine carbamoyltransferase; Provisional; Region: PRK00779 717785000068 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785000069 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785000070 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 717785000071 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 717785000072 dimerization interface [polypeptide binding]; other site 717785000073 domain crossover interface; other site 717785000074 redox-dependent activation switch; other site 717785000075 Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591 717785000076 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 717785000077 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 717785000078 metal binding site [ion binding]; metal-binding site 717785000079 putative dimer interface [polypeptide binding]; other site 717785000080 Protein of unknown function (DUF525); Region: DUF525; cl01119 717785000081 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 717785000082 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785000083 homodimer interface [polypeptide binding]; other site 717785000084 substrate-cofactor binding pocket; other site 717785000085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000086 catalytic residue [active] 717785000087 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 717785000088 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 717785000089 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 717785000090 trimer interface [polypeptide binding]; other site 717785000091 active site 717785000092 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 717785000093 trimer interface [polypeptide binding]; other site 717785000094 active site 717785000095 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 717785000096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785000097 dimerization interface [polypeptide binding]; other site 717785000098 putative DNA binding site [nucleotide binding]; other site 717785000099 putative Zn2+ binding site [ion binding]; other site 717785000100 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 717785000101 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 717785000102 NADP binding site [chemical binding]; other site 717785000103 homodimer interface [polypeptide binding]; other site 717785000104 active site 717785000105 substrate binding site [chemical binding]; other site 717785000106 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 717785000107 IHF - DNA interface [nucleotide binding]; other site 717785000108 IHF dimer interface [polypeptide binding]; other site 717785000109 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 717785000110 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 717785000111 metal binding site [ion binding]; metal-binding site 717785000112 dimer interface [polypeptide binding]; other site 717785000113 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 717785000114 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 717785000115 trimer interface [polypeptide binding]; other site 717785000116 active site 717785000117 substrate binding site [chemical binding]; other site 717785000118 CoA binding site [chemical binding]; other site 717785000119 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785000120 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 717785000121 catalytic residues [active] 717785000122 argininosuccinate lyase; Provisional; Region: PRK00855 717785000123 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 717785000124 active sites [active] 717785000125 tetramer interface [polypeptide binding]; other site 717785000126 diaminopimelate decarboxylase; Region: lysA; TIGR01048 717785000127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 717785000128 active site 717785000129 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785000130 substrate binding site [chemical binding]; other site 717785000131 catalytic residues [active] 717785000132 dimer interface [polypeptide binding]; other site 717785000133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785000134 PAS fold; Region: PAS_4; pfam08448 717785000135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785000136 putative active site [active] 717785000137 heme pocket [chemical binding]; other site 717785000138 TIGR02302 family protein; Region: aProt_lowcomp 717785000139 TIGR02302 family protein; Region: aProt_lowcomp 717785000140 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785000141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000142 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 717785000143 dimerization interface [polypeptide binding]; other site 717785000144 substrate binding pocket [chemical binding]; other site 717785000145 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 717785000146 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 717785000147 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 717785000148 Transglycosylase; Region: Transgly; cl07896 717785000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785000150 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 717785000151 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 717785000152 MG2 domain; Region: A2M_N; pfam01835 717785000153 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 717785000154 Alpha-2-macroglobulin family; Region: A2M; pfam00207 717785000155 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 717785000156 surface patch; other site 717785000157 thioester region; other site 717785000158 specificity defining residues; other site 717785000159 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 717785000160 Transglycosylase; Region: Transgly; cl07896 717785000161 Domain of unknown function DUF87; Region: DUF87; pfam01935 717785000162 AAA-like domain; Region: AAA_10; pfam12846 717785000163 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 717785000164 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717785000165 Beta-lactamase; Region: Beta-lactamase; cl01009 717785000166 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785000167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000168 putative substrate translocation pore; other site 717785000169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785000170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 717785000171 active site 717785000172 catalytic tetrad [active] 717785000173 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 717785000174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785000175 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 717785000176 dimer interface [polypeptide binding]; other site 717785000177 active site 717785000178 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 717785000179 lytic murein transglycosylase; Region: MltB_2; TIGR02283 717785000180 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 717785000181 active site 717785000182 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785000183 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785000184 N-terminal plug; other site 717785000185 ligand-binding site [chemical binding]; other site 717785000186 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785000187 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000188 ligand binding site [chemical binding]; other site 717785000189 flexible hinge region; other site 717785000190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000191 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 717785000192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785000193 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 717785000194 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 717785000195 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 717785000196 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 717785000197 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 717785000198 active site 717785000199 TDP-binding site; other site 717785000200 acceptor substrate-binding pocket; other site 717785000201 homodimer interface [polypeptide binding]; other site 717785000202 Cupin domain; Region: Cupin_2; cl09118 717785000203 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 717785000204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000205 metabolite-proton symporter; Region: 2A0106; TIGR00883 717785000206 putative substrate translocation pore; other site 717785000207 Protein of unknown function (DUF640); Region: DUF640; pfam04852 717785000208 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 717785000209 active site 717785000210 catalytic residues [active] 717785000211 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 717785000212 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 717785000213 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 717785000214 B12 binding site [chemical binding]; other site 717785000215 cobalt ligand [ion binding]; other site 717785000216 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 717785000217 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 717785000218 NAD(P) binding site [chemical binding]; other site 717785000219 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 717785000220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785000221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785000222 active site 717785000223 META domain; Region: META; cl01245 717785000224 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785000225 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785000226 NADP binding site [chemical binding]; other site 717785000227 active site 717785000228 steroid binding site; other site 717785000229 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 717785000230 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 717785000231 Domain of unknown function DUF143; Region: DUF143; cl00519 717785000232 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 717785000233 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 717785000234 active site 717785000235 (T/H)XGH motif; other site 717785000236 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 717785000237 putative catalytic cysteine [active] 717785000238 gamma-glutamyl kinase; Provisional; Region: PRK05429 717785000239 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 717785000240 nucleotide binding site [chemical binding]; other site 717785000241 homotetrameric interface [polypeptide binding]; other site 717785000242 putative phosphate binding site [ion binding]; other site 717785000243 putative allosteric binding site; other site 717785000244 PUA domain; Region: PUA; cl00607 717785000245 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 717785000246 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717785000247 GTPase CgtA; Reviewed; Region: obgE; PRK12299 717785000248 GTP1/OBG; Region: GTP1_OBG; pfam01018 717785000249 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 717785000250 G1 box; other site 717785000251 GTP/Mg2+ binding site [chemical binding]; other site 717785000252 Switch I region; other site 717785000253 G2 box; other site 717785000254 G3 box; other site 717785000255 Switch II region; other site 717785000256 G4 box; other site 717785000257 G5 box; other site 717785000258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785000259 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 717785000260 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 717785000261 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 717785000262 TIR domain; Region: TIR; cl02060 717785000263 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 717785000264 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 717785000265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000266 ABC transporter signature motif; other site 717785000267 Walker B; other site 717785000268 D-loop; other site 717785000269 H-loop/switch region; other site 717785000270 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785000271 catalytic residues [active] 717785000272 catalytic nucleophile [active] 717785000273 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785000274 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785000275 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785000276 Synaptic Site I dimer interface [polypeptide binding]; other site 717785000277 DNA binding site [nucleotide binding] 717785000278 Recombinase; Region: Recombinase; pfam07508 717785000279 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785000280 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785000281 Protein of unknown function, DUF417; Region: DUF417; cl01162 717785000282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785000283 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 717785000284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000286 dimerization interface [polypeptide binding]; other site 717785000287 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 717785000288 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 717785000289 putative NAD(P) binding site [chemical binding]; other site 717785000290 dimer interface [polypeptide binding]; other site 717785000291 Cupin domain; Region: Cupin_2; cl09118 717785000292 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785000293 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 717785000294 Major royal jelly protein; Region: MRJP; pfam03022 717785000295 Major royal jelly protein; Region: MRJP; pfam03022 717785000296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785000298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785000300 DNA binding residues [nucleotide binding] 717785000301 dimerization interface [polypeptide binding]; other site 717785000302 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785000303 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000304 active site 717785000305 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785000306 dimer interface [polypeptide binding]; other site 717785000307 non-prolyl cis peptide bond; other site 717785000308 insertion regions; other site 717785000309 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 717785000310 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 717785000311 Flavin binding site [chemical binding]; other site 717785000312 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785000313 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785000314 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785000315 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785000316 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000317 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785000318 active site 717785000319 dimer interface [polypeptide binding]; other site 717785000320 non-prolyl cis peptide bond; other site 717785000321 insertion regions; other site 717785000322 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 717785000323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785000324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000325 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785000326 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785000327 catalytic residues [active] 717785000328 catalytic nucleophile [active] 717785000329 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785000330 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785000331 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785000332 Synaptic Site I dimer interface [polypeptide binding]; other site 717785000333 DNA binding site [nucleotide binding] 717785000334 Recombinase; Region: Recombinase; pfam07508 717785000335 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785000336 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785000337 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785000338 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785000339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785000340 catalytic residue [active] 717785000341 serine O-acetyltransferase; Region: cysE; TIGR01172 717785000342 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 717785000343 trimer interface [polypeptide binding]; other site 717785000344 active site 717785000345 substrate binding site [chemical binding]; other site 717785000346 CoA binding site [chemical binding]; other site 717785000347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000348 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000351 dimerization interface [polypeptide binding]; other site 717785000352 hypothetical protein; Provisional; Region: PRK09897 717785000353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785000354 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 717785000355 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000356 Walker A/P-loop; other site 717785000357 ATP binding site [chemical binding]; other site 717785000358 Q-loop/lid; other site 717785000359 ABC transporter signature motif; other site 717785000360 Walker B; other site 717785000361 D-loop; other site 717785000362 H-loop/switch region; other site 717785000363 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785000365 dimer interface [polypeptide binding]; other site 717785000366 conserved gate region; other site 717785000367 putative PBP binding loops; other site 717785000368 ABC-ATPase subunit interface; other site 717785000369 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000370 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785000371 active site 717785000372 dimer interface [polypeptide binding]; other site 717785000373 non-prolyl cis peptide bond; other site 717785000374 insertion regions; other site 717785000375 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785000376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785000377 substrate binding pocket [chemical binding]; other site 717785000378 membrane-bound complex binding site; other site 717785000379 hinge residues; other site 717785000380 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785000381 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785000382 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785000383 inhibitor site; inhibition site 717785000384 active site 717785000385 dimer interface [polypeptide binding]; other site 717785000386 catalytic residue [active] 717785000387 benzoate transport; Region: 2A0115; TIGR00895 717785000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000389 putative substrate translocation pore; other site 717785000390 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785000391 active site 717785000392 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785000393 dimer interface [polypeptide binding]; other site 717785000394 non-prolyl cis peptide bond; other site 717785000395 insertion regions; other site 717785000396 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785000397 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785000398 active site 717785000399 non-prolyl cis peptide bond; other site 717785000400 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785000401 substrate binding site [chemical binding]; other site 717785000402 oxyanion hole (OAH) forming residues; other site 717785000403 trimer interface [polypeptide binding]; other site 717785000404 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785000405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000406 oxidoreductase; Provisional; Region: PRK06196 717785000407 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 717785000408 putative NAD(P) binding site [chemical binding]; other site 717785000409 active site 717785000410 Cupin domain; Region: Cupin_2; cl09118 717785000411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785000412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000413 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785000414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785000415 active site 717785000416 catalytic tetrad [active] 717785000417 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 717785000418 TM-ABC transporter signature motif; other site 717785000419 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 717785000420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000421 Walker A/P-loop; other site 717785000422 ATP binding site [chemical binding]; other site 717785000423 Q-loop/lid; other site 717785000424 ABC transporter signature motif; other site 717785000425 Walker B; other site 717785000426 D-loop; other site 717785000427 H-loop/switch region; other site 717785000428 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 717785000429 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 717785000430 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 717785000431 ligand binding site [chemical binding]; other site 717785000432 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 717785000433 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785000434 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 717785000435 active site 717785000436 metal binding site [ion binding]; metal-binding site 717785000437 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 717785000438 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785000439 metal ion-dependent adhesion site (MIDAS); other site 717785000440 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 717785000441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000442 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785000443 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785000444 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785000445 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 717785000446 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000447 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 717785000448 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000449 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785000450 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 717785000451 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 717785000452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000454 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 717785000455 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785000456 homotrimer interaction site [polypeptide binding]; other site 717785000457 putative active site [active] 717785000458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000459 Transcriptional regulator [Transcription]; Region: IclR; COG1414 717785000460 Bacterial transcriptional regulator; Region: IclR; pfam01614 717785000461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000462 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 717785000463 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785000464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000465 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 717785000466 Walker A/P-loop; other site 717785000467 ATP binding site [chemical binding]; other site 717785000468 Q-loop/lid; other site 717785000469 ABC transporter signature motif; other site 717785000470 Walker B; other site 717785000471 D-loop; other site 717785000472 H-loop/switch region; other site 717785000473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785000474 dimer interface [polypeptide binding]; other site 717785000475 conserved gate region; other site 717785000476 ABC-ATPase subunit interface; other site 717785000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785000478 dimer interface [polypeptide binding]; other site 717785000479 conserved gate region; other site 717785000480 putative PBP binding loops; other site 717785000481 ABC-ATPase subunit interface; other site 717785000482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 717785000484 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785000485 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785000486 NAD(P) binding site [chemical binding]; other site 717785000487 catalytic residues [active] 717785000488 choline dehydrogenase; Validated; Region: PRK02106 717785000489 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785000490 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000491 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000492 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000493 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000494 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785000495 Cytochrome c; Region: Cytochrom_C; cl11414 717785000496 Cytochrome c; Region: Cytochrom_C; cl11414 717785000497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000498 FAD binding domain; Region: FAD_binding_3; pfam01494 717785000499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000500 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 717785000501 Isochorismatase family; Region: Isochorismatase; pfam00857 717785000502 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-...; Region: CSHase; cd01015 717785000503 substrate binding site [chemical binding]; other site 717785000504 catalytic triad [active] 717785000505 domain interfaces; other site 717785000506 conserved cis-peptide bond; other site 717785000507 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 717785000508 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785000509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785000511 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 717785000512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785000513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000515 dimerization interface [polypeptide binding]; other site 717785000516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785000517 classical (c) SDRs; Region: SDR_c; cd05233 717785000518 NAD(P) binding site [chemical binding]; other site 717785000519 active site 717785000520 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 717785000521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785000522 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 717785000523 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785000524 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 717785000525 DEAD-like helicases superfamily; Region: DEXDc; smart00487 717785000526 ATP binding site [chemical binding]; other site 717785000527 Mg++ binding site [ion binding]; other site 717785000528 motif III; other site 717785000529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785000530 nucleotide binding region [chemical binding]; other site 717785000531 ATP-binding site [chemical binding]; other site 717785000532 DbpA RNA binding domain; Region: DbpA; pfam03880 717785000533 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 717785000534 DNA binding residues [nucleotide binding] 717785000535 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 717785000536 dimer interface [polypeptide binding]; other site 717785000537 putative metal binding site [ion binding]; other site 717785000538 Cation efflux family; Region: Cation_efflux; cl00316 717785000539 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480 717785000540 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 717785000541 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 717785000542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000543 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785000544 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000545 ligand binding site [chemical binding]; other site 717785000546 flexible hinge region; other site 717785000547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000548 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 717785000549 heme-binding site [chemical binding]; other site 717785000550 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 717785000551 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 717785000552 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785000553 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785000554 inhibitor site; inhibition site 717785000555 active site 717785000556 dimer interface [polypeptide binding]; other site 717785000557 catalytic residue [active] 717785000558 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 717785000559 intersubunit interface [polypeptide binding]; other site 717785000560 active site 717785000561 Zn2+ binding site [ion binding]; other site 717785000562 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785000563 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785000564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000565 DNA-binding site [nucleotide binding]; DNA binding site 717785000566 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785000567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785000569 homodimer interface [polypeptide binding]; other site 717785000570 catalytic residue [active] 717785000571 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 717785000572 Active site [active] 717785000573 Protein kinase; unclassified specificity; Region: STYKc; smart00221 717785000574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785000575 active site 717785000576 substrate binding site [chemical binding]; other site 717785000577 ATP binding site [chemical binding]; other site 717785000578 activation loop (A-loop); other site 717785000579 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785000580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000581 DNA-binding site [nucleotide binding]; DNA binding site 717785000582 FCD domain; Region: FCD; cl11656 717785000583 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 717785000584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000585 domain; Region: Succ_DH_flav_C; pfam02910 717785000586 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 717785000587 Ferredoxin [Energy production and conversion]; Region: COG1146 717785000588 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 717785000589 Creatinine amidohydrolase; Region: Creatininase; cl00618 717785000590 ferredoxin-NADP+ reductase; Region: PLN02852 717785000591 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785000592 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785000593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785000594 catalytic residue [active] 717785000595 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 717785000596 putative hydrophobic ligand binding site [chemical binding]; other site 717785000597 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785000598 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 717785000599 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785000600 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785000601 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 717785000602 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785000603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 717785000604 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785000605 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785000606 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785000608 dimer interface [polypeptide binding]; other site 717785000609 conserved gate region; other site 717785000610 putative PBP binding loops; other site 717785000611 ABC-ATPase subunit interface; other site 717785000612 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785000613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000614 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785000615 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000616 Walker A/P-loop; other site 717785000617 ATP binding site [chemical binding]; other site 717785000618 Q-loop/lid; other site 717785000619 ABC transporter signature motif; other site 717785000620 Walker B; other site 717785000621 D-loop; other site 717785000622 H-loop/switch region; other site 717785000623 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 717785000624 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785000625 NAD binding site [chemical binding]; other site 717785000626 catalytic residues [active] 717785000627 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785000628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785000629 DNA-binding site [nucleotide binding]; DNA binding site 717785000630 FCD domain; Region: FCD; cl11656 717785000631 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 717785000632 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 717785000633 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 717785000634 Flavin Reductases; Region: FlaRed; cl00801 717785000635 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785000636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000637 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 717785000638 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785000639 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785000640 Walker A/P-loop; other site 717785000641 ATP binding site [chemical binding]; other site 717785000642 Q-loop/lid; other site 717785000643 ABC transporter signature motif; other site 717785000644 Walker B; other site 717785000645 D-loop; other site 717785000646 H-loop/switch region; other site 717785000647 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785000648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785000649 dimer interface [polypeptide binding]; other site 717785000650 conserved gate region; other site 717785000651 putative PBP binding loops; other site 717785000652 ABC-ATPase subunit interface; other site 717785000653 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 717785000654 Flavoprotein; Region: Flavoprotein; cl08021 717785000655 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 717785000656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 717785000658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 717785000659 active site 717785000660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 717785000661 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 717785000662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000663 D-galactonate transporter; Region: 2A0114; TIGR00893 717785000664 putative substrate translocation pore; other site 717785000665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 717785000666 active site 717785000667 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785000668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785000669 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 717785000670 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 717785000671 active site 717785000672 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 717785000673 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785000674 N-terminal plug; other site 717785000675 ligand-binding site [chemical binding]; other site 717785000676 alpha/beta hydrolase fold protein (pseudogene);Evidence 7 : Gene remnant 717785000677 Evidence 7 : Gene remnant 717785000678 Evidence 7 : Gene remnant 717785000679 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717785000680 Cation efflux family; Region: Cation_efflux; cl00316 717785000681 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 717785000682 Found in ATP-dependent protease La (LON); Region: LON; cl01056 717785000683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785000684 Walker A motif; other site 717785000685 ATP binding site [chemical binding]; other site 717785000686 Walker B motif; other site 717785000687 arginine finger; other site 717785000688 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717785000689 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 717785000690 putative dimer interface [polypeptide binding]; other site 717785000691 CreA protein; Region: CreA; cl01154 717785000692 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 717785000693 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 717785000694 putative molybdopterin cofactor binding site [chemical binding]; other site 717785000695 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 717785000696 putative molybdopterin cofactor binding site; other site 717785000697 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 717785000698 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 717785000699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785000700 metal binding site [ion binding]; metal-binding site 717785000701 active site 717785000702 I-site; other site 717785000703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785000705 S-adenosylmethionine binding site [chemical binding]; other site 717785000706 hypothetical protein; Provisional; Region: PRK08317 717785000707 CoA-transferase family III; Region: CoA_transf_3; cl00778 717785000708 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 717785000709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785000710 FAD binding site [chemical binding]; other site 717785000711 substrate binding pocket [chemical binding]; other site 717785000712 catalytic base [active] 717785000713 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 717785000714 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 717785000715 catalytic triad [active] 717785000716 MarC family integral membrane protein; Region: MarC; cl00919 717785000717 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 717785000718 nudix motif; other site 717785000719 salicylate hydroxylase; Provisional; Region: PRK08163 717785000720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000721 Zinc-finger domain; Region: zf-CHCC; cl01821 717785000722 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 717785000723 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000724 nucleophilic elbow; other site 717785000725 catalytic triad; other site 717785000726 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785000727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785000728 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 717785000729 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 717785000730 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 717785000731 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 717785000732 putative metal binding site [ion binding]; other site 717785000733 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785000734 HSP70 interaction site [polypeptide binding]; other site 717785000735 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 717785000736 amidase catalytic site [active] 717785000737 Zn binding residues [ion binding]; other site 717785000738 substrate binding site [chemical binding]; other site 717785000739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785000740 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 717785000741 Sulfatase; Region: Sulfatase; cl10460 717785000742 secreted effector protein PipB2; Provisional; Region: PRK15196 717785000743 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000744 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000745 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785000746 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 717785000747 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 717785000748 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 717785000749 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785000750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785000751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000752 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 717785000753 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 717785000754 cell division protein MraZ; Reviewed; Region: PRK00326 717785000755 MraZ protein; Region: MraZ; pfam02381 717785000756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785000757 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 717785000758 Septum formation initiator; Region: DivIC; cl11433 717785000759 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 717785000760 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 717785000761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785000762 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 717785000763 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000764 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000765 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 717785000767 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000769 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 717785000770 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 717785000771 Mg++ binding site [ion binding]; other site 717785000772 putative catalytic motif [active] 717785000773 putative substrate binding site [chemical binding]; other site 717785000774 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 717785000775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000777 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 717785000778 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 717785000779 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 717785000780 active site 717785000781 homodimer interface [polypeptide binding]; other site 717785000782 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 717785000783 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 717785000784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 717785000785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 717785000786 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 717785000787 FAD binding domain; Region: FAD_binding_4; pfam01565 717785000788 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 717785000789 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 717785000790 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 717785000791 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785000792 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 717785000793 Cell division protein FtsQ; Region: FtsQ; pfam03799 717785000794 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 717785000795 Cell division protein FtsA; Region: FtsA; cl11496 717785000796 Cell division protein FtsA; Region: FtsA; cl11496 717785000797 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 717785000798 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 717785000799 nucleotide binding site [chemical binding]; other site 717785000800 SulA interaction site; other site 717785000801 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 717785000802 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 717785000803 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 717785000804 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 717785000805 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 717785000806 nucleotide binding pocket [chemical binding]; other site 717785000807 K-X-D-G motif; other site 717785000808 catalytic site [active] 717785000809 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 717785000810 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 717785000811 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 717785000812 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 717785000813 Dimer interface [polypeptide binding]; other site 717785000814 BRCT sequence motif; other site 717785000815 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 717785000816 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 717785000817 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 717785000818 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 717785000819 active site 717785000820 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 717785000821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785000822 S-adenosylmethionine binding site [chemical binding]; other site 717785000823 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 717785000824 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785000825 HSP70 interaction site [polypeptide binding]; other site 717785000826 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 717785000827 UvrD/REP helicase; Region: UvrD-helicase; cl14126 717785000828 AsmA family; Region: AsmA; pfam05170 717785000829 GTP-binding protein LepA; Provisional; Region: PRK05433 717785000830 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 717785000831 G1 box; other site 717785000832 putative GEF interaction site [polypeptide binding]; other site 717785000833 GTP/Mg2+ binding site [chemical binding]; other site 717785000834 Switch I region; other site 717785000835 G2 box; other site 717785000836 G3 box; other site 717785000837 Switch II region; other site 717785000838 G4 box; other site 717785000839 G5 box; other site 717785000840 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 717785000841 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 717785000842 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 717785000843 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 717785000844 diiron binding motif [ion binding]; other site 717785000845 Uncharacterized conserved protein [Function unknown]; Region: COG1633 717785000846 CCC1-related protein family; Region: CCC1_like_1; cd02437 717785000847 lytic murein transglycosylase; Region: MltB_2; TIGR02283 717785000848 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 717785000849 N-acetyl-D-glucosamine binding site [chemical binding]; other site 717785000850 catalytic residue [active] 717785000851 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785000852 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 717785000853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785000855 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 717785000856 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 717785000857 putative tRNA-binding site [nucleotide binding]; other site 717785000858 B3/4 domain; Region: B3_4; cl11458 717785000859 tRNA synthetase B5 domain; Region: B5; cl08394 717785000860 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 717785000861 dimer interface [polypeptide binding]; other site 717785000862 motif 1; other site 717785000863 motif 3; other site 717785000864 motif 2; other site 717785000865 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 717785000866 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 717785000867 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 717785000868 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 717785000869 dimer interface [polypeptide binding]; other site 717785000870 motif 1; other site 717785000871 active site 717785000872 motif 2; other site 717785000873 motif 3; other site 717785000874 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 717785000875 23S rRNA binding site [nucleotide binding]; other site 717785000876 L21 binding site [polypeptide binding]; other site 717785000877 L13 binding site [polypeptide binding]; other site 717785000878 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 717785000879 GtrA-like protein; Region: GtrA; cl00971 717785000880 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785000881 ligand binding site [chemical binding]; other site 717785000882 flexible hinge region; other site 717785000883 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 717785000884 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 717785000885 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 717785000886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785000887 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 717785000888 putative ADP-binding pocket [chemical binding]; other site 717785000889 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785000890 putative metal binding site [ion binding]; other site 717785000891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785000892 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 717785000893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785000894 putative NAD(P) binding site [chemical binding]; other site 717785000895 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 717785000896 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 717785000897 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785000898 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 717785000899 C-terminal domain interface [polypeptide binding]; other site 717785000900 GSH binding site (G-site) [chemical binding]; other site 717785000901 dimer interface [polypeptide binding]; other site 717785000902 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 717785000903 N-terminal domain interface [polypeptide binding]; other site 717785000904 dimer interface [polypeptide binding]; other site 717785000905 substrate binding pocket (H-site) [chemical binding]; other site 717785000906 Bacitracin resistance protein BacA; Region: BacA; cl00858 717785000907 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 717785000908 active site 717785000909 phosphorylation site [posttranslational modification] 717785000910 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 717785000911 30S subunit binding site; other site 717785000912 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 717785000913 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 717785000914 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 717785000915 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 717785000916 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 717785000917 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 717785000918 Walker A/P-loop; other site 717785000919 ATP binding site [chemical binding]; other site 717785000920 Q-loop/lid; other site 717785000921 ABC transporter signature motif; other site 717785000922 Walker B; other site 717785000923 D-loop; other site 717785000924 H-loop/switch region; other site 717785000925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 717785000926 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 717785000927 OstA-like protein; Region: OstA; cl00844 717785000928 OstA-like protein; Region: OstA; cl00844 717785000929 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 717785000930 putative active site [active] 717785000931 catalytic site [active] 717785000932 putative substrate binding site [chemical binding]; other site 717785000933 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000935 putative substrate translocation pore; other site 717785000936 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785000937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785000938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785000939 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785000940 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785000941 E3 interaction surface; other site 717785000942 lipoyl attachment site [posttranslational modification]; other site 717785000943 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000945 putative substrate translocation pore; other site 717785000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000947 benzoate transport; Region: 2A0115; TIGR00895 717785000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000949 putative substrate translocation pore; other site 717785000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785000951 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785000952 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785000953 active site 717785000954 catalytic tetrad [active] 717785000955 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 717785000956 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 717785000957 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 717785000958 Isochorismatase family; Region: Isochorismatase; pfam00857 717785000959 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785000960 catalytic triad [active] 717785000961 conserved cis-peptide bond; other site 717785000962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785000963 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 717785000964 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 717785000965 cobalamin binding residues [chemical binding]; other site 717785000966 putative BtuC binding residues; other site 717785000967 dimer interface [polypeptide binding]; other site 717785000968 MOSC domain; Region: MOSC; pfam03473 717785000969 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 717785000970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785000971 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785000972 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 717785000973 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 717785000974 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 717785000975 Walker A/P-loop; other site 717785000976 ATP binding site [chemical binding]; other site 717785000977 Q-loop/lid; other site 717785000978 ABC transporter signature motif; other site 717785000979 Walker B; other site 717785000980 D-loop; other site 717785000981 H-loop/switch region; other site 717785000982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000983 Walker A/P-loop; other site 717785000984 ATP binding site [chemical binding]; other site 717785000985 Q-loop/lid; other site 717785000986 ABC transporter signature motif; other site 717785000987 Walker B; other site 717785000988 D-loop; other site 717785000989 H-loop/switch region; other site 717785000990 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717785000991 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785000992 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785000993 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785000994 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785000995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785000996 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785000997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785000998 Walker A/P-loop; other site 717785000999 ATP binding site [chemical binding]; other site 717785001000 Q-loop/lid; other site 717785001001 ABC transporter signature motif; other site 717785001002 Walker B; other site 717785001003 D-loop; other site 717785001004 H-loop/switch region; other site 717785001005 TOBE domain; Region: TOBE_2; cl01440 717785001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001007 dimer interface [polypeptide binding]; other site 717785001008 conserved gate region; other site 717785001009 putative PBP binding loops; other site 717785001010 ABC-ATPase subunit interface; other site 717785001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001012 dimer interface [polypeptide binding]; other site 717785001013 conserved gate region; other site 717785001014 putative PBP binding loops; other site 717785001015 ABC-ATPase subunit interface; other site 717785001016 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785001017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785001018 SurA N-terminal domain; Region: SurA_N; pfam09312 717785001019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785001020 tyramine oxidase; Provisional; Region: tynA; PRK11504 717785001021 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 717785001022 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 717785001023 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 717785001024 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 717785001025 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 717785001026 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 717785001027 dimer interface [polypeptide binding]; other site 717785001028 PYR/PP interface [polypeptide binding]; other site 717785001029 TPP binding site [chemical binding]; other site 717785001030 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785001031 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 717785001032 TPP-binding site [chemical binding]; other site 717785001033 dimer interface [polypeptide binding]; other site 717785001034 FOG: CBS domain [General function prediction only]; Region: COG0517 717785001035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 717785001036 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 717785001037 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 717785001038 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 717785001039 NAD(P) binding site [chemical binding]; other site 717785001040 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 717785001041 putative dimer interface [polypeptide binding]; other site 717785001042 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 717785001043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001044 YCII-related domain; Region: YCII; cl00999 717785001045 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 717785001046 putative hydrophobic ligand binding site [chemical binding]; other site 717785001047 transcriptional regulator; Provisional; Region: PRK10632 717785001048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001049 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 717785001050 putative effector binding pocket; other site 717785001051 putative dimerization interface [polypeptide binding]; other site 717785001052 short chain dehydrogenase; Provisional; Region: PRK12744 717785001053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785001054 NAD(P) binding site [chemical binding]; other site 717785001055 active site 717785001056 oxidoreductase; Provisional; Region: PRK06196 717785001057 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 717785001058 putative NAD(P) binding site [chemical binding]; other site 717785001059 active site 717785001060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001062 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 717785001063 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 717785001064 putative active site [active] 717785001065 catalytic triad [active] 717785001066 putative dimer interface [polypeptide binding]; other site 717785001067 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785001068 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785001069 active site 717785001070 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785001071 non-prolyl cis peptide bond; other site 717785001072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785001073 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785001074 Walker A/P-loop; other site 717785001075 ATP binding site [chemical binding]; other site 717785001076 Q-loop/lid; other site 717785001077 ABC transporter signature motif; other site 717785001078 Walker B; other site 717785001079 D-loop; other site 717785001080 H-loop/switch region; other site 717785001081 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785001082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 717785001083 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785001084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785001085 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785001086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785001087 HupE / UreJ protein; Region: HupE_UreJ; cl01011 717785001088 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 717785001089 dimerization interface [polypeptide binding]; other site 717785001090 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 717785001091 ATP binding site [chemical binding]; other site 717785001092 Hydrogenase formation hypA family; Region: HypD; cl12072 717785001093 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 717785001094 HupF/HypC family; Region: HupF_HypC; cl00394 717785001095 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 717785001096 Acylphosphatase; Region: Acylphosphatase; cl00551 717785001097 HypF finger; Region: zf-HYPF; pfam07503 717785001098 HypF finger; Region: zf-HYPF; pfam07503 717785001099 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 717785001100 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785001101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001102 active site 717785001103 phosphorylation site [posttranslational modification] 717785001104 intermolecular recognition site; other site 717785001105 dimerization interface [polypeptide binding]; other site 717785001106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785001107 Walker A motif; other site 717785001108 ATP binding site [chemical binding]; other site 717785001109 Walker B motif; other site 717785001110 arginine finger; other site 717785001111 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785001112 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 717785001113 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785001114 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 717785001115 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 717785001116 Rubredoxin; Region: Rubredoxin; pfam00301 717785001117 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 717785001118 iron binding site [ion binding]; other site 717785001119 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 717785001120 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 717785001121 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as...; Region: HyaE; cd02965 717785001122 HupF/HypC family; Region: HupF_HypC; cl00394 717785001123 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 717785001124 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 717785001125 putative substrate-binding site; other site 717785001126 nickel binding site [ion binding]; other site 717785001127 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785001128 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 717785001129 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 717785001130 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 717785001131 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 717785001132 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 717785001133 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 717785001134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785001135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785001136 putative active site [active] 717785001137 heme pocket [chemical binding]; other site 717785001138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785001139 dimer interface [polypeptide binding]; other site 717785001140 phosphorylation site [posttranslational modification] 717785001141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001142 ATP binding site [chemical binding]; other site 717785001143 Mg2+ binding site [ion binding]; other site 717785001144 G-X-G motif; other site 717785001145 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 717785001146 active site 717785001147 DNA binding site [nucleotide binding] 717785001148 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785001149 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785001150 active site 717785001151 metal binding site [ion binding]; metal-binding site 717785001152 Cytochrome c; Region: Cytochrom_C; cl11414 717785001153 RNA polymerase sigma factor; Provisional; Region: PRK11924 717785001154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785001156 DNA binding residues [nucleotide binding] 717785001157 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 717785001158 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 717785001159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785001160 DNA-binding site [nucleotide binding]; DNA binding site 717785001161 FCD domain; Region: FCD; cl11656 717785001162 L-lactate permease; Region: Lactate_perm; cl00701 717785001163 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785001164 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785001165 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785001166 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 717785001167 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785001168 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785001169 Coenzyme A transferase; Region: CoA_trans; cl00773 717785001170 Coenzyme A transferase; Region: CoA_trans; cl00773 717785001171 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 717785001172 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 717785001173 tetramer interface [polypeptide binding]; other site 717785001174 catalytic Zn binding site [ion binding]; other site 717785001175 NADP binding site [chemical binding]; other site 717785001176 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; cl01902 717785001177 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 717785001178 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 717785001179 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 717785001180 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 717785001181 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 717785001182 GAF domain; Region: GAF; cl00853 717785001183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785001184 Walker A motif; other site 717785001185 ATP binding site [chemical binding]; other site 717785001186 Walker B motif; other site 717785001187 arginine finger; other site 717785001188 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785001189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785001190 Histidine kinase; Region: HisKA_3; pfam07730 717785001191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001192 ATP binding site [chemical binding]; other site 717785001193 Mg2+ binding site [ion binding]; other site 717785001194 G-X-G motif; other site 717785001195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001197 active site 717785001198 phosphorylation site [posttranslational modification] 717785001199 intermolecular recognition site; other site 717785001200 dimerization interface [polypeptide binding]; other site 717785001201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 717785001202 DNA binding residues [nucleotide binding] 717785001203 dimerization interface [polypeptide binding]; other site 717785001204 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 717785001205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001207 active site 717785001208 phosphorylation site [posttranslational modification] 717785001209 intermolecular recognition site; other site 717785001210 dimerization interface [polypeptide binding]; other site 717785001211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785001212 DNA binding residues [nucleotide binding] 717785001213 dimerization interface [polypeptide binding]; other site 717785001214 Histidine kinase; Region: HisKA_3; pfam07730 717785001215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001216 ATP binding site [chemical binding]; other site 717785001217 Mg2+ binding site [ion binding]; other site 717785001218 G-X-G motif; other site 717785001219 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785001220 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 717785001221 Trp docking motif; other site 717785001222 'Velcro' closure; other site 717785001223 active site 717785001224 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717785001225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785001226 substrate binding pocket [chemical binding]; other site 717785001227 membrane-bound complex binding site; other site 717785001228 hinge residues; other site 717785001229 Cytochrome c; Region: Cytochrom_C; cl11414 717785001230 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 717785001231 MoxR-like ATPases [General function prediction only]; Region: COG0714 717785001232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785001233 Walker A motif; other site 717785001234 ATP binding site [chemical binding]; other site 717785001235 Walker B motif; other site 717785001236 arginine finger; other site 717785001237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785001238 metal ion-dependent adhesion site (MIDAS); other site 717785001239 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 717785001240 metal ion-dependent adhesion site (MIDAS); other site 717785001241 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785001242 putative hydrophobic ligand binding site [chemical binding]; other site 717785001243 protein interface [polypeptide binding]; other site 717785001244 gate; other site 717785001245 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 717785001246 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001247 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001248 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001249 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785001250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785001251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001252 active site 717785001253 phosphorylation site [posttranslational modification] 717785001254 intermolecular recognition site; other site 717785001255 dimerization interface [polypeptide binding]; other site 717785001256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785001257 DNA binding residues [nucleotide binding] 717785001258 dimerization interface [polypeptide binding]; other site 717785001259 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 717785001260 Ca2+ binding site [ion binding]; other site 717785001261 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 717785001262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001263 active site 717785001264 phosphorylation site [posttranslational modification] 717785001265 intermolecular recognition site; other site 717785001266 dimerization interface [polypeptide binding]; other site 717785001267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785001268 DNA binding site [nucleotide binding] 717785001269 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 717785001270 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785001271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785001272 dimer interface [polypeptide binding]; other site 717785001273 phosphorylation site [posttranslational modification] 717785001274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001275 ATP binding site [chemical binding]; other site 717785001276 Mg2+ binding site [ion binding]; other site 717785001277 G-X-G motif; other site 717785001278 Thermostable hemolysin; Region: T_hemolysin; pfam12261 717785001279 AMP-binding enzyme; Region: AMP-binding; pfam00501 717785001280 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785001281 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 717785001282 heme binding pocket [chemical binding]; other site 717785001283 heme ligand [chemical binding]; other site 717785001284 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785001285 classical (c) SDRs; Region: SDR_c; cd05233 717785001286 NAD(P) binding site [chemical binding]; other site 717785001287 active site 717785001288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785001289 TPR motif; other site 717785001290 binding surface 717785001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785001292 S-adenosylmethionine binding site [chemical binding]; other site 717785001293 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785001294 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785001295 catalytic residues [active] 717785001296 catalytic nucleophile [active] 717785001297 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785001298 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785001299 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785001300 Synaptic Site I dimer interface [polypeptide binding]; other site 717785001301 DNA binding site [nucleotide binding] 717785001302 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785001303 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 717785001304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785001305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785001306 DNA binding site [nucleotide binding] 717785001307 Int/Topo IB signature motif; other site 717785001308 active site 717785001309 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 717785001310 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717785001311 putative NAD(P) binding site [chemical binding]; other site 717785001312 active site 717785001313 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 717785001314 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 717785001315 putative dimer interface [polypeptide binding]; other site 717785001316 ABC transporter ATPase component; Reviewed; Region: PRK11147 717785001317 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785001318 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785001319 Protein of unknown function (DUF466); Region: DUF466; cl01082 717785001320 Carbon starvation protein CstA; Region: CstA; cl00856 717785001321 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 717785001322 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 717785001323 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 717785001324 hinge; other site 717785001325 active site 717785001326 cytidylate kinase; Provisional; Region: cmk; PRK00023 717785001327 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 717785001328 CMP-binding site; other site 717785001329 The sites determining sugar specificity; other site 717785001330 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 717785001331 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 717785001332 dimer interface [polypeptide binding]; other site 717785001333 TPP-binding site [chemical binding]; other site 717785001334 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 717785001335 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 717785001336 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785001337 E3 interaction surface; other site 717785001338 lipoyl attachment site [posttranslational modification]; other site 717785001339 e3 binding domain; Region: E3_binding; pfam02817 717785001340 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 717785001341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785001342 E3 interaction surface; other site 717785001343 lipoyl attachment site [posttranslational modification]; other site 717785001344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785001345 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 717785001346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785001347 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785001348 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 717785001349 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 717785001350 RNA binding site [nucleotide binding]; other site 717785001351 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 717785001352 RNA binding site [nucleotide binding]; other site 717785001353 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 717785001354 RNA binding site [nucleotide binding]; other site 717785001355 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 717785001356 RNA binding site [nucleotide binding]; other site 717785001357 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 717785001358 RNA binding site [nucleotide binding]; other site 717785001359 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 717785001360 RNA binding site [nucleotide binding]; other site 717785001361 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 717785001362 tandem repeat interface [polypeptide binding]; other site 717785001363 oligomer interface [polypeptide binding]; other site 717785001364 active site residues [active] 717785001365 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 717785001366 IHF dimer interface [polypeptide binding]; other site 717785001367 IHF - DNA interface [nucleotide binding]; other site 717785001368 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 717785001369 active site 717785001370 tryptophan synthase, beta chain; Region: PLN02618 717785001371 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 717785001372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785001373 catalytic residue [active] 717785001374 tryptophan synthase; Region: PLN02591 717785001375 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 717785001376 substrate binding site [chemical binding]; other site 717785001377 active site 717785001378 catalytic residues [active] 717785001379 heterodimer interface [polypeptide binding]; other site 717785001380 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 717785001381 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 717785001382 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 717785001383 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 717785001384 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785001385 NAD(P) binding site [chemical binding]; other site 717785001386 catalytic residues [active] 717785001387 Protein of unknown function (DUF779); Region: DUF779; cl01432 717785001388 Protein of unknown function (DUF779); Region: DUF779; cl01432 717785001389 Isochorismatase family; Region: Isochorismatase; pfam00857 717785001390 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 717785001391 catalytic triad [active] 717785001392 conserved cis-peptide bond; other site 717785001393 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 717785001394 catalytic residues [active] 717785001395 UvrD/REP helicase; Region: UvrD-helicase; cl14126 717785001396 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 717785001397 UvrD/REP helicase; Region: UvrD-helicase; cl14126 717785001398 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 717785001399 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 717785001400 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 717785001401 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 717785001402 Substrate binding site [chemical binding]; other site 717785001403 metal binding site [ion binding]; metal-binding site 717785001404 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 717785001405 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785001406 Phosphotransferase enzyme family; Region: APH; pfam01636 717785001407 hypothetical protein; Provisional; Region: PRK13560 717785001408 PAS fold; Region: PAS_7; pfam12860 717785001409 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 717785001410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785001411 dimer interface [polypeptide binding]; other site 717785001412 phosphorylation site [posttranslational modification] 717785001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001414 ATP binding site [chemical binding]; other site 717785001415 Mg2+ binding site [ion binding]; other site 717785001416 G-X-G motif; other site 717785001417 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 717785001418 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 717785001419 oligomerization interface [polypeptide binding]; other site 717785001420 active site 717785001421 NAD+ binding site [chemical binding]; other site 717785001422 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001423 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785001424 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 717785001425 dimerization domain swap beta strand [polypeptide binding]; other site 717785001426 regulatory protein interface [polypeptide binding]; other site 717785001427 active site 717785001428 regulatory phosphorylation site [posttranslational modification]; other site 717785001429 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 717785001430 active pocket/dimerization site; other site 717785001431 active site 717785001432 phosphorylation site [posttranslational modification] 717785001433 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 717785001434 Hpr binding site; other site 717785001435 active site 717785001436 homohexamer subunit interaction site [polypeptide binding]; other site 717785001437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785001438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785001439 dimer interface [polypeptide binding]; other site 717785001440 phosphorylation site [posttranslational modification] 717785001441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001442 ATP binding site [chemical binding]; other site 717785001443 Mg2+ binding site [ion binding]; other site 717785001444 G-X-G motif; other site 717785001445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785001446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001447 active site 717785001448 phosphorylation site [posttranslational modification] 717785001449 intermolecular recognition site; other site 717785001450 dimerization interface [polypeptide binding]; other site 717785001451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785001452 DNA binding site [nucleotide binding] 717785001453 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 717785001454 active site 717785001455 substrate-binding site [chemical binding]; other site 717785001456 metal-binding site [ion binding] 717785001457 ATP binding site [chemical binding]; other site 717785001458 Dienelactone hydrolase family; Region: DLH; pfam01738 717785001459 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785001460 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 717785001461 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 717785001462 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 717785001463 catalytic residues [active] 717785001464 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 717785001465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785001466 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 717785001467 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 717785001468 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785001469 AIR carboxylase; Region: AIRC; cl00310 717785001470 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785001471 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 717785001472 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 717785001473 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 717785001474 metal binding site [ion binding]; metal-binding site 717785001475 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 717785001476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001477 active site 717785001478 phosphorylation site [posttranslational modification] 717785001479 intermolecular recognition site; other site 717785001480 dimerization interface [polypeptide binding]; other site 717785001481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785001482 DNA binding site [nucleotide binding] 717785001483 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 717785001484 PhoU domain; Region: PhoU; pfam01895 717785001485 PhoU domain; Region: PhoU; pfam01895 717785001486 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 717785001487 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 717785001488 Walker A/P-loop; other site 717785001489 ATP binding site [chemical binding]; other site 717785001490 Q-loop/lid; other site 717785001491 ABC transporter signature motif; other site 717785001492 Walker B; other site 717785001493 D-loop; other site 717785001494 H-loop/switch region; other site 717785001495 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 717785001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001497 dimer interface [polypeptide binding]; other site 717785001498 conserved gate region; other site 717785001499 putative PBP binding loops; other site 717785001500 ABC-ATPase subunit interface; other site 717785001501 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 717785001502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001503 dimer interface [polypeptide binding]; other site 717785001504 conserved gate region; other site 717785001505 putative PBP binding loops; other site 717785001506 ABC-ATPase subunit interface; other site 717785001507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785001508 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785001509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785001510 dimer interface [polypeptide binding]; other site 717785001511 phosphorylation site [posttranslational modification] 717785001512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785001513 ATP binding site [chemical binding]; other site 717785001514 Mg2+ binding site [ion binding]; other site 717785001515 G-X-G motif; other site 717785001516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001517 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785001518 Imelysin; Region: Peptidase_M75; cl09159 717785001519 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 717785001520 Multicopper oxidase; Region: Cu-oxidase; cl14658 717785001521 Multicopper oxidase; Region: Cu-oxidase; cl14658 717785001522 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 717785001523 Imelysin; Region: Peptidase_M75; cl09159 717785001524 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 717785001525 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 717785001526 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 717785001527 Ligand binding site [chemical binding]; other site 717785001528 metal binding site [ion binding]; metal-binding site 717785001529 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 717785001530 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 717785001531 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 717785001532 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785001533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785001534 FeS/SAM binding site; other site 717785001535 Cation efflux family; Region: Cation_efflux; cl00316 717785001536 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 717785001537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001538 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001539 TadE-like protein; Region: TadE; pfam07811 717785001540 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 717785001541 TadE-like protein; Region: TadE; pfam07811 717785001542 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 717785001543 Flp/Fap pilin component; Region: Flp_Fap; cl01585 717785001544 Flp/Fap pilin component; Region: Flp_Fap; cl01585 717785001545 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 717785001546 SAF domain; Region: SAF; cl00555 717785001547 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 717785001548 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 717785001549 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 717785001550 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 717785001551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 717785001552 active site 717785001553 phosphorylation site [posttranslational modification] 717785001554 intermolecular recognition site; other site 717785001555 dimerization interface [polypeptide binding]; other site 717785001556 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 717785001557 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 717785001558 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 717785001559 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 717785001560 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 717785001561 ATP binding site [chemical binding]; other site 717785001562 Walker A motif; other site 717785001563 hexamer interface [polypeptide binding]; other site 717785001564 Walker B motif; other site 717785001565 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 717785001566 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 717785001567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785001568 binding surface 717785001569 TPR motif; other site 717785001570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785001571 TPR motif; other site 717785001572 binding surface 717785001573 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 717785001574 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 717785001575 interface (dimer of trimers) [polypeptide binding]; other site 717785001576 Substrate-binding/catalytic site; other site 717785001577 Zn-binding sites [ion binding]; other site 717785001578 NlpC/P60 family; Region: NLPC_P60; cl11438 717785001579 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785001580 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 717785001581 putative C-terminal domain interface [polypeptide binding]; other site 717785001582 putative GSH binding site (G-site) [chemical binding]; other site 717785001583 putative dimer interface [polypeptide binding]; other site 717785001584 GST_C family, unknown subfamily 8; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_8; cd03207 717785001585 putative N-terminal domain interface [polypeptide binding]; other site 717785001586 putative dimer interface [polypeptide binding]; other site 717785001587 putative substrate binding pocket (H-site) [chemical binding]; other site 717785001588 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 717785001589 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 717785001590 Walker A/P-loop; other site 717785001591 ATP binding site [chemical binding]; other site 717785001592 Q-loop/lid; other site 717785001593 ABC transporter signature motif; other site 717785001594 Walker B; other site 717785001595 D-loop; other site 717785001596 H-loop/switch region; other site 717785001597 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 717785001598 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 717785001599 Walker A/P-loop; other site 717785001600 ATP binding site [chemical binding]; other site 717785001601 Q-loop/lid; other site 717785001602 ABC transporter signature motif; other site 717785001603 Walker B; other site 717785001604 D-loop; other site 717785001605 H-loop/switch region; other site 717785001606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 717785001607 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 717785001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001609 dimer interface [polypeptide binding]; other site 717785001610 conserved gate region; other site 717785001611 putative PBP binding loops; other site 717785001612 ABC-ATPase subunit interface; other site 717785001613 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 717785001614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001615 dimer interface [polypeptide binding]; other site 717785001616 conserved gate region; other site 717785001617 putative PBP binding loops; other site 717785001618 ABC-ATPase subunit interface; other site 717785001619 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785001620 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785001621 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785001622 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785001623 Cytochrome c; Region: Cytochrom_C; cl11414 717785001624 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 717785001625 Ligand binding site [chemical binding]; other site 717785001626 oligomer interface [polypeptide binding]; other site 717785001627 prephenate dehydratase; Provisional; Region: PRK11899 717785001628 Prephenate dehydratase; Region: PDT; pfam00800 717785001629 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 717785001630 putative L-Phe binding site [chemical binding]; other site 717785001631 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 717785001632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785001633 Walker A motif; other site 717785001634 ATP binding site [chemical binding]; other site 717785001635 Walker B motif; other site 717785001636 arginine finger; other site 717785001637 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 717785001638 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 717785001639 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 717785001640 recombination protein RecR; Reviewed; Region: recR; PRK00076 717785001641 RecR protein; Region: RecR; pfam02132 717785001642 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 717785001643 putative active site [active] 717785001644 putative metal-binding site [ion binding]; other site 717785001645 tetramer interface [polypeptide binding]; other site 717785001646 putative efflux protein, MATE family; Region: matE; TIGR00797 717785001647 MatE; Region: MatE; pfam01554 717785001648 MatE; Region: MatE; pfam01554 717785001649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785001650 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717785001651 NAD(P) binding site [chemical binding]; other site 717785001652 active site 717785001653 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 717785001654 active site 717785001655 catalytic residues [active] 717785001656 metal binding site [ion binding]; metal-binding site 717785001657 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 717785001658 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 717785001659 putative active site [active] 717785001660 substrate binding site [chemical binding]; other site 717785001661 putative cosubstrate binding site; other site 717785001662 catalytic site [active] 717785001663 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 717785001664 substrate binding site [chemical binding]; other site 717785001665 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 717785001666 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 717785001667 dimerization interface 3.5A [polypeptide binding]; other site 717785001668 active site 717785001669 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 717785001670 homodecamer interface [polypeptide binding]; other site 717785001671 GTP cyclohydrolase I; Provisional; Region: PLN03044 717785001672 active site 717785001673 putative catalytic site residues [active] 717785001674 zinc binding site [ion binding]; other site 717785001675 GTP-CH-I/GFRP interaction surface; other site 717785001676 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785001677 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785001678 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 717785001679 MgtE intracellular N domain; Region: MgtE_N; cl15244 717785001680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 717785001681 Divalent cation transporter; Region: MgtE; cl00786 717785001682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785001683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785001684 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 717785001685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785001686 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785001687 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 717785001688 NAD(P) binding site [chemical binding]; other site 717785001689 catalytic residues [active] 717785001690 short chain dehydrogenase; Provisional; Region: PRK12937 717785001691 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 717785001692 NADP binding site [chemical binding]; other site 717785001693 homodimer interface [polypeptide binding]; other site 717785001694 active site 717785001695 substrate binding site [chemical binding]; other site 717785001696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785001697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 717785001699 putative effector binding pocket; other site 717785001700 putative dimerization interface [polypeptide binding]; other site 717785001701 large tegument protein UL36; Provisional; Region: PHA03247 717785001702 Gram-negative bacterial tonB protein; Region: TonB; cl10048 717785001703 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785001704 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 717785001705 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 717785001706 hinge; other site 717785001707 active site 717785001708 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 717785001709 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 717785001710 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 717785001711 NAD binding site [chemical binding]; other site 717785001712 dimerization interface [polypeptide binding]; other site 717785001713 product binding site; other site 717785001714 substrate binding site [chemical binding]; other site 717785001715 zinc binding site [ion binding]; other site 717785001716 catalytic residues [active] 717785001717 Uncharacterised protein family (UPF0262); Region: UPF0262; cl11489 717785001718 cyclase homology domain; Region: CHD; cd07302 717785001719 nucleotidyl binding site; other site 717785001720 metal binding site [ion binding]; metal-binding site 717785001721 dimer interface [polypeptide binding]; other site 717785001722 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785001723 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785001724 ligand binding site [chemical binding]; other site 717785001725 flexible hinge region; other site 717785001726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001727 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 717785001728 active site 717785001729 dimer interface [polypeptide binding]; other site 717785001730 Domain of unknown function (DUF329); Region: DUF329; cl01144 717785001731 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 717785001732 Moco binding site; other site 717785001733 metal coordination site [ion binding]; other site 717785001734 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 717785001735 Cupin domain; Region: Cupin_2; cl09118 717785001736 Cupin domain; Region: Cupin_2; cl09118 717785001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785001738 binding surface 717785001739 TPR motif; other site 717785001740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785001741 ligand binding site [chemical binding]; other site 717785001742 flexible hinge region; other site 717785001743 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785001744 putative switch regulator; other site 717785001745 non-specific DNA interactions [nucleotide binding]; other site 717785001746 DNA binding site [nucleotide binding] 717785001747 sequence specific DNA binding site [nucleotide binding]; other site 717785001748 putative cAMP binding site [chemical binding]; other site 717785001749 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 717785001750 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 717785001751 active site residue [active] 717785001752 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 717785001753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785001754 Walker A/P-loop; other site 717785001755 ATP binding site [chemical binding]; other site 717785001756 Q-loop/lid; other site 717785001757 ABC transporter signature motif; other site 717785001758 Walker B; other site 717785001759 D-loop; other site 717785001760 H-loop/switch region; other site 717785001761 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785001762 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 717785001763 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 717785001764 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 717785001765 FMN binding site [chemical binding]; other site 717785001766 dimer interface [polypeptide binding]; other site 717785001767 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785001768 CobD/Cbib protein; Region: CobD_Cbib; cl00561 717785001769 cobyric acid synthase; Provisional; Region: PRK00784 717785001770 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785001771 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785001772 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 717785001773 catalytic triad [active] 717785001774 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 717785001775 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 717785001776 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 717785001777 homodimer interface [polypeptide binding]; other site 717785001778 Walker A motif; other site 717785001779 ATP binding site [chemical binding]; other site 717785001780 hydroxycobalamin binding site [chemical binding]; other site 717785001781 Walker B motif; other site 717785001782 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 717785001783 homotrimer interface [polypeptide binding]; other site 717785001784 Walker A motif; other site 717785001785 GTP binding site [chemical binding]; other site 717785001786 Walker B motif; other site 717785001787 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 717785001788 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785001789 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 717785001790 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 717785001791 precorrin-3B synthase; Region: CobG; TIGR02435 717785001792 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785001793 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 717785001794 Precorrin-8X methylmutase; Region: CbiC; pfam02570 717785001795 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785001796 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785001797 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 717785001798 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785001799 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 717785001800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785001801 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 717785001802 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785001803 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 717785001804 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785001805 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 717785001806 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785001807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785001808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785001809 DNA binding residues [nucleotide binding] 717785001810 two-component response regulator; Provisional; Region: PRK09191 717785001811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 717785001812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001813 active site 717785001814 phosphorylation site [posttranslational modification] 717785001815 intermolecular recognition site; other site 717785001816 dimerization interface [polypeptide binding]; other site 717785001817 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785001818 CsbD-like; Region: CsbD; cl01272 717785001819 CHASE3 domain; Region: CHASE3; cl05000 717785001820 Histidine kinase; Region: HisKA_2; cl06527 717785001821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717785001822 response regulator; Provisional; Region: PRK13435 717785001823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001824 active site 717785001825 phosphorylation site [posttranslational modification] 717785001826 intermolecular recognition site; other site 717785001827 dimerization interface [polypeptide binding]; other site 717785001828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785001829 PAS fold; Region: PAS_3; pfam08447 717785001830 putative active site [active] 717785001831 heme pocket [chemical binding]; other site 717785001832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785001833 Histidine kinase; Region: HisKA_2; cl06527 717785001834 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 717785001835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785001836 ATP binding site [chemical binding]; other site 717785001837 Q-loop/lid; other site 717785001838 ABC transporter signature motif; other site 717785001839 Walker B; other site 717785001840 D-loop; other site 717785001841 H-loop/switch region; other site 717785001842 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 717785001843 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785001844 FtsX-like permease family; Region: FtsX; pfam02687 717785001845 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 717785001846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785001847 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785001848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785001849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785001850 non-specific DNA binding site [nucleotide binding]; other site 717785001851 salt bridge; other site 717785001852 sequence-specific DNA binding site [nucleotide binding]; other site 717785001853 Cupin domain; Region: Cupin_2; cl09118 717785001854 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 717785001855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001856 dimer interface [polypeptide binding]; other site 717785001857 conserved gate region; other site 717785001858 putative PBP binding loops; other site 717785001859 ABC-ATPase subunit interface; other site 717785001860 sulfate transport protein; Provisional; Region: cysT; CHL00187 717785001861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785001862 dimer interface [polypeptide binding]; other site 717785001863 conserved gate region; other site 717785001864 putative PBP binding loops; other site 717785001865 ABC-ATPase subunit interface; other site 717785001866 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 717785001867 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 717785001868 Walker A/P-loop; other site 717785001869 ATP binding site [chemical binding]; other site 717785001870 Q-loop/lid; other site 717785001871 ABC transporter signature motif; other site 717785001872 Walker B; other site 717785001873 D-loop; other site 717785001874 H-loop/switch region; other site 717785001875 TOBE-like domain; Region: TOBE_3; pfam12857 717785001876 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785001877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001878 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 717785001879 substrate binding site [chemical binding]; other site 717785001880 dimerization interface [polypeptide binding]; other site 717785001881 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 717785001882 lipoyl synthase; Provisional; Region: PRK05481 717785001883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785001884 FeS/SAM binding site; other site 717785001885 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785001886 Cupin domain; Region: Cupin_2; cl09118 717785001887 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 717785001888 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 717785001889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785001890 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 717785001891 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 717785001892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785001893 putative substrate translocation pore; other site 717785001894 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785001895 putative acyl-acceptor binding pocket; other site 717785001896 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785001897 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 717785001898 thiS-thiF/thiG interaction site; other site 717785001899 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 717785001900 ThiS interaction site; other site 717785001901 putative active site [active] 717785001902 tetramer interface [polypeptide binding]; other site 717785001903 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 717785001904 thiamine phosphate binding site [chemical binding]; other site 717785001905 active site 717785001906 pyrophosphate binding site [ion binding]; other site 717785001907 CHAD domain; Region: CHAD; cl10506 717785001908 ferrochelatase; Reviewed; Region: hemH; PRK00035 717785001909 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 717785001910 C-terminal domain interface [polypeptide binding]; other site 717785001911 active site 717785001912 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 717785001913 active site 717785001914 N-terminal domain interface [polypeptide binding]; other site 717785001915 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 717785001916 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 717785001917 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 717785001918 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 717785001919 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 717785001920 putative active site [active] 717785001921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 717785001922 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 717785001923 active site 717785001924 tetramer interface [polypeptide binding]; other site 717785001925 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 717785001926 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 717785001927 NAD binding site [chemical binding]; other site 717785001928 homodimer interface [polypeptide binding]; other site 717785001929 active site 717785001930 substrate binding site [chemical binding]; other site 717785001931 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 717785001932 lytic murein transglycosylase; Region: MltB_2; TIGR02283 717785001933 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785001934 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717785001935 active site 717785001936 catalytic triad [active] 717785001937 oxyanion hole [active] 717785001938 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 717785001939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785001940 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 717785001941 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 717785001942 active site 717785001943 dimer interface [polypeptide binding]; other site 717785001944 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 717785001945 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 717785001946 active site 717785001947 FMN binding site [chemical binding]; other site 717785001948 substrate binding site [chemical binding]; other site 717785001949 3Fe-4S cluster binding site [ion binding]; other site 717785001950 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 717785001951 domain interface; other site 717785001952 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785001953 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 717785001954 putative dimer interface [polypeptide binding]; other site 717785001955 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 717785001956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785001957 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 717785001958 active site 717785001959 N-formylglutamate amidohydrolase; Region: FGase; cl01522 717785001960 Response regulator receiver domain; Region: Response_reg; pfam00072 717785001961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001962 active site 717785001963 phosphorylation site [posttranslational modification] 717785001964 intermolecular recognition site; other site 717785001965 dimerization interface [polypeptide binding]; other site 717785001966 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 717785001967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785001968 S-adenosylmethionine binding site [chemical binding]; other site 717785001969 Cupin domain; Region: Cupin_2; cl09118 717785001970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785001971 binding surface 717785001972 TPR motif; other site 717785001973 pyruvate kinase; Provisional; Region: PRK06247 717785001974 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785001975 domain interfaces; other site 717785001976 active site 717785001977 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 717785001978 MOFRL family; Region: MOFRL; cl01013 717785001979 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 717785001980 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 717785001981 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 717785001982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785001983 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 717785001984 dimerization interface [polypeptide binding]; other site 717785001985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 717785001986 Peptidase M15; Region: Peptidase_M15_3; cl01194 717785001987 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 717785001988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785001989 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785001990 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785001992 active site 717785001993 phosphorylation site [posttranslational modification] 717785001994 intermolecular recognition site; other site 717785001995 dimerization interface [polypeptide binding]; other site 717785001996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785001997 Walker A motif; other site 717785001998 ATP binding site [chemical binding]; other site 717785001999 Walker B motif; other site 717785002000 arginine finger; other site 717785002001 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785002002 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 717785002003 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 717785002004 active site 717785002005 Zn binding site [ion binding]; other site 717785002006 K+ potassium transporter; Region: K_trans; cl01227 717785002007 potassium uptake protein; Region: kup; TIGR00794 717785002008 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 717785002009 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1633824, 3525165; Product type e : enzyme 717785002010 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1633824, 3525165; Product type e : enzyme 717785002011 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 717785002012 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 717785002013 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785002014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785002015 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 717785002016 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785002017 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 717785002018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 717785002019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785002020 substrate binding pocket [chemical binding]; other site 717785002021 membrane-bound complex binding site; other site 717785002022 hinge residues; other site 717785002023 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 717785002024 DXD motif; other site 717785002025 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 717785002026 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 717785002027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785002028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785002029 S-adenosylmethionine binding site [chemical binding]; other site 717785002030 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 717785002031 putative acyl-acceptor binding pocket; other site 717785002032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785002033 metal binding site [ion binding]; metal-binding site 717785002034 active site 717785002035 I-site; other site 717785002036 Amidinotransferase; Region: Amidinotransf; cl12043 717785002037 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 717785002038 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 717785002039 Creatinine amidohydrolase; Region: Creatininase; cl00618 717785002040 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785002041 classical (c) SDRs; Region: SDR_c; cd05233 717785002042 NAD(P) binding site [chemical binding]; other site 717785002043 active site 717785002044 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785002045 classical (c) SDRs; Region: SDR_c; cd05233 717785002046 NAD(P) binding site [chemical binding]; other site 717785002047 active site 717785002048 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785002049 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785002050 Walker A/P-loop; other site 717785002051 ATP binding site [chemical binding]; other site 717785002052 Q-loop/lid; other site 717785002053 ABC transporter signature motif; other site 717785002054 Walker B; other site 717785002055 D-loop; other site 717785002056 H-loop/switch region; other site 717785002057 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785002058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785002059 dimer interface [polypeptide binding]; other site 717785002060 conserved gate region; other site 717785002061 putative PBP binding loops; other site 717785002062 ABC-ATPase subunit interface; other site 717785002063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785002064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785002065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785002066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785002067 dimerization interface [polypeptide binding]; other site 717785002068 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785002069 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785002070 Trp docking motif; other site 717785002071 'Velcro' closure; other site 717785002072 active site 717785002073 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 717785002074 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 717785002075 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 717785002076 Sodium:solute symporter family; Region: SSF; cl00456 717785002077 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 717785002078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785002079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785002080 Sel1 repeat; Region: Sel1; cl02723 717785002081 Sel1 repeat; Region: Sel1; cl02723 717785002082 Sel1 repeat; Region: Sel1; cl02723 717785002083 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785002084 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 717785002085 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 717785002086 putative active site [active] 717785002087 putative metal binding site [ion binding]; other site 717785002088 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 717785002089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785002090 ATP binding site [chemical binding]; other site 717785002091 putative Mg++ binding site [ion binding]; other site 717785002092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002093 nucleotide binding region [chemical binding]; other site 717785002094 ATP-binding site [chemical binding]; other site 717785002095 DEAD/H associated; Region: DEAD_assoc; pfam08494 717785002096 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 717785002097 quinone interaction residues [chemical binding]; other site 717785002098 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 717785002099 active site 717785002100 catalytic residues [active] 717785002101 FMN binding site [chemical binding]; other site 717785002102 substrate binding site [chemical binding]; other site 717785002103 Protein of unknown function (DUF952); Region: DUF952; cl01393 717785002104 Protein of unknown function DUF262; Region: DUF262; cl14890 717785002105 Protein of unknown function DUF262; Region: DUF262; cl14890 717785002106 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 717785002107 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785002108 active site 717785002109 nucleotide binding site [chemical binding]; other site 717785002110 HIGH motif; other site 717785002111 KMSKS motif; other site 717785002112 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 717785002113 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 717785002114 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 717785002115 integrase; Provisional; Region: PRK09692 717785002116 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785002117 active site 717785002118 Int/Topo IB signature motif; other site 717785002119 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717785002120 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 717785002121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785002122 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 717785002123 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 717785002124 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 717785002125 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 717785002126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785002127 ligand binding site [chemical binding]; other site 717785002128 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 717785002129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785002130 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785002131 CHASE3 domain; Region: CHASE3; cl05000 717785002132 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 717785002133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002134 ATP binding site [chemical binding]; other site 717785002135 Mg2+ binding site [ion binding]; other site 717785002136 G-X-G motif; other site 717785002137 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002139 active site 717785002140 phosphorylation site [posttranslational modification] 717785002141 intermolecular recognition site; other site 717785002142 dimerization interface [polypeptide binding]; other site 717785002143 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002145 active site 717785002146 phosphorylation site [posttranslational modification] 717785002147 intermolecular recognition site; other site 717785002148 dimerization interface [polypeptide binding]; other site 717785002149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785002150 Histidine kinase; Region: HisKA_2; cl06527 717785002151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002152 ATP binding site [chemical binding]; other site 717785002153 Mg2+ binding site [ion binding]; other site 717785002154 G-X-G motif; other site 717785002155 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 717785002156 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785002157 active site 717785002158 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 717785002159 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 717785002160 Autotransporter beta-domain; Region: Autotransporter; cl02365 717785002161 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480 717785002162 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 717785002163 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 717785002164 ATP binding site [chemical binding]; other site 717785002165 Mg++ binding site [ion binding]; other site 717785002166 motif III; other site 717785002167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002168 nucleotide binding region [chemical binding]; other site 717785002169 ATP-binding site [chemical binding]; other site 717785002170 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785002171 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 717785002172 Serine carboxypeptidase S28; Region: Peptidase_S28; pfam05577 717785002173 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480 717785002174 Domain of unknown function DUF302; Region: DUF302; cl01364 717785002175 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 717785002176 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 717785002177 active site 717785002178 substrate binding site [chemical binding]; other site 717785002179 coenzyme B12 binding site [chemical binding]; other site 717785002180 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 717785002181 B12 binding site [chemical binding]; other site 717785002182 cobalt ligand [ion binding]; other site 717785002183 Protein of unknown function (DUF817); Region: DUF817; cl01520 717785002184 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 717785002185 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 717785002186 putative ion selectivity filter; other site 717785002187 putative pore gating glutamate residue; other site 717785002188 putative H+/Cl- coupling transport residue; other site 717785002189 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 717785002190 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 717785002191 heterodimer interface [polypeptide binding]; other site 717785002192 substrate interaction site [chemical binding]; other site 717785002193 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 717785002194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785002195 Walker A motif; other site 717785002196 ATP binding site [chemical binding]; other site 717785002197 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785002198 nucleophile elbow; other site 717785002199 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785002200 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785002201 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785002202 K-box region; Region: K-box; pfam01486 717785002203 H-NS histone family; Region: Histone_HNS; pfam00816 717785002204 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 717785002205 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 717785002206 oligomerisation interface [polypeptide binding]; other site 717785002207 mobile loop; other site 717785002208 roof hairpin; other site 717785002209 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 717785002210 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 717785002211 ring oligomerisation interface [polypeptide binding]; other site 717785002212 ATP/Mg binding site [chemical binding]; other site 717785002213 stacking interactions; other site 717785002214 hinge regions; other site 717785002215 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 717785002216 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785002217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785002218 S-adenosylmethionine binding site [chemical binding]; other site 717785002219 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 717785002220 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 717785002221 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785002222 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 717785002223 putative active site [active] 717785002224 putative metal binding site [ion binding]; other site 717785002225 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 717785002226 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 717785002227 active site 717785002228 NTP binding site [chemical binding]; other site 717785002229 metal binding triad [ion binding]; metal-binding site 717785002230 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 717785002231 putative active site [active] 717785002232 putative CoA binding site [chemical binding]; other site 717785002233 nudix motif; other site 717785002234 metal binding site [ion binding]; metal-binding site 717785002235 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 717785002236 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 717785002237 FMN binding site [chemical binding]; other site 717785002238 active site 717785002239 substrate binding site [chemical binding]; other site 717785002240 catalytic residue [active] 717785002241 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 717785002242 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 717785002243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785002244 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785002245 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 717785002246 Walker A/P-loop; other site 717785002247 ATP binding site [chemical binding]; other site 717785002248 Q-loop/lid; other site 717785002249 ABC transporter signature motif; other site 717785002250 Walker B; other site 717785002251 D-loop; other site 717785002252 H-loop/switch region; other site 717785002253 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 717785002254 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 717785002255 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 717785002256 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 717785002257 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 717785002258 [2Fe-2S] cluster binding site [ion binding]; other site 717785002259 cytochrome b; Provisional; Region: CYTB; MTH00119 717785002260 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 717785002261 Qi binding site; other site 717785002262 intrachain domain interface; other site 717785002263 interchain domain interface [polypeptide binding]; other site 717785002264 heme bH binding site [chemical binding]; other site 717785002265 heme bL binding site [chemical binding]; other site 717785002266 Qo binding site; other site 717785002267 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 717785002268 interchain domain interface [polypeptide binding]; other site 717785002269 intrachain domain interface; other site 717785002270 Qi binding site; other site 717785002271 Qo binding site; other site 717785002272 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 717785002273 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 717785002274 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785002275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785002276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785002277 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 717785002278 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 717785002279 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 717785002280 intersubunit interface [polypeptide binding]; other site 717785002281 active site 717785002282 Zn2+ binding site [ion binding]; other site 717785002283 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 717785002284 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 717785002285 tetramer interface [polypeptide binding]; other site 717785002286 heme binding pocket [chemical binding]; other site 717785002287 NADPH binding site [chemical binding]; other site 717785002288 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 717785002289 GTP-binding protein YchF; Reviewed; Region: PRK09601 717785002290 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 717785002291 G1 box; other site 717785002292 GTP/Mg2+ binding site [chemical binding]; other site 717785002293 Switch I region; other site 717785002294 G2 box; other site 717785002295 Switch II region; other site 717785002296 G3 box; other site 717785002297 G4 box; other site 717785002298 G5 box; other site 717785002299 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 717785002300 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 717785002301 putative active site [active] 717785002302 catalytic residue [active] 717785002303 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 717785002304 5S rRNA interface [nucleotide binding]; other site 717785002305 CTC domain interface; other site 717785002306 L16 interface [polypeptide binding]; other site 717785002307 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785002308 metal binding site 2 [ion binding]; metal-binding site 717785002309 putative DNA binding helix; other site 717785002310 metal binding site 1 [ion binding]; metal-binding site 717785002311 dimer interface [polypeptide binding]; other site 717785002312 structural Zn2+ binding site [ion binding]; other site 717785002313 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785002314 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 717785002315 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 717785002316 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 717785002317 Uncharacterized conserved protein [Function unknown]; Region: COG1565 717785002318 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 717785002319 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 717785002320 Membrane fusogenic activity; Region: BMFP; cl01115 717785002321 Family of unknown function (DUF1790); Region: DUF1790; cl02283 717785002322 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 717785002323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002324 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785002325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785002326 dimer interface [polypeptide binding]; other site 717785002327 phosphorylation site [posttranslational modification] 717785002328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002329 ATP binding site [chemical binding]; other site 717785002330 Mg2+ binding site [ion binding]; other site 717785002331 G-X-G motif; other site 717785002332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002334 active site 717785002335 phosphorylation site [posttranslational modification] 717785002336 intermolecular recognition site; other site 717785002337 dimerization interface [polypeptide binding]; other site 717785002338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785002339 DNA binding site [nucleotide binding] 717785002340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785002341 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 717785002342 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 717785002343 homodimer interface [polypeptide binding]; other site 717785002344 substrate-cofactor binding pocket; other site 717785002345 catalytic residue [active] 717785002346 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 717785002347 dimer interface [polypeptide binding]; other site 717785002348 ligand binding site [chemical binding]; other site 717785002349 RF-1 domain; Region: RF-1; cl02875 717785002350 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 717785002351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785002352 S-adenosylmethionine binding site [chemical binding]; other site 717785002353 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 717785002354 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 717785002355 Ligand Binding Site [chemical binding]; other site 717785002356 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 717785002357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002359 active site 717785002360 phosphorylation site [posttranslational modification] 717785002361 intermolecular recognition site; other site 717785002362 dimerization interface [polypeptide binding]; other site 717785002363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785002364 DNA binding site [nucleotide binding] 717785002365 Surface antigen; Region: Surface_Ag_2; cl01155 717785002366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785002367 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 717785002368 catalytic core [active] 717785002369 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 717785002370 catalytic core [active] 717785002371 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 717785002372 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 717785002373 proposed catalytic triad [active] 717785002374 conserved cys residue [active] 717785002375 excinuclease ABC subunit B; Provisional; Region: PRK05298 717785002376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785002377 ATP binding site [chemical binding]; other site 717785002378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002379 nucleotide binding region [chemical binding]; other site 717785002380 ATP-binding site [chemical binding]; other site 717785002381 Ultra-violet resistance protein B; Region: UvrB; pfam12344 717785002382 UvrB/uvrC motif; Region: UVR; pfam02151 717785002383 short chain dehydrogenase; Provisional; Region: PRK12828 717785002384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002385 NAD(P) binding site [chemical binding]; other site 717785002386 active site 717785002387 aspartate aminotransferase; Provisional; Region: PRK08361 717785002388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785002389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785002390 homodimer interface [polypeptide binding]; other site 717785002391 catalytic residue [active] 717785002392 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 717785002393 elongation factor G; Reviewed; Region: PRK12740 717785002394 G1 box; other site 717785002395 putative GEF interaction site [polypeptide binding]; other site 717785002396 GTP/Mg2+ binding site [chemical binding]; other site 717785002397 Switch I region; other site 717785002398 G2 box; other site 717785002399 G3 box; other site 717785002400 Switch II region; other site 717785002401 G4 box; other site 717785002402 G5 box; other site 717785002403 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 717785002404 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 717785002405 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 717785002406 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 717785002407 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 717785002408 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 717785002409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785002410 catalytic loop [active] 717785002411 iron binding site [ion binding]; other site 717785002412 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 717785002413 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 717785002414 [4Fe-4S] binding site [ion binding]; other site 717785002415 molybdopterin cofactor binding site; other site 717785002416 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 717785002417 molybdopterin cofactor binding site; other site 717785002418 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 717785002419 putative dimer interface [polypeptide binding]; other site 717785002420 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 717785002421 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 717785002422 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 717785002423 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 717785002424 putative dimer interface [polypeptide binding]; other site 717785002425 [2Fe-2S] cluster binding site [ion binding]; other site 717785002426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785002427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785002428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785002429 dimerization interface [polypeptide binding]; other site 717785002430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002431 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785002432 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 717785002433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785002434 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 717785002435 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 717785002436 NAD(P) binding site [chemical binding]; other site 717785002437 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 717785002438 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 717785002439 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 717785002440 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 717785002441 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785002442 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 717785002443 Walker A/P-loop; other site 717785002444 ATP binding site [chemical binding]; other site 717785002445 Q-loop/lid; other site 717785002446 ABC transporter signature motif; other site 717785002447 Walker B; other site 717785002448 D-loop; other site 717785002449 H-loop/switch region; other site 717785002450 hypothetical protein; Validated; Region: PRK09039 717785002451 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002452 ligand binding site [chemical binding]; other site 717785002453 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 717785002454 active site 717785002455 dimerization interface [polypeptide binding]; other site 717785002456 Sel1 repeat; Region: Sel1; cl02723 717785002457 Sel1 repeat; Region: Sel1; cl02723 717785002458 Sel1 repeat; Region: Sel1; cl02723 717785002459 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785002460 Sel1 repeat; Region: Sel1; cl02723 717785002461 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 717785002462 active site 717785002463 thiamine phosphate binding site [chemical binding]; other site 717785002464 pyrophosphate binding site [ion binding]; other site 717785002465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785002466 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785002467 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 717785002468 active site 717785002469 intersubunit interface [polypeptide binding]; other site 717785002470 catalytic residue [active] 717785002471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785002472 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 717785002473 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 717785002474 Cell division protein ZapA; Region: ZapA; cl01146 717785002475 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 717785002476 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785002477 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 717785002478 putative active site [active] 717785002479 metal binding site [ion binding]; metal-binding site 717785002480 homodimer binding site [polypeptide binding]; other site 717785002481 Domain of unknown function DUF28; Region: DUF28; cl00361 717785002482 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 717785002483 active site 717785002484 putative DNA-binding cleft [nucleotide binding]; other site 717785002485 dimer interface [polypeptide binding]; other site 717785002486 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 717785002487 RuvA N terminal domain; Region: RuvA_N; pfam01330 717785002488 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 717785002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785002490 Walker A motif; other site 717785002491 ATP binding site [chemical binding]; other site 717785002492 Walker B motif; other site 717785002493 arginine finger; other site 717785002494 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 717785002495 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 717785002496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 717785002497 putative active site [active] 717785002498 putative metal binding site [ion binding]; other site 717785002499 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 717785002500 active site 717785002501 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785002502 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 717785002503 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 717785002504 translocation protein TolB; Provisional; Region: tolB; PRK05137 717785002505 TolB amino-terminal domain; Region: TolB_N; pfam04052 717785002506 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002507 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002508 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 717785002509 putative outer membrane lipoprotein; Provisional; Region: PRK09967 717785002510 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002511 ligand binding site [chemical binding]; other site 717785002512 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002513 ligand binding site [chemical binding]; other site 717785002514 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 717785002515 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 717785002516 Ligand Binding Site [chemical binding]; other site 717785002517 FtsH Extracellular; Region: FtsH_ext; pfam06480 717785002518 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 717785002519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785002520 Walker A motif; other site 717785002521 ATP binding site [chemical binding]; other site 717785002522 Walker B motif; other site 717785002523 arginine finger; other site 717785002524 Peptidase family M41; Region: Peptidase_M41; pfam01434 717785002525 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 717785002526 dihydropteroate synthase; Region: DHPS; TIGR01496 717785002527 substrate binding pocket [chemical binding]; other site 717785002528 dimer interface [polypeptide binding]; other site 717785002529 inhibitor binding site; inhibition site 717785002530 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785002531 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 717785002532 putative C-terminal domain interface [polypeptide binding]; other site 717785002533 putative GSH binding site (G-site) [chemical binding]; other site 717785002534 putative dimer interface [polypeptide binding]; other site 717785002535 GST_C family, unknown subfamily 7; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_7; cd03206 717785002536 putative N-terminal domain interface [polypeptide binding]; other site 717785002537 putative dimer interface [polypeptide binding]; other site 717785002538 putative substrate binding pocket (H-site) [chemical binding]; other site 717785002539 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717785002540 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785002541 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785002542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785002543 P-loop; other site 717785002544 Magnesium ion binding site [ion binding]; other site 717785002545 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785002546 Magnesium ion binding site [ion binding]; other site 717785002547 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 717785002548 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 717785002549 active site 717785002550 substrate binding site [chemical binding]; other site 717785002551 metal binding site [ion binding]; metal-binding site 717785002552 Surface antigen; Region: Surface_Ag_2; cl01155 717785002553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 717785002554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002555 catalytic residue [active] 717785002556 conserved hypothetical protein; Region: TIGR02231 717785002557 adenylosuccinate synthetase; Provisional; Region: PRK01117 717785002558 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 717785002559 GDP-binding site [chemical binding]; other site 717785002560 ACT binding site; other site 717785002561 IMP binding site; other site 717785002562 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717785002563 putative active site [active] 717785002564 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002565 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002566 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002567 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002568 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 717785002569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785002570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 717785002571 nudix motif; other site 717785002572 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 717785002573 putative active site [active] 717785002574 putative metal binding site [ion binding]; other site 717785002575 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785002576 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785002577 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785002578 active site 717785002579 nucleophile elbow; other site 717785002580 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785002581 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 717785002582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 717785002583 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 717785002584 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 717785002585 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 717785002586 Chromate transporter; Region: Chromate_transp; pfam02417 717785002587 Chromate transporter; Region: Chromate_transp; pfam02417 717785002588 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 717785002589 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 717785002590 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 717785002591 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785002592 Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is...; Region: GST_N_Metaxin_like; cd03080 717785002593 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785002594 putative C-terminal domain interface [polypeptide binding]; other site 717785002595 putative GSH binding site [chemical binding]; other site 717785002596 putative dimer interface [polypeptide binding]; other site 717785002597 GST_C family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its...; Region: GST_C_Metaxin; cd03193 717785002598 putative N-terminal domain interface [polypeptide binding]; other site 717785002599 ThiC family; Region: ThiC; cl08031 717785002600 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 717785002601 TfoX N-terminal domain; Region: TfoX_N; cl01167 717785002602 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 717785002603 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 717785002604 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 717785002605 Aerotolerance regulator N-terminal; Region: BatA; cl06567 717785002606 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 717785002607 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 717785002608 Protein of unknown function DUF58; Region: DUF58; pfam01882 717785002609 MoxR-like ATPases [General function prediction only]; Region: COG0714 717785002610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785002611 Walker A motif; other site 717785002612 ATP binding site [chemical binding]; other site 717785002613 Walker B motif; other site 717785002614 arginine finger; other site 717785002615 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 717785002616 Protein of unknown function DUF262; Region: DUF262; cl14890 717785002617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785002618 Coenzyme A binding pocket [chemical binding]; other site 717785002619 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785002620 DNA-binding site [nucleotide binding]; DNA binding site 717785002621 RNA-binding motif; other site 717785002622 Acyltransferase family; Region: Acyl_transf_3; pfam01757 717785002623 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 717785002624 Multicopper oxidase; Region: Cu-oxidase; cl14658 717785002625 Multicopper oxidase; Region: Cu-oxidase; cl14658 717785002626 Multicopper oxidase; Region: Cu-oxidase; cl14658 717785002627 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 717785002628 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 717785002629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785002630 Histidine kinase; Region: HisKA_2; cl06527 717785002631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002632 ATP binding site [chemical binding]; other site 717785002633 Mg2+ binding site [ion binding]; other site 717785002634 G-X-G motif; other site 717785002635 Usg-like family; Region: Usg; cl11567 717785002636 MarC family integral membrane protein; Region: MarC; cl00919 717785002637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785002638 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 717785002639 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 717785002640 catalytic triad [active] 717785002641 Predicted membrane protein [Function unknown]; Region: COG3164 717785002642 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 717785002643 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 717785002644 active site 717785002645 HIGH motif; other site 717785002646 dimer interface [polypeptide binding]; other site 717785002647 KMSKS motif; other site 717785002648 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 717785002649 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 717785002650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785002651 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785002652 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785002653 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785002654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002655 catalytic residue [active] 717785002656 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 717785002657 putative ABC transporter; Region: ycf24; CHL00085 717785002658 FeS assembly ATPase SufC; Region: sufC; TIGR01978 717785002659 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 717785002660 Walker A/P-loop; other site 717785002661 ATP binding site [chemical binding]; other site 717785002662 Q-loop/lid; other site 717785002663 ABC transporter signature motif; other site 717785002664 Walker B; other site 717785002665 D-loop; other site 717785002666 H-loop/switch region; other site 717785002667 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 717785002668 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 717785002669 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785002670 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785002671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785002672 catalytic residue [active] 717785002673 Domain of unknown function DUF59; Region: DUF59; cl00941 717785002674 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 717785002675 TfoX N-terminal domain; Region: TfoX_N; cl01167 717785002676 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 717785002677 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 717785002678 ATP binding site [chemical binding]; other site 717785002679 Mg++ binding site [ion binding]; other site 717785002680 motif III; other site 717785002681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785002682 nucleotide binding region [chemical binding]; other site 717785002683 ATP-binding site [chemical binding]; other site 717785002684 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 717785002685 amphipathic channel; other site 717785002686 Asn-Pro-Ala signature motifs; other site 717785002687 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 717785002688 Fatty acid desaturase; Region: FA_desaturase; pfam00487 717785002689 putative di-iron ligands [ion binding]; other site 717785002690 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 717785002691 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 717785002692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717785002693 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 717785002694 anchoring element; other site 717785002695 dimer interface [polypeptide binding]; other site 717785002696 ATP binding site [chemical binding]; other site 717785002697 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both...; Region: TOPRIM_TopoIIA_like; cd01030 717785002698 active site 717785002699 putative metal-binding site [ion binding]; other site 717785002700 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 717785002701 Pantoate-beta-alanine ligase; Region: PanC; cd00560 717785002702 pantoate--beta-alanine ligase; Region: panC; TIGR00018 717785002703 active site 717785002704 ATP-binding site [chemical binding]; other site 717785002705 pantoate-binding site; other site 717785002706 HXXH motif; other site 717785002707 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 717785002708 Proline dehydrogenase; Region: Pro_dh; cl03282 717785002709 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 717785002710 Glutamate binding site [chemical binding]; other site 717785002711 NAD binding site [chemical binding]; other site 717785002712 catalytic residues [active] 717785002713 Cupin domain; Region: Cupin_2; cl09118 717785002714 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 717785002715 Beta-lactamase; Region: Beta-lactamase; cl01009 717785002716 Sporulation related domain; Region: SPOR; cl10051 717785002717 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 717785002718 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 717785002719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785002720 Walker A motif; other site 717785002721 ATP binding site [chemical binding]; other site 717785002722 Walker B motif; other site 717785002723 arginine finger; other site 717785002724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785002725 Walker A motif; other site 717785002726 ATP binding site [chemical binding]; other site 717785002727 Walker B motif; other site 717785002728 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785002729 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 717785002730 NAD binding site [chemical binding]; other site 717785002731 substrate binding site [chemical binding]; other site 717785002732 putative active site [active] 717785002733 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 717785002734 HIT family signature motif; other site 717785002735 catalytic residue [active] 717785002736 FemAB family; Region: FemAB; cl11444 717785002737 Protein of unknown function, DUF482; Region: DUF482; pfam04339 717785002738 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 717785002739 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 717785002740 active site 717785002741 catalytic site [active] 717785002742 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 717785002743 homotrimer interaction site [polypeptide binding]; other site 717785002744 putative active site [active] 717785002745 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 717785002746 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 717785002747 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002749 active site 717785002750 phosphorylation site [posttranslational modification] 717785002751 intermolecular recognition site; other site 717785002752 dimerization interface [polypeptide binding]; other site 717785002753 response regulator PleD; Reviewed; Region: pleD; PRK09581 717785002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002755 active site 717785002756 phosphorylation site [posttranslational modification] 717785002757 intermolecular recognition site; other site 717785002758 dimerization interface [polypeptide binding]; other site 717785002759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002760 active site 717785002761 phosphorylation site [posttranslational modification] 717785002762 intermolecular recognition site; other site 717785002763 dimerization interface [polypeptide binding]; other site 717785002764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785002765 metal binding site [ion binding]; metal-binding site 717785002766 active site 717785002767 I-site; other site 717785002768 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 717785002769 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 717785002770 nudix motif; other site 717785002771 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785002772 ribonuclease R; Region: RNase_R; TIGR02063 717785002773 RNB domain; Region: RNB; pfam00773 717785002774 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 717785002775 RNA binding site [nucleotide binding]; other site 717785002776 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 717785002777 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 717785002778 active site 717785002779 interdomain interaction site; other site 717785002780 putative metal-binding site [ion binding]; other site 717785002781 nucleotide binding site [chemical binding]; other site 717785002782 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 717785002783 domain I; other site 717785002784 DNA binding groove [nucleotide binding] 717785002785 phosphate binding site [ion binding]; other site 717785002786 domain II; other site 717785002787 domain III; other site 717785002788 nucleotide binding site [chemical binding]; other site 717785002789 catalytic site [active] 717785002790 domain IV; other site 717785002791 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 717785002792 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 717785002793 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 717785002794 Domain of unknown function (DUF205); Region: DUF205; cl00410 717785002795 dihydroorotase; Validated; Region: PRK09059 717785002796 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 717785002797 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 717785002798 active site 717785002799 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 717785002800 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785002801 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785002802 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 717785002803 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 717785002804 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 717785002805 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 717785002806 Chorismate mutase type II; Region: CM_2; cl00693 717785002807 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 717785002808 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 717785002809 GatB domain; Region: GatB_Yqey; cl11497 717785002810 Cytochrome P450; Region: p450; cl12078 717785002811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 717785002812 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 717785002813 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 717785002814 NADP binding site [chemical binding]; other site 717785002815 dimer interface [polypeptide binding]; other site 717785002816 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 717785002817 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 717785002818 C-terminal domain interface [polypeptide binding]; other site 717785002819 GSH binding site (G-site) [chemical binding]; other site 717785002820 dimer interface [polypeptide binding]; other site 717785002821 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 717785002822 dimer interface [polypeptide binding]; other site 717785002823 N-terminal domain interface [polypeptide binding]; other site 717785002824 putative substrate binding pocket (H-site) [chemical binding]; other site 717785002825 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785002826 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 717785002827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002828 active site 717785002829 phosphorylation site [posttranslational modification] 717785002830 intermolecular recognition site; other site 717785002831 dimerization interface [polypeptide binding]; other site 717785002832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785002833 DNA binding residues [nucleotide binding] 717785002834 dimerization interface [polypeptide binding]; other site 717785002835 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785002836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785002837 putative active site [active] 717785002838 heme pocket [chemical binding]; other site 717785002839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785002840 dimer interface [polypeptide binding]; other site 717785002841 phosphorylation site [posttranslational modification] 717785002842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785002843 ATP binding site [chemical binding]; other site 717785002844 Mg2+ binding site [ion binding]; other site 717785002845 G-X-G motif; other site 717785002846 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785002847 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 717785002848 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 717785002849 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785002850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785002851 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 717785002852 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 717785002853 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785002854 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785002855 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785002856 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785002857 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785002858 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 717785002859 Cytochrome c; Region: Cytochrom_C; cl11414 717785002860 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 717785002861 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785002862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785002863 ligand binding site [chemical binding]; other site 717785002864 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785002865 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785002866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785002867 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 717785002868 N-acetyl-D-glucosamine binding site [chemical binding]; other site 717785002869 catalytic residue [active] 717785002870 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 717785002871 dihydrodipicolinate synthase; Region: dapA; TIGR00674 717785002872 dimer interface [polypeptide binding]; other site 717785002873 active site 717785002874 catalytic residue [active] 717785002875 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 717785002876 SmpB-tmRNA interface; other site 717785002877 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 717785002878 catalytic triad [active] 717785002879 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 717785002880 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 717785002881 putative metal binding site [ion binding]; other site 717785002882 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 717785002883 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 717785002884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 717785002885 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 717785002886 synthetase active site [active] 717785002887 NTP binding site [chemical binding]; other site 717785002888 metal binding site [ion binding]; metal-binding site 717785002889 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 717785002890 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 717785002891 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 717785002892 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 717785002893 active site 717785002894 hydrophilic channel; other site 717785002895 dimerization interface [polypeptide binding]; other site 717785002896 catalytic residues [active] 717785002897 active site lid [active] 717785002898 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 717785002899 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 717785002900 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 717785002901 Catalytic site [active] 717785002902 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 717785002903 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 717785002904 ribonuclease III; Reviewed; Region: rnc; PRK00102 717785002905 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 717785002906 dimerization interface [polypeptide binding]; other site 717785002907 active site 717785002908 metal binding site [ion binding]; metal-binding site 717785002909 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 717785002910 dsRNA binding site [nucleotide binding]; other site 717785002911 GTPase Era; Reviewed; Region: era; PRK00089 717785002912 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 717785002913 G1 box; other site 717785002914 GTP/Mg2+ binding site [chemical binding]; other site 717785002915 Switch I region; other site 717785002916 G2 box; other site 717785002917 Switch II region; other site 717785002918 G3 box; other site 717785002919 G4 box; other site 717785002920 G5 box; other site 717785002921 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 717785002922 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 717785002923 Recombination protein O N terminal; Region: RecO_N; pfam11967 717785002924 Recombination protein O C terminal; Region: RecO_C; pfam02565 717785002925 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 717785002926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785002927 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785002928 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 717785002929 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 717785002930 carboxyltransferase (CT) interaction site; other site 717785002931 biotinylation site [posttranslational