-- dump date 20140619_115836 -- class Genbank::misc_feature -- table misc_feature_note -- id note 945713000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 945713000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 945713000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000004 Walker A motif; other site 945713000005 ATP binding site [chemical binding]; other site 945713000006 Walker B motif; other site 945713000007 arginine finger; other site 945713000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 945713000009 DnaA box-binding interface [nucleotide binding]; other site 945713000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 945713000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 945713000012 putative DNA binding surface [nucleotide binding]; other site 945713000013 dimer interface [polypeptide binding]; other site 945713000014 beta-clamp/clamp loader binding surface; other site 945713000015 beta-clamp/translesion DNA polymerase binding surface; other site 945713000016 recombination protein F; Reviewed; Region: recF; PRK00064 945713000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713000018 Walker A/P-loop; other site 945713000019 ATP binding site [chemical binding]; other site 945713000020 Q-loop/lid; other site 945713000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713000022 ABC transporter signature motif; other site 945713000023 Walker B; other site 945713000024 D-loop; other site 945713000025 H-loop/switch region; other site 945713000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 945713000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 945713000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000029 Mg2+ binding site [ion binding]; other site 945713000030 G-X-G motif; other site 945713000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 945713000032 anchoring element; other site 945713000033 dimer interface [polypeptide binding]; other site 945713000034 ATP binding site [chemical binding]; other site 945713000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 945713000036 active site 945713000037 putative metal-binding site [ion binding]; other site 945713000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 945713000039 DNA gyrase subunit A; Validated; Region: PRK05560 945713000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 945713000041 CAP-like domain; other site 945713000042 active site 945713000043 primary dimer interface [polypeptide binding]; other site 945713000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 945713000050 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 945713000051 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 945713000052 Clp amino terminal domain; Region: Clp_N; pfam02861 945713000053 Clp amino terminal domain; Region: Clp_N; pfam02861 945713000054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000055 Walker A motif; other site 945713000056 ATP binding site [chemical binding]; other site 945713000057 Walker B motif; other site 945713000058 arginine finger; other site 945713000059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000060 Walker A motif; other site 945713000061 ATP binding site [chemical binding]; other site 945713000062 Walker B motif; other site 945713000063 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 945713000064 heat shock protein 90; Provisional; Region: PRK05218 945713000065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000066 ATP binding site [chemical binding]; other site 945713000067 Mg2+ binding site [ion binding]; other site 945713000068 G-X-G motif; other site 945713000069 chaperone protein DnaJ; Provisional; Region: PRK14299 945713000070 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 945713000071 HSP70 interaction site [polypeptide binding]; other site 945713000072 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 945713000073 substrate binding site [polypeptide binding]; other site 945713000074 dimer interface [polypeptide binding]; other site 945713000075 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 945713000076 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 945713000077 putative dimer interface [polypeptide binding]; other site 945713000078 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 945713000079 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 945713000080 trmE is a tRNA modification GTPase; Region: trmE; cd04164 945713000081 G1 box; other site 945713000082 GTP/Mg2+ binding site [chemical binding]; other site 945713000083 Switch I region; other site 945713000084 G2 box; other site 945713000085 Switch II region; other site 945713000086 G3 box; other site 945713000087 G4 box; other site 945713000088 G5 box; other site 945713000089 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 945713000090 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 945713000091 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 945713000092 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 945713000093 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 945713000094 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 945713000095 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 945713000096 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 945713000097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713000098 ATP binding site [chemical binding]; other site 945713000099 putative Mg++ binding site [ion binding]; other site 945713000100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713000101 nucleotide binding region [chemical binding]; other site 945713000102 ATP-binding site [chemical binding]; other site 945713000103 TRCF domain; Region: TRCF; pfam03461 945713000104 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 945713000105 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 945713000106 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 945713000107 ACT domain-containing protein [General function prediction only]; Region: COG4747 945713000108 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 945713000109 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 945713000110 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 945713000111 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000112 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 945713000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713000114 motif II; other site 945713000115 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 945713000116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 945713000117 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 945713000118 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 945713000119 putative active site; other site 945713000120 catalytic residue [active] 945713000121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 945713000122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 945713000123 active site 945713000124 Cupin domain; Region: Cupin_2; cl17218 945713000125 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945713000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713000127 S-adenosylmethionine binding site [chemical binding]; other site 945713000128 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 945713000129 SnoaL-like domain; Region: SnoaL_3; pfam13474 945713000130 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 945713000131 putative hydrophobic ligand binding site [chemical binding]; other site 945713000132 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 945713000133 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 945713000134 putative substrate binding site [chemical binding]; other site 945713000135 putative ATP binding site [chemical binding]; other site 945713000136 RNA polymerase sigma factor; Provisional; Region: PRK12534 945713000137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713000138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713000139 DNA binding residues [nucleotide binding] 945713000140 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 945713000141 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 945713000142 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 945713000143 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 945713000144 motif 1; other site 945713000145 active site 945713000146 motif 2; other site 945713000147 motif 3; other site 945713000148 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 945713000149 DNA repair protein RadA; Provisional; Region: PRK11823 945713000150 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 945713000151 Walker A motif/ATP binding site; other site 945713000152 ATP binding site [chemical binding]; other site 945713000153 Walker B motif; other site 945713000154 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 945713000155 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 945713000156 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 945713000157 ligand binding site [chemical binding]; other site 945713000158 SdpI/YhfL protein family; Region: SdpI; pfam13630 945713000159 DoxX; Region: DoxX; pfam07681 945713000160 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 945713000161 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 945713000162 TAP-like protein; Region: Abhydrolase_4; pfam08386 945713000163 glycogen synthase; Provisional; Region: glgA; PRK00654 945713000164 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 945713000165 ADP-binding pocket [chemical binding]; other site 945713000166 homodimer interface [polypeptide binding]; other site 945713000167 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 945713000168 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 945713000169 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 945713000170 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 945713000171 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 945713000172 isocitrate dehydrogenase; Validated; Region: PRK09222 945713000173 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 945713000174 Ion transport protein; Region: Ion_trans; pfam00520 945713000175 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 945713000176 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 945713000177 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 945713000178 dimer interface [polypeptide binding]; other site 945713000179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713000180 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 945713000181 dimer interface [polypeptide binding]; other site 945713000182 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 945713000183 putative hydrophobic ligand binding site [chemical binding]; other site 945713000184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 945713000185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 945713000186 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 945713000187 dimerization interface [polypeptide binding]; other site 945713000188 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 945713000189 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 945713000190 dimer interface [polypeptide binding]; other site 945713000191 active site 945713000192 heme binding site [chemical binding]; other site 945713000193 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 945713000194 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 945713000195 short chain dehydrogenase; Provisional; Region: PRK06197 945713000196 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 945713000197 putative NAD(P) binding site [chemical binding]; other site 945713000198 active site 945713000199 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 945713000200 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 945713000201 NAD binding site [chemical binding]; other site 945713000202 dimer interface [polypeptide binding]; other site 945713000203 substrate binding site [chemical binding]; other site 945713000204 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945713000205 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 945713000206 tetramerization interface [polypeptide binding]; other site 945713000207 active site 945713000208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713000209 nucleotide binding site [chemical binding]; other site 945713000210 Type III pantothenate kinase; Region: Pan_kinase; cl17198 945713000211 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 945713000212 Flavoprotein; Region: Flavoprotein; pfam02441 945713000213 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 945713000214 pantoate--beta-alanine ligase; Region: panC; TIGR00018 945713000215 Pantoate-beta-alanine ligase; Region: PanC; cd00560 945713000216 active site 945713000217 ATP-binding site [chemical binding]; other site 945713000218 pantoate-binding site; other site 945713000219 HXXH motif; other site 945713000220 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 945713000221 oligomerization interface [polypeptide binding]; other site 945713000222 active site 945713000223 metal binding site [ion binding]; metal-binding site 945713000224 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 945713000225 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 945713000226 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 945713000227 putative NAD(P) binding site [chemical binding]; other site 945713000228 putative active site [active] 945713000229 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 945713000230 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 945713000231 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 945713000232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 945713000233 active site 945713000234 DNA binding site [nucleotide binding] 945713000235 Int/Topo IB signature motif; other site 945713000236 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945713000237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713000238 ATP binding site [chemical binding]; other site 945713000239 putative Mg++ binding site [ion binding]; other site 945713000240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713000241 nucleotide binding region [chemical binding]; other site 945713000242 ATP-binding site [chemical binding]; other site 945713000243 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 945713000244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713000245 active site 945713000246 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 945713000247 DNA protecting protein DprA; Region: dprA; TIGR00732 945713000248 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 945713000249 tape measure domain; Region: tape_meas_nterm; TIGR02675 945713000250 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 945713000251 catalytic residues [active] 945713000252 Gp37 protein; Region: Gp37; pfam09646 945713000253 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 945713000254 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 945713000255 Terminase-like family; Region: Terminase_6; pfam03237 945713000256 Protein of unknown function (DUF935); Region: DUF935; pfam06074 945713000257 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 945713000258 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 945713000259 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 945713000260 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 945713000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000262 Walker A motif; other site 945713000263 ATP binding site [chemical binding]; other site 945713000264 Walker B motif; other site 945713000265 arginine finger; other site 945713000266 Integrase core domain; Region: rve; pfam00665 945713000267 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 945713000268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 945713000269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 945713000270 non-specific DNA binding site [nucleotide binding]; other site 945713000271 salt bridge; other site 945713000272 sequence-specific DNA binding site [nucleotide binding]; other site 945713000273 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 945713000274 RibD C-terminal domain; Region: RibD_C; cl17279 945713000275 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 945713000276 Helix-turn-helix domain; Region: HTH_18; pfam12833 945713000277 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 945713000278 putative dimer interface [polypeptide binding]; other site 945713000279 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713000280 TfoX C-terminal domain; Region: TfoX_C; pfam04994 945713000281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713000282 dimerization interface [polypeptide binding]; other site 945713000283 putative DNA binding site [nucleotide binding]; other site 945713000284 putative Zn2+ binding site [ion binding]; other site 945713000285 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 945713000286 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 945713000287 putative hydrophobic ligand binding site [chemical binding]; other site 945713000288 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 945713000289 dimer interface [polypeptide binding]; other site 945713000290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713000291 DoxX-like family; Region: DoxX_2; pfam13564 945713000292 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 945713000293 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 945713000294 classical (c) SDRs; Region: SDR_c; cd05233 945713000295 NAD(P) binding site [chemical binding]; other site 945713000296 active site 945713000297 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 945713000298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713000299 Coenzyme A binding pocket [chemical binding]; other site 945713000300 Transposase domain (DUF772); Region: DUF772; pfam05598 945713000301 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713000302 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713000303 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713000304 Histidine kinase; Region: His_kinase; pfam06580 945713000305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000306 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 945713000307 active site 945713000308 phosphorylation site [posttranslational modification] 945713000309 intermolecular recognition site; other site 945713000310 dimerization interface [polypeptide binding]; other site 945713000311 LytTr DNA-binding domain; Region: LytTR; smart00850 945713000312 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 945713000313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713000314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713000315 NAD(P) binding site [chemical binding]; other site 945713000316 active site 945713000317 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 945713000318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713000319 Radical SAM superfamily; Region: Radical_SAM; pfam04055 945713000320 FeS/SAM binding site; other site 945713000321 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 945713000322 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 945713000323 Right handed beta helix region; Region: Beta_helix; pfam13229 945713000324 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 945713000325 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000326 ATP cone domain; Region: ATP-cone; pfam03477 945713000327 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 945713000328 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 945713000329 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 945713000330 Walker A/P-loop; other site 945713000331 ATP binding site [chemical binding]; other site 945713000332 Q-loop/lid; other site 945713000333 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 945713000334 ABC transporter signature motif; other site 945713000335 Walker B; other site 945713000336 D-loop; other site 945713000337 H-loop/switch region; other site 945713000338 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 945713000339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713000340 FeS/SAM binding site; other site 945713000341 HemN C-terminal domain; Region: HemN_C; pfam06969 945713000342 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 945713000343 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 945713000344 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 945713000345 active site 945713000346 catalytic triad [active] 945713000347 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713000348 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000349 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945713000350 active site 945713000351 catalytic residues [active] 945713000352 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000353 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 945713000354 Peptidase family M28; Region: Peptidase_M28; pfam04389 945713000355 metal binding site [ion binding]; metal-binding site 945713000356 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 945713000357 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000358 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 945713000359 TPR repeat; Region: TPR_11; pfam13414 945713000360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713000361 binding surface 945713000362 TPR motif; other site 945713000363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713000364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000365 active site 945713000366 phosphorylation site [posttranslational modification] 945713000367 intermolecular recognition site; other site 945713000368 dimerization interface [polypeptide binding]; other site 945713000369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945713000370 DNA binding site [nucleotide binding] 945713000371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713000372 HAMP domain; Region: HAMP; pfam00672 945713000373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000374 dimer interface [polypeptide binding]; other site 945713000375 phosphorylation site [posttranslational modification] 945713000376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000377 ATP binding site [chemical binding]; other site 945713000378 Mg2+ binding site [ion binding]; other site 945713000379 G-X-G motif; other site 945713000380 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 945713000381 homodimer interface [polypeptide binding]; other site 945713000382 substrate-cofactor binding pocket; other site 945713000383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713000384 catalytic residue [active] 945713000385 Uncharacterized conserved protein [Function unknown]; Region: COG4198 945713000386 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 945713000387 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 945713000388 Putative esterase; Region: Esterase; pfam00756 945713000389 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 945713000390 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 945713000391 putative active site [active] 945713000392 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945713000393 active site 945713000394 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 945713000395 ADP-ribose binding site [chemical binding]; other site 945713000396 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 945713000397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945713000398 active site 945713000399 HIGH motif; other site 945713000400 nucleotide binding site [chemical binding]; other site 945713000401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 945713000402 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 945713000403 active site 945713000404 KMSKS motif; other site 945713000405 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 945713000406 tRNA binding surface [nucleotide binding]; other site 945713000407 anticodon binding site; other site 945713000408 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 945713000409 DinB family; Region: DinB; cl17821 945713000410 DinB superfamily; Region: DinB_2; pfam12867 945713000411 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 945713000412 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 945713000413 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 945713000414 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 945713000415 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 945713000416 HEAT repeats; Region: HEAT_2; pfam13646 945713000417 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 945713000418 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 945713000419 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 945713000420 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945713000421 Soluble P-type ATPase [General function prediction only]; Region: COG4087 945713000422 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 945713000423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713000424 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 945713000425 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 945713000426 putative active site [active] 945713000427 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 945713000428 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945713000429 E3 interaction surface; other site 945713000430 lipoyl attachment site [posttranslational modification]; other site 945713000431 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713000432 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 945713000433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713000434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000435 dimer interface [polypeptide binding]; other site 945713000436 phosphorylation site [posttranslational modification] 945713000437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713000438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000439 active site 945713000440 phosphorylation site [posttranslational modification] 945713000441 intermolecular recognition site; other site 945713000442 dimerization interface [polypeptide binding]; other site 945713000443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945713000444 DNA binding site [nucleotide binding] 945713000445 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 945713000446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 945713000447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945713000448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 945713000449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713000450 motif II; other site 945713000451 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 945713000452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 945713000453 active site 945713000454 phosphorylation site [posttranslational modification] 945713000455 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 945713000456 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945713000457 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713000458 active site 945713000459 catalytic site [active] 945713000460 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000461 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000462 MgpC protein precursor; Region: MgpC; pfam05220 945713000463 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 945713000464 Transposase domain (DUF772); Region: DUF772; pfam05598 945713000465 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713000466 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713000467 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713000468 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 945713000469 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 945713000470 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 945713000471 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000472 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 945713000473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713000474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000475 active site 945713000476 phosphorylation site [posttranslational modification] 945713000477 intermolecular recognition site; other site 945713000478 dimerization interface [polypeptide binding]; other site 945713000479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945713000480 DNA binding site [nucleotide binding] 945713000481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713000482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000483 dimer interface [polypeptide binding]; other site 945713000484 phosphorylation site [posttranslational modification] 945713000485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000486 ATP binding site [chemical binding]; other site 945713000487 Mg2+ binding site [ion binding]; other site 945713000488 G-X-G motif; other site 945713000489 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 945713000490 B12 binding domain; Region: B12-binding; pfam02310 945713000491 B12 binding site [chemical binding]; other site 945713000492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713000493 FeS/SAM binding site; other site 945713000494 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 945713000495 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 945713000496 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713000497 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 945713000498 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713000499 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 945713000500 putative active site [active] 945713000501 YdjC motif; other site 945713000502 Mg binding site [ion binding]; other site 945713000503 homodimer interface [polypeptide binding]; other site 945713000504 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 945713000505 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 945713000506 TPP-binding site [chemical binding]; other site 945713000507 dimer interface [polypeptide binding]; other site 945713000508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945713000509 PYR/PP interface [polypeptide binding]; other site 945713000510 dimer interface [polypeptide binding]; other site 945713000511 TPP binding site [chemical binding]; other site 945713000512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713000513 Haem-binding domain; Region: Haem_bd; pfam14376 945713000514 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 945713000515 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 945713000516 phosphodiesterase; Provisional; Region: PRK12704 945713000517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 945713000518 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 945713000519 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 945713000520 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 945713000521 putative ligand binding pocket/active site [active] 945713000522 putative metal binding site [ion binding]; other site 945713000523 methionine sulfoxide reductase A; Provisional; Region: PRK14054 945713000524 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 945713000525 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 945713000526 putative active site [active] 945713000527 oxyanion strand; other site 945713000528 catalytic triad [active] 945713000529 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945713000530 active site 945713000531 RNA polymerase sigma factor; Provisional; Region: PRK12519 945713000532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713000533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713000534 DNA binding residues [nucleotide binding] 945713000535 Arginase family; Region: Arginase; cd09989 945713000536 agmatinase; Region: agmatinase; TIGR01230 945713000537 active site 945713000538 Mn binding site [ion binding]; other site 945713000539 oligomer interface [polypeptide binding]; other site 945713000540 Stage II sporulation protein; Region: SpoIID; pfam08486 945713000541 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 945713000542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713000543 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945713000544 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 945713000545 nucleotide binding site/active site [active] 945713000546 HIT family signature motif; other site 945713000547 catalytic residue [active] 945713000548 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 945713000549 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000550 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 945713000551 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713000552 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713000553 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 945713000554 galactinol-raffinose galactosyltransferase/ghydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02982 945713000555 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 945713000556 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 945713000557 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 945713000558 Putative esterase; Region: Esterase; pfam00756 945713000559 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000560 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 945713000561 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 945713000562 MOSC domain; Region: MOSC; pfam03473 945713000563 Domain of unknown function (DUF389); Region: DUF389; pfam04087 945713000564 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 945713000565 Uncharacterized conserved protein [Function unknown]; Region: COG1656 945713000566 Protein of unknown function DUF82; Region: DUF82; pfam01927 945713000567 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713000568 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713000569 putative active site [active] 945713000570 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 945713000571 dimer interface [polypeptide binding]; other site 945713000572 active site 945713000573 Schiff base residues; other site 945713000574 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713000575 four helix bundle protein; Region: TIGR02436 945713000576 protoporphyrinogen oxidase; Region: PLN02576 945713000577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713000578 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 945713000579 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713000580 4-alpha-glucanotransferase; Provisional; Region: PRK14508 945713000581 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713000582 Predicted membrane protein [Function unknown]; Region: COG1238 945713000583 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 945713000584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713000585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000586 PAS domain; Region: PAS_9; pfam13426 945713000587 putative active site [active] 945713000588 heme pocket [chemical binding]; other site 945713000589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000590 PAS domain; Region: PAS_9; pfam13426 945713000591 putative active site [active] 945713000592 heme pocket [chemical binding]; other site 945713000593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000594 PAS fold; Region: PAS_3; pfam08447 945713000595 putative active site [active] 945713000596 heme pocket [chemical binding]; other site 945713000597 PAS domain S-box; Region: sensory_box; TIGR00229 945713000598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000599 putative active site [active] 945713000600 heme pocket [chemical binding]; other site 945713000601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000602 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713000603 putative active site [active] 945713000604 heme pocket [chemical binding]; other site 945713000605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000606 putative active site [active] 945713000607 heme pocket [chemical binding]; other site 945713000608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000609 PAS fold; Region: PAS_3; pfam08447 945713000610 putative active site [active] 945713000611 heme pocket [chemical binding]; other site 945713000612 GAF domain; Region: GAF_2; pfam13185 945713000613 GAF domain; Region: GAF; pfam01590 945713000614 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 945713000615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000616 putative active site [active] 945713000617 heme pocket [chemical binding]; other site 945713000618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000619 putative active site [active] 945713000620 heme pocket [chemical binding]; other site 945713000621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000622 dimer interface [polypeptide binding]; other site 945713000623 phosphorylation site [posttranslational modification] 945713000624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000625 ATP binding site [chemical binding]; other site 945713000626 G-X-G motif; other site 945713000627 Response regulator receiver domain; Region: Response_reg; pfam00072 945713000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000629 active site 945713000630 phosphorylation site [posttranslational modification] 945713000631 intermolecular recognition site; other site 945713000632 dimerization interface [polypeptide binding]; other site 945713000633 GYD domain; Region: GYD; cl01743 945713000634 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 945713000635 putative deacylase active site [active] 945713000636 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 945713000637 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 945713000638 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713000639 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713000640 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713000641 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713000642 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713000643 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713000644 AAA domain; Region: AAA_14; pfam13173 945713000645 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 945713000646 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 945713000647 ferredoxin; Validated; Region: PRK07118 945713000648 4Fe-4S binding domain; Region: Fer4; pfam00037 945713000649 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 945713000650 ApbE family; Region: ApbE; pfam02424 945713000651 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 945713000652 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206 945713000653 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 945713000654 electron transport complex RsxE subunit; Provisional; Region: PRK12405 945713000655 FMN-binding domain; Region: FMN_bind; pfam04205 945713000656 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 945713000657 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 945713000658 SLBB domain; Region: SLBB; pfam10531 945713000659 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713000662 active site 945713000663 phosphorylation site [posttranslational modification] 945713000664 intermolecular recognition site; other site 945713000665 dimerization interface [polypeptide binding]; other site 945713000666 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 945713000667 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 945713000668 putative dimer interface [polypeptide binding]; other site 945713000669 [2Fe-2S] cluster binding site [ion binding]; other site 945713000670 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 945713000671 SLBB domain; Region: SLBB; pfam10531 945713000672 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 945713000673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 945713000674 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 945713000675 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 945713000676 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 945713000677 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 945713000678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713000679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000680 dimer interface [polypeptide binding]; other site 945713000681 phosphorylation site [posttranslational modification] 945713000682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000683 ATP binding site [chemical binding]; other site 945713000684 Mg2+ binding site [ion binding]; other site 945713000685 G-X-G motif; other site 945713000686 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000688 active site 945713000689 phosphorylation site [posttranslational modification] 945713000690 intermolecular recognition site; other site 945713000691 dimerization interface [polypeptide binding]; other site 945713000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000693 Walker A motif; other site 945713000694 ATP binding site [chemical binding]; other site 945713000695 Walker B motif; other site 945713000696 arginine finger; other site 945713000697 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713000698 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 945713000699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000700 putative active site [active] 945713000701 heme pocket [chemical binding]; other site 945713000702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000703 dimer interface [polypeptide binding]; other site 945713000704 phosphorylation site [posttranslational modification] 945713000705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000706 ATP binding site [chemical binding]; other site 945713000707 Mg2+ binding site [ion binding]; other site 945713000708 G-X-G motif; other site 945713000709 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 945713000710 diiron binding motif [ion binding]; other site 945713000711 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 945713000712 sphingolipid delta-4 desaturase; Region: PLN02579 945713000713 Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557 945713000714 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 945713000715 putative di-iron ligands [ion binding]; other site 945713000716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945713000717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945713000718 active site 945713000719 catalytic tetrad [active] 945713000720 Ferredoxin [Energy production and conversion]; Region: COG1146 945713000721 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 945713000722 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 945713000723 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 945713000724 dimer interface [polypeptide binding]; other site 945713000725 PYR/PP interface [polypeptide binding]; other site 945713000726 TPP binding site [chemical binding]; other site 945713000727 substrate binding site [chemical binding]; other site 945713000728 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713000729 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 945713000730 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 945713000731 TPP-binding site [chemical binding]; other site 945713000732 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 945713000733 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 945713000734 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 945713000735 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713000736 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713000737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713000738 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713000739 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713000740 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713000741 Helix-turn-helix domain; Region: HTH_17; pfam12728 945713000742 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 945713000743 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 945713000744 short chain dehydrogenase; Provisional; Region: PRK06197 945713000745 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 945713000746 putative NAD(P) binding site [chemical binding]; other site 945713000747 active site 945713000748 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713000749 DNA polymerase III subunit beta; Provisional; Region: PRK14943 945713000750 CHASE2 domain; Region: CHASE2; pfam05226 945713000751 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000753 Walker A motif; other site 945713000754 ATP binding site [chemical binding]; other site 945713000755 Walker B motif; other site 945713000756 arginine finger; other site 945713000757 glutamate racemase; Provisional; Region: PRK00865 945713000758 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945713000759 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 945713000760 metal binding triad; other site 945713000761 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 945713000762 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 945713000763 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 945713000764 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 945713000765 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 945713000766 Ligand Binding Site [chemical binding]; other site 945713000767 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 945713000768 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 945713000769 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 945713000770 active site 945713000771 metal binding site [ion binding]; metal-binding site 945713000772 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 945713000773 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 945713000774 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000775 Repair protein; Region: Repair_PSII; pfam04536 945713000776 Uncharacterized conserved protein [Function unknown]; Region: COG3595 945713000777 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 945713000778 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 945713000779 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 945713000780 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 945713000781 TrkA-N domain; Region: TrkA_N; pfam02254 945713000782 TrkA-C domain; Region: TrkA_C; pfam02080 945713000783 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 945713000784 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 945713000785 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 945713000786 NAD(P) binding site [chemical binding]; other site 945713000787 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 945713000788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 945713000789 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713000790 phosphorylation site [posttranslational modification] 945713000791 intermolecular recognition site; other site 945713000792 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 945713000793 glutamate dehydrogenase; Provisional; Region: PRK09414 945713000794 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 945713000795 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 945713000796 NAD(P) binding site [chemical binding]; other site 945713000797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000799 active site 945713000800 phosphorylation site [posttranslational modification] 945713000801 intermolecular recognition site; other site 945713000802 dimerization interface [polypeptide binding]; other site 945713000803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713000804 DNA binding residues [nucleotide binding] 945713000805 dimerization interface [polypeptide binding]; other site 945713000806 PAS domain S-box; Region: sensory_box; TIGR00229 945713000807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000808 putative active site [active] 945713000809 heme pocket [chemical binding]; other site 945713000810 PAS domain S-box; Region: sensory_box; TIGR00229 945713000811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713000812 putative active site [active] 945713000813 heme pocket [chemical binding]; other site 945713000814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945713000815 Histidine kinase; Region: HisKA_3; pfam07730 945713000816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000817 ATP binding site [chemical binding]; other site 945713000818 Mg2+ binding site [ion binding]; other site 945713000819 G-X-G motif; other site 945713000820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000821 phosphorylation site [posttranslational modification] 945713000822 intermolecular recognition site; other site 945713000823 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 945713000824 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 945713000825 IHF dimer interface [polypeptide binding]; other site 945713000826 IHF - DNA interface [nucleotide binding]; other site 945713000827 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713000828 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 945713000829 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 945713000830 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 945713000831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000832 active site 945713000833 phosphorylation site [posttranslational modification] 945713000834 intermolecular recognition site; other site 945713000835 dimerization interface [polypeptide binding]; other site 945713000836 LytTr DNA-binding domain; Region: LytTR; smart00850 945713000837 Histidine kinase; Region: His_kinase; pfam06580 945713000838 RIP metalloprotease RseP; Region: TIGR00054 945713000839 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 945713000840 active site 945713000841 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 945713000842 protein binding site [polypeptide binding]; other site 945713000843 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 945713000844 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 945713000845 putative substrate binding region [chemical binding]; other site 945713000846 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 945713000847 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 945713000848 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 945713000849 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 945713000850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713000851 binding surface 945713000852 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713000853 TPR motif; other site 945713000854 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 945713000855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713000856 binding surface 945713000857 TPR motif; other site 945713000858 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 945713000859 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 945713000860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713000861 Walker A motif; other site 945713000862 ATP binding site [chemical binding]; other site 945713000863 Walker B motif; other site 945713000864 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 945713000865 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 945713000866 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 945713000867 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 945713000868 RuvA N terminal domain; Region: RuvA_N; pfam01330 945713000869 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 945713000870 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 945713000871 active site 945713000872 putative DNA-binding cleft [nucleotide binding]; other site 945713000873 dimer interface [polypeptide binding]; other site 945713000874 hypothetical protein; Validated; Region: PRK00110 945713000875 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 945713000876 DHH family; Region: DHH; pfam01368 945713000877 DHHA1 domain; Region: DHHA1; pfam02272 945713000878 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 945713000879 Putative zinc ribbon domain; Region: DUF164; pfam02591 945713000880 Uncharacterized conserved protein [Function unknown]; Region: COG0327 945713000881 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 945713000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 945713000883 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 945713000884 Uncharacterized conserved protein [Function unknown]; Region: COG0327 945713000885 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 945713000886 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 945713000887 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 945713000888 DNA primase; Validated; Region: dnaG; PRK05667 945713000889 CHC2 zinc finger; Region: zf-CHC2; pfam01807 945713000890 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 945713000891 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 945713000892 active site 945713000893 metal binding site [ion binding]; metal-binding site 945713000894 interdomain interaction site; other site 945713000895 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 945713000896 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 945713000897 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 945713000898 four helix bundle protein; Region: TIGR02436 945713000899 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 945713000900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713000901 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 945713000902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 945713000903 non-specific DNA binding site [nucleotide binding]; other site 945713000904 salt bridge; other site 945713000905 sequence-specific DNA binding site [nucleotide binding]; other site 945713000906 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713000907 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713000908 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713000909 PAS fold; Region: PAS_3; pfam08447 945713000910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713000911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713000912 dimer interface [polypeptide binding]; other site 945713000913 phosphorylation site [posttranslational modification] 945713000914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713000915 ATP binding site [chemical binding]; other site 945713000916 Mg2+ binding site [ion binding]; other site 945713000917 G-X-G motif; other site 945713000918 Response regulator receiver domain; Region: Response_reg; pfam00072 945713000919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713000920 active site 945713000921 phosphorylation site [posttranslational modification] 945713000922 intermolecular recognition site; other site 945713000923 dimerization interface [polypeptide binding]; other site 945713000924 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 945713000925 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 945713000926 generic binding surface II; other site 945713000927 generic binding surface I; other site 945713000928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713000929 Zn2+ binding site [ion binding]; other site 945713000930 Mg2+ binding site [ion binding]; other site 945713000931 TPR repeat; Region: TPR_11; pfam13414 945713000932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713000933 binding surface 945713000934 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 945713000935 NAD-dependent deacetylase; Provisional; Region: PRK00481 945713000936 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 945713000937 NAD+ binding site [chemical binding]; other site 945713000938 substrate binding site [chemical binding]; other site 945713000939 Zn binding site [ion binding]; other site 945713000940 Family description; Region: VCBS; pfam13517 945713000941 Family description; Region: VCBS; pfam13517 945713000942 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000943 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 945713000944 substrate binding site; other site 945713000945 dimer interface; other site 945713000946 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 945713000947 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 945713000948 pyruvate phosphate dikinase; Provisional; Region: PRK09279 945713000949 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 945713000950 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 945713000951 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 945713000952 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 945713000953 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 945713000954 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945713000955 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 945713000956 putative acyl-acceptor binding pocket; other site 945713000957 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 945713000958 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 945713000959 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 945713000960 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 945713000961 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 945713000962 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713000963 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 945713000964 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 945713000965 Walker A/P-loop; other site 945713000966 ATP binding site [chemical binding]; other site 945713000967 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 945713000968 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 945713000969 ABC transporter signature motif; other site 945713000970 Walker B; other site 945713000971 D-loop; other site 945713000972 H-loop/switch region; other site 945713000973 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 945713000974 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 945713000975 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 945713000976 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 945713000977 excinuclease ABC subunit B; Provisional; Region: PRK05298 945713000978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713000979 ATP binding site [chemical binding]; other site 945713000980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713000981 nucleotide binding region [chemical binding]; other site 945713000982 ATP-binding site [chemical binding]; other site 945713000983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 945713000984 UvrB/uvrC motif; Region: UVR; pfam02151 945713000985 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 945713000986 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 945713000987 dimerization interface 3.5A [polypeptide binding]; other site 945713000988 active site 945713000989 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 945713000990 active site 945713000991 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 945713000992 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 945713000993 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 945713000994 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 945713000995 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 945713000996 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 945713000997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713000998 active site 945713000999 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945713001000 putative trimer interface [polypeptide binding]; other site 945713001001 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945713001002 putative CoA binding site [chemical binding]; other site 945713001003 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 945713001004 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 945713001005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945713001006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945713001007 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 945713001008 Walker A/P-loop; other site 945713001009 ATP binding site [chemical binding]; other site 945713001010 Q-loop/lid; other site 945713001011 ABC transporter signature motif; other site 945713001012 Walker B; other site 945713001013 D-loop; other site 945713001014 H-loop/switch region; other site 945713001015 Peptidase family M50; Region: Peptidase_M50; pfam02163 945713001016 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 945713001017 active site 945713001018 putative substrate binding region [chemical binding]; other site 945713001019 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 945713001020 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 945713001021 active site 945713001022 Int/Topo IB signature motif; other site 945713001023 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 945713001024 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 945713001025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713001026 Zn2+ binding site [ion binding]; other site 945713001027 Mg2+ binding site [ion binding]; other site 945713001028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713001029 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 945713001030 active site 945713001031 motif I; other site 945713001032 motif II; other site 945713001033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713001034 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 945713001035 Family description; Region: VCBS; pfam13517 945713001036 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713001037 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001038 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713001039 anti sigma factor interaction site; other site 945713001040 regulatory phosphorylation site [posttranslational modification]; other site 945713001041 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 945713001042 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 945713001043 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 945713001044 nucleotide binding pocket [chemical binding]; other site 945713001045 K-X-D-G motif; other site 945713001046 catalytic site [active] 945713001047 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 945713001048 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 945713001049 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 945713001050 Dimer interface [polypeptide binding]; other site 945713001051 BRCT sequence motif; other site 945713001052 Helix-turn-helix domain; Region: HTH_25; pfam13413 945713001053 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 945713001054 16S rRNA methyltransferase B; Provisional; Region: PRK14902 945713001055 NusB family; Region: NusB; pfam01029 945713001056 putative RNA binding site [nucleotide binding]; other site 945713001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713001058 S-adenosylmethionine binding site [chemical binding]; other site 945713001059 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 945713001060 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 945713001061 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 945713001062 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 945713001063 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 945713001064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713001065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713001066 DNA binding residues [nucleotide binding] 945713001067 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 945713001068 putative deacylase active site [active] 945713001069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 945713001070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945713001071 Walker A/P-loop; other site 945713001072 ATP binding site [chemical binding]; other site 945713001073 Q-loop/lid; other site 945713001074 ABC transporter signature motif; other site 945713001075 Walker B; other site 945713001076 D-loop; other site 945713001077 H-loop/switch region; other site 945713001078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 945713001079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 945713001080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713001081 Walker A/P-loop; other site 945713001082 ATP binding site [chemical binding]; other site 945713001083 Q-loop/lid; other site 945713001084 ABC transporter signature motif; other site 945713001085 Walker B; other site 945713001086 D-loop; other site 945713001087 H-loop/switch region; other site 945713001088 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 945713001089 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 945713001090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 945713001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713001092 dimer interface [polypeptide binding]; other site 945713001093 conserved gate region; other site 945713001094 putative PBP binding loops; other site 945713001095 ABC-ATPase subunit interface; other site 945713001096 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 945713001097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713001098 dimer interface [polypeptide binding]; other site 945713001099 conserved gate region; other site 945713001100 putative PBP binding loops; other site 945713001101 ABC-ATPase subunit interface; other site 945713001102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945713001103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 945713001104 active site 945713001105 ATP binding site [chemical binding]; other site 945713001106 substrate binding site [chemical binding]; other site 945713001107 activation loop (A-loop); other site 945713001108 Archaeal ATPase; Region: Arch_ATPase; pfam01637 945713001109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713001110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713001111 binding surface 945713001112 TPR motif; other site 945713001113 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 945713001114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713001115 Walker A motif; other site 945713001116 ATP binding site [chemical binding]; other site 945713001117 Walker B motif; other site 945713001118 arginine finger; other site 945713001119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713001120 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 945713001121 GAF domain; Region: GAF_3; pfam13492 945713001122 GAF domain; Region: GAF_2; pfam13185 945713001123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713001124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001125 ATP binding site [chemical binding]; other site 945713001126 Mg2+ binding site [ion binding]; other site 945713001127 G-X-G motif; other site 945713001128 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713001129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001130 putative active site [active] 945713001131 heme pocket [chemical binding]; other site 945713001132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001133 dimer interface [polypeptide binding]; other site 945713001134 phosphorylation site [posttranslational modification] 945713001135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001136 ATP binding site [chemical binding]; other site 945713001137 Mg2+ binding site [ion binding]; other site 945713001138 G-X-G motif; other site 945713001139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001140 active site 945713001141 dimerization interface [polypeptide binding]; other site 945713001142 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 945713001143 Fatty acid desaturase; Region: FA_desaturase; pfam00487 945713001144 putative di-iron ligands [ion binding]; other site 945713001145 Protein of unknown function (DUF422); Region: DUF422; cl00991 945713001146 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 945713001147 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 945713001148 DXD motif; other site 945713001149 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 945713001150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945713001151 putative acyl-acceptor binding pocket; other site 945713001152 phytoene desaturase; Region: crtI_fam; TIGR02734 945713001153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713001154 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 945713001155 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 945713001156 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 945713001157 active site lid residues [active] 945713001158 substrate binding pocket [chemical binding]; other site 945713001159 catalytic residues [active] 945713001160 substrate-Mg2+ binding site; other site 945713001161 aspartate-rich region 1; other site 945713001162 aspartate-rich region 2; other site 945713001163 phytoene desaturase; Region: crtI_fam; TIGR02734 945713001164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713001165 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 945713001166 nudix motif; other site 945713001167 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 945713001168 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945713001169 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 945713001170 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 945713001171 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 945713001172 A new structural DNA glycosylase; Region: AlkD_like; cd06561 945713001173 active site 945713001174 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 945713001175 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 945713001176 putative NAD(P) binding site [chemical binding]; other site 945713001177 putative active site [active] 945713001178 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 945713001179 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 945713001180 homotetramer interface [polypeptide binding]; other site 945713001181 ligand binding site [chemical binding]; other site 945713001182 catalytic site [active] 945713001183 NAD binding site [chemical binding]; other site 945713001184 S-adenosylmethionine synthetase; Validated; Region: PRK05250 945713001185 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 945713001186 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 945713001187 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 945713001188 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 945713001189 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 945713001190 FMN binding site [chemical binding]; other site 945713001191 substrate binding site [chemical binding]; other site 945713001192 putative catalytic residue [active] 945713001193 LytB protein; Region: LYTB; cl00507 945713001194 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 945713001195 peptide chain release factor 1; Validated; Region: prfA; PRK00591 945713001196 This domain is found in peptide chain release factors; Region: PCRF; smart00937 945713001197 RF-1 domain; Region: RF-1; pfam00472 945713001198 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713001199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001200 active site 945713001201 phosphorylation site [posttranslational modification] 945713001202 intermolecular recognition site; other site 945713001203 dimerization interface [polypeptide binding]; other site 945713001204 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001206 active site 945713001207 phosphorylation site [posttranslational modification] 945713001208 intermolecular recognition site; other site 945713001209 dimerization interface [polypeptide binding]; other site 945713001210 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713001211 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713001212 anti sigma factor interaction site; other site 945713001213 regulatory phosphorylation site [posttranslational modification]; other site 945713001214 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713001215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001216 active site 945713001217 phosphorylation site [posttranslational modification] 945713001218 intermolecular recognition site; other site 945713001219 dimerization interface [polypeptide binding]; other site 945713001220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713001221 Walker A motif; other site 945713001222 ATP binding site [chemical binding]; other site 945713001223 Walker B motif; other site 945713001224 arginine finger; other site 945713001225 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713001226 PAS domain; Region: PAS; smart00091 945713001227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713001228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001229 dimer interface [polypeptide binding]; other site 945713001230 phosphorylation site [posttranslational modification] 945713001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001232 ATP binding site [chemical binding]; other site 945713001233 Mg2+ binding site [ion binding]; other site 945713001234 G-X-G motif; other site 945713001235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713001236 ABC-ATPase subunit interface; other site 945713001237 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 945713001238 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 945713001239 linker region; other site 945713001240 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 945713001241 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 945713001242 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 945713001243 Catalytic site; other site 945713001244 gliding motility-associated protein GldC; Region: GldC; TIGR03515 945713001245 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 945713001246 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 945713001247 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 945713001248 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 945713001249 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 945713001250 Putative amidase domain; Region: Amidase_6; pfam12671 945713001251 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001252 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 945713001253 pseudouridine synthase; Region: TIGR00093 945713001254 probable active site [active] 945713001255 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 945713001256 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 945713001257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 945713001258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713001259 catalytic residue [active] 945713001260 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 945713001261 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 945713001262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 945713001263 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 945713001264 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 945713001265 nucleophilic elbow; other site 945713001266 catalytic triad; other site 945713001267 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 945713001268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945713001269 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 945713001270 acyl-activating enzyme (AAE) consensus motif; other site 945713001271 acyl-activating enzyme (AAE) consensus motif; other site 945713001272 putative AMP binding site [chemical binding]; other site 945713001273 putative active site [active] 945713001274 putative CoA binding site [chemical binding]; other site 945713001275 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 945713001276 Na binding site [ion binding]; other site 945713001277 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 945713001278 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 945713001279 dimer interface [polypeptide binding]; other site 945713001280 active site 945713001281 CoA binding pocket [chemical binding]; other site 945713001282 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 945713001283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713001284 NAD(P) binding site [chemical binding]; other site 945713001285 active site 945713001286 Predicted transcriptional regulators [Transcription]; Region: COG1510 945713001287 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 945713001288 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 945713001289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001290 active site 945713001291 phosphorylation site [posttranslational modification] 945713001292 intermolecular recognition site; other site 945713001293 dimerization interface [polypeptide binding]; other site 945713001294 LytTr DNA-binding domain; Region: LytTR; smart00850 945713001295 Histidine kinase; Region: His_kinase; pfam06580 945713001296 Predicted membrane protein [Function unknown]; Region: COG4758 945713001297 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 945713001298 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 945713001299 active site 945713001300 catalytic triad [active] 945713001301 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 945713001302 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 945713001303 homodimer interface [polypeptide binding]; other site 945713001304 substrate-cofactor binding pocket; other site 945713001305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713001306 catalytic residue [active] 945713001307 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 945713001308 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 945713001309 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 945713001310 histidinol dehydrogenase; Region: hisD; TIGR00069 945713001311 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 945713001312 NAD binding site [chemical binding]; other site 945713001313 dimerization interface [polypeptide binding]; other site 945713001314 product binding site; other site 945713001315 substrate binding site [chemical binding]; other site 945713001316 zinc binding site [ion binding]; other site 945713001317 catalytic residues [active] 945713001318 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 945713001319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713001320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713001321 homodimer interface [polypeptide binding]; other site 945713001322 catalytic residue [active] 945713001323 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 945713001324 putative active site pocket [active] 945713001325 4-fold oligomerization interface [polypeptide binding]; other site 945713001326 metal binding residues [ion binding]; metal-binding site 945713001327 3-fold/trimer interface [polypeptide binding]; other site 945713001328 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 945713001329 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 945713001330 putative active site [active] 945713001331 oxyanion strand; other site 945713001332 catalytic triad [active] 945713001333 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 945713001334 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 945713001335 catalytic residues [active] 945713001336 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 945713001337 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 945713001338 substrate binding site [chemical binding]; other site 945713001339 glutamase interaction surface [polypeptide binding]; other site 945713001340 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 945713001341 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 945713001342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 945713001343 metal binding site [ion binding]; metal-binding site 945713001344 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 945713001345 Beta-lactamase; Region: Beta-lactamase; pfam00144 945713001346 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 945713001347 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 945713001348 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 945713001349 putative active site [active] 945713001350 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 945713001351 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 945713001352 active site 945713001353 HIGH motif; other site 945713001354 KMSKS motif; other site 945713001355 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 945713001356 tRNA binding surface [nucleotide binding]; other site 945713001357 anticodon binding site; other site 945713001358 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 945713001359 dimer interface [polypeptide binding]; other site 945713001360 putative tRNA-binding site [nucleotide binding]; other site 945713001361 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 945713001362 active site 945713001363 catalytic triad [active] 945713001364 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001365 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 945713001366 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 945713001367 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 945713001368 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 945713001369 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 945713001370 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 945713001371 SurA N-terminal domain; Region: SurA_N; pfam09312 945713001372 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 945713001373 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 945713001374 MoxR-like ATPases [General function prediction only]; Region: COG0714 945713001375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713001376 Walker A motif; other site 945713001377 ATP binding site [chemical binding]; other site 945713001378 Walker B motif; other site 945713001379 arginine finger; other site 945713001380 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 945713001381 Protein of unknown function DUF72; Region: DUF72; pfam01904 945713001382 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 945713001383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945713001384 catalytic residue [active] 945713001385 DivIVA protein; Region: DivIVA; pfam05103 945713001386 DivIVA domain; Region: DivI1A_domain; TIGR03544 945713001387 purine nucleoside phosphorylase; Provisional; Region: PRK08202 945713001388 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 945713001389 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 945713001390 HIGH motif; other site 945713001391 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 945713001392 active site 945713001393 KMSKS motif; other site 945713001394 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 945713001395 tRNA binding surface [nucleotide binding]; other site 945713001396 anticodon binding site; other site 945713001397 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 945713001398 lipoprotein signal peptidase; Provisional; Region: PRK14787 945713001399 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 945713001400 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 945713001401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945713001402 RNA binding surface [nucleotide binding]; other site 945713001403 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 945713001404 active site 945713001405 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 945713001406 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 945713001407 active site 945713001408 HIGH motif; other site 945713001409 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 945713001410 KMSKS motif; other site 945713001411 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 945713001412 tRNA binding surface [nucleotide binding]; other site 945713001413 anticodon binding site; other site 945713001414 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001415 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 945713001416 FAD binding domain; Region: FAD_binding_4; pfam01565 945713001417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 945713001418 active site 945713001419 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 945713001420 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 945713001421 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713001422 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713001423 ligand binding site [chemical binding]; other site 945713001424 flexible hinge region; other site 945713001425 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 945713001426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713001427 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 945713001428 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 945713001429 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713001430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713001431 DNA binding residues [nucleotide binding] 945713001432 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 945713001433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945713001434 active site residue [active] 945713001435 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713001436 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713001437 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713001438 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 945713001439 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713001440 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 945713001441 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001442 PAS domain; Region: PAS; smart00091 945713001443 PAS domain; Region: PAS_9; pfam13426 945713001444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001445 PAS domain; Region: PAS_9; pfam13426 945713001446 putative active site [active] 945713001447 heme pocket [chemical binding]; other site 945713001448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001449 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713001450 putative active site [active] 945713001451 heme pocket [chemical binding]; other site 945713001452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001453 putative active site [active] 945713001454 heme pocket [chemical binding]; other site 945713001455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 945713001456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001457 dimer interface [polypeptide binding]; other site 945713001458 phosphorylation site [posttranslational modification] 945713001459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001460 ATP binding site [chemical binding]; other site 945713001461 Mg2+ binding site [ion binding]; other site 945713001462 G-X-G motif; other site 945713001463 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001465 active site 945713001466 phosphorylation site [posttranslational modification] 945713001467 intermolecular recognition site; other site 945713001468 dimerization interface [polypeptide binding]; other site 945713001469 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 945713001470 Permease; Region: Permease; pfam02405 945713001471 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 945713001472 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 945713001473 homodimer interface [polypeptide binding]; other site 945713001474 substrate-cofactor binding pocket; other site 945713001475 catalytic residue [active] 945713001476 LexA repressor; Validated; Region: PRK00215 945713001477 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 945713001478 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 945713001479 Catalytic site [active] 945713001480 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 945713001481 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 945713001482 catalytic residue [active] 945713001483 putative FPP diphosphate binding site; other site 945713001484 putative FPP binding hydrophobic cleft; other site 945713001485 dimer interface [polypeptide binding]; other site 945713001486 putative IPP diphosphate binding site; other site 945713001487 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 945713001488 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713001489 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713001490 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713001491 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713001492 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713001493 periplasmic chaperone; Provisional; Region: PRK10780 945713001494 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 945713001495 periplasmic chaperone; Provisional; Region: PRK10780 945713001496 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 945713001497 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 945713001498 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 945713001499 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 945713001500 trimer interface [polypeptide binding]; other site 945713001501 active site 945713001502 UDP-GlcNAc binding site [chemical binding]; other site 945713001503 lipid binding site [chemical binding]; lipid-binding site 945713001504 MarR family; Region: MarR_2; cl17246 945713001505 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945713001506 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 945713001507 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 945713001508 DinB superfamily; Region: DinB_2; pfam12867 945713001509 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 945713001510 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713001511 B12 binding site [chemical binding]; other site 945713001512 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 945713001513 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 945713001514 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 945713001515 FeoA domain; Region: FeoA; pfam04023 945713001516 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 945713001517 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 945713001518 FeoA domain; Region: FeoA; pfam04023 945713001519 FeoA domain; Region: FeoA; pfam04023 945713001520 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 945713001521 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 945713001522 G1 box; other site 945713001523 GTP/Mg2+ binding site [chemical binding]; other site 945713001524 Switch I region; other site 945713001525 G2 box; other site 945713001526 G3 box; other site 945713001527 Switch II region; other site 945713001528 G4 box; other site 945713001529 G5 box; other site 945713001530 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 945713001531 Nucleoside recognition; Region: Gate; pfam07670 945713001532 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 945713001533 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 945713001534 dinuclear metal binding motif [ion binding]; other site 945713001535 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 945713001536 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 945713001537 active site 945713001538 putative catalytic site [active] 945713001539 phosphate binding site A [ion binding]; other site 945713001540 DNA binding site [nucleotide binding] 945713001541 metal binding site A [ion binding]; metal-binding site 945713001542 putative AP binding site [nucleotide binding]; other site 945713001543 putative metal binding site B [ion binding]; other site 945713001544 phosphate binding site B [ion binding]; other site 945713001545 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 945713001546 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 945713001547 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713001548 putative catalytic residue [active] 945713001549 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 945713001550 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 945713001551 photolyase PhrII; Region: phr2; TIGR00591 945713001552 DNA photolyase; Region: DNA_photolyase; pfam00875 945713001553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945713001554 dimerization interface [polypeptide binding]; other site 945713001555 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713001556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001557 putative active site [active] 945713001558 heme pocket [chemical binding]; other site 945713001559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001560 dimer interface [polypeptide binding]; other site 945713001561 phosphorylation site [posttranslational modification] 945713001562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001563 ATP binding site [chemical binding]; other site 945713001564 Mg2+ binding site [ion binding]; other site 945713001565 G-X-G motif; other site 945713001566 isocitrate dehydrogenase; Validated; Region: PRK09222 945713001567 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 945713001568 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 945713001569 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 945713001570 active site residue [active] 945713001571 Methyltransferase domain; Region: Methyltransf_11; pfam08241 945713001572 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 945713001573 active site 945713001574 dinuclear metal binding site [ion binding]; other site 945713001575 dimerization interface [polypeptide binding]; other site 945713001576 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 945713001577 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 945713001578 MG2 domain; Region: A2M_N; pfam01835 945713001579 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 945713001580 Alpha-2-macroglobulin family; Region: A2M; pfam00207 945713001581 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 945713001582 surface patch; other site 945713001583 thioester region; other site 945713001584 A-macroglobulin complement component; Region: A2M_comp; pfam07678 945713001585 biotin synthase; Provisional; Region: PRK07094 945713001586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001587 FeS/SAM binding site; other site 945713001588 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 945713001589 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 945713001590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001591 FeS/SAM binding site; other site 945713001592 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 945713001593 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 945713001594 Aspartase; Region: Aspartase; cd01357 945713001595 active sites [active] 945713001596 tetramer interface [polypeptide binding]; other site 945713001597 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 945713001598 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 945713001599 G1 box; other site 945713001600 GTP/Mg2+ binding site [chemical binding]; other site 945713001601 Switch I region; other site 945713001602 G2 box; other site 945713001603 Switch II region; other site 945713001604 G3 box; other site 945713001605 G4 box; other site 945713001606 G5 box; other site 945713001607 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 945713001608 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 945713001609 putative dimer interface [polypeptide binding]; other site 945713001610 [2Fe-2S] cluster binding site [ion binding]; other site 945713001611 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 945713001612 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 945713001613 SLBB domain; Region: SLBB; pfam10531 945713001614 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 945713001615 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 945713001616 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 945713001617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 945713001618 catalytic loop [active] 945713001619 iron binding site [ion binding]; other site 945713001620 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 945713001621 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 945713001622 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 945713001623 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 945713001624 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 945713001625 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 945713001626 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 945713001627 Putative Fe-S cluster; Region: FeS; cl17515 945713001628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001629 dimer interface [polypeptide binding]; other site 945713001630 phosphorylation site [posttranslational modification] 945713001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001632 ATP binding site [chemical binding]; other site 945713001633 Mg2+ binding site [ion binding]; other site 945713001634 G-X-G motif; other site 945713001635 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713001636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001637 active site 945713001638 phosphorylation site [posttranslational modification] 945713001639 intermolecular recognition site; other site 945713001640 dimerization interface [polypeptide binding]; other site 945713001641 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001643 active site 945713001644 phosphorylation site [posttranslational modification] 945713001645 intermolecular recognition site; other site 945713001646 dimerization interface [polypeptide binding]; other site 945713001647 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713001648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713001649 putative active site [active] 945713001650 heme pocket [chemical binding]; other site 945713001651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001652 dimer interface [polypeptide binding]; other site 945713001653 phosphorylation site [posttranslational modification] 945713001654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001655 ATP binding site [chemical binding]; other site 945713001656 Mg2+ binding site [ion binding]; other site 945713001657 G-X-G motif; other site 945713001658 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 945713001659 putative active site [active] 945713001660 Zn binding site [ion binding]; other site 945713001661 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 945713001662 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 945713001663 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 945713001664 homodimer interface [polypeptide binding]; other site 945713001665 putative substrate binding pocket [chemical binding]; other site 945713001666 diiron center [ion binding]; other site 945713001667 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 945713001668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001669 FeS/SAM binding site; other site 945713001670 HemN C-terminal domain; Region: HemN_C; pfam06969 945713001671 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 945713001672 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 945713001673 substrate binding site [chemical binding]; other site 945713001674 active site 945713001675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713001676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713001677 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 945713001678 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 945713001679 active site 945713001680 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 945713001681 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 945713001682 domain interfaces; other site 945713001683 active site 945713001684 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 945713001685 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 945713001686 tRNA; other site 945713001687 putative tRNA binding site [nucleotide binding]; other site 945713001688 putative NADP binding site [chemical binding]; other site 945713001689 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 945713001690 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 945713001691 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 945713001692 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 945713001693 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 945713001694 Ferritin-like domain; Region: Ferritin; pfam00210 945713001695 dinuclear metal binding motif [ion binding]; other site 945713001696 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 945713001697 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 945713001698 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 945713001699 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 945713001700 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 945713001701 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 945713001702 dimer interface [polypeptide binding]; other site 945713001703 anticodon binding site; other site 945713001704 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 945713001705 homodimer interface [polypeptide binding]; other site 945713001706 motif 1; other site 945713001707 active site 945713001708 motif 2; other site 945713001709 GAD domain; Region: GAD; pfam02938 945713001710 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 945713001711 motif 3; other site 945713001712 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 945713001713 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 945713001714 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 945713001715 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 945713001716 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 945713001717 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 945713001718 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 945713001719 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 945713001720 Walker A motif; other site 945713001721 ATP binding site [chemical binding]; other site 945713001722 Walker B motif; other site 945713001723 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 945713001724 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 945713001725 ATP binding site [chemical binding]; other site 945713001726 Walker B motif; other site 945713001727 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 945713001728 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 945713001729 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001731 active site 945713001732 phosphorylation site [posttranslational modification] 945713001733 intermolecular recognition site; other site 945713001734 dimerization interface [polypeptide binding]; other site 945713001735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945713001736 dimerization interface [polypeptide binding]; other site 945713001737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713001738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001739 dimer interface [polypeptide binding]; other site 945713001740 phosphorylation site [posttranslational modification] 945713001741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001742 ATP binding site [chemical binding]; other site 945713001743 Mg2+ binding site [ion binding]; other site 945713001744 G-X-G motif; other site 945713001745 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001747 active site 945713001748 phosphorylation site [posttranslational modification] 945713001749 intermolecular recognition site; other site 945713001750 dimerization interface [polypeptide binding]; other site 945713001751 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713001752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001753 active site 945713001754 phosphorylation site [posttranslational modification] 945713001755 intermolecular recognition site; other site 945713001756 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001758 active site 945713001759 phosphorylation site [posttranslational modification] 945713001760 intermolecular recognition site; other site 945713001761 dimerization interface [polypeptide binding]; other site 945713001762 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001764 active site 945713001765 phosphorylation site [posttranslational modification] 945713001766 intermolecular recognition site; other site 945713001767 dimerization interface [polypeptide binding]; other site 945713001768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713001769 dimer interface [polypeptide binding]; other site 945713001770 phosphorylation site [posttranslational modification] 945713001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713001772 ATP binding site [chemical binding]; other site 945713001773 Mg2+ binding site [ion binding]; other site 945713001774 G-X-G motif; other site 945713001775 Response regulator receiver domain; Region: Response_reg; pfam00072 945713001776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001777 active site 945713001778 phosphorylation site [posttranslational modification] 945713001779 intermolecular recognition site; other site 945713001780 dimerization interface [polypeptide binding]; other site 945713001781 putative transposase OrfB; Reviewed; Region: PHA02517 945713001782 Homeodomain-like domain; Region: HTH_32; pfam13565 945713001783 Integrase core domain; Region: rve; pfam00665 945713001784 Integrase core domain; Region: rve_3; pfam13683 945713001785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713001786 Transposase; Region: HTH_Tnp_1; pfam01527 945713001787 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713001788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713001789 active site 945713001790 phosphorylation site [posttranslational modification] 945713001791 intermolecular recognition site; other site 945713001792 dimerization interface [polypeptide binding]; other site 945713001793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713001794 Walker A motif; other site 945713001795 ATP binding site [chemical binding]; other site 945713001796 Walker B motif; other site 945713001797 arginine finger; other site 945713001798 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713001799 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 945713001800 Cation efflux family; Region: Cation_efflux; pfam01545 945713001801 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713001802 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713001803 ligand binding site [chemical binding]; other site 945713001804 flexible hinge region; other site 945713001805 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 945713001806 putative switch regulator; other site 945713001807 non-specific DNA interactions [nucleotide binding]; other site 945713001808 DNA binding site [nucleotide binding] 945713001809 sequence specific DNA binding site [nucleotide binding]; other site 945713001810 putative cAMP binding site [chemical binding]; other site 945713001811 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 945713001812 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 945713001813 H-type lectin domain; Region: H_lectin; pfam09458 945713001814 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 945713001815 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 945713001816 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 945713001817 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 945713001818 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 945713001819 active site 945713001820 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 945713001821 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 945713001822 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 945713001823 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 945713001824 putative ribose interaction site [chemical binding]; other site 945713001825 putative ADP binding site [chemical binding]; other site 945713001826 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 945713001827 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 945713001828 active site 945713001829 nucleotide binding site [chemical binding]; other site 945713001830 HIGH motif; other site 945713001831 KMSKS motif; other site 945713001832 Family of unknown function (DUF490); Region: DUF490; pfam04357 945713001833 ribonuclease R; Region: RNase_R; TIGR02063 945713001834 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 945713001835 RNB domain; Region: RNB; pfam00773 945713001836 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 945713001837 RNA binding site [nucleotide binding]; other site 945713001838 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 945713001839 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713001840 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713001841 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713001842 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 945713001843 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 945713001844 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 945713001845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713001846 active site 945713001847 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 945713001848 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 945713001849 5S rRNA interface [nucleotide binding]; other site 945713001850 CTC domain interface [polypeptide binding]; other site 945713001851 L16 interface [polypeptide binding]; other site 945713001852 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 945713001853 putative active site [active] 945713001854 catalytic residue [active] 945713001855 vacuolar-type H(+)-translocating pyrophosphatase; Region: V_PPase; TIGR01104 945713001856 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 945713001857 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 945713001858 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 945713001859 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 945713001860 dimer interface [polypeptide binding]; other site 945713001861 ssDNA binding site [nucleotide binding]; other site 945713001862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945713001863 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 945713001864 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 945713001865 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 945713001866 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 945713001867 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 945713001868 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 945713001869 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 945713001870 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 945713001871 putative NAD(P) binding site [chemical binding]; other site 945713001872 homodimer interface [polypeptide binding]; other site 945713001873 homotetramer interface [polypeptide binding]; other site 945713001874 active site 945713001875 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 945713001876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001877 FeS/SAM binding site; other site 945713001878 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 945713001879 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 945713001880 domain interfaces; other site 945713001881 active site 945713001882 AAA domain; Region: AAA_32; pfam13654 945713001883 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 945713001884 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 945713001885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 945713001886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713001887 catalytic residue [active] 945713001888 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 945713001889 phosphomannomutase CpsG; Provisional; Region: PRK15414 945713001890 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 945713001891 active site 945713001892 substrate binding site [chemical binding]; other site 945713001893 metal binding site [ion binding]; metal-binding site 945713001894 Peptidase S46; Region: Peptidase_S46; pfam10459 945713001895 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 945713001896 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 945713001897 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 945713001898 structural tetrad; other site 945713001899 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 945713001900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713001901 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 945713001902 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 945713001903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001904 FeS/SAM binding site; other site 945713001905 TRAM domain; Region: TRAM; pfam01938 945713001906 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713001907 Sporulation related domain; Region: SPOR; pfam05036 945713001908 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 945713001909 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 945713001910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713001911 Walker A motif; other site 945713001912 ATP binding site [chemical binding]; other site 945713001913 Walker B motif; other site 945713001914 arginine finger; other site 945713001915 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713001916 Lipopolysaccharide-assembly; Region: LptE; pfam04390 945713001917 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 945713001918 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 945713001919 DXD motif; other site 945713001920 TPR repeat; Region: TPR_11; pfam13414 945713001921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713001922 TPR motif; other site 945713001923 binding surface 945713001924 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 945713001925 active site 945713001926 DNA binding site [nucleotide binding] 945713001927 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713001928 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713001929 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713001930 putative active site [active] 945713001931 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 945713001932 CAAX protease self-immunity; Region: Abi; pfam02517 945713001933 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 945713001934 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 945713001935 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 945713001936 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 945713001937 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 945713001938 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 945713001939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713001940 FeS/SAM binding site; other site 945713001941 Helix-turn-helix domain; Region: HTH_17; pfam12728 945713001942 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 945713001943 DNA methylase; Region: N6_N4_Mtase; pfam01555 945713001944 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 945713001945 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 945713001946 putative substrate binding site [chemical binding]; other site 945713001947 putative ATP binding site [chemical binding]; other site 945713001948 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 945713001949 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713001950 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 945713001951 UbiA prenyltransferase family; Region: UbiA; pfam01040 945713001952 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 945713001953 RNA/DNA hybrid binding site [nucleotide binding]; other site 945713001954 active site 945713001955 hypothetical protein; Reviewed; Region: PRK12497 945713001956 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 945713001957 Permease; Region: Permease; pfam02405 945713001958 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 945713001959 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 945713001960 Walker A/P-loop; other site 945713001961 ATP binding site [chemical binding]; other site 945713001962 Q-loop/lid; other site 945713001963 ABC transporter signature motif; other site 945713001964 Walker B; other site 945713001965 D-loop; other site 945713001966 H-loop/switch region; other site 945713001967 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 945713001968 mce related protein; Region: MCE; pfam02470 945713001969 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 945713001970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945713001971 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945713001972 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 945713001973 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 945713001974 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 945713001975 putative active site [active] 945713001976 putative