modification]; other site 717785002932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785002933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785002934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785002935 dimerization interface [polypeptide binding]; other site 717785002936 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 717785002937 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785002938 Phage integrase family; Region: Phage_integrase; pfam00589 717785002939 DNA binding site [nucleotide binding] 717785002940 Int/Topo IB signature motif; other site 717785002941 active site 717785002942 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717785002943 Protein of unknown function (DUF968); Region: DUF968; pfam06147 717785002944 ERF superfamily; Region: ERF; pfam04404 717785002945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785002946 non-specific DNA binding site [nucleotide binding]; other site 717785002947 salt bridge; other site 717785002948 sequence-specific DNA binding site [nucleotide binding]; other site 717785002949 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 717785002950 Catalytic site [active] 717785002951 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 717785002952 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785002953 Phage terminase large subunit; Region: Terminase_3; cl12054 717785002954 Terminase-like family; Region: Terminase_6; pfam03237 717785002955 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 717785002956 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 717785002957 catalytic residue [active] 717785002958 T5orf172 domain; Region: T5orf172; pfam10544 717785002959 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785002960 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785002961 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 717785002962 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785002963 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785002964 active site 717785002965 nucleophile elbow; other site 717785002966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785002967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785002968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785002969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785002970 Response regulator receiver domain; Region: Response_reg; pfam00072 717785002971 active site 717785002972 phosphorylation site [posttranslational modification] 717785002973 intermolecular recognition site; other site 717785002974 dimerization interface [polypeptide binding]; other site 717785002975 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785002976 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 717785002977 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785002978 protein binding site [polypeptide binding]; other site 717785002979 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785002980 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 717785002981 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785002982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785002983 Coenzyme A binding pocket [chemical binding]; other site 717785002984 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 717785002985 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 717785002986 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 717785002987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785002989 homodimer interface [polypeptide binding]; other site 717785002990 catalytic residue [active] 717785002991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785002992 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 717785002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785002994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785002995 putative substrate translocation pore; other site 717785002996 glutamine synthetase; Provisional; Region: glnA; PRK09469 717785002997 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 717785002998 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785002999 Nitrogen regulatory protein P-II; Region: P-II; cl00412 717785003000 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 717785003001 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 717785003002 putative substrate binding site [chemical binding]; other site 717785003003 putative ATP binding site [chemical binding]; other site 717785003004 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 717785003005 active site 717785003006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003007 binding surface 717785003008 TPR motif; other site 717785003009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003010 TPR motif; other site 717785003011 binding surface 717785003012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003013 TPR motif; other site 717785003014 binding surface 717785003015 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 717785003016 DNA photolyase; Region: DNA_photolyase; pfam00875 717785003017 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 717785003018 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785003019 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 717785003020 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 717785003021 SelR domain; Region: SelR; cl00369 717785003022 Protein of unknown function DUF72; Region: DUF72; cl00777 717785003023 Gram-negative bacterial tonB protein; Region: TonB; cl10048 717785003024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785003025 metal binding site [ion binding]; metal-binding site 717785003026 active site 717785003027 I-site; other site 717785003028 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785003029 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785003030 NADP binding site [chemical binding]; other site 717785003031 active site 717785003032 steroid binding site; other site 717785003033 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 717785003034 active site clefts [active] 717785003035 zinc binding site [ion binding]; other site 717785003036 dimer interface [polypeptide binding]; other site 717785003037 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 717785003038 Beta-lactamase; Region: Beta-lactamase; cl01009 717785003039 Cytochrome c; Region: Cytochrom_C; cl11414 717785003040 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785003041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785003042 motif II; other site 717785003043 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785003044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785003046 Active site [active] 717785003047 calcium/proton exchanger (cax); Region: cax; TIGR00378 717785003048 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 717785003049 high affinity sulphate transporter 1; Region: sulP; TIGR00815 717785003050 Sulfate transporter family; Region: Sulfate_transp; cl00967 717785003051 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 717785003052 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 717785003053 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 717785003054 PhnA protein; Region: PhnA; pfam03831 717785003055 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 717785003056 dimer interface [polypeptide binding]; other site 717785003057 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 717785003058 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 717785003059 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 717785003060 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 717785003061 putative cation:proton antiport protein; Provisional; Region: PRK10669 717785003062 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 717785003063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003064 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 717785003065 Flagellin N-methylase; Region: FliB; cl00497 717785003066 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 717785003067 dimer interface [polypeptide binding]; other site 717785003068 ssDNA binding site [nucleotide binding]; other site 717785003069 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785003070 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 717785003071 Cation efflux family; Region: Cation_efflux; cl00316 717785003072 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 717785003073 active site 717785003074 Surface antigen; Region: Surface_Ag_2; cl01155 717785003075 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785003076 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 717785003077 putative switch regulator; other site 717785003078 non-specific DNA interactions [nucleotide binding]; other site 717785003079 DNA binding site [nucleotide binding] 717785003080 sequence specific DNA binding site [nucleotide binding]; other site 717785003081 putative cAMP binding site [chemical binding]; other site 717785003082 DNA gyrase subunit A; Validated; Region: PRK05560 717785003083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 717785003084 CAP-like domain; other site 717785003085 Active site [active] 717785003086 primary dimer interface [polypeptide binding]; other site 717785003087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 717785003093 Cytochrome c; Region: Cytochrom_C; cl11414 717785003094 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 717785003095 active site 717785003096 (T/H)XGH motif; other site 717785003097 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 717785003098 active site 717785003099 DNA binding site [nucleotide binding] 717785003100 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717785003101 active site 717785003102 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 717785003103 active site 717785003104 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 717785003105 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 717785003106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785003107 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785003108 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 717785003109 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 717785003110 ChaB; Region: ChaB; cl01887 717785003111 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 717785003112 MASE1; Region: MASE1; pfam05231 717785003113 PAS fold; Region: PAS_7; pfam12860 717785003114 diguanylate cyclase; Provisional; Region: PRK09894 717785003115 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785003116 metal binding site [ion binding]; metal-binding site 717785003117 active site 717785003118 I-site; other site 717785003119 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785003120 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 717785003121 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 717785003122 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 717785003123 malonyl-CoA binding site [chemical binding]; other site 717785003124 dimer interface [polypeptide binding]; other site 717785003125 active site 717785003126 product binding site; other site 717785003127 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003129 putative substrate translocation pore; other site 717785003130 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 717785003131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003132 NAD(P) binding site [chemical binding]; other site 717785003133 active site 717785003134 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 717785003135 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 717785003136 nucleophile elbow; other site 717785003137 Patatin phospholipase; Region: DUF3734; pfam12536 717785003138 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003140 putative substrate translocation pore; other site 717785003141 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785003142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785003143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785003144 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 717785003145 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 717785003146 active site 717785003147 dimer interface [polypeptide binding]; other site 717785003148 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 717785003149 Ligand Binding Site [chemical binding]; other site 717785003150 Molecular Tunnel; other site 717785003151 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 717785003152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785003153 Walker A motif; other site 717785003154 ATP binding site [chemical binding]; other site 717785003155 Walker B motif; other site 717785003156 arginine finger; other site 717785003157 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 717785003158 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 717785003159 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785003160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785003161 dimer interface [polypeptide binding]; other site 717785003162 phosphorylation site [posttranslational modification] 717785003163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003164 ATP binding site [chemical binding]; other site 717785003165 Mg2+ binding site [ion binding]; other site 717785003166 G-X-G motif; other site 717785003167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003168 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003169 active site 717785003170 phosphorylation site [posttranslational modification] 717785003171 intermolecular recognition site; other site 717785003172 dimerization interface [polypeptide binding]; other site 717785003173 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 717785003174 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 717785003175 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 717785003176 hexamer interface [polypeptide binding]; other site 717785003177 Walker A motif; other site 717785003178 ATP binding site [chemical binding]; other site 717785003179 Walker B motif; other site 717785003180 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 717785003181 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 717785003182 motif 1; other site 717785003183 active site 717785003184 motif 2; other site 717785003185 motif 3; other site 717785003186 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 717785003187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785003188 S-adenosylmethionine binding site [chemical binding]; other site 717785003189 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 717785003190 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 717785003191 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 717785003192 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 717785003193 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 717785003194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785003195 RNA binding surface [nucleotide binding]; other site 717785003196 Paraquat-inducible protein A; Region: PqiA; pfam04403 717785003197 Paraquat-inducible protein A; Region: PqiA; pfam04403 717785003198 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 717785003199 homodimer interface [polypeptide binding]; other site 717785003200 homotetramer interface [polypeptide binding]; other site 717785003201 active site pocket [active] 717785003202 cleavage site 717785003203 MEKHLA domain; Region: MEKHLA; pfam08670 717785003204 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 717785003205 putative GSH binding site [chemical binding]; other site 717785003206 catalytic residues [active] 717785003207 BolA-like protein; Region: BolA; cl00386 717785003208 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 717785003209 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 717785003210 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 717785003211 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 717785003212 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 717785003213 dimerization interface [polypeptide binding]; other site 717785003214 ATP binding site [chemical binding]; other site 717785003215 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 717785003216 dimerization interface [polypeptide binding]; other site 717785003217 ATP binding site [chemical binding]; other site 717785003218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 717785003219 Domain of unknown function (DUF305); Region: DUF305; pfam03713 717785003220 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 717785003221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003222 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 717785003223 dimerization interface [polypeptide binding]; other site 717785003224 substrate binding pocket [chemical binding]; other site 717785003225 Membrane transport protein; Region: Mem_trans; cl09117 717785003226 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 717785003227 putative active site [active] 717785003228 catalytic triad [active] 717785003229 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 717785003230 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 717785003231 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 717785003232 ATP binding site [chemical binding]; other site 717785003233 active site 717785003234 substrate binding site [chemical binding]; other site 717785003235 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 717785003236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785003237 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 717785003238 dimerization interface [polypeptide binding]; other site 717785003239 metal binding site [ion binding]; metal-binding site 717785003240 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 717785003241 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 717785003242 Ligand binding site [chemical binding]; other site 717785003243 Putative Catalytic site [active] 717785003244 DXD motif; other site 717785003245 GtrA-like protein; Region: GtrA; cl00971 717785003246 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785003247 active site 717785003248 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785003249 active site 717785003250 adenylosuccinate lyase; Provisional; Region: PRK07492 717785003251 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 717785003252 tetramer interface [polypeptide binding]; other site 717785003253 active site 717785003254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785003255 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 717785003256 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785003257 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 717785003258 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 717785003259 membrane ATPase/protein kinase; Provisional; Region: PRK09435 717785003260 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 717785003261 Walker A; other site 717785003262 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785003263 G4 box; other site 717785003264 G5 box; other site 717785003265 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 717785003266 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 717785003267 putative peptidoglycan binding site; other site 717785003268 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785003269 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 717785003270 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 717785003271 Walker A/P-loop; other site 717785003272 ATP binding site [chemical binding]; other site 717785003273 Q-loop/lid; other site 717785003274 ABC transporter signature motif; other site 717785003275 Walker B; other site 717785003276 D-loop; other site 717785003277 H-loop/switch region; other site 717785003278 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785003279 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 717785003280 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 717785003281 IPP transferase; Region: IPPT; cl00403 717785003282 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 717785003283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 717785003284 PYR/PP interface [polypeptide binding]; other site 717785003285 dimer interface [polypeptide binding]; other site 717785003286 TPP binding site [chemical binding]; other site 717785003287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785003288 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 717785003289 TPP-binding site [chemical binding]; other site 717785003290 dimer interface [polypeptide binding]; other site 717785003291 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 717785003292 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785003293 putative C-terminal domain interface [polypeptide binding]; other site 717785003294 putative GSH binding site (G-site) [chemical binding]; other site 717785003295 putative dimer interface [polypeptide binding]; other site 717785003296 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 717785003297 putative N-terminal domain interface [polypeptide binding]; other site 717785003298 putative dimer interface [polypeptide binding]; other site 717785003299 putative substrate binding pocket (H-site) [chemical binding]; other site 717785003300 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 717785003301 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 717785003302 putative valine binding site [chemical binding]; other site 717785003303 dimer interface [polypeptide binding]; other site 717785003304 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 717785003305 LysE type translocator; Region: LysE; cl00565 717785003306 ketol-acid reductoisomerase; Provisional; Region: PRK05479 717785003307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003308 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 717785003309 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 717785003310 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785003311 N-terminal plug; other site 717785003312 ligand-binding site [chemical binding]; other site 717785003313 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 717785003314 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 717785003315 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785003316 2-isopropylmalate synthase; Validated; Region: PRK00915 717785003317 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 717785003318 active site 717785003319 catalytic residues [active] 717785003320 metal binding site [ion binding]; metal-binding site 717785003321 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 717785003322 rod shape-determining protein MreB; Provisional; Region: PRK13930 717785003323 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 717785003324 ATP binding site [chemical binding]; other site 717785003325 profilin binding site; other site 717785003326 rod shape-determining protein MreC; Provisional; Region: PRK13922 717785003327 rod shape-determining protein MreC; Region: MreC; pfam04085 717785003328 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 717785003329 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 717785003330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785003331 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 717785003332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785003333 active site 717785003334 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 717785003335 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 717785003336 active site 717785003337 nucleotide-binding site [chemical binding]; other site 717785003338 metal-binding site [ion binding] 717785003339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785003340 active site 717785003341 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 717785003342 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 717785003343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785003344 DNA-binding site [nucleotide binding]; DNA binding site 717785003345 RNA-binding motif; other site 717785003346 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 717785003347 Predicted deacylase [General function prediction only]; Region: COG3608 717785003348 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 717785003349 active site 717785003350 Zn-binding site [ion binding]; other site 717785003351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003352 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785003353 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785003354 Trp docking motif; other site 717785003355 active site 717785003356 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785003357 ethanolamine permease; Region: 2A0305; TIGR00908 717785003358 response regulator FixJ; Provisional; Region: fixJ; PRK09390 717785003359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003360 active site 717785003361 phosphorylation site [posttranslational modification] 717785003362 intermolecular recognition site; other site 717785003363 dimerization interface [polypeptide binding]; other site 717785003364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785003365 DNA binding residues [nucleotide binding] 717785003366 dimerization interface [polypeptide binding]; other site 717785003367 MASE1; Region: MASE1; pfam05231 717785003368 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 717785003369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 717785003370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785003371 dimer interface [polypeptide binding]; other site 717785003372 phosphorylation site [posttranslational modification] 717785003373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003374 ATP binding site [chemical binding]; other site 717785003375 Mg2+ binding site [ion binding]; other site 717785003376 G-X-G motif; other site 717785003377 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785003378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003379 NodT family; Region: outer_NodT; TIGR01845 717785003380 Outer membrane efflux protein; Region: OEP; pfam02321 717785003381 Outer membrane efflux protein; Region: OEP; pfam02321 717785003382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003383 binding surface 717785003384 TPR motif; other site 717785003385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003386 binding surface 717785003387 TPR motif; other site 717785003388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003389 TPR motif; other site 717785003390 binding surface 717785003391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003392 binding surface 717785003393 TPR motif; other site 717785003394 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 717785003395 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 717785003396 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 717785003397 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 717785003398 NADP binding site [chemical binding]; other site 717785003399 active site 717785003400 putative substrate binding site [chemical binding]; other site 717785003401 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 717785003402 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 717785003403 NADP-binding site; other site 717785003404 homotetramer interface [polypeptide binding]; other site 717785003405 substrate binding site [chemical binding]; other site 717785003406 homodimer interface [polypeptide binding]; other site 717785003407 active site 717785003408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003409 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785003410 putative substrate translocation pore; other site 717785003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003412 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785003413 Protein of unknown function (DUF745); Region: DUF745; pfam05335 717785003414 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 717785003415 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785003416 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 717785003417 CrcB-like protein; Region: CRCB; cl09114 717785003418 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785003419 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 717785003420 putative [4Fe-4S] binding site [ion binding]; other site 717785003421 putative molybdopterin cofactor binding site [chemical binding]; other site 717785003422 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 717785003423 molybdopterin cofactor binding site; other site 717785003424 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 717785003425 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 717785003426 DXD motif; other site 717785003427 cellulose synthase A [UDP-forming], catalytic subunit; Region: PLN02915 717785003428 PilZ domain; Region: PilZ; cl01260 717785003429 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785003430 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 717785003431 Arginase family; Region: Arginase; cl00306 717785003432 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785003433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785003434 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785003435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785003437 dimerization interface [polypeptide binding]; other site 717785003438 UreD urease accessory protein; Region: UreD; cl00530 717785003439 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 717785003440 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 717785003441 alpha-gamma subunit interface [polypeptide binding]; other site 717785003442 beta-gamma subunit interface [polypeptide binding]; other site 717785003443 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 717785003444 gamma-beta subunit interface [polypeptide binding]; other site 717785003445 alpha-beta subunit interface [polypeptide binding]; other site 717785003446 urease subunit alpha; Reviewed; Region: ureC; PRK13207 717785003447 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 717785003448 subunit interactions [polypeptide binding]; other site 717785003449 active site 717785003450 flap region; other site 717785003451 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 717785003452 dimer interface [polypeptide binding]; other site 717785003453 catalytic residues [active] 717785003454 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 717785003455 UreF; Region: UreF; pfam01730 717785003456 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785003457 High-affinity nickel-transport protein; Region: NicO; cl00964 717785003458 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003460 active site 717785003461 phosphorylation site [posttranslational modification] 717785003462 intermolecular recognition site; other site 717785003463 dimerization interface [polypeptide binding]; other site 717785003464 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785003465 DNA binding residues [nucleotide binding] 717785003466 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 717785003467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785003468 dimer interface [polypeptide binding]; other site 717785003469 phosphorylation site [posttranslational modification] 717785003470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003471 ATP binding site [chemical binding]; other site 717785003472 Mg2+ binding site [ion binding]; other site 717785003473 G-X-G motif; other site 717785003474 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003476 active site 717785003477 phosphorylation site [posttranslational modification] 717785003478 intermolecular recognition site; other site 717785003479 dimerization interface [polypeptide binding]; other site 717785003480 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 717785003481 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 717785003482 putative ligand binding site [chemical binding]; other site 717785003483 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785003484 TM-ABC transporter signature motif; other site 717785003485 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785003486 TM-ABC transporter signature motif; other site 717785003487 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 717785003488 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 717785003489 Walker A/P-loop; other site 717785003490 ATP binding site [chemical binding]; other site 717785003491 Q-loop/lid; other site 717785003492 ABC transporter signature motif; other site 717785003493 Walker B; other site 717785003494 D-loop; other site 717785003495 H-loop/switch region; other site 717785003496 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 717785003497 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 717785003498 Walker A/P-loop; other site 717785003499 ATP binding site [chemical binding]; other site 717785003500 Q-loop/lid; other site 717785003501 ABC transporter signature motif; other site 717785003502 Walker B; other site 717785003503 D-loop; other site 717785003504 H-loop/switch region; other site 717785003505 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 717785003506 haloalkane dehalogenase; Provisional; Region: PRK03592 717785003507 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 717785003508 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 717785003509 putative heme binding pocket [chemical binding]; other site 717785003510 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785003511 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 717785003512 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 717785003513 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785003514 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 717785003515 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 717785003516 folate binding site [chemical binding]; other site 717785003517 NADP+ binding site [chemical binding]; other site 717785003518 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 717785003519 NAD(P) binding site [chemical binding]; other site 717785003520 catalytic residues [active] 717785003521 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003523 active site 717785003524 phosphorylation site [posttranslational modification] 717785003525 intermolecular recognition site; other site 717785003526 dimerization interface [polypeptide binding]; other site 717785003527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785003528 dimer interface [polypeptide binding]; other site 717785003529 phosphorylation site [posttranslational modification] 717785003530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003531 ATP binding site [chemical binding]; other site 717785003532 Mg2+ binding site [ion binding]; other site 717785003533 G-X-G motif; other site 717785003534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003535 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003536 active site 717785003537 phosphorylation site [posttranslational modification] 717785003538 intermolecular recognition site; other site 717785003539 dimerization interface [polypeptide binding]; other site 717785003540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785003541 dimer interface [polypeptide binding]; other site 717785003542 phosphorylation site [posttranslational modification] 717785003543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003544 ATP binding site [chemical binding]; other site 717785003545 G-X-G motif; other site 717785003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785003547 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003549 active site 717785003550 phosphorylation site [posttranslational modification] 717785003551 intermolecular recognition site; other site 717785003552 dimerization interface [polypeptide binding]; other site 717785003553 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785003554 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785003555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785003556 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785003557 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 717785003558 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 717785003559 Walker A/P-loop; other site 717785003560 ATP binding site [chemical binding]; other site 717785003561 Q-loop/lid; other site 717785003562 ABC transporter signature motif; other site 717785003563 Walker B; other site 717785003564 D-loop; other site 717785003565 H-loop/switch region; other site 717785003566 TOBE domain; Region: TOBE_2; cl01440 717785003567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785003568 dimer interface [polypeptide binding]; other site 717785003569 conserved gate region; other site 717785003570 putative PBP binding loops; other site 717785003571 ABC-ATPase subunit interface; other site 717785003572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785003573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785003574 dimer interface [polypeptide binding]; other site 717785003575 conserved gate region; other site 717785003576 putative PBP binding loops; other site 717785003577 ABC-ATPase subunit interface; other site 717785003578 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785003579 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785003580 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 717785003581 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 717785003582 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 717785003583 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785003584 putative [4Fe-4S] binding site [ion binding]; other site 717785003585 putative molybdopterin cofactor binding site [chemical binding]; other site 717785003586 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 717785003587 putative molybdopterin cofactor binding site; other site 717785003588 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 717785003589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785003590 FeS/SAM binding site; other site 717785003591 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 717785003592 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 717785003593 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 717785003594 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785003595 motif 1; other site 717785003596 dimer interface [polypeptide binding]; other site 717785003597 active site 717785003598 motif 2; other site 717785003599 motif 3; other site 717785003600 elongation factor P; Validated; Region: PRK00529 717785003601 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 717785003602 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 717785003603 RNA binding site [nucleotide binding]; other site 717785003604 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 717785003605 RNA binding site [nucleotide binding]; other site 717785003606 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785003607 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785003608 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 717785003609 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 717785003610 dimer interface [polypeptide binding]; other site 717785003611 putative functional site; other site 717785003612 putative MPT binding site; other site 717785003613 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 717785003614 trimer interface [polypeptide binding]; other site 717785003615 dimer interface [polypeptide binding]; other site 717785003616 putative active site [active] 717785003617 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 717785003618 active site 717785003619 ribulose/triose binding site [chemical binding]; other site 717785003620 phosphate binding site [ion binding]; other site 717785003621 substrate (anthranilate) binding pocket [chemical binding]; other site 717785003622 product (indole) binding pocket [chemical binding]; other site 717785003623 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 717785003624 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 717785003625 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 717785003626 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 717785003627 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 717785003628 glutamine binding [chemical binding]; other site 717785003629 catalytic triad [active] 717785003630 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785003631 catalytic core [active] 717785003632 anthranilate synthase component I; Provisional; Region: PRK13573 717785003633 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 717785003634 chorismate binding enzyme; Region: Chorismate_bind; cl10555 717785003635 periplasmic folding chaperone; Provisional; Region: PRK10788 717785003636 PPIC-type PPIASE domain; Region: Rotamase; cl08278 717785003637 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 717785003638 substrate binding site [chemical binding]; other site 717785003639 dimer interface [polypeptide binding]; other site 717785003640 catalytic triad [active] 717785003641 CTP synthetase; Validated; Region: pyrG; PRK05380 717785003642 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 717785003643 Catalytic site [active] 717785003644 Active site [active] 717785003645 UTP binding site [chemical binding]; other site 717785003646 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 717785003647 active site 717785003648 putative oxyanion hole; other site 717785003649 catalytic triad [active] 717785003650 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 717785003651 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 717785003652 NeuB family; Region: NeuB; cl00496 717785003653 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785003654 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 717785003655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785003656 Walker A/P-loop; other site 717785003657 ATP binding site [chemical binding]; other site 717785003658 Q-loop/lid; other site 717785003659 ABC transporter signature motif; other site 717785003660 Walker B; other site 717785003661 D-loop; other site 717785003662 H-loop/switch region; other site 717785003663 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 717785003664 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 717785003665 structural tetrad; other site 717785003666 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785003667 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785003668 ligand binding site [chemical binding]; other site 717785003669 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 717785003670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785003671 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785003672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785003673 dimer interface [polypeptide binding]; other site 717785003674 conserved gate region; other site 717785003675 putative PBP binding loops; other site 717785003676 ABC-ATPase subunit interface; other site 717785003677 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785003678 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785003679 Walker A/P-loop; other site 717785003680 ATP binding site [chemical binding]; other site 717785003681 Q-loop/lid; other site 717785003682 ABC transporter signature motif; other site 717785003683 Walker B; other site 717785003684 D-loop; other site 717785003685 H-loop/switch region; other site 717785003686 Protein of unknown function (DUF556); Region: DUF556; cl00822 717785003687 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 717785003688 active site 717785003689 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 717785003690 nucleotide binding site [chemical binding]; other site 717785003691 substrate binding site [chemical binding]; other site 717785003692 Protein of unknown function (DUF447); Region: DUF447; cl01035 717785003693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785003694 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 717785003695 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 717785003696 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 717785003697 active site 717785003698 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 717785003699 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 717785003700 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 717785003701 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785003702 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5)...; Region: MCH; cd00545 717785003703 trimer interface I [polypeptide binding]; other site 717785003704 putative substrate binding pocket [chemical binding]; other site 717785003705 trimer interface II [polypeptide binding]; other site 717785003706 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 717785003707 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785003708 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 717785003709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003710 NAD(P) binding pocket [chemical binding]; other site 717785003711 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 717785003712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 717785003713 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 717785003714 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 717785003715 aromatic arch; other site 717785003716 DCoH dimer interaction site [polypeptide binding]; other site 717785003717 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 717785003718 DCoH tetramer interaction site [polypeptide binding]; other site 717785003719 substrate binding site [chemical binding]; other site 717785003720 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 717785003721 catalytic center binding site [active] 717785003722 ATP binding site [chemical binding]; other site 717785003723 Cytochrome c; Region: Cytochrom_C; cl11414 717785003724 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 717785003725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785003726 FeS/SAM binding site; other site 717785003727 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 717785003728 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 717785003729 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 717785003730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785003731 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 717785003732 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 717785003733 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785003734 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 717785003735 FAD binding pocket [chemical binding]; other site 717785003736 FAD binding motif [chemical binding]; other site 717785003737 catalytic residues [active] 717785003738 NAD binding pocket [chemical binding]; other site 717785003739 phosphate binding motif [ion binding]; other site 717785003740 beta-alpha-beta structure motif; other site 717785003741 sulfite reductase subunit beta; Provisional; Region: PRK13504 717785003742 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785003743 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785003744 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 717785003745 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 717785003746 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 717785003747 G1 box; other site 717785003748 putative GEF interaction site [polypeptide binding]; other site 717785003749 GTP/Mg2+ binding site [chemical binding]; other site 717785003750 Switch I region; other site 717785003751 G2 box; other site 717785003752 CysD dimerization site [polypeptide binding]; other site 717785003753 G3 box; other site 717785003754 Switch II region; other site 717785003755 G4 box; other site 717785003756 G5 box; other site 717785003757 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 717785003758 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-...; Region: Translation_factor_III; cl02786 717785003759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785003760 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 717785003761 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 717785003762 Active Sites [active] 717785003763 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 717785003764 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 717785003765 Active Sites [active] 717785003766 Predicted flavoproteins [General function prediction only]; Region: COG2081 717785003767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785003768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785003769 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 717785003770 dimer interface [polypeptide binding]; other site 717785003771 active site 717785003772 metal binding site [ion binding]; metal-binding site 717785003773 glutathione binding site [chemical binding]; other site 717785003774 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785003775 DNA-binding site [nucleotide binding]; DNA binding site 717785003776 RNA-binding motif; other site 717785003777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785003778 DNA-binding site [nucleotide binding]; DNA binding site 717785003779 RNA-binding motif; other site 717785003780 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 717785003781 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 717785003782 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 717785003783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785003784 Domain of unknown function (DUF427); Region: DUF427; cl00998 717785003785 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 717785003786 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003787 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785003788 Protein export membrane protein; Region: SecD_SecF; cl14618 717785003789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785003790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785003791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785003793 dimerization interface [polypeptide binding]; other site 717785003794 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785003795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785003796 substrate binding pocket [chemical binding]; other site 717785003797 membrane-bound complex binding site; other site 717785003798 hinge residues; other site 717785003799 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 717785003800 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 717785003801 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 717785003802 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 717785003803 TPP-binding site [chemical binding]; other site 717785003804 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 717785003805 PYR/PP interface [polypeptide binding]; other site 717785003806 tetramer interface [polypeptide binding]; other site 717785003807 dimer interface [polypeptide binding]; other site 717785003808 TPP binding site [chemical binding]; other site 717785003809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785003810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003811 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785003812 putative effector binding pocket; other site 717785003813 dimerization interface [polypeptide binding]; other site 717785003814 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 717785003815 NmrA-like family; Region: NmrA; pfam05368 717785003816 putative NADP binding site [chemical binding]; other site 717785003817 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 717785003818 active site 717785003819 metal binding site [ion binding]; metal-binding site 717785003820 TIGR03440 family protein; Region: unchr_TIGR03440 717785003821 DinB superfamily; Region: DinB_2; cl00986 717785003822 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 717785003823 probable methyltransferase; Region: TIGR03438 717785003824 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 717785003825 Response regulator receiver domain; Region: Response_reg; pfam00072 717785003826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003827 active site 717785003828 phosphorylation site [posttranslational modification] 717785003829 intermolecular recognition site; other site 717785003830 dimerization interface [polypeptide binding]; other site 717785003831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003832 active site 717785003833 phosphorylation site [posttranslational modification] 717785003834 intermolecular recognition site; other site 717785003835 dimerization interface [polypeptide binding]; other site 717785003836 Protein of unknown function (DUF461); Region: DUF461; cl01071 717785003837 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 717785003838 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 717785003839 Cytochrome c; Region: Cytochrom_C; cl11414 717785003840 Cytochrome c; Region: Cytochrom_C; cl11414 717785003841 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785003842 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785003843 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785003844 Protein of unknown function (DUF962); Region: DUF962; cl01879 717785003845 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785003846 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 717785003847 putative dimer interface [polypeptide binding]; other site 717785003848 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 717785003849 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 717785003850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785003851 cofactor binding site; other site 717785003852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785003853 Transposase domain (DUF772); Region: DUF772; cl12084 717785003854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785003855 DNA binding site [nucleotide binding] 717785003856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785003857 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 717785003858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 717785003859 putative substrate translocation pore; other site 717785003860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785003861 EamA-like transporter family; Region: EamA; cl01037 717785003862 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785003863 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 717785003864 potential catalytic triad [active] 717785003865 conserved cys residue [active] 717785003866 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 717785003867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 717785003868 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785003869 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785003870 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785003871 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785003872 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 717785003873 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 717785003874 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717785003875 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 717785003876 metal-binding site [ion binding] 717785003877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785003878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785003879 FixH; Region: FixH; cl01254 717785003880 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 717785003881 4Fe-4S binding domain; Region: Fer4_5; pfam12801 717785003882 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 717785003883 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 717785003884 Cytochrome c; Region: Cytochrom_C; cl11414 717785003885 Cytochrome c; Region: Cytochrom_C; cl11414 717785003886 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 717785003887 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 717785003888 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 717785003889 Low-spin heme binding site [chemical binding]; other site 717785003890 Putative water exit pathway; other site 717785003891 Binuclear center (active site) [active] 717785003892 Putative proton exit pathway; other site 717785003893 Membrane transport protein; Region: Mem_trans; cl09117 717785003894 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 717785003895 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785003896 ligand binding site [chemical binding]; other site 717785003897 flexible hinge region; other site 717785003898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785003899 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785003900 Sulfatase; Region: Sulfatase; cl10460 717785003901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785003902 motif II; other site 717785003903 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 717785003904 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 717785003905 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785003906 Protein of unknown function (DUF745); Region: DUF745; pfam05335 717785003907 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; cl10556 717785003908 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 717785003909 Cytochrome c552; Region: Cytochrom_C552; pfam02335 717785003910 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 717785003911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003912 binding surface 717785003913 TPR motif; other site 717785003914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003915 TPR motif; other site 717785003916 binding surface 717785003917 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785003918 Sulfatase; Region: Sulfatase; cl10460 717785003919 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785003920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785003921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785003922 SET domain; Region: SET; cl02566 717785003923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785003924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785003925 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785003926 nucleophile elbow; other site 717785003927 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003928 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785003929 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 717785003930 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 717785003931 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 717785003932 FAD binding pocket [chemical binding]; other site 717785003933 FAD binding motif [chemical binding]; other site 717785003934 phosphate binding motif [ion binding]; other site 717785003935 beta-alpha-beta structure motif; other site 717785003936 NAD binding pocket [chemical binding]; other site 717785003937 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 717785003938 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 717785003939 K+-transporting ATPase, c chain; Region: KdpC; cl00944 717785003940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785003941 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785003943 active site 717785003944 phosphorylation site [posttranslational modification] 717785003945 intermolecular recognition site; other site 717785003946 dimerization interface [polypeptide binding]; other site 717785003947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785003948 DNA binding site [nucleotide binding] 717785003949 sensor protein PhoQ; Provisional; Region: PRK10815 717785003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785003951 ATP binding site [chemical binding]; other site 717785003952 Mg2+ binding site [ion binding]; other site 717785003953 G-X-G motif; other site 717785003954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785003955 DNA binding site [nucleotide binding] 717785003956 Predicted integral membrane protein [Function unknown]; Region: COG5616 717785003957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003958 binding surface 717785003959 TPR motif; other site 717785003960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785003961 binding surface 717785003962 TPR motif; other site 717785003963 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 717785003964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785003965 NAD(P) binding site [chemical binding]; other site 717785003966 active site 717785003967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785003968 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 717785003969 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 717785003970 Substrate binding site [chemical binding]; other site 717785003971 Cupin domain; Region: Cupin_2; cl09118 717785003972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785003973 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 717785003974 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 717785003975 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785003976 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785003977 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 717785003978 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785003979 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 717785003980 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785003981 Bacterial sugar transferase; Region: Bac_transf; cl00939 717785003982 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785003983 SLBB domain; Region: SLBB; pfam10531 717785003984 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 717785003985 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785003986 Chain length determinant protein; Region: Wzz; cl01623 717785003987 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 717785003988 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785003989 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 717785003990 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 717785003991 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785003992 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 717785003993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785003994 N-terminal plug; other site 717785003995 ligand-binding site [chemical binding]; other site 717785003996 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785003997 Protein of unknown function, DUF417; Region: DUF417; cl01162 717785003998 Cupin domain; Region: Cupin_2; cl09118 717785003999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785004001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004002 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 717785004003 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme 717785004004 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 717785004005 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme 717785004006 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785004007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 717785004008 dimer interface [polypeptide binding]; other site 717785004009 phosphorylation site [posttranslational modification] 717785004010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004011 ATP binding site [chemical binding]; other site 717785004012 G-X-G motif; other site 717785004013 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004015 active site 717785004016 phosphorylation site [posttranslational modification] 717785004017 intermolecular recognition site; other site 717785004018 dimerization interface [polypeptide binding]; other site 717785004019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785004020 DNA binding site [nucleotide binding] 717785004021 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 717785004022 Outer membrane efflux protein; Region: OEP; pfam02321 717785004023 Outer membrane efflux protein; Region: OEP; pfam02321 717785004024 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 717785004025 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785004026 NodT family; Region: outer_NodT; TIGR01845 717785004027 Outer membrane efflux protein; Region: OEP; pfam02321 717785004028 Outer membrane efflux protein; Region: OEP; pfam02321 717785004029 macrolide transporter subunit MacA; Provisional; Region: PRK11578 717785004030 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 717785004031 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785004032 Walker A/P-loop; other site 717785004033 ATP binding site [chemical binding]; other site 717785004034 Q-loop/lid; other site 717785004035 ABC transporter signature motif; other site 717785004036 Walker B; other site 717785004037 D-loop; other site 717785004038 H-loop/switch region; other site 717785004039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785004040 FtsX-like permease family; Region: FtsX; pfam02687 717785004041 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004042 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 717785004043 Transposase domain (DUF772); Region: DUF772; cl12084 717785004044 Uncharacterized conserved protein [Function unknown]; Region: COG1432 717785004045 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 717785004046 putative metal binding site [ion binding]; other site 717785004047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004048 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785004049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004050 ATP binding site [chemical binding]; other site 717785004051 Mg2+ binding site [ion binding]; other site 717785004052 G-X-G motif; other site 717785004053 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785004054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004055 active site 717785004056 phosphorylation site [posttranslational modification] 717785004057 intermolecular recognition site; other site 717785004058 dimerization interface [polypeptide binding]; other site 717785004059 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785004060 DNA binding site [nucleotide binding] 717785004061 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 717785004062 putative active site [active] 717785004063 Transposase domain (DUF772); Region: DUF772; cl12084 717785004064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 717785004065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004066 Active site [active] 717785004067 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785004068 putative metal binding site [ion binding]; other site 717785004069 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 717785004070 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 717785004071 substrate binding site [chemical binding]; other site 717785004072 tetramer interface [polypeptide binding]; other site 717785004073 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 717785004074 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 717785004075 NADP binding site [chemical binding]; other site 717785004076 active site 717785004077 putative substrate binding site [chemical binding]; other site 717785004078 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 717785004079 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 717785004080 NAD binding site [chemical binding]; other site 717785004081 substrate binding site [chemical binding]; other site 717785004082 homodimer interface [polypeptide binding]; other site 717785004083 active site 717785004084 Cupin domain; Region: Cupin_2; cl09118 717785004085 Cupin domain; Region: Cupin_2; cl09118 717785004086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785004087 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785004088 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004089 Walker A/P-loop; other site 717785004090 ATP binding site [chemical binding]; other site 717785004091 Q-loop/lid; other site 717785004092 ABC transporter signature motif; other site 717785004093 Walker B; other site 717785004094 D-loop; other site 717785004095 H-loop/switch region; other site 717785004096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785004097 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 717785004098 sulfotransferase; Region: PLN02164 717785004099 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 717785004100 substrate binding site [chemical binding]; other site 717785004101 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 717785004102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004103 NAD(P) binding site [chemical binding]; other site 717785004104 active site 717785004105 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 717785004106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785004107 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 717785004108 Cupin domain; Region: Cupin_2; cl09118 717785004109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785004110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004111 NAD(P) binding site [chemical binding]; other site 717785004112 active site 717785004113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004114 active site 717785004115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004116 active site 717785004117 probable pectinesterase/pectinesterase inhibitor; Region: PLN02484 717785004118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785004119 active site 717785004120 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785004121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004122 active site 717785004123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004124 active site 717785004125 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 717785004126 Radical SAM; Region: Elp3; smart00729 717785004127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 717785004128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004129 non-specific DNA binding site [nucleotide binding]; other site 717785004130 salt bridge; other site 717785004131 sequence-specific DNA binding site [nucleotide binding]; other site 717785004132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004133 non-specific DNA binding site [nucleotide binding]; other site 717785004134 salt bridge; other site 717785004135 sequence-specific DNA binding site [nucleotide binding]; other site 717785004136 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 717785004137 Protein of unknown function (DUF968); Region: DUF968; pfam06147 717785004138 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 717785004139 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785004140 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785004141 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 717785004142 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 717785004143 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785004144 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785004145 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785004146 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 717785004147 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 717785004148 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 717785004149 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785004150 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 717785004151 putative active site [active] 717785004152 putative FMN binding site [chemical binding]; other site 717785004153 putative substrate binding site [chemical binding]; other site 717785004154 putative catalytic residue [active] 717785004155 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 717785004156 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 717785004157 Cysteine-rich domain; Region: CCG; pfam02754 717785004158 Cysteine-rich domain; Region: CCG; pfam02754 717785004159 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 717785004160 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 717785004161 Ligand binding site [chemical binding]; other site 717785004162 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785004163 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 717785004164 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785004165 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785004166 [2Fe-2S] cluster binding site [ion binding]; other site 717785004167 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 717785004168 putative alpha subunit interface [polypeptide binding]; other site 717785004169 putative active site [active] 717785004170 putative substrate binding site [chemical binding]; other site 717785004171 Fe binding site [ion binding]; other site 717785004172 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785004173 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 717785004174 FAD binding pocket [chemical binding]; other site 717785004175 FAD binding motif [chemical binding]; other site 717785004176 phosphate binding motif [ion binding]; other site 717785004177 beta-alpha-beta structure motif; other site 717785004178 NAD binding pocket [chemical binding]; other site 717785004179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785004180 catalytic loop [active] 717785004181 iron binding site [ion binding]; other site 717785004182 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 717785004183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004184 Walker A/P-loop; other site 717785004185 ATP binding site [chemical binding]; other site 717785004186 Q-loop/lid; other site 717785004187 ABC transporter signature motif; other site 717785004188 Walker B; other site 717785004189 D-loop; other site 717785004190 H-loop/switch region; other site 717785004191 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 717785004192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785004193 dimer interface [polypeptide binding]; other site 717785004194 conserved gate region; other site 717785004195 putative PBP binding loops; other site 717785004196 ABC-ATPase subunit interface; other site 717785004197 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 717785004198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785004199 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785004200 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 717785004201 conserved cys residue [active] 717785004202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785004203 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785004204 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 717785004205 tetrameric interface [polypeptide binding]; other site 717785004206 NAD binding site [chemical binding]; other site 717785004207 catalytic residues [active] 717785004208 choline dehydrogenase; Validated; Region: PRK02106 717785004209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004210 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785004211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004213 putative substrate translocation pore; other site 717785004214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004215 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785004216 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785004217 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785004218 hypothetical protein; Provisional; Region: PRK12472 717785004219 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785004220 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 717785004221 Bacterial sugar transferase; Region: Bac_transf; cl00939 717785004222 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785004223 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 717785004224 domain_subunit interface; other site 717785004225 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 717785004226 lobe; Region: FTR; pfam01913 717785004227 FTR, proximal lobe; Region: FTR_C; pfam02741 717785004228 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 717785004229 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 717785004230 active site 717785004231 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 717785004232 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 717785004233 putative [4Fe-4S] binding site [ion binding]; other site 717785004234 putative molybdopterin cofactor binding site [chemical binding]; other site 717785004235 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785004236 putative hydrophobic ligand binding site [chemical binding]; other site 717785004237 protein interface [polypeptide binding]; other site 717785004238 gate; other site 717785004239 Uncharacterized conserved protein [Function unknown]; Region: COG3391 717785004240 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004241 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004242 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 717785004243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785004244 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785004245 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785004246 Trp docking motif; other site 717785004247 'Velcro' closure; other site 717785004248 active site 717785004249 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 717785004250 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717785004251 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785004252 substrate binding pocket [chemical binding]; other site 717785004253 membrane-bound complex binding site; other site 717785004254 hinge residues; other site 717785004255 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 717785004256 active site residue [active] 717785004257 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 717785004258 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 717785004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004260 transketolase; Reviewed; Region: PRK05899 717785004261 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 717785004262 TPP-binding site [chemical binding]; other site 717785004263 dimer interface [polypeptide binding]; other site 717785004264 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785004265 PYR/PP interface [polypeptide binding]; other site 717785004266 dimer interface [polypeptide binding]; other site 717785004267 TPP binding site [chemical binding]; other site 717785004268 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785004269 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 717785004270 substrate binding site [chemical binding]; other site 717785004271 hinge regions; other site 717785004272 ADP binding site [chemical binding]; other site 717785004273 catalytic site [active] 717785004274 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 717785004275 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 717785004276 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 717785004277 dimer interface [polypeptide binding]; other site 717785004278 substrate binding site [chemical binding]; other site 717785004279 ATP binding site [chemical binding]; other site 717785004280 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 717785004281 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 717785004282 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 717785004283 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 717785004284 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 717785004285 active site 717785004286 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 717785004287 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785004288 putative binding surface; other site 717785004289 active site 717785004290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785004291 catalytic loop [active] 717785004292 iron binding site [ion binding]; other site 717785004293 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 717785004294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004296 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785004297 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785004298 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785004299 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 717785004300 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 717785004301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785004302 active site 717785004303 hypothetical protein; Provisional; Region: PRK05415 717785004304 Domain of unknown function (DUF697); Region: DUF697; cl12064 717785004305 YcjX-like family, DUF463; Region: DUF463; cl01193 717785004306 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 717785004307 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 717785004308 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 717785004309 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 717785004310 Substrate binding site [chemical binding]; other site 717785004311 Mg++ binding site [ion binding]; other site 717785004312 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 717785004313 active site 717785004314 substrate binding site [chemical binding]; other site 717785004315 CoA binding site [chemical binding]; other site 717785004316 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 717785004317 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 717785004318 glutaminase active site [active] 717785004319 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 717785004320 dimer interface [polypeptide binding]; other site 717785004321 active site 717785004322 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 717785004323 dimer interface [polypeptide binding]; other site 717785004324 active site 717785004325 Sporulation related domain; Region: SPOR; cl10051 717785004326 Protein of unknown function (DUF502); Region: DUF502; cl01107 717785004327 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 717785004328 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 717785004329 generic binding surface II; other site 717785004330 ssDNA binding site; other site 717785004331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785004332 ATP binding site [chemical binding]; other site 717785004333 putative Mg++ binding site [ion binding]; other site 717785004334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785004335 nucleotide binding region [chemical binding]; other site 717785004336 ATP-binding site [chemical binding]; other site 717785004337 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 717785004338 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 717785004339 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 717785004340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785004341 ATP binding site [chemical binding]; other site 717785004342 putative Mg++ binding site [ion binding]; other site 717785004343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785004344 nucleotide binding region [chemical binding]; other site 717785004345 ATP-binding site [chemical binding]; other site 717785004346 TRCF domain; Region: TRCF; pfam03461 717785004347 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 717785004348 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785004349 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 717785004350 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 717785004351 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785004352 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 717785004353 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785004354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785004355 Coenzyme A binding pocket [chemical binding]; other site 717785004356 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 717785004357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785004358 active site 717785004359 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 717785004360 Protein of unknown function, DUF486; Region: DUF486; cl01236 717785004361 Arginase family; Region: Arginase; cl00306 717785004362 Putative ParB-like nuclease; Region: ParBc_2; cl01772 717785004363 Protein of unknown function (DUF992); Region: DUF992; pfam06186 717785004364 