metal binding site [ion binding]; other site 945713001977 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713001978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 945713001979 Sm and related proteins; Region: Sm_like; cl00259 945713001980 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 945713001981 putative oligomer interface [polypeptide binding]; other site 945713001982 putative RNA binding site [nucleotide binding]; other site 945713001983 transcription termination factor NusA; Region: NusA; TIGR01953 945713001984 NusA N-terminal domain; Region: NusA_N; pfam08529 945713001985 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 945713001986 RNA binding site [nucleotide binding]; other site 945713001987 homodimer interface [polypeptide binding]; other site 945713001988 NusA-like KH domain; Region: KH_5; pfam13184 945713001989 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 945713001990 G-X-X-G motif; other site 945713001991 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 945713001992 translation initiation factor IF-2; Region: IF-2; TIGR00487 945713001993 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 945713001994 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 945713001995 G1 box; other site 945713001996 putative GEF interaction site [polypeptide binding]; other site 945713001997 GTP/Mg2+ binding site [chemical binding]; other site 945713001998 Switch I region; other site 945713001999 G2 box; other site 945713002000 G3 box; other site 945713002001 Switch II region; other site 945713002002 G4 box; other site 945713002003 G5 box; other site 945713002004 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 945713002005 Translation-initiation factor 2; Region: IF-2; pfam11987 945713002006 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 945713002007 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 945713002008 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 945713002009 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 945713002010 RNA binding site [nucleotide binding]; other site 945713002011 active site 945713002012 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 945713002013 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 945713002014 active site 945713002015 Riboflavin kinase; Region: Flavokinase; smart00904 945713002016 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 945713002017 16S/18S rRNA binding site [nucleotide binding]; other site 945713002018 S13e-L30e interaction site [polypeptide binding]; other site 945713002019 25S rRNA binding site [nucleotide binding]; other site 945713002020 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 945713002021 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 945713002022 RNase E interface [polypeptide binding]; other site 945713002023 trimer interface [polypeptide binding]; other site 945713002024 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 945713002025 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 945713002026 RNase E interface [polypeptide binding]; other site 945713002027 trimer interface [polypeptide binding]; other site 945713002028 active site 945713002029 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 945713002030 putative nucleic acid binding region [nucleotide binding]; other site 945713002031 G-X-X-G motif; other site 945713002032 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 945713002033 RNA binding site [nucleotide binding]; other site 945713002034 domain interface; other site 945713002035 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 945713002036 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 945713002037 homodimer interface [polypeptide binding]; other site 945713002038 oligonucleotide binding site [chemical binding]; other site 945713002039 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 945713002040 active site 945713002041 intersubunit interactions; other site 945713002042 catalytic residue [active] 945713002043 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 945713002044 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 945713002045 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 945713002046 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 945713002047 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 945713002048 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 945713002049 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 945713002050 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 945713002051 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 945713002052 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 945713002053 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 945713002054 Bacitracin resistance protein BacA; Region: BacA; pfam02673 945713002055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 945713002056 active site 945713002057 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 945713002058 Na2 binding site [ion binding]; other site 945713002059 putative substrate binding site 1 [chemical binding]; other site 945713002060 Na binding site 1 [ion binding]; other site 945713002061 putative substrate binding site 2 [chemical binding]; other site 945713002062 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 945713002063 DNA polymerase III, delta subunit; Region: holA; TIGR01128 945713002064 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 945713002065 Domain of unknown function DUF20; Region: UPF0118; pfam01594 945713002066 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 945713002067 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 945713002068 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 945713002069 Walker A motif; other site 945713002070 polyphosphate kinase; Provisional; Region: PRK05443 945713002071 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 945713002072 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 945713002073 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 945713002074 putative domain interface [polypeptide binding]; other site 945713002075 putative active site [active] 945713002076 catalytic site [active] 945713002077 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 945713002078 putative domain interface [polypeptide binding]; other site 945713002079 putative active site [active] 945713002080 catalytic site [active] 945713002081 Cation transport protein; Region: TrkH; cl17365 945713002082 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 945713002083 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 945713002084 TrkA-N domain; Region: TrkA_N; pfam02254 945713002085 TrkA-C domain; Region: TrkA_C; pfam02080 945713002086 TrkA-N domain; Region: TrkA_N; pfam02254 945713002087 TrkA-C domain; Region: TrkA_C; pfam02080 945713002088 Deoxyhypusine synthase; Region: DS; cl00826 945713002089 deoxyhypusine synthase; Region: dhys; TIGR00321 945713002090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713002091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713002092 NAD(P) binding site [chemical binding]; other site 945713002093 active site 945713002094 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713002095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713002096 DNA binding residues [nucleotide binding] 945713002097 dimerization interface [polypeptide binding]; other site 945713002098 Methylamine utilisation protein MauE; Region: MauE; pfam07291 945713002099 Methylamine utilisation protein MauE; Region: MauE; pfam07291 945713002100 O-Antigen ligase; Region: Wzy_C; pfam04932 945713002101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713002102 Transposase; Region: HTH_Tnp_1; pfam01527 945713002103 putative transposase OrfB; Reviewed; Region: PHA02517 945713002104 Homeodomain-like domain; Region: HTH_32; pfam13565 945713002105 Integrase core domain; Region: rve; pfam00665 945713002106 Integrase core domain; Region: rve_3; pfam13683 945713002107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713002108 Transposase; Region: HTH_Tnp_1; pfam01527 945713002109 Winged helix-turn helix; Region: HTH_29; pfam13551 945713002110 Homeodomain-like domain; Region: HTH_32; pfam13565 945713002111 Integrase core domain; Region: rve; pfam00665 945713002112 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 945713002113 Peptidase family M23; Region: Peptidase_M23; pfam01551 945713002114 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 945713002115 Protein export membrane protein; Region: SecD_SecF; cl14618 945713002116 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713002117 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 945713002118 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713002119 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 945713002120 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 945713002121 23S rRNA interface [nucleotide binding]; other site 945713002122 L3 interface [polypeptide binding]; other site 945713002123 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 945713002124 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 945713002125 rRNA interaction site [nucleotide binding]; other site 945713002126 S8 interaction site; other site 945713002127 putative laminin-1 binding site; other site 945713002128 elongation factor Ts; Provisional; Region: tsf; PRK09377 945713002129 UBA/TS-N domain; Region: UBA; pfam00627 945713002130 Elongation factor TS; Region: EF_TS; pfam00889 945713002131 Elongation factor TS; Region: EF_TS; pfam00889 945713002132 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 945713002133 putative nucleotide binding site [chemical binding]; other site 945713002134 uridine monophosphate binding site [chemical binding]; other site 945713002135 homohexameric interface [polypeptide binding]; other site 945713002136 ribosome recycling factor; Reviewed; Region: frr; PRK00083 945713002137 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 945713002138 hinge region; other site 945713002139 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713002140 Interdomain contacts; other site 945713002141 Cytokine receptor motif; other site 945713002142 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002143 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713002144 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713002145 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002146 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945713002147 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945713002148 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 945713002149 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713002150 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713002151 hypothetical protein; Provisional; Region: PRK11820 945713002152 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 945713002153 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 945713002154 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 945713002155 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 945713002156 catalytic site [active] 945713002157 G-X2-G-X-G-K; other site 945713002158 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 945713002159 Fe-S cluster binding site [ion binding]; other site 945713002160 active site 945713002161 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 945713002162 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 945713002163 Walker A motif; other site 945713002164 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 945713002165 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 945713002166 protein-splicing catalytic site; other site 945713002167 thioester formation/cholesterol transfer; other site 945713002168 Homing endonuclease; Region: Hom_end; pfam05204 945713002169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 945713002170 ATP binding site [chemical binding]; other site 945713002171 Walker B motif; other site 945713002172 DNA binding loops [nucleotide binding] 945713002173 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 945713002174 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945713002175 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 945713002176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713002177 NAD(P) binding site [chemical binding]; other site 945713002178 active site 945713002179 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 945713002180 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 945713002181 NAD binding site [chemical binding]; other site 945713002182 substrate binding site [chemical binding]; other site 945713002183 homodimer interface [polypeptide binding]; other site 945713002184 active site 945713002185 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 945713002186 SLBB domain; Region: SLBB; pfam10531 945713002187 SLBB domain; Region: SLBB; pfam10531 945713002188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713002189 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 945713002190 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 945713002191 active site 945713002192 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 945713002193 active site 945713002194 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 945713002195 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 945713002196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945713002197 Soluble P-type ATPase [General function prediction only]; Region: COG4087 945713002198 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 945713002199 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 945713002200 Low-spin heme binding site [chemical binding]; other site 945713002201 Putative water exit pathway; other site 945713002202 Binuclear center (active site) [active] 945713002203 Putative proton exit pathway; other site 945713002204 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 945713002205 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 945713002206 Cytochrome c; Region: Cytochrom_C; pfam00034 945713002207 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 945713002208 4Fe-4S binding domain; Region: Fer4_5; pfam12801 945713002209 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 945713002210 FixH; Region: FixH; pfam05751 945713002211 Family description; Region: DsbD_2; pfam13386 945713002212 AAA domain; Region: AAA_14; pfam13173 945713002213 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 945713002214 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 945713002215 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 945713002216 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 945713002217 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 945713002218 active site 945713002219 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 945713002220 FAD binding site [chemical binding]; other site 945713002221 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 945713002222 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 945713002223 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 945713002224 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 945713002225 intersubunit interface [polypeptide binding]; other site 945713002226 active site 945713002227 Zn2+ binding site [ion binding]; other site 945713002228 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 945713002229 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 945713002230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713002231 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 945713002232 Septum formation initiator; Region: DivIC; pfam04977 945713002233 recombination factor protein RarA; Reviewed; Region: PRK13342 945713002234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713002235 Walker A motif; other site 945713002236 ATP binding site [chemical binding]; other site 945713002237 Walker B motif; other site 945713002238 arginine finger; other site 945713002239 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 945713002240 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 945713002241 DNA protecting protein DprA; Region: dprA; TIGR00732 945713002242 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 945713002243 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 945713002244 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 945713002245 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 945713002246 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 945713002247 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 945713002248 Probable Catalytic site; other site 945713002249 metal-binding site 945713002250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713002251 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 945713002252 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 945713002253 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 945713002254 Probable Catalytic site; other site 945713002255 metal-binding site 945713002256 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 945713002257 Bacterial sugar transferase; Region: Bac_transf; pfam02397 945713002258 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 945713002259 Ligand binding site; other site 945713002260 DXD motif; other site 945713002261 Putative Catalytic site; other site 945713002262 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 945713002263 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 945713002264 Probable Catalytic site; other site 945713002265 metal-binding site 945713002266 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 945713002267 Bacterial sugar transferase; Region: Bac_transf; cl00939 945713002268 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 945713002269 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 945713002270 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945713002271 active site 945713002272 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 945713002273 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 945713002274 dimerization interface [polypeptide binding]; other site 945713002275 active site 945713002276 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 945713002277 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 945713002278 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 945713002279 trimer interface [polypeptide binding]; other site 945713002280 active site 945713002281 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 945713002282 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 945713002283 active site 945713002284 PHP Thumb interface [polypeptide binding]; other site 945713002285 metal binding site [ion binding]; metal-binding site 945713002286 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 945713002287 generic binding surface II; other site 945713002288 generic binding surface I; other site 945713002289 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 945713002290 classical (c) SDRs; Region: SDR_c; cd05233 945713002291 NAD(P) binding site [chemical binding]; other site 945713002292 active site 945713002293 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713002294 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713002295 catalytic residues [active] 945713002296 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 945713002297 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 945713002298 ligand binding site [chemical binding]; other site 945713002299 NAD binding site [chemical binding]; other site 945713002300 dimerization interface [polypeptide binding]; other site 945713002301 catalytic site [active] 945713002302 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 945713002303 putative L-serine binding site [chemical binding]; other site 945713002304 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002305 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713002306 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713002307 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713002308 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713002309 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 945713002310 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 945713002311 putative acyl-acceptor binding pocket; other site 945713002312 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713002313 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713002314 putative active site [active] 945713002315 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 945713002316 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 945713002317 Peptidase family M23; Region: Peptidase_M23; pfam01551 945713002318 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 945713002319 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 945713002320 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 945713002321 ATP synthase A chain; Region: ATP-synt_A; cl00413 945713002322 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 945713002323 ATP synthase subunit C; Region: ATP-synt_C; cl00466 945713002324 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 945713002325 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 945713002326 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 945713002327 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 945713002328 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 945713002329 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 945713002330 beta subunit interaction interface [polypeptide binding]; other site 945713002331 Walker A motif; other site 945713002332 ATP binding site [chemical binding]; other site 945713002333 Walker B motif; other site 945713002334 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 945713002335 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 945713002336 core domain interface [polypeptide binding]; other site 945713002337 delta subunit interface [polypeptide binding]; other site 945713002338 epsilon subunit interface [polypeptide binding]; other site 945713002339 signal recognition particle protein; Provisional; Region: PRK10867 945713002340 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 945713002341 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 945713002342 P loop; other site 945713002343 GTP binding site [chemical binding]; other site 945713002344 Signal peptide binding domain; Region: SRP_SPB; pfam02978 945713002345 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 945713002346 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 945713002347 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 945713002348 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 945713002349 RimM N-terminal domain; Region: RimM; pfam01782 945713002350 PRC-barrel domain; Region: PRC; pfam05239 945713002351 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 945713002352 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 945713002353 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc; pfam03364 945713002354 hydrophobic ligand binding site; other site 945713002355 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 945713002356 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 945713002357 putative ligand binding site [chemical binding]; other site 945713002358 putative NAD binding site [chemical binding]; other site 945713002359 putative catalytic site [active] 945713002360 urocanate hydratase; Provisional; Region: PRK05414 945713002361 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 945713002362 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 945713002363 active site 945713002364 purine riboside binding site [chemical binding]; other site 945713002365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002366 TPR repeat; Region: TPR_11; pfam13414 945713002367 TPR motif; other site 945713002368 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713002369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002370 binding surface 945713002371 TPR motif; other site 945713002372 TPR repeat; Region: TPR_11; pfam13414 945713002373 TPR repeat; Region: TPR_11; pfam13414 945713002374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002375 binding surface 945713002376 TPR motif; other site 945713002377 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 945713002378 Predicted permeases [General function prediction only]; Region: COG0795 945713002379 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 945713002380 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 945713002381 Predicted permeases [General function prediction only]; Region: COG0795 945713002382 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 945713002383 hypothetical protein; Provisional; Region: PRK08201 945713002384 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 945713002385 metal binding site [ion binding]; metal-binding site 945713002386 putative dimer interface [polypeptide binding]; other site 945713002387 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 945713002388 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 945713002389 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 945713002390 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 945713002391 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 945713002392 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 945713002393 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 945713002394 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 945713002395 Transmembrane secretion effector; Region: MFS_3; pfam05977 945713002396 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713002397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002398 TPR motif; other site 945713002399 binding surface 945713002400 TPR repeat; Region: TPR_11; pfam13414 945713002401 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 945713002402 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 945713002403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 945713002404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713002405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713002406 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 945713002407 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 945713002408 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 945713002409 active site 945713002410 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 945713002411 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713002412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713002413 binding surface 945713002414 TPR motif; other site 945713002415 elongation factor P; Validated; Region: PRK00529 945713002416 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 945713002417 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 945713002418 RNA binding site [nucleotide binding]; other site 945713002419 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 945713002420 RNA binding site [nucleotide binding]; other site 945713002421 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 945713002422 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945713002423 carboxyltransferase (CT) interaction site; other site 945713002424 biotinylation site [posttranslational modification]; other site 945713002425 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 945713002426 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945713002427 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 945713002428 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 945713002429 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 945713002430 lipoyl attachment site [posttranslational modification]; other site 945713002431 GMP synthase; Reviewed; Region: guaA; PRK00074 945713002432 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 945713002433 AMP/PPi binding site [chemical binding]; other site 945713002434 candidate oxyanion hole; other site 945713002435 catalytic triad [active] 945713002436 potential glutamine specificity residues [chemical binding]; other site 945713002437 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 945713002438 ATP Binding subdomain [chemical binding]; other site 945713002439 Ligand Binding sites [chemical binding]; other site 945713002440 Dimerization subdomain; other site 945713002441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713002442 binding surface 945713002443 TPR motif; other site 945713002444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002445 TPR motif; other site 945713002446 binding surface 945713002447 TPR repeat; Region: TPR_11; pfam13414 945713002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 945713002449 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 945713002450 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 945713002451 ligand binding site [chemical binding]; other site 945713002452 hypothetical protein; Reviewed; Region: PRK00024 945713002453 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 945713002454 MPN+ (JAMM) motif; other site 945713002455 Zinc-binding site [ion binding]; other site 945713002456 Rice tungro bacilliform virus P46 protein; Region: RTBV_P46; pfam06216 945713002457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713002458 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 945713002459 PhoH-like protein; Region: PhoH; pfam02562 945713002460 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 945713002461 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 945713002462 homodimer interface [polypeptide binding]; other site 945713002463 metal binding site [ion binding]; metal-binding site 945713002464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 945713002465 homodimer interface [polypeptide binding]; other site 945713002466 active site 945713002467 putative chemical substrate binding site [chemical binding]; other site 945713002468 metal binding site [ion binding]; metal-binding site 945713002469 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 945713002470 homotrimer interaction site [polypeptide binding]; other site 945713002471 putative active site [active] 945713002472 shikimate kinase; Reviewed; Region: aroK; PRK00131 945713002473 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 945713002474 ADP binding site [chemical binding]; other site 945713002475 magnesium binding site [ion binding]; other site 945713002476 putative shikimate binding site; other site 945713002477 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 945713002478 active site 945713002479 dimer interface [polypeptide binding]; other site 945713002480 metal binding site [ion binding]; metal-binding site 945713002481 quinolinate synthetase; Provisional; Region: PRK09375 945713002482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713002483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713002484 phosphorylation site [posttranslational modification] 945713002485 dimer interface [polypeptide binding]; other site 945713002486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713002487 ATP binding site [chemical binding]; other site 945713002488 Mg2+ binding site [ion binding]; other site 945713002489 G-X-G motif; other site 945713002490 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 945713002491 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 945713002492 GDP-binding site [chemical binding]; other site 945713002493 ACT binding site; other site 945713002494 IMP binding site; other site 945713002495 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713002496 anti sigma factor interaction site; other site 945713002497 regulatory phosphorylation site [posttranslational modification]; other site 945713002498 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 945713002499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713002500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713002501 DNA binding residues [nucleotide binding] 945713002502 Predicted membrane protein [Function unknown]; Region: COG4267 945713002503 GAF domain; Region: GAF_3; pfam13492 945713002504 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713002505 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713002506 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713002507 anti sigma factor interaction site; other site 945713002508 regulatory phosphorylation site [posttranslational modification]; other site 945713002509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 945713002510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713002511 ATP binding site [chemical binding]; other site 945713002512 Mg2+ binding site [ion binding]; other site 945713002513 G-X-G motif; other site 945713002514 GAF domain; Region: GAF; cl17456 945713002515 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713002516 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713002517 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 945713002518 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 945713002519 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713002520 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713002521 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 945713002522 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 945713002523 active site 945713002524 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945713002525 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 945713002526 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 945713002527 Protein export membrane protein; Region: SecD_SecF; pfam02355 945713002528 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 945713002529 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 945713002530 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 945713002531 purine nucleoside phosphorylase; Provisional; Region: PRK08202 945713002532 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 945713002533 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 945713002534 Nucleoside recognition; Region: Gate; pfam07670 945713002535 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 945713002536 thymidine kinase; Provisional; Region: PRK04296 945713002537 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 945713002538 active site 945713002539 catalytic motif [active] 945713002540 Zn binding site [ion binding]; other site 945713002541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713002542 S-adenosylmethionine binding site [chemical binding]; other site 945713002543 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713002544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713002545 active site 945713002546 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002547 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 945713002548 Asp-box motif; other site 945713002549 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002550 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 945713002551 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 945713002552 dimerization interface [polypeptide binding]; other site 945713002553 ATP binding site [chemical binding]; other site 945713002554 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 945713002555 dimerization interface [polypeptide binding]; other site 945713002556 ATP binding site [chemical binding]; other site 945713002557 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 945713002558 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002559 Cytochrome c; Region: Cytochrom_C; cl11414 945713002560 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 945713002561 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 945713002562 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 945713002563 NosL; Region: NosL; cl01769 945713002564 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 945713002565 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 945713002566 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 945713002567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945713002568 Walker A/P-loop; other site 945713002569 ATP binding site [chemical binding]; other site 945713002570 Q-loop/lid; other site 945713002571 ABC transporter signature motif; other site 945713002572 Walker B; other site 945713002573 D-loop; other site 945713002574 H-loop/switch region; other site 945713002575 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 945713002576 Rrf2 family protein; Region: rrf2_super; TIGR00738 945713002577 Transcriptional regulator; Region: Rrf2; pfam02082 945713002578 4Fe-4S binding domain; Region: Fer4_5; pfam12801 945713002579 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 945713002580 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713002581 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 945713002582 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 945713002583 Hemerythrin-like domain; Region: Hr-like; cd12108 945713002584 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 945713002585 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 945713002586 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 945713002587 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 945713002588 Outer membrane efflux protein; Region: OEP; pfam02321 945713002589 Outer membrane efflux protein; Region: OEP; pfam02321 945713002590 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 945713002591 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713002592 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 945713002593 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 945713002594 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 945713002595 GTP cyclohydrolase I; Provisional; Region: PLN03044 945713002596 active site 945713002597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713002598 binding surface 945713002599 TPR motif; other site 945713002600 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713002601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713002602 binding surface 945713002603 TPR motif; other site 945713002604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 945713002605 active site 945713002606 phosphorylation site [posttranslational modification] 945713002607 histidyl-tRNA synthetase; Region: hisS; TIGR00442 945713002608 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 945713002609 dimer interface [polypeptide binding]; other site 945713002610 motif 1; other site 945713002611 active site 945713002612 motif 2; other site 945713002613 motif 3; other site 945713002614 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 945713002615 anticodon binding site; other site 945713002616 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 945713002617 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 945713002618 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945713002619 Transposase, Mutator family; Region: Transposase_mut; pfam00872 945713002620 MULE transposase domain; Region: MULE; pfam10551 945713002621 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 945713002622 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 945713002623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945713002624 Histidine kinase; Region: HisKA_3; pfam07730 945713002625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713002626 ATP binding site [chemical binding]; other site 945713002627 Mg2+ binding site [ion binding]; other site 945713002628 G-X-G motif; other site 945713002629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713002630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713002631 active site 945713002632 phosphorylation site [posttranslational modification] 945713002633 intermolecular recognition site; other site 945713002634 dimerization interface [polypeptide binding]; other site 945713002635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713002636 DNA binding residues [nucleotide binding] 945713002637 dimerization interface [polypeptide binding]; other site 945713002638 Transposase, Mutator family; Region: Transposase_mut; pfam00872 945713002639 MULE transposase domain; Region: MULE; pfam10551 945713002640 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 945713002641 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 945713002642 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713002643 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713002645 Transposase; Region: HTH_Tnp_1; pfam01527 945713002646 putative transposase OrfB; Reviewed; Region: PHA02517 945713002647 Integrase core domain; Region: rve; pfam00665 945713002648 Integrase core domain; Region: rve_3; pfam13683 945713002649 Transposase, Mutator family; Region: Transposase_mut; pfam00872 945713002650 Transposase, Mutator family; Region: Transposase_mut; pfam00872 945713002651 Transposase, Mutator family; Region: Transposase_mut; pfam00872 945713002652 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713002653 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713002654 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 945713002655 Double zinc ribbon; Region: DZR; pfam12773 945713002656 aminotransferase AlaT; Validated; Region: PRK09265 945713002657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713002658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713002659 homodimer interface [polypeptide binding]; other site 945713002660 catalytic residue [active] 945713002661 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713002662 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713002663 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713002664 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 945713002665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 945713002666 catalytic loop [active] 945713002667 iron binding site [ion binding]; other site 945713002668 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 945713002669 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 945713002670 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 945713002671 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 945713002672 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 945713002673 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 945713002674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713002675 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 945713002676 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 945713002677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713002678 Walker A motif; other site 945713002679 ATP binding site [chemical binding]; other site 945713002680 Walker B motif; other site 945713002681 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 945713002682 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 945713002683 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 945713002684 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 945713002685 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 945713002686 putative homodimer interface [polypeptide binding]; other site 945713002687 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 945713002688 heterodimer interface [polypeptide binding]; other site 945713002689 homodimer interface [polypeptide binding]; other site 945713002690 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 945713002691 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 945713002692 23S rRNA interface [nucleotide binding]; other site 945713002693 L7/L12 interface [polypeptide binding]; other site 945713002694 putative thiostrepton binding site; other site 945713002695 L25 interface [polypeptide binding]; other site 945713002696 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 945713002697 mRNA/rRNA interface [nucleotide binding]; other site 945713002698 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 945713002699 23S rRNA interface [nucleotide binding]; other site 945713002700 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 945713002701 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 945713002702 L11 interface [polypeptide binding]; other site 945713002703 putative EF-Tu interaction site [polypeptide binding]; other site 945713002704 putative EF-G interaction site [polypeptide binding]; other site 945713002705 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 945713002706 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 945713002707 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 945713002708 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 945713002709 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 945713002710 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 945713002711 RPB12 interaction site [polypeptide binding]; other site 945713002712 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 945713002713 RPB3 interaction site [polypeptide binding]; other site 945713002714 RPB1 interaction site [polypeptide binding]; other site 945713002715 RPB11 interaction site [polypeptide binding]; other site 945713002716 RPB10 interaction site [polypeptide binding]; other site 945713002717 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 945713002718 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 945713002719 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 945713002720 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 945713002721 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 945713002722 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 945713002723 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 945713002724 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 945713002725 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 945713002726 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 945713002727 DNA binding site [nucleotide binding] 945713002728 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 945713002729 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 945713002730 S17 interaction site [polypeptide binding]; other site 945713002731 S8 interaction site; other site 945713002732 16S rRNA interaction site [nucleotide binding]; other site 945713002733 streptomycin interaction site [chemical binding]; other site 945713002734 23S rRNA interaction site [nucleotide binding]; other site 945713002735 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 945713002736 30S ribosomal protein S7; Validated; Region: PRK05302 945713002737 elongation factor G; Reviewed; Region: PRK00007 945713002738 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 945713002739 G1 box; other site 945713002740 putative GEF interaction site [polypeptide binding]; other site 945713002741 GTP/Mg2+ binding site [chemical binding]; other site 945713002742 Switch I region; other site 945713002743 G2 box; other site 945713002744 G3 box; other site 945713002745 Switch II region; other site 945713002746 G4 box; other site 945713002747 G5 box; other site 945713002748 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 945713002749 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 945713002750 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 945713002751 elongation factor Tu; Reviewed; Region: PRK00049 945713002752 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 945713002753 G1 box; other site 945713002754 GEF interaction site [polypeptide binding]; other site 945713002755 GTP/Mg2+ binding site [chemical binding]; other site 945713002756 Switch I region; other site 945713002757 G2 box; other site 945713002758 G3 box; other site 945713002759 Switch II region; other site 945713002760 G4 box; other site 945713002761 G5 box; other site 945713002762 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 945713002763 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 945713002764 Antibiotic Binding Site [chemical binding]; other site 945713002765 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 945713002766 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 945713002767 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 945713002768 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 945713002769 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 945713002770 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 945713002771 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 945713002772 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 945713002773 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 945713002774 putative translocon binding site; other site 945713002775 protein-rRNA interface [nucleotide binding]; other site 945713002776 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 945713002777 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 945713002778 G-X-X-G motif; other site 945713002779 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 945713002780 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 945713002781 23S rRNA interface [nucleotide binding]; other site 945713002782 5S rRNA interface [nucleotide binding]; other site 945713002783 putative antibiotic binding site [chemical binding]; other site 945713002784 L25 interface [polypeptide binding]; other site 945713002785 L27 interface [polypeptide binding]; other site 945713002786 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 945713002787 putative translocon interaction site; other site 945713002788 23S rRNA interface [nucleotide binding]; other site 945713002789 signal recognition particle (SRP54) interaction site; other site 945713002790 L23 interface [polypeptide binding]; other site 945713002791 trigger factor interaction site; other site 945713002792 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 945713002793 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 945713002794 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 945713002795 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 945713002796 RNA binding site [nucleotide binding]; other site 945713002797 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 945713002798 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 945713002799 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 945713002800 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 945713002801 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 945713002802 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 945713002803 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 945713002804 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 945713002805 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 945713002806 5S rRNA interface [nucleotide binding]; other site 945713002807 L27 interface [polypeptide binding]; other site 945713002808 23S rRNA interface [nucleotide binding]; other site 945713002809 L5 interface [polypeptide binding]; other site 945713002810 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 945713002811 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 945713002812 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 945713002813 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 945713002814 23S rRNA binding site [nucleotide binding]; other site 945713002815 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 945713002816 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 945713002817 SecY translocase; Region: SecY; pfam00344 945713002818 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 945713002819 active site 945713002820 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 945713002821 rRNA binding site [nucleotide binding]; other site 945713002822 predicted 30S ribosome binding site; other site 945713002823 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 945713002824 30S ribosomal protein S13; Region: bact_S13; TIGR03631 945713002825 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 945713002826 30S ribosomal protein S11; Validated; Region: PRK05309 945713002827 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 945713002828 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 945713002829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945713002830 RNA binding surface [nucleotide binding]; other site 945713002831 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 945713002832 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 945713002833 alphaNTD homodimer interface [polypeptide binding]; other site 945713002834 alphaNTD - beta interaction site [polypeptide binding]; other site 945713002835 alphaNTD - beta' interaction site [polypeptide binding]; other site 945713002836 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 945713002837 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 945713002838 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 945713002839 G1 box; other site 945713002840 GTP/Mg2+ binding site [chemical binding]; other site 945713002841 Switch I region; other site 945713002842 G2 box; other site 945713002843 G3 box; other site 945713002844 Switch II region; other site 945713002845 G4 box; other site 945713002846 G5 box; other site 945713002847 GAF domain; Region: GAF; pfam01590 945713002848 GAF domain; Region: GAF_2; pfam13185 945713002849 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 945713002850 GAF domain; Region: GAF_2; pfam13185 945713002851 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 945713002852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 945713002853 metal binding site [ion binding]; metal-binding site 945713002854 active site 945713002855 I-site; other site 945713002856 phosphopentomutase; Provisional; Region: PRK05362 945713002857 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 945713002858 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 945713002859 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 945713002860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713002861 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 945713002862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713002863 DNA binding residues [nucleotide binding] 945713002864 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945713002865 NlpC/P60 family; Region: NLPC_P60; pfam00877 945713002866 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 945713002867 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 945713002868 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 945713002869 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 945713002870 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 945713002871 TSCPD domain; Region: TSCPD; pfam12637 945713002872 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945713002873 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 945713002874 Walker A/P-loop; other site 945713002875 ATP binding site [chemical binding]; other site 945713002876 Q-loop/lid; other site 945713002877 ABC transporter signature motif; other site 945713002878 Walker B; other site 945713002879 D-loop; other site 945713002880 H-loop/switch region; other site 945713002881 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 945713002882 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 945713002883 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 945713002884 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 945713002885 dimer interface [polypeptide binding]; other site 945713002886 active site 945713002887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 945713002888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713002889 Coenzyme A binding pocket [chemical binding]; other site 945713002890 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 945713002891 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 945713002892 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 945713002893 active site 945713002894 PAS domain S-box; Region: sensory_box; TIGR00229 945713002895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713002896 putative active site [active] 945713002897 heme pocket [chemical binding]; other site 945713002898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713002899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713002900 dimer interface [polypeptide binding]; other site 945713002901 phosphorylation site [posttranslational modification] 945713002902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713002903 ATP binding site [chemical binding]; other site 945713002904 Mg2+ binding site [ion binding]; other site 945713002905 G-X-G motif; other site 945713002906 Response regulator receiver domain; Region: Response_reg; pfam00072 945713002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713002908 active site 945713002909 phosphorylation site [posttranslational modification] 945713002910 intermolecular recognition site; other site 945713002911 dimerization interface [polypeptide binding]; other site 945713002912 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 945713002913 putative binding surface; other site 945713002914 active site 945713002915 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 945713002916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945713002917 inhibitor-cofactor binding pocket; inhibition site 945713002918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713002919 catalytic residue [active] 945713002920 Uncharacterized conserved protein [Function unknown]; Region: COG0432 945713002921 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 945713002922 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 945713002923 active site 945713002924 catalytic site [active] 945713002925 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002926 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 945713002927 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 945713002928 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945713002929 Protein of unknown function (DUF971); Region: DUF971; pfam06155 945713002930 Domain of unknown function DUF21; Region: DUF21; pfam01595 945713002931 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 945713002932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945713002933 Transporter associated domain; Region: CorC_HlyC; smart01091 945713002934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 945713002935 Uncharacterized conserved protein [Function unknown]; Region: COG1262 945713002936 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 945713002937 Caspase domain; Region: Peptidase_C14; pfam00656 945713002938 Caspase domain; Region: Peptidase_C14; pfam00656 945713002939 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 945713002940 active site 945713002941 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 945713002942 CHASE2 domain; Region: CHASE2; pfam05226 945713002943 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713002944 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713002945 FAD binding domain; Region: FAD_binding_4; pfam01565 945713002946 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 945713002947 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713002948 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 945713002949 Cysteine-rich domain; Region: CCG; pfam02754 945713002950 Cysteine-rich domain; Region: CCG; pfam02754 945713002951 diaminopimelate decarboxylase; Region: lysA; TIGR01048 945713002952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 945713002953 active site 945713002954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945713002955 substrate binding site [chemical binding]; other site 945713002956 catalytic residues [active] 945713002957 dimer interface [polypeptide binding]; other site 945713002958 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 945713002959 amidase catalytic site [active] 945713002960 Zn binding residues [ion binding]; other site 945713002961 substrate binding site [chemical binding]; other site 945713002962 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 945713002963 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 945713002964 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 945713002965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713002966 nucleotide binding site [chemical binding]; other site 945713002967 muropeptide transporter; Validated; Region: ampG; cl17669 945713002968 muropeptide transporter; Validated; Region: ampG; cl17669 945713002969 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 945713002970 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 945713002971 active site 945713002972 Zn binding site [ion binding]; other site 945713002973 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 945713002974 NlpC/P60 family; Region: NLPC_P60; pfam00877 945713002975 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 945713002976 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 945713002977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 945713002978 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 945713002979 YcfA-like protein; Region: YcfA; pfam07927 945713002980 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 945713002981 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 945713002982 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713002983 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 945713002984 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 945713002985 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 945713002986 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 945713002987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713002988 active site 945713002989 metal binding site [ion binding]; metal-binding site 945713002990 PQQ-like domain; Region: PQQ_2; pfam13360 945713002991 YWTD domain; Region: YWTD; pfam13570 945713002992 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 945713002993 active site 945713002994 Trp docking motif [polypeptide binding]; other site 945713002995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945713002996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945713002997 active site 945713002998 catalytic tetrad [active] 945713002999 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003000 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 945713003001 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 945713003002 active site 945713003003 metal binding site [ion binding]; metal-binding site 945713003004 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713003005 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713003006 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003007 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 945713003008 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 945713003009 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713003010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 945713003011 active site 945713003012 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713003013 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 945713003014 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713003015 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003016 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 945713003017 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 945713003018 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 945713003019 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003020 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713003021 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003022 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 945713003023 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 945713003024 active site 945713003025 dimer interface [polypeptide binding]; other site 945713003026 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 945713003027 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 945713003028 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003029 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 945713003030 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 945713003031 catalytic domain interface [polypeptide binding]; other site 945713003032 putative homodimer interface [polypeptide binding]; other site 945713003033 alpha-mannosidase; Provisional; Region: PRK09819 945713003034 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 945713003035 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 945713003036 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 945713003037 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 945713003038 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 945713003039 active site 945713003040 substrate binding site [chemical binding]; other site 945713003041 metal binding site [ion binding]; metal-binding site 945713003042 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 945713003043 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 945713003044 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 945713003045 putative active site cavity [active] 945713003046 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 945713003047 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 945713003048 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 945713003049 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 945713003050 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003051 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713003052 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 945713003053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003054 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713003055 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 945713003056 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 945713003057 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 945713003058 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 945713003059 putative metal binding site [ion binding]; other site 945713003060 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003061 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 945713003062 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 945713003063 putative metal binding site [ion binding]; other site 945713003064 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 945713003066 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 945713003067 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 945713003068 Na binding site [ion binding]; other site 945713003069 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 945713003070 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 945713003071 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 945713003072 active site 945713003073 trimer interface [polypeptide binding]; other site 945713003074 allosteric site; other site 945713003075 active site lid [active] 945713003076 hexamer (dimer of trimers) interface [polypeptide binding]; other site 945713003077 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713003078 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 945713003079 DXD motif; other site 945713003080 HEAT repeats; Region: HEAT_2; pfam13646 945713003081 Response regulator receiver domain; Region: Response_reg; pfam00072 945713003082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713003083 active site 945713003084 phosphorylation site [posttranslational modification] 945713003085 intermolecular recognition site; other site 945713003086 dimerization interface [polypeptide binding]; other site 945713003087 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 945713003088 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 945713003089 G1 box; other site 945713003090 putative GEF interaction site [polypeptide binding]; other site 945713003091 GTP/Mg2+ binding site [chemical binding]; other site 945713003092 Switch I region; other site 945713003093 G2 box; other site 945713003094 G3 box; other site 945713003095 Switch II region; other site 945713003096 G4 box; other site 945713003097 G5 box; other site 945713003098 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 945713003099 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 945713003100 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 945713003101 Enoylreductase; Region: PKS_ER; smart00829 945713003102 NAD(P) binding site [chemical binding]; other site 945713003103 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 945713003104 Formiminotransferase domain; Region: FTCD; pfam02971 945713003105 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 945713003106 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 945713003107 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 945713003108 putative active site; other site 945713003109 catalytic triad [active] 945713003110 putative dimer interface [polypeptide binding]; other site 945713003111 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 945713003112 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 945713003113 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003114 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003115 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 945713003116 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 945713003117 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 945713003118 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 945713003119 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945713003120 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713003121 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 945713003122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713003123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713003124 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 945713003125 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 945713003126 ligand binding site [chemical binding]; other site 945713003127 homodimer interface [polypeptide binding]; other site 945713003128 NAD(P) binding site [chemical binding]; other site 945713003129 trimer interface B [polypeptide binding]; other site 945713003130 trimer interface A [polypeptide binding]; other site 945713003131 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 945713003132 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 945713003133 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 945713003134 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 945713003135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 945713003136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 945713003137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 945713003138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713003139 nucleotide binding site [chemical binding]; other site 945713003140 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 945713003141 YacP-like NYN domain; Region: NYN_YacP; cl01491 945713003142 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 945713003143 active site 945713003144 Zn binding site [ion binding]; other site 945713003145 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 945713003146 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003147 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003148 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 945713003149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 945713003150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713003151 FeS/SAM binding site; other site 945713003152 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 945713003153 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 945713003154 RNA binding site [nucleotide binding]; other site 945713003155 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 945713003156 RNA binding site [nucleotide binding]; other site 945713003157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945713003158 RNA binding site [nucleotide binding]; other site 945713003159 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945713003160 RNA binding site [nucleotide binding]; other site 945713003161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945713003162 RNA binding site [nucleotide binding]; other site 945713003163 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 945713003164 RNA binding site [nucleotide binding]; other site 945713003165 cytidylate kinase; Provisional; Region: cmk; PRK00023 945713003166 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 945713003167 CMP-binding site; other site 945713003168 The sites determining sugar specificity; other site 945713003169 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 945713003170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713003171 Walker A motif; other site 945713003172 ATP binding site [chemical binding]; other site 945713003173 Walker B motif; other site 945713003174 arginine finger; other site 945713003175 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 945713003176 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 945713003177 GAF domain; Region: GAF_2; pfam13185 945713003178 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 945713003179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713003180 Walker A motif; other site 945713003181 ATP binding site [chemical binding]; other site 945713003182 Walker B motif; other site 945713003183 arginine finger; other site 945713003184 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 945713003185 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003186 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003187 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003188 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003189 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003190 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 945713003191 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003192 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945713003193 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 945713003194 active site 945713003195 dimerization interface [polypeptide binding]; other site 945713003196 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 945713003197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945713003198 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 945713003199 acyl-activating enzyme (AAE) consensus motif; other site 945713003200 putative AMP binding site [chemical binding]; other site 945713003201 putative active site [active] 945713003202 putative CoA binding site [chemical binding]; other site 945713003203 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 945713003204 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 945713003205 Glutamate binding site [chemical binding]; other site 945713003206 NAD binding site [chemical binding]; other site 945713003207 catalytic residues [active] 945713003208 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 945713003209 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 945713003210 CoA-ligase; Region: Ligase_CoA; pfam00549 945713003211 TPR repeat; Region: TPR_11; pfam13414 945713003212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003213 TPR motif; other site 945713003214 binding surface 945713003215 TPR repeat; Region: TPR_11; pfam13414 945713003216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003217 TPR motif; other site 945713003218 TPR repeat; Region: TPR_11; pfam13414 945713003219 binding surface 945713003220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003221 binding surface 945713003222 TPR motif; other site 945713003223 TPR repeat; Region: TPR_11; pfam13414 945713003224 TPR repeat; Region: TPR_11; pfam13414 945713003225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003226 binding surface 945713003227 TPR motif; other site 945713003228 TPR repeat; Region: TPR_11; pfam13414 945713003229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003230 binding surface 945713003231 TPR motif; other site 945713003232 TPR repeat; Region: TPR_11; pfam13414 945713003233 TPR repeat; Region: TPR_11; pfam13414 945713003234 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 945713003235 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 945713003236 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 945713003237 shikimate binding site; other site 945713003238 NAD(P) binding site [chemical binding]; other site 945713003239 aspartate aminotransferase; Provisional; Region: PRK05764 945713003240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713003241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713003242 homodimer interface [polypeptide binding]; other site 945713003243 catalytic residue [active] 945713003244 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 945713003245 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 945713003246 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 945713003247 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713003248 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003249 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 945713003250 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 945713003251 active site 945713003252 substrate-binding site [chemical binding]; other site 945713003253 metal-binding site [ion binding] 945713003254 ATP binding site [chemical binding]; other site 945713003255 aspartate aminotransferase; Provisional; Region: PRK05764 945713003256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713003257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713003258 homodimer interface [polypeptide binding]; other site 945713003259 catalytic residue [active] 945713003260 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 945713003261 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 945713003262 active site 945713003263 (T/H)XGH motif; other site 945713003264 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 945713003265 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 945713003266 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 945713003267 LVIVD repeat; Region: LVIVD; pfam08309 945713003268 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003269 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003270 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 945713003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713003272 S-adenosylmethionine binding site [chemical binding]; other site 945713003273 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 945713003274 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 945713003275 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 945713003276 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 945713003277 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 945713003278 HSP70 interaction site [polypeptide binding]; other site 945713003279 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 945713003280 substrate binding site [polypeptide binding]; other site 945713003281 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 945713003282 Zn binding sites [ion binding]; other site 945713003283 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 945713003284 dimer interface [polypeptide binding]; other site 945713003285 GrpE; Region: GrpE; pfam01025 945713003286 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 945713003287 dimer interface [polypeptide binding]; other site 945713003288 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 945713003289 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 945713003290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945713003291 MarR family; Region: MarR_2; pfam12802 945713003292 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 945713003293 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 945713003294 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 945713003295 Predicted transporter component [General function prediction only]; Region: COG2391 945713003296 Sulphur transport; Region: Sulf_transp; pfam04143 945713003297 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945713003298 active site residue [active] 945713003299 Transcriptional regulator; Region: Rrf2; pfam02082 945713003300 Rrf2 family protein; Region: rrf2_super; TIGR00738 945713003301 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 945713003302 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 945713003303 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 945713003304 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 945713003305 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 945713003306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945713003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713003308 Walker A/P-loop; other site 945713003309 ATP binding site [chemical binding]; other site 945713003310 Q-loop/lid; other site 945713003311 ABC transporter signature motif; other site 945713003312 Walker B; other site 945713003313 D-loop; other site 945713003314 H-loop/switch region; other site 945713003315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945713003316 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 945713003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713003318 Walker A/P-loop; other site 945713003319 ATP binding site [chemical binding]; other site 945713003320 Q-loop/lid; other site 945713003321 ABC transporter signature motif; other site 945713003322 Walker B; other site 945713003323 D-loop; other site 945713003324 H-loop/switch region; other site 945713003325 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 945713003326 MFS/sugar transport protein; Region: MFS_2; pfam13347 945713003327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713003328 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 945713003329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713003330 putative active site [active] 945713003331 heme pocket [chemical binding]; other site 945713003332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713003333 putative active site [active] 945713003334 heme pocket [chemical binding]; other site 945713003335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713003336 Walker A motif; other site 945713003337 ATP binding site [chemical binding]; other site 945713003338 Walker B motif; other site 945713003339 arginine finger; other site 945713003340 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713003341 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 945713003342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713003343 FeS/SAM binding site; other site 945713003344 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 945713003345 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 945713003346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713003347 FeS/SAM binding site; other site 945713003348 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 945713003349 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 945713003350 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 945713003351 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 945713003352 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 945713003353 CoenzymeA binding site [chemical binding]; other site 945713003354 subunit interaction site [polypeptide binding]; other site 945713003355 PHB binding site; other site 945713003356 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 945713003357 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713003358 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 945713003359 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713003360 N-terminal plug; other site 945713003361 ligand-binding site [chemical binding]; other site 945713003362 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713003363 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 945713003364 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713003365 N-terminal plug; other site 945713003366 ligand-binding site [chemical binding]; other site 945713003367 Sulphur transport; Region: Sulf_transp; pfam04143 945713003368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713003370 S-adenosylmethionine binding site [chemical binding]; other site 945713003371 GAF domain; Region: GAF; pfam01590 945713003372 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 945713003373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713003374 Walker A motif; other site 945713003375 ATP binding site [chemical binding]; other site 945713003376 Walker B motif; other site 945713003377 arginine finger; other site 945713003378 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 945713003379 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 945713003380 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 945713003381 dimerization interface [polypeptide binding]; other site 945713003382 DPS ferroxidase diiron center [ion binding]; other site 945713003383 ion pore; other site 945713003384 peroxiredoxin; Provisional; Region: PRK13189 945713003385 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 945713003386 dimer interface [polypeptide binding]; other site 945713003387 decamer (pentamer of dimers) interface [polypeptide binding]; other site 945713003388 catalytic triad [active] 945713003389 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 945713003390 Outer membrane efflux protein; Region: OEP; pfam02321 945713003391 Outer membrane efflux protein; Region: OEP; pfam02321 945713003392 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713003393 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713003394 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 945713003395 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 945713003396 active site 945713003397 FMN binding site [chemical binding]; other site 945713003398 substrate binding site [chemical binding]; other site 945713003399 putative catalytic residue [active] 945713003400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713003401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713003402 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 945713003403 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 945713003404 CoenzymeA binding site [chemical binding]; other site 945713003405 subunit interaction site [polypeptide binding]; other site 945713003406 PHB binding site; other site 945713003407 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 945713003408 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 945713003409 dimerization interface [polypeptide binding]; other site 945713003410 putative ATP binding site [chemical binding]; other site 945713003411 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 945713003412 active site 945713003413 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 945713003414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713003415 FeS/SAM binding site; other site 945713003416 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 945713003417 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 945713003418 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 945713003419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713003420 S-adenosylmethionine binding site [chemical binding]; other site 945713003421 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 945713003422 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 945713003423 active site 945713003424 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 945713003425 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 945713003426 ATP binding site [chemical binding]; other site 945713003427 Mg++ binding site [ion binding]; other site 945713003428 motif III; other site 945713003429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713003430 nucleotide binding region [chemical binding]; other site 945713003431 ATP-binding site [chemical binding]; other site 945713003432 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 945713003433 RNA binding site [nucleotide binding]; other site 945713003434 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003435 BNR repeat-like domain; Region: BNR_2; pfam13088 945713003436 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 945713003437 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003438 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 945713003439 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 945713003440 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 945713003441 active site 945713003442 substrate-binding site [chemical binding]; other site 945713003443 metal-binding site [ion binding] 945713003444 ATP binding site [chemical binding]; other site 945713003445 acetyl-CoA synthetase; Provisional; Region: PRK00174 945713003446 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 945713003447 active site 945713003448 CoA binding site [chemical binding]; other site 945713003449 acyl-activating enzyme (AAE) consensus motif; other site 945713003450 AMP binding site [chemical binding]; other site 945713003451 acetate binding site [chemical binding]; other site 945713003452 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 945713003453 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 945713003454 active site 945713003455 nucleophile elbow; other site 945713003456 citrate lyase, alpha subunit; Region: citF; TIGR01584 945713003457 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 945713003458 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 945713003459 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 945713003460 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 945713003461 homoaconitase; Region: h_aconitase; TIGR00139 945713003462 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 945713003463 substrate binding site [chemical binding]; other site 945713003464 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 945713003465 ligand binding site [chemical binding]; other site 945713003466 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 945713003467 substrate binding site [chemical binding]; other site 945713003468 HD domain; Region: HD; pfam01966 945713003469 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 945713003470 Carbon starvation protein CstA; Region: CstA; pfam02554 945713003471 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 945713003472 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 945713003473 tartrate dehydrogenase; Region: TTC; TIGR02089 945713003474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713003475 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713003476 putative active site [active] 945713003477 heme pocket [chemical binding]; other site 945713003478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713003479 putative active site [active] 945713003480 heme pocket [chemical binding]; other site 945713003481 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 945713003482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713003483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713003484 dimer interface [polypeptide binding]; other site 945713003485 phosphorylation site [posttranslational modification] 945713003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713003487 ATP binding site [chemical binding]; other site 945713003488 Mg2+ binding site [ion binding]; other site 945713003489 G-X-G motif; other site 945713003490 Response regulator receiver domain; Region: Response_reg; pfam00072 945713003491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713003492 active site 945713003493 phosphorylation site [posttranslational modification] 945713003494 intermolecular recognition site; other site 945713003495 dimerization interface [polypeptide binding]; other site 945713003496 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 945713003497 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 945713003498 DNA methylase; Region: N6_N4_Mtase; cl17433 945713003499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945713003500 catalytic core [active] 945713003501 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 945713003502 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945713003503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 945713003504 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 945713003505 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 945713003506 GIY-YIG motif/motif A; other site 945713003507 active site 945713003508 catalytic site [active] 945713003509 putative DNA binding site [nucleotide binding]; other site 945713003510 metal binding site [ion binding]; metal-binding site 945713003511 UvrB/uvrC motif; Region: UVR; pfam02151 945713003512 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 945713003513 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 945713003514 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 945713003515 ligand binding site; other site 945713003516 oligomer interface; other site 945713003517 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 945713003518 dimer interface [polypeptide binding]; other site 945713003519 N-terminal domain interface [polypeptide binding]; other site 945713003520 sulfate 1 binding site; other site 945713003521 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 945713003522 Zn binding site [ion binding]; other site 945713003523 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 945713003524 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713003525 putative active site [active] 945713003526 putative metal binding site [ion binding]; other site 945713003527 Transglycosylase; Region: Transgly; pfam00912 945713003528 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 945713003529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 945713003530 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713003531 GIY-YIG motif/motif A; other site 945713003532 putative active site [active] 945713003533 putative metal binding site [ion binding]; other site 945713003534 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 945713003535 GIY-YIG motif/motif A; other site 945713003536 active site 945713003537 catalytic site [active] 945713003538 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 945713003539 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713003540 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 945713003541 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003542 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003543 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 945713003544 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 945713003545 Zonular occludens toxin (Zot); Region: Zot; cl17485 945713003546 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 945713003547 Transcriptional regulators [Transcription]; Region: PurR; COG1609 945713003548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 945713003549 DNA binding site [nucleotide binding] 945713003550 domain linker motif; other site 945713003551 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 945713003552 dimerization interface [polypeptide binding]; other site 945713003553 ligand binding site [chemical binding]; other site 945713003554 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 945713003555 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 945713003556 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 945713003557 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 945713003558 putative ligand binding site [chemical binding]; other site 945713003559 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 945713003560 putative ligand binding site [chemical binding]; other site 945713003561 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003562 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713003563 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713003564 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 945713003566 Putative glucoamylase; Region: Glycoamylase; pfam10091 945713003567 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 945713003568 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 945713003569 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 945713003570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713003571 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 945713003572 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 945713003573 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 945713003574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 945713003575 Putative glucoamylase; Region: Glycoamylase; pfam10091 945713003576 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003577 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 945713003578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 945713003579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713003580 putative PBP binding loops; other site 945713003581 ABC-ATPase subunit interface; other site 945713003582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 945713003583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713003584 dimer interface [polypeptide binding]; other site 945713003585 conserved gate region; other site 945713003586 putative PBP binding loops; other site 945713003587 ABC-ATPase subunit interface; other site 945713003588 SurA N-terminal domain; Region: SurA_N_3; cl07813 945713003589 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 945713003590 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 945713003591 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 945713003592 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 945713003593 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 945713003594 Walker A/P-loop; other site 945713003595 ATP binding site [chemical binding]; other site 945713003596 Q-loop/lid; other site 945713003597 ABC transporter signature motif; other site 945713003598 Walker B; other site 945713003599 D-loop; other site 945713003600 H-loop/switch region; other site 945713003601 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 945713003602 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 945713003603 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 945713003604 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 945713003605 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 945713003606 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 945713003607 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 945713003608 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 945713003609 Transposase IS200 like; Region: Y1_Tnp; cl00848 945713003610 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 945713003611 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 945713003612 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 945713003613 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 945713003614 Transposase IS200 like; Region: Y1_Tnp; cl00848 945713003615 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 945713003616 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 945713003617 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 945713003618 TPR repeat; Region: TPR_11; pfam13414 945713003619 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 945713003620 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945713003621 active site 945713003622 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 945713003623 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 945713003624 putative active site [active] 945713003625 putative dimer interface [polypeptide binding]; other site 945713003626 DNA protecting protein DprA; Region: dprA; TIGR00732 945713003627 Fic family protein [Function unknown]; Region: COG3177 945713003628 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 945713003629 Fic/DOC family; Region: Fic; pfam02661 945713003630 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 945713003631 Protein of unknown function (DUF499); Region: DUF499; pfam04465 945713003632 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 945713003633 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 945713003634 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 945713003635 Methyltransferase domain; Region: Methyltransf_26; pfam13659 945713003636 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 945713003637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713003638 ATP binding site [chemical binding]; other site 945713003639 putative Mg++ binding site [ion binding]; other site 945713003640 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 945713003641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713003642 nucleotide binding region [chemical binding]; other site 945713003643 ATP-binding site [chemical binding]; other site 945713003644 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 945713003645 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713003646 anti sigma factor interaction site; other site 945713003647 regulatory phosphorylation site [posttranslational modification]; other site 945713003648 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 945713003649 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 945713003650 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 945713003651 TPP-binding site [chemical binding]; other site 945713003652 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 945713003653 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 945713003654 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 945713003655 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 945713003656 VPS10 domain; Region: VPS10; smart00602 945713003657 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003658 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 945713003659 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 945713003660 Transposase IS200 like; Region: Y1_Tnp; pfam01797 945713003661 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 945713003662 hypothetical protein; Reviewed; Region: PRK09588 945713003663 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 945713003664 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 945713003665 NodB motif; other site 945713003666 putative active site [active] 945713003667 putative catalytic site [active] 945713003668 putative Zn binding site [ion binding]; other site 945713003669 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713003670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713003671 active site 945713003672 Radical SAM superfamily; Region: Radical_SAM; pfam04055 945713003673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713003674 FeS/SAM binding site; other site 945713003675 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 945713003676 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 945713003677 Peptidase family M50; Region: Peptidase_M50; pfam02163 945713003678 active site 945713003679 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 945713003680 putative substrate binding region [chemical binding]; other site 945713003681 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713003682 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 945713003683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713003684 S-adenosylmethionine binding site [chemical binding]; other site 945713003685 BNR repeat-like domain; Region: BNR_3; pfam13859 945713003686 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713003688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713003689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 945713003690 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713003691 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 945713003692 putative metal binding site; other site 945713003693 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713003694 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713003695 putative active site [active] 945713003696 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 945713003697 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 945713003698 Ferritin-like domain; Region: Ferritin; pfam00210 945713003699 ferroxidase diiron center [ion binding]; other site 945713003700 cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434 945713003701 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 945713003702 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 945713003703 Phosphoglycerate kinase; Region: PGK; pfam00162 945713003704 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 945713003705 substrate binding site [chemical binding]; other site 945713003706 hinge regions; other site 945713003707 ADP binding site [chemical binding]; other site 945713003708 catalytic site [active] 945713003709 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 945713003710 DEAD-like helicases superfamily; Region: DEXDc; smart00487 945713003711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713003712 ATP binding site [chemical binding]; other site 945713003713 putative Mg++ binding site [ion binding]; other site 945713003714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713003715 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 945713003716 nucleotide binding region [chemical binding]; other site 945713003717 ATP-binding site [chemical binding]; other site 945713003718 HRDC domain; Region: HRDC; pfam00570 945713003719 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713003720 VPS10 domain; Region: VPS10; smart00602 945713003721 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 945713003722 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 945713003723 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 945713003724 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 945713003725 propionate/acetate kinase; Provisional; Region: PRK12379 945713003726 short chain dehydrogenase; Provisional; Region: PRK08339 945713003727 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 945713003728 putative NAD(P) binding site [chemical binding]; other site 945713003729 putative active site [active] 945713003730 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 945713003731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713003732 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 945713003733 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003734 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945713003735 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713003736 active site 945713003737 catalytic site [active] 945713003738 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 945713003739 carboxylate-amine ligase; Provisional; Region: PRK13515 945713003740 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 945713003741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713003742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 945713003743 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 945713003744 MutS domain I; Region: MutS_I; pfam01624 945713003745 MutS domain II; Region: MutS_II; pfam05188 945713003746 MutS domain III; Region: MutS_III; pfam05192 945713003747 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 945713003748 Walker A/P-loop; other site 945713003749 ATP binding site [chemical binding]; other site 945713003750 Q-loop/lid; other site 945713003751 ABC transporter signature motif; other site 945713003752 Walker B; other site 945713003753 D-loop; other site 945713003754 H-loop/switch region; other site 945713003755 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 945713003756 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 945713003757 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 945713003758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 945713003759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 945713003760 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 945713003761 active site 945713003762 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 945713003763 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003764 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003765 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 945713003766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713003767 Interdomain contacts; other site 945713003768 Cytokine receptor motif; other site 945713003769 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003770 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 945713003771 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 945713003772 active site 945713003773 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713003774 Interdomain contacts; other site 945713003775 Cytokine receptor motif; other site 945713003776 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 945713003777 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 945713003778 active site 945713003779 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 945713003780 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 945713003781 active site 945713003782 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 945713003783 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 945713003784 putative active site [active] 945713003785 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003786 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713003787 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713003788 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003789 Peptidase family M23; Region: Peptidase_M23; pfam01551 945713003790 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713003791 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 945713003792 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 945713003793 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 945713003794 heme-binding residues [chemical binding]; other site 945713003795 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 945713003796 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 945713003797 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 945713003798 Cytochrome c; Region: Cytochrom_C; pfam00034 945713003799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713003800 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713003801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713003802 active site 945713003803 phosphorylation site [posttranslational modification] 945713003804 intermolecular recognition site; other site 945713003805 dimerization interface [polypeptide binding]; other site 945713003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713003807 Walker A motif; other site 945713003808 ATP binding site [chemical binding]; other site 945713003809 Walker B motif; other site 945713003810 arginine finger; other site 945713003811 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713003812 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 945713003813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713003814 putative active site [active] 945713003815 heme pocket [chemical binding]; other site 945713003816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713003817 dimer interface [polypeptide binding]; other site 945713003818 phosphorylation site [posttranslational modification] 945713003819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713003820 ATP binding site [chemical binding]; other site 945713003821 Mg2+ binding site [ion binding]; other site 945713003822 G-X-G motif; other site 945713003823 C-N hydrolase family amidase; Provisional; Region: PRK10438 945713003824 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 945713003825 active site 945713003826 catalytic triad [active] 945713003827 dimer interface [polypeptide binding]; other site 945713003828 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 945713003830 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945713003831 active site 945713003832 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 945713003833 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 945713003834 acyl-activating enzyme (AAE) consensus motif; other site 945713003835 putative AMP binding site [chemical binding]; other site 945713003836 putative active site [active] 945713003837 putative CoA binding site [chemical binding]; other site 945713003838 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 945713003839 UbiA prenyltransferase family; Region: UbiA; pfam01040 945713003840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945713003841 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 945713003842 substrate binding site [chemical binding]; other site 945713003843 oxyanion hole (OAH) forming residues; other site 945713003844 trimer interface [polypeptide binding]; other site 945713003845 PGAP1-like protein; Region: PGAP1; pfam07819 945713003846 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 945713003847 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 945713003848 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 945713003849 dimer interface [polypeptide binding]; other site 945713003850 tetramer interface [polypeptide binding]; other site 945713003851 PYR/PP interface [polypeptide binding]; other site 945713003852 TPP binding site [chemical binding]; other site 945713003853 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 945713003854 TPP-binding site; other site 945713003855 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 945713003856 chorismate binding enzyme; Region: Chorismate_bind; cl10555 945713003857 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 945713003858 ribosome small subunit-dependent GTPase A; Region: TIGR00157 945713003859 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 945713003860 GTPase/Zn-binding domain interface [polypeptide binding]; other site 945713003861 GTP/Mg2+ binding site [chemical binding]; other site 945713003862 G4 box; other site 945713003863 G5 box; other site 945713003864 G1 box; other site 945713003865 Switch I region; other site 945713003866 G2 box; other site 945713003867 G3 box; other site 945713003868 Switch II region; other site 945713003869 Transposase domain (DUF772); Region: DUF772; pfam05598 945713003870 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713003871 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713003872 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713003873 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 945713003874 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 945713003875 ATP binding site [chemical binding]; other site 945713003876 active site 945713003877 substrate binding site [chemical binding]; other site 945713003878 Protein of unknown function (DUF971); Region: DUF971; pfam06155 945713003879 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 945713003880 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 945713003881 tetramer interfaces [polypeptide binding]; other site 945713003882 binuclear metal-binding site [ion binding]; other site 945713003883 competence damage-inducible protein A; Provisional; Region: PRK00549 945713003884 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 945713003885 putative MPT binding site; other site 945713003886 Competence-damaged protein; Region: CinA; pfam02464 945713003887 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 945713003888 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 945713003889 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 945713003890 recombinase A; Provisional; Region: recA; PRK09354 945713003891 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 945713003892 hexamer interface [polypeptide binding]; other site 945713003893 Walker A motif; other site 945713003894 ATP binding site [chemical binding]; other site 945713003895 Walker B motif; other site 945713003896 recombination regulator RecX; Reviewed; Region: recX; PRK00117 945713003897 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 945713003898 nudix motif; other site 945713003899 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 945713003900 FAD binding domain; Region: FAD_binding_4; pfam01565 945713003901 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 945713003902 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 945713003903 cofactor binding site; other site 945713003904 metal binding site [ion binding]; metal-binding site 945713003905 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 945713003906 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Bcp; COG1225 945713003907 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 945713003908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713003909 catalytic triad [active] 945713003910 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 945713003911 active site 945713003912 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 945713003913 homodecamer interface [polypeptide binding]; other site 945713003914 GTP cyclohydrolase I; Provisional; Region: PLN03044 945713003915 active site 945713003916 putative catalytic site residues [active] 945713003917 zinc binding