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 717785004365 Protein of unknown function, DUF393; Region: DUF393; cl01136 717785004366 Pirin-related protein [General function prediction only]; Region: COG1741 717785004367 Cupin domain; Region: Cupin_2; cl09118 717785004368 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 717785004369 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 717785004370 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 717785004371 active site 717785004372 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 717785004373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 717785004374 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 717785004375 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717785004376 CoenzymeA binding site [chemical binding]; other site 717785004377 subunit interaction site [polypeptide binding]; other site 717785004378 PHB binding site; other site 717785004379 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 717785004380 Ligand Binding Site [chemical binding]; other site 717785004381 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 717785004382 enolase; Provisional; Region: eno; PRK00077 717785004383 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 717785004384 dimer interface [polypeptide binding]; other site 717785004385 metal binding site [ion binding]; metal-binding site 717785004386 substrate binding pocket [chemical binding]; other site 717785004387 short chain dehydrogenase; Provisional; Region: PRK06701 717785004388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004389 NAD(P) binding site [chemical binding]; other site 717785004390 active site 717785004391 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785004392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785004393 P-loop; other site 717785004394 Magnesium ion binding site [ion binding]; other site 717785004395 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785004396 Magnesium ion binding site [ion binding]; other site 717785004397 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 717785004398 catalytic triad [active] 717785004399 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 717785004400 ligand-binding site [chemical binding]; other site 717785004401 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 717785004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004403 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 717785004404 PAS fold; Region: PAS_4; pfam08448 717785004405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785004406 PAS fold; Region: PAS_3; pfam08447 717785004407 putative active site [active] 717785004408 heme pocket [chemical binding]; other site 717785004409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785004410 PAS fold; Region: PAS_3; pfam08447 717785004411 putative active site [active] 717785004412 heme pocket [chemical binding]; other site 717785004413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785004414 metal binding site [ion binding]; metal-binding site 717785004415 active site 717785004416 I-site; other site 717785004417 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 717785004418 active site 717785004419 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785004420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785004421 active site 717785004422 catalytic tetrad [active] 717785004423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785004424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785004425 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785004426 putative effector binding pocket; other site 717785004427 putative dimerization interface [polypeptide binding]; other site 717785004428 Membrane transport protein; Region: Mem_trans; cl09117 717785004429 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785004430 Domain of unknown function DUF20; Region: UPF0118; cl00465 717785004431 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 717785004432 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 717785004433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004435 active site 717785004436 phosphorylation site [posttranslational modification] 717785004437 intermolecular recognition site; other site 717785004438 dimerization interface [polypeptide binding]; other site 717785004439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785004440 DNA binding site [nucleotide binding] 717785004441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004443 ATP binding site [chemical binding]; other site 717785004444 Mg2+ binding site [ion binding]; other site 717785004445 G-X-G motif; other site 717785004446 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004447 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004448 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004449 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 717785004450 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 717785004451 active site 717785004452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785004453 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785004454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785004455 dimer interface [polypeptide binding]; other site 717785004456 phosphorylation site [posttranslational modification] 717785004457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004458 ATP binding site [chemical binding]; other site 717785004459 Mg2+ binding site [ion binding]; other site 717785004460 G-X-G motif; other site 717785004461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785004462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004463 active site 717785004464 phosphorylation site [posttranslational modification] 717785004465 intermolecular recognition site; other site 717785004466 dimerization interface [polypeptide binding]; other site 717785004467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785004468 DNA binding site [nucleotide binding] 717785004469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004470 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785004471 putative substrate translocation pore; other site 717785004472 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 717785004473 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 717785004474 dimer interface [polypeptide binding]; other site 717785004475 ssDNA binding site [nucleotide binding]; other site 717785004476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785004477 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 717785004478 nucleotide binding site [chemical binding]; other site 717785004479 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717785004480 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785004481 Phage integrase family; Region: Phage_integrase; pfam00589 717785004482 active site 717785004483 Int/Topo IB signature motif; other site 717785004484 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785004485 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 717785004486 Sporulation related domain; Region: SPOR; cl10051 717785004487 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 717785004488 Beta-lactamase; Region: Beta-lactamase; cl01009 717785004489 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 717785004490 thymidylate kinase; Validated; Region: tmk; PRK00698 717785004491 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 717785004492 TMP-binding site; other site 717785004493 ATP-binding site [chemical binding]; other site 717785004494 DNA polymerase III subunit delta'; Validated; Region: PRK07471 717785004495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004496 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 717785004497 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 717785004498 active site 717785004499 HIGH motif; other site 717785004500 KMSKS motif; other site 717785004501 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 717785004502 tRNA binding surface [nucleotide binding]; other site 717785004503 anticodon binding site; other site 717785004504 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 717785004505 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 717785004506 active site 717785004507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785004508 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 717785004509 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 717785004510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004511 NAD(P) binding site [chemical binding]; other site 717785004512 active site 717785004513 amidophosphoribosyltransferase; Provisional; Region: PRK09123 717785004514 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 717785004515 active site 717785004516 tetramer interface [polypeptide binding]; other site 717785004517 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785004518 Colicin V production protein; Region: Colicin_V; cl00567 717785004519 DNA repair protein RadA; Provisional; Region: PRK11823 717785004520 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 717785004521 Walker A motif/ATP binding site; other site 717785004522 ATP binding site [chemical binding]; other site 717785004523 Walker B motif; other site 717785004524 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 717785004525 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 717785004526 active site 717785004527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785004528 dimer interface [polypeptide binding]; other site 717785004529 substrate binding site [chemical binding]; other site 717785004530 catalytic residues [active] 717785004531 replicative DNA helicase; Provisional; Region: PRK09165 717785004532 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 717785004533 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 717785004534 Walker A motif; other site 717785004535 ATP binding site [chemical binding]; other site 717785004536 Walker B motif; other site 717785004537 DNA binding loops [nucleotide binding] 717785004538 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 717785004539 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 717785004540 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 717785004541 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 717785004542 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 717785004543 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 717785004544 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 717785004545 putative metal binding site [ion binding]; other site 717785004546 Acyl transferase domain; Region: Acyl_transf_1; cl08282 717785004547 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 717785004548 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 717785004549 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 717785004550 homotetramer interface [polypeptide binding]; other site 717785004551 NAD(P) binding site [chemical binding]; other site 717785004552 homodimer interface [polypeptide binding]; other site 717785004553 active site 717785004554 Phosphopantetheine attachment site; Region: PP-binding; cl09936 717785004555 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 717785004556 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785004557 dimer interface [polypeptide binding]; other site 717785004558 active site 717785004559 YceG-like family; Region: YceG; pfam02618 717785004560 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 717785004561 dimerization interface [polypeptide binding]; other site 717785004562 hypothetical protein; Provisional; Region: PRK11820 717785004563 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 717785004564 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 717785004565 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 717785004566 catalytic site [active] 717785004567 G-X2-G-X-G-K; other site 717785004568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785004569 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 717785004570 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 717785004571 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 717785004572 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 717785004573 SurA N-terminal domain; Region: SurA_N; pfam09312 717785004574 OstA-like protein; Region: OstA; cl00844 717785004575 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 717785004576 Organic solvent tolerance protein; Region: OstA_C; pfam04453 717785004577 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 717785004578 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 717785004579 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 717785004580 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 717785004581 multifunctional aminopeptidase A; Provisional; Region: PRK00913 717785004582 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 717785004583 interface (dimer of trimers) [polypeptide binding]; other site 717785004584 Substrate-binding/catalytic site; other site 717785004585 Zn-binding sites [ion binding]; other site 717785004586 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 717785004587 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 717785004588 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 717785004589 hypothetical protein; Provisional; Region: PRK06185 717785004590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004592 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 717785004593 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 717785004594 G1 box; other site 717785004595 GTP/Mg2+ binding site [chemical binding]; other site 717785004596 Switch I region; other site 717785004597 G2 box; other site 717785004598 G3 box; other site 717785004599 Switch II region; other site 717785004600 G4 box; other site 717785004601 G5 box; other site 717785004602 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 717785004603 Sm1 motif; other site 717785004604 intra - hexamer interaction site; other site 717785004605 inter - hexamer interaction site [polypeptide binding]; other site 717785004606 nucleotide binding pocket [chemical binding]; other site 717785004607 Sm2 motif; other site 717785004608 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 717785004609 homodimer interface [polypeptide binding]; other site 717785004610 substrate-cofactor binding pocket; other site 717785004611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785004612 Aminotransferase class IV; Region: Aminotran_4; pfam01063 717785004613 catalytic residue [active] 717785004614 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 717785004615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004616 active site 717785004617 phosphorylation site [posttranslational modification] 717785004618 intermolecular recognition site; other site 717785004619 dimerization interface [polypeptide binding]; other site 717785004620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785004621 Walker A motif; other site 717785004622 ATP binding site [chemical binding]; other site 717785004623 Walker B motif; other site 717785004624 arginine finger; other site 717785004625 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785004626 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 717785004627 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785004628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 717785004629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785004630 dimer interface [polypeptide binding]; other site 717785004631 phosphorylation site [posttranslational modification] 717785004632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004633 ATP binding site [chemical binding]; other site 717785004634 Mg2+ binding site [ion binding]; other site 717785004635 G-X-G motif; other site 717785004636 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 717785004637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785004638 active site 717785004639 phosphorylation site [posttranslational modification] 717785004640 intermolecular recognition site; other site 717785004641 dimerization interface [polypeptide binding]; other site 717785004642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785004643 Walker A motif; other site 717785004644 ATP binding site [chemical binding]; other site 717785004645 Walker B motif; other site 717785004646 arginine finger; other site 717785004647 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785004648 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785004649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785004650 dimer interface [polypeptide binding]; other site 717785004651 phosphorylation site [posttranslational modification] 717785004652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785004653 ATP binding site [chemical binding]; other site 717785004654 Mg2+ binding site [ion binding]; other site 717785004655 G-X-G motif; other site 717785004656 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 717785004657 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 717785004658 FMN binding site [chemical binding]; other site 717785004659 active site 717785004660 catalytic residues [active] 717785004661 substrate binding site [chemical binding]; other site 717785004662 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 717785004663 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 717785004664 substrate binding site [chemical binding]; other site 717785004665 dimer interface [polypeptide binding]; other site 717785004666 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 717785004667 homotrimer interaction site [polypeptide binding]; other site 717785004668 zinc binding site [ion binding]; other site 717785004669 CDP-binding sites; other site 717785004670 Cation efflux family; Region: Cation_efflux; cl00316 717785004671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785004672 Competence-damaged protein; Region: CinA; cl00666 717785004673 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 717785004674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785004675 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785004676 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 717785004677 putative coenzyme Q binding site [chemical binding]; other site 717785004678 Septum formation initiator; Region: DivIC; cl11433 717785004679 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785004680 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 717785004681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785004683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 717785004684 putative acyl-acceptor binding pocket; other site 717785004685 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 717785004686 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 717785004687 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 717785004688 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 717785004689 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 717785004690 active site 717785004691 dimer interface [polypeptide binding]; other site 717785004692 motif 1; other site 717785004693 motif 2; other site 717785004694 motif 3; other site 717785004695 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 717785004696 anticodon binding site; other site 717785004697 Domain of unknown function DUF37; Region: DUF37; cl00506 717785004698 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717785004699 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 717785004700 trimerization site [polypeptide binding]; other site 717785004701 active site 717785004702 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 717785004703 hypothetical protein; Provisional; Region: PRK10279 717785004704 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785004705 nucleophile elbow; other site 717785004706 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 717785004707 FOG: CBS domain [General function prediction only]; Region: COG0517 717785004708 Rhomboid family; Region: Rhomboid; cl11446 717785004709 PAS domain; Region: PAS_5; cl11565 717785004710 PilZ domain; Region: PilZ; cl01260 717785004711 PilZ domain; Region: PilZ; cl01260 717785004712 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479 717785004713 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 717785004714 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 717785004715 trimer interface [polypeptide binding]; other site 717785004716 putative metal binding site [ion binding]; other site 717785004717 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 717785004718 serine acetyltransferase; Provisional; Region: cysE; PRK11132 717785004719 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 717785004720 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 717785004721 trimer interface [polypeptide binding]; other site 717785004722 active site 717785004723 substrate binding site [chemical binding]; other site 717785004724 CoA binding site [chemical binding]; other site 717785004725 enoyl-CoA hydratase; Provisional; Region: PRK06127 717785004726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785004727 substrate binding site [chemical binding]; other site 717785004728 oxyanion hole (OAH) forming residues; other site 717785004729 trimer interface [polypeptide binding]; other site 717785004730 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785004731 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 717785004732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785004733 Coenzyme A binding pocket [chemical binding]; other site 717785004734 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7992050; Product type e : enzyme 717785004735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785004736 S-adenosylmethionine binding site [chemical binding]; other site 717785004737 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 717785004738 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 717785004739 FAD binding site [chemical binding]; other site 717785004740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785004741 putative DNA binding site [nucleotide binding]; other site 717785004742 putative Zn2+ binding site [ion binding]; other site 717785004743 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 717785004744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785004745 S-adenosylmethionine binding site [chemical binding]; other site 717785004746 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 717785004747 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 717785004748 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785004749 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 717785004750 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785004751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785004752 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785004753 ABC transporter; Region: ABC_tran_2; pfam12848 717785004754 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785004755 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 717785004756 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 717785004757 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 717785004758 Protein of unknown function (DUF1022); Region: DUF1022; pfam06258 717785004759 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785004760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785004761 dimerization interface [polypeptide binding]; other site 717785004762 putative DNA binding site [nucleotide binding]; other site 717785004763 putative Zn2+ binding site [ion binding]; other site 717785004764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785004765 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 717785004766 domain; Region: GreA_GreB_N; pfam03449 717785004767 C-term; Region: GreA_GreB; pfam01272 717785004768 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 717785004769 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785004770 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785004771 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 717785004772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785004773 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785004774 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 717785004775 IMP binding site; other site 717785004776 dimer interface [polypeptide binding]; other site 717785004777 interdomain contacts; other site 717785004778 partial ornithine binding site; other site 717785004779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785004781 putative substrate translocation pore; other site 717785004782 Protein of unknown function, DUF399; Region: DUF399; cl01139 717785004783 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 717785004784 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 717785004785 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 717785004786 catalytic site [active] 717785004787 subunit interface [polypeptide binding]; other site 717785004788 GatB domain; Region: GatB_Yqey; cl11497 717785004789 DNA primase; Validated; Region: dnaG; PRK05667 717785004790 CHC2 zinc finger; Region: zf-CHC2; cl02597 717785004791 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 717785004792 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 717785004793 active site 717785004794 metal binding site [ion binding]; metal-binding site 717785004795 interdomain interaction site; other site 717785004796 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 717785004797 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 717785004798 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 717785004799 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 717785004800 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 717785004801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785004802 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 717785004803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785004804 DNA binding residues [nucleotide binding] 717785004805 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 717785004806 putative dimer interface [polypeptide binding]; other site 717785004807 transcription elongation factor regulatory protein; Validated; Region: PRK06342 717785004808 C-term; Region: GreA_GreB; pfam01272 717785004809 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 717785004810 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 717785004811 conserved hypothetical protein; Region: TIGR02466 717785004812 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785004813 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785004814 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 717785004815 putative active site [active] 717785004816 catalytic triad [active] 717785004817 putative dimer interface [polypeptide binding]; other site 717785004818 Protein of unknown function (DUF541); Region: SIMPL; cl01077 717785004819 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 717785004820 DNA binding site [nucleotide binding] 717785004821 Int/Topo IB signature motif; other site 717785004822 active site 717785004823 catalytic residues [active] 717785004824 Phage-related protein [Function unknown]; Region: COG4695; cl01923 717785004825 Phage portal protein; Region: Phage_portal; pfam04860 717785004826 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 717785004827 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 717785004828 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 717785004829 Phage capsid family; Region: Phage_capsid; pfam05065 717785004830 Putative Ig domain; Region: He_PIG; cl09256 717785004831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004832 non-specific DNA binding site [nucleotide binding]; other site 717785004833 salt bridge; other site 717785004834 sequence-specific DNA binding site [nucleotide binding]; other site 717785004835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 717785004836 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785004837 oligomerization interface [polypeptide binding]; other site 717785004838 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 717785004839 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 717785004840 Phage Terminase; Region: Terminase_1; pfam03354 717785004841 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 717785004842 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785004843 T5orf172 domain; Region: T5orf172; pfam10544 717785004844 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 717785004845 Cytochrome c [Energy production and conversion]; Region: COG3258 717785004846 Cytochrome c; Region: Cytochrom_C; cl11414 717785004847 DsrE/DsrF-like family; Region: DrsE; cl00672 717785004848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785004849 Autotransporter beta-domain; Region: Autotransporter; cl02365 717785004850 H+ Antiporter protein; Region: 2A0121; TIGR00900 717785004851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785004852 putative substrate translocation pore; other site 717785004853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 717785004854 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 717785004855 phosphate binding site [ion binding]; other site 717785004856 Domain of unknown function (DUF369); Region: DUF369; cl00950 717785004857 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 717785004858 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785004859 dimer interface [polypeptide binding]; other site 717785004860 active site 717785004861 Phosphopantetheine attachment site; Region: PP-binding; cl09936 717785004862 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 717785004863 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785004864 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 717785004865 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 717785004866 DNA binding residues [nucleotide binding] 717785004867 putative dimer interface [polypeptide binding]; other site 717785004868 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 717785004869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785004870 S-adenosylmethionine binding site [chemical binding]; other site 717785004871 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 717785004872 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785004873 dimer interface [polypeptide binding]; other site 717785004874 active site 717785004875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785004876 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 717785004877 substrate binding site [chemical binding]; other site 717785004878 oxyanion hole (OAH) forming residues; other site 717785004879 trimer interface [polypeptide binding]; other site 717785004880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004881 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 717785004882 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 717785004883 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785004884 active site 717785004885 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 717785004886 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 717785004887 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 717785004888 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 717785004889 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 717785004890 methionine gamma-lyase; Validated; Region: PRK07049 717785004891 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785004892 homodimer interface [polypeptide binding]; other site 717785004893 substrate-cofactor binding pocket; other site 717785004894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785004895 catalytic residue [active] 717785004896 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 717785004897 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 717785004898 active site 717785004899 catalytic residues [active] 717785004900 metal binding site [ion binding]; metal-binding site 717785004901 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 717785004902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785004903 Coenzyme A binding pocket [chemical binding]; other site 717785004904 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785004905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785004907 salt bridge; other site 717785004908 non-specific DNA binding site [nucleotide binding]; other site 717785004909 sequence-specific DNA binding site [nucleotide binding]; other site 717785004910 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 717785004911 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785004912 putative NAD(P) binding site [chemical binding]; other site 717785004913 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 717785004914 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717785004915 active site 717785004916 HIGH motif; other site 717785004917 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 717785004918 KMSKS motif; other site 717785004919 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 717785004920 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 717785004921 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 717785004922 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785004923 HIGH motif; other site 717785004924 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785004925 active site 717785004926 KMSKS motif; other site 717785004927 NAD synthetase; Provisional; Region: PRK13981 717785004928 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 717785004929 multimer interface [polypeptide binding]; other site 717785004930 active site 717785004931 catalytic triad [active] 717785004932 protein interface 1 [polypeptide binding]; other site 717785004933 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 717785004934 homodimer interface [polypeptide binding]; other site 717785004935 NAD binding pocket [chemical binding]; other site 717785004936 ATP binding pocket [chemical binding]; other site 717785004937 Mg binding site [ion binding]; other site 717785004938 active-site loop [active] 717785004939 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 717785004940 short chain dehydrogenase; Provisional; Region: PRK07063 717785004941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785004942 NAD(P) binding site [chemical binding]; other site 717785004943 active site 717785004944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004945 glutathione reductase; Validated; Region: PRK06116 717785004946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004947 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785004948 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 717785004949 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 717785004950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785004951 active site 717785004952 dimer interface [polypeptide binding]; other site 717785004953 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785004954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785004955 motif II; other site 717785004956 DsrE/DsrF-like family; Region: DrsE; cl00672 717785004957 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 717785004958 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 717785004959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785004960 DNA binding site [nucleotide binding] 717785004961 Int/Topo IB signature motif; other site 717785004962 active site 717785004963 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785004964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785004965 non-specific DNA binding site [nucleotide binding]; other site 717785004966 salt bridge; other site 717785004967 sequence-specific DNA binding site [nucleotide binding]; other site 717785004968 Cupin domain; Region: Cupin_2; cl09118 717785004969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785004970 classical (c) SDRs; Region: SDR_c; cd05233 717785004971 NAD(P) binding site [chemical binding]; other site 717785004972 active site 717785004973 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785004974 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785004975 Walker A/P-loop; other site 717785004976 ATP binding site [chemical binding]; other site 717785004977 Q-loop/lid; other site 717785004978 ABC transporter signature motif; other site 717785004979 Walker B; other site 717785004980 D-loop; other site 717785004981 H-loop/switch region; other site 717785004982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785004983 dimer interface [polypeptide binding]; other site 717785004984 conserved gate region; other site 717785004985 putative PBP binding loops; other site 717785004986 ABC-ATPase subunit interface; other site 717785004987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785004988 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 717785004989 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 717785004990 metal binding site [ion binding]; metal-binding site 717785004991 dimer interface [polypeptide binding]; other site 717785004992 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785004993 metal binding site 2 [ion binding]; metal-binding site 717785004994 putative DNA binding helix; other site 717785004995 metal binding site 1 [ion binding]; metal-binding site 717785004996 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 717785004997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785004998 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 717785004999 lipoyl attachment site [posttranslational modification]; other site 717785005000 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785005001 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785005002 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 717785005003 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 717785005004 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785005005 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 717785005006 homotrimer interaction site [polypeptide binding]; other site 717785005007 putative active site [active] 717785005008 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785005009 homotrimer interaction site [polypeptide binding]; other site 717785005010 putative active site [active] 717785005011 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 717785005012 homotrimer interaction site [polypeptide binding]; other site 717785005013 putative active site [active] 717785005014 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 717785005015 dimerization interface [polypeptide binding]; other site 717785005016 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 717785005017 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 717785005018 [2Fe-2S] cluster binding site [ion binding]; other site 717785005019 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 717785005020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 717785005021 dinuclear metal binding motif [ion binding]; other site 717785005022 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785005023 putative hydrophobic ligand binding site [chemical binding]; other site 717785005024 protein interface [polypeptide binding]; other site 717785005025 gate; other site 717785005026 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 717785005027 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785005028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005029 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 717785005030 NAD(P) binding site [chemical binding]; other site 717785005031 active site 717785005032 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785005033 classical (c) SDRs; Region: SDR_c; cd05233 717785005034 NAD(P) binding site [chemical binding]; other site 717785005035 active site 717785005036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785005037 dimer interface [polypeptide binding]; other site 717785005038 conserved gate region; other site 717785005039 putative PBP binding loops; other site 717785005040 ABC-ATPase subunit interface; other site 717785005041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785005042 dimer interface [polypeptide binding]; other site 717785005043 conserved gate region; other site 717785005044 putative PBP binding loops; other site 717785005045 ABC-ATPase subunit interface; other site 717785005046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785005047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785005048 Walker A/P-loop; other site 717785005049 ATP binding site [chemical binding]; other site 717785005050 Q-loop/lid; other site 717785005051 ABC transporter signature motif; other site 717785005052 Walker B; other site 717785005053 D-loop; other site 717785005054 H-loop/switch region; other site 717785005055 TOBE domain; Region: TOBE_2; cl01440 717785005056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785005057 Amidinotransferase; Region: Amidinotransf; cl12043 717785005058 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 717785005059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785005060 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 717785005061 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 717785005062 dimerization interface [polypeptide binding]; other site 717785005063 substrate binding pocket [chemical binding]; other site 717785005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 717785005065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785005066 Phage integrase family; Region: Phage_integrase; pfam00589 717785005067 DNA binding site [nucleotide binding] 717785005068 Int/Topo IB signature motif; other site 717785005069 active site 717785005070 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785005071 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 717785005072 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 717785005073 putative ion selectivity filter; other site 717785005074 putative pore gating glutamate residue; other site 717785005075 putative H+/Cl- coupling transport residue; other site 717785005076 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 717785005077 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 717785005078 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 717785005079 homodimer interface [polypeptide binding]; other site 717785005080 NADP binding site [chemical binding]; other site 717785005081 substrate binding site [chemical binding]; other site 717785005082 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 717785005083 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 717785005084 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 717785005085 putative active site [active] 717785005086 putative substrate binding site [chemical binding]; other site 717785005087 putative cosubstrate binding site; other site 717785005088 catalytic site [active] 717785005089 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246 717785005090 FAD binding site [chemical binding]; other site 717785005091 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 717785005092 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 717785005093 active site 717785005094 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 717785005095 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 717785005096 FAD binding pocket [chemical binding]; other site 717785005097 FAD binding motif [chemical binding]; other site 717785005098 phosphate binding motif [ion binding]; other site 717785005099 beta-alpha-beta structure motif; other site 717785005100 NAD(p) ribose binding residues [chemical binding]; other site 717785005101 NAD binding pocket [chemical binding]; other site 717785005102 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 717785005103 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785005104 catalytic loop [active] 717785005105 iron binding site [ion binding]; other site 717785005106 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 717785005107 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 717785005108 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 717785005109 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 717785005110 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 717785005111 B12 binding site [chemical binding]; other site 717785005112 cobalt ligand [ion binding]; other site 717785005113 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 717785005114 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 717785005115 Tetrahydromethanopterin S-methyltransferase MtrH subunit; Region: MtrH; pfam02007 717785005116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005118 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 717785005119 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 717785005120 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 717785005121 dimerization interface [polypeptide binding]; other site 717785005122 active site 717785005123 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 717785005124 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 717785005125 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 717785005126 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 717785005127 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 717785005128 putative dimer interface [polypeptide binding]; other site 717785005129 active site pocket [active] 717785005130 putative cataytic base [active] 717785005131 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 717785005132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785005133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005134 homodimer interface [polypeptide binding]; other site 717785005135 catalytic residue [active] 717785005136 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785005137 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 717785005138 CbiD; Region: CbiD; cl00828 717785005139 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785005140 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 717785005141 putative FMN binding site [chemical binding]; other site 717785005142 cobyric acid synthase; Provisional; Region: PRK00784 717785005143 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785005144 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785005145 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 717785005146 catalytic triad [active] 717785005147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005149 Transposase domain (DUF772); Region: DUF772; cl12084 717785005150 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 717785005151 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 717785005152 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 717785005153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005154 ATP binding site [chemical binding]; other site 717785005155 substrate interface [chemical binding]; other site 717785005156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785005157 LexA repressor; Validated; Region: PRK00215 717785005158 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 717785005159 Catalytic site [active] 717785005160 Family of unknown function (DUF500); Region: DUF500; cl01109 717785005161 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 717785005162 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785005163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 717785005164 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 717785005165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785005166 catalytic residue [active] 717785005167 threonine dehydratase; Provisional; Region: PRK07334 717785005168 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 717785005169 tetramer interface [polypeptide binding]; other site 717785005170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005171 catalytic residue [active] 717785005172 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 717785005173 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 717785005174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005175 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785005176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785005177 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785005178 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 717785005179 putative C-terminal domain interface [polypeptide binding]; other site 717785005180 putative GSH binding site (G-site) [chemical binding]; other site 717785005181 putative dimer interface [polypeptide binding]; other site 717785005182 GST_C family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_C_GTT2_like; cd03182 717785005183 putative N-terminal domain interface [polypeptide binding]; other site 717785005184 putative dimer interface [polypeptide binding]; other site 717785005185 putative substrate binding pocket (H-site) [chemical binding]; other site 717785005186 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785005187 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785005188 Catalytic site; other site 717785005189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785005190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785005191 dimer interface [polypeptide binding]; other site 717785005192 phosphorylation site [posttranslational modification] 717785005193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005194 ATP binding site [chemical binding]; other site 717785005195 Mg2+ binding site [ion binding]; other site 717785005196 G-X-G motif; other site 717785005197 Predicted aspartyl protease [General function prediction only]; Region: COG3577 717785005198 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 717785005199 catalytic motif [active] 717785005200 Catalytic residue [active] 717785005201 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 717785005202 catalytic motif [active] 717785005203 Catalytic residue [active] 717785005204 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 717785005205 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 717785005206 active site 717785005207 substrate binding site [chemical binding]; other site 717785005208 metal binding site [ion binding]; metal-binding site 717785005209 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 717785005210 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 717785005211 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 717785005212 FMN binding site [chemical binding]; other site 717785005213 active site 717785005214 catalytic residues [active] 717785005215 substrate binding site [chemical binding]; other site 717785005216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005217 NAD(P) binding site [chemical binding]; other site 717785005218 active site 717785005219 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785005220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785005221 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785005222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785005223 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785005224 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785005225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785005226 binding surface 717785005227 TPR motif; other site 717785005228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785005229 binding surface 717785005230 TPR motif; other site 717785005231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785005232 binding surface 717785005233 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 717785005234 TPR motif; other site 717785005235 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785005236 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785005237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785005238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785005239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785005240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785005241 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 717785005243 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785005244 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 717785005245 Walker A/P-loop; other site 717785005246 ATP binding site [chemical binding]; other site 717785005247 Q-loop/lid; other site 717785005248 ABC transporter signature motif; other site 717785005249 Walker B; other site 717785005250 D-loop; other site 717785005251 H-loop/switch region; other site 717785005252 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 717785005253 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 717785005254 urea carboxylase; Region: urea_carbox; TIGR02712 717785005255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785005256 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785005257 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 717785005258 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 717785005259 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 717785005260 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 717785005261 carboxyltransferase (CT) interaction site; other site 717785005262 biotinylation site [posttranslational modification]; other site 717785005263 allophanate hydrolase; Provisional; Region: PRK08186 717785005264 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 717785005265 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 717785005266 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 717785005267 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 717785005268 Moco binding site; other site 717785005269 metal coordination site [ion binding]; other site 717785005270 dimerization interface [polypeptide binding]; other site 717785005271 Cytochrome c; Region: Cytochrom_C; cl11414 717785005272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785005273 S-adenosylmethionine binding site [chemical binding]; other site 717785005274 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 717785005275 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 717785005276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 717785005277 dimer interface [polypeptide binding]; other site 717785005278 active site 717785005279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785005280 catalytic residues [active] 717785005281 substrate binding site [chemical binding]; other site 717785005282 aminopeptidase N; Provisional; Region: pepN; PRK14015 717785005283 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 717785005284 active site 717785005285 Zn binding site [ion binding]; other site 717785005286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785005287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785005288 dimer interface [polypeptide binding]; other site 717785005289 phosphorylation site [posttranslational modification] 717785005290 Predicted integral membrane protein [Function unknown]; Region: COG5612 717785005291 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 717785005292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785005293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785005294 DNA binding residues [nucleotide binding] 717785005295 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 717785005296 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785005297 metal binding triad; other site 717785005298 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785005299 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785005300 metal binding triad; other site 717785005301 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785005302 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005303 dimerization interface [polypeptide binding]; other site 717785005304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785005305 dimer interface [polypeptide binding]; other site 717785005306 phosphorylation site [posttranslational modification] 717785005307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005308 ATP binding site [chemical binding]; other site 717785005309 Mg2+ binding site [ion binding]; other site 717785005310 G-X-G motif; other site 717785005311 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 717785005312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005313 active site 717785005314 phosphorylation site [posttranslational modification] 717785005315 intermolecular recognition site; other site 717785005316 dimerization interface [polypeptide binding]; other site 717785005317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785005318 DNA binding site [nucleotide binding] 717785005319 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785005320 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 717785005321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785005322 protein binding site [polypeptide binding]; other site 717785005323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785005324 protein binding site [polypeptide binding]; other site 717785005325 Cytochrome C biogenesis protein; Region: CcmH; cl01179 717785005326 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 717785005327 CcmE; Region: CcmE; cl00994 717785005328 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 717785005329 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 717785005330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785005331 binding surface 717785005332 TPR motif; other site 717785005333 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 717785005334 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 717785005335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 717785005336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005337 ATP binding site [chemical binding]; other site 717785005338 Mg2+ binding site [ion binding]; other site 717785005339 G-X-G motif; other site 717785005340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785005341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005342 active site 717785005343 phosphorylation site [posttranslational modification] 717785005344 intermolecular recognition site; other site 717785005345 dimerization interface [polypeptide binding]; other site 717785005346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785005347 DNA binding site [nucleotide binding] 717785005348 NlpC/P60 family; Region: NLPC_P60; cl11438 717785005349 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 717785005350 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 717785005351 NlpC/P60 family; Region: NLPC_P60; cl11438 717785005352 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 717785005353 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 717785005354 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 717785005355 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 717785005356 Phage-related minor tail protein [Function unknown]; Region: COG5281 717785005357 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 717785005358 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 717785005359 Phage major tail protein 2; Region: Phage_tail_2; cl11463 717785005360 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 717785005361 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785005362 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 717785005363 oligomerization interface [polypeptide binding]; other site 717785005364 Phage capsid family; Region: Phage_capsid; pfam05065 717785005365 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 717785005366 Phage-related protein [Function unknown]; Region: COG4695; cl01923 717785005367 Phage portal protein; Region: Phage_portal; pfam04860 717785005368 Uncharacterized conserved protein [Function unknown]; Region: COG5323 717785005369 Fe-S metabolism associated domain; Region: SufE; cl00951 717785005370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005371 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005372 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 717785005373 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 717785005374 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 717785005375 Transglycosylase; Region: Transgly; cl07896 717785005376 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 717785005377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785005378 Flagellin N-methylase; Region: FliB; cl00497 717785005379 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 717785005380 DnaA box-binding interface [nucleotide binding]; other site 717785005381 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 717785005382 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 717785005383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785005384 YCII-related domain; Region: YCII; cl00999 717785005385 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 717785005386 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785005387 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 717785005388 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 717785005389 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 717785005390 putative FMN binding site [chemical binding]; other site 717785005391 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785005392 metal ion-dependent adhesion site (MIDAS); other site 717785005393 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717785005394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785005395 substrate binding pocket [chemical binding]; other site 717785005396 membrane-bound complex binding site; other site 717785005397 hinge residues; other site 717785005398 cystathionine beta-lyase; Provisional; Region: PRK05967 717785005399 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785005400 homodimer interface [polypeptide binding]; other site 717785005401 substrate-cofactor binding pocket; other site 717785005402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005403 catalytic residue [active] 717785005404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785005405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785005406 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785005407 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 717785005408 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862 717785005409 nucleotide binding site [chemical binding]; other site 717785005410 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 717785005411 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 717785005412 active site 717785005413 DNA binding site [nucleotide binding] 717785005414 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 717785005415 DNA binding site [nucleotide binding] 717785005416 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 717785005417 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 717785005418 putative DNA binding site [nucleotide binding]; other site 717785005419 putative homodimer interface [polypeptide binding]; other site 717785005420 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 717785005421 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 717785005422 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785005423 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 717785005424 alpha subunit interaction interface [polypeptide binding]; other site 717785005425 Walker A motif; other site 717785005426 ATP binding site [chemical binding]; other site 717785005427 Walker B motif; other site 717785005428 inhibitor binding site; inhibition site 717785005429 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785005430 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 717785005431 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 717785005432 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 717785005433 ATP synthase A chain; Region: ATP-synt_A; cl00413 717785005434 ATP synthase subunit C; Region: ATP-synt_C; cl00466 717785005435 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 717785005436 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 717785005437 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 717785005438 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785005439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785005440 Walker A motif; other site 717785005441 ATP binding site [chemical binding]; other site 717785005442 Walker B motif; other site 717785005443 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785005444 ATP synthase; Region: ATP-synt; cl00365 717785005445 Flavin Reductases; Region: FlaRed; cl00801 717785005446 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785005447 putative metal binding site [ion binding]; other site 717785005448 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785005449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785005450 N-terminal plug; other site 717785005451 ligand-binding site [chemical binding]; other site 717785005452 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 717785005453 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 717785005454 active site 717785005455 metal binding site [ion binding]; metal-binding site 717785005456 nudix motif; other site 717785005457 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 717785005458 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 717785005459 CsbD-like; Region: CsbD; cl01272 717785005460 Mechanosensitive ion channel; Region: MS_channel; pfam00924 717785005461 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 717785005462 hypothetical protein; Provisional; Region: PRK10279 717785005463 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785005464 nucleophile elbow; other site 717785005465 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785005466 Low affinity iron permease; Region: Iron_permease; cl12096 717785005467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785005468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005469 active site 717785005470 phosphorylation site [posttranslational modification] 717785005471 intermolecular recognition site; other site 717785005472 dimerization interface [polypeptide binding]; other site 717785005473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785005474 DNA binding residues [nucleotide binding] 717785005475 dimerization interface [polypeptide binding]; other site 717785005476 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005477 Histidine kinase; Region: HisKA_3; pfam07730 717785005478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005479 ATP binding site [chemical binding]; other site 717785005480 Mg2+ binding site [ion binding]; other site 717785005481 G-X-G motif; other site 717785005482 putative S-transferase; Provisional; Region: PRK11752 717785005483 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 717785005484 C-terminal domain interface [polypeptide binding]; other site 717785005485 GSH binding site (G-site) [chemical binding]; other site 717785005486 dimer interface [polypeptide binding]; other site 717785005487 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 717785005488 dimer interface [polypeptide binding]; other site 717785005489 N-terminal domain interface [polypeptide binding]; other site 717785005490 putative substrate binding pocket (H-site) [chemical binding]; other site 717785005491 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 717785005492 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 717785005493 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 717785005494 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 717785005495 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 717785005496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785005497 S-adenosylmethionine binding site [chemical binding]; other site 717785005498 alanyl-tRNA synthetase; Region: PLN02900 717785005499 Cupin domain; Region: Cupin_2; cl09118 717785005500 Helix-turn-helix domain; Region: HTH_18; pfam12833 717785005501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785005502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785005504 putative substrate translocation pore; other site 717785005505 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 717785005506 DHH family; Region: DHH; pfam01368 717785005507 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 717785005508 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 717785005509 putative active site [active] 717785005510 homoserine dehydrogenase; Provisional; Region: PRK06349 717785005511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005512 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 717785005513 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 717785005514 aspartate aminotransferase; Provisional; Region: PRK07681 717785005515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785005516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005517 homodimer interface [polypeptide binding]; other site 717785005518 catalytic residue [active] 717785005519 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 717785005520 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 717785005521 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 717785005522 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 717785005523 homodimer interface [polypeptide binding]; other site 717785005524 substrate-cofactor binding pocket; other site 717785005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785005526 catalytic residue [active] 717785005527 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 717785005528 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 717785005529 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 717785005530 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 717785005531 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 717785005532 CAP-like domain; other site 717785005533 Active site [active] 717785005534 primary dimer interface [polypeptide binding]; other site 717785005535 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 717785005536 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 717785005537 classical (c) SDRs; Region: SDR_c; cd05233 717785005538 NAD(P) binding site [chemical binding]; other site 717785005539 active site 717785005540 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 717785005541 putative active site [active] 717785005542 putative metal binding residues [ion binding]; other site 717785005543 signature motif; other site 717785005544 putative dimer interface [polypeptide binding]; other site 717785005545 putative phosphate binding site [ion binding]; other site 717785005546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785005547 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 717785005548 putative homotetramer interface [polypeptide binding]; other site 717785005549 putative homodimer interface [polypeptide binding]; other site 717785005550 putative allosteric switch controlling residues; other site 717785005551 putative metal binding site [ion binding]; other site 717785005552 putative homodimer-homodimer interface [polypeptide binding]; other site 717785005553 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 717785005554 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 717785005555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785005556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785005557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785005558 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785005559 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785005560 active site 717785005561 catalytic tetrad [active] 717785005562 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 717785005563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005564 cytochrome P450 83B1; Provisional; Region: PLN03234 717785005565 Cytochrome P450; Region: p450; cl12078 717785005566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005567 NAD(P) binding site [chemical binding]; other site 717785005568 active site 717785005569 Leucine carboxyl methyltransferase; Region: LCM; cl01306 717785005570 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785005571 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785005572 P-loop; other site 717785005573 Magnesium ion binding site [ion binding]; other site 717785005574 Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is...; Region: GST_N_Metaxin_like; cd03080 717785005575 putative C-terminal domain interface [polypeptide binding]; other site 717785005576 putative GSH binding site [chemical binding]; other site 717785005577 putative dimer interface [polypeptide binding]; other site 717785005578 GST_C family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its...; Region: GST_C_Metaxin; cd03193 717785005579 putative N-terminal domain interface [polypeptide binding]; other site 717785005580 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 717785005581 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 717785005582 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 717785005583 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 717785005584 transcriptional regulator SlyA; Provisional; Region: PRK03573 717785005585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785005586 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 717785005587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785005588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785005589 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 717785005590 Domain of unknown function DUF21; Region: DUF21; pfam01595 717785005591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785005592 Transporter associated domain; Region: CorC_HlyC; pfam03471 717785005593 ATP12 chaperone protein; Region: ATP12; cl02228 717785005594 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785005595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785005596 motif II; other site 717785005597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 717785005598 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 717785005599 active site 717785005600 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 717785005601 Putative ParB-like nuclease; Region: ParBc_2; cl01772 717785005602 recombination factor protein RarA; Reviewed; Region: PRK13342 717785005603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785005604 Walker A motif; other site 717785005605 ATP binding site [chemical binding]; other site 717785005606 Walker B motif; other site 717785005607 arginine finger; other site 717785005608 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 717785005609 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 717785005610 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785005611 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 717785005612 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785005613 protein binding site [polypeptide binding]; other site 717785005614 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785005615 protein binding site [polypeptide binding]; other site 717785005616 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785005617 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 717785005618 NADP binding site [chemical binding]; other site 717785005619 putative substrate binding site [chemical binding]; other site 717785005620 active site 717785005621 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 717785005622 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 717785005623 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 717785005624 alphaNTD - beta interaction site [polypeptide binding]; other site 717785005625 alphaNTD homodimer interface [polypeptide binding]; other site 717785005626 alphaNTD - beta' interaction site [polypeptide binding]; other site 717785005627 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 717785005628 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 717785005629 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 717785005630 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 717785005631 adenylate kinase; Reviewed; Region: adk; PRK00279 717785005632 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 717785005633 AMP-binding site [chemical binding]; other site 717785005634 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 717785005635 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 717785005636 SecY translocase; Region: SecY; pfam00344 717785005637 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 717785005638 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 717785005639 23S rRNA binding site [nucleotide binding]; other site 717785005640 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 717785005641 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 717785005642 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 717785005643 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 717785005644 5S rRNA interface [nucleotide binding]; other site 717785005645 23S rRNA interface [nucleotide binding]; other site 717785005646 L5 interface [polypeptide binding]; other site 717785005647 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 717785005648 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717785005649 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 717785005650 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 717785005651 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 717785005652 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 717785005653 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 717785005654 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 717785005655 KOW motif; Region: KOW; cl00354 717785005656 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 717785005657 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 717785005658 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 717785005659 putative translocon interaction site; other site 717785005660 23S rRNA interface [nucleotide binding]; other site 717785005661 signal recognition particle (SRP54) interaction site; other site 717785005662 L23 interface [polypeptide binding]; other site 717785005663 trigger factor interaction site; other site 717785005664 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 717785005665 23S rRNA interface [nucleotide binding]; other site 717785005666 5S rRNA interface [nucleotide binding]; other site 717785005667 putative antibiotic binding site [chemical binding]; other site 717785005668 L25 interface [polypeptide binding]; other site 717785005669 L27 interface [polypeptide binding]; other site 717785005670 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 717785005671 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 717785005672 G-X-X-G motif; other site 717785005673 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 717785005674 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 717785005675 putative translocon binding site; other site 717785005676 protein-rRNA interface [nucleotide binding]; other site 717785005677 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 717785005678 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 717785005679 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 717785005680 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 717785005681 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 717785005682 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 717785005683 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 717785005684 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 717785005685 elongation factor Tu; Reviewed; Region: PRK00049 717785005686 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 717785005687 G1 box; other site 717785005688 GEF interaction site [polypeptide binding]; other site 717785005689 GTP/Mg2+ binding site [chemical binding]; other site 717785005690 Switch I region; other site 717785005691 G2 box; other site 717785005692 G3 box; other site 717785005693 Switch II region; other site 717785005694 G4 box; other site 717785005695 G5 box; other site 717785005696 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 717785005697 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 717785005698 Antibiotic Binding Site [chemical binding]; other site 717785005699 elongation factor G; Reviewed; Region: PRK00007 717785005700 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 717785005701 G1 box; other site 717785005702 putative GEF interaction site [polypeptide binding]; other site 717785005703 GTP/Mg2+ binding site [chemical binding]; other site 717785005704 Switch I region; other site 717785005705 G2 box; other site 717785005706 G3 box; other site 717785005707 Switch II region; other site 717785005708 G4 box; other site 717785005709 G5 box; other site 717785005710 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 717785005711 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 717785005712 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 717785005713 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 717785005714 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 717785005715 S17 interaction site [polypeptide binding]; other site 717785005716 S8 interaction site; other site 717785005717 16S rRNA interaction site [nucleotide binding]; other site 717785005718 streptomycin interaction site [chemical binding]; other site 717785005719 23S rRNA interaction site [nucleotide binding]; other site 717785005720 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 717785005721 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 717785005722 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 717785005723 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 717785005724 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 717785005725 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 717785005726 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 717785005727 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 717785005728 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 717785005729 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 717785005730 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 717785005731 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 717785005732 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 717785005733 DNA binding site [nucleotide binding] 717785005734 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 717785005735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 717785005736 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 717785005737 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 717785005738 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 717785005739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 717785005740 RPB12 interaction site [polypeptide binding]; other site 717785005741 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 717785005742 RPB11 interaction site [polypeptide binding]; other site 717785005743 RPB12 interaction site [polypeptide binding]; other site 717785005744 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 717785005745 RPB1 interaction site [polypeptide binding]; other site 717785005746 RPB11 interaction site [polypeptide binding]; other site 717785005747 RPB10 interaction site [polypeptide binding]; other site 717785005748 RPB3 interaction site [polypeptide binding]; other site 717785005749 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 717785005750 peripheral dimer interface [polypeptide binding]; other site 717785005751 core dimer interface [polypeptide binding]; other site 717785005752 L10 interface [polypeptide binding]; other site 717785005753 L11 interface [polypeptide binding]; other site 717785005754 putative EF-Tu interaction site [polypeptide binding]; other site 717785005755 putative EF-G interaction site [polypeptide binding]; other site 717785005756 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 