site [ion binding]; other site 945713003918 GTP-CH-I/GFRP interaction surface; other site 945713003919 classical (c) SDRs; Region: SDR_c; cd05233 945713003920 NAD(P) binding site [chemical binding]; other site 945713003921 active site 945713003922 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 945713003923 dimer interface [polypeptide binding]; other site 945713003924 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 945713003925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713003926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713003927 DNA binding residues [nucleotide binding] 945713003928 TPR repeat; Region: TPR_11; pfam13414 945713003929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003930 binding surface 945713003931 TPR motif; other site 945713003932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713003933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713003934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003935 binding surface 945713003936 TPR motif; other site 945713003937 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 945713003938 integron integrase; Region: integrase_gron; TIGR02249 945713003939 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 945713003940 Int/Topo IB signature motif; other site 945713003941 Family description; Region: VCBS; pfam13517 945713003942 Family description; Region: VCBS; pfam13517 945713003943 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713003944 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713003945 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 945713003946 Protein of unknown function DUF262; Region: DUF262; pfam03235 945713003947 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945713003948 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 945713003949 active site 945713003950 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003952 binding surface 945713003953 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713003954 TPR motif; other site 945713003955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003956 binding surface 945713003957 TPR motif; other site 945713003958 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713003959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003960 binding surface 945713003961 TPR motif; other site 945713003962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003963 binding surface 945713003964 TPR motif; other site 945713003965 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 945713003966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003967 binding surface 945713003968 TPR motif; other site 945713003969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713003970 binding surface 945713003971 TPR motif; other site 945713003972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713003973 binding surface 945713003974 TPR motif; other site 945713003975 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713003976 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713003977 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 945713003978 Sporulation related domain; Region: SPOR; pfam05036 945713003979 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 945713003980 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 945713003981 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 945713003982 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 945713003983 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 945713003984 NHL repeat; Region: NHL; pfam01436 945713003985 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 945713003986 dimer interface [polypeptide binding]; other site 945713003987 [2Fe-2S] cluster binding site [ion binding]; other site 945713003988 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 945713003989 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 945713003990 minor groove reading motif; other site 945713003991 helix-hairpin-helix signature motif; other site 945713003992 substrate binding pocket [chemical binding]; other site 945713003993 active site 945713003994 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 945713003995 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 945713003996 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 945713003997 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 945713003998 catalytic triad [active] 945713003999 Propeptide_C25; Region: Propeptide_C25; pfam08126 945713004000 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 945713004001 active site 945713004002 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713004003 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 945713004004 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 945713004005 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004006 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 945713004007 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 945713004008 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713004009 GTP-binding protein Der; Reviewed; Region: PRK00093 945713004010 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 945713004011 G1 box; other site 945713004012 GTP/Mg2+ binding site [chemical binding]; other site 945713004013 Switch I region; other site 945713004014 G2 box; other site 945713004015 Switch II region; other site 945713004016 G3 box; other site 945713004017 G4 box; other site 945713004018 G5 box; other site 945713004019 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 945713004020 G1 box; other site 945713004021 GTP/Mg2+ binding site [chemical binding]; other site 945713004022 Switch I region; other site 945713004023 G2 box; other site 945713004024 G3 box; other site 945713004025 Switch II region; other site 945713004026 G4 box; other site 945713004027 G5 box; other site 945713004028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713004029 active site 945713004030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713004031 binding surface 945713004032 TPR motif; other site 945713004033 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713004034 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 945713004035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713004036 Zn2+ binding site [ion binding]; other site 945713004037 Mg2+ binding site [ion binding]; other site 945713004038 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 945713004039 synthetase active site [active] 945713004040 NTP binding site [chemical binding]; other site 945713004041 metal binding site [ion binding]; metal-binding site 945713004042 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 945713004043 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 945713004044 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 945713004045 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 945713004046 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 945713004047 Hexamer interface [polypeptide binding]; other site 945713004048 Hexagonal pore residue; other site 945713004049 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 945713004050 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 945713004051 Hexamer interface [polypeptide binding]; other site 945713004052 Hexagonal pore residue; other site 945713004053 thymidylate kinase; Validated; Region: tmk; PRK00698 945713004054 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 945713004055 TMP-binding site; other site 945713004056 ATP-binding site [chemical binding]; other site 945713004057 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 945713004058 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 945713004059 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 945713004060 protein binding site [polypeptide binding]; other site 945713004061 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 945713004062 Catalytic dyad [active] 945713004063 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 945713004064 heme-binding residues [chemical binding]; other site 945713004065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 945713004066 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 945713004067 molybdopterin cofactor binding site; other site 945713004068 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 945713004069 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 945713004070 4Fe-4S binding domain; Region: Fer4; cl02805 945713004071 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 945713004072 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 945713004073 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 945713004074 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 945713004075 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 945713004076 cytochrome c-550; Provisional; Region: psbV; cl17239 945713004077 Cytochrome c; Region: Cytochrom_C; pfam00034 945713004078 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 945713004079 Cu(I) binding site [ion binding]; other site 945713004080 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 945713004081 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 945713004082 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 945713004083 Subunit I/III interface [polypeptide binding]; other site 945713004084 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 945713004085 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 945713004086 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 945713004087 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 945713004088 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 945713004089 UbiA prenyltransferase family; Region: UbiA; pfam01040 945713004090 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 945713004091 Cytochrome c; Region: Cytochrom_C; cl11414 945713004092 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713004093 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 945713004094 putative active site [active] 945713004095 putative CoA binding site [chemical binding]; other site 945713004096 nudix motif; other site 945713004097 metal binding site [ion binding]; metal-binding site 945713004098 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 945713004099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713004100 motif II; other site 945713004101 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713004102 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 945713004103 NAD binding site [chemical binding]; other site 945713004104 putative substrate binding site 2 [chemical binding]; other site 945713004105 putative substrate binding site 1 [chemical binding]; other site 945713004106 active site 945713004107 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 945713004108 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 945713004109 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 945713004110 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 945713004111 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 945713004112 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713004113 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713004114 ligand binding site [chemical binding]; other site 945713004115 Sporulation related domain; Region: SPOR; pfam05036 945713004116 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 945713004117 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 945713004118 Mg++ binding site [ion binding]; other site 945713004119 putative catalytic motif [active] 945713004120 substrate binding site [chemical binding]; other site 945713004121 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713004122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713004123 active site 945713004124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713004125 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713004126 GIY-YIG motif/motif A; other site 945713004127 putative active site [active] 945713004128 putative metal binding site [ion binding]; other site 945713004129 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713004130 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 945713004131 putative metal binding site; other site 945713004132 putative acyl transferase; Provisional; Region: PRK10502 945713004133 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 945713004134 putative trimer interface [polypeptide binding]; other site 945713004135 putative active site [active] 945713004136 putative substrate binding site [chemical binding]; other site 945713004137 putative CoA binding site [chemical binding]; other site 945713004138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713004139 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 945713004140 putative ADP-binding pocket [chemical binding]; other site 945713004141 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945713004142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713004143 O-Antigen ligase; Region: Wzy_C; pfam04932 945713004144 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 945713004145 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 945713004146 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945713004147 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 945713004148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713004149 Transposase; Region: HTH_Tnp_1; pfam01527 945713004150 putative transposase OrfB; Reviewed; Region: PHA02517 945713004151 Homeodomain-like domain; Region: HTH_32; pfam13565 945713004152 Integrase core domain; Region: rve; pfam00665 945713004153 Integrase core domain; Region: rve_3; pfam13683 945713004154 chain length determinant protein EpsF; Region: EpsF; TIGR03017 945713004155 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 945713004156 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 945713004157 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 945713004158 SLBB domain; Region: SLBB; pfam10531 945713004159 SLBB domain; Region: SLBB; pfam10531 945713004160 SLBB domain; Region: SLBB; pfam10531 945713004161 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 945713004162 SLBB domain; Region: SLBB; pfam10531 945713004163 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 945713004164 SLBB domain; Region: SLBB; pfam10531 945713004165 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 945713004166 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 945713004167 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 945713004168 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 945713004169 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 945713004170 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713004171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713004172 homodimer interface [polypeptide binding]; other site 945713004173 catalytic residue [active] 945713004174 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 945713004175 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 945713004176 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945713004177 carboxyltransferase (CT) interaction site; other site 945713004178 biotinylation site [posttranslational modification]; other site 945713004179 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 945713004180 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945713004181 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945713004182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713004183 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 945713004184 dimer interface [polypeptide binding]; other site 945713004185 substrate binding site [chemical binding]; other site 945713004186 metal binding site [ion binding]; metal-binding site 945713004187 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 945713004188 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 945713004189 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 945713004190 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 945713004191 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 945713004192 active site 945713004193 dimer interface [polypeptide binding]; other site 945713004194 motif 1; other site 945713004195 motif 2; other site 945713004196 motif 3; other site 945713004197 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 945713004198 anticodon binding site; other site 945713004199 translation initiation factor IF-3; Region: infC; TIGR00168 945713004200 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 945713004201 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 945713004202 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 945713004203 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 945713004204 23S rRNA binding site [nucleotide binding]; other site 945713004205 L21 binding site [polypeptide binding]; other site 945713004206 L13 binding site [polypeptide binding]; other site 945713004207 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 945713004208 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 945713004209 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 945713004210 dimer interface [polypeptide binding]; other site 945713004211 motif 1; other site 945713004212 active site 945713004213 motif 2; other site 945713004214 motif 3; other site 945713004215 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 945713004216 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 945713004217 putative tRNA-binding site [nucleotide binding]; other site 945713004218 B3/4 domain; Region: B3_4; pfam03483 945713004219 tRNA synthetase B5 domain; Region: B5; pfam03484 945713004220 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 945713004221 dimer interface [polypeptide binding]; other site 945713004222 motif 1; other site 945713004223 motif 3; other site 945713004224 motif 2; other site 945713004225 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 945713004226 Cell division protein ZapA; Region: ZapA; pfam05164 945713004227 phosphodiesterase; Provisional; Region: PRK12704 945713004228 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 945713004229 KH domain; Region: KH_1; pfam00013 945713004230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713004231 Zn2+ binding site [ion binding]; other site 945713004232 Mg2+ binding site [ion binding]; other site 945713004233 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 945713004234 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 945713004235 CoA-binding site [chemical binding]; other site 945713004236 Proline dehydrogenase; Region: Pro_dh; cl03282 945713004237 UGMP family protein; Validated; Region: PRK09604 945713004238 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 945713004239 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 945713004240 YceG-like family; Region: YceG; pfam02618 945713004241 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 945713004242 dimerization interface [polypeptide binding]; other site 945713004243 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713004244 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713004245 imidazolonepropionase; Validated; Region: PRK09356 945713004246 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 945713004247 active site 945713004248 Sporulation related domain; Region: SPOR; pfam05036 945713004249 glycogen synthase; Provisional; Region: glgA; PRK00654 945713004250 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 945713004251 ADP-binding pocket [chemical binding]; other site 945713004252 homodimer interface [polypeptide binding]; other site 945713004253 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 945713004254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713004255 active site 945713004256 motif I; other site 945713004257 motif II; other site 945713004258 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 945713004259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713004260 TPR motif; other site 945713004261 TPR repeat; Region: TPR_11; pfam13414 945713004262 binding surface 945713004263 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 945713004264 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 945713004265 dimer interface [polypeptide binding]; other site 945713004266 active site 945713004267 glycine-pyridoxal phosphate binding site [chemical binding]; other site 945713004268 folate binding site [chemical binding]; other site 945713004269 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 945713004270 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 945713004271 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 945713004272 substrate binding pocket [chemical binding]; other site 945713004273 chain length determination region; other site 945713004274 substrate-Mg2+ binding site; other site 945713004275 catalytic residues [active] 945713004276 aspartate-rich region 1; other site 945713004277 active site lid residues [active] 945713004278 aspartate-rich region 2; other site 945713004279 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945713004280 Ligand Binding Site [chemical binding]; other site 945713004281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713004282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713004283 ligand binding site [chemical binding]; other site 945713004284 flexible hinge region; other site 945713004285 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 945713004286 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 945713004287 catalytic residues [active] 945713004288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 945713004289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 945713004290 active site 945713004291 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 945713004292 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 945713004293 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 945713004294 4Fe-4S binding domain; Region: Fer4; cl02805 945713004295 Cysteine-rich domain; Region: CCG; pfam02754 945713004296 Cysteine-rich domain; Region: CCG; pfam02754 945713004297 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 945713004298 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 945713004299 putative active site [active] 945713004300 putative metal binding site [ion binding]; other site 945713004301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713004302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713004303 putative substrate translocation pore; other site 945713004304 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 945713004305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 945713004306 FMN binding site [chemical binding]; other site 945713004307 active site 945713004308 catalytic residues [active] 945713004309 substrate binding site [chemical binding]; other site 945713004310 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 945713004311 hypothetical protein; Provisional; Region: PRK08609 945713004312 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 945713004313 metal binding triad [ion binding]; metal-binding site 945713004314 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 945713004315 active site 945713004316 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 945713004317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945713004318 substrate binding site [chemical binding]; other site 945713004319 oxyanion hole (OAH) forming residues; other site 945713004320 trimer interface [polypeptide binding]; other site 945713004321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713004322 active site 945713004323 Predicted methyltransferases [General function prediction only]; Region: COG0313 945713004324 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 945713004325 putative SAM binding site [chemical binding]; other site 945713004326 putative homodimer interface [polypeptide binding]; other site 945713004327 L-lysine aminotransferase; Provisional; Region: PRK08297 945713004328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945713004329 inhibitor-cofactor binding pocket; inhibition site 945713004330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713004331 catalytic residue [active] 945713004332 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945713004333 active site 945713004334 catalytic residues [active] 945713004335 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713004336 Interdomain contacts; other site 945713004337 Cytokine receptor motif; other site 945713004338 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004339 aldehyde dehydrogenase family 7 member; Region: PLN02315 945713004340 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 945713004341 tetrameric interface [polypeptide binding]; other site 945713004342 NAD binding site [chemical binding]; other site 945713004343 catalytic residues [active] 945713004344 carboxy-terminal protease; Provisional; Region: PRK11186 945713004345 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 945713004346 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 945713004347 protein binding site [polypeptide binding]; other site 945713004348 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 945713004349 Catalytic dyad [active] 945713004350 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 945713004351 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 945713004352 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713004353 catalytic triad [active] 945713004354 adenylosuccinate lyase; Provisional; Region: PRK07492 945713004355 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 945713004356 tetramer interface [polypeptide binding]; other site 945713004357 active site 945713004358 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 945713004359 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713004360 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945713004361 protein binding site [polypeptide binding]; other site 945713004362 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 945713004363 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713004364 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 945713004365 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004366 hypothetical protein; Provisional; Region: PRK04164 945713004367 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 945713004368 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 945713004369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713004370 S-adenosylmethionine binding site [chemical binding]; other site 945713004371 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 945713004372 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 945713004373 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 945713004374 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 945713004375 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713004376 four helix bundle protein; Region: TIGR02436 945713004377 peptide chain release factor 2; Validated; Region: prfB; PRK00578 945713004378 This domain is found in peptide chain release factors; Region: PCRF; smart00937 945713004379 RF-1 domain; Region: RF-1; pfam00472 945713004380 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 945713004381 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 945713004382 DNA binding site [nucleotide binding] 945713004383 active site 945713004384 PspC domain; Region: PspC; pfam04024 945713004385 NAD synthetase; Provisional; Region: PRK13981 945713004386 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 945713004387 multimer interface [polypeptide binding]; other site 945713004388 active site 945713004389 catalytic triad [active] 945713004390 protein interface 1 [polypeptide binding]; other site 945713004391 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 945713004392 homodimer interface [polypeptide binding]; other site 945713004393 NAD binding pocket [chemical binding]; other site 945713004394 ATP binding pocket [chemical binding]; other site 945713004395 Mg binding site [ion binding]; other site 945713004396 active-site loop [active] 945713004397 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 945713004398 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 945713004399 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 945713004400 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713004401 DsbD alpha interface [polypeptide binding]; other site 945713004402 catalytic residues [active] 945713004403 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 945713004404 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 945713004405 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 945713004406 dimer interface [polypeptide binding]; other site 945713004407 PYR/PP interface [polypeptide binding]; other site 945713004408 TPP binding site [chemical binding]; other site 945713004409 substrate binding site [chemical binding]; other site 945713004410 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 945713004411 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 945713004412 TPP-binding site [chemical binding]; other site 945713004413 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 945713004414 DHH family; Region: DHH; pfam01368 945713004415 DHHA1 domain; Region: DHHA1; pfam02272 945713004416 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 945713004417 multifunctional aminopeptidase A; Provisional; Region: PRK00913 945713004418 interface (dimer of trimers) [polypeptide binding]; other site 945713004419 Substrate-binding/catalytic site; other site 945713004420 Zn-binding sites [ion binding]; other site 945713004421 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713004422 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945713004423 Walker A/P-loop; other site 945713004424 ATP binding site [chemical binding]; other site 945713004425 Q-loop/lid; other site 945713004426 ABC transporter signature motif; other site 945713004427 Walker B; other site 945713004428 D-loop; other site 945713004429 H-loop/switch region; other site 945713004430 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 945713004431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713004432 FtsX-like permease family; Region: FtsX; pfam02687 945713004433 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 945713004434 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713004435 FtsX-like permease family; Region: FtsX; pfam02687 945713004436 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713004437 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004438 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713004439 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 945713004440 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713004441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713004442 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004443 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713004444 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 945713004445 PA/protease or protease-like domain interface [polypeptide binding]; other site 945713004446 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713004447 Peptidase family M28; Region: Peptidase_M28; pfam04389 945713004448 metal binding site [ion binding]; metal-binding site 945713004449 PBP superfamily domain; Region: PBP_like_2; cl17296 945713004450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713004451 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 945713004452 putative active site [active] 945713004453 putative metal binding site [ion binding]; other site 945713004454 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 945713004455 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 945713004456 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945713004457 putative acyl-acceptor binding pocket; other site 945713004458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 945713004459 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 945713004460 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 945713004461 NeuB family; Region: NeuB; pfam03102 945713004462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 945713004463 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 945713004464 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 945713004465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713004466 NAD(P) binding site [chemical binding]; other site 945713004467 active site 945713004468 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 945713004469 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945713004470 inhibitor-cofactor binding pocket; inhibition site 945713004471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713004472 catalytic residue [active] 945713004473 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 945713004474 ligand binding site; other site 945713004475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713004476 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 945713004477 dimer interface [polypeptide binding]; other site 945713004478 catalytic triad [active] 945713004479 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 945713004480 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 945713004481 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 945713004482 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 945713004483 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 945713004484 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713004485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713004486 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713004487 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713004488 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713004489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713004490 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713004491 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713004492 putative active site [active] 945713004493 DNA polymerase I; Provisional; Region: PRK05755 945713004494 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 945713004495 active site 945713004496 metal binding site 1 [ion binding]; metal-binding site 945713004497 putative 5' ssDNA interaction site; other site 945713004498 metal binding site 3; metal-binding site 945713004499 metal binding site 2 [ion binding]; metal-binding site 945713004500 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 945713004501 putative DNA binding site [nucleotide binding]; other site 945713004502 putative metal binding site [ion binding]; other site 945713004503 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 945713004504 active site 945713004505 catalytic site [active] 945713004506 substrate binding site [chemical binding]; other site 945713004507 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 945713004508 active site 945713004509 DNA binding site [nucleotide binding] 945713004510 catalytic site [active] 945713004511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 945713004512 K+ potassium transporter; Region: K_trans; pfam02705 945713004513 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 945713004514 putative catalytic site [active] 945713004515 putative metal binding site [ion binding]; other site 945713004516 putative phosphate binding site [ion binding]; other site 945713004517 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 945713004518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713004519 NAD(P) binding site [chemical binding]; other site 945713004520 active site 945713004521 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 945713004522 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 945713004523 Yqey-like protein; Region: YqeY; pfam09424 945713004524 Colicin V production protein; Region: Colicin_V; pfam02674 945713004525 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 945713004526 MutS domain III; Region: MutS_III; pfam05192 945713004527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713004528 Walker A/P-loop; other site 945713004529 ATP binding site [chemical binding]; other site 945713004530 Q-loop/lid; other site 945713004531 ABC transporter signature motif; other site 945713004532 Walker B; other site 945713004533 D-loop; other site 945713004534 H-loop/switch region; other site 945713004535 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 945713004536 homodimer interface [polypeptide binding]; other site 945713004537 Smr domain; Region: Smr; pfam01713 945713004538 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 945713004539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945713004540 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713004541 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 945713004542 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 945713004543 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 945713004544 carboxyltransferase (CT) interaction site; other site 945713004545 biotinylation site [posttranslational modification]; other site 945713004546 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 945713004547 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 945713004548 oxyanion hole [active] 945713004549 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 945713004550 catalytic triad [active] 945713004551 Sporulation related domain; Region: SPOR; pfam05036 945713004552 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 945713004553 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 945713004554 dimer interface [polypeptide binding]; other site 945713004555 ssDNA binding site [nucleotide binding]; other site 945713004556 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945713004557 gliding motility-associated protein GldE; Region: GldE; TIGR03520 945713004558 Domain of unknown function DUF21; Region: DUF21; pfam01595 945713004559 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945713004560 Transporter associated domain; Region: CorC_HlyC; smart01091 945713004561 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 945713004562 mce related protein; Region: MCE; pfam02470 945713004563 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 945713004564 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 945713004565 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 945713004566 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 945713004567 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 945713004568 active site 945713004569 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 945713004570 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 945713004571 active site 945713004572 HIGH motif; other site 945713004573 dimer interface [polypeptide binding]; other site 945713004574 KMSKS motif; other site 945713004575 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 945713004576 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 945713004577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 945713004578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945713004579 RNA binding surface [nucleotide binding]; other site 945713004580 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 945713004581 active site 945713004582 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 945713004583 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 945713004584 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 945713004585 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 945713004586 dimer interface [polypeptide binding]; other site 945713004587 putative anticodon binding site; other site 945713004588 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 945713004589 motif 1; other site 945713004590 active site 945713004591 motif 2; other site 945713004592 motif 3; other site 945713004593 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 945713004594 C-terminal peptidase (prc); Region: prc; TIGR00225 945713004595 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 945713004596 protein binding site [polypeptide binding]; other site 945713004597 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 945713004598 Catalytic dyad [active] 945713004599 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 945713004600 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 945713004601 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 945713004602 trimer interface [polypeptide binding]; other site 945713004603 putative metal binding site [ion binding]; other site 945713004604 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 945713004605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 945713004606 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 945713004607 active site 945713004608 DNA binding site [nucleotide binding] 945713004609 Int/Topo IB signature motif; other site 945713004610 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 945713004611 30S subunit binding site; other site 945713004612 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 945713004613 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 945713004614 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 945713004615 Hpr binding site; other site 945713004616 active site 945713004617 homohexamer subunit interaction site [polypeptide binding]; other site 945713004618 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 945713004619 Peptidase family M23; Region: Peptidase_M23; pfam01551 945713004620 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 945713004621 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 945713004622 DNA polymerase III subunit delta'; Validated; Region: PRK08485 945713004623 putative acyltransferase; Provisional; Region: PRK05790 945713004624 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 945713004625 dimer interface [polypeptide binding]; other site 945713004626 active site 945713004627 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 945713004628 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 945713004629 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 945713004630 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 945713004631 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 945713004632 Cl- selectivity filter; other site 945713004633 Cl- binding residues [ion binding]; other site 945713004634 pore gating glutamate residue; other site 945713004635 dimer interface [polypeptide binding]; other site 945713004636 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 945713004637 TrkA-C domain; Region: TrkA_C; pfam02080 945713004638 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 945713004639 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 945713004640 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 945713004641 P loop; other site 945713004642 GTP binding site [chemical binding]; other site 945713004643 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 945713004644 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 945713004645 active site 945713004646 catalytic triad [active] 945713004647 Family description; Region: VCBS; pfam13517 945713004648 Family description; Region: VCBS; pfam13517 945713004649 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004650 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 945713004651 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 945713004652 active site 945713004653 tetramer interface [polypeptide binding]; other site 945713004654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713004655 active site 945713004656 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 945713004657 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 945713004658 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 945713004659 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945713004660 DNA binding residues [nucleotide binding] 945713004661 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 945713004662 Dehydroquinase class II; Region: DHquinase_II; pfam01220 945713004663 active site 945713004664 trimer interface [polypeptide binding]; other site 945713004665 dimer interface [polypeptide binding]; other site 945713004666 L-aspartate oxidase; Provisional; Region: PRK09077 945713004667 L-aspartate oxidase; Provisional; Region: PRK06175 945713004668 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 945713004669 ParB-like nuclease domain; Region: ParBc; pfam02195 945713004670 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 945713004671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 945713004672 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 945713004673 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 945713004674 P-loop; other site 945713004675 Magnesium ion binding site [ion binding]; other site 945713004676 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 945713004677 metal-dependent hydrolase; Provisional; Region: PRK00685 945713004678 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 945713004679 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 945713004680 Ligand binding site; other site 945713004681 Putative Catalytic site; other site 945713004682 DXD motif; other site 945713004683 Uncharacterized conserved protein [Function unknown]; Region: COG1624 945713004684 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 945713004685 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 945713004686 dihydropteroate synthase; Region: DHPS; TIGR01496 945713004687 substrate binding pocket [chemical binding]; other site 945713004688 dimer interface [polypeptide binding]; other site 945713004689 inhibitor binding site; inhibition site 945713004690 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 945713004691 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 945713004692 substrate binding site [chemical binding]; other site 945713004693 hexamer interface [polypeptide binding]; other site 945713004694 metal binding site [ion binding]; metal-binding site 945713004695 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945713004696 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945713004697 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 945713004698 Domain of unknown function (DUF814); Region: DUF814; pfam05670 945713004699 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713004700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713004701 ligand binding site [chemical binding]; other site 945713004702 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713004703 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713004704 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713004705 ligand binding site [chemical binding]; other site 945713004706 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 945713004707 putative transporter; Provisional; Region: PRK11660 945713004708 Sulfate transporter family; Region: Sulfate_transp; pfam00916 945713004709 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 945713004710 SpoVG; Region: SpoVG; cl00915 945713004711 Predicted transcriptional regulator [Transcription]; Region: COG2378 945713004712 HTH domain; Region: HTH_11; cl17392 945713004713 WYL domain; Region: WYL; pfam13280 945713004714 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 945713004715 active site 945713004716 prephenate dehydrogenase; Validated; Region: PRK06545 945713004717 prephenate dehydrogenase; Validated; Region: PRK08507 945713004718 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 945713004719 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 945713004720 Chorismate mutase type II; Region: CM_2; smart00830 945713004721 Prephenate dehydratase; Region: PDT; pfam00800 945713004722 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 945713004723 putative L-Phe binding site [chemical binding]; other site 945713004724 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 945713004725 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 945713004726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713004727 FeS/SAM binding site; other site 945713004728 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 945713004729 nucleoside/Zn binding site; other site 945713004730 dimer interface [polypeptide binding]; other site 945713004731 catalytic motif [active] 945713004732 adenylate kinase; Reviewed; Region: adk; PRK00279 945713004733 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 945713004734 AMP-binding site [chemical binding]; other site 945713004735 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 945713004736 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 945713004737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713004738 Walker A/P-loop; other site 945713004739 ATP binding site [chemical binding]; other site 945713004740 Q-loop/lid; other site 945713004741 ABC transporter signature motif; other site 945713004742 Walker B; other site 945713004743 D-loop; other site 945713004744 H-loop/switch region; other site 945713004745 Methyltransferase domain; Region: Methyltransf_11; pfam08241 945713004746 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 945713004747 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 945713004748 transcription termination factor Rho; Provisional; Region: rho; PRK09376 945713004749 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 945713004750 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 945713004751 RNA binding site [nucleotide binding]; other site 945713004752 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 945713004753 multimer interface [polypeptide binding]; other site 945713004754 Walker A motif; other site 945713004755 ATP binding site [chemical binding]; other site 945713004756 Walker B motif; other site 945713004757 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 945713004758 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945713004759 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 945713004760 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 945713004761 heterodimer interface [polypeptide binding]; other site 945713004762 active site 945713004763 FMN binding site [chemical binding]; other site 945713004764 homodimer interface [polypeptide binding]; other site 945713004765 substrate binding site [chemical binding]; other site 945713004766 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 945713004767 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 945713004768 FAD binding pocket [chemical binding]; other site 945713004769 FAD binding motif [chemical binding]; other site 945713004770 phosphate binding motif [ion binding]; other site 945713004771 beta-alpha-beta structure motif; other site 945713004772 NAD binding pocket [chemical binding]; other site 945713004773 Iron coordination center [ion binding]; other site 945713004774 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 945713004775 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 945713004776 Substrate binding site; other site 945713004777 Cupin domain; Region: Cupin_2; cl17218 945713004778 alanine racemase; Reviewed; Region: alr; PRK00053 945713004779 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 945713004780 active site 945713004781 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 945713004782 dimer interface [polypeptide binding]; other site 945713004783 substrate binding site [chemical binding]; other site 945713004784 catalytic residues [active] 945713004785 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 945713004786 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 945713004787 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 945713004788 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 945713004789 NADH dehydrogenase subunit D; Validated; Region: PRK06075 945713004790 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 945713004791 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 945713004792 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 945713004793 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713004794 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 945713004795 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 945713004796 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 945713004797 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 945713004798 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 945713004799 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713004800 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 945713004801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713004802 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 945713004803 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713004804 Rrf2 family protein; Region: rrf2_super; TIGR00738 945713004805 Transcriptional regulator; Region: Rrf2; pfam02082 945713004806 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 945713004807 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 945713004808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713004809 catalytic residue [active] 945713004810 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 945713004811 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 945713004812 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 945713004813 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 945713004814 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 945713004815 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 945713004816 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 945713004817 gamma subunit interface [polypeptide binding]; other site 945713004818 epsilon subunit interface [polypeptide binding]; other site 945713004819 LBP interface [polypeptide binding]; other site 945713004820 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 945713004821 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 945713004822 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 945713004823 alpha subunit interaction interface [polypeptide binding]; other site 945713004824 Walker A motif; other site 945713004825 ATP binding site [chemical binding]; other site 945713004826 Walker B motif; other site 945713004827 inhibitor binding site; inhibition site 945713004828 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 945713004829 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 945713004830 generic binding surface II; other site 945713004831 generic binding surface I; other site 945713004832 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 945713004833 PLD-like domain; Region: PLDc_2; pfam13091 945713004834 putative active site [active] 945713004835 catalytic site [active] 945713004836 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 945713004837 putative active site [active] 945713004838 catalytic site [active] 945713004839 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004840 NHL repeat; Region: NHL; pfam01436 945713004841 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 945713004842 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713004843 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713004844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713004845 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713004846 Interdomain contacts; other site 945713004847 Cytokine receptor motif; other site 945713004848 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 945713004849 generic binding surface II; other site 945713004850 generic binding surface I; other site 945713004851 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713004852 lipoyl synthase; Provisional; Region: PRK05481 945713004853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713004854 FeS/SAM binding site; other site 945713004855 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945713004856 E3 interaction surface; other site 945713004857 lipoyl attachment site [posttranslational modification]; other site 945713004858 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 945713004859 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945713004860 E3 interaction surface; other site 945713004861 lipoyl attachment site [posttranslational modification]; other site 945713004862 e3 binding domain; Region: E3_binding; pfam02817 945713004863 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 945713004864 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 945713004865 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 945713004866 TPP-binding site [chemical binding]; other site 945713004867 tetramer interface [polypeptide binding]; other site 945713004868 heterodimer interface [polypeptide binding]; other site 945713004869 phosphorylation loop region [posttranslational modification] 945713004870 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 945713004871 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 945713004872 alpha subunit interface [polypeptide binding]; other site 945713004873 TPP binding site [chemical binding]; other site 945713004874 heterodimer interface [polypeptide binding]; other site 945713004875 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713004876 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 945713004877 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 945713004878 metal binding triad [ion binding]; metal-binding site 945713004879 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 945713004880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713004881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713004882 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945713004883 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 945713004884 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 945713004885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945713004886 active site residue [active] 945713004887 Sulphur transport; Region: Sulf_transp; pfam04143 945713004888 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 945713004889 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 945713004890 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 945713004891 4Fe-4S binding domain; Region: Fer4; pfam00037 945713004892 thiosulfate reductase PhsA; Provisional; Region: PRK15488 945713004893 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 945713004894 putative [Fe4-S4] binding site [ion binding]; other site 945713004895 putative molybdopterin cofactor binding site [chemical binding]; other site 945713004896 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 945713004897 putative molybdopterin cofactor binding site; other site 945713004898 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 945713004899 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 945713004900 DNA binding residues [nucleotide binding] 945713004901 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 945713004902 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 945713004903 intrachain domain interface; other site 945713004904 interchain domain interface [polypeptide binding]; other site 945713004905 heme bH binding site [chemical binding]; other site 945713004906 heme bL binding site [chemical binding]; other site 945713004907 Qo binding site; other site 945713004908 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 945713004909 iron-sulfur cluster [ion binding]; other site 945713004910 [2Fe-2S] cluster binding site [ion binding]; other site 945713004911 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 945713004912 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 945713004913 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 945713004914 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 945713004915 acyl-activating enzyme (AAE) consensus motif; other site 945713004916 putative AMP binding site [chemical binding]; other site 945713004917 putative active site [active] 945713004918 putative CoA binding site [chemical binding]; other site 945713004919 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 945713004920 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 945713004921 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 945713004922 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 945713004923 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 945713004924 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 945713004925 dimer interface [polypeptide binding]; other site 945713004926 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 945713004927 active site 945713004928 Fe binding site [ion binding]; other site 945713004929 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 945713004930 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 945713004931 minor groove reading motif; other site 945713004932 helix-hairpin-helix signature motif; other site 945713004933 substrate binding pocket [chemical binding]; other site 945713004934 active site 945713004935 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 945713004936 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 945713004937 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 945713004938 active site 945713004939 substrate binding site [chemical binding]; other site 945713004940 metal binding site [ion binding]; metal-binding site 945713004941 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 945713004942 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 945713004943 metal ion-dependent adhesion site (MIDAS); other site 945713004944 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 945713004945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713004946 binding surface 945713004947 TPR motif; other site 945713004948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 945713004949 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 945713004950 nucleotide binding site/active site [active] 945713004951 HIT family signature motif; other site 945713004952 catalytic residue [active] 945713004953 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 945713004954 elongation factor G; Reviewed; Region: PRK12740 945713004955 G1 box; other site 945713004956 putative GEF interaction site [polypeptide binding]; other site 945713004957 GTP/Mg2+ binding site [chemical binding]; other site 945713004958 Switch I region; other site 945713004959 G2 box; other site 945713004960 G3 box; other site 945713004961 Switch II region; other site 945713004962 G4 box; other site 945713004963 G5 box; other site 945713004964 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 945713004965 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 945713004966 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 945713004967 YtxH-like protein; Region: YtxH; pfam12732 945713004968 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 945713004969 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 945713004970 Maf-like protein; Region: Maf; pfam02545 945713004971 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 945713004972 active site 945713004973 dimer interface [polypeptide binding]; other site 945713004974 Stage II sporulation protein; Region: SpoIID; pfam08486 945713004975 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 945713004976 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 945713004977 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 945713004978 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 945713004979 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713004980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713004981 NAD(P) binding site [chemical binding]; other site 945713004982 active site 945713004983 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 945713004984 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 945713004985 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713004986 catalytic residue [active] 945713004987 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 945713004988 active site 945713004989 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713004990 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 945713004991 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713004992 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 945713004993 FtsX-like permease family; Region: FtsX; pfam02687 945713004994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713004995 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 945713004996 FtsX-like permease family; Region: FtsX; pfam02687 945713004997 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713004998 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945713004999 Walker A/P-loop; other site 945713005000 ATP binding site [chemical binding]; other site 945713005001 Q-loop/lid; other site 945713005002 ABC transporter signature motif; other site 945713005003 Walker B; other site 945713005004 D-loop; other site 945713005005 H-loop/switch region; other site 945713005006 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713005007 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 945713005008 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713005009 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 945713005010 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 945713005011 active site 945713005012 NTP binding site [chemical binding]; other site 945713005013 metal binding triad [ion binding]; metal-binding site 945713005014 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 945713005015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713005016 Zn2+ binding site [ion binding]; other site 945713005017 Mg2+ binding site [ion binding]; other site 945713005018 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 945713005019 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 945713005020 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 945713005021 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 945713005022 hinge; other site 945713005023 active site 945713005024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 945713005025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 945713005026 active site 945713005027 ATP binding site [chemical binding]; other site 945713005028 substrate binding site [chemical binding]; other site 945713005029 activation loop (A-loop); other site 945713005030 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 945713005031 active site 945713005032 trigger factor; Region: tig; TIGR00115 945713005033 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 945713005034 Clp protease; Region: CLP_protease; pfam00574 945713005035 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 945713005036 oligomer interface [polypeptide binding]; other site 945713005037 active site residues [active] 945713005038 Beta-lactamase; Region: Beta-lactamase; pfam00144 945713005039 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 945713005040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005041 binding surface 945713005042 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713005043 TPR motif; other site 945713005044 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 945713005045 metal ion-dependent adhesion site (MIDAS); other site 945713005046 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 945713005047 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 945713005048 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 945713005049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713005050 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713005051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713005052 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713005053 putative active site [active] 945713005054 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 945713005055 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005056 putative transposase OrfB; Reviewed; Region: PHA02517 945713005057 Homeodomain-like domain; Region: HTH_32; pfam13565 945713005058 Integrase core domain; Region: rve; pfam00665 945713005059 Integrase core domain; Region: rve_3; pfam13683 945713005060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713005061 Transposase; Region: HTH_Tnp_1; pfam01527 945713005062 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 945713005063 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005064 AIR carboxylase; Region: AIRC; pfam00731 945713005065 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 945713005066 ATP-grasp domain; Region: ATP-grasp; pfam02222 945713005067 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 945713005068 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 945713005069 Competence protein; Region: Competence; pfam03772 945713005070 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 945713005071 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 945713005072 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 945713005073 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 945713005074 putative active site [active] 945713005075 dimerization interface [polypeptide binding]; other site 945713005076 putative tRNAtyr binding site [nucleotide binding]; other site 945713005077 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 945713005078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713005079 S-adenosylmethionine binding site [chemical binding]; other site 945713005080 PEGA domain; Region: PEGA; pfam08308 945713005081 PQQ-like domain; Region: PQQ_2; pfam13360 945713005082 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 945713005083 Trp docking motif [polypeptide binding]; other site 945713005084 active site 945713005085 PQQ-like domain; Region: PQQ_2; pfam13360 945713005086 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 945713005087 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713005088 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 945713005089 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 945713005090 dimer interface [polypeptide binding]; other site 945713005091 active site 945713005092 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 945713005093 dimer interface [polypeptide binding]; other site 945713005094 active site 945713005095 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 945713005096 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 945713005097 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 945713005098 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 945713005099 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 945713005100 dimerization domain swap beta strand [polypeptide binding]; other site 945713005101 regulatory protein interface [polypeptide binding]; other site 945713005102 active site 945713005103 regulatory phosphorylation site [posttranslational modification]; other site 945713005104 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 945713005105 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 945713005106 substrate binding pocket [chemical binding]; other site 945713005107 chain length determination region; other site 945713005108 substrate-Mg2+ binding site; other site 945713005109 catalytic residues [active] 945713005110 aspartate-rich region 1; other site 945713005111 active site lid residues [active] 945713005112 aspartate-rich region 2; other site 945713005113 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 945713005114 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 945713005115 homotetramer interface [polypeptide binding]; other site 945713005116 FMN binding site [chemical binding]; other site 945713005117 homodimer contacts [polypeptide binding]; other site 945713005118 putative active site [active] 945713005119 putative substrate binding site [chemical binding]; other site 945713005120 aminodeoxychorismate synthase; Provisional; Region: PRK07508 945713005121 chorismate binding enzyme; Region: Chorismate_bind; cl10555 945713005122 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 945713005123 Aminotransferase class IV; Region: Aminotran_4; pfam01063 945713005124 substrate-cofactor binding pocket; other site 945713005125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713005126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713005127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713005128 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713005129 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 945713005130 putative NAD(P) binding site [chemical binding]; other site 945713005131 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 945713005132 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 945713005133 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 945713005134 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945713005135 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713005136 active site 945713005137 catalytic site [active] 945713005138 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 945713005139 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 945713005140 SmpB-tmRNA interface; other site 945713005141 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 945713005142 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 945713005143 active site 945713005144 HIGH motif; other site 945713005145 dimer interface [polypeptide binding]; other site 945713005146 KMSKS motif; other site 945713005147 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 945713005148 RNA binding surface [nucleotide binding]; other site 945713005149 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 945713005150 Integral membrane protein TerC family; Region: TerC; cl10468 945713005151 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 945713005152 Na binding site [ion binding]; other site 945713005153 Thiamine pyrophosphokinase; Region: TPK; cd07995 945713005154 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 945713005155 active site 945713005156 dimerization interface [polypeptide binding]; other site 945713005157 thiamine binding site [chemical binding]; other site 945713005158 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713005159 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 945713005160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713005161 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 945713005162 N-acetyl-D-glucosamine binding site [chemical binding]; other site 945713005163 catalytic residue [active] 945713005164 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005165 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005166 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 945713005167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005168 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005169 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 945713005170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005171 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 945713005172 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005173 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 945713005174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 945713005175 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 945713005176 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945713005177 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945713005178 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713005179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713005180 Walker A/P-loop; other site 945713005181 ATP binding site [chemical binding]; other site 945713005182 Q-loop/lid; other site 945713005183 ABC transporter signature motif; other site 945713005184 Walker B; other site 945713005185 D-loop; other site 945713005186 H-loop/switch region; other site 945713005187 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 945713005188 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 945713005189 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 945713005190 Tetramer interface [polypeptide binding]; other site 945713005191 active site 945713005192 FMN-binding site [chemical binding]; other site 945713005193 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 945713005194 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713005195 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945713005196 protein binding site [polypeptide binding]; other site 945713005197 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945713005198 protein binding site [polypeptide binding]; other site 945713005199 Recombination protein O N terminal; Region: RecO_N; pfam11967 945713005200 DNA repair protein RecO; Region: reco; TIGR00613 945713005201 Recombination protein O C terminal; Region: RecO_C; pfam02565 945713005202 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 945713005203 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 945713005204 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 945713005205 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 945713005206 substrate binding site [chemical binding]; other site 945713005207 ATP binding site [chemical binding]; other site 945713005208 Protein of unknown function DUF86; Region: DUF86; pfam01934 945713005209 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 945713005210 active site 945713005211 NTP binding site [chemical binding]; other site 945713005212 metal binding triad [ion binding]; metal-binding site 945713005213 antibiotic binding site [chemical binding]; other site 945713005214 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 945713005215 nudix motif; other site 945713005216 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 945713005217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713005218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713005219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713005220 dimer interface [polypeptide binding]; other site 945713005221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713005222 ATP binding site [chemical binding]; other site 945713005223 Mg2+ binding site [ion binding]; other site 945713005224 G-X-G motif; other site 945713005225 Response regulator receiver domain; Region: Response_reg; pfam00072 945713005226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005227 active site 945713005228 phosphorylation site [posttranslational modification] 945713005229 intermolecular recognition site; other site 945713005230 dimerization interface [polypeptide binding]; other site 945713005231 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713005232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005233 active site 945713005234 phosphorylation site [posttranslational modification] 945713005235 intermolecular recognition site; other site 945713005236 Response regulator receiver domain; Region: Response_reg; pfam00072 945713005237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005238 active site 945713005239 phosphorylation site [posttranslational modification] 945713005240 intermolecular recognition site; other site 945713005241 dimerization interface [polypeptide binding]; other site 945713005242 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 945713005243 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 945713005244 active site 945713005245 HIGH motif; other site 945713005246 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 945713005247 active site 945713005248 KMSKS motif; other site 945713005249 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 945713005250 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945713005251 active site 945713005252 HIGH motif; other site 945713005253 nucleotide binding site [chemical binding]; other site 945713005254 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 945713005255 KMSKS motif; other site 945713005256 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 945713005257 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945713005258 active site residue [active] 945713005259 Methylamine utilisation protein MauE; Region: MauE; pfam07291 945713005260 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 945713005261 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 945713005262 active site 945713005263 PHP Thumb interface [polypeptide binding]; other site 945713005264 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 945713005265 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 945713005266 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 945713005267 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 945713005268 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 945713005269 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 945713005270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713005271 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 945713005272 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 945713005273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 945713005274 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 945713005275 active site 945713005276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 945713005277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 945713005278 active site 945713005279 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713005280 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713005281 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713005282 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713005283 GIY-YIG motif/motif A; other site 945713005284 putative active site [active] 945713005285 putative metal binding site [ion binding]; other site 945713005286 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713005287 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713005288 N-terminal plug; other site 945713005289 ligand-binding site [chemical binding]; other site 945713005290 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713005291 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713005292 N-terminal plug; other site 945713005293 ligand-binding site [chemical binding]; other site 945713005294 BNR repeat-like domain; Region: BNR_2; pfam13088 945713005295 BNR repeat-like domain; Region: BNR_2; pfam13088 945713005296 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005297 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713005298 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713005299 FMN-binding domain; Region: FMN_bind; pfam04205 945713005300 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713005301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713005302 Zn2+ binding site [ion binding]; other site 945713005303 Mg2+ binding site [ion binding]; other site 945713005304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945713005305 catalytic core [active] 945713005306 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 945713005307 cyclase homology domain; Region: CHD; cd07302 945713005308 dimer interface [polypeptide binding]; other site 945713005309 nucleotidyl binding site; other site 945713005310 metal binding site [ion binding]; metal-binding site 945713005311 Predicted integral membrane protein [Function unknown]; Region: COG5616 945713005312 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 945713005313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005314 TPR motif; other site 945713005315 binding surface 945713005316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005317 TPR motif; other site 945713005318 binding surface 945713005319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005320 binding surface 945713005321 TPR motif; other site 945713005322 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 945713005323 nucleotidyl binding site; other site 945713005324 metal binding site [ion binding]; metal-binding site 945713005325 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 945713005326 Malic enzyme, N-terminal domain; Region: malic; pfam00390 945713005327 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 945713005328 putative NAD(P) binding site [chemical binding]; other site 945713005329 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 945713005330 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 945713005331 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713005332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713005333 active site 945713005334 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 945713005335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713005336 probable molybdenum cofactor biosynthesis protein A, archaeal; Region: moaA_archaeal; TIGR02668 945713005337 FeS/SAM binding site; other site 945713005338 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 945713005339 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 945713005340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 945713005341 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 945713005342 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 945713005343 hinge; other site 945713005344 active site 945713005345 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945713005346 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 945713005347 intersubunit interface [polypeptide binding]; other site 945713005348 active site 945713005349 catalytic residue [active] 945713005350 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 945713005351 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 945713005352 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 945713005353 homodimer interface [polypeptide binding]; other site 945713005354 NADP binding site [chemical binding]; other site 945713005355 substrate binding site [chemical binding]; other site 945713005356 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 945713005357 DNA methylase; Region: N6_N4_Mtase; pfam01555 945713005358 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 945713005359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713005360 putative active site [active] 945713005361 metal binding site [ion binding]; metal-binding site 945713005362 homodimer binding site [polypeptide binding]; other site 945713005363 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 945713005364 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 945713005365 active site 945713005366 catalytic site [active] 945713005367 substrate binding site [chemical binding]; other site 945713005368 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 945713005369 GIY-YIG motif/motif A; other site 945713005370 active site 945713005371 catalytic site [active] 945713005372 putative DNA binding site [nucleotide binding]; other site 945713005373 metal binding site [ion binding]; metal-binding site 945713005374 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 945713005375 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184 945713005376 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 945713005377 multidrug efflux protein; Reviewed; Region: PRK01766 945713005378 cation binding site [ion binding]; other site 945713005379 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 945713005380 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 945713005381 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 945713005382 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 945713005383 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713005384 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 945713005385 B12 binding site [chemical binding]; other site 945713005386 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713005387 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713005388 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713005389 ligand binding site [chemical binding]; other site 945713005390 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005391 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005392 Bacterial Ig-like domain; Region: Big_5; pfam13205 945713005393 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 945713005394 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 945713005395 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 945713005396 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713005397 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005398 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 945713005399 active site 945713005400 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 945713005401 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005402 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005403 BNR repeat-like domain; Region: BNR_2; pfam13088 945713005404 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713005405 VPS10 domain; Region: VPS10; smart00602 945713005406 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 945713005407 putative catalytic site [active] 945713005408 putative metal binding site [ion binding]; other site 945713005409 putative phosphate binding site [ion binding]; other site 945713005410 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 945713005411 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 945713005412 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 945713005413 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 945713005414 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 945713005415 heme-binding residues [chemical binding]; other site 945713005416 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 945713005417 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 945713005418 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 945713005419 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 945713005420 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 945713005421 Ligand binding site [chemical binding]; other site 945713005422 Electron transfer flavoprotein domain; Region: ETF; pfam01012 945713005423 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 945713005424 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 945713005425 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 945713005426 Bifunctional nuclease; Region: DNase-RNase; pfam02577 945713005427 UvrB/uvrC motif; Region: UVR; pfam02151 945713005428 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 945713005429 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 945713005430 active site 945713005431 dimer interface [polypeptide binding]; other site 945713005432 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 945713005433 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 945713005434 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 945713005435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 945713005436 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 945713005437 rod shape-determining protein MreC; Provisional; Region: PRK13922 945713005438 rod shape-determining protein MreC; Region: MreC; pfam04085 945713005439 rod shape-determining protein MreB; Provisional; Region: PRK13927 945713005440 MreB and similar proteins; Region: MreB_like; cd10225 945713005441 nucleotide binding site [chemical binding]; other site 945713005442 Mg binding site [ion binding]; other site 945713005443 putative protofilament interaction site [polypeptide binding]; other site 945713005444 RodZ interaction site [polypeptide binding]; other site 945713005445 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 945713005446 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 945713005447 purine monophosphate binding site [chemical binding]; other site 945713005448 dimer interface [polypeptide binding]; other site 945713005449 putative catalytic residues [active] 945713005450 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 945713005451 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 945713005452 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 945713005453 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 945713005454 active site 945713005455 substrate binding site [chemical binding]; other site 945713005456 cosubstrate binding site; other site 945713005457 catalytic site [active] 945713005458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713005459 TPR motif; other site 945713005460 binding surface 945713005461 CTP synthetase; Validated; Region: pyrG; PRK05380 945713005462 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 945713005463 Catalytic site [active] 945713005464 active site 945713005465 UTP binding site [chemical binding]; other site 945713005466 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 945713005467 active site 945713005468 putative oxyanion hole; other site 945713005469 catalytic triad [active] 945713005470 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713005471 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713005472 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 945713005473 Sel1-like repeats; Region: SEL1; smart00671 945713005474 Sel1-like repeats; Region: SEL1; smart00671 945713005475 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 945713005476 Sel1-like repeats; Region: SEL1; smart00671 945713005477 methionine aminotransferase; Validated; Region: PRK09082 945713005478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 945713005479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713005480 homodimer interface [polypeptide binding]; other site 945713005481 catalytic residue [active] 945713005482 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 945713005483 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 945713005484 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 945713005485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713005486 putative substrate translocation pore; other site 945713005487 transcription antitermination factor NusB; Region: nusB; TIGR01951 945713005488 putative RNA binding site [nucleotide binding]; other site 945713005489 Uncharacterized conserved protein [Function unknown]; Region: COG1434 945713005490 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 945713005491 putative active site [active] 945713005492 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 945713005493 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 945713005494 Predicted integral membrane protein [Function unknown]; Region: COG5652 945713005495 Uncharacterized conserved protein [Function unknown]; Region: COG0062 945713005496 putative carbohydrate kinase; Provisional; Region: PRK10565 945713005497 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 945713005498 putative substrate binding site [chemical binding]; other site 945713005499 putative ATP binding site [chemical binding]; other site 945713005500 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 945713005501 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713005502 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 945713005503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713005504 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 945713005505 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 945713005506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 945713005507 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 945713005508 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 945713005509 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 945713005510 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 945713005511 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 945713005512 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 945713005513 putative dimer interface [polypeptide binding]; other site 945713005514 putative anticodon binding site; other site 945713005515 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 945713005516 homodimer interface [polypeptide binding]; other site 945713005517 motif 1; other site 945713005518 motif 2; other site 945713005519 active site 945713005520 motif 3; other site 945713005521 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 945713005522 Peptidase family C69; Region: Peptidase_C69; cl17793 945713005523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 945713005524 nucleotide binding region [chemical binding]; other site 945713005525 ATP-binding site [chemical binding]; other site 945713005526 FeoA domain; Region: FeoA; pfam04023 945713005527 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 945713005528 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 945713005529 G1 box; other site 945713005530 GTP/Mg2+ binding site [chemical binding]; other site 945713005531 G2 box; other site 945713005532 Switch I region; other site 945713005533 G3 box; other site 945713005534 Switch II region; other site 945713005535 G4 box; other site 945713005536 G5 box; other site 945713005537 Nucleoside recognition; Region: Gate; pfam07670 945713005538 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 945713005539 Nucleoside recognition; Region: Gate; pfam07670 945713005540 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 945713005541 metal binding site 2 [ion binding]; metal-binding site 945713005542 putative DNA binding helix; other site 945713005543 metal binding site 1 [ion binding]; metal-binding site 945713005544 dimer interface [polypeptide binding]; other site 945713005545 structural Zn2+ binding site [ion binding]; other site 945713005546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 945713005547 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713005548 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713005549 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713005550 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713005551 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713005552 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 945713005553 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 945713005554 Peptidase family M28; Region: Peptidase_M28; pfam04389 945713005555 metal binding site [ion binding]; metal-binding site 945713005556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 945713005557 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 945713005558 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 945713005559 Low molecular weight phosphatase family; Region: LMWPc; cd00115 945713005560 active site 945713005561 Fructosamine kinase; Region: Fructosamin_kin; cl17579 945713005562 Phosphotransferase enzyme family; Region: APH; pfam01636 945713005563 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 945713005564 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 945713005565 starch-binding site 2 [chemical binding]; other site 945713005566 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 945713005567 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 945713005568 Right handed beta helix region; Region: Beta_helix; pfam13229 945713005569 eIF3 subunit 6 N terminal domain; Region: eIF3_N; pfam09440 945713005570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 945713005571 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 945713005572 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 945713005573 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 945713005574 Walker A/P-loop; other site 945713005575 ATP binding site [chemical binding]; other site 945713005576 Q-loop/lid; other site 945713005577 ABC transporter signature motif; other site 945713005578 Walker B; other site 945713005579 D-loop; other site 945713005580 H-loop/switch region; other site 945713005581 OstA-like protein; Region: OstA; cl00844 945713005582 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 945713005583 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 945713005584 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 945713005585 putative active site [active] 945713005586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 945713005587 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 945713005588 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 945713005589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713005590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713005591 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 945713005592 PhoU domain; Region: PhoU; pfam01895 945713005593 PhoU domain; Region: PhoU; pfam01895 945713005594 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 945713005595 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 945713005596 Walker A/P-loop; other site 945713005597 ATP binding site [chemical binding]; other site 945713005598 Q-loop/lid; other site 945713005599 ABC transporter signature motif; other site 945713005600 Walker B; other site 945713005601 D-loop; other site 945713005602 H-loop/switch region; other site 945713005603 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 945713005604 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 945713005605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713005606 dimer interface [polypeptide binding]; other site 945713005607 conserved gate region; other site 945713005608 putative PBP binding loops; other site 945713005609 ABC-ATPase subunit interface; other site 945713005610 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 945713005611 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 945713005612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713005613 dimer interface [polypeptide binding]; other site 945713005614 conserved gate region; other site 945713005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 945713005616 PBP superfamily domain; Region: PBP_like_2; cl17296 945713005617 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 945713005618 Na binding site [ion binding]; other site 945713005619 Domain of unknown function (DUF386); Region: DUF386; cl01047 945713005620 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 945713005621 Zn binding site [ion binding]; other site 945713005622 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 945713005623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713005624 Walker A motif; other site 945713005625 ATP binding site [chemical binding]; other site 945713005626 Walker B motif; other site 945713005627 arginine finger; other site 945713005628 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 945713005629 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 945713005630 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 945713005631 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 945713005632 nucleotide binding site [chemical binding]; other site 945713005633 NEF interaction site [polypeptide binding]; other site 945713005634 SBD interface [polypeptide binding]; other site 945713005635 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 945713005636 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 945713005637 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 945713005638 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 945713005639 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 945713005640 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 945713005641 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 945713005642 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 945713005643 Glycoprotease family; Region: Peptidase_M22; pfam00814 945713005644 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 945713005645 Response regulator receiver domain; Region: Response_reg; pfam00072 945713005646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005647 active site 945713005648 phosphorylation site [posttranslational modification] 945713005649 intermolecular recognition site; other site 945713005650 dimerization interface [polypeptide binding]; other site 945713005651 PglZ domain; Region: PglZ; pfam08665 945713005652 cell surface protein SprA; Region: surface_SprA; TIGR04189 945713005653 Motility related/secretion protein; Region: SprA_N; pfam14349 945713005654 Motility related/secretion protein; Region: SprA_N; pfam14349 945713005655 Motility related/secretion protein; Region: SprA_N; pfam14349 945713005656 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 945713005657 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713005658 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 945713005659 PA/protease or protease-like domain interface [polypeptide binding]; other site 945713005660 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 945713005661 metal binding site [ion binding]; metal-binding site 945713005662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713005663 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 945713005664 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 945713005665 active site lid residues [active] 945713005666 substrate binding pocket [chemical binding]; other site 945713005667 catalytic residues [active] 945713005668 substrate-Mg2+ binding site; other site 945713005669 aspartate-rich region 1; other site 945713005670 aspartate-rich region 2; other site 945713005671 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 945713005672 active site lid residues [active] 945713005673 substrate binding pocket [chemical binding]; other site 945713005674 catalytic residues [active] 945713005675 substrate-Mg2+ binding site; other site 945713005676 aspartate-rich region 1; other site 945713005677 aspartate-rich region 2; other site 945713005678 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 945713005679 anti sigma factor interaction site; other site 945713005680 regulatory phosphorylation site [posttranslational modification]; other site 945713005681 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005682 Transposase IS200 like; Region: Y1_Tnp; pfam01797 945713005683 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 945713005684 HicB family; Region: HicB; pfam05534 945713005685 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 945713005686 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 945713005687 Transposase IS200 like; Region: Y1_Tnp; pfam01797 945713005688 Methyltransferase domain; Region: Methyltransf_26; pfam13659 945713005689 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 945713005690 PLD-like domain; Region: PLDc_2; pfam13091 945713005691 putative homodimer interface [polypeptide binding]; other site 945713005692 putative active site [active] 945713005693 catalytic site [active] 945713005694 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 945713005695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713005696 ATP binding site [chemical binding]; other site 945713005697 putative Mg++ binding site [ion binding]; other site 945713005698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713005699 nucleotide binding region [chemical binding]; other site 945713005700 ATP-binding site [chemical binding]; other site 945713005701 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 945713005702 active site 945713005703 catalytic site [active] 945713005704 substrate binding site [chemical binding]; other site 945713005705 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 945713005706 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 945713005707 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713005708 putative catalytic residues [active] 945713005709 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 945713005710 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 945713005711 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713005712 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713005713 ligand binding site [chemical binding]; other site 945713005714 flexible hinge region; other site 945713005715 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 945713005716 putative switch regulator; other site 945713005717 non-specific DNA interactions [nucleotide binding]; other site 945713005718 DNA binding site [nucleotide binding] 945713005719 sequence specific DNA binding site [nucleotide binding]; other site 945713005720 putative cAMP binding site [chemical binding]; other site 945713005721 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 945713005722 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 945713005723 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 945713005724 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 945713005725 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 945713005726 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 945713005727 DNA binding residues [nucleotide binding] 945713005728 MerT mercuric transport protein; Region: MerT; cl03578 945713005729 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945713005730 metal-binding site [ion binding] 945713005731 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945713005732 metal-binding site [ion binding] 945713005733 mercuric reductase; Region: MerA; TIGR02053 945713005734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713005735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945713005736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713005737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713005738 S-adenosylmethionine binding site [chemical binding]; other site 945713005739 YceI-like domain; Region: YceI; pfam04264 945713005740 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 945713005741 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 945713005742 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 945713005743 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 945713005744 alpha-glucosidase; Provisional; Region: PRK10137 945713005745 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 945713005746 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 945713005747 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 945713005748 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 945713005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713005750 motif II; other site 945713005751 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 945713005752 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 945713005753 putative active site [active] 945713005754 catalytic residue [active] 945713005755 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 945713005756 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 945713005757 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 945713005758 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 945713005759 TPP-binding site [chemical binding]; other site 945713005760 dimer interface [polypeptide binding]; other site 945713005761 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945713005762 PYR/PP interface [polypeptide binding]; other site 945713005763 dimer interface [polypeptide binding]; other site 945713005764 TPP binding site [chemical binding]; other site 945713005765 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713005766 glucokinase, proteobacterial type; Region: glk; TIGR00749 945713005767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713005768 nucleotide binding site [chemical binding]; other site 945713005769 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 945713005770 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 945713005771 putative active site [active] 945713005772 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 945713005773 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 945713005774 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 945713005775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 945713005776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 945713005777 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 945713005778 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 945713005779 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 945713005780 Ligand binding site; other site 945713005781 Putative Catalytic site; other site 945713005782 DXD motif; other site 945713005783 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 945713005784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713005785 FeS/SAM binding site; other site 945713005786 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 945713005787 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 945713005788 Protein of unknown function, DUF547; Region: DUF547; pfam04784 945713005789 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 945713005790 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 945713005791 Probable Catalytic site; other site 945713005792 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 945713005793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 945713005794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713005795 4Fe-4S binding domain; Region: Fer4_5; pfam12801 945713005796 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 945713005797 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 945713005798 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 945713005799 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 945713005800 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 945713005801 active site 945713005802 ADP/pyrophosphate binding site [chemical binding]; other site 945713005803 dimerization interface [polypeptide binding]; other site 945713005804 allosteric effector site; other site 945713005805 fructose-1,6-bisphosphate binding site; other site 945713005806 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 945713005807 RNA/DNA hybrid binding site [nucleotide binding]; other site 945713005808 active site 945713005809 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 945713005810 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 945713005811 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 945713005812 RNA methyltransferase, RsmE family; Region: TIGR00046 945713005813 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713005814 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713005815 glycine dehydrogenase; Provisional; Region: PRK05367 945713005816 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 945713005817 tetramer interface [polypeptide binding]; other site 945713005818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713005819 catalytic residue [active] 945713005820 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 945713005821 tetramer interface [polypeptide binding]; other site 945713005822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713005823 catalytic residue [active] 945713005824 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 945713005825 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 945713005826 dimerization interface [polypeptide binding]; other site 945713005827 active site 945713005828 metal binding site [ion binding]; metal-binding site 945713005829 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 945713005830 dsRNA binding site [nucleotide binding]; other site 945713005831 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 945713005832 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 945713005833 dimer interface [polypeptide binding]; other site 945713005834 active site 945713005835 acyl carrier protein; Provisional; Region: acpP; PRK00982 945713005836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 945713005837 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 945713005838 NAD(P) binding site [chemical binding]; other site 945713005839 homotetramer interface [polypeptide binding]; other site 945713005840 homodimer interface [polypeptide binding]; other site 945713005841 active site 945713005842 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 945713005843 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 945713005844 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 945713005845 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 945713005846 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 945713005847 dimer interface [polypeptide binding]; other site 945713005848 active site 945713005849 CoA binding pocket [chemical binding]; other site 945713005850 putative phosphate acyltransferase; Provisional; Region: PRK05331 945713005851 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 945713005852 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 945713005853 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 945713005854 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 945713005855 Walker A/P-loop; other site 945713005856 ATP binding site [chemical binding]; other site 945713005857 Q-loop/lid; other site 945713005858 ABC transporter signature motif; other site 945713005859 Walker B; other site 945713005860 D-loop; other site 945713005861 H-loop/switch region; other site 945713005862 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 945713005863 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 945713005864 Protease prsW family; Region: PrsW-protease; pfam13367 945713005865 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 945713005866 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 