717785005757 23S rRNA interface [nucleotide binding]; other site 717785005758 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 717785005759 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 717785005760 mRNA/rRNA interface [nucleotide binding]; other site 717785005761 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 717785005762 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 717785005763 23S rRNA interface [nucleotide binding]; other site 717785005764 L7/L12 interface [polypeptide binding]; other site 717785005765 putative thiostrepton binding site; other site 717785005766 L25 interface [polypeptide binding]; other site 717785005767 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 717785005768 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 717785005769 putative homodimer interface [polypeptide binding]; other site 717785005770 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 717785005771 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 717785005772 Domain of unknown function (DUF74); Region: DUF74; cl00426 717785005773 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 717785005774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785005775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785005776 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 717785005777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785005778 active site 717785005779 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 717785005780 putative NAD(P) binding site [chemical binding]; other site 717785005781 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 717785005782 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785005783 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785005784 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 717785005785 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 717785005786 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785005787 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 717785005788 Walker A/P-loop; other site 717785005789 ATP binding site [chemical binding]; other site 717785005790 Q-loop/lid; other site 717785005791 ABC transporter signature motif; other site 717785005792 Walker B; other site 717785005793 D-loop; other site 717785005794 H-loop/switch region; other site 717785005795 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 717785005796 dimerization interface [polypeptide binding]; other site 717785005797 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 717785005798 active site 717785005799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 717785005801 enoyl-CoA hydratase; Validated; Region: PRK08139 717785005802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785005803 substrate binding site [chemical binding]; other site 717785005804 oxyanion hole (OAH) forming residues; other site 717785005805 trimer interface [polypeptide binding]; other site 717785005806 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 717785005807 23S rRNA interface [nucleotide binding]; other site 717785005808 L3 interface [polypeptide binding]; other site 717785005809 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 717785005810 Integral membrane protein TerC family; Region: TerC; cl10468 717785005811 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 717785005812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785005813 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 717785005814 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 717785005815 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 717785005816 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785005817 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 717785005818 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005819 dimerization interface [polypeptide binding]; other site 717785005820 Histidine kinase; Region: HisKA_3; pfam07730 717785005821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005822 ATP binding site [chemical binding]; other site 717785005823 Mg2+ binding site [ion binding]; other site 717785005824 G-X-G motif; other site 717785005825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005827 active site 717785005828 phosphorylation site [posttranslational modification] 717785005829 intermolecular recognition site; other site 717785005830 dimerization interface [polypeptide binding]; other site 717785005831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785005832 DNA binding residues [nucleotide binding] 717785005833 dimerization interface [polypeptide binding]; other site 717785005834 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 717785005835 putative hydrophobic ligand binding site [chemical binding]; other site 717785005836 protein interface [polypeptide binding]; other site 717785005837 gate; other site 717785005838 two-component response regulator; Provisional; Region: PRK09191 717785005839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 717785005840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005841 active site 717785005842 phosphorylation site [posttranslational modification] 717785005843 intermolecular recognition site; other site 717785005844 dimerization interface [polypeptide binding]; other site 717785005845 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785005846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785005847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785005848 DNA binding residues [nucleotide binding] 717785005849 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717785005850 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005851 dimerization interface [polypeptide binding]; other site 717785005852 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005853 dimerization interface [polypeptide binding]; other site 717785005854 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005855 dimerization interface [polypeptide binding]; other site 717785005856 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 717785005857 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005858 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005859 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785005860 dimerization interface [polypeptide binding]; other site 717785005861 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005862 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005863 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785005864 GAF domain; Region: GAF; cl00853 717785005865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785005866 dimer interface [polypeptide binding]; other site 717785005867 phosphorylation site [posttranslational modification] 717785005868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785005869 ATP binding site [chemical binding]; other site 717785005870 Mg2+ binding site [ion binding]; other site 717785005871 G-X-G motif; other site 717785005872 Response regulator receiver domain; Region: Response_reg; pfam00072 717785005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005874 active site 717785005875 phosphorylation site [posttranslational modification] 717785005876 intermolecular recognition site; other site 717785005877 dimerization interface [polypeptide binding]; other site 717785005878 Response regulator receiver domain; Region: Response_reg; pfam00072 717785005879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005880 active site 717785005881 phosphorylation site [posttranslational modification] 717785005882 intermolecular recognition site; other site 717785005883 dimerization interface [polypeptide binding]; other site 717785005884 Response regulator receiver domain; Region: Response_reg; pfam00072 717785005885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005886 active site 717785005887 phosphorylation site [posttranslational modification] 717785005888 intermolecular recognition site; other site 717785005889 dimerization interface [polypeptide binding]; other site 717785005890 Response regulator receiver domain; Region: Response_reg; pfam00072 717785005891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005892 active site 717785005893 phosphorylation site [posttranslational modification] 717785005894 intermolecular recognition site; other site 717785005895 dimerization interface [polypeptide binding]; other site 717785005896 putative diguanylate cyclase; Provisional; Region: PRK09776 717785005897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785005898 Histidine kinase; Region: HisKA_2; cl06527 717785005899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717785005900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785005901 active site 717785005902 phosphorylation site [posttranslational modification] 717785005903 intermolecular recognition site; other site 717785005904 dimerization interface [polypeptide binding]; other site 717785005905 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 717785005906 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 717785005907 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 717785005908 hypothetical protein; Provisional; Region: PRK13559 717785005909 Histidine kinase; Region: HisKA_2; cl06527 717785005910 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 717785005911 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 717785005912 active site 717785005913 homotetramer interface [polypeptide binding]; other site 717785005914 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 717785005915 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 717785005916 ATP binding site [chemical binding]; other site 717785005917 substrate binding site [chemical binding]; other site 717785005918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785005919 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 717785005920 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 717785005921 putative metal binding site [ion binding]; other site 717785005922 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785005923 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 717785005924 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 717785005925 Gram-negative bacterial tonB protein; Region: TonB; cl10048 717785005926 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 717785005927 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785005928 N-terminal plug; other site 717785005929 ligand-binding site [chemical binding]; other site 717785005930 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 717785005931 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785005932 Sel1 repeat; Region: Sel1; cl02723 717785005933 Sel1 repeat; Region: Sel1; cl02723 717785005934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 717785005935 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469 717785005936 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 717785005937 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 717785005938 ApbE family; Region: ApbE; cl00643 717785005939 integrase; Provisional; Region: PRK09692 717785005940 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785005941 active site 717785005942 Int/Topo IB signature motif; other site 717785005943 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 717785005944 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 717785005945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785005946 Walker A/P-loop; other site 717785005947 ATP binding site [chemical binding]; other site 717785005948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785005949 ABC transporter signature motif; other site 717785005950 Walker B; other site 717785005951 D-loop; other site 717785005952 H-loop/switch region; other site 717785005953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3680 717785005954 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785005955 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 717785005956 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 717785005957 DNA binding residues [nucleotide binding] 717785005958 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 717785005959 IHF dimer interface [polypeptide binding]; other site 717785005960 IHF - DNA interface [nucleotide binding]; other site 717785005961 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 717785005962 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785005963 dimer interface [polypeptide binding]; other site 717785005964 active site 717785005965 CoA binding pocket [chemical binding]; other site 717785005966 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 717785005967 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 717785005968 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 717785005969 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 717785005970 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 717785005971 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 717785005972 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 717785005973 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 717785005974 homotrimer interaction site [polypeptide binding]; other site 717785005975 putative active site [active] 717785005976 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 717785005977 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 717785005978 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 717785005979 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 717785005980 Glucose inhibited division protein A; Region: GIDA; pfam01134 717785005981 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 717785005982 active site 717785005983 catalytic triad [active] 717785005984 oxyanion hole [active] 717785005985 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 717785005986 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as...; Region: Mth938-like; cd00248 717785005987 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 717785005988 Protein export membrane protein; Region: SecD_SecF; cl14618 717785005989 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 717785005990 Protein export membrane protein; Region: SecD_SecF; cl14618 717785005991 Preprotein translocase subunit; Region: YajC; cl00806 717785005992 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 717785005993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785005994 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 717785005995 putative peptidoglycan binding site; other site 717785005996 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 717785005997 putative peptidoglycan binding site; other site 717785005998 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785005999 Survival protein SurE; Region: SurE; cl00448 717785006000 seryl-tRNA synthetase; Provisional; Region: PRK05431 717785006001 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 717785006002 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 717785006003 dimer interface [polypeptide binding]; other site 717785006004 active site 717785006005 motif 1; other site 717785006006 motif 2; other site 717785006007 motif 3; other site 717785006008 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 717785006009 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 717785006010 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 717785006011 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 717785006012 ScpA/B protein; Region: ScpA_ScpB; cl00598 717785006013 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 717785006014 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 717785006015 Sporulation related domain; Region: SPOR; cl10051 717785006016 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 717785006017 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 717785006018 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 717785006019 active site 717785006020 HIGH motif; other site 717785006021 KMSK motif region; other site 717785006022 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 717785006023 tRNA binding surface [nucleotide binding]; other site 717785006024 anticodon binding site; other site 717785006025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 717785006026 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 717785006027 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 717785006028 putative phosphate binding site [ion binding]; other site 717785006029 putative catalytic site [active] 717785006030 active site 717785006031 metal binding site A [ion binding]; metal-binding site 717785006032 DNA binding site [nucleotide binding] 717785006033 putative AP binding site [nucleotide binding]; other site 717785006034 putative metal binding site B [ion binding]; other site 717785006035 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785006036 Dehydratase family; Region: ILVD_EDD; cl00340 717785006037 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 717785006038 Peptidase family M48; Region: Peptidase_M48; cl12018 717785006039 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 717785006040 NAD(P) binding site [chemical binding]; other site 717785006041 active site 717785006042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006043 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 717785006044 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 717785006045 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 717785006046 HIGH motif; other site 717785006047 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 717785006048 active site 717785006049 KMSKS motif; other site 717785006050 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 717785006051 tRNA binding surface [nucleotide binding]; other site 717785006052 anticodon binding site; other site 717785006053 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 717785006054 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 717785006055 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 717785006056 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 717785006057 Outer membrane efflux protein; Region: OEP; pfam02321 717785006058 Outer membrane efflux protein; Region: OEP; pfam02321 717785006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785006060 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 717785006061 Dehydratase family; Region: ILVD_EDD; cl00340 717785006062 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 717785006063 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 717785006064 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785006065 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 717785006066 Low-spin heme binding site [chemical binding]; other site 717785006067 D-pathway; other site 717785006068 Putative water exit pathway; other site 717785006069 Binuclear center (active site) [active] 717785006070 K-pathway; other site 717785006071 Putative proton exit pathway; other site 717785006072 Cytochrome c; Region: Cytochrom_C; cl11414 717785006073 Cytochrome c; Region: Cytochrom_C; cl11414 717785006074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785006075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785006077 dimerization interface [polypeptide binding]; other site 717785006078 formate dehydrogenase; Provisional; Region: PRK07574 717785006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006080 cyanate hydratase; Validated; Region: PRK02866 717785006081 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 717785006082 oligomer interface [polypeptide binding]; other site 717785006083 active site 717785006084 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 717785006085 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 717785006086 Cl- selectivity filter; other site 717785006087 Cl- binding residues [ion binding]; other site 717785006088 pore gating glutamate residue; other site 717785006089 dimer interface [polypeptide binding]; other site 717785006090 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 717785006091 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785006092 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785006093 [2Fe-2S] cluster binding site [ion binding]; other site 717785006094 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 717785006095 hydrophobic ligand binding site; other site 717785006096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785006097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785006099 dimerization interface [polypeptide binding]; other site 717785006100 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 717785006101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785006102 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 717785006103 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 717785006104 putative ligand binding site [chemical binding]; other site 717785006105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 717785006106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785006107 DNA-binding site [nucleotide binding]; DNA binding site 717785006108 FCD domain; Region: FCD; cl11656 717785006109 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785006110 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785006111 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 717785006112 FMN-binding pocket [chemical binding]; other site 717785006113 flavin binding motif; other site 717785006114 phosphate binding motif [ion binding]; other site 717785006115 beta-alpha-beta structure motif; other site 717785006116 NAD binding pocket [chemical binding]; other site 717785006117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785006118 catalytic loop [active] 717785006119 iron binding site [ion binding]; other site 717785006120 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 717785006121 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785006122 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785006123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785006124 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 717785006125 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 717785006126 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785006127 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785006128 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 717785006129 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 717785006130 NADP binding site [chemical binding]; other site 717785006131 dimer interface [polypeptide binding]; other site 717785006132 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 717785006133 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 717785006134 dimer interface [polypeptide binding]; other site 717785006135 putative tRNA-binding site [nucleotide binding]; other site 717785006136 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 717785006137 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 717785006138 FecR protein; Region: FecR; pfam04773 717785006139 CHASE2 domain; Region: CHASE2; cl01732 717785006140 cyclase homology domain; Region: CHD; cd07302 717785006141 nucleotidyl binding site; other site 717785006142 metal binding site [ion binding]; metal-binding site 717785006143 dimer interface [polypeptide binding]; other site 717785006144 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 717785006145 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 717785006146 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785006147 classical (c) SDRs; Region: SDR_c; cd05233 717785006148 NAD(P) binding site [chemical binding]; other site 717785006149 active site 717785006150 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785006151 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785006152 N-terminal plug; other site 717785006153 ligand-binding site [chemical binding]; other site 717785006154 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 717785006155 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 717785006156 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 717785006157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785006158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785006159 putative aminotransferase; Validated; Region: PRK07480 717785006160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785006161 inhibitor-cofactor binding pocket; inhibition site 717785006162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006163 catalytic residue [active] 717785006164 Peptidase C26; Region: Peptidase_C26; pfam07722 717785006165 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 717785006166 catalytic triad [active] 717785006167 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785006168 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785006169 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785006170 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 717785006171 NAD(P) binding site [chemical binding]; other site 717785006172 catalytic residues [active] 717785006173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785006174 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 717785006175 tetramerization interface [polypeptide binding]; other site 717785006176 NAD(P) binding site [chemical binding]; other site 717785006177 catalytic residues [active] 717785006178 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 717785006179 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785006180 inhibitor-cofactor binding pocket; inhibition site 717785006181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006182 catalytic residue [active] 717785006183 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 717785006184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785006185 inhibitor-cofactor binding pocket; inhibition site 717785006186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006187 catalytic residue [active] 717785006188 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 717785006189 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785006190 tetrameric interface [polypeptide binding]; other site 717785006191 NAD binding site [chemical binding]; other site 717785006192 catalytic residues [active] 717785006193 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are...; Region: sensor_globin; cd01068 717785006194 heme-binding site [chemical binding]; other site 717785006195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717785006196 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 717785006197 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 717785006198 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 717785006199 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 717785006200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785006202 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785006203 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006204 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 717785006205 thiamine monophosphate kinase; Provisional; Region: PRK05731 717785006206 ATP binding site [chemical binding]; other site 717785006207 dimerization interface [polypeptide binding]; other site 717785006208 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 717785006209 putative RNA binding site [nucleotide binding]; other site 717785006210 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 717785006211 homopentamer interface [polypeptide binding]; other site 717785006212 active site 717785006213 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 717785006214 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 717785006215 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 717785006216 dimerization interface [polypeptide binding]; other site 717785006217 active site 717785006218 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 717785006219 Lumazine binding domain; Region: Lum_binding; pfam00677 717785006220 Lumazine binding domain; Region: Lum_binding; pfam00677 717785006221 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 717785006222 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 717785006223 catalytic motif [active] 717785006224 Zn binding site [ion binding]; other site 717785006225 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 717785006226 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 717785006227 ATP cone domain; Region: ATP-cone; pfam03477 717785006228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006229 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785006230 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 717785006231 dimer interface [polypeptide binding]; other site 717785006232 glycine-pyridoxal phosphate binding site [chemical binding]; other site 717785006233 active site 717785006234 folate binding site [chemical binding]; other site 717785006235 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 717785006236 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 717785006237 substrate-cofactor binding pocket; other site 717785006238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006239 catalytic residue [active] 717785006240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785006241 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 717785006242 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006243 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785006246 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 717785006247 substrate binding site [chemical binding]; other site 717785006248 oxyanion hole (OAH) forming residues; other site 717785006249 trimer interface [polypeptide binding]; other site 717785006250 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785006251 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785006252 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 717785006253 dimer interface [polypeptide binding]; other site 717785006254 allosteric magnesium binding site [ion binding]; other site 717785006255 active site 717785006256 aspartate-rich active site metal binding site; other site 717785006257 Schiff base residues; other site 717785006258 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 717785006259 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 717785006260 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 717785006261 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 717785006262 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006263 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 717785006264 active site 717785006265 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006266 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 717785006267 TSCPD domain; Region: TSCPD; cl14834 717785006268 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 717785006269 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 717785006270 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 717785006271 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 717785006272 putative MPT binding site; other site 717785006273 Sugar fermentation stimulation protein; Region: SfsA; cl00647 717785006274 SelR domain; Region: SelR; cl00369 717785006275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785006276 metal binding site [ion binding]; metal-binding site 717785006277 active site 717785006278 I-site; other site 717785006279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785006280 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 717785006281 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785006282 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 717785006283 Protein export membrane protein; Region: SecD_SecF; cl14618 717785006284 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 717785006285 Protein export membrane protein; Region: SecD_SecF; cl14618 717785006286 O-Antigen ligase; Region: Wzy_C; cl04850 717785006287 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785006288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785006289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006290 active site 717785006291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785006292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785006293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785006294 DNA binding residues [nucleotide binding] 717785006295 dimerization interface [polypeptide binding]; other site 717785006296 Bacterial sugar transferase; Region: Bac_transf; cl00939 717785006297 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785006298 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785006299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006300 active site 717785006301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006302 active site 717785006303 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785006304 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 717785006305 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 717785006306 Walker A/P-loop; other site 717785006307 ATP binding site [chemical binding]; other site 717785006308 Q-loop/lid; other site 717785006309 ABC transporter signature motif; other site 717785006310 Walker B; other site 717785006311 D-loop; other site 717785006312 H-loop/switch region; other site 717785006313 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785006314 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785006315 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785006316 inhibitor-cofactor binding pocket; inhibition site 717785006317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006318 catalytic residue [active] 717785006319 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785006320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006321 NAD(P) binding site [chemical binding]; other site 717785006322 active site 717785006323 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785006324 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785006325 inhibitor-cofactor binding pocket; inhibition site 717785006326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006327 catalytic residue [active] 717785006328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006329 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 717785006330 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 717785006331 putative trimer interface [polypeptide binding]; other site 717785006332 putative active site [active] 717785006333 putative substrate binding site [chemical binding]; other site 717785006334 putative CoA binding site [chemical binding]; other site 717785006335 Chain length determinant protein; Region: Wzz; cl01623 717785006336 chain length determinant protein EpsF; Region: EpsF; TIGR03017 717785006337 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785006338 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 717785006339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006340 active site 717785006341 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 717785006342 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 717785006343 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785006344 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 717785006345 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 717785006346 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 717785006347 Ligand binding site [chemical binding]; other site 717785006348 hypothetical protein; Validated; Region: PRK08238 717785006349 UbiA prenyltransferase family; Region: UbiA; cl00337 717785006350 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 717785006351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785006352 Surface antigen; Region: Surface_Ag_2; cl01155 717785006353 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 717785006354 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785006355 Phosphopantetheine attachment site; Region: PP-binding; cl09936 717785006356 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 717785006357 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006358 putative trimer interface [polypeptide binding]; other site 717785006359 putative CoA binding site [chemical binding]; other site 717785006360 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006361 putative trimer interface [polypeptide binding]; other site 717785006362 putative CoA binding site [chemical binding]; other site 717785006363 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 717785006364 putative trimer interface [polypeptide binding]; other site 717785006365 putative CoA binding site [chemical binding]; other site 717785006366 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 717785006367 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 717785006368 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785006369 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 717785006370 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785006371 FRG domain; Region: FRG; pfam08867 717785006372 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 717785006373 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 717785006374 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 717785006375 putative NAD(P) binding site [chemical binding]; other site 717785006376 active site 717785006377 putative substrate binding site [chemical binding]; other site 717785006378 hypothetical protein; Provisional; Region: PRK06185 717785006379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785006380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785006381 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 717785006382 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 717785006383 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717785006384 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 717785006385 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785006386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785006387 P-loop; other site 717785006388 Magnesium ion binding site [ion binding]; other site 717785006389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785006390 Magnesium ion binding site [ion binding]; other site 717785006391 LexA repressor; Validated; Region: PRK00215 717785006392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785006393 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 717785006394 Catalytic site [active] 717785006395 Competence protein; Region: Competence; cl00471 717785006396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785006397 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 717785006398 active site 717785006399 HIGH motif; other site 717785006400 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 717785006401 active site 717785006402 KMSKS motif; other site 717785006403 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 717785006404 dimer interface [polypeptide binding]; other site 717785006405 Citrate synthase; Region: Citrate_synt; pfam00285 717785006406 active site 717785006407 citrylCoA binding site [chemical binding]; other site 717785006408 NADH binding [chemical binding]; other site 717785006409 cationic pore residues; other site 717785006410 oxalacetate/citrate binding site [chemical binding]; other site 717785006411 coenzyme A binding site [chemical binding]; other site 717785006412 catalytic triad [active] 717785006413 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 717785006414 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 717785006415 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 717785006416 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 717785006417 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 717785006418 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 717785006419 active site 717785006420 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 717785006421 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 717785006422 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 717785006423 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 717785006424 trimer interface [polypeptide binding]; other site 717785006425 active site 717785006426 UDP-GlcNAc binding site [chemical binding]; other site 717785006427 lipid binding site [chemical binding]; lipid-binding site 717785006428 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 717785006429 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 717785006430 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 717785006431 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 717785006432 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 717785006433 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 717785006434 Surface antigen; Region: Bac_surface_Ag; cl03097 717785006435 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 717785006436 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 717785006437 active site 717785006438 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 717785006439 protein binding site [polypeptide binding]; other site 717785006440 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 717785006441 putative substrate binding region [chemical binding]; other site 717785006442 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 717785006443 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 717785006444 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 717785006445 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 717785006446 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 717785006447 catalytic residue [active] 717785006448 putative FPP diphosphate binding site; other site 717785006449 putative FPP binding hydrophobic cleft; other site 717785006450 dimer interface [polypeptide binding]; other site 717785006451 putative IPP diphosphate binding site; other site 717785006452 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 717785006453 hinge region; other site 717785006454 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 717785006455 putative nucleotide binding site [chemical binding]; other site 717785006456 uridine monophosphate binding site [chemical binding]; other site 717785006457 homohexameric interface [polypeptide binding]; other site 717785006458 elongation factor Ts; Provisional; Region: tsf; PRK09377 717785006459 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 717785006460 Elongation factor TS; Region: EF_TS; pfam00889 717785006461 Elongation factor TS; Region: EF_TS; pfam00889 717785006462 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 717785006463 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 717785006464 rRNA interaction site [nucleotide binding]; other site 717785006465 S8 interaction site; other site 717785006466 putative laminin-1 binding site; other site 717785006467 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785006468 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 717785006469 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 717785006470 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 717785006471 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 717785006472 generic binding surface II; other site 717785006473 generic binding surface I; other site 717785006474 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 717785006475 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785006476 Walker A/P-loop; other site 717785006477 ATP binding site [chemical binding]; other site 717785006478 Q-loop/lid; other site 717785006479 ABC transporter signature motif; other site 717785006480 Walker B; other site 717785006481 D-loop; other site 717785006482 H-loop/switch region; other site 717785006483 LolC/E family; Region: lolCE; TIGR02212 717785006484 FtsX-like permease family; Region: FtsX; pfam02687 717785006485 prolyl-tRNA synthetase; Provisional; Region: PRK08661 717785006486 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 717785006487 dimer interface [polypeptide binding]; other site 717785006488 motif 1; other site 717785006489 active site 717785006490 motif 2; other site 717785006491 motif 3; other site 717785006492 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 717785006493 anticodon binding site; other site 717785006494 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 717785006495 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 717785006496 dimer interface [polypeptide binding]; other site 717785006497 substrate binding site [chemical binding]; other site 717785006498 metal binding site [ion binding]; metal-binding site 717785006499 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 717785006500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785006501 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 717785006502 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 717785006503 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 717785006504 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 717785006505 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 717785006506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 717785006507 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 717785006508 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 717785006509 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 717785006510 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 717785006511 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 717785006512 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 717785006513 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 717785006514 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 717785006515 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 717785006516 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 717785006517 4Fe-4S binding domain; Region: Fer4; cl02805 717785006518 4Fe-4S binding domain; Region: Fer4; cl02805 717785006519 NADH dehydrogenase; Region: NADHdh; cl00469 717785006520 NADH dehydrogenase subunit G; Validated; Region: PRK09130 717785006521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785006522 catalytic loop [active] 717785006523 iron binding site [ion binding]; other site 717785006524 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 717785006525 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 717785006526 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 717785006527 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 717785006528 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 717785006529 SLBB domain; Region: SLBB; pfam10531 717785006530 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 717785006531 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 717785006532 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 717785006533 putative dimer interface [polypeptide binding]; other site 717785006534 [2Fe-2S] cluster binding site [ion binding]; other site 717785006535 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785006536 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 717785006537 putative hydrophobic ligand binding site [chemical binding]; other site 717785006538 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 717785006539 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 717785006540 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 717785006541 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 717785006542 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 717785006543 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 717785006544 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479 717785006545 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480 717785006546 Domain of Unknown Function (DUF1520); Region: DUF1520; pfam07480 717785006547 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 717785006548 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 717785006549 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717785006550 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 717785006551 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 717785006552 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 717785006553 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 717785006554 IHF dimer interface [polypeptide binding]; other site 717785006555 IHF - DNA interface [nucleotide binding]; other site 717785006556 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 717785006557 Found in ATP-dependent protease La (LON); Region: LON; cl01056 717785006558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785006559 Walker A motif; other site 717785006560 ATP binding site [chemical binding]; other site 717785006561 Walker B motif; other site 717785006562 arginine finger; other site 717785006563 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 717785006564 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 717785006565 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 717785006566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785006567 Walker A motif; other site 717785006568 ATP binding site [chemical binding]; other site 717785006569 Walker B motif; other site 717785006570 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785006571 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 717785006572 oligomer interface [polypeptide binding]; other site 717785006573 active site residues [active] 717785006574 trigger factor; Provisional; Region: tig; PRK01490 717785006575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 717785006576 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 717785006577 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 717785006578 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 717785006579 molybdopterin cofactor binding site; other site 717785006580 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 717785006581 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 717785006582 molybdopterin cofactor binding site; other site 717785006583 Fe-S containing; Region: FDH-beta; TIGR01582 717785006584 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 717785006585 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 717785006586 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785006587 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564; cl11689 717785006588 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 717785006589 selenophosphate synthetase; Provisional; Region: PRK00943 717785006590 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 717785006591 dimerization interface [polypeptide binding]; other site 717785006592 putative ATP binding site [chemical binding]; other site 717785006593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 717785006594 active site 717785006595 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 717785006596 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 717785006597 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 717785006598 G1 box; other site 717785006599 putative GEF interaction site [polypeptide binding]; other site 717785006600 GTP/Mg2+ binding site [chemical binding]; other site 717785006601 Switch I region; other site 717785006602 G2 box; other site 717785006603 G3 box; other site 717785006604 Switch II region; other site 717785006605 G4 box; other site 717785006606 G5 box; other site 717785006607 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 717785006608 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 717785006609 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 717785006610 potential RNA location (tRNA-U) that overlaps protein (Selenocysteine-specific translation elongation factor [Hyphomicrobium sp. MC1]) 717785006611 selenocysteine synthase; Provisional; Region: PRK04311 717785006612 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 717785006613 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785006614 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 717785006615 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 717785006616 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785006617 ligand binding site [chemical binding]; other site 717785006618 YdjC-like protein; Region: YdjC; cl01344 717785006619 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 717785006620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785006621 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 717785006622 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 717785006623 active site residue [active] 717785006624 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 717785006625 active site residue [active] 717785006626 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 717785006627 catalytic residues [active] 717785006628 dimer interface [polypeptide binding]; other site 717785006629 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785006630 Outer membrane efflux protein; Region: OEP; pfam02321 717785006631 DevC protein; Region: devC; TIGR01185 717785006632 FtsX-like permease family; Region: FtsX; pfam02687 717785006633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785006634 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785006635 Walker A/P-loop; other site 717785006636 ATP binding site [chemical binding]; other site 717785006637 Q-loop/lid; other site 717785006638 ABC transporter signature motif; other site 717785006639 Walker B; other site 717785006640 D-loop; other site 717785006641 H-loop/switch region; other site 717785006642 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 717785006643 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785006644 NAD binding site [chemical binding]; other site 717785006645 homotetramer interface [polypeptide binding]; other site 717785006646 homodimer interface [polypeptide binding]; other site 717785006647 substrate binding site [chemical binding]; other site 717785006648 active site 717785006649 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785006650 catalytic core [active] 717785006651 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 717785006652 Tetramer interface [polypeptide binding]; other site 717785006653 Active site [active] 717785006654 FMN-binding site [chemical binding]; other site 717785006655 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 717785006656 NAD+ binding site [chemical binding]; other site 717785006657 substrate binding site [chemical binding]; other site 717785006658 Zn binding site [ion binding]; other site 717785006659 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 717785006660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785006661 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 717785006662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785006663 RNA binding surface [nucleotide binding]; other site 717785006664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785006665 DoxX; Region: DoxX; cl00976 717785006666 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 717785006667 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 717785006668 TPP-binding site; other site 717785006669 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785006670 PYR/PP interface [polypeptide binding]; other site 717785006671 dimer interface [polypeptide binding]; other site 717785006672 TPP binding site [chemical binding]; other site 717785006673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785006674 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 717785006675 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 717785006676 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 717785006677 short chain dehydrogenase; Provisional; Region: PRK08278 717785006678 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 717785006679 NAD(P) binding site [chemical binding]; other site 717785006680 homodimer interface [polypeptide binding]; other site 717785006681 active site 717785006682 enoyl-CoA hydratase; Provisional; Region: PRK06023 717785006683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785006684 substrate binding site [chemical binding]; other site 717785006685 oxyanion hole (OAH) forming residues; other site 717785006686 trimer interface [polypeptide binding]; other site 717785006687 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785006688 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785006689 active site 717785006690 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 717785006691 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 717785006692 SUA5 domain; Region: SUA5; pfam03481 717785006693 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 717785006694 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 717785006695 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 717785006696 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 717785006697 LysE type translocator; Region: LysE; cl00565 717785006698 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785006699 dihydroorotase; Validated; Region: PRK09060 717785006700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 717785006701 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 717785006702 active site 717785006703 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 717785006704 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 717785006705 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 717785006706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 717785006707 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 717785006708 Quinolinate synthetase A protein; Region: NadA; cl00420 717785006709 L-aspartate oxidase; Provisional; Region: PRK07512 717785006710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785006711 domain; Region: Succ_DH_flav_C; pfam02910 717785006712 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 717785006713 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 717785006714 dimerization interface [polypeptide binding]; other site 717785006715 active site 717785006716 pyruvate phosphate dikinase; Provisional; Region: PRK09279 717785006717 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 717785006718 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 717785006719 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785006720 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 717785006721 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 717785006722 metal binding site [ion binding]; metal-binding site 717785006723 putative dimer interface [polypeptide binding]; other site 717785006724 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 717785006725 B1 nucleotide binding pocket [chemical binding]; other site 717785006726 B2 nucleotide binding pocket [chemical binding]; other site 717785006727 CAS motifs; other site 717785006728 Active site [active] 717785006729 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 717785006730 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 717785006731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785006732 NAD(P) binding site [chemical binding]; other site 717785006733 active site 717785006734 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 717785006735 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 717785006736 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 717785006737 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 717785006738 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 717785006739 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 717785006740 Mechanosensitive ion channel; Region: MS_channel; pfam00924 717785006741 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 717785006742 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 717785006743 MoaE interaction surface [polypeptide binding]; other site 717785006744 MoeB interaction surface [polypeptide binding]; other site 717785006745 thiocarboxylated glycine; other site 717785006746 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 717785006747 MoaE homodimer interface [polypeptide binding]; other site 717785006748 MoaD interaction [polypeptide binding]; other site 717785006749 active site residues [active] 717785006750 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 717785006751 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717785006752 active site 717785006753 metal binding site [ion binding]; metal-binding site 717785006754 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 717785006755 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 717785006756 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 717785006757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 717785006758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785006759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 717785006760 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 717785006761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785006762 RNA binding surface [nucleotide binding]; other site 717785006763 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 717785006764 active site 717785006765 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785006766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785006767 Carboxylesterase family; Region: COesterase; pfam00135 717785006768 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785006769 substrate binding pocket [chemical binding]; other site 717785006770 catalytic triad [active] 717785006771 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 717785006772 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 717785006773 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785006774 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785006775 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 717785006776 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 717785006777 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 717785006778 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 717785006779 Walker A motif; other site 717785006780 ATP binding site [chemical binding]; other site 717785006781 Walker B motif; other site 717785006782 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 717785006783 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 717785006784 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 717785006785 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 717785006786 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 717785006787 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 717785006788 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 717785006789 general secretion pathway protein J; Validated; Region: PRK08808 717785006790 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 717785006791 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 717785006792 General secretion pathway protein M; Region: GspM_II; pfam10741 717785006793 Carboxylesterase family; Region: COesterase; pfam00135 717785006794 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785006795 substrate binding pocket [chemical binding]; other site 717785006796 catalytic triad [active] 717785006797 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 717785006798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785006799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785006800 Carboxylesterase family; Region: COesterase; pfam00135 717785006801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785006802 substrate binding pocket [chemical binding]; other site 717785006803 catalytic triad [active] 717785006804 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 717785006805 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 717785006806 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 717785006807 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785006808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785006809 DNA-binding site [nucleotide binding]; DNA binding site 717785006810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785006811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785006812 homodimer interface [polypeptide binding]; other site 717785006813 catalytic residue [active] 717785006814 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 717785006815 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785006816 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 717785006817 putative active site [active] 717785006818 catalytic triad [active] 717785006819 putative dimer interface [polypeptide binding]; other site 717785006820 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 717785006821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785006822 FeS/SAM binding site; other site 717785006823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785006824 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 717785006825 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 717785006826 dimerization interface [polypeptide binding]; other site 717785006827 putative ATP binding site [chemical binding]; other site 717785006828 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 717785006829 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 717785006830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785006831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785006832 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785006833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785006834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785006835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785006836 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785006837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785006838 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785006839 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 717785006840 conserved cys residue [active] 717785006841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785006842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 717785006843 PAS domain S-box; Region: sensory_box; TIGR00229 717785006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785006845 putative active site [active] 717785006846 heme pocket [chemical binding]; other site 717785006847 histidine kinase; Provisional; Region: PRK13557 717785006848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785006849 putative active site [active] 717785006850 heme pocket [chemical binding]; other site 717785006851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785006852 dimer interface [polypeptide binding]; other site 717785006853 phosphorylation site [posttranslational modification] 717785006854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785006855 ATP binding site [chemical binding]; other site 717785006856 Mg2+ binding site [ion binding]; other site 717785006857 G-X-G motif; other site 717785006858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785006859 active site 717785006860 phosphorylation site [posttranslational modification] 717785006861 intermolecular recognition site; other site 717785006862 dimerization interface [polypeptide binding]; other site 717785006863 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785006864 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785006865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785006866 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 717785006867 Walker A/P-loop; other site 717785006868 ATP binding site [chemical binding]; other site 717785006869 Q-loop/lid; other site 717785006870 ABC transporter signature motif; other site 717785006871 Walker B; other site 717785006872 D-loop; other site 717785006873 H-loop/switch region; other site 717785006874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785006875 Walker A/P-loop; other site 717785006876 ATP binding site [chemical binding]; other site 717785006877 Q-loop/lid; other site 717785006878 ABC transporter signature motif; other site 717785006879 Walker B; other site 717785006880 D-loop; other site 717785006881 H-loop/switch region; other site 717785006882 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 717785006883 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 717785006884 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785006885 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785006886 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785006887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785006888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785006889 dimer interface [polypeptide binding]; other site 717785006890 conserved gate region; other site 717785006891 putative PBP binding loops; other site 717785006892 ABC-ATPase subunit interface; other site 717785006893 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785006894 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785006895 Walker A/P-loop; other site 717785006896 ATP binding site [chemical binding]; other site 717785006897 Q-loop/lid; other site 717785006898 ABC transporter signature motif; other site 717785006899 Walker B; other site 717785006900 D-loop; other site 717785006901 H-loop/switch region; other site 717785006902 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 717785006903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785006904 nickel responsive regulator; Provisional; Region: PRK04460 717785006905 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 717785006906 Creatinine amidohydrolase; Region: Creatininase; cl00618 717785006907 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13943 717785006908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785006909 S-adenosylmethionine binding site [chemical binding]; other site 717785006910 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 717785006911 Erythromycin esterase; Region: Erythro_esteras; pfam05139 717785006912 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 717785006913 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 717785006914 putative dimer interface [polypeptide binding]; other site 717785006915 BON domain; Region: BON; cl02771 717785006916 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 717785006917 BON domain; Region: BON; cl02771 717785006918 BON domain; Region: BON; cl02771 717785006919 FOG: CBS domain [General function prediction only]; Region: COG0517 717785006920 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 717785006921 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 717785006922 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 717785006923 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 717785006924 30S subunit binding site; other site 717785006925 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 717785006926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785006927 Ligand Binding Site [chemical binding]; other site 717785006928 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 717785006929 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785006930 HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 717785006931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785006932 motif II; other site 717785006933 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785006934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785006935 dimerization interface [polypeptide binding]; other site 717785006936 putative DNA binding site [nucleotide binding]; other site 717785006937 putative Zn2+ binding site [ion binding]; other site 717785006938 Low molecular weight phosphatase family; Region: LMWPc; cd00115 717785006939 Active site [active] 717785006940 Membrane transport protein; Region: Mem_trans; cl09117 717785006941 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 717785006942 catalytic residues [active] 717785006943 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785006944 Cytochrome c; Region: Cytochrom_C; cl11414 717785006945 Sel1 repeat; Region: Sel1; cl02723 717785006946 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785006947 Sel1 repeat; Region: Sel1; cl02723 717785006948 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 717785006949 carbamate kinase; Reviewed; Region: PRK09411 717785006950 putative substrate binding site [chemical binding]; other site 717785006951 nucleotide binding site [chemical binding]; other site 717785006952 nucleotide binding site [chemical binding]; other site 717785006953 homodimer interface [polypeptide binding]; other site 717785006954 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 717785006955 agmatine deiminase; Region: agmatine_aguA; TIGR03380 717785006956 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785006957 putrescine carbamoyltransferase; Provisional; Region: PRK02255 717785006958 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 717785006959 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 717785006960 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 717785006961 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 717785006962 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 717785006963 putative active site [active] 717785006964 putative metal binding site [ion binding]; other site 717785006965 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 717785006966 Domain of unknown function DUF20; Region: UPF0118; cl00465 717785006967 YceI-like domain; Region: YceI; cl01001 717785006968 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 717785006969 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 717785006970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785006971 catalytic loop [active] 717785006972 iron binding site [ion binding]; other site 717785006973 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 717785006974 FAD binding pocket [chemical binding]; other site 717785006975 FAD binding motif [chemical binding]; other site 717785006976 phosphate binding motif [ion binding]; other site 717785006977 beta-alpha-beta structure motif; other site 717785006978 NAD binding pocket [chemical binding]; other site 717785006979 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 717785006980 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 717785006981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 717785006982 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 717785006983 active site 717785006984 phosphorylation site [posttranslational modification] 717785006985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785006986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785006987 active site 717785006988 phosphorylation site [posttranslational modification] 717785006989 intermolecular recognition site; other site 717785006990 dimerization interface [polypeptide binding]; other site 717785006991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785006992 DNA binding site [nucleotide binding] 717785006993 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 717785006994 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 717785006995 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 717785006996 Ligand Binding Site [chemical binding]; other site 717785006997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785006998 dimer interface [polypeptide binding]; other site 717785006999 phosphorylation site [posttranslational modification] 717785007000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007001 ATP binding site [chemical binding]; other site 717785007002 Mg2+ binding site [ion binding]; other site 717785007003 G-X-G motif; other site 717785007004 K+-transporting ATPase, c chain; Region: KdpC; cl00944 717785007005 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 717785007006 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785007007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785007008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785007009 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 717785007010 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 717785007011 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 717785007012 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 717785007013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785007014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007015 active site 717785007016 phosphorylation site [posttranslational modification] 717785007017 intermolecular recognition site; other site 717785007018 dimerization interface [polypeptide binding]; other site 717785007019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785007020 DNA binding site [nucleotide binding] 717785007021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785007022 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785007023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785007024 dimer interface [polypeptide binding]; other site 717785007025 phosphorylation site [posttranslational modification] 717785007026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007027 ATP binding site [chemical binding]; other site 717785007028 Mg2+ binding site [ion binding]; other site 717785007029 G-X-G motif; other site 717785007030 Peptidase family M48; Region: Peptidase_M48; cl12018 717785007031 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 717785007032 Bacterial SH3 domain; Region: SH3_3; cl02551 717785007033 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785007034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785007035 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 717785007036 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 717785007037 catalytic residues [active] 717785007038 glutamine synthetase; Region: PLN02284 717785007039 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 717785007040 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785007041 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 717785007042 Glutaminase; Region: Glutaminase; cl00907 717785007043 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785007044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007045 NAD(P) binding site [chemical binding]; other site 717785007046 active site 717785007047 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785007048 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 717785007049 conserved cys residue [active] 717785007050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785007051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 717785007052 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 717785007053 membrane ATPase/protein kinase; Provisional; Region: PRK09435 717785007054 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 717785007055 Walker A; other site 717785007056 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 717785007057 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007058 ligand binding site [chemical binding]; other site 717785007059 flexible hinge region; other site 717785007060 Bacterial sugar transferase; Region: Bac_transf; cl00939 717785007061 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 717785007062 transcriptional activator RfaH; Region: RfaH; TIGR01955 717785007063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007064 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 717785007065 putative acyl transferase; Provisional; Region: PRK10502 717785007066 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 717785007067 putative trimer interface [polypeptide binding]; other site 717785007068 putative active site [active] 717785007069 putative substrate binding site [chemical binding]; other site 717785007070 putative CoA binding site [chemical binding]; other site 717785007071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007072 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 717785007073 putative ADP-binding pocket [chemical binding]; other site 717785007074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785007075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 717785007077 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007078 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 717785007079 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 717785007080 putative ADP-binding pocket [chemical binding]; other site 717785007081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007082 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 717785007083 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785007084 Chain length determinant protein; Region: Wzz; cl01623 717785007085 Chain length determinant protein; Region: Wzz; cl01623 717785007086 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 717785007087 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 717785007088 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 717785007089 SLBB domain; Region: SLBB; pfam10531 717785007090 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 717785007091 O-Antigen ligase; Region: Wzy_C; cl04850 717785007092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785007093 metal binding site [ion binding]; metal-binding site 717785007094 active site 717785007095 I-site; other site 717785007096 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785007097 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 717785007098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785007099 DNA binding residues [nucleotide binding] 717785007100 dimerization interface [polypeptide binding]; other site 717785007101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007102 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785007103 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 717785007104 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 717785007105 Autotransporter beta-domain; Region: Autotransporter; cl02365 717785007106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785007107 TPR motif; other site 717785007108 binding surface 717785007109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785007110 active site 717785007111 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 717785007112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007113 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 717785007114 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 717785007115 extended (e) SDRs; Region: SDR_e; cd08946 717785007116 NAD(P) binding site [chemical binding]; other site 717785007117 active site 717785007118 substrate binding site [chemical binding]; other site 717785007119 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 717785007120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007121 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 717785007122 putative dimerization interface [polypeptide binding]; other site 717785007123 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 717785007124 Cation efflux family; Region: Cation_efflux; cl00316 717785007125 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717785007126 envelope glycoprotein I; Provisional; Region: PHA03291 717785007127 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 717785007128 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 717785007129 active site 717785007130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 717785007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007132 Response regulator receiver domain; Region: Response_reg; pfam00072 717785007133 active site 717785007134 phosphorylation site [posttranslational modification] 717785007135 intermolecular recognition site; other site 717785007136 dimerization interface [polypeptide binding]; other site 717785007137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785007138 DNA-binding site [nucleotide binding]; DNA binding site 717785007139 RNA-binding motif; other site 717785007140 Protein of unknown function (DUF519); Region: DUF519; cl04492 717785007141 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 717785007142 GTP-binding protein Der; Reviewed; Region: PRK00093 717785007143 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 717785007144 G1 box; other site 717785007145 GTP/Mg2+ binding site [chemical binding]; other site 717785007146 Switch I region; other site 717785007147 G2 box; other site 717785007148 Switch II region; other site 717785007149 G3 box; other site 717785007150 G4 box; other