945713005867 active site 945713005868 (T/H)XGH motif; other site 945713005869 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 945713005870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713005871 NAD(P) binding site [chemical binding]; other site 945713005872 active site 945713005873 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 945713005874 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 945713005875 Walker A; other site 945713005876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 945713005877 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 945713005878 FAD binding site [chemical binding]; other site 945713005879 homotetramer interface [polypeptide binding]; other site 945713005880 substrate binding pocket [chemical binding]; other site 945713005881 catalytic base [active] 945713005882 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 945713005883 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 945713005884 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713005885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005887 active site 945713005888 phosphorylation site [posttranslational modification] 945713005889 intermolecular recognition site; other site 945713005890 dimerization interface [polypeptide binding]; other site 945713005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713005892 DNA binding residues [nucleotide binding] 945713005893 dimerization interface [polypeptide binding]; other site 945713005894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713005895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005896 binding surface 945713005897 TPR motif; other site 945713005898 TPR repeat; Region: TPR_11; pfam13414 945713005899 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713005900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945713005901 Histidine kinase; Region: HisKA_3; pfam07730 945713005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713005903 ATP binding site [chemical binding]; other site 945713005904 Mg2+ binding site [ion binding]; other site 945713005905 G-X-G motif; other site 945713005906 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713005907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005908 active site 945713005909 phosphorylation site [posttranslational modification] 945713005910 intermolecular recognition site; other site 945713005911 dimerization interface [polypeptide binding]; other site 945713005912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713005913 Walker A motif; other site 945713005914 ATP binding site [chemical binding]; other site 945713005915 Walker B motif; other site 945713005916 arginine finger; other site 945713005917 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713005918 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 945713005919 nucleotide binding site/active site [active] 945713005920 HIT family signature motif; other site 945713005921 catalytic residue [active] 945713005922 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 945713005923 oligomeric interface; other site 945713005924 putative active site [active] 945713005925 homodimer interface [polypeptide binding]; other site 945713005926 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 945713005927 active site 945713005928 DNA polymerase IV; Validated; Region: PRK02406 945713005929 DNA binding site [nucleotide binding] 945713005930 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 945713005931 putative active site [active] 945713005932 Protein of unknown function DUF72; Region: DUF72; pfam01904 945713005933 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 945713005934 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 945713005935 LexA repressor; Validated; Region: PRK00215 945713005936 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 945713005937 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 945713005938 Catalytic site [active] 945713005939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713005940 PAS domain; Region: PAS_9; pfam13426 945713005941 putative active site [active] 945713005942 heme pocket [chemical binding]; other site 945713005943 PAS fold; Region: PAS; pfam00989 945713005944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713005945 putative active site [active] 945713005946 heme pocket [chemical binding]; other site 945713005947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713005948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713005949 dimer interface [polypeptide binding]; other site 945713005950 phosphorylation site [posttranslational modification] 945713005951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713005952 Response regulator receiver domain; Region: Response_reg; pfam00072 945713005953 active site 945713005954 phosphorylation site [posttranslational modification] 945713005955 intermolecular recognition site; other site 945713005956 dimerization interface [polypeptide binding]; other site 945713005957 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 945713005958 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 945713005959 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713005960 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 945713005961 DXD motif; other site 945713005962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005963 binding surface 945713005964 TPR motif; other site 945713005965 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713005966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713005967 binding surface 945713005968 TPR motif; other site 945713005969 TPR repeat; Region: TPR_11; pfam13414 945713005970 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713005971 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 945713005972 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 945713005973 Walker A motif; other site 945713005974 ATP binding site [chemical binding]; other site 945713005975 Walker B motif; other site 945713005976 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 945713005977 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 945713005978 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 945713005979 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 945713005980 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 945713005981 Na2 binding site [ion binding]; other site 945713005982 substrate binding site 1 [chemical binding]; other site 945713005983 Na binding site 1 [ion binding]; other site 945713005984 substrate binding site 2 [chemical binding]; other site 945713005985 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 945713005986 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 945713005987 active site 945713005988 ADP/pyrophosphate binding site [chemical binding]; other site 945713005989 dimerization interface [polypeptide binding]; other site 945713005990 allosteric effector site; other site 945713005991 fructose-1,6-bisphosphate binding site; other site 945713005992 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 945713005993 Part of AAA domain; Region: AAA_19; pfam13245 945713005994 Family description; Region: UvrD_C_2; pfam13538 945713005995 Family description; Region: VCBS; pfam13517 945713005996 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 945713005997 PQQ-like domain; Region: PQQ_2; pfam13360 945713005998 Trp docking motif [polypeptide binding]; other site 945713005999 active site 945713006000 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006001 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 945713006002 B12 binding site [chemical binding]; other site 945713006003 cobalt ligand [ion binding]; other site 945713006004 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 945713006005 HIT family signature motif; other site 945713006006 catalytic residue [active] 945713006007 D-cysteine desulfhydrase; Validated; Region: PRK03910 945713006008 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 945713006009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713006010 catalytic residue [active] 945713006011 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 945713006012 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 945713006013 Ligand binding site; other site 945713006014 oligomer interface; other site 945713006015 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 945713006016 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 945713006017 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 945713006018 putative acyl-acceptor binding pocket; other site 945713006019 Peptidase family M48; Region: Peptidase_M48; pfam01435 945713006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006021 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713006022 putative active site [active] 945713006023 heme pocket [chemical binding]; other site 945713006024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006025 putative active site [active] 945713006026 heme pocket [chemical binding]; other site 945713006027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006028 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713006029 putative active site [active] 945713006030 heme pocket [chemical binding]; other site 945713006031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006032 dimer interface [polypeptide binding]; other site 945713006033 phosphorylation site [posttranslational modification] 945713006034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006035 ATP binding site [chemical binding]; other site 945713006036 Mg2+ binding site [ion binding]; other site 945713006037 G-X-G motif; other site 945713006038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713006039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713006040 active site 945713006041 phosphorylation site [posttranslational modification] 945713006042 intermolecular recognition site; other site 945713006043 dimerization interface [polypeptide binding]; other site 945713006044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006045 binding surface 945713006046 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713006047 TPR motif; other site 945713006048 Oxygen tolerance; Region: BatD; pfam13584 945713006049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006050 binding surface 945713006051 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713006052 TPR motif; other site 945713006053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713006054 Aerotolerance regulator N-terminal; Region: BatA; cl06567 945713006055 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 945713006056 metal ion-dependent adhesion site (MIDAS); other site 945713006057 Aerotolerance regulator N-terminal; Region: BatA; cl06567 945713006058 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 945713006059 metal ion-dependent adhesion site (MIDAS); other site 945713006060 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 945713006061 Protein of unknown function DUF58; Region: DUF58; pfam01882 945713006062 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 945713006063 metal ion-dependent adhesion site (MIDAS); other site 945713006064 MoxR-like ATPases [General function prediction only]; Region: COG0714 945713006065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713006066 Walker A motif; other site 945713006067 ATP binding site [chemical binding]; other site 945713006068 Walker B motif; other site 945713006069 arginine finger; other site 945713006070 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006071 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 945713006072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713006073 motif II; other site 945713006074 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 945713006075 Peptidase family M23; Region: Peptidase_M23; pfam01551 945713006076 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 945713006077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006078 binding surface 945713006079 TPR motif; other site 945713006080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006081 binding surface 945713006082 TPR motif; other site 945713006083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006084 TPR motif; other site 945713006085 binding surface 945713006086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006087 binding surface 945713006088 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713006089 TPR motif; other site 945713006090 TPR repeat; Region: TPR_11; pfam13414 945713006091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006092 binding surface 945713006093 TPR motif; other site 945713006094 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 945713006095 transcription termination factor Rho; Provisional; Region: PRK12678 945713006096 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 945713006097 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 945713006098 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 945713006099 glutaminase active site [active] 945713006100 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 945713006101 dimer interface [polypeptide binding]; other site 945713006102 active site 945713006103 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 945713006104 dimer interface [polypeptide binding]; other site 945713006105 active site 945713006106 Propeptide_C25; Region: Propeptide_C25; pfam08126 945713006107 Peptidase family C25; Region: Peptidase_C25; pfam01364 945713006108 active site 945713006109 CARDB; Region: CARDB; pfam07705 945713006110 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713006111 Bacterial sugar transferase; Region: Bac_transf; pfam02397 945713006112 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 945713006113 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 945713006114 inhibitor-cofactor binding pocket; inhibition site 945713006115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713006116 catalytic residue [active] 945713006117 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 945713006118 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713006119 Ligand binding site; other site 945713006120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 945713006121 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 945713006122 active site 945713006123 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 945713006124 dimer interface [polypeptide binding]; other site 945713006125 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 945713006126 Ligand Binding Site [chemical binding]; other site 945713006127 Molecular Tunnel; other site 945713006128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713006129 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 945713006130 O-Antigen ligase; Region: Wzy_C; pfam04932 945713006131 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713006132 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713006133 putative active site [active] 945713006134 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 945713006135 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 945713006136 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945713006137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006138 S-adenosylmethionine binding site [chemical binding]; other site 945713006139 Chain length determinant protein; Region: Wzz; pfam02706 945713006140 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 945713006141 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 945713006142 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 945713006143 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 945713006144 SLBB domain; Region: SLBB; pfam10531 945713006145 SLBB domain; Region: SLBB; pfam10531 945713006146 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 945713006147 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 945713006148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713006149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006150 S-adenosylmethionine binding site [chemical binding]; other site 945713006151 recombination protein RecR; Reviewed; Region: recR; PRK00076 945713006152 RecR protein; Region: RecR; pfam02132 945713006153 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 945713006154 putative active site [active] 945713006155 putative metal-binding site [ion binding]; other site 945713006156 tetramer interface [polypeptide binding]; other site 945713006157 hypothetical protein; Validated; Region: PRK00153 945713006158 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 945713006159 active site 945713006160 substrate binding site [chemical binding]; other site 945713006161 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 945713006162 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 945713006163 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 945713006164 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 945713006165 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 945713006166 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 945713006167 putative active site [active] 945713006168 catalytic triad [active] 945713006169 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 945713006170 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 945713006171 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 945713006172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 945713006173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713006174 Coenzyme A binding pocket [chemical binding]; other site 945713006175 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 945713006176 CoA binding domain; Region: CoA_binding; smart00881 945713006177 CoA-ligase; Region: Ligase_CoA; pfam00549 945713006178 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 945713006179 active site 945713006180 multimer interface [polypeptide binding]; other site 945713006181 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 945713006182 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 945713006183 dimer interface [polypeptide binding]; other site 945713006184 active site residues [active] 945713006185 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 945713006186 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 945713006187 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 945713006188 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 945713006189 dimerization interface [polypeptide binding]; other site 945713006190 active site 945713006191 Preprotein translocase subunit; Region: YajC; pfam02699 945713006192 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 945713006193 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 945713006194 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 945713006195 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 945713006196 Domain of unknown function DUF21; Region: DUF21; pfam01595 945713006197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 945713006198 Transporter associated domain; Region: CorC_HlyC; smart01091 945713006199 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 945713006200 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 945713006201 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 945713006202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006203 ATP binding site [chemical binding]; other site 945713006204 Mg2+ binding site [ion binding]; other site 945713006205 G-X-G motif; other site 945713006206 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 945713006207 ATP binding site [chemical binding]; other site 945713006208 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 945713006209 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 945713006210 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 945713006211 folate binding site [chemical binding]; other site 945713006212 NADP+ binding site [chemical binding]; other site 945713006213 thymidylate synthase; Reviewed; Region: thyA; PRK01827 945713006214 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 945713006215 dimerization interface [polypeptide binding]; other site 945713006216 active site 945713006217 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006218 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 945713006219 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 945713006220 SLBB domain; Region: SLBB; pfam10531 945713006221 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 945713006222 NADH dehydrogenase subunit E; Validated; Region: PRK07539 945713006223 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 945713006224 putative dimer interface [polypeptide binding]; other site 945713006225 [2Fe-2S] cluster binding site [ion binding]; other site 945713006226 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713006227 four helix bundle protein; Region: TIGR02436 945713006228 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 945713006229 NADH dehydrogenase subunit D; Validated; Region: PRK06075 945713006230 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 945713006231 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 945713006232 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 945713006233 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 945713006234 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 945713006235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006236 ATP binding site [chemical binding]; other site 945713006237 Mg2+ binding site [ion binding]; other site 945713006238 G-X-G motif; other site 945713006239 malate dehydrogenase; Reviewed; Region: PRK06223 945713006240 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 945713006241 NAD(P) binding site [chemical binding]; other site 945713006242 dimer interface [polypeptide binding]; other site 945713006243 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945713006244 substrate binding site [chemical binding]; other site 945713006245 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 945713006246 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 945713006247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713006248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006249 dimer interface [polypeptide binding]; other site 945713006250 phosphorylation site [posttranslational modification] 945713006251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006252 ATP binding site [chemical binding]; other site 945713006253 Mg2+ binding site [ion binding]; other site 945713006254 G-X-G motif; other site 945713006255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713006256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713006257 active site 945713006258 phosphorylation site [posttranslational modification] 945713006259 intermolecular recognition site; other site 945713006260 dimerization interface [polypeptide binding]; other site 945713006261 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945713006262 DNA binding site [nucleotide binding] 945713006263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 945713006264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 945713006265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 945713006266 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 945713006267 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 945713006268 TPP-binding site; other site 945713006269 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945713006270 PYR/PP interface [polypeptide binding]; other site 945713006271 dimer interface [polypeptide binding]; other site 945713006272 TPP binding site [chemical binding]; other site 945713006273 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713006274 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 945713006275 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 945713006276 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 945713006277 generic binding surface II; other site 945713006278 generic binding surface I; other site 945713006279 hypothetical protein; Region: PHA00446 945713006280 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713006281 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713006282 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713006283 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 945713006284 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 945713006285 homodimer interface [polypeptide binding]; other site 945713006286 substrate-cofactor binding pocket; other site 945713006287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713006288 catalytic residue [active] 945713006289 four helix bundle protein; Region: TIGR02436 945713006290 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713006291 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 945713006292 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 945713006293 dimer interface [polypeptide binding]; other site 945713006294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713006295 catalytic residue [active] 945713006296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 945713006297 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 945713006298 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 945713006299 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 945713006300 dimer interface [polypeptide binding]; other site 945713006301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713006302 catalytic residue [active] 945713006303 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 945713006304 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 945713006305 putative active site [active] 945713006306 substrate binding site [chemical binding]; other site 945713006307 putative cosubstrate binding site; other site 945713006308 catalytic site [active] 945713006309 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 945713006310 substrate binding site [chemical binding]; other site 945713006311 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 945713006312 active site 945713006313 catalytic residues [active] 945713006314 metal binding site [ion binding]; metal-binding site 945713006315 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 945713006316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713006317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713006318 putative substrate translocation pore; other site 945713006319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713006320 putative substrate translocation pore; other site 945713006321 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 945713006322 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 945713006323 metal binding site [ion binding]; metal-binding site 945713006324 dimer interface [polypeptide binding]; other site 945713006325 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 945713006326 OPT oligopeptide transporter protein; Region: OPT; cl14607 945713006327 putative oligopeptide transporter, OPT family; Region: TIGR00733 945713006328 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713006329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006330 putative active site [active] 945713006331 heme pocket [chemical binding]; other site 945713006332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006333 dimer interface [polypeptide binding]; other site 945713006334 phosphorylation site [posttranslational modification] 945713006335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006336 ATP binding site [chemical binding]; other site 945713006337 Mg2+ binding site [ion binding]; other site 945713006338 G-X-G motif; other site 945713006339 Response regulator receiver domain; Region: Response_reg; pfam00072 945713006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713006341 active site 945713006342 phosphorylation site [posttranslational modification] 945713006343 intermolecular recognition site; other site 945713006344 dimerization interface [polypeptide binding]; other site 945713006345 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 945713006346 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006347 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713006348 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 945713006349 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713006350 N-terminal plug; other site 945713006351 ligand-binding site [chemical binding]; other site 945713006352 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713006353 BNR repeat-like domain; Region: BNR_2; pfam13088 945713006354 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 945713006355 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006356 Uncharacterized conserved protein [Function unknown]; Region: COG1284 945713006357 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 945713006358 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 945713006359 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 945713006360 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945713006361 active site 945713006362 AMP nucleosidase; Provisional; Region: PRK07115 945713006363 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 945713006364 Predicted GTPase [General function prediction only]; Region: COG2403 945713006365 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945713006366 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 945713006367 Na binding site [ion binding]; other site 945713006368 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 945713006369 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 945713006370 Na binding site [ion binding]; other site 945713006371 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006372 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006373 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 945713006374 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 945713006375 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 945713006376 transmembrane helices; other site 945713006377 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 945713006378 active site 945713006379 hydrophilic channel; other site 945713006380 dimerization interface [polypeptide binding]; other site 945713006381 catalytic residues [active] 945713006382 active site lid [active] 945713006383 CAAX protease self-immunity; Region: Abi; pfam02517 945713006384 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 945713006385 oligomerisation interface [polypeptide binding]; other site 945713006386 mobile loop; other site 945713006387 roof hairpin; other site 945713006388 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 945713006389 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 945713006390 ring oligomerisation interface [polypeptide binding]; other site 945713006391 ATP/Mg binding site [chemical binding]; other site 945713006392 stacking interactions; other site 945713006393 hinge regions; other site 945713006394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006395 binding surface 945713006396 TPR motif; other site 945713006397 CbbX; Provisional; Region: cbbX; CHL00181 945713006398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713006399 Walker A motif; other site 945713006400 ATP binding site [chemical binding]; other site 945713006401 Walker B motif; other site 945713006402 arginine finger; other site 945713006403 stage V sporulation protein K; Region: spore_V_K; TIGR02881 945713006404 stage V sporulation protein K; Region: spore_V_K; TIGR02881 945713006405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713006406 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 945713006407 active site 945713006408 metal binding site [ion binding]; metal-binding site 945713006409 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 945713006410 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 945713006411 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 945713006412 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 945713006413 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 945713006414 hexamer interface [polypeptide binding]; other site 945713006415 ligand binding site [chemical binding]; other site 945713006416 putative active site [active] 945713006417 NAD(P) binding site [chemical binding]; other site 945713006418 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 945713006419 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 945713006420 dimerization interface [polypeptide binding]; other site 945713006421 ligand binding site [chemical binding]; other site 945713006422 NADP binding site [chemical binding]; other site 945713006423 catalytic site [active] 945713006424 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 945713006425 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 945713006426 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 945713006427 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 945713006428 Family description; Region: UvrD_C_2; pfam13538 945713006429 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 945713006430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945713006431 dimerization interface [polypeptide binding]; other site 945713006432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006433 dimer interface [polypeptide binding]; other site 945713006434 phosphorylation site [posttranslational modification] 945713006435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006436 ATP binding site [chemical binding]; other site 945713006437 Mg2+ binding site [ion binding]; other site 945713006438 G-X-G motif; other site 945713006439 dihydroorotase; Validated; Region: pyrC; PRK09357 945713006440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 945713006441 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 945713006442 active site 945713006443 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 945713006444 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 945713006445 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 945713006446 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 945713006447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713006448 active site 945713006449 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713006450 GIY-YIG motif/motif A; other site 945713006451 putative active site [active] 945713006452 putative metal binding site [ion binding]; other site 945713006453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 945713006454 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 945713006455 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 945713006456 generic binding surface I; other site 945713006457 generic binding surface II; other site 945713006458 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 945713006459 cell division protein FtsZ; Validated; Region: PRK09330 945713006460 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 945713006461 nucleotide binding site [chemical binding]; other site 945713006462 SulA interaction site; other site 945713006463 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 945713006464 Cell division protein FtsA; Region: FtsA; smart00842 945713006465 Cell division protein FtsA; Region: FtsA; pfam14450 945713006466 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 945713006467 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 945713006468 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 945713006469 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 945713006470 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945713006471 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945713006472 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 945713006473 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 945713006474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945713006475 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945713006476 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 945713006477 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 945713006478 Mg++ binding site [ion binding]; other site 945713006479 putative catalytic motif [active] 945713006480 putative substrate binding site [chemical binding]; other site 945713006481 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 945713006482 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 945713006483 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945713006484 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945713006485 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 945713006486 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 945713006487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 945713006488 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 945713006489 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 945713006490 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 945713006491 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 945713006492 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 945713006493 MraW methylase family; Region: Methyltransf_5; cl17771 945713006494 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 945713006495 cell division protein MraZ; Reviewed; Region: PRK00326 945713006496 MraZ protein; Region: MraZ; pfam02381 945713006497 MraZ protein; Region: MraZ; pfam02381 945713006498 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 945713006499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006500 TPR motif; other site 945713006501 TPR repeat; Region: TPR_11; pfam13414 945713006502 binding surface 945713006503 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 945713006504 IHF dimer interface [polypeptide binding]; other site 945713006505 IHF - DNA interface [nucleotide binding]; other site 945713006506 Helix-turn-helix domain; Region: HTH_18; pfam12833 945713006507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 945713006508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945713006509 metal-binding site [ion binding] 945713006510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 945713006511 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 945713006512 metal-binding site [ion binding] 945713006513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 945713006514 Soluble P-type ATPase [General function prediction only]; Region: COG4087 945713006515 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 945713006516 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 945713006517 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 945713006518 active site 945713006519 oligoendopeptidase F; Region: pepF; TIGR00181 945713006520 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 945713006521 active site 945713006522 Zn binding site [ion binding]; other site 945713006523 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 945713006524 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 945713006525 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 945713006526 transmembrane helices; other site 945713006527 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 945713006528 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 945713006529 GatB domain; Region: GatB_Yqey; smart00845 945713006530 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945713006531 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 945713006532 Catalytic site [active] 945713006533 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945713006534 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713006535 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713006536 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 945713006537 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 945713006538 putative active site [active] 945713006539 putative metal binding site [ion binding]; other site 945713006540 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 945713006541 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 945713006542 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713006543 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713006544 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713006545 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 945713006546 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 945713006547 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 945713006548 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 945713006549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 945713006550 substrate binding site [chemical binding]; other site 945713006551 oxyanion hole (OAH) forming residues; other site 945713006552 trimer interface [polypeptide binding]; other site 945713006553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 945713006554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713006555 NAD(P) binding site [chemical binding]; other site 945713006556 active site 945713006557 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 945713006558 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 945713006559 dimerization interface 3.5A [polypeptide binding]; other site 945713006560 active site 945713006561 MgtC family; Region: MgtC; pfam02308 945713006562 Predicted membrane protein [Function unknown]; Region: COG3174 945713006563 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 945713006564 PAS domain; Region: PAS; smart00091 945713006565 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713006566 putative active site [active] 945713006567 heme pocket [chemical binding]; other site 945713006568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006569 putative active site [active] 945713006570 heme pocket [chemical binding]; other site 945713006571 PAS domain; Region: PAS_9; pfam13426 945713006572 PAS domain S-box; Region: sensory_box; TIGR00229 945713006573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006574 putative active site [active] 945713006575 heme pocket [chemical binding]; other site 945713006576 PAS domain; Region: PAS_9; pfam13426 945713006577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006578 putative active site [active] 945713006579 heme pocket [chemical binding]; other site 945713006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006581 putative active site [active] 945713006582 heme pocket [chemical binding]; other site 945713006583 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713006584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713006585 putative active site [active] 945713006586 heme pocket [chemical binding]; other site 945713006587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006588 dimer interface [polypeptide binding]; other site 945713006589 phosphorylation site [posttranslational modification] 945713006590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006591 ATP binding site [chemical binding]; other site 945713006592 G-X-G motif; other site 945713006593 Response regulator receiver domain; Region: Response_reg; pfam00072 945713006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713006595 active site 945713006596 phosphorylation site [posttranslational modification] 945713006597 intermolecular recognition site; other site 945713006598 dimerization interface [polypeptide binding]; other site 945713006599 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 945713006600 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 945713006601 NAD(P) binding site [chemical binding]; other site 945713006602 catalytic residues [active] 945713006603 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 945713006604 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 945713006605 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 945713006606 Mechanosensitive ion channel; Region: MS_channel; pfam00924 945713006607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713006608 active site 945713006609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006610 TPR motif; other site 945713006611 TPR repeat; Region: TPR_11; pfam13414 945713006612 binding surface 945713006613 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 945713006614 aromatic arch; other site 945713006615 DCoH dimer interaction site [polypeptide binding]; other site 945713006616 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 945713006617 DCoH tetramer interaction site [polypeptide binding]; other site 945713006618 substrate binding site [chemical binding]; other site 945713006619 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 945713006620 Clp amino terminal domain; Region: Clp_N; pfam02861 945713006621 Clp amino terminal domain; Region: Clp_N; pfam02861 945713006622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713006623 Walker A motif; other site 945713006624 ATP binding site [chemical binding]; other site 945713006625 Walker B motif; other site 945713006626 arginine finger; other site 945713006627 UvrB/uvrC motif; Region: UVR; pfam02151 945713006628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713006629 Walker A motif; other site 945713006630 ATP binding site [chemical binding]; other site 945713006631 Walker B motif; other site 945713006632 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 945713006633 hypothetical protein; Provisional; Region: PRK13665 945713006634 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 945713006635 Part of AAA domain; Region: AAA_19; pfam13245 945713006636 Family description; Region: UvrD_C_2; pfam13538 945713006637 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 945713006638 active site 945713006639 catalytic site [active] 945713006640 substrate binding site [chemical binding]; other site 945713006641 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945713006642 active site 945713006643 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 945713006644 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 945713006645 tetramer interface [polypeptide binding]; other site 945713006646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713006647 catalytic residue [active] 945713006648 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 945713006649 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 945713006650 putative active site [active] 945713006651 catalytic triad [active] 945713006652 putative dimer interface [polypeptide binding]; other site 945713006653 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 945713006654 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 945713006655 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 945713006656 homotrimer interaction site [polypeptide binding]; other site 945713006657 zinc binding site [ion binding]; other site 945713006658 CDP-binding sites; other site 945713006659 Acylphosphatase; Region: Acylphosphatase; pfam00708 945713006660 EamA-like transporter family; Region: EamA; pfam00892 945713006661 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 945713006662 EamA-like transporter family; Region: EamA; pfam00892 945713006663 GTPase Era; Reviewed; Region: era; PRK00089 945713006664 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 945713006665 G1 box; other site 945713006666 GTP/Mg2+ binding site [chemical binding]; other site 945713006667 Switch I region; other site 945713006668 G2 box; other site 945713006669 Switch II region; other site 945713006670 G3 box; other site 945713006671 G4 box; other site 945713006672 G5 box; other site 945713006673 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 945713006674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713006675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713006676 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 945713006677 4Fe-4S binding domain; Region: Fer4; pfam00037 945713006678 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 945713006679 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 945713006680 iron-sulfur cluster [ion binding]; other site 945713006681 [2Fe-2S] cluster binding site [ion binding]; other site 945713006682 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 945713006683 4Fe-4S binding domain; Region: Fer4; cl02805 945713006684 4Fe-4S binding domain; Region: Fer4; pfam00037 945713006685 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 945713006686 Repair protein; Region: Repair_PSII; pfam04536 945713006687 LemA family; Region: LemA; pfam04011 945713006688 Haemolytic domain; Region: Haemolytic; cl00506 945713006689 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 945713006690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 945713006691 active site 945713006692 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 945713006693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713006694 FeS/SAM binding site; other site 945713006695 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 945713006696 Divergent AAA domain; Region: AAA_4; pfam04326 945713006697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 945713006698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713006699 binding surface 945713006700 TPR motif; other site 945713006701 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 945713006702 Nitrogen regulatory protein P-II; Region: P-II; smart00938 945713006703 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 945713006704 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 945713006705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713006706 nucleotide binding region [chemical binding]; other site 945713006707 ATP-binding site [chemical binding]; other site 945713006708 SEC-C motif; Region: SEC-C; pfam02810 945713006709 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 945713006710 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713006711 putative catalytic residue [active] 945713006712 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 945713006713 putative active site [active] 945713006714 Zn binding site [ion binding]; other site 945713006715 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 945713006716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713006717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713006718 DNA binding residues [nucleotide binding] 945713006719 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 945713006720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945713006721 Ligand Binding Site [chemical binding]; other site 945713006722 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 945713006723 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 945713006724 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 945713006725 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 945713006726 Preprotein translocase SecG subunit; Region: SecG; cl09123 945713006727 GTPase CgtA; Reviewed; Region: obgE; PRK12299 945713006728 GTP1/OBG; Region: GTP1_OBG; pfam01018 945713006729 Obg GTPase; Region: Obg; cd01898 945713006730 G1 box; other site 945713006731 GTP/Mg2+ binding site [chemical binding]; other site 945713006732 Switch I region; other site 945713006733 G2 box; other site 945713006734 G3 box; other site 945713006735 Switch II region; other site 945713006736 G4 box; other site 945713006737 G5 box; other site 945713006738 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 945713006739 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 945713006740 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 945713006741 L-aspartate oxidase; Provisional; Region: PRK06175 945713006742 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 945713006743 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 945713006744 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 945713006745 putative Iron-sulfur protein interface [polypeptide binding]; other site 945713006746 proximal heme binding site [chemical binding]; other site 945713006747 distal heme binding site [chemical binding]; other site 945713006748 putative dimer interface [polypeptide binding]; other site 945713006749 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 945713006750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713006751 N-terminal plug; other site 945713006752 ligand-binding site [chemical binding]; other site 945713006753 Uncharacterized conserved protein [Function unknown]; Region: COG3391 945713006754 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006755 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 945713006756 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 945713006757 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 945713006758 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 945713006759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 945713006760 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 945713006761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713006762 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 945713006763 putative active site [active] 945713006764 Isochorismatase family; Region: Isochorismatase; pfam00857 945713006765 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 945713006766 catalytic triad [active] 945713006767 dimer interface [polypeptide binding]; other site 945713006768 conserved cis-peptide bond; other site 945713006769 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 945713006770 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006771 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 945713006772 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 945713006773 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 945713006774 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 945713006775 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006776 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006777 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713006778 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713006779 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006780 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006781 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 945713006782 trimer interface [polypeptide binding]; other site 945713006783 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 945713006784 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 945713006785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 945713006786 Kelch motif; Region: Kelch_1; pfam01344 945713006787 Galactose oxidase, central domain; Region: Kelch_3; cl02701 945713006788 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006789 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006790 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 945713006791 Two component regulator propeller; Region: Reg_prop; pfam07494 945713006792 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 945713006793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713006794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713006795 dimer interface [polypeptide binding]; other site 945713006796 phosphorylation site [posttranslational modification] 945713006797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713006798 ATP binding site [chemical binding]; other site 945713006799 Mg2+ binding site [ion binding]; other site 945713006800 G-X-G motif; other site 945713006801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713006802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713006803 active site 945713006804 phosphorylation site [posttranslational modification] 945713006805 intermolecular recognition site; other site 945713006806 dimerization interface [polypeptide binding]; other site 945713006807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 945713006808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 945713006809 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945713006810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713006811 Peptidase family M1; Region: Peptidase_M1; pfam01433 945713006812 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 945713006813 Zn binding site [ion binding]; other site 945713006814 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006815 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 945713006816 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 945713006817 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 945713006818 putative active site [active] 945713006819 putative metal binding residues [ion binding]; other site 945713006820 signature motif; other site 945713006821 putative triphosphate binding site [ion binding]; other site 945713006822 dimer interface [polypeptide binding]; other site 945713006823 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 945713006824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006825 S-adenosylmethionine binding site [chemical binding]; other site 945713006826 OmpW family; Region: OmpW; cl17427 945713006827 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006828 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006829 putative transposase OrfB; Reviewed; Region: PHA02517 945713006830 Homeodomain-like domain; Region: HTH_32; pfam13565 945713006831 Integrase core domain; Region: rve; pfam00665 945713006832 Integrase core domain; Region: rve_3; pfam13683 945713006833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713006834 Transposase; Region: HTH_Tnp_1; pfam01527 945713006835 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 945713006836 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006837 putative transposase OrfB; Reviewed; Region: PHA02517 945713006838 Homeodomain-like domain; Region: HTH_32; pfam13565 945713006839 Integrase core domain; Region: rve; pfam00665 945713006840 Integrase core domain; Region: rve_3; pfam13683 945713006841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 945713006842 Transposase; Region: HTH_Tnp_1; pfam01527 945713006843 Family description; Region: VCBS; pfam13517 945713006844 Family description; Region: VCBS; pfam13517 945713006845 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713006846 PEGA domain; Region: PEGA; pfam08308 945713006847 integron integrase; Region: integrase_gron; TIGR02249 945713006848 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 945713006849 Int/Topo IB signature motif; other site 945713006850 OmpW family; Region: OmpW; cl17427 945713006851 SurA N-terminal domain; Region: SurA_N_3; cl07813 945713006852 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 945713006853 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 945713006854 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 945713006855 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713006856 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713006857 ligand binding site [chemical binding]; other site 945713006858 flexible hinge region; other site 945713006859 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 945713006860 putative switch regulator; other site 945713006861 non-specific DNA interactions [nucleotide binding]; other site 945713006862 DNA binding site [nucleotide binding] 945713006863 sequence specific DNA binding site [nucleotide binding]; other site 945713006864 putative cAMP binding site [chemical binding]; other site 945713006865 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 945713006866 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 945713006867 active site 945713006868 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 945713006869 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 945713006870 homopentamer interface [polypeptide binding]; other site 945713006871 active site 945713006872 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713006873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 945713006874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945713006875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713006876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945713006877 ABC transporter signature motif; other site 945713006878 Walker B; other site 945713006879 D-loop; other site 945713006880 ABC transporter; Region: ABC_tran_2; pfam12848 945713006881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 945713006882 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 945713006883 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 945713006884 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713006885 nucleotide binding site [chemical binding]; other site 945713006886 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 945713006887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006888 S-adenosylmethionine binding site [chemical binding]; other site 945713006889 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 945713006890 active site 945713006891 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 945713006892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006893 S-adenosylmethionine binding site [chemical binding]; other site 945713006894 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 945713006895 active site 945713006896 dimerization interface [polypeptide binding]; other site 945713006897 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 945713006898 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 945713006899 active site 945713006900 putative substrate binding pocket [chemical binding]; other site 945713006901 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 945713006902 Rhomboid family; Region: Rhomboid; pfam01694 945713006903 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 945713006904 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 945713006905 Uncharacterized conserved protein [Function unknown]; Region: COG3342 945713006906 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 945713006907 TPR repeat; Region: TPR_11; pfam13414 945713006908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713006909 TPR motif; other site 945713006910 Predicted acyl esterases [General function prediction only]; Region: COG2936 945713006911 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713006912 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 945713006913 hypothetical protein; Provisional; Region: PRK10621 945713006914 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 945713006915 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945713006916 active site 945713006917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945713006918 catalytic tetrad [active] 945713006919 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 945713006920 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945713006921 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 945713006922 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 945713006923 Uncharacterized conserved protein [Function unknown]; Region: COG1739 945713006924 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 945713006925 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 945713006926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 945713006927 MarR family; Region: MarR; pfam01047 945713006928 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 945713006929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713006930 S-adenosylmethionine binding site [chemical binding]; other site 945713006931 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945713006932 active site 945713006933 catalytic residues [active] 945713006934 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713006935 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 945713006936 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945713006937 Catalytic site [active] 945713006938 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 945713006939 Catalytic site [active] 945713006940 GTP-binding protein LepA; Provisional; Region: PRK05433 945713006941 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 945713006942 G1 box; other site 945713006943 putative GEF interaction site [polypeptide binding]; other site 945713006944 GTP/Mg2+ binding site [chemical binding]; other site 945713006945 Switch I region; other site 945713006946 G2 box; other site 945713006947 G3 box; other site 945713006948 Switch II region; other site 945713006949 G4 box; other site 945713006950 G5 box; other site 945713006951 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 945713006952 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 945713006953 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 945713006954 exopolyphosphatase; Region: exo_poly_only; TIGR03706 945713006955 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 945713006956 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713006957 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713006958 putative active site [active] 945713006959 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 945713006960 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 945713006961 Substrate-binding site [chemical binding]; other site 945713006962 Substrate specificity [chemical binding]; other site 945713006963 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 945713006964 catalytic center binding site [active] 945713006965 ATP binding site [chemical binding]; other site 945713006966 Dihydroneopterin aldolase; Region: FolB; pfam02152 945713006967 active site 945713006968 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 945713006969 EamA-like transporter family; Region: EamA; pfam00892 945713006970 EamA-like transporter family; Region: EamA; pfam00892 945713006971 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 945713006972 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 945713006973 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 945713006974 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 945713006975 CARDB; Region: CARDB; pfam07705 945713006976 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 945713006977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713006978 active site 945713006979 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 945713006980 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 945713006981 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 945713006982 active site 945713006983 HIGH motif; other site 945713006984 KMSK motif region; other site 945713006985 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 945713006986 tRNA binding surface [nucleotide binding]; other site 945713006987 anticodon binding site; other site 945713006988 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 945713006989 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 945713006990 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 945713006991 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 945713006992 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 945713006993 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 945713006994 Glutamine amidotransferase class-I; Region: GATase; pfam00117 945713006995 glutamine binding [chemical binding]; other site 945713006996 catalytic triad [active] 945713006997 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 945713006998 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 945713006999 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 945713007000 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 945713007001 active site 945713007002 ribulose/triose binding site [chemical binding]; other site 945713007003 phosphate binding site [ion binding]; other site 945713007004 substrate (anthranilate) binding pocket [chemical binding]; other site 945713007005 product (indole) binding pocket [chemical binding]; other site 945713007006 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 945713007007 active site 945713007008 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 945713007009 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 945713007010 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 945713007011 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 945713007012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713007013 catalytic residue [active] 945713007014 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 945713007015 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 945713007016 substrate binding site [chemical binding]; other site 945713007017 active site 945713007018 catalytic residues [active] 945713007019 heterodimer interface [polypeptide binding]; other site 945713007020 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713007021 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 945713007022 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945713007023 metal binding triad; other site 945713007024 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 945713007025 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 945713007026 metal binding triad; other site 945713007027 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 945713007028 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 945713007029 FtsH Extracellular; Region: FtsH_ext; pfam06480 945713007030 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 945713007031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713007032 Walker B motif; other site 945713007033 arginine finger; other site 945713007034 Peptidase family M41; Region: Peptidase_M41; pfam01434 945713007035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 945713007036 active site 945713007037 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 945713007038 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 945713007039 Ligand Binding Site [chemical binding]; other site 945713007040 TilS substrate C-terminal domain; Region: TilS_C; smart00977 945713007041 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 945713007042 Lumazine binding domain; Region: Lum_binding; pfam00677 945713007043 Lumazine binding domain; Region: Lum_binding; pfam00677 945713007044 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 945713007045 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 945713007046 catalytic motif [active] 945713007047 Zn binding site [ion binding]; other site 945713007048 RibD C-terminal domain; Region: RibD_C; cl17279 945713007049 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 945713007050 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 945713007051 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 945713007052 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 945713007053 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 945713007054 metal binding triad [ion binding]; metal-binding site 945713007055 Protein of unknown function DUF86; Region: DUF86; cl01031 945713007056 Protein of unknown function DUF86; Region: DUF86; cl01031 945713007057 tyrosine decarboxylase; Region: PLN02880 945713007058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 945713007059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713007060 catalytic residue [active] 945713007061 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 945713007062 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 945713007063 Cu(I) binding site [ion binding]; other site 945713007064 GxxExxY protein; Region: GxxExxY; TIGR04256 945713007065 Protein of unknown function (DUF461); Region: DUF461; pfam04314 945713007066 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007067 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 945713007068 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007069 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007070 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 945713007071 lipoyl-biotinyl attachment site [posttranslational modification]; other site 945713007072 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713007073 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 945713007074 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 945713007075 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 945713007076 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 945713007077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945713007078 dimerization interface [polypeptide binding]; other site 945713007079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713007080 dimer interface [polypeptide binding]; other site 945713007081 phosphorylation site [posttranslational modification] 945713007082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007083 ATP binding site [chemical binding]; other site 945713007084 Mg2+ binding site [ion binding]; other site 945713007085 G-X-G motif; other site 945713007086 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713007087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007088 active site 945713007089 phosphorylation site [posttranslational modification] 945713007090 intermolecular recognition site; other site 945713007091 dimerization interface [polypeptide binding]; other site 945713007092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713007093 Walker A motif; other site 945713007094 ATP binding site [chemical binding]; other site 945713007095 Walker B motif; other site 945713007096 arginine finger; other site 945713007097 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713007098 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 945713007099 active site 945713007100 Zn binding site [ion binding]; other site 945713007101 Peptidase family M48; Region: Peptidase_M48; cl12018 945713007102 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 945713007103 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 945713007104 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 945713007105 Predicted membrane protein [Function unknown]; Region: COG3212 945713007106 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 945713007107 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 945713007108 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 945713007109 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 945713007110 heterodimer interface [polypeptide binding]; other site 945713007111 substrate interaction site [chemical binding]; other site 945713007112 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713007113 B12 binding site [chemical binding]; other site 945713007114 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713007115 four helix bundle protein; Region: TIGR02436 945713007116 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 945713007117 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 945713007118 active site 945713007119 substrate binding site [chemical binding]; other site 945713007120 coenzyme B12 binding site [chemical binding]; other site 945713007121 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 945713007122 B12 binding site [chemical binding]; other site 945713007123 cobalt ligand [ion binding]; other site 945713007124 membrane ATPase/protein kinase; Provisional; Region: PRK09435 945713007125 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 945713007126 Walker A; other site 945713007127 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713007128 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713007129 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713007130 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713007131 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713007132 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713007133 ligand binding site [chemical binding]; other site 945713007134 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713007135 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 945713007136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713007137 ligand binding site [chemical binding]; other site 945713007138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 945713007139 putative trimer interface [polypeptide binding]; other site 945713007140 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 945713007141 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 945713007142 putative trimer interface [polypeptide binding]; other site 945713007143 putative active site [active] 945713007144 putative substrate binding site [chemical binding]; other site 945713007145 putative CoA binding site [chemical binding]; other site 945713007146 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 945713007147 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 945713007148 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 945713007149 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 945713007150 Bacterial sugar transferase; Region: Bac_transf; pfam02397 945713007151 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 945713007152 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 945713007153 inhibitor-cofactor binding pocket; inhibition site 945713007154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713007155 catalytic residue [active] 945713007156 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 945713007157 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 945713007158 Chain length determinant protein; Region: Wzz; pfam02706 945713007159 tyrosine kinase; Provisional; Region: PRK11519 945713007160 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 945713007161 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945713007162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 945713007163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 945713007164 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713007165 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 945713007166 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 945713007167 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 945713007168 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 945713007169 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 945713007170 putative trimer interface [polypeptide binding]; other site 945713007171 putative active site [active] 945713007172 putative substrate binding site [chemical binding]; other site 945713007173 putative CoA binding site [chemical binding]; other site 945713007174 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 945713007175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713007176 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 945713007177 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 945713007178 NADP-binding site; other site 945713007179 homotetramer interface [polypeptide binding]; other site 945713007180 substrate binding site [chemical binding]; other site 945713007181 homodimer interface [polypeptide binding]; other site 945713007182 active site 945713007183 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 945713007184 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 945713007185 NADP-binding site; other site 945713007186 homotetramer interface [polypeptide binding]; other site 945713007187 substrate binding site [chemical binding]; other site 945713007188 homodimer interface [polypeptide binding]; other site 945713007189 active site 945713007190 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713007191 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 945713007192 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713007193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 945713007194 active site 945713007195 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 945713007196 O-Antigen ligase; Region: Wzy_C; pfam04932 945713007197 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 945713007198 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 945713007199 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007200 Domain of unknown function (DUF955); Region: DUF955; cl01076 945713007201 FemAB family; Region: FemAB; pfam02388 945713007202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 945713007203 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 945713007204 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 945713007205 catalytic triad [active] 945713007206 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713007207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 945713007208 active site 945713007209 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 945713007210 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 945713007211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 945713007212 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 945713007213 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 945713007214 acyl-activating enzyme (AAE) consensus motif; other site 945713007215 AMP binding site [chemical binding]; other site 945713007216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 945713007217 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 945713007218 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 945713007219 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 945713007220 acyl-activating enzyme (AAE) consensus motif; other site 945713007221 AMP binding site [chemical binding]; other site 945713007222 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 945713007223 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 945713007224 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 945713007225 active site 945713007226 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 945713007227 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 945713007228 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 945713007229 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 945713007230 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945713007231 inhibitor-cofactor binding pocket; inhibition site 945713007232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713007233 catalytic residue [active] 945713007234 Condensation domain; Region: Condensation; pfam00668 945713007235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 945713007236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 945713007237 Cupin-like domain; Region: Cupin_8; pfam13621 945713007238 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 945713007239 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 945713007240 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 945713007241 trimer interface [polypeptide binding]; other site 945713007242 active site 945713007243 substrate binding site [chemical binding]; other site 945713007244 CoA binding site [chemical binding]; other site 945713007245 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 945713007246 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 945713007247 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 945713007248 active site 945713007249 dimer interface [polypeptide binding]; other site 945713007250 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 945713007251 Ligand Binding Site [chemical binding]; other site 945713007252 Molecular Tunnel; other site 945713007253 NAD synthetase; Reviewed; Region: nadE; PRK00876 945713007254 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 945713007255 Ligand Binding Site [chemical binding]; other site 945713007256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945713007257 AMP-binding enzyme; Region: AMP-binding; pfam00501 945713007258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 945713007259 acyl-activating enzyme (AAE) consensus motif; other site 945713007260 acyl-activating enzyme (AAE) consensus motif; other site 945713007261 AMP binding site [chemical binding]; other site 945713007262 active site 945713007263 CoA binding site [chemical binding]; other site 945713007264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007265 PAS fold; Region: PAS_3; pfam08447 945713007266 putative active site [active] 945713007267 heme pocket [chemical binding]; other site 945713007268 PAS domain S-box; Region: sensory_box; TIGR00229 945713007269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007270 putative active site [active] 945713007271 heme pocket [chemical binding]; other site 945713007272 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 945713007273 GAF domain; Region: GAF; pfam01590 945713007274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007275 PAS domain; Region: PAS_9; pfam13426 945713007276 putative active site [active] 945713007277 heme pocket [chemical binding]; other site 945713007278 PAS domain S-box; Region: sensory_box; TIGR00229 945713007279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007280 putative active site [active] 945713007281 heme pocket [chemical binding]; other site 945713007282 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 945713007283 PAS domain S-box; Region: sensory_box; TIGR00229 945713007284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007285 putative active site [active] 945713007286 heme pocket [chemical binding]; other site 945713007287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945713007288 Histidine kinase; Region: HisKA_3; pfam07730 945713007289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007290 ATP binding site [chemical binding]; other site 945713007291 Mg2+ binding site [ion binding]; other site 945713007292 G-X-G motif; other site 945713007293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713007294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007295 active site 945713007296 phosphorylation site [posttranslational modification] 945713007297 intermolecular recognition site; other site 945713007298 dimerization interface [polypeptide binding]; other site 945713007299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713007300 DNA binding residues [nucleotide binding] 945713007301 dimerization interface [polypeptide binding]; other site 945713007302 PAS domain; Region: PAS_9; pfam13426 945713007303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007304 putative active site [active] 945713007305 heme pocket [chemical binding]; other site 945713007306 PAS fold; Region: PAS_3; pfam08447 945713007307 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 945713007308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713007309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713007310 dimer interface [polypeptide binding]; other site 945713007311 phosphorylation site [posttranslational modification] 945713007312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007313 ATP binding site [chemical binding]; other site 945713007314 Mg2+ binding site [ion binding]; other site 945713007315 G-X-G motif; other site 945713007316 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713007317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007318 active site 945713007319 phosphorylation site [posttranslational modification] 945713007320 intermolecular recognition site; other site 945713007321 dimerization interface [polypeptide binding]; other site 945713007322 PAS domain; Region: PAS_9; pfam13426 945713007323 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 945713007324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 945713007325 putative active site [active] 945713007326 heme pocket [chemical binding]; other site 945713007327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713007328 dimer interface [polypeptide binding]; other site 945713007329 phosphorylation site [posttranslational modification] 945713007330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007331 ATP binding site [chemical binding]; other site 945713007332 Mg2+ binding site [ion binding]; other site 945713007333 G-X-G motif; other site 945713007334 Response regulator receiver domain; Region: Response_reg; pfam00072 945713007335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007336 active site 945713007337 phosphorylation site [posttranslational modification] 945713007338 intermolecular recognition site; other site 945713007339 dimerization interface [polypeptide binding]; other site 945713007340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 945713007341 dimer interface [polypeptide binding]; other site 945713007342 phosphorylation site [posttranslational modification] 945713007343 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713007344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007345 active site 945713007346 phosphorylation site [posttranslational modification] 945713007347 intermolecular recognition site; other site 945713007348 dimerization interface [polypeptide binding]; other site 945713007349 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 945713007350 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 945713007351 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713007352 ligand binding site [chemical binding]; other site 945713007353 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 945713007354 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 945713007355 Response regulator receiver domain; Region: Response_reg; pfam00072 945713007356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007357 active site 945713007358 phosphorylation site [posttranslational modification] 945713007359 intermolecular recognition site; other site 945713007360 dimerization interface [polypeptide binding]; other site 945713007361 Hpt domain; Region: Hpt; pfam01627 945713007362 Global regulator protein family; Region: CsrA; pfam02599 945713007363 FliW protein; Region: FliW; cl00740 945713007364 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 945713007365 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 945713007366 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 945713007367 ligand binding site [chemical binding]; other site 945713007368 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 945713007369 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 945713007370 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 945713007371 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 945713007372 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 945713007373 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 945713007374 FlgN protein; Region: FlgN; pfam05130 945713007375 Rod binding protein; Region: Rod-binding; pfam10135 945713007376 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 945713007377 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 945713007378 N-acetyl-D-glucosamine binding site [chemical binding]; other site 945713007379 catalytic residue [active] 945713007380 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 945713007381 Flagellar P-ring protein; Region: FlgI; pfam02119 945713007382 Flagellar L-ring protein; Region: FlgH; pfam02107 945713007383 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 945713007384 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 945713007385 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 945713007386 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 945713007387 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 945713007388 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 945713007389 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 945713007390 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 945713007391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713007392 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 945713007393 HDOD domain; Region: HDOD; pfam08668 945713007394 HD domain; Region: HD; pfam01966 945713007395 HDOD domain; Region: HDOD; pfam08668 945713007396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713007397 Zn2+ binding site [ion binding]; other site 945713007398 Mg2+ binding site [ion binding]; other site 945713007399 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 945713007400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713007401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713007402 DNA binding residues [nucleotide binding] 945713007403 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 945713007404 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 945713007405 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 945713007406 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 945713007407 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 945713007408 FHIPEP family; Region: FHIPEP; pfam00771 945713007409 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 945713007410 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 945713007411 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 945713007412 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 945713007413 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 945713007414 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 945713007415 flagellar motor switch protein FliN; Region: fliN; TIGR02480 945713007416 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 945713007417 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 945713007418 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 945713007419 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 945713007420 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 945713007421 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 945713007422 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 945713007423 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 945713007424 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 945713007425 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 945713007426 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 945713007427 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713007428 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 945713007429 Uncharacterized conserved protein [Function unknown]; Region: COG3334 945713007430 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 945713007431 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 945713007432 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 945713007433 Walker A motif/ATP binding site; other site 945713007434 Walker B motif; other site 945713007435 Flagellar assembly protein FliH; Region: FliH; pfam02108 945713007436 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 945713007437 FliG C-terminal domain; Region: FliG_C; pfam01706 945713007438 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 945713007439 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 945713007440 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 945713007441 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 945713007442 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 945713007443 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 945713007444 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 945713007445 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 945713007446 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 945713007447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007448 active site 945713007449 phosphorylation site [posttranslational modification] 945713007450 intermolecular recognition site; other site 945713007451 dimerization interface [polypeptide binding]; other site 945713007452 CheB methylesterase; Region: CheB_methylest; pfam01339 945713007453 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 945713007454 putative binding surface; other site 945713007455 active site 945713007456 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 945713007457 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 945713007458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007459 ATP binding site [chemical binding]; other site 945713007460 Mg2+ binding site [ion binding]; other site 945713007461 G-X-G motif; other site 945713007462 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 945713007463 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 945713007464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007465 active site 945713007466 phosphorylation site [posttranslational modification] 945713007467 intermolecular recognition site; other site 945713007468 dimerization interface [polypeptide binding]; other site 945713007469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007470 Response regulator receiver domain; Region: Response_reg; pfam00072 945713007471 active site 945713007472 phosphorylation site [posttranslational modification] 945713007473 intermolecular recognition site; other site 945713007474 dimerization interface [polypeptide binding]; other site 945713007475 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 945713007476 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 945713007477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007478 HEAT repeats; Region: HEAT_2; pfam13646 945713007479 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 945713007480 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 945713007481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 945713007482 dimerization interface [polypeptide binding]; other site 945713007483 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 945713007484 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 945713007485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 945713007486 dimer interface [polypeptide binding]; other site 945713007487 putative CheW interface [polypeptide binding]; other site 945713007488 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 945713007489 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 945713007490 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 945713007491 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713007492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007493 active site 945713007494 phosphorylation site [posttranslational modification] 945713007495 intermolecular recognition site; other site 945713007496 dimerization interface [polypeptide binding]; other site 945713007497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713007498 Walker A motif; other site 945713007499 ATP binding site [chemical binding]; other site 945713007500 Walker B motif; other site 945713007501 arginine finger; other site 945713007502 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713007503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007504 ATP binding site [chemical binding]; other site 945713007505 Mg2+ binding site [ion binding]; other site 945713007506 G-X-G motif; other site 945713007507 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 945713007508 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 945713007509 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 945713007510 Flagellar protein FliS; Region: FliS; cl00654 945713007511 flagellin; Provisional; Region: PRK12802 945713007512 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 945713007513 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 945713007514 phosphodiesterase; Provisional; Region: PRK12704 945713007515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713007516 active site 945713007517 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 945713007518 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 945713007519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007520 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713007521 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713007522 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 945713007523 Probable Catalytic site; other site 945713007524 metal-binding site 945713007525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713007526 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 945713007527 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713007528 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 945713007529 Probable Catalytic site; other site 945713007530 metal-binding site 945713007531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713007532 binding surface 945713007533 TPR motif; other site 945713007534 TPR repeat; Region: TPR_11; pfam13414 945713007535 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713007536 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 945713007537 putative metal binding site; other site 945713007538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713007539 binding surface 945713007540 TPR motif; other site 945713007541 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713007542 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713007543 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713007544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 945713007545 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 945713007546 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 945713007547 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 945713007548 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 945713007549 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 945713007550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 945713007551 catalytic loop [active] 945713007552 iron binding site [ion binding]; other site 945713007553 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 945713007554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 945713007555 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 945713007556 active site 945713007557 catalytic tetrad [active] 945713007558 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 945713007559 Na binding site [ion binding]; other site 945713007560 CotH protein; Region: CotH; pfam08757 945713007561 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007562 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 945713007563 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 945713007564 putative metal binding site [ion binding]; other site 945713007565 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007566 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 945713007567 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 945713007568 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 945713007569 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 945713007570 active site 945713007571 catalytic residues [active] 945713007572 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 945713007573 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713007574 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713007575 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713007576 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 945713007577 putative ligand binding site [chemical binding]; other site 945713007578 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007579 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 945713007580 Na binding site [ion binding]; other site 945713007581 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 945713007582 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 945713007583 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 945713007584 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007585 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713007586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007587 active site 945713007588 phosphorylation site [posttranslational modification] 945713007589 intermolecular recognition site; other site 945713007590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713007591 Walker A motif; other site 945713007592 ATP binding site [chemical binding]; other site 945713007593 Walker B motif; other site 945713007594 arginine finger; other site 945713007595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713007596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007597 ATP binding site [chemical binding]; other site 945713007598 Mg2+ binding site [ion binding]; other site 945713007599 G-X-G motif; other site 945713007600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 945713007601 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 945713007602 Transposase domain (DUF772); Region: DUF772; pfam05598 945713007603 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713007604 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713007605 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713007606 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 945713007607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713007608 putative substrate translocation pore; other site 945713007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713007610 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 945713007611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 945713007612 nucleotide binding site [chemical binding]; other site 945713007613 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 945713007614 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 945713007615 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 945713007616 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 945713007617 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 945713007618 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 945713007619 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 945713007620 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 945713007621 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007622 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 945713007623 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713007624 GIY-YIG motif/motif A; other site 945713007625 putative active site [active] 945713007626 putative metal binding site [ion binding]; other site 945713007627 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713007628 GIY-YIG motif/motif A; other site 945713007629 putative active site [active] 945713007630 putative metal binding site [ion binding]; other site 945713007631 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713007632 GIY-YIG motif/motif A; other site 945713007633 putative active site [active] 945713007634 putative metal binding site [ion binding]; other site 945713007635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007636 Response regulator receiver domain; Region: Response_reg; pfam00072 945713007637 active site 945713007638 phosphorylation site [posttranslational modification] 945713007639 intermolecular recognition site; other site 945713007640 dimerization interface [polypeptide binding]; other site 945713007641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713007642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007643 active site 945713007644 phosphorylation site [posttranslational modification] 945713007645 intermolecular recognition site; other site 945713007646 dimerization interface [polypeptide binding]; other site 945713007647 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713007648 DNA binding residues [nucleotide binding] 945713007649 dimerization interface [polypeptide binding]; other site 945713007650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007651 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713007652 putative active site [active] 945713007653 heme pocket [chemical binding]; other site 945713007654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007655 putative active site [active] 945713007656 heme pocket [chemical binding]; other site 945713007657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007658 PAS domain; Region: PAS_9; pfam13426 945713007659 putative active site [active] 945713007660 heme pocket [chemical binding]; other site 945713007661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 945713007662 Histidine kinase; Region: HisKA_3; pfam07730 945713007663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007664 ATP binding site [chemical binding]; other site 945713007665 Mg2+ binding site [ion binding]; other site 945713007666 G-X-G motif; other site 945713007667 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 945713007668 EamA-like transporter family; Region: EamA; pfam00892 945713007669 Peptidase S46; Region: Peptidase_S46; pfam10459 945713007670 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713007671 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713007672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 945713007673 TPR motif; other site 945713007674 binding surface 945713007675 glycyl-tRNA synthetase; Provisional; Region: PRK04173 945713007676 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945713007677 motif 1; other site 945713007678 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 945713007679 active site 945713007680 motif 2; other site 945713007681 motif 3; other site 945713007682 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 945713007683 anticodon binding site; other site 945713007684 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 945713007685 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 945713007686 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 945713007687 putative ligand binding pocket/active site [active] 945713007688 putative metal binding site [ion binding]; other site 945713007689 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 945713007690 AMMECR1; Region: AMMECR1; pfam01871 945713007691 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 945713007692 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 945713007693 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 945713007694 substrate binding site [chemical binding]; other site 945713007695 tetramer interface [polypeptide binding]; other site 945713007696 catalytic residue [active] 945713007697 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 945713007698 Helix-turn-helix domain; Region: HTH_20; pfam12840 945713007699 primosome assembly protein PriA; Validated; Region: PRK05580 945713007700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713007701 ATP binding site [chemical binding]; other site 945713007702 putative Mg++ binding site [ion binding]; other site 945713007703 helicase superfamily c-terminal domain; Region: HELICc; smart00490 945713007704 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 945713007705 dimer interface [polypeptide binding]; other site 945713007706 catalytic triad [active] 945713007707 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 945713007708 CoA binding domain; Region: CoA_binding_2; pfam13380 945713007709 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 945713007710 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 945713007711 Domain of unknown function (DUF897); Region: DUF897; pfam05982 945713007712 Nitrogen regulatory protein P-II; Region: P-II; cl00412 945713007713 Peptidase S46; Region: Peptidase_S46; pfam10459 945713007714 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713007715 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713007716 multidrug efflux system protein; Provisional; Region: PRK11431 945713007717 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 945713007718 DNA methylase; Region: N6_N4_Mtase; pfam01555 945713007719 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 945713007720 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 945713007721 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 945713007722 catalytic nucleophile [active] 945713007723 DinB superfamily; Region: DinB_2; pfam12867 945713007724 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 945713007725 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 945713007726 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713007727 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713007728 putative active site [active] 945713007729 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 945713007730 AMP binding site [chemical binding]; other site 945713007731 metal binding site [ion binding]; metal-binding site 945713007732 active site 945713007733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 945713007734 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945713007735 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 945713007736 Walker A/P-loop; other site 945713007737 ATP binding site [chemical binding]; other site 945713007738 Q-loop/lid; other site 945713007739 ABC transporter signature motif; other site 945713007740 Walker B; other site 945713007741 D-loop; other site 945713007742 H-loop/switch region; other site 945713007743 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 945713007744 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 945713007745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713007746 Walker A/P-loop; other site 945713007747 ATP binding site [chemical binding]; other site 945713007748 Q-loop/lid; other site 945713007749 ABC transporter signature motif; other site 945713007750 Walker B; other site 945713007751 D-loop; other site 945713007752 H-loop/switch region; other site 945713007753 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 945713007754 seryl-tRNA synthetase; Provisional; Region: PRK05431 945713007755 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 945713007756 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 945713007757 dimer interface [polypeptide binding]; other site 945713007758 active site 945713007759 motif 1; other site 945713007760 motif 2; other site 945713007761 motif 3; other site 945713007762 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 945713007763 active site 945713007764 NTP binding site [chemical binding]; other site 945713007765 metal binding triad [ion binding]; metal-binding site 945713007766 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 945713007767 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 945713007768 HIGH motif; other site 945713007769 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 945713007770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 945713007771 active site 945713007772 KMSKS motif; other site 945713007773 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 945713007774 tRNA binding surface [nucleotide binding]; other site 945713007775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 945713007776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 945713007777 ligand binding site [chemical binding]; other site 945713007778 flexible hinge region; other site 945713007779 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 945713007780 Aspartase; Region: Aspartase; cd01357 945713007781 active sites [active] 945713007782 tetramer interface [polypeptide binding]; other site 945713007783 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007784 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 945713007785 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 945713007786 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007787 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007788 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007789 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 945713007790 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713007791 catalytic residues [active] 945713007792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007793 S-adenosylmethionine binding site [chemical binding]; other site 945713007794 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 945713007795 Protein of unknown function, DUF485; Region: DUF485; pfam04341 945713007796 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713007797 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713007798 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713007799 putative active site [active] 945713007800 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 945713007801 YceI-like domain; Region: YceI; pfam04264 945713007802 hydroxyglutarate oxidase; Provisional; Region: PRK11728 945713007803 Predicted dehydrogenase [General function prediction only]; Region: COG0579 945713007804 DNA methylase; Region: N6_N4_Mtase; pfam01555 945713007805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007806 S-adenosylmethionine binding site [chemical binding]; other site 945713007807 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 945713007808 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 945713007809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 945713007810 Beta-Casp domain; Region: Beta-Casp; smart01027 945713007811 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 945713007812 type I citrate synthase; Reviewed; Region: PRK09569 945713007813 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 945713007814 oxalacetate binding site [chemical binding]; other site 945713007815 citrylCoA binding site [chemical binding]; other site 945713007816 coenzyme A binding site [chemical binding]; other site 945713007817 catalytic triad [active] 945713007818 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 945713007819 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 945713007820 acyl-activating enzyme (AAE) consensus motif; other site 945713007821 putative AMP binding site [chemical binding]; other site 945713007822 putative active site [active] 945713007823 putative CoA binding site [chemical binding]; other site 945713007824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713007825 Coenzyme A binding pocket