site 717785007151 G5 box; other site 717785007152 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 717785007153 G1 box; other site 717785007154 GTP/Mg2+ binding site [chemical binding]; other site 717785007155 Switch I region; other site 717785007156 G2 box; other site 717785007157 G3 box; other site 717785007158 Switch II region; other site 717785007159 G4 box; other site 717785007160 G5 box; other site 717785007161 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785007162 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 717785007164 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 717785007165 oligomerization interface [polypeptide binding]; other site 717785007166 active site 717785007167 metal binding site [ion binding]; metal-binding site 717785007168 hypothetical protein; Provisional; Region: PRK12472 717785007169 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 717785007170 hypothetical protein; Provisional; Region: PRK06132 717785007171 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 717785007172 catalytic site [active] 717785007173 Asp-box motif; other site 717785007174 NnrU protein; Region: NnrU; cl01697 717785007175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007177 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 717785007178 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 717785007179 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 717785007180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007181 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785007182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007183 peptide chain release factor 2; Provisional; Region: PRK07342 717785007184 RF-1 domain; Region: RF-1; cl02875 717785007185 RF-1 domain; Region: RF-1; cl02875 717785007186 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 717785007187 Transglycosylase; Region: Transgly; cl07896 717785007188 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 717785007189 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 717785007190 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 717785007191 active site 717785007192 metal binding site [ion binding]; metal-binding site 717785007193 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 717785007194 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 717785007195 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 717785007196 Peptidase family M48; Region: Peptidase_M48; cl12018 717785007197 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 717785007198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785007199 binding surface 717785007200 TPR motif; other site 717785007201 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 717785007202 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 717785007203 catalytic residues [active] 717785007204 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 717785007205 trimer interface [polypeptide binding]; other site 717785007206 active site 717785007207 dimer interface [polypeptide binding]; other site 717785007208 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 717785007209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 717785007210 carboxyltransferase (CT) interaction site; other site 717785007211 biotinylation site [posttranslational modification]; other site 717785007212 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 717785007213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 717785007214 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785007215 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 717785007216 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 717785007217 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 717785007218 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 717785007219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007220 D-galactonate transporter; Region: 2A0114; TIGR00893 717785007221 putative substrate translocation pore; other site 717785007222 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 717785007223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007227 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 717785007228 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785007229 NADP binding site [chemical binding]; other site 717785007230 active site 717785007231 steroid binding site; other site 717785007232 GMP synthase; Reviewed; Region: guaA; PRK00074 717785007233 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 717785007234 AMP/PPi binding site [chemical binding]; other site 717785007235 candidate oxyanion hole; other site 717785007236 catalytic triad [active] 717785007237 potential glutamine specificity residues [chemical binding]; other site 717785007238 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 717785007239 ATP Binding subdomain [chemical binding]; other site 717785007240 Ligand Binding sites [chemical binding]; other site 717785007241 Dimerization subdomain; other site 717785007242 TspO/MBR family; Region: TspO_MBR; cl01379 717785007243 SET domain; Region: SET; cl02566 717785007244 SET domain; Region: SET; cl02566 717785007245 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 717785007246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007247 MAPEG family; Region: MAPEG; cl09190 717785007248 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 717785007249 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 717785007250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 717785007251 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 717785007252 active site 717785007253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785007254 S-adenosylmethionine binding site [chemical binding]; other site 717785007255 exopolyphosphatase; Region: exo_poly_only; TIGR03706 717785007256 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 717785007257 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 717785007258 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785007259 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785007260 catalytic residues [active] 717785007261 catalytic nucleophile [active] 717785007262 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785007263 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785007264 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785007265 Synaptic Site I dimer interface [polypeptide binding]; other site 717785007266 DNA binding site [nucleotide binding] 717785007267 Recombinase; Region: Recombinase; pfam07508 717785007268 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785007269 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785007270 Transposase domain (DUF772); Region: DUF772; cl12084 717785007271 Transposase domain (DUF772); Region: DUF772; cl12084 717785007272 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785007273 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785007274 Walker A/P-loop; other site 717785007275 ATP binding site [chemical binding]; other site 717785007276 Q-loop/lid; other site 717785007277 ABC transporter signature motif; other site 717785007278 Walker B; other site 717785007279 D-loop; other site 717785007280 H-loop/switch region; other site 717785007281 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 717785007282 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 717785007283 FtsX-like permease family; Region: FtsX; pfam02687 717785007284 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785007285 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785007286 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785007287 Ligand Binding Site [chemical binding]; other site 717785007288 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 717785007289 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 717785007290 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785007291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785007292 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785007293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785007294 DNA binding site [nucleotide binding] 717785007295 Predicted integral membrane protein [Function unknown]; Region: COG5616 717785007296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785007297 TPR motif; other site 717785007298 binding surface 717785007299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785007300 binding surface 717785007301 TPR motif; other site 717785007302 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 717785007303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007304 NAD(P) binding site [chemical binding]; other site 717785007305 active site 717785007306 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785007307 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785007308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785007309 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007310 ligand binding site [chemical binding]; other site 717785007311 flexible hinge region; other site 717785007312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007313 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 717785007314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007315 ligand binding site [chemical binding]; other site 717785007316 flexible hinge region; other site 717785007317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007318 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 717785007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007320 putative substrate translocation pore; other site 717785007321 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 717785007322 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 717785007323 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 717785007324 [4Fe-4S] binding site [ion binding]; other site 717785007325 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 717785007326 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 717785007327 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 717785007328 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 717785007329 molybdopterin cofactor binding site; other site 717785007330 nitrate reductase, beta subunit; Region: narH; TIGR01660 717785007331 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 717785007332 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 717785007333 PPIC-type PPIASE domain; Region: Rotamase; cl08278 717785007334 Copper resistance protein D; Region: CopD; cl00563 717785007335 NnrS protein; Region: NnrS; cl01258 717785007336 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785007337 Transposase domain (DUF772); Region: DUF772; cl12084 717785007338 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 717785007339 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785007340 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 717785007341 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785007342 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 717785007343 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 717785007344 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 717785007345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007346 Response regulator receiver domain; Region: Response_reg; pfam00072 717785007347 active site 717785007348 phosphorylation site [posttranslational modification] 717785007349 intermolecular recognition site; other site 717785007350 dimerization interface [polypeptide binding]; other site 717785007351 H-NS histone family; Region: Histone_HNS; pfam00816 717785007352 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 717785007353 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 717785007354 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 717785007355 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717785007356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785007357 ligand binding site [chemical binding]; other site 717785007358 flexible hinge region; other site 717785007359 Sulfatase; Region: Sulfatase; cl10460 717785007360 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007361 Integrase core domain; Region: rve; cl01316 717785007362 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007363 RNA polymerase sigma factor; Provisional; Region: PRK12547 717785007364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785007365 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 717785007366 DNA binding residues [nucleotide binding] 717785007367 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785007368 classical (c) SDRs; Region: SDR_c; cd05233 717785007369 NAD(P) binding site [chemical binding]; other site 717785007370 active site 717785007371 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785007372 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 717785007373 putative NADP binding site [chemical binding]; other site 717785007374 putative substrate binding site [chemical binding]; other site 717785007375 active site 717785007376 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 717785007377 B12 binding site [chemical binding]; other site 717785007378 Radical SAM; Region: Elp3; smart00729 717785007379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 717785007380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785007381 putative active site [active] 717785007382 heme pocket [chemical binding]; other site 717785007383 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785007384 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 717785007385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785007386 S-adenosylmethionine binding site [chemical binding]; other site 717785007387 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 717785007388 CheB methylesterase; Region: CheB_methylest; pfam01339 717785007389 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 717785007390 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785007391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007392 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 717785007393 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 717785007394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785007395 dimer interface [polypeptide binding]; other site 717785007396 phosphorylation site [posttranslational modification] 717785007397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007398 ATP binding site [chemical binding]; other site 717785007399 Mg2+ binding site [ion binding]; other site 717785007400 G-X-G motif; other site 717785007401 Response regulator receiver domain; Region: Response_reg; pfam00072 717785007402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007403 active site 717785007404 phosphorylation site [posttranslational modification] 717785007405 intermolecular recognition site; other site 717785007406 dimerization interface [polypeptide binding]; other site 717785007407 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 717785007408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007409 active site 717785007410 phosphorylation site [posttranslational modification] 717785007411 intermolecular recognition site; other site 717785007412 dimerization interface [polypeptide binding]; other site 717785007413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785007414 DNA binding residues [nucleotide binding] 717785007415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785007416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 717785007417 active site 717785007418 phosphorylation site [posttranslational modification] 717785007419 intermolecular recognition site; other site 717785007420 dimerization interface [polypeptide binding]; other site 717785007421 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 717785007422 Domain of unknown function DUF20; Region: UPF0118; cl00465 717785007423 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 717785007424 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785007425 DNA-binding site [nucleotide binding]; DNA binding site 717785007426 RNA-binding motif; other site 717785007427 Haemolysin-III related; Region: HlyIII; cl03831 717785007428 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785007429 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785007430 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785007431 Protein required for attachment to host cells; Region: Host_attach; cl02398 717785007432 Low affinity iron permease; Region: Iron_permease; cl12096 717785007433 Low affinity iron permease; Region: Iron_permease; cl12096 717785007434 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007435 Integrase core domain; Region: rve; cl01316 717785007436 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007437 Protein required for attachment to host cells; Region: Host_attach; cl02398 717785007438 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785007439 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785007440 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007441 Integrase core domain; Region: rve; cl01316 717785007442 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 717785007443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785007444 Terminase-like family; Region: Terminase_6; pfam03237 717785007445 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785007446 ParB-like nuclease domain; Region: ParBc; cl02129 717785007447 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785007448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007449 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785007450 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785007451 catalytic residues [active] 717785007452 catalytic nucleophile [active] 717785007453 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785007454 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785007455 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785007456 Synaptic Site I dimer interface [polypeptide binding]; other site 717785007457 DNA binding site [nucleotide binding] 717785007458 Recombinase; Region: Recombinase; pfam07508 717785007459 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785007460 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785007461 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785007462 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 717785007463 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 717785007464 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 717785007465 putative active site [active] 717785007466 putative metal-binding site [ion binding]; other site 717785007467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 717785007468 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 717785007469 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785007470 active site 717785007471 ATP binding site [chemical binding]; other site 717785007472 substrate binding site [chemical binding]; other site 717785007473 activation loop (A-loop); other site 717785007474 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 717785007475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 717785007476 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 717785007477 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 717785007478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785007479 Walker A motif; other site 717785007480 ATP binding site [chemical binding]; other site 717785007481 Walker B motif; other site 717785007482 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785007483 enoyl-CoA hydratase; Provisional; Region: PRK07327 717785007484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785007485 substrate binding site [chemical binding]; other site 717785007486 oxyanion hole (OAH) forming residues; other site 717785007487 trimer interface [polypeptide binding]; other site 717785007488 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 717785007489 Phenylacetic acid degradation B; Region: PaaB; cl01371 717785007490 Domain of unknown function DUF59; Region: DUF59; cl00941 717785007491 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 717785007492 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 717785007493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785007496 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785007497 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785007498 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 717785007499 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 717785007500 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 717785007501 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 717785007502 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 717785007503 Flavoprotein; Region: Flavoprotein; cl08021 717785007504 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 717785007505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 717785007506 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 717785007507 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 717785007508 Walker A/P-loop; other site 717785007509 ATP binding site [chemical binding]; other site 717785007510 Q-loop/lid; other site 717785007511 ABC transporter signature motif; other site 717785007512 Walker B; other site 717785007513 D-loop; other site 717785007514 H-loop/switch region; other site 717785007515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785007516 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 717785007517 Walker A/P-loop; other site 717785007518 ATP binding site [chemical binding]; other site 717785007519 Q-loop/lid; other site 717785007520 ABC transporter signature motif; other site 717785007521 Walker B; other site 717785007522 D-loop; other site 717785007523 H-loop/switch region; other site 717785007524 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785007525 TM-ABC transporter signature motif; other site 717785007526 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785007527 TM-ABC transporter signature motif; other site 717785007528 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 717785007529 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785007530 ligand binding site [chemical binding]; other site 717785007531 glyoxylate reductase; Reviewed; Region: PRK13243 717785007532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007533 Rrf2 family protein; Region: rrf2_super; TIGR00738 717785007534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007535 enoyl-CoA hydratase; Provisional; Region: PRK08290 717785007536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 717785007537 substrate binding site [chemical binding]; other site 717785007538 oxyanion hole (OAH) forming residues; other site 717785007539 trimer interface [polypeptide binding]; other site 717785007540 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785007541 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785007542 active site 717785007543 non-prolyl cis peptide bond; other site 717785007544 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785007545 active site 717785007546 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785007547 dimer interface [polypeptide binding]; other site 717785007548 non-prolyl cis peptide bond; other site 717785007549 insertion regions; other site 717785007550 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 717785007551 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 717785007552 dimer interface [polypeptide binding]; other site 717785007553 catalytic residue [active] 717785007554 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785007555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007556 putative substrate translocation pore; other site 717785007557 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785007558 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 717785007559 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785007561 substrate binding pocket [chemical binding]; other site 717785007562 membrane-bound complex binding site; other site 717785007563 hinge residues; other site 717785007564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 717785007565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785007566 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007567 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007568 Walker A/P-loop; other site 717785007569 ATP binding site [chemical binding]; other site 717785007570 Q-loop/lid; other site 717785007571 ABC transporter signature motif; other site 717785007572 Walker B; other site 717785007573 D-loop; other site 717785007574 H-loop/switch region; other site 717785007575 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785007576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785007577 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 717785007578 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 717785007579 active site 717785007580 non-prolyl cis peptide bond; other site 717785007581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785007582 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 717785007583 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717785007584 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 717785007585 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007586 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007587 Walker A/P-loop; other site 717785007588 ATP binding site [chemical binding]; other site 717785007589 Q-loop/lid; other site 717785007590 ABC transporter signature motif; other site 717785007591 Walker B; other site 717785007592 D-loop; other site 717785007593 H-loop/switch region; other site 717785007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007595 dimer interface [polypeptide binding]; other site 717785007596 conserved gate region; other site 717785007597 putative PBP binding loops; other site 717785007598 ABC-ATPase subunit interface; other site 717785007599 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785007601 substrate binding pocket [chemical binding]; other site 717785007602 membrane-bound complex binding site; other site 717785007603 hinge residues; other site 717785007604 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 717785007605 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785007607 substrate binding pocket [chemical binding]; other site 717785007608 membrane-bound complex binding site; other site 717785007609 hinge residues; other site 717785007610 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785007612 substrate binding pocket [chemical binding]; other site 717785007613 membrane-bound complex binding site; other site 717785007614 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 717785007615 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785007616 active site 717785007617 dimer interface [polypeptide binding]; other site 717785007618 non-prolyl cis peptide bond; other site 717785007619 insertion regions; other site 717785007620 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785007621 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785007622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007623 dimer interface [polypeptide binding]; other site 717785007624 conserved gate region; other site 717785007625 putative PBP binding loops; other site 717785007626 ABC-ATPase subunit interface; other site 717785007627 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007628 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007629 Walker A/P-loop; other site 717785007630 ATP binding site [chemical binding]; other site 717785007631 Q-loop/lid; other site 717785007632 ABC transporter signature motif; other site 717785007633 Walker B; other site 717785007634 D-loop; other site 717785007635 H-loop/switch region; other site 717785007636 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785007637 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 717785007638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007639 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 717785007640 substrate binding site [chemical binding]; other site 717785007641 dimerization interface [polypeptide binding]; other site 717785007642 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 717785007643 Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]; Region: COG1245 717785007644 putative oxidoreductase; Provisional; Region: PRK08275 717785007645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785007646 domain; Region: Succ_DH_flav_C; pfam02910 717785007647 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007648 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007649 Walker A/P-loop; other site 717785007650 ATP binding site [chemical binding]; other site 717785007651 Q-loop/lid; other site 717785007652 ABC transporter signature motif; other site 717785007653 Walker B; other site 717785007654 D-loop; other site 717785007655 H-loop/switch region; other site 717785007656 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007658 putative PBP binding loops; other site 717785007659 dimer interface [polypeptide binding]; other site 717785007660 ABC-ATPase subunit interface; other site 717785007661 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785007663 ParB-like nuclease domain; Region: ParBc; cl02129 717785007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785007666 Terminase-like family; Region: Terminase_6; pfam03237 717785007667 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785007668 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 717785007669 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 717785007670 catalytic residues [active] 717785007671 catalytic nucleophile [active] 717785007672 Presynaptic Site I dimer interface [polypeptide binding]; other site 717785007673 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 717785007674 Synaptic Flat tetramer interface [polypeptide binding]; other site 717785007675 Synaptic Site I dimer interface [polypeptide binding]; other site 717785007676 DNA binding site [nucleotide binding] 717785007677 Recombinase; Region: Recombinase; pfam07508 717785007678 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 717785007679 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 717785007680 Tir chaperone protein (CesT); Region: CesT; cl08444 717785007681 sulfate transport protein; Provisional; Region: cysT; CHL00187 717785007682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007683 dimer interface [polypeptide binding]; other site 717785007684 conserved gate region; other site 717785007685 putative PBP binding loops; other site 717785007686 ABC-ATPase subunit interface; other site 717785007687 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785007688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007689 dimer interface [polypeptide binding]; other site 717785007690 conserved gate region; other site 717785007691 putative PBP binding loops; other site 717785007692 ABC-ATPase subunit interface; other site 717785007693 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 717785007694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785007695 Walker A/P-loop; other site 717785007696 ATP binding site [chemical binding]; other site 717785007697 Q-loop/lid; other site 717785007698 ABC transporter signature motif; other site 717785007699 Walker B; other site 717785007700 D-loop; other site 717785007701 H-loop/switch region; other site 717785007702 TOBE domain; Region: TOBE_2; cl01440 717785007703 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785007704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785007705 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 717785007706 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785007707 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785007708 [2Fe-2S] cluster binding site [ion binding]; other site 717785007709 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 717785007710 putative alpha subunit interface [polypeptide binding]; other site 717785007711 putative active site [active] 717785007712 putative substrate binding site [chemical binding]; other site 717785007713 Fe binding site [ion binding]; other site 717785007714 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785007715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785007716 non-specific DNA binding site [nucleotide binding]; other site 717785007717 salt bridge; other site 717785007718 sequence-specific DNA binding site [nucleotide binding]; other site 717785007719 Cupin domain; Region: Cupin_2; cl09118 717785007720 transcriptional regulator BetI; Validated; Region: PRK00767 717785007721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007722 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 717785007723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785007724 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785007725 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 717785007726 FMN-binding pocket [chemical binding]; other site 717785007727 flavin binding motif; other site 717785007728 phosphate binding motif [ion binding]; other site 717785007729 beta-alpha-beta structure motif; other site 717785007730 NAD binding pocket [chemical binding]; other site 717785007731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785007732 catalytic loop [active] 717785007733 iron binding site [ion binding]; other site 717785007734 transcriptional regulator BetI; Validated; Region: PRK00767 717785007735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007736 CoA-transferase family III; Region: CoA_transf_3; cl00778 717785007737 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 717785007738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785007739 FAD binding site [chemical binding]; other site 717785007740 substrate binding pocket [chemical binding]; other site 717785007741 catalytic base [active] 717785007742 Tir chaperone protein (CesT); Region: CesT; cl08444 717785007743 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 717785007744 Integrase core domain; Region: rve; cl01316 717785007745 Autotransporter beta-domain; Region: Autotransporter; cl02365 717785007746 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 717785007747 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 717785007748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785007749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785007750 dimerization interface [polypeptide binding]; other site 717785007751 citrate-proton symporter; Provisional; Region: PRK15075 717785007752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007753 putative substrate translocation pore; other site 717785007754 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785007755 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 717785007756 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 717785007757 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 717785007758 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 717785007759 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785007760 active site 717785007761 ATP binding site [chemical binding]; other site 717785007762 substrate binding site [chemical binding]; other site 717785007763 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 717785007764 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 717785007765 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 717785007766 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 717785007767 FliP family; Region: FliP; cl00593 717785007768 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 717785007769 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 717785007770 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 717785007771 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 717785007772 type III secretion system ATPase; Provisional; Region: PRK06936 717785007773 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 717785007774 Walker A motif/ATP binding site; other site 717785007775 Walker B motif; other site 717785007776 Tir chaperone protein (CesT); Region: CesT; cl08444 717785007777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 717785007778 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 717785007779 Cache domain; Region: Cache_1; pfam02743 717785007780 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 717785007781 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 717785007782 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 717785007783 anti sigma factor interaction site; other site 717785007784 regulatory phosphorylation site [posttranslational modification]; other site 717785007785 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 717785007786 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 717785007787 Uncharacterized conserved protein [Function unknown]; Region: COG3535 717785007788 Protein of unknown function (DUF917); Region: DUF917; pfam06032 717785007789 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 717785007790 Tir chaperone protein (CesT); Region: CesT; cl08444 717785007791 Tir chaperone protein (CesT); Region: CesT; cl08444 717785007792 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 717785007793 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 717785007794 FHIPEP family; Region: FHIPEP; pfam00771 717785007795 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 717785007796 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 717785007797 HrpJ-like domain; Region: HrpJ; pfam07201 717785007798 TyeA; Region: TyeA; cl07611 717785007799 Flagellar assembly protein FliH; Region: FliH; pfam02108 717785007800 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 717785007801 Type III secretion needle MxiH like; Region: MxiH; cl09641 717785007802 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 717785007803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785007804 binding surface 717785007805 TPR motif; other site 717785007806 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 717785007807 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 717785007808 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785007809 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785007810 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 717785007811 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 717785007812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785007813 Terminase-like family; Region: Terminase_6; pfam03237 717785007814 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785007815 ParB-like nuclease domain; Region: ParBc; cl02129 717785007816 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 717785007817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007818 ParB-like partition proteins; Region: parB_part; TIGR00180 717785007819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785007820 hypothetical protein; Provisional; Region: PRK13560 717785007821 putative active site [active] 717785007822 heme pocket [chemical binding]; other site 717785007823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785007824 Histidine kinase; Region: HisKA_2; cl06527 717785007825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007826 ATP binding site [chemical binding]; other site 717785007827 Mg2+ binding site [ion binding]; other site 717785007828 G-X-G motif; other site 717785007829 Response regulator receiver domain; Region: Response_reg; pfam00072 717785007830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007831 active site 717785007832 phosphorylation site [posttranslational modification] 717785007833 intermolecular recognition site; other site 717785007834 dimerization interface [polypeptide binding]; other site 717785007835 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785007836 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785007837 GAF domain; Region: GAF; cl00853 717785007838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785007839 Histidine kinase; Region: HisKA_2; cl06527 717785007840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007841 ATP binding site [chemical binding]; other site 717785007842 Mg2+ binding site [ion binding]; other site 717785007843 G-X-G motif; other site 717785007844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 717785007845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007846 putative substrate translocation pore; other site 717785007847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785007848 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785007849 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 717785007850 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785007851 catalytic loop [active] 717785007852 iron binding site [ion binding]; other site 717785007853 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 717785007854 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 717785007855 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 717785007856 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 717785007857 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 717785007858 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 717785007859 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 717785007860 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 717785007861 classical (c) SDRs; Region: SDR_c; cd05233 717785007862 NAD(P) binding site [chemical binding]; other site 717785007863 active site 717785007864 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 717785007865 active site 717785007866 DNA polymerase IV; Validated; Region: PRK02406 717785007867 DNA binding site [nucleotide binding] 717785007868 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 717785007869 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 717785007870 FMN-binding pocket [chemical binding]; other site 717785007871 flavin binding motif; other site 717785007872 phosphate binding motif [ion binding]; other site 717785007873 beta-alpha-beta structure motif; other site 717785007874 NAD binding pocket [chemical binding]; other site 717785007875 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785007876 catalytic loop [active] 717785007877 iron binding site [ion binding]; other site 717785007878 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 717785007879 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 717785007880 [2Fe-2S] cluster binding site [ion binding]; other site 717785007881 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 717785007882 hydrophobic ligand binding site; other site 717785007883 Transcriptional regulators [Transcription]; Region: GntR; COG1802 717785007884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785007885 DNA-binding site [nucleotide binding]; DNA binding site 717785007886 FCD domain; Region: FCD; cl11656 717785007887 Isochorismatase family; Region: Isochorismatase; pfam00857 717785007888 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785007889 catalytic triad [active] 717785007890 conserved cis-peptide bond; other site 717785007891 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785007892 Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150 717785007893 NAD(P) binding site [chemical binding]; other site 717785007894 catalytic residues [active] 717785007895 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 717785007896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785007897 catalytic residue [active] 717785007898 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 717785007899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785007900 DNA-binding site [nucleotide binding]; DNA binding site 717785007901 UTRA domain; Region: UTRA; cl06649 717785007902 acetylornithine deacetylase; Validated; Region: PRK06915 717785007903 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 717785007904 metal binding site [ion binding]; metal-binding site 717785007905 dimer interface [polypeptide binding]; other site 717785007906 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 717785007907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785007908 Coenzyme A transferase; Region: CoA_trans; cl00773 717785007909 Coenzyme A transferase; Region: CoA_trans; cl00773 717785007910 FO synthase; Reviewed; Region: fbiC; PRK09234 717785007911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785007912 FeS/SAM binding site; other site 717785007913 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 717785007914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 717785007915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785007916 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 717785007917 dimer interface [polypeptide binding]; other site 717785007918 substrate binding site [chemical binding]; other site 717785007919 phosphate binding site [ion binding]; other site 717785007920 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 717785007921 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 717785007922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785007923 choline dehydrogenase; Validated; Region: PRK02106 717785007924 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 717785007925 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785007926 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785007927 Walker A/P-loop; other site 717785007928 ATP binding site [chemical binding]; other site 717785007929 Q-loop/lid; other site 717785007930 ABC transporter signature motif; other site 717785007931 Walker B; other site 717785007932 D-loop; other site 717785007933 H-loop/switch region; other site 717785007934 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 717785007935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785007936 dimer interface [polypeptide binding]; other site 717785007937 conserved gate region; other site 717785007938 putative PBP binding loops; other site 717785007939 ABC-ATPase subunit interface; other site 717785007940 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 717785007941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785007942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 717785007943 Terminase-like family; Region: Terminase_6; pfam03237 717785007944 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 717785007945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785007946 ParB-like nuclease domain; Region: ParBc; cl02129 717785007947 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 717785007948 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785007949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785007950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785007951 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 717785007952 dimer interface [polypeptide binding]; other site 717785007953 [2Fe-2S] cluster binding site [ion binding]; other site 717785007954 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785007955 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785007956 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 717785007957 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 717785007958 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 717785007959 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 717785007960 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785007961 multimer interface [polypeptide binding]; other site 717785007962 active site 717785007963 catalytic triad [active] 717785007964 dimer interface [polypeptide binding]; other site 717785007965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 717785007966 metal ion-dependent adhesion site (MIDAS); other site 717785007967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785007968 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 717785007969 Walker A motif; other site 717785007970 ATP binding site [chemical binding]; other site 717785007971 Walker B motif; other site 717785007972 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 717785007973 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 717785007974 ANTAR domain; Region: ANTAR; pfam03861 717785007975 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 717785007976 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 717785007977 ligand binding site [chemical binding]; other site 717785007978 regulator interaction site; other site 717785007979 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 717785007980 putative active site [active] 717785007981 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785007982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785007983 active site 717785007984 phosphorylation site [posttranslational modification] 717785007985 intermolecular recognition site; other site 717785007986 dimerization interface [polypeptide binding]; other site 717785007987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785007988 DNA binding site [nucleotide binding] 717785007989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785007990 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785007991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785007992 ATP binding site [chemical binding]; other site 717785007993 Mg2+ binding site [ion binding]; other site 717785007994 G-X-G motif; other site 717785007995 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785007996 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785007997 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785007998 N-terminal plug; other site 717785007999 ligand-binding site [chemical binding]; other site 717785008000 Cupin domain; Region: Cupin_2; cl09118 717785008001 Flavin Reductases; Region: FlaRed; cl00801 717785008002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785008003 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 717785008004 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 717785008005 active site 717785008006 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 717785008007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785008008 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785008009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785008010 non-specific DNA binding site [nucleotide binding]; other site 717785008011 salt bridge; other site 717785008012 sequence-specific DNA binding site [nucleotide binding]; other site 717785008013 Cupin domain; Region: Cupin_2; cl09118 717785008014 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785008015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785008016 non-specific DNA binding site [nucleotide binding]; other site 717785008017 salt bridge; other site 717785008018 sequence-specific DNA binding site [nucleotide binding]; other site 717785008019 Cupin domain; Region: Cupin_2; cl09118 717785008020 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008021 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785008022 NAD(P) binding site [chemical binding]; other site 717785008023 catalytic residues [active] 717785008024 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785008025 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785008026 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785008027 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785008028 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785008029 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785008030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008031 dimer interface [polypeptide binding]; other site 717785008032 conserved gate region; other site 717785008033 putative PBP binding loops; other site 717785008034 ABC-ATPase subunit interface; other site 717785008035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 717785008036 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785008037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008038 Walker A/P-loop; other site 717785008039 ATP binding site [chemical binding]; other site 717785008040 Q-loop/lid; other site 717785008041 ABC transporter signature motif; other site 717785008042 Walker B; other site 717785008043 D-loop; other site 717785008044 H-loop/switch region; other site 717785008045 TOBE domain; Region: TOBE_2; cl01440 717785008046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008047 Sodium:solute symporter family; Region: SSF; cl00456 717785008048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785008049 D-galactonate transporter; Region: 2A0114; TIGR00893 717785008050 putative substrate translocation pore; other site 717785008051 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785008052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008054 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 717785008055 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785008056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785008057 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 717785008058 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 717785008059 active site 717785008060 Flavin Reductases; Region: FlaRed; cl00801 717785008061 EthD protein; Region: EthD; cl06234 717785008062 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 717785008063 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008064 NAD(P) binding site [chemical binding]; other site 717785008065 catalytic residues [active] 717785008066 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785008067 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785008068 Trp docking motif; other site 717785008069 'Velcro' closure; other site 717785008070 active site 717785008071 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 717785008072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 717785008073 substrate binding pocket [chemical binding]; other site 717785008074 membrane-bound complex binding site; other site 717785008075 hinge residues; other site 717785008076 Cytochrome c; Region: Cytochrom_C; cl11414 717785008077 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 717785008078 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785008079 Cytochrome c; Region: Cytochrom_C; cl11414 717785008080 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785008081 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 717785008082 D-pathway; other site 717785008083 Putative ubiquinol binding site [chemical binding]; other site 717785008084 Low-spin heme (heme b) binding site [chemical binding]; other site 717785008085 Putative water exit pathway; other site 717785008086 Binuclear center (heme o3/CuB) [ion binding]; other site 717785008087 K-pathway; other site 717785008088 Putative proton exit pathway; other site 717785008089 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the...; Region: Heme_Cu_Oxidase_III_2; cd02865 717785008090 Subunit I/III interface [polypeptide binding]; other site 717785008091 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 717785008092 Cytochrome c; Region: Cytochrom_C; cl11414 717785008093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 717785008094 Sulfatase; Region: Sulfatase; cl10460 717785008095 Domain of unknown function DUF; Region: DUF202; cl09954 717785008096 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 717785008097 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 717785008098 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 717785008099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785008100 putative oxidoreductase FixC; Provisional; Region: PRK10157 717785008101 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 717785008102 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 717785008103 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785008104 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 717785008105 Ligand binding site [chemical binding]; other site 717785008106 Nitrogen fixation protein NifW; Region: NifW; cl03935 717785008107 serine O-acetyltransferase; Region: cysE; TIGR01172 717785008108 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 717785008109 trimer interface [polypeptide binding]; other site 717785008110 active site 717785008111 substrate binding site [chemical binding]; other site 717785008112 CoA binding site [chemical binding]; other site 717785008113 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 717785008114 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 717785008115 active site 717785008116 catalytic residues [active] 717785008117 metal binding site [ion binding]; metal-binding site 717785008118 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785008119 metal binding site 2 [ion binding]; metal-binding site 717785008120 putative DNA binding helix; other site 717785008121 metal binding site 1 [ion binding]; metal-binding site 717785008122 dimer interface [polypeptide binding]; other site 717785008123 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 717785008124 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 717785008125 Nucleotide-binding sites [chemical binding]; other site 717785008126 Walker A motif; other site 717785008127 Switch I region of nucleotide binding site; other site 717785008128 Fe4S4 binding sites [ion binding]; other site 717785008129 Switch II region of nucleotide binding site; other site 717785008130 Response regulator receiver domain; Region: Response_reg; pfam00072 717785008131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785008132 active site 717785008133 phosphorylation site [posttranslational modification] 717785008134 intermolecular recognition site; other site 717785008135 dimerization interface [polypeptide binding]; other site 717785008136 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that...; Region: ArsC_15kD; cd03033 717785008137 putative catalytic residues [active] 717785008138 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 717785008139 NADPH bind site [chemical binding]; other site 717785008140 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 717785008141 putative FMN binding site [chemical binding]; other site 717785008142 NADPH bind site [chemical binding]; other site 717785008143 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 717785008144 active site residue [active] 717785008145 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785008146 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785008147 Domain of unknown function DUF59; Region: DUF59; cl00941 717785008148 BolA-like protein; Region: BolA; cl00386 717785008149 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 717785008150 putative GSH binding site [chemical binding]; other site 717785008151 catalytic residues [active] 717785008152 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 717785008153 dimer interface [polypeptide binding]; other site 717785008154 [2Fe-2S] cluster binding site [ion binding]; other site 717785008155 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 717785008156 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 717785008157 apolar tunnel; other site 717785008158 heme binding site [chemical binding]; other site 717785008159 dimerization interface [polypeptide binding]; other site 717785008160 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 717785008161 iron-sulfur cluster [ion binding]; other site 717785008162 [2Fe-2S] cluster binding site [ion binding]; other site 717785008163 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 717785008164 catalytic loop [active] 717785008165 iron binding site [ion binding]; other site 717785008166 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 717785008167 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 717785008168 inhibitor-cofactor binding pocket; inhibition site 717785008169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008170 catalytic residue [active] 717785008171 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 717785008172 NifZ domain; Region: NifZ; pfam04319 717785008173 NifZ domain; Region: NifZ; pfam04319 717785008174 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 717785008175 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 717785008176 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 717785008177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785008178 FeS/SAM binding site; other site 717785008179 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 717785008180 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 717785008181 NifT/FixU protein; Region: NifT; cl02351 717785008182 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785008183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785008184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785008185 catalytic residue [active] 717785008186 NifU-like domain; Region: NifU; cl00484 717785008187 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 717785008188 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 717785008189 iron-sulfur cluster [ion binding]; other site 717785008190 [2Fe-2S] cluster binding site [ion binding]; other site 717785008191 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 717785008192 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 717785008193 active site residue [active] 717785008194 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 717785008195 active site residue [active] 717785008196 NifQ; Region: NifQ; pfam04891 717785008197 Protein of unknown function (DUF683); Region: DUF683; cl02247 717785008198 Protein of unknown function, DUF269; Region: DUF269; cl03973 717785008199 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 717785008200 nitrogenase molybdenum-iron cofactor biosynthesis protein NifN; Region: nifN; TIGR01285 717785008201 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in...; Region: Nitrogenase_NifN_1; cd01966 717785008202 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 717785008203 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in...; Region: Nitrogenase_NifE_I; cd01968 717785008204 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 717785008205 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 717785008206 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 717785008207 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems. Mo-...; Region: Nitrogenase_MoFe_beta; cd01974 717785008208 MoFe protein beta/alpha subunit interactions; other site 717785008209 Beta subunit P cluster binding residues; other site 717785008210 MoFe protein beta subunit/Fe protein contacts; other site 717785008211 MoFe protein dimer/ dimer interactions; other site 717785008212 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 717785008213 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 717785008214 MoFe protein alpha/beta subunit interactions; other site 717785008215 Alpha subunit P cluster binding residues; other site 717785008216 FeMoco binding residues [chemical binding]; other site 717785008217 MoFe protein alpha subunit/Fe protein contacts; other site 717785008218 MoFe protein dimer/ dimer interactions; other site 717785008219 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 717785008220 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 717785008221 Nucleotide-binding sites [chemical binding]; other site 717785008222 Walker A motif; other site 717785008223 Switch I region of nucleotide binding site; other site 717785008224 Fe4S4 binding sites [ion binding]; other site 717785008225 Switch II region of nucleotide binding site; other site 717785008226 Fe-S metabolism associated domain; Region: SufE; cl00951 717785008227 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 717785008228 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 717785008229 dimer interface [polypeptide binding]; other site 717785008230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008231 catalytic residue [active] 717785008232 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 717785008233 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 717785008234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785008235 catalytic residue [active] 717785008236 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 717785008237 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 717785008238 FeS assembly ATPase SufC; Region: sufC; TIGR01978 717785008239 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 717785008240 Walker A/P-loop; other site 717785008241 ATP binding site [chemical binding]; other site 717785008242 Q-loop/lid; other site 717785008243 ABC transporter signature motif; other site 717785008244 Walker B; other site 717785008245 D-loop; other site 717785008246 H-loop/switch region; other site 717785008247 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 717785008248 putative ABC transporter; Region: ycf24; CHL00085 717785008249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008250 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 717785008251 molybdenum transport protein ModD; Provisional; Region: PRK06096 717785008252 dimerization interface [polypeptide binding]; other site 717785008253 active site 717785008254 Nif-specific regulatory protein; Region: nifA; TIGR01817 717785008255 GAF domain; Region: GAF; cl00853 717785008256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785008257 Walker A motif; other site 717785008258 ATP binding site [chemical binding]; other site 717785008259 Walker B motif; other site 717785008260 arginine finger; other site 717785008261 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785008262 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 717785008263 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 717785008264 iron-sulfur cluster [ion binding]; other site 717785008265 [2Fe-2S] cluster binding site [ion binding]; other site 717785008266 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 717785008267 C-terminal domain interface [polypeptide binding]; other site 717785008268 GSH binding site (G-site) [chemical binding]; other site 717785008269 dimer interface [polypeptide binding]; other site 717785008270 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 717785008271 N-terminal domain interface [polypeptide binding]; other site 717785008272 dimer interface [polypeptide binding]; other site 717785008273 substrate binding pocket (H-site) [chemical binding]; other site 717785008274 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 717785008275 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 717785008276 multicopper oxidase; Provisional; Region: PRK10965 717785008277 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785008278 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785008279 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 717785008280 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 717785008281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 717785008282 catalytic Zn binding site [ion binding]; other site 717785008283 structural Zn binding site [ion binding]; other site 717785008284 NAD(P) binding site [chemical binding]; other site 717785008285 Cytochrome c; Region: Cytochrom_C; cl11414 717785008286 Cytochrome c; Region: Cytochrom_C; cl11414 717785008287 Cupin domain; Region: Cupin_2; cl09118 717785008288 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 717785008289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785008290 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 717785008291 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 717785008292 Walker A/P-loop; other site 717785008293 ATP binding site [chemical binding]; other site 717785008294 Q-loop/lid; other site 717785008295 ABC transporter signature motif; other site 717785008296 Walker B; other site 717785008297 D-loop; other site 717785008298 H-loop/switch region; other site 717785008299 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785008300 EthD protein; Region: EthD; cl06234 717785008301 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 717785008302 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785008303 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 717785008304 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 717785008305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785008306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008307 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 717785008308 Fusaric acid resistance protein family; Region: FUSC; pfam04632 717785008309 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 717785008310 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 717785008311 Dienelactone hydrolase family; Region: DLH; pfam01738 717785008312 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 717785008313 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785008314 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 717785008315 Walker A/P-loop; other site 717785008316 ATP binding site [chemical binding]; other site 717785008317 Q-loop/lid; other site 717785008318 ABC transporter signature motif; other site 717785008319 Walker B; other site 717785008320 D-loop; other site 717785008321 H-loop/switch region; other site 717785008322 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 717785008323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008324 Walker A/P-loop; other site 717785008325 ATP binding site [chemical binding]; other site 717785008326 Q-loop/lid; other site 717785008327 ABC transporter signature motif; other site 717785008328 Walker B; other site 717785008329 D-loop; other site 717785008330 H-loop/switch region; other site 717785008331 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 717785008332 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 717785008333 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 717785008334 Gram-negative bacterial tonB protein; Region: TonB; cl10048 717785008335 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 717785008336 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785008337 N-terminal plug; other site 717785008338 ligand-binding site [chemical binding]; other site 717785008339 Imelysin; Region: Peptidase_M75; cl09159 717785008340 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 717785008341 Imelysin; Region: Peptidase_M75; cl09159 717785008342 Iron permease FTR1 family; Region: FTR1; cl00475 717785008343 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 717785008344 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 717785008345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 717785008346 ABC-ATPase subunit interface; other site 717785008347 dimer interface [polypeptide binding]; other site 717785008348 putative PBP binding regions; other site 717785008349 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 717785008350 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 717785008351 metal binding site [ion binding]; metal-binding site 717785008352 High-affinity nickel-transport protein; Region: NicO; cl00964 717785008353 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785008354 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785008355 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 717785008356 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 717785008357 Cytochrome c; Region: Cytochrom_C; cl11414 717785008358 Cytochrome c; Region: Cytochrom_C; cl11414 717785008359 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785008360 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785008361 Trp docking motif; other site 717785008362 'Velcro' closure; other site 717785008363 active site 717785008364 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 717785008365 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 717785008366 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 717785008367 transcriptional regulator; Provisional; Region: PRK10632 717785008368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 717785008370 putative effector binding pocket; other site 717785008371 putative dimerization interface [polypeptide binding]; other site 717785008372 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 717785008373 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 717785008374 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 717785008375 TPP-binding site; other site 717785008376 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 717785008377 PYR/PP interface [polypeptide binding]; other site 717785008378 dimer interface [polypeptide binding]; other site 717785008379 TPP binding site [chemical binding]; other site 717785008380 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 717785008381 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 717785008382 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 717785008383 VacJ like lipoprotein; Region: VacJ; cl01073 717785008384 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 717785008385 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785008386 ligand binding site [chemical binding]; other site 717785008387 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 717785008388 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 717785008389 B12 binding site [chemical binding]; other site 717785008390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785008391 FeS/SAM binding site; other site 717785008392 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 717785008393 LytB protein; Region: LYTB; cl00507 717785008394 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 717785008395 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 717785008396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785008397 FeS/SAM binding site; other site 717785008398 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 717785008399 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 717785008400 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 717785008401 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 717785008402 Active site cavity [active] 717785008403 catalytic acid [active] 717785008404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785008405 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 717785008406 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 717785008407 active site lid residues [active] 717785008408 substrate binding pocket [chemical binding]; other site 717785008409 catalytic residues [active] 717785008410 substrate-Mg2+ binding site; other site 717785008411 aspartate-rich region 1; other site 717785008412 aspartate-rich region 2; other site 717785008413 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 717785008414 active site lid residues [active] 717785008415 substrate binding pocket [chemical binding]; other site 717785008416 catalytic residues [active] 717785008417 substrate-Mg2+ binding site; other site 717785008418 aspartate-rich region 1; other site 717785008419 aspartate-rich region 2; other site 717785008420 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 717785008421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 717785008422 active site 717785008423 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 717785008424 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 717785008425 putative NADP binding site [chemical binding]; other site 717785008426 putative substrate binding site [chemical binding]; other site 717785008427 active site 717785008428 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 717785008429 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 717785008430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785008431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785008432 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785008433 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 717785008434 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 717785008435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785008436 NAD(P) binding site [chemical binding]; other site 717785008437 active site 717785008438 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 717785008439 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 717785008440 Walker A/P-loop; other site 717785008441 ATP binding site [chemical binding]; other site 717785008442 Q-loop/lid; other site 717785008443 ABC transporter signature motif; other site 717785008444 Walker B; other site 717785008445 D-loop; other site 717785008446 H-loop/switch region; other site 717785008447 ABC-2 type transporter; Region: ABC2_membrane; cl11417 717785008448 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008449 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 717785008450 NAD(P) binding site [chemical binding]; other site 717785008451 catalytic residues [active] 717785008452 catalytic residues [active] 717785008453 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 717785008454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785008455 inhibitor-cofactor binding pocket; inhibition site 717785008456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008457 catalytic residue [active] 717785008458 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 717785008459 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1,2-...; Region: Dehydratase_LU; cl12104 717785008460 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 717785008461 alpha-beta subunit interface [polypeptide binding]; other site 717785008462 alpha-gamma subunit interface [polypeptide binding]; other site 717785008463 active site 717785008464 substrate and K+ binding site; other site 717785008465 K+ binding site [ion binding]; other site 717785008466 cobalamin binding site [chemical binding]; other site 717785008467 Dehydratase medium subunit; Region: Dehydratase_MU; cl03516 717785008468 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 717785008469 Isochorismatase family; Region: Isochorismatase; pfam00857 717785008470 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 717785008471 catalytic triad [active] 717785008472 conserved cis-peptide bond; other site 717785008473 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785008474 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 717785008475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785008476 NAD(P) binding site [chemical binding]; other site 717785008477 active site 717785008478 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 717785008479 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785008480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785008481 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785008482 active site 717785008483 substrate binding site [chemical binding]; other site 717785008484 Phosphotransferase enzyme family; Region: APH; pfam01636 717785008485 ATP binding site [chemical binding]; other site 717785008486 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 717785008487 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 717785008488 tetrameric interface [polypeptide binding]; other site 717785008489 NAD binding site [chemical binding]; other site 717785008490 catalytic residues [active] 717785008491 substrate binding site [chemical binding]; other site 717785008492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008493 dimer interface [polypeptide binding]; other site 717785008494 conserved gate region; other site 717785008495 putative PBP binding loops; other site 717785008496 ABC-ATPase subunit interface; other site 717785008497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008498 dimer interface [polypeptide binding]; other site 717785008499 putative PBP binding loops; other site 717785008500 ABC-ATPase subunit interface; other site 717785008501 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785008502 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008503 Walker A/P-loop; other site 717785008504 ATP binding site [chemical binding]; other site 717785008505 Q-loop/lid; other site 717785008506 ABC transporter signature motif; other site 717785008507 Walker B; other site 717785008508 D-loop; other site 717785008509 H-loop/switch region; other site 717785008510 TOBE domain; Region: TOBE_2; cl01440 717785008511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008514 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 717785008515 Walker A/P-loop; other site 717785008516 ATP binding site [chemical binding]; other site 717785008517 Q-loop/lid; other site 717785008518 ABC transporter signature motif; other site 717785008519 Walker B; other site 717785008520 D-loop; other site 717785008521 H-loop/switch region; other site 717785008522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008523 dimer interface [polypeptide binding]; other site 717785008524 conserved gate region; other site 717785008525 putative PBP binding loops; other site 717785008526 ABC-ATPase subunit interface; other site 717785008527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008528 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 717785008529 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 717785008530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785008531 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 717785008532 DNA binding site [nucleotide binding] 717785008533 active site 717785008534 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785008535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785008536 DNA-binding site [nucleotide binding]; DNA binding site 717785008537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785008538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008539 homodimer interface [polypeptide binding]; other site 717785008540 catalytic residue [active] 717785008541 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785008542 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 717785008543 putative substrate binding pocket [chemical binding]; other site 717785008544 AC domain interface; other site 717785008545 catalytic triad [active] 717785008546 AB domain interface; other site 717785008547 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 717785008548 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785008549 ATP binding site [chemical binding]; other site 717785008550 putative Mg++ binding site [ion binding]; other site 717785008551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785008552 nucleotide binding region [chemical binding]; other site 717785008553 ATP-binding site [chemical binding]; other site 717785008554 RQC domain; Region: RQC; pfam09382 717785008555 HRDC domain; Region: HRDC; cl02578 717785008556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008557 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 717785008558 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 717785008559 dimer interface [polypeptide binding]; other site 717785008560 motif 1; other site 717785008561 motif 2; other site 717785008562 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785008563 active site 717785008564 motif 3; other site 717785008565 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 717785008566 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 717785008567 dimer interface [polypeptide binding]; other site 717785008568 motif 1; other site 717785008569 motif 2; other site 717785008570 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785008571 active site 717785008572 motif 3; other site 717785008573 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 717785008574 anticodon binding site; other site 717785008575 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 717785008576 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 717785008577 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 717785008578 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 717785008579 putative dimer interface [polypeptide binding]; other site 717785008580 active site pocket [active] 717785008581 putative cataytic base [active] 717785008582 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 717785008583 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 717785008584 Cysteine-rich domain; Region: CCG; pfam02754 717785008585 FAD binding domain; Region: FAD_binding_4; pfam01565 717785008586 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 717785008587 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 717785008588 FAD binding domain; Region: FAD_binding_4; pfam01565 717785008589 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 717785008590 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 717785008591 UbiA prenyltransferase family; Region: UbiA; cl00337 717785008592 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 717785008593 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785008594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785008595 Walker A/P-loop; other site 717785008596 ATP binding site [chemical binding]; other site 717785008597 Q-loop/lid; other site 717785008598 ABC transporter signature motif; other site 717785008599 Walker B; other site 717785008600 D-loop; other site 717785008601 H-loop/switch region; other site 717785008602 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 717785008603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785008604 putative acyl-acceptor binding pocket; other site 717785008605 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 717785008606 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 717785008607 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 717785008608 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 717785008609 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 717785008610 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 717785008611 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 717785008612 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 717785008613 generic binding surface II; other site 717785008614 generic binding surface I; other site 717785008615 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 717785008616 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 717785008617 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785008618 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 717785008619 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 717785008620 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 717785008621 nucleophile elbow; other site 717785008622 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 717785008623 nucleoside/Zn binding site; other site 717785008624 dimer interface [polypeptide binding]; other site 717785008625 catalytic motif [active] 717785008626 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 717785008627 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785008628 RNA binding surface [nucleotide binding]; other site 717785008629 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 717785008630 probable active site [active] 717785008631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785008632 S-adenosylmethionine binding site [chemical binding]; other site 717785008633 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 717785008634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 717785008635 glucose/galactose transporter; Region: gluP; TIGR01272 717785008636 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 717785008637 Ferritin-like domain; Region: Ferritin; pfam00210 717785008638 heme binding site [chemical binding]; other site 717785008639 ferroxidase pore; other site 717785008640 ferroxidase diiron center [ion binding]; other site 717785008641 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 717785008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008643 ATP binding site [chemical binding]; other site 717785008644 Mg2+ binding site [ion binding]; other site 717785008645 G-X-G motif; other site 717785008646 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 717785008647 ATP binding site [chemical binding]; other site 717785008648 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 717785008649 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 717785008650 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 717785008651 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 717785008652 dimer interface [polypeptide binding]; other site 717785008653 active site 717785008654 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785008655 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785008656 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785008657 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785008658 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785008659 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785008660 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 717785008661 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 717785008662 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785008663 active site 717785008664 HIGH motif; other site 717785008665 nucleotide binding site [chemical binding]; other site 717785008666 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 717785008667 active site 717785008668 KMSKS motif; other site 717785008669 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 717785008670 tRNA binding surface [nucleotide binding]; other site 717785008671 anticodon binding site; other site 717785008672 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 717785008673 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 717785008674 active site 717785008675 Riboflavin kinase; Region: Flavokinase; pfam01687 717785008676 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 717785008677 dimer interaction site [polypeptide binding]; other site 717785008678 substrate-binding tunnel; other site 717785008679 active site 717785008680 catalytic site [active] 717785008681 substrate binding site [chemical binding]; other site 717785008682 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 717785008683 putative transporter; Provisional; Region: PRK11660 717785008684 Sulfate transporter family; Region: Sulfate_transp; cl00967 717785008685 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 717785008686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 717785008687 acyl-CoA synthetase; Validated; Region: PRK08162 717785008688 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785008689 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785008690 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 717785008691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 717785008692 putative C-terminal domain interface [polypeptide binding]; other site 717785008693 putative GSH binding site (G-site) [chemical binding]; other site 717785008694 putative dimer interface [polypeptide binding]; other site 717785008695 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 717785008696 putative N-terminal domain interface [polypeptide binding]; other site 717785008697 putative dimer interface [polypeptide binding]; other site 717785008698 putative substrate binding pocket (H-site) [chemical binding]; other site 717785008699 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 717785008700 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 717785008701 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 717785008702 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 717785008703 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785008704 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 717785008705 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 717785008706 putative heme binding pocket [chemical binding]; other site 717785008707 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 717785008708 putative hydrophobic ligand binding site [chemical binding]; other site 717785008709 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 717785008710 putative hydrophobic ligand binding site [chemical binding]; other site 717785008711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785008712 dimerization interface [polypeptide binding]; other site 717785008713 putative DNA binding site [nucleotide binding]; other site 717785008714 putative Zn2+ binding site [ion binding]; other site 717785008715 Protein of unknown function (DUF465); Region: DUF465; cl01070 717785008716 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 717785008717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785008718 ATP-dependent DNA ligase; Validated; Region: PRK09247 717785008719 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 717785008720 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 717785008721 active site 717785008722 DNA binding site [nucleotide binding] 717785008723 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 717785008724 DNA binding site [nucleotide binding] 717785008725 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 717785008726 homodimer interface [polypeptide binding]; other site 717785008727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785008728 catalytic residue [active] 717785008729 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 717785008730 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 717785008731 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 717785008732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785008733 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 717785008734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 717785008735 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785008736 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 717785008737 Gram-negative bacterial tonB protein; Region: TonB; cl10048 717785008738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 717785008739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785008740 dimer interface [polypeptide binding]; other site 717785008741 phosphorylation site [posttranslational modification] 717785008742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008743 ATP binding site [chemical binding]; other site 717785008744 Mg2+ binding site [ion binding]; other site 717785008745 G-X-G motif; other site 717785008746 Domain of unknown function DUF87; Region: DUF87; pfam01935 717785008747 AAA-like domain; Region: AAA_10; pfam12846 717785008748 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 717785008749 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 717785008750 Substrate binding site [chemical binding]; other site 717785008751 Cupin domain; Region: Cupin_2; cl09118 717785008752 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 717785008753 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 717785008754 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 717785008755 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 717785008756 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 717785008757 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785008758 protein binding site [polypeptide binding]; other site 717785008759 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785008760 protein binding site [polypeptide binding]; other site 717785008761 FtsH protease regulator HflC; Provisional; Region: PRK11029 717785008762 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 717785008763 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 717785008764 HflK protein; Region: hflK; TIGR01933 717785008765 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 717785008766 folate binding site [chemical binding]; other site 717785008767 NADP+ binding site [chemical binding]; other site 717785008768 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 717785008769 dimerization interface [polypeptide binding]; other site 717785008770 active site 717785008771 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 717785008772 Stringent starvation protein B; Region: SspB; cl01120 717785008773 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 717785008774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 717785008775 dimerization interface [polypeptide binding]; other site 717785008776 putative DNA binding site [nucleotide binding]; other site 717785008777 putative Zn2+ binding site [ion binding]; other site 717785008778 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 717785008779 putative hydrophobic ligand binding site [chemical binding]; other site 717785008780 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 717785008781 fumarate hydratase; Reviewed; Region: fumC; PRK00485 717785008782 Class II fumarases; Region: Fumarase_classII; cd01362 717785008783 active site 717785008784 tetramer interface [polypeptide binding]; other site 717785008785 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 717785008786 Peptidase M15; Region: Peptidase_M15_3; cl01194 717785008787 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 717785008788 DNA-binding site [nucleotide binding]; DNA binding site 717785008789 RNA-binding motif; other site 717785008790 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 717785008791 rRNA binding site [nucleotide binding]; other site 717785008792 predicted 30S ribosome binding site; other site 717785008793 TLC ATP/ADP transporter; Region: TLC; cl03940 717785008794 TLC ATP/ADP transporter; Region: TLC; cl03940 717785008795 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 717785008796 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 717785008797 MgtC family; Region: MgtC; cl12207 717785008798 DNA polymerase I; Provisional; Region: PRK05755 717785008799 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 717785008800 active site 717785008801 metal binding site 1 [ion binding]; metal-binding site 717785008802 putative 5' ssDNA interaction site; other site 717785008803 metal binding site 3; metal-binding site 717785008804 metal binding site 2 [ion binding]; metal-binding site 717785008805 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 717785008806 putative DNA binding site [nucleotide binding]; other site 717785008807 putative metal binding site [ion binding]; other site 717785008808 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 717785008809 active site 717785008810 catalytic site [active] 717785008811 substrate binding site [chemical binding]; other site 717785008812 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 717785008813 active site 717785008814 DNA binding site [nucleotide binding] 717785008815 catalytic site [active] 717785008816 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 717785008817 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 717785008818 catalytic triad [active] 717785008819 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785008820 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 717785008821 putative active site [active] 717785008822 catalytic triad [active] 717785008823 putative dimer interface [polypeptide binding]; other site 717785008824 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 717785008825 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785008826 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785008827 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 717785008828 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 717785008829 putative active site [active] 717785008830 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 717785008831 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 717785008832 classical (c) SDRs; Region: SDR_c; cd05233 717785008833 NAD(P) binding site [chemical binding]; other site 717785008834 active site 717785008835 Cupin domain; Region: Cupin_2; cl09118 717785008836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785008837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008838 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785008839 putative effector binding pocket; other site 717785008840 putative dimerization interface [polypeptide binding]; other site 717785008841 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 717785008842 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 717785008843 Walker A/P-loop; other site 717785008844 ATP binding site [chemical binding]; other site 717785008845 Q-loop/lid; other site 717785008846 ABC transporter signature motif; other site 717785008847 Walker B; other site 717785008848 D-loop; other site 717785008849 H-loop/switch region; other site 717785008850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785008852 Phosphotransferase enzyme family; Region: APH; pfam01636 717785008853 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 717785008854 active site 717785008855 ATP binding site [chemical binding]; other site 717785008856 substrate binding site [chemical binding]; other site 717785008857 dimer interface [polypeptide binding]; other site 717785008858 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 717785008859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785008860 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 717785008861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 717785008862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008863 dimer interface [polypeptide binding]; other site 717785008864 conserved gate region; other site 717785008865 putative PBP binding loops; other site 717785008866 ABC-ATPase subunit interface; other site 717785008867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 717785008868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008869 dimer interface [polypeptide binding]; other site 717785008870 conserved gate region; other site 717785008871 putative PBP binding loops; other site 717785008872 ABC-ATPase subunit interface; other site 717785008873 FAD dependent oxidoreductase; Region: DAO; pfam01266 717785008874 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785008875 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 717785008876 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785008877 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785008878 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785008879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785008880 motif II; other site 717785008881 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 717785008882 UreD urease accessory protein; Region: UreD; cl00530 717785008883 LAO/AO transport system ATPase; Region: lao; TIGR00750 717785008884 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785008885 urease subunit alpha; Reviewed; Region: ureC; PRK13308 717785008886 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 717785008887 subunit interactions [polypeptide binding]; other site 717785008888 active site 717785008889 flap region; other site 717785008890 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 717785008891 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 717785008892 alpha-gamma subunit interface [polypeptide binding]; other site 717785008893 beta-gamma subunit interface [polypeptide binding]; other site 717785008894 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 717785008895 alpha-beta subunit interface [polypeptide binding]; other site 717785008896 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 717785008897 UreF; Region: UreF; pfam01730 717785008898 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 717785008899 dimer interface [polypeptide binding]; other site 717785008900 catalytic residues [active] 717785008901 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 717785008902 Sel1 repeat; Region: Sel1; cl02723 717785008903 Sel1 repeat; Region: Sel1; cl02723 717785008904 Sel1 repeat; Region: Sel1; cl02723 717785008905 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 717785008906 iron-sulfur cluster [ion binding]; other site 717785008907 [2Fe-2S] cluster binding site [ion binding]; other site 717785008908 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 717785008909 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 717785008910 Walker A/P-loop; other site 717785008911 ATP binding site [chemical binding]; other site 717785008912 Q-loop/lid; other site 717785008913 ABC transporter signature motif; other site 717785008914 Walker B; other site 717785008915 D-loop; other site 717785008916 H-loop/switch region; other site 717785008917 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 717785008918 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 717785008919 Walker A/P-loop; other site 717785008920 ATP binding site [chemical binding]; other site 717785008921 Q-loop/lid; other site 717785008922 ABC transporter signature motif; other site 717785008923 Walker B; other site 717785008924 D-loop; other site 717785008925 H-loop/switch region; other site 717785008926 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 717785008927 TM-ABC transporter signature motif; other site 717785008928 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 717785008929 TM-ABC transporter signature motif; other site 717785008930 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 717785008931 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 717785008932 ligand binding site [chemical binding]; other site 717785008933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785008935 active site 717785008936 phosphorylation site [posttranslational modification] 717785008937 intermolecular recognition site; other site 717785008938 dimerization interface [polypeptide binding]; other site 717785008939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785008940 DNA binding residues [nucleotide binding] 717785008941 dimerization interface [polypeptide binding]; other site 717785008942 sensory histidine kinase AtoS; Provisional; Region: PRK11360 717785008943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785008944 dimer interface [polypeptide binding]; other site 717785008945 phosphorylation site [posttranslational modification] 717785008946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785008947 ATP binding site [chemical binding]; other site 717785008948 Mg2+ binding site [ion binding]; other site 717785008949 G-X-G motif; other site 717785008950 Response regulator receiver domain; Region: Response_reg; pfam00072 717785008951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785008952 active site 717785008953 phosphorylation site [posttranslational modification] 717785008954 intermolecular recognition site; other site 717785008955 dimerization interface [polypeptide binding]; other site 717785008956 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785008957 ligand binding site [chemical binding]; other site 717785008958 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 717785008959 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785008960 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 717785008961 homotrimer interaction site [polypeptide binding]; other site 717785008962 putative active site [active] 717785008963 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 717785008964 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 717785008965 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 717785008966 NAD(P) binding site [chemical binding]; other site 717785008967 catalytic residues [active] 717785008968 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 717785008969 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 717785008970 metal binding site [ion binding]; metal-binding site 717785008971 putative dimer interface [polypeptide binding]; other site 717785008972 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 717785008973 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785008974 FMN binding site [chemical binding]; other site 717785008975 active site 717785008976 homodimer interface [polypeptide binding]; other site 717785008977 putative catalytic residue [active] 717785008978 4Fe-4S cluster binding site [ion binding]; other site 717785008979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785008980 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 717785008981 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 717785008982 FMN binding site [chemical binding]; other site 717785008983 active site 717785008984 homodimer interface [polypeptide binding]; other site 717785008985 putative catalytic residue [active] 717785008986 4Fe-4S cluster binding site [ion binding]; other site 717785008987 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 717785008988 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785008989 Walker A/P-loop; other site 717785008990 ATP binding site [chemical binding]; other site 717785008991 Q-loop/lid; other site 717785008992 ABC transporter signature motif; other site 717785008993 Walker B; other site 717785008994 D-loop; other site 717785008995 H-loop/switch region; other site 717785008996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785008997 dimer interface [polypeptide binding]; other site 717785008998 conserved gate region; other site 717785008999 putative PBP binding loops; other site 717785009000 ABC-ATPase subunit interface; other site 717785009001 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009003 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 717785009004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785009005 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 717785009006 putative substrate binding pocket [chemical binding]; other site 717785009007 dimerization interface [polypeptide binding]; other site 717785009008 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785009009 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785009010 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 717785009011 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 717785009012 [4Fe-4S] binding site [ion binding]; other site 717785009013 molybdopterin cofactor binding site; other site 717785009014 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 717785009015 molybdopterin cofactor binding site; other site 717785009016 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 717785009017 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 717785009018 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 717785009019 [2Fe-2S] cluster binding site [ion binding]; other site 717785009020 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 717785009021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009022 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 717785009023 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 717785009024 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 717785009025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009026 putative substrate translocation pore; other site 717785009027 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009029 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 717785009030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009031 active site 717785009032 phosphorylation site [posttranslational modification] 717785009033 intermolecular recognition site; other site 717785009034 dimerization interface [polypeptide binding]; other site 717785009035 ANTAR domain; Region: ANTAR; pfam03861 717785009036 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785009037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 717785009038 Uncharacterized conserved protein [Function unknown]; Region: COG5361 717785009039 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 717785009040 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 717785009041 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 717785009042 Nif-specific regulatory protein; Region: nifA; TIGR01817 717785009043 GAF domain; Region: GAF; cl00853 717785009044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785009045 Walker A motif; other site 717785009046 ATP binding site [chemical binding]; other site 717785009047 Walker B motif; other site 717785009048 arginine finger; other site 717785009049 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785009050 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 717785009051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009052 OsmC-like protein; Region: OsmC; cl00767 717785009053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 717785009054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785009055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 717785009056 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 717785009057 Rubredoxin; Region: Rubredoxin; pfam00301 717785009058 iron binding site [ion binding]; other site 717785009059 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 717785009060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785009062 dimer interface [polypeptide binding]; other site 717785009063 conserved gate region; other site 717785009064 putative PBP binding loops; other site 717785009065 ABC-ATPase subunit interface; other site 717785009066 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 717785009067 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 717785009068 Walker A/P-loop; other site 717785009069 ATP binding site [chemical binding]; other site 717785009070 Q-loop/lid; other site 717785009071 ABC transporter signature motif; other site 717785009072 Walker B; other site 717785009073 D-loop; other site 717785009074 H-loop/switch region; other site 717785009075 cyanate hydratase; Validated; Region: PRK02866 717785009076 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 717785009077 oligomer interface [polypeptide binding]; other site 717785009078 active site 717785009079 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 717785009080 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 717785009081 N-terminal plug; other site 717785009082 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 717785009083 ligand-binding site [chemical binding]; other site 717785009084 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 717785009085 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 717785009086 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 717785009087 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 717785009088 generic binding surface II; other site 717785009089 generic binding surface I; other site 717785009090 DNA Polymerase Y-family; Region: PolY_like; cd03468 717785009091 active site 717785009092 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 717785009093 DNA binding site [nucleotide binding] 717785009094 Cell division inhibitor SulA; Region: SulA; cl01880 717785009095 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 717785009096 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 717785009097 dimerization interface [polypeptide binding]; other site 717785009098 PAS fold; Region: PAS_7; pfam12860 717785009099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009100 metal binding site [ion binding]; metal-binding site 717785009101 active site 717785009102 I-site; other site 717785009103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009104 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785009105 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785009106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785009107 dimer interface [polypeptide binding]; other site 717785009108 conserved gate region; other site 717785009109 putative PBP binding loops; other site 717785009110 ABC-ATPase subunit interface; other site 717785009111 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 717785009112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785009113 dimer interface [polypeptide binding]; other site 717785009114 conserved gate region; other site 717785009115 putative PBP binding loops; other site 717785009116 ABC-ATPase subunit interface; other site 717785009117 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 717785009118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009119 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 717785009120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785009121 sequence-specific DNA binding site [nucleotide binding]; other site 717785009122 salt bridge; other site 717785009123 Cupin domain; Region: Cupin_2; cl09118 717785009124 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 717785009125 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 717785009126 Walker A/P-loop; other site 717785009127 ATP binding site [chemical binding]; other site 717785009128 Q-loop/lid; other site 717785009129 ABC transporter signature motif; other site 717785009130 Walker B; other site 717785009131 D-loop; other site 717785009132 H-loop/switch region; other site 717785009133 TOBE domain; Region: TOBE_2; cl01440 717785009134 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 717785009135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785009136 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 717785009137 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785009138 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 717785009139 Predicted dehydrogenase [General function prediction only]; Region: COG0579 717785009140 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785009141 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 717785009142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 717785009143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009144 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 717785009145 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 717785009146 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 717785009147 ethanolamine permease; Region: 2A0305; TIGR00908 717785009148 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 717785009149 response regulator FixJ; Provisional; Region: fixJ; PRK09390 717785009150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009151 active site 717785009152 phosphorylation site [posttranslational modification] 717785009153 intermolecular recognition site; other site 717785009154 dimerization interface [polypeptide binding]; other site 717785009155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785009156 DNA binding residues [nucleotide binding] 717785009157 dimerization interface [polypeptide binding]; other site 717785009158 MASE1; Region: MASE1; pfam05231 717785009159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785009160 phosphorylation site [posttranslational modification] 717785009161 dimer interface [polypeptide binding]; other site 717785009162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009163 ATP binding site [chemical binding]; other site 717785009164 Mg2+ binding site [ion binding]; other site 717785009165 G-X-G motif; other site 717785009166 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785009167 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 717785009168 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 717785009169 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 717785009170 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 717785009171 Moco binding site; other site 717785009172 metal coordination site [ion binding]; other site 717785009173 mercuric reductase; Validated; Region: PRK06370 717785009174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785009177 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 717785009178 substrate binding site [chemical binding]; other site 717785009179 ATP binding site [chemical binding]; other site 717785009180 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 717785009181 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 717785009182 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785009183 HSP70 interaction site [polypeptide binding]; other site 717785009184 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 717785009185 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 717785009186 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 717785009187 nudix motif; other site 717785009188 Surface antigen; Region: Surface_Ag_2; cl01155 717785009189 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 717785009190 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 717785009191 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 717785009192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785009193 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 717785009194 osmolarity response regulator; Provisional; Region: ompR; PRK09468 717785009195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009196 active site 717785009197 phosphorylation site [posttranslational modification] 717785009198 intermolecular recognition site; other site 717785009199 dimerization interface [polypeptide binding]; other site 717785009200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785009201 DNA binding site [nucleotide binding] 717785009202 PAS domain S-box; Region: sensory_box; TIGR00229 717785009203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785009204 putative active site [active] 717785009205 heme pocket [chemical binding]; other site 717785009206 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 717785009207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785009208 putative active site [active] 717785009209 heme pocket [chemical binding]; other site 717785009210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785009211 dimer interface [polypeptide binding]; other site 717785009212 phosphorylation site [posttranslational modification] 717785009213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009214 ATP binding site [chemical binding]; other site 717785009215 Mg2+ binding site [ion binding]; other site 717785009216 G-X-G motif; other site 717785009217 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009219 active site 717785009220 phosphorylation site [posttranslational modification] 717785009221 intermolecular recognition site; other site 717785009222 dimerization interface [polypeptide binding]; other site 717785009223 Protein required for attachment to host cells; Region: Host_attach; cl02398 717785009224 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 717785009225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785009226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785009227 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 717785009228 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 717785009229 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 717785009230 FOG: CBS domain [General function prediction only]; Region: COG0517 717785009231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 717785009232 BON domain; Region: BON; cl02771 717785009233 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 717785009234 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 717785009235 putative NAD(P) binding site [chemical binding]; other site 717785009236 putative substrate binding site [chemical binding]; other site 717785009237 catalytic Zn binding site [ion binding]; other site 717785009238 structural Zn binding site [ion binding]; other site 717785009239 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 717785009240 dimer interaction site [polypeptide binding]; other site 717785009241 substrate-binding tunnel; other site 717785009242 active site 717785009243 catalytic site [active] 717785009244 substrate binding site [chemical binding]; other site 717785009245 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 717785009246 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785009247 NAD binding site [chemical binding]; other site 717785009248 homotetramer interface [polypeptide binding]; other site 717785009249 homodimer interface [polypeptide binding]; other site 717785009250 substrate binding site [chemical binding]; other site 717785009251 active site 717785009252 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785009253 E3 interaction surface; other site 717785009254 lipoyl attachment site [posttranslational modification]; other site 717785009255 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 717785009256 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785009257 ligand binding site [chemical binding]; other site 717785009258 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785009259 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 717785009260 Catalytic site; other site 717785009261 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 717785009262 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 717785009263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009265 putative transporter; Provisional; Region: PRK10504 717785009266 putative substrate translocation pore; other site 717785009267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009268 Coenzyme A transferase; Region: CoA_trans; cl00773 717785009269 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 717785009270 Coenzyme A transferase; Region: CoA_trans; cl00773 717785009271 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 717785009272 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 717785009273 Domain of unknown function DUF59; Region: DUF59; cl00941 717785009274 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 717785009275 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 717785009276 Walker A motif; other site 717785009277 Protein of unknown function (DUF971); Region: DUF971; cl01414 717785009278 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 717785009279 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 717785009280 GTP binding site [chemical binding]; other site 717785009281 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 717785009282 Walker A motif; other site 717785009283 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 717785009284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785009285 FeS/SAM binding site; other site 717785009286 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 717785009287 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 717785009288 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 717785009289 Walker A/P-loop; other site 717785009290 ATP binding site [chemical binding]; other site 717785009291 Q-loop/lid; other site 717785009292 ABC transporter signature motif; other site 717785009293 Walker B; other site 717785009294 D-loop; other site 717785009295 H-loop/switch region; other site 717785009296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009297 active site 717785009298 phosphorylation site [posttranslational modification] 717785009299 intermolecular recognition site; other site 717785009300 dimerization interface [polypeptide binding]; other site 717785009301 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785009302 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 717785009303 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785009304 Walker A/P-loop; other site 717785009305 ATP binding site [chemical binding]; other site 717785009306 Q-loop/lid; other site 717785009307 ABC transporter signature motif; other site 717785009308 Walker B; other site 717785009309 D-loop; other site 717785009310 H-loop/switch region; other site 717785009311 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 717785009312 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 717785009313 putative active site [active] 717785009314 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785009315 putative acyl-acceptor binding pocket; other site 717785009316 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 717785009317 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 717785009318 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 717785009319 active site 717785009320 dimer interface [polypeptide binding]; other site 717785009321 effector binding site; other site 717785009322 TSCPD domain; Region: TSCPD; cl14834 717785009323 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 717785009324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785009325 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 717785009326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785009327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009328 homodimer interface [polypeptide binding]; other site 717785009329 catalytic residue [active] 717785009330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785009331 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 717785009332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785009333 S-adenosylmethionine binding site [chemical binding]; other site 717785009334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785009336 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 717785009337 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 717785009338 putative metal binding site [ion binding]; other site 717785009339 cell division protein ZipA; Provisional; Region: PRK03427 717785009340 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 717785009341 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 717785009342 NAD(P) binding site [chemical binding]; other site 717785009343 homotetramer interface [polypeptide binding]; other site 717785009344 homodimer interface [polypeptide binding]; other site 717785009345 active site 717785009346 putative acyltransferase; Provisional; Region: PRK05790 717785009347 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785009348 dimer interface [polypeptide binding]; other site 717785009349 active site 717785009350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 717785009351 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 717785009352 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 717785009353 putative diguanylate cyclase; Provisional; Region: PRK09776 717785009354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009355 metal binding site [ion binding]; metal-binding site 717785009356 active site 717785009357 I-site; other site 717785009358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009359 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 717785009360 Transglycosylase; Region: Transgly; cl07896 717785009361 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 717785009362 substrate binding pocket [chemical binding]; other site 717785009363 chain length determination region; other site 717785009364 substrate-Mg2+ binding site; other site 717785009365 catalytic residues [active] 717785009366 aspartate-rich region 1; other site 717785009367 active site lid residues [active] 717785009368 aspartate-rich region 2; other site 717785009369 Surface antigen; Region: Surface_Ag_2; cl01155 717785009370 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 717785009371 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 717785009372 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 717785009373 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 717785009374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 717785009375 putative PBP binding regions; other site 717785009376 ABC-ATPase subunit interface; other site 717785009377 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 717785009378 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 717785009379 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785009380 metal binding site 2 [ion binding]; metal-binding site 717785009381 putative DNA binding helix; other site 717785009382 metal binding site 1 [ion binding]; metal-binding site 717785009383 dimer interface [polypeptide binding]; other site 717785009384 structural Zn2+ binding site [ion binding]; other site 717785009385 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 717785009386 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 717785009387 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 717785009388 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785009389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009390 putative substrate translocation pore; other site 717785009391 MltA-interacting protein MipA; Region: MipA; cl01504 717785009392 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 717785009393 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 717785009394 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785009395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 717785009396 DNA-binding site [nucleotide binding]; DNA binding site 717785009397 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 717785009398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785009399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009400 homodimer interface [polypeptide binding]; other site 717785009401 catalytic residue [active] 717785009402 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 717785009403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785009404 S-adenosylmethionine binding site [chemical binding]; other site 717785009405 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785009406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785009407 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 717785009408 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 717785009409 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 717785009410 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 717785009411 dimer interface [polypeptide binding]; other site 717785009412 anticodon binding site; other site 717785009413 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 717785009414 homodimer interface [polypeptide binding]; other site 717785009415 motif 1; other site 717785009416 active site 717785009417 motif 2; other site 717785009418 GAD domain; Region: GAD; pfam02938 717785009419 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 717785009420 active site 717785009421 motif 3; other site 717785009422 ribonuclease D; Region: rnd; TIGR01388 717785009423 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 717785009424 putative active site [active] 717785009425 catalytic site [active] 717785009426 putative substrate binding site [chemical binding]; other site 717785009427 HRDC domain; Region: HRDC; cl02578 717785009428 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 717785009429 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785009430 HSP70 interaction site [polypeptide binding]; other site 717785009431 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 717785009432 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 717785009433 exopolyphosphatase; Region: exo_poly_only; TIGR03706 717785009434 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 717785009435 polyphosphate kinase; Provisional; Region: PRK05443 717785009436 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 717785009437 putative domain interface [polypeptide binding]; other site 717785009438 putative active site [active] 717785009439 catalytic site [active] 717785009440 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 717785009441 putative active site [active] 717785009442 putative domain interface [polypeptide binding]; other site 717785009443 catalytic site [active] 717785009444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785009445 Domain of unknown function DUF20; Region: UPF0118; cl00465 717785009446 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 717785009447 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 717785009448 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 717785009449 dimerization interface [polypeptide binding]; other site 717785009450 putative ATP binding site [chemical binding]; other site 717785009451 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785009452 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 717785009453 Trp docking motif; other site 717785009454 'Velcro' closure; other site 717785009455 active site 717785009456 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 717785009457 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 717785009458 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 717785009459 active site 717785009460 TDP-binding site; other site 717785009461 acceptor substrate-binding pocket; other site 717785009462 homodimer interface [polypeptide binding]; other site 717785009463 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 717785009464 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 717785009465 active site 717785009466 substrate binding site [chemical binding]; other site 717785009467 cosubstrate binding site; other site 717785009468 catalytic site [active] 717785009469 Cytochrome P450; Region: p450; cl12078 717785009470 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 717785009471 Evidence 4 : Homologs of previously reported genes of unknown function 717785009472 Evidence 4 : Homologs of previously reported genes of unknown function 717785009473 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 717785009474 active site 717785009475 multimer interface [polypeptide binding]; other site 717785009476 hypothetical protein; Provisional; Region: PRK09272 717785009477 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 717785009478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785009479 Walker A/P-loop; other site 717785009480 ATP binding site [chemical binding]; other site 717785009481 Q-loop/lid; other site 717785009482 ABC transporter signature motif; other site 717785009483 Walker B; other site 717785009484 D-loop; other site 717785009485 H-loop/switch region; other site 717785009486 ABC transporter; Region: ABC_tran_2; pfam12848 717785009487 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 717785009488 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 717785009489 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 717785009490 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 717785009491 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 717785009492 dimer interface [polypeptide binding]; other site 717785009493 motif 1; other site 717785009494 active site 717785009495 motif 2; other site 717785009496 motif 3; other site 717785009497 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 717785009498 tandem repeat interface [polypeptide binding]; other site 717785009499 oligomer interface [polypeptide binding]; other site 717785009500 active site residues [active] 717785009501 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 717785009502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009503 Protein of unknown function (DUF2007); Region: DUF2007; pfam09413 717785009504 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 717785009505 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 717785009506 substrate binding pocket [chemical binding]; other site 717785009507 chain length determination region; other site 717785009508 substrate-Mg2+ binding site; other site 717785009509 catalytic residues [active] 717785009510 aspartate-rich region 1; other site 717785009511 active site lid residues [active] 717785009512 aspartate-rich region 2; other site 717785009513 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 717785009514 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 717785009515 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 717785009516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785009517 binding surface 717785009518 TPR motif; other site 717785009519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785009520 TPR motif; other site 717785009521 binding surface 717785009522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785009523 binding surface 717785009524 TPR motif; other site 717785009525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 717785009526 binding surface 717785009527 TPR motif; other site 717785009528 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 717785009529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785009530 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 717785009531 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 717785009532 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 717785009533 MPT binding site; other site 717785009534 trimer interface [polypeptide binding]; other site 717785009535 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 717785009536 Probable Catalytic site [active] 717785009537 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 717785009538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785009539 FeS/SAM binding site; other site 717785009540 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 717785009541 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785009542 active site 717785009543 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 717785009544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009546 PAS fold; Region: PAS_7; pfam12860 717785009547 PAS domain S-box; Region: sensory_box; TIGR00229 717785009548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 717785009549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009550 metal binding site [ion binding]; metal-binding site 717785009551 active site 717785009552 I-site; other site 717785009553 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009554 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 717785009555 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785009556 minor groove reading motif; other site 717785009557 helix-hairpin-helix signature motif; other site 717785009558 substrate binding pocket [chemical binding]; other site 717785009559 active site 717785009560 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 717785009561 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 717785009562 DNA binding and oxoG recognition site [nucleotide binding] 717785009563 Protein of unknown function (DUF721); Region: DUF721; cl02324 717785009564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785009565 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 717785009566 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 717785009567 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 717785009568 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 717785009569 Walker A/P-loop; other site 717785009570 ATP binding site [chemical binding]; other site 717785009571 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 717785009572 Q-loop/lid; other site 717785009573 ABC transporter signature motif; other site 717785009574 Walker B; other site 717785009575 D-loop; other site 717785009576 H-loop/switch region; other site 717785009577 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 717785009578 ATP synthase A chain; Region: ATP-synt_A; cl00413 717785009579 ATP synthase subunit C; Region: ATP-synt_C; cl00466 717785009580 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 717785009581 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 717785009582 LytB protein; Region: LYTB; cl00507 717785009583 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 717785009584 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 717785009585 Phosphotransferase enzyme family; Region: APH; pfam01636 717785009586 putative active site [active] 717785009587 putative substrate binding site [chemical binding]; other site 717785009588 ATP binding site [chemical binding]; other site 717785009589 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 717785009590 RNA/DNA hybrid binding site [nucleotide binding]; other site 717785009591 active site 717785009592 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 717785009593 catalytic triad [active] 717785009594 dimer interface [polypeptide binding]; other site 717785009595 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 717785009596 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 717785009597 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 717785009598 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 717785009599 PAS fold; Region: PAS_3; pfam08447 717785009600 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 717785009601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009602 metal binding site [ion binding]; metal-binding site 717785009603 active site 717785009604 I-site; other site 717785009605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009606 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 717785009607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785009608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 717785009609 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 717785009610 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 717785009611 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 717785009612 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 717785009613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009614 catalytic residue [active] 717785009615 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 717785009616 Protein of unknown function (DUF983); Region: DUF983; cl02211 717785009617 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 717785009618 Subunit III/VIIa interface [polypeptide binding]; other site 717785009619 Phospholipid binding site [chemical binding]; other site 717785009620 Subunit I/III interface [polypeptide binding]; other site 717785009621 Subunit III/VIb interface [polypeptide binding]; other site 717785009622 Subunit III/VIa interface; other site 717785009623 Subunit III/Vb interface [polypeptide binding]; other site 717785009624 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 717785009625 UbiA prenyltransferase family; Region: UbiA; cl00337 717785009626 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785009627 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 717785009628 Subunit I/III interface [polypeptide binding]; other site 717785009629 D-pathway; other site 717785009630 Subunit I/VIIc interface [polypeptide binding]; other site 717785009631 Subunit I/IV interface [polypeptide binding]; other site 717785009632 Subunit I/II interface [polypeptide binding]; other site 717785009633 Low-spin heme (heme a) binding site [chemical binding]; other site 717785009634 Subunit I/VIIa interface [polypeptide binding]; other site 717785009635 Subunit I/VIa interface [polypeptide binding]; other site 717785009636 Dimer interface; other site 717785009637 Putative water exit pathway; other site 717785009638 Binuclear center (heme a3/CuB) [ion binding]; other site 717785009639 K-pathway; other site 717785009640 Subunit I/Vb interface [polypeptide binding]; other site 717785009641 Putative proton exit pathway; other site 717785009642 Subunit I/VIb interface; other site 717785009643 Subunit I/VIc interface [polypeptide binding]; other site 717785009644 Electron transfer pathway; other site 717785009645 Subunit I/VIIIb interface [polypeptide binding]; other site 717785009646 Subunit I/VIIb interface [polypeptide binding]; other site 717785009647 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 717785009648 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 717785009649 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785009650 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785009651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785009652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785009653 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785009654 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785009655 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 717785009656 putative metal binding site [ion binding]; other site 717785009657 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 717785009658 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 717785009659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 717785009660 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785009661 Walker A/P-loop; other site 717785009662 ATP binding site [chemical binding]; other site 717785009663 Q-loop/lid; other site 717785009664 ABC transporter signature motif; other site 717785009665 Walker B; other site 717785009666 D-loop; other site 717785009667 H-loop/switch region; other site 717785009668 DevC protein; Region: devC; TIGR01185 717785009669 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 717785009670 FtsX-like permease family; Region: FtsX; pfam02687 717785009671 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 717785009672 Esterase/lipase [General function prediction only]; Region: COG1647 717785009673 aminodeoxychorismate synthase; Provisional; Region: PRK07508 717785009674 chorismate binding enzyme; Region: Chorismate_bind; cl10555 717785009675 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 717785009676 substrate-cofactor binding pocket; other site 717785009677 homodimer interface [polypeptide binding]; other site 717785009678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785009679 catalytic residue [active] 717785009680 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 717785009681 nudix motif; other site 717785009682 Protein of unknown function (DUF763); Region: DUF763; cl00620 717785009683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 717785009684 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 717785009685 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 717785009686 Walker A/P-loop; other site 717785009687 ATP binding site [chemical binding]; other site 717785009688 Q-loop/lid; other site 717785009689 ABC transporter signature motif; other site 717785009690 Walker B; other site 717785009691 D-loop; other site 717785009692 H-loop/switch region; other site 717785009693 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 717785009694 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 717785009695 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 717785009696 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 717785009697 putative ADP-binding pocket [chemical binding]; other site 717785009698 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 717785009699 Bacterial SH3 domain; Region: SH3_3; cl02551 717785009700 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 717785009701 active site 717785009702 Int/Topo IB signature motif; other site 717785009703 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 717785009704 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 717785009705 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 717785009706 polymerase nucleotide-binding site; other site 717785009707 DNA-binding residues [nucleotide binding]; DNA binding site 717785009708 nucleotide binding site [chemical binding]; other site 717785009709 primase nucleotide-binding site [nucleotide binding]; other site 717785009710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785009711 Walker A motif; other site 717785009712 ATP binding site [chemical binding]; other site 717785009713 Walker B motif; other site 717785009714 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 717785009715 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 717785009716 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 717785009717 Phage-related minor tail protein [Function unknown]; Region: COG5281 717785009718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785009719 non-specific DNA binding site [nucleotide binding]; other site 717785009720 salt bridge; other site 717785009721 sequence-specific DNA binding site [nucleotide binding]; other site 717785009722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 717785009723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785009724 putative substrate translocation pore; other site 717785009725 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 717785009726 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 717785009727 putative NAD(P) binding site [chemical binding]; other site 717785009728 putative substrate binding site [chemical binding]; other site 717785009729 catalytic Zn binding site [ion binding]; other site 717785009730 structural Zn binding site [ion binding]; other site 717785009731 dimer interface [polypeptide binding]; other site 717785009732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785009733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785009734 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 717785009735 putative effector binding pocket; other site 717785009736 putative dimerization interface [polypeptide binding]; other site 717785009737 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785009738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785009739 active site 717785009740 catalytic tetrad [active] 717785009741 Protein of unknown function (DUF512); Region: DUF512; pfam04459 717785009742 dihydropteroate synthase-related protein; Region: TIGR00284 717785009743 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 717785009744 substrate binding pocket [chemical binding]; other site 717785009745 dimer interface [polypeptide binding]; other site 717785009746 inhibitor binding site; inhibition site 717785009747 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785009748 LysR family transcriptional regulator; Provisional; Region: PRK14997 717785009749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785009750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785009751 putative effector binding pocket; other site 717785009752 dimerization interface [polypeptide binding]; other site 717785009753 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785009754 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 717785009755 Zn binding site [ion binding]; other site 717785009756 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 717785009757 Zn binding site [ion binding]; other site 717785009758 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785009759 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 717785009760 Flavin Reductases; Region: FlaRed; cl00801 717785009761 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 717785009762 dimerization interface [polypeptide binding]; other site 717785009763 DPS ferroxidase diiron center [ion binding]; other site 717785009764 ion pore; other site 717785009765 Domain of unknown function DUF302; Region: DUF302; cl01364 717785009766 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 717785009767 classical (c) SDRs; Region: SDR_c; cd05233 717785009768 NAD(P) binding site [chemical binding]; other site 717785009769 active site 717785009770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785009771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785009772 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 717785009773 CoenzymeA binding site [chemical binding]; other site 717785009774 subunit interaction site [polypeptide binding]; other site 717785009775 PHB binding site; other site 717785009776 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 717785009777 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 717785009778 dimer interface [polypeptide binding]; other site 717785009779 active site 717785009780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785009781 dimer interface [polypeptide binding]; other site 717785009782 conserved gate region; other site 717785009783 putative PBP binding loops; other site 717785009784 ABC-ATPase subunit interface; other site 717785009785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 717785009786 dimer interface [polypeptide binding]; other site 717785009787 conserved gate region; other site 717785009788 putative PBP binding loops; other site 717785009789 ABC-ATPase subunit interface; other site 717785009790 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 717785009791 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 717785009792 Walker A/P-loop; other site 717785009793 ATP binding site [chemical binding]; other site 717785009794 Q-loop/lid; other site 717785009795 ABC transporter signature motif; other site 717785009796 Walker B; other site 717785009797 D-loop; other site 717785009798 H-loop/switch region; other site 717785009799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009800 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 717785009801 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 717785009802 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 717785009803 catalytic triad [active] 717785009804 Sulfatase; Region: Sulfatase; cl10460 717785009805 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 717785009806 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 717785009807 ligand binding site [chemical binding]; other site 717785009808 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 717785009809 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 717785009810 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 717785009811 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 717785009812 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 717785009813 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 717785009814 Rod binding protein; Region: Rod-binding; cl01626 717785009815 CheD chemotactic sensory transduction; Region: CheD; cl00810 717785009816 Response regulator receiver domain; Region: Response_reg; pfam00072 717785009817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009818 active site 717785009819 phosphorylation site [posttranslational modification] 717785009820 intermolecular recognition site; other site 717785009821 dimerization interface [polypeptide binding]; other site 717785009822 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 717785009823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009824 active site 717785009825 phosphorylation site [posttranslational modification] 717785009826 intermolecular recognition site; other site 717785009827 dimerization interface [polypeptide binding]; other site 717785009828 CheB methylesterase; Region: CheB_methylest; pfam01339 717785009829 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785009830 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 717785009831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785009832 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 717785009833 putative CheA interaction surface; other site 717785009834 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 717785009835 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785009836 putative binding surface; other site 717785009837 active site 717785009838 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 717785009839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009840 ATP binding site [chemical binding]; other site 717785009841 Mg2+ binding site [ion binding]; other site 717785009842 G-X-G motif; other site 717785009843 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 717785009844 Response regulator receiver domain; Region: Response_reg; pfam00072 717785009845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009846 active site 717785009847 phosphorylation site [posttranslational modification] 717785009848 intermolecular recognition site; other site 717785009849 dimerization interface [polypeptide binding]; other site 717785009850 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 717785009851 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 717785009852 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785009853 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 717785009854 PilZ domain; Region: PilZ; cl01260 717785009855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 717785009856 PAS fold; Region: PAS_3; pfam08447 717785009857 putative active site [active] 717785009858 heme pocket [chemical binding]; other site 717785009859 PAS fold; Region: PAS_7; pfam12860 717785009860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009861 metal binding site [ion binding]; metal-binding site 717785009862 active site 717785009863 I-site; other site 717785009864 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785009865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785009866 metal binding site [ion binding]; metal-binding site 717785009867 active site 717785009868 I-site; other site 717785009869 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 717785009870 Flagellar hook capping protein; Region: FlgD; cl04347 717785009871 Flagellar protein FlbT; Region: FlbT; cl11455 717785009872 Flagellar protein FlaF; Region: FlaF; cl11454 717785009873 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717785009874 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 717785009875 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717785009876 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 717785009877 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 717785009878 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 717785009879 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 717785009880 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 717785009881 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 717785009882 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 717785009883 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785009884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 717785009885 DNA binding site [nucleotide binding] 717785009886 chemotaxis protein; Reviewed; Region: PRK12798 717785009887 flagellar motor protein MotB; Validated; Region: motB; PRK05996 717785009888 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 717785009889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785009890 ligand binding site [chemical binding]; other site 717785009891 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 717785009892 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 717785009893 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 717785009894 flagellin; Reviewed; Region: PRK12687 717785009895 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 717785009896 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 717785009897 FliP family; Region: FliP; cl00593 717785009898 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 717785009899 Flagellar L-ring protein; Region: FlgH; cl00905 717785009900 MgtE intracellular N domain; Region: MgtE_N; cl15244 717785009901 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 717785009902 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 717785009903 SAF domain; Region: SAF; cl00555 717785009904 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 717785009905 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 717785009906 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 717785009907 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 717785009908 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 717785009909 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 717785009910 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 717785009911 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 717785009912 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 717785009913 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 717785009914 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 717785009915 FliG C-terminal domain; Region: FliG_C; pfam01706 717785009916 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 717785009917 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 717785009918 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 717785009919 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 717785009920 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 717785009921 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 717785009922 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 717785009923 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 717785009924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785009925 Walker A motif; other site 717785009926 ATP binding site [chemical binding]; other site 717785009927 Walker B motif; other site 717785009928 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 717785009929 catalytic residue [active] 717785009930 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 717785009931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 717785009932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 717785009933 FOG: CBS domain [General function prediction only]; Region: COG0517 717785009934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 717785009935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785009936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785009937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 717785009938 dimerization interface [polypeptide binding]; other site 717785009939 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 717785009940 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 717785009941 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 717785009942 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 717785009943 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 717785009944 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 717785009945 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 717785009946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785009947 non-specific DNA binding site [nucleotide binding]; other site 717785009948 salt bridge; other site 717785009949 sequence-specific DNA binding site [nucleotide binding]; other site 717785009950 Cupin domain; Region: Cupin_2; cl09118 717785009951 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 717785009952 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 717785009953 putative active site [active] 717785009954 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 717785009955 domain_subunit interface; other site 717785009956 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 717785009957 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 717785009958 active site 717785009959 FMN binding site [chemical binding]; other site 717785009960 substrate binding site [chemical binding]; other site 717785009961 3Fe-4S cluster binding site [ion binding]; other site 717785009962 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 717785009963 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 717785009964 Uncharacterized conserved protein [Function unknown]; Region: COG3287 717785009965 FIST N domain; Region: FIST; pfam08495 717785009966 FIST C domain; Region: FIST_C; pfam10442 717785009967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785009968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 717785009969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785009970 ATP binding site [chemical binding]; other site 717785009971 Mg2+ binding site [ion binding]; other site 717785009972 G-X-G motif; other site 717785009973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009974 active site 717785009975 phosphorylation site [posttranslational modification] 717785009976 intermolecular recognition site; other site 717785009977 dimerization interface [polypeptide binding]; other site 717785009978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785009979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785009980 active site 717785009981 phosphorylation site [posttranslational modification] 717785009982 intermolecular recognition site; other site 717785009983 dimerization interface [polypeptide binding]; other site 717785009984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785009985 DNA binding residues [nucleotide binding] 717785009986 dimerization interface [polypeptide binding]; other site 717785009987 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 717785009988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785009989 nucleotide binding region [chemical binding]; other site 717785009990 ATP-binding site [chemical binding]; other site 717785009991 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 717785009992 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 717785009993 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 717785009994 substrate binding site [chemical binding]; other site 717785009995 hexamer interface [polypeptide binding]; other site 717785009996 metal binding site [ion binding]; metal-binding site 717785009997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785009998 Active site [active] 717785009999 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 717785010000 AMP binding site [chemical binding]; other site 717785010001 metal binding site [ion binding]; metal-binding site 717785010002 active site 717785010003 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 717785010004 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765 717785010005 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 717785010006 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785010007 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785010008 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 717785010009 Uncharacterized conserved protein [Function unknown]; Region: COG2308 717785010010 Domain of unknown function (DUF404); Region: DUF404; pfam04169 717785010011 Domain of unknown function (DUF407); Region: DUF407; pfam04174 717785010012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 717785010014 putative substrate translocation pore; other site 717785010015 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 717785010016 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 717785010017 Potassium binding sites [ion binding]; other site 717785010018 Cesium cation binding sites [ion binding]; other site 717785010019 Ion channel; Region: Ion_trans_2; cl11596 717785010020 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785010021 ligand binding site [chemical binding]; other site 717785010022 flexible hinge region; other site 717785010023 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 717785010024 Active site [active] 717785010025 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 717785010026 phosphopeptide binding site; other site 717785010027 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 717785010028 phosphopeptide binding site; other site 717785010029 Catalytic domain of Protein Kinases; Region: PKc; cd00180 717785010030 active site 717785010031 ATP binding site [chemical binding]; other site 717785010032 substrate binding site [chemical binding]; other site 717785010033 activation loop (A-loop); other site 717785010034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 717785010035 structural tetrad; other site 717785010036 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785010037 Catalytic site; other site 717785010038 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 717785010039 putative di-iron ligands [ion binding]; other site 717785010040 HemK family putative methylases; Region: hemK_fam; TIGR00536 717785010041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785010042 S-adenosylmethionine binding site [chemical binding]; other site 717785010043 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 717785010044 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 717785010045 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 717785010046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785010047 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010048 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 717785010049 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785010050 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010051 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785010052 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 717785010053 homodimer interface [polypeptide binding]; other site 717785010054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010055 catalytic residue [active] 717785010056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785010057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010058 active site 717785010059 phosphorylation site [posttranslational modification] 717785010060 intermolecular recognition site; other site 717785010061 dimerization interface [polypeptide binding]; other site 717785010062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785010063 dimerization interface [polypeptide binding]; other site 717785010064 DNA binding residues [nucleotide binding] 717785010065 Fusaric acid resistance protein family; Region: FUSC; pfam04632 717785010066 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 717785010067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785010068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785010069 Surface antigen; Region: Surface_Ag_2; cl01155 717785010070 Staphylococcal nuclease homologues; Region: SNc; smart00318 717785010071 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 717785010072 Catalytic site; other site 717785010073 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 717785010074 Ferredoxin [Energy production and conversion]; Region: COG1146 717785010075 4Fe-4S binding domain; Region: Fer4; cl02805 717785010076 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 717785010077 Ribosomal protein S4 and related proteins [Translation, ribosomal structure and biogenesis]; Region: RpsD; COG0522 717785010078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 717785010079 RNA binding surface [nucleotide binding]; other site 717785010080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 717785010081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 717785010082 nucleotide binding region [chemical binding]; other site 717785010083 ATP-binding site [chemical binding]; other site 717785010084 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 717785010085 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 717785010086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 717785010087 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 717785010088 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 717785010089 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 717785010090 metal ion-dependent adhesion site (MIDAS); other site 717785010091 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 717785010092 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 717785010093 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785010094 HSP70 interaction site [polypeptide binding]; other site 717785010095 BolA-like protein; Region: BolA; cl00386 717785010096 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 717785010097 Domain of unknown function DUF21; Region: DUF21; pfam01595 717785010098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785010099 Transporter associated domain; Region: CorC_HlyC; pfam03471 717785010100 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 717785010101 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 717785010102 ADP binding site [chemical binding]; other site 717785010103 magnesium binding site [ion binding]; other site 717785010104 putative shikimate binding site; other site 717785010105 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 717785010106 active site 717785010107 dimer interface [polypeptide binding]; other site 717785010108 metal binding site [ion binding]; metal-binding site 717785010109 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 717785010110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785010111 DNA binding site [nucleotide binding] 717785010112 Int/Topo IB signature motif; other site 717785010113 active site 717785010114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 717785010115 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 717785010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785010117 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 717785010118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785010119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785010120 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 717785010121 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 717785010122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 717785010123 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 717785010124 hypothetical protein; Provisional; Region: PRK05590 717785010125 SEC-C motif; Region: SEC-C; cl12132 717785010126 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 717785010127 PPIC-type PPIASE domain; Region: Rotamase; cl08278 717785010128 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 717785010129 heterotetramer interface [polypeptide binding]; other site 717785010130 active site pocket [active] 717785010131 cleavage site 717785010132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785010133 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 717785010134 active site 717785010135 8-oxo-dGMP binding site [chemical binding]; other site 717785010136 nudix motif; other site 717785010137 metal binding site [ion binding]; metal-binding site 717785010138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785010139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785010140 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 717785010141 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 717785010142 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 717785010143 GSH binding site [chemical binding]; other site 717785010144 catalytic residues [active] 717785010145 Predicted amidohydrolase [General function prediction only]; Region: COG0388 717785010146 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 717785010147 putative active site [active] 717785010148 catalytic triad [active] 717785010149 dimer interface [polypeptide binding]; other site 717785010150 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 717785010151 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 717785010152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785010153 FeS/SAM binding site; other site 717785010154 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 717785010155 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 717785010156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 717785010157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 717785010158 catalytic residue [active] 717785010159 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 717785010160 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 717785010161 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 717785010162 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 717785010163 inhibitor-cofactor binding pocket; inhibition site 717785010164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010165 catalytic residue [active] 717785010166 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 717785010167 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785010168 dimer interface [polypeptide binding]; other site 717785010169 active site 717785010170 CoA binding pocket [chemical binding]; other site 717785010171 YceI-like domain; Region: YceI; cl01001 717785010172 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 717785010173 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785010174 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785010175 Uncharacterized conserved protein [Function unknown]; Region: COG2308 717785010176 Domain of unknown function (DUF404); Region: DUF404; pfam04169 717785010177 Domain of unknown function (DUF407); Region: DUF407; pfam04174 717785010178 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 717785010179 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 717785010180 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 717785010181 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 717785010182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 717785010183 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 717785010184 Hemin uptake protein hemP; Region: hemP; cl10043 717785010185 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 717785010186 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 717785010187 putative hemin binding site; other site 717785010188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 717785010189 ABC-ATPase subunit interface; other site 717785010190 dimer interface [polypeptide binding]; other site 717785010191 putative PBP binding regions; other site 717785010192 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 717785010193 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 717785010194 Walker A/P-loop; other site 717785010195 ATP binding site [chemical binding]; other site 717785010196 Q-loop/lid; other site 717785010197 ABC transporter signature motif; other site 717785010198 Walker B; other site 717785010199 D-loop; other site 717785010200 H-loop/switch region; other site 717785010201 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 717785010202 active site 717785010203 metal binding site [ion binding]; metal-binding site 717785010204 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 717785010205 ChuX-like family; Region: DUF1008; cl01509 717785010206 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 717785010207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010208 ATP binding site [chemical binding]; other site 717785010209 Mg2+ binding site [ion binding]; other site 717785010210 G-X-G motif; other site 717785010211 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 717785010212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010213 active site 717785010214 phosphorylation site [posttranslational modification] 717785010215 intermolecular recognition site; other site 717785010216 dimerization interface [polypeptide binding]; other site 717785010217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785010218 DNA binding site [nucleotide binding] 717785010219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010220 Uncharacterized conserved protein [Function unknown]; Region: COG1432 717785010221 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 717785010222 putative metal binding site [ion binding]; other site 717785010223 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 717785010224 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785010225 YeeE/YedE family (DUF395); Region: DUF395; cl01018 717785010226 Curli production assembly/transport component CsgF; Region: Tafi-CsgF; cl08082 717785010227 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 717785010228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 717785010229 Predicted integral membrane protein [Function unknown]; Region: COG0392 717785010230 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 717785010231 Uncharacterized conserved protein [Function unknown]; Region: COG2898 717785010232 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 717785010233 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 717785010234 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 717785010235 PilZ domain; Region: PilZ; cl01260 717785010236 Response regulator receiver domain; Region: Response_reg; pfam00072 717785010237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010238 active site 717785010239 phosphorylation site [posttranslational modification] 717785010240 intermolecular recognition site; other site 717785010241 dimerization interface [polypeptide binding]; other site 717785010242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 717785010243 metal binding site [ion binding]; metal-binding site 717785010244 active site 717785010245 I-site; other site 717785010246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 717785010247 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 717785010248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010249 active site 717785010250 phosphorylation site [posttranslational modification] 717785010251 intermolecular recognition site; other site 717785010252 dimerization interface [polypeptide binding]; other site 717785010253 CheB methylesterase; Region: CheB_methylest; pfam01339 717785010254 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 717785010255 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 717785010256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785010257 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 717785010258 putative CheA interaction surface; other site 717785010259 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 717785010260 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 717785010261 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 717785010262 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 717785010263 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 717785010264 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 717785010265 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 717785010266 putative binding surface; other site 717785010267 active site 717785010268 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 717785010269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010270 ATP binding site [chemical binding]; other site 717785010271 Mg2+ binding site [ion binding]; other site 717785010272 G-X-G motif; other site 717785010273 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 717785010274 Response regulator receiver domain; Region: Response_reg; pfam00072 717785010275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010276 active site 717785010277 phosphorylation site [posttranslational modification] 717785010278 intermolecular recognition site; other site 717785010279 dimerization interface [polypeptide binding]; other site 717785010280 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 717785010281 mce related protein; Region: MCE; cl03606 717785010282 Protein of unknown function (DUF330); Region: DUF330; cl01135 717785010283 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 717785010284 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 717785010285 Walker A/P-loop; other site 717785010286 ATP binding site [chemical binding]; other site 717785010287 Q-loop/lid; other site 717785010288 ABC transporter signature motif; other site 717785010289 Walker B; other site 717785010290 D-loop; other site 717785010291 H-loop/switch region; other site 717785010292 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 717785010293 anti sigma factor interaction site; other site 717785010294 regulatory phosphorylation site [posttranslational modification]; other site 717785010295 Domain of unknown function DUF140; Region: DUF140; cl00510 717785010296 YGGT family; Region: YGGT; cl00508 717785010297 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 717785010298 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 717785010299 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 717785010300 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 717785010301 homodimer interface [polypeptide binding]; other site 717785010302 NADP binding site [chemical binding]; other site 717785010303 substrate binding site [chemical binding]; other site 717785010304 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 717785010305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785010306 Walker A motif; other site 717785010307 ATP binding site [chemical binding]; other site 717785010308 Walker B motif; other site 717785010309 arginine finger; other site 717785010310 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 717785010311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 717785010312 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 717785010313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 717785010314 active site 717785010315 glutathione synthetase; Provisional; Region: PRK05246 717785010316 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 717785010317 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785010318 primosome assembly protein PriA; Validated; Region: PRK05580 717785010319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 717785010320 ATP binding site [chemical binding]; other site 717785010321 putative Mg++ binding site [ion binding]; other site 717785010322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 717785010323 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 717785010324 active site 717785010325 intersubunit interactions; other site 717785010326 catalytic residue [active] 717785010327 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 717785010328 FAD binding domain; Region: FAD_binding_4; pfam01565 717785010329 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 717785010330 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 717785010331 DNA binding site [nucleotide binding] 717785010332 Int/Topo IB signature motif; other site 717785010333 active site 717785010334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 717785010335 TraB family; Region: TraB; cl12050 717785010336 Predicted outer membrane protein [Function unknown]; Region: COG3652 717785010337 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 717785010338 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 717785010339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010341 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785010342 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 717785010343 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 717785010344 E3 interaction surface; other site 717785010345 lipoyl attachment site [posttranslational modification]; other site 717785010346 e3 binding domain; Region: E3_binding; pfam02817 717785010347 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 717785010348 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 717785010349 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 717785010350 TPP-binding site [chemical binding]; other site 717785010351 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 717785010352 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 717785010353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785010354 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010355 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 717785010356 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 717785010357 CoA-ligase; Region: Ligase_CoA; pfam00549 717785010358 malate dehydrogenase; Reviewed; Region: PRK06223 717785010359 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 717785010360 NAD(P) binding site [chemical binding]; other site 717785010361 dimer interface [polypeptide binding]; other site 717785010362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 717785010363 substrate binding site [chemical binding]; other site 717785010364 Predicted ATPase [General function prediction only]; Region: COG1485 717785010365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785010366 NlpC/P60 family; Region: NLPC_P60; cl11438 717785010367 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 717785010368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 717785010369 active site 717785010370 catalytic tetrad [active] 717785010371 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 717785010372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 717785010373 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 717785010374 catalytic residue [active] 717785010375 Domain of unknown function (DUF336); Region: DUF336; cl01249 717785010376 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 717785010377 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 717785010378 HIGH motif; other site 717785010379 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785010380 active site 717785010381 KMSKS motif; other site 717785010382 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 717785010383 tRNA binding surface [nucleotide binding]; other site 717785010384 Predicted secreted (periplasmic) protein (DUF2159); Region: DUF2159; cl11572 717785010385 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 717785010386 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 717785010387 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 717785010388 substrate binding site [chemical binding]; other site 717785010389 ATP binding site [chemical binding]; other site 717785010390 pantothenate kinase; Provisional; Region: PRK05439 717785010391 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 717785010392 ATP-binding site [chemical binding]; other site 717785010393 CoA-binding site [chemical binding]; other site 717785010394 Mg2+-binding site [ion binding]; other site 717785010395 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 717785010396 ParB-like partition proteins; Region: parB_part; TIGR00180 717785010397 ParB-like nuclease domain; Region: ParBc; cl02129 717785010398 KorB domain; Region: KorB; pfam08535 717785010399 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 717785010400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785010401 P-loop; other site 717785010402 Magnesium ion binding site [ion binding]; other site 717785010403 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 717785010404 Magnesium ion binding site [ion binding]; other site 717785010405 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 717785010406 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 717785010407 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 717785010408 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 717785010409 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 717785010410 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 717785010411 G1 box; other site 717785010412 GTP/Mg2+ binding site [chemical binding]; other site 717785010413 Switch I region; other site 717785010414 G2 box; other site 717785010415 Switch II region; other site 717785010416 G3 box; other site 717785010417 G4 box; other site 717785010418 G5 box; other site 717785010419 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 717785010420 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 717785010421 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 717785010422 catalytic residues [active] 717785010423 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 717785010424 Beta-lactamase; Region: Beta-lactamase; cl01009 717785010425 transcription termination factor Rho; Provisional; Region: rho; PRK09376 717785010426 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 717785010427 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 717785010428 RNA binding site [nucleotide binding]; other site 717785010429 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 717785010430 multimer interface [polypeptide binding]; other site 717785010431 Walker A motif; other site 717785010432 ATP binding site [chemical binding]; other site 717785010433 Walker B motif; other site 717785010434 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 717785010435 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 717785010436 substrate binding site [chemical binding]; other site 717785010437 active site 717785010438 Domain of unknown function (DUF299); Region: DUF299; cl00780 717785010439 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 717785010440 active site 717785010441 dimer interface [polypeptide binding]; other site 717785010442 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 717785010443 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 717785010444 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 717785010445 shikimate binding site; other site 717785010446 NAD(P) binding site [chemical binding]; other site 717785010447 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 717785010448 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 717785010449 CoA-binding site [chemical binding]; other site 717785010450 ATP-binding [chemical binding]; other site 717785010451 Proteobacterial; Region: dnaQ_proteo; TIGR01406 717785010452 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 717785010453 active site 717785010454 substrate binding site [chemical binding]; other site 717785010455 catalytic site [active] 717785010456 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 717785010457 SecA binding site; other site 717785010458 Preprotein binding site; other site 717785010459 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 717785010460 Tim44-like domain; Region: Tim44; cl09208 717785010461 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 717785010462 MltA specific insert domain; Region: MltA; pfam03562 717785010463 3D domain; Region: 3D; cl01439 717785010464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 717785010465 Smr domain; Region: Smr; cl02619 717785010466 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 717785010467 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 717785010468 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 717785010469 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 717785010470 NAD(P) binding site [chemical binding]; other site 717785010471 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 717785010472 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 717785010473 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 717785010474 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 717785010475 active site 717785010476 catalytic triad [active] 717785010477 oxyanion hole [active] 717785010478 switch loop; other site 717785010479 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 717785010480 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 717785010481 Walker A/P-loop; other site 717785010482 ATP binding site [chemical binding]; other site 717785010483 Q-loop/lid; other site 717785010484 ABC transporter signature motif; other site 717785010485 Walker B; other site 717785010486 D-loop; other site 717785010487 H-loop/switch region; other site 717785010488 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 717785010489 FtsX-like permease family; Region: FtsX; pfam02687 717785010490 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 717785010491 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 717785010492 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 717785010493 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 717785010494 active site 717785010495 Zn binding site [ion binding]; other site 717785010496 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 717785010497 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 717785010498 aconitate hydratase; Validated; Region: PRK09277 717785010499 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 717785010500 substrate binding site [chemical binding]; other site 717785010501 ligand binding site [chemical binding]; other site 717785010502 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 717785010503 substrate binding site [chemical binding]; other site 717785010504 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 717785010505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785010506 Walker A/P-loop; other site 717785010507 ATP binding site [chemical binding]; other site 717785010508 Q-loop/lid; other site 717785010509 ABC transporter signature motif; other site 717785010510 Walker B; other site 717785010511 D-loop; other site 717785010512 H-loop/switch region; other site 717785010513 CcmB protein; Region: CcmB; cl01016 717785010514 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 717785010515 Heme exporter protein D (CcmD); Region: CcmD; cl11475 717785010516 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 717785010517 catalytic residues [active] 717785010518 central insert; other site 717785010519 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 717785010520 active site clefts [active] 717785010521 zinc binding site [ion binding]; other site 717785010522 dimer interface [polypeptide binding]; other site 717785010523 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 717785010524 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 717785010525 dimer interface [polypeptide binding]; other site 717785010526 pyridoxal binding site [chemical binding]; other site 717785010527 ATP binding site [chemical binding]; other site 717785010528 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785010529 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 717785010530 putative active site [active] 717785010531 putative catalytic site [active] 717785010532 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 717785010533 putative active site [active] 717785010534 putative catalytic site [active] 717785010535 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 717785010536 E-class dimer interface [polypeptide binding]; other site 717785010537 P-class dimer interface [polypeptide binding]; other site 717785010538 active site 717785010539 Cu2+ binding site [ion binding]; other site 717785010540 Zn2+ binding site [ion binding]; other site 717785010541 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 717785010542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010543 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 717785010544 Iron-sulfur protein interface; other site 717785010545 proximal quinone binding site [chemical binding]; other site 717785010546 SdhD (CybS) interface [polypeptide binding]; other site 717785010547 proximal heme binding site [chemical binding]; other site 717785010548 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the...; Region: SQR_TypeC_SdhD_like; cd03495 717785010549 putative SdhC subunit interface [polypeptide binding]; other site 717785010550 putative proximal heme binding site [chemical binding]; other site 717785010551 putative Iron-sulfur protein interface [polypeptide binding]; other site 717785010552 putative proximal quinone binding site; other site 717785010553 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 717785010554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010555 domain; Region: Succ_DH_flav_C; pfam02910 717785010556 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 717785010557 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 717785010558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 717785010559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 717785010560 aspartate aminotransferase; Provisional; Region: PRK07681 717785010561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 717785010562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010563 homodimer interface [polypeptide binding]; other site 717785010564 catalytic residue [active] 717785010565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785010566 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 717785010567 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 717785010568 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 717785010569 ligand binding site [chemical binding]; other site 717785010570 flexible hinge region; other site 717785010571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 717785010572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010573 active site 717785010574 phosphorylation site [posttranslational modification] 717785010575 intermolecular recognition site; other site 717785010576 dimerization interface [polypeptide binding]; other site 717785010577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 717785010578 DNA binding site [nucleotide binding] 717785010579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 717785010580 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 717785010581 Nitrogen regulatory protein P-II; Region: P-II; cl00412 717785010582 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 717785010583 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 717785010584 active site 717785010585 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 717785010586 catalytic triad [active] 717785010587 dimer interface [polypeptide binding]; other site 717785010588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010589 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 717785010590 RimM N-terminal domain; Region: RimM; pfam01782 717785010591 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 717785010592 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 717785010593 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 717785010594 signal recognition particle protein; Provisional; Region: PRK10867 717785010595 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 717785010596 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717785010597 P loop; other site 717785010598 GTP binding site [chemical binding]; other site 717785010599 Signal peptide binding domain; Region: SRP_SPB; pfam02978 717785010600 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 717785010601 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 717785010602 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 717785010603 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 717785010604 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 717785010605 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 717785010606 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785010607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785010608 FeS/SAM binding site; other site 717785010609 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 717785010610 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 717785010611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 717785010612 P loop; other site 717785010613 GTP binding site [chemical binding]; other site 717785010614 Intracellular septation protein A; Region: IspA; cl01098 717785010615 Intracellular septation protein A; Region: IspA; cl01098 717785010616 Transcriptional regulators [Transcription]; Region: MarR; COG1846 717785010617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785010618 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 717785010619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785010620 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 717785010621 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 717785010622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 717785010623 catalytic core [active] 717785010624 dihydrodipicolinate reductase; Provisional; Region: PRK00048 717785010625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785010626 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 717785010627 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 717785010628 dimer interface [polypeptide binding]; other site 717785010629 substrate binding site [chemical binding]; other site 717785010630 metal binding sites [ion binding]; metal-binding site 717785010631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785010632 Coenzyme A binding pocket [chemical binding]; other site 717785010633 PIF1-like helicase; Region: PIF1; pfam05970 717785010634 Helicase; Region: Herpes_Helicase; pfam02689 717785010635 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 717785010636 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 717785010637 G1 box; other site 717785010638 putative GEF interaction site [polypeptide binding]; other site 717785010639 GTP/Mg2+ binding site [chemical binding]; other site 717785010640 Switch I region; other site 717785010641 G2 box; other site 717785010642 G3 box; other site 717785010643 Switch II region; other site 717785010644 G4 box; other site 717785010645 G5 box; other site 717785010646 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 717785010647 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 717785010648 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 717785010649 active site 717785010650 putative substrate binding region [chemical binding]; other site 717785010651 TOBE domain; Region: TOBE_2; cl01440 717785010652 N-carbamolyputrescine amidase; Region: PLN02747 717785010653 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 717785010654 putative active site; other site 717785010655 catalytic triad [active] 717785010656 putative dimer interface [polypeptide binding]; other site 717785010657 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 717785010658 agmatine deiminase; Region: agmatine_aguA; TIGR03380 717785010659 Fic family protein [Function unknown]; Region: COG3177 717785010660 Fic/DOC family; Region: Fic; cl00960 717785010661 argininosuccinate synthase; Provisional; Region: PLN00200 717785010662 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 717785010663 ANP binding site [chemical binding]; other site 717785010664 Substrate Binding Site II [chemical binding]; other site 717785010665 Substrate Binding Site I [chemical binding]; other site 717785010666 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 717785010667 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 717785010668 putative catalytic residue [active] 717785010669 acyl-CoA synthetase; Provisional; Region: PTZ00216 717785010670 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 717785010671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785010672 FeS/SAM binding site; other site 717785010673 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 717785010674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785010675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785010676 Walker A motif; other site 717785010677 ATP binding site [chemical binding]; other site 717785010678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 717785010679 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785010680 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 717785010681 active site 717785010682 HslU subunit interaction site [polypeptide binding]; other site 717785010683 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 717785010684 putative active site pocket [active] 717785010685 4-fold oligomerization interface [polypeptide binding]; other site 717785010686 metal binding residues [ion binding]; metal-binding site 717785010687 3-fold/trimer interface [polypeptide binding]; other site 717785010688 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 717785010689 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 717785010690 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 717785010691 putative active site [active] 717785010692 oxyanion strand; other site 717785010693 catalytic triad [active] 717785010694 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 717785010695 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 717785010696 catalytic residues [active] 717785010697 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 717785010698 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 717785010699 G1 box; other site 717785010700 putative GEF interaction site [polypeptide binding]; other site 717785010701 GTP/Mg2+ binding site [chemical binding]; other site 717785010702 Switch I region; other site 717785010703 G2 box; other site 717785010704 G3 box; other site 717785010705 Switch II region; other site 717785010706 G4 box; other site 717785010707 G5 box; other site 717785010708 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 717785010709 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 717785010710 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 717785010711 substrate binding site [chemical binding]; other site 717785010712 glutamase interaction surface [polypeptide binding]; other site 717785010713 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 717785010714 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785010715 minor groove reading motif; other site 717785010716 helix-hairpin-helix signature motif; other site 717785010717 substrate binding pocket [chemical binding]; other site 717785010718 active site 717785010719 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 717785010720 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 717785010721 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 717785010722 dimer interface [polypeptide binding]; other site 717785010723 active site 717785010724 metal binding site [ion binding]; metal-binding site 717785010725 glutathione binding site [chemical binding]; other site 717785010726 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 717785010727 substrate binding site [chemical binding]; other site 717785010728 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 717785010729 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 717785010730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785010731 S-adenosylmethionine binding site [chemical binding]; other site 717785010732 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 717785010733 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 717785010734 substrate binding site [chemical binding]; other site 717785010735 ligand binding site [chemical binding]; other site 717785010736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785010737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785010738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 717785010739 putative effector binding pocket; other site 717785010740 dimerization interface [polypeptide binding]; other site 717785010741 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 717785010742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785010743 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 717785010744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785010745 putative substrate translocation pore; other site 717785010746 hypothetical protein; Reviewed; Region: PRK00024 717785010747 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 717785010748 MPN+ (JAMM) motif; other site 717785010749 Zinc-binding site [ion binding]; other site 717785010750 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 717785010751 methionine aminopeptidase; Reviewed; Region: PRK07281 717785010752 active site 717785010753 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 717785010754 Uncharacterized conserved protein [Function unknown]; Region: COG3743 717785010755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785010756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 717785010757 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 717785010758 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 717785010759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 717785010760 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 717785010761 active site 717785010762 dimer interface [polypeptide binding]; other site 717785010763 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 717785010764 chaperone protein DnaJ; Provisional; Region: PRK10767 717785010765 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 717785010766 HSP70 interaction site [polypeptide binding]; other site 717785010767 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 717785010768 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 717785010769 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 717785010770 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 717785010771 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 717785010772 dimer interface [polypeptide binding]; other site 717785010773 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 717785010774 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 717785010775 HrcA protein C terminal domain; Region: HrcA; pfam01628 717785010776 ribonuclease PH; Reviewed; Region: rph; PRK00173 717785010777 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 717785010778 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 717785010779 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 717785010780 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 717785010781 putative metal binding site [ion binding]; other site 717785010782 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 717785010783 active site 717785010784 dimerization interface [polypeptide binding]; other site 717785010785 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 717785010786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785010787 FeS/SAM binding site; other site 717785010788 HemN C-terminal region; Region: HemN_C; pfam06969 717785010789 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 717785010790 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 717785010791 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 717785010792 active site 717785010793 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 717785010794 endonuclease III; Region: ENDO3c; smart00478 717785010795 minor groove reading motif; other site 717785010796 helix-hairpin-helix signature motif; other site 717785010797 substrate binding pocket [chemical binding]; other site 717785010798 active site 717785010799 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785010800 active site 717785010801 HIGH motif; other site 717785010802 nucleotide binding site [chemical binding]; other site 717785010803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 717785010804 active site 717785010805 KMSKS motif; other site 717785010806 Predicted methyltransferases [General function prediction only]; Region: COG0313 717785010807 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 717785010808 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 717785010809 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 717785010810 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 717785010811 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 717785010812 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785010813 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 717785010814 beta subunit interaction interface [polypeptide binding]; other site 717785010815 Walker A motif; other site 717785010816 ATP binding site [chemical binding]; other site 717785010817 Walker B motif; other site 717785010818 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785010819 ATP synthase; Region: ATP-synt; cl00365 717785010820 OsmC-like protein; Region: OsmC; cl00767 717785010821 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 717785010822 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 717785010823 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 717785010824 alpha subunit interaction interface [polypeptide binding]; other site 717785010825 Walker A motif; other site 717785010826 ATP binding site [chemical binding]; other site 717785010827 Walker B motif; other site 717785010828 inhibitor binding site; inhibition site 717785010829 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 717785010830 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 717785010831 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 717785010832 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785010833 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 717785010834 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 717785010835 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 717785010836 D-pathway; other site 717785010837 Putative ubiquinol binding site [chemical binding]; other site 717785010838 Low-spin heme (heme b) binding site [chemical binding]; other site 717785010839 Putative water exit pathway; other site 717785010840 Binuclear center (heme o3/CuB) [ion binding]; other site 717785010841 K-pathway; other site 717785010842 Putative proton exit pathway; other site 717785010843 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 717785010844 Subunit I/III interface [polypeptide binding]; other site 717785010845 Subunit III/IV interface [polypeptide binding]; other site 717785010846 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 717785010847 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 717785010848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785010849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010850 ATP binding site [chemical binding]; other site 717785010851 Mg2+ binding site [ion binding]; other site 717785010852 G-X-G motif; other site 717785010853 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 717785010854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785010855 active site 717785010856 phosphorylation site [posttranslational modification] 717785010857 intermolecular recognition site; other site 717785010858 dimerization interface [polypeptide binding]; other site 717785010859 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 717785010860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785010861 dimer interface [polypeptide binding]; other site 717785010862 phosphorylation site [posttranslational modification] 717785010863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785010864 ATP binding site [chemical binding]; other site 717785010865 Mg2+ binding site [ion binding]; other site 717785010866 G-X-G motif; other site 717785010867 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 717785010868 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 717785010869 Sodium:solute symporter family; Region: SSF; cl00456 717785010870 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 717785010871 Flavoprotein; Region: Flavoprotein; cl08021 717785010872 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 717785010873 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 717785010874 trimer interface [polypeptide binding]; other site 717785010875 active site 717785010876 cysteine synthases; Region: cysKM; TIGR01136 717785010877 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 717785010878 dimer interface [polypeptide binding]; other site 717785010879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 717785010880 catalytic residue [active] 717785010881 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 717785010882 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 717785010883 ATP binding site [chemical binding]; other site 717785010884 substrate interface [chemical binding]; other site 717785010885 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 717785010886 putative substrate binding region [chemical binding]; other site 717785010887 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 717785010888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785010889 Bacterial SH3 domain; Region: SH3_3; cl02551 717785010890 Bacterial SH3 domain; Region: SH3_3; cl02551 717785010891 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785010892 metal binding site 2 [ion binding]; metal-binding site 717785010893 putative DNA binding helix; other site 717785010894 metal binding site 1 [ion binding]; metal-binding site 717785010895 dimer interface [polypeptide binding]; other site 717785010896 structural Zn2+ binding site [ion binding]; other site 717785010897 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 717785010898 active site 2 [active] 717785010899 active site 1 [active] 717785010900 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 717785010901 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 717785010902 dimer interface [polypeptide binding]; other site 717785010903 active site 717785010904 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 717785010905 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 717785010906 NAD binding site [chemical binding]; other site 717785010907 homotetramer interface [polypeptide binding]; other site 717785010908 homodimer interface [polypeptide binding]; other site 717785010909 substrate binding site [chemical binding]; other site 717785010910 active site 717785010911 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 717785010912 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 717785010913 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 717785010914 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 717785010915 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 717785010916 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 717785010917 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 717785010918 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 717785010919 putative nucleic acid binding region [nucleotide binding]; other site 717785010920 G-X-X-G motif; other site 717785010921 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 717785010922 RNA binding site [nucleotide binding]; other site 717785010923 domain interface; other site 717785010924 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 717785010925 16S/18S rRNA binding site [nucleotide binding]; other site 717785010926 S13e-L30e interaction site [polypeptide binding]; other site 717785010927 25S rRNA binding site [nucleotide binding]; other site 717785010928 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 717785010929 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 717785010930 RNA binding site [nucleotide binding]; other site 717785010931 active site 717785010932 Ribosome-binding factor A; Region: RBFA; cl00542 717785010933 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 717785010934 translation initiation factor IF-2; Region: IF-2; TIGR00487 717785010935 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 717785010936 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 717785010937 G1 box; other site 717785010938 putative GEF interaction site [polypeptide binding]; other site 717785010939 GTP/Mg2+ binding site [chemical binding]; other site 717785010940 Switch I region; other site 717785010941 G2 box; other site 717785010942 G3 box; other site 717785010943 Switch II region; other site 717785010944 G4 box; other site 717785010945 G5 box; other site 717785010946 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 717785010947 Translation-initiation factor 2; Region: IF-2; pfam11987 717785010948 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 717785010949 hypothetical protein; Provisional; Region: PRK09190 717785010950 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 717785010951 putative RNA binding cleft [nucleotide binding]; other site 717785010952 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 717785010953 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 717785010954 NusA N-terminal domain; Region: NusA_N; pfam08529 717785010955 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 717785010956 RNA binding site [nucleotide binding]; other site 717785010957 homodimer interface [polypeptide binding]; other site 717785010958 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 717785010959 G-X-X-G motif; other site 717785010960 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 717785010961 ribosome maturation protein RimP; Reviewed; Region: PRK00092 717785010962 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 717785010963 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 717785010964 Sm1 motif; other site 717785010965 D3 - B interaction site; other site 717785010966 D1 - D2 interaction site; other site 717785010967 Hfq - Hfq interaction site; other site 717785010968 RNA binding pocket [nucleotide binding]; other site 717785010969 Sm2 motif; other site 717785010970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785010971 S-adenosylmethionine synthetase; Validated; Region: PRK05250 717785010972 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 717785010973 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 717785010974 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 717785010975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 717785010976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 717785010977 sequence-specific DNA binding site [nucleotide binding]; other site 717785010978 salt bridge; other site 717785010979 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 717785010980 putative active site [active] 717785010981 catalytic triad [active] 717785010982 putative dimer interface [polypeptide binding]; other site 717785010983 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 717785010984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 717785010985 Transporter associated domain; Region: CorC_HlyC; pfam03471 717785010986 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 717785010987 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 717785010988 PhoH-like protein; Region: PhoH; cl12134 717785010989 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 717785010990 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 717785010991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 717785010992 FeS/SAM binding site; other site 717785010993 TRAM domain; Region: TRAM; cl01282 717785010994 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 717785010995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 717785010996 putative acyl-acceptor binding pocket; other site 717785010997 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 717785010998 metal binding site 2 [ion binding]; metal-binding site 717785010999 putative DNA binding helix; other site 717785011000 metal binding site 1 [ion binding]; metal-binding site 717785011001 dimer interface [polypeptide binding]; other site 717785011002 structural Zn2+ binding site [ion binding]; other site 717785011003 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 717785011004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 717785011005 Coenzyme A binding pocket [chemical binding]; other site 717785011006 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 717785011007 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 717785011008 putative FMN binding site [chemical binding]; other site 717785011009 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 717785011010 NifU-like domain; Region: NifU; cl00484 717785011011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 717785011012 Ligand Binding Site [chemical binding]; other site 717785011013 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 717785011014 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 717785011015 active site 717785011016 HIGH motif; other site 717785011017 dimer interface [polypeptide binding]; other site 717785011018 KMSKS motif; other site 717785011019 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 717785011020 PII uridylyl-transferase; Provisional; Region: PRK05092 717785011021 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 717785011022 metal binding triad; other site 717785011023 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 717785011024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 717785011025 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 717785011026 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 717785011027 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 717785011028 MutS domain I; Region: MutS_I; pfam01624 717785011029 MutS domain II; Region: MutS_II; pfam05188 717785011030 MutS family domain IV; Region: MutS_IV; pfam05190 717785011031 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 717785011032 Walker A/P-loop; other site 717785011033 ATP binding site [chemical binding]; other site 717785011034 Q-loop/lid; other site 717785011035 ABC transporter signature motif; other site 717785011036 Walker B; other site 717785011037 D-loop; other site 717785011038 H-loop/switch region; other site 717785011039 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 717785011040 Malic enzyme, N-terminal domain; Region: malic; pfam00390 717785011041 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 717785011042 putative NAD(P) binding site [chemical binding]; other site 717785011043 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 717785011044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 717785011045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 717785011046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785011047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785011048 dimer interface [polypeptide binding]; other site 717785011049 phosphorylation site [posttranslational modification] 717785011050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011051 ATP binding site [chemical binding]; other site 717785011052 Mg2+ binding site [ion binding]; other site 717785011053 G-X-G motif; other site 717785011054 Response regulator receiver domain; Region: Response_reg; pfam00072 717785011055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785011056 active site 717785011057 phosphorylation site [posttranslational modification] 717785011058 intermolecular recognition site; other site 717785011059 dimerization interface [polypeptide binding]; other site 717785011060 Trm112p-like protein; Region: Trm112p; cl01066 717785011061 Found in ATP-dependent protease La (LON); Region: LON; cl01056 717785011062 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 717785011063 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 717785011064 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 717785011065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 717785011066 TPR motif; other site 717785011067 binding surface 717785011068 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 717785011069 putative deacylase active site [active] 717785011070 LemA family; Region: LemA; cl00742 717785011071 Domain of unknown function (DUF477); Region: DUF477; cl01535 717785011072 Domain of unknown function (DUF477); Region: DUF477; cl01535 717785011073 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 717785011074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011075 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 717785011076 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 717785011077 purine monophosphate binding site [chemical binding]; other site 717785011078 dimer interface [polypeptide binding]; other site 717785011079 putative catalytic residues [active] 717785011080 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 717785011081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 717785011082 Heparinase II/III-like protein; Region: Hepar_II_III; cl02215 717785011083 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 717785011084 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 717785011085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785011086 S-adenosylmethionine binding site [chemical binding]; other site 717785011087 Peptidase family M48; Region: Peptidase_M48; cl12018 717785011088 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 717785011089 acetyl-CoA synthetase; Provisional; Region: PRK00174 717785011090 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 717785011091 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785011092 Predicted methyltransferase [General function prediction only]; Region: COG3897 717785011093 EVE domain; Region: EVE; cl00728 717785011094 GtrA-like protein; Region: GtrA; cl00971 717785011095 hypothetical protein; Provisional; Region: PRK07208 717785011096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785011097 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 717785011098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785011099 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 717785011100 UGMP family protein; Validated; Region: PRK09604 717785011101 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 717785011102 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 717785011103 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 717785011104 domain interfaces; other site 717785011105 active site 717785011106 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 717785011107 active site 717785011108 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 717785011109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 717785011110 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 717785011111 HemY protein N-terminus; Region: HemY_N; pfam07219 717785011112 PilZ domain; Region: PilZ; cl01260 717785011113 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 717785011114 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 717785011115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 717785011116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785011117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 717785011118 dimerization interface [polypeptide binding]; other site 717785011119 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 717785011120 ligand binding site [chemical binding]; other site 717785011121 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 717785011122 Protein of unknown function (DUF692); Region: DUF692; cl01263 717785011123 hypothetical protein; Provisional; Region: PRK05409 717785011124 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 717785011125 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 717785011126 catalytic residues [active] 717785011127 DoxX; Region: DoxX; cl00976 717785011128 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 717785011129 classical (c) SDRs; Region: SDR_c; cd05233 717785011130 NAD(P) binding site [chemical binding]; other site 717785011131 active site 717785011132 Esterase/lipase [General function prediction only]; Region: COG1647 717785011133 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 717785011134 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 717785011135 dimer interface [polypeptide binding]; other site 717785011136 active site 717785011137 CoA binding pocket [chemical binding]; other site 717785011138 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 717785011139 Response regulator receiver domain; Region: Response_reg; pfam00072 717785011140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785011141 active site 717785011142 phosphorylation site [posttranslational modification] 717785011143 intermolecular recognition site; other site 717785011144 dimerization interface [polypeptide binding]; other site 717785011145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 717785011146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785011147 active site 717785011148 phosphorylation site [posttranslational modification] 717785011149 intermolecular recognition site; other site 717785011150 dimerization interface [polypeptide binding]; other site 717785011151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 717785011152 DNA binding residues [nucleotide binding] 717785011153 dimerization interface [polypeptide binding]; other site 717785011154 two-component sensor protein; Provisional; Region: cpxA; PRK09470 717785011155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 717785011156 dimer interface [polypeptide binding]; other site 717785011157 phosphorylation site [posttranslational modification] 717785011158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011159 ATP binding site [chemical binding]; other site 717785011160 Mg2+ binding site [ion binding]; other site 717785011161 G-X-G motif; other site 717785011162 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 717785011163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 717785011164 active site 717785011165 phosphorylation site [posttranslational modification] 717785011166 intermolecular recognition site; other site 717785011167 dimerization interface [polypeptide binding]; other site 717785011168 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 717785011169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785011170 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 717785011171 dimerization interface [polypeptide binding]; other site 717785011172 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 717785011173 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 717785011174 catalytic residue [active] 717785011175 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 717785011176 catalytic residues [active] 717785011177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785011178 peroxiredoxin; Region: AhpC; TIGR03137 717785011179 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 717785011180 dimer interface [polypeptide binding]; other site 717785011181 decamer (pentamer of dimers) interface [polypeptide binding]; other site 717785011182 catalytic triad [active] 717785011183 peroxidatic and resolving cysteines [active] 717785011184 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 717785011185 Moco binding site; other site 717785011186 metal coordination site [ion binding]; other site 717785011187 allantoate amidohydrolase; Reviewed; Region: PRK09290 717785011188 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 717785011189 active site 717785011190 metal binding site [ion binding]; metal-binding site 717785011191 dimer interface [polypeptide binding]; other site 717785011192 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 717785011193 nucleoside/Zn binding site; other site 717785011194 dimer interface [polypeptide binding]; other site 717785011195 catalytic motif [active] 717785011196 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 717785011197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785011198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 717785011199 Cytochrome c; Region: Cytochrom_C; cl11414 717785011200 Cytochrome c; Region: Cytochrom_C; cl11414 717785011201 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 717785011202 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 717785011203 Trp docking motif; other site 717785011204 'Velcro' closure; other site 717785011205 active site 717785011206 Cytochrome c; Region: Cytochrom_C; cl11414 717785011207 Cytochrome c; Region: Cytochrom_C; cl11414 717785011208 Secretory lipase; Region: LIP; pfam03583 717785011209 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 717785011210 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 717785011211 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 717785011212 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 717785011213 CGNR zinc finger; Region: zf-CGNR; pfam11706 717785011214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785011215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 717785011216 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 717785011217 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 717785011218 putative NAD(P) binding site [chemical binding]; other site 717785011219 mercuric reductase; Validated; Region: PRK06370 717785011220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785011221 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785011222 RNA polymerase sigma factor; Provisional; Region: PRK12512 717785011223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 717785011224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 717785011225 DNA binding residues [nucleotide binding] 717785011226 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 717785011227 CGNR zinc finger; Region: zf-CGNR; pfam11706 717785011228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 717785011229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 717785011230 ATP binding site [chemical binding]; other site 717785011231 Mg2+ binding site [ion binding]; other site 717785011232 G-X-G motif; other site 717785011233 mercuric reductase; Validated; Region: PRK06370 717785011234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 717785011235 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 717785011236 Ribonuclease P; Region: Ribonuclease_P; cl00457 717785011237 membrane protein insertase; Provisional; Region: PRK01318 717785011238 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 717785011239 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 717785011240 G1 box; other site 717785011241 GTP/Mg2+ binding site [chemical binding]; other site 717785011242 Switch I region; other site 717785011243 G2 box; other site 717785011244 G3 box; other site 717785011245 Switch II region; other site 717785011246 G4 box; other site 717785011247 G5 box; other site 717785011248 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 717785011249 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 717785011250 feedback inhibition sensing region; other site 717785011251 homohexameric interface [polypeptide binding]; other site 717785011252 nucleotide binding site [chemical binding]; other site 717785011253 N-acetyl-L-glutamate binding site [chemical binding]; other site 717785011254 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 717785011255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 717785011256 motif II; other site 717785011257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 717785011258 classical (c) SDRs; Region: SDR_c; cd05233 717785011259 NAD(P) binding site [chemical binding]; other site 717785011260 active site 717785011261 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 717785011262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785011263 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 717785011264 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 717785011265 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 717785011266 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 717785011267 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 717785011268 Ligand binding site [chemical binding]; other site 717785011269 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 717785011270 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 717785011271 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 717785011272 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785011273 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 717785011274 C-terminal peptidase (prc); Region: prc; TIGR00225 717785011275 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 717785011276 protein binding site [polypeptide binding]; other site 717785011277 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 717785011278 Catalytic dyad [active] 717785011279 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 717785011280 putative active site [active] 717785011281 Ap4A binding site [chemical binding]; other site 717785011282 nudix motif; other site 717785011283 putative metal binding site [ion binding]; other site 717785011284 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 717785011285 putative active site [active] 717785011286 Ap4A binding site [chemical binding]; other site 717785011287 nudix motif; other site 717785011288 putative metal binding site [ion binding]; other site 717785011289 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 717785011290 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 717785011291 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 717785011292 metabolite-proton symporter; Region: 2A0106; TIGR00883 717785011293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011294 putative substrate translocation pore; other site 717785011295 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 717785011296 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 717785011297 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 717785011298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 717785011299 RNA polymerase Rpb8; Region: RNA_pol_Rpb8; cl02716 717785011300 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 717785011301 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 717785011302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 717785011303 putative substrate translocation pore; other site 717785011304 Rhomboid family; Region: Rhomboid; cl11446 717785011305 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 717785011306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785011307 S-adenosylmethionine binding site [chemical binding]; other site 717785011308 aspartate kinase; Reviewed; Region: PRK06635 717785011309 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 717785011310 putative nucleotide binding site [chemical binding]; other site 717785011311 putative catalytic residues [active] 717785011312 putative Mg ion binding site [ion binding]; other site 717785011313 putative aspartate binding site [chemical binding]; other site 717785011314 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 717785011315 putative allosteric regulatory site; other site 717785011316 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 717785011317 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 717785011318 GAF domain; Region: GAF; cl00853 717785011319 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 717785011320 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 717785011321 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 717785011322 peptide chain release factor 1; Validated; Region: prfA; PRK00591 717785011323 RF-1 domain; Region: RF-1; cl02875 717785011324 RF-1 domain; Region: RF-1; cl02875 717785011325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 717785011326 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 717785011327 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 717785011328 MOSC domain; Region: MOSC; pfam03473 717785011329 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 717785011330 Clp amino terminal domain; Region: Clp_N; pfam02861 717785011331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785011332 Walker A motif; other site 717785011333 ATP binding site [chemical binding]; other site 717785011334 Walker B motif; other site 717785011335 arginine finger; other site 717785011336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 717785011337 Walker A motif; other site 717785011338 ATP binding site [chemical binding]; other site 717785011339 Walker B motif; other site 717785011340 arginine finger; other site 717785011341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 717785011342 short chain dehydrogenase; Provisional; Region: PRK05693 717785011343 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 717785011344 NADP binding site [chemical binding]; other site 717785011345 active site 717785011346 steroid binding site; other site 717785011347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 717785011348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 717785011349 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 717785011350 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785011351 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 717785011352 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 717785011353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 717785011354 ligand binding site [chemical binding]; other site 717785011355 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 717785011356 Cupin domain; Region: Cupin_2; cl09118 717785011357 Cytochrome c; Region: Cytochrom_C; cl11414 717785011358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 717785011359 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 717785011360 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 717785011361 Peptidase family M23; Region: Peptidase_M23; pfam01551 717785011362 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 717785011363 Iron permease FTR1 family; Region: FTR1; cl00475 717785011364 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 717785011365 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 717785011366 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 717785011367 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 717785011368 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785011369 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785011370 ATP binding site [chemical binding]; other site 717785011371 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 717785011372 substrate binding site [chemical binding]; other site 717785011373 activation loop (A-loop); other site 717785011374 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 717785011375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 717785011376 S-adenosylmethionine binding site [chemical binding]; other site 717785011377 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 717785011378 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 717785011379 DNA binding site [nucleotide binding] 717785011380 catalytic residue [active] 717785011381 H2TH interface [polypeptide binding]; other site 717785011382 putative catalytic residues [active] 717785011383 turnover-facilitating residue; other site 717785011384 intercalation triad [nucleotide binding]; other site 717785011385 8OG recognition residue [nucleotide binding]; other site 717785011386 putative reading head residues; other site 717785011387 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 717785011388 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 717785011389 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 717785011390 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 717785011391 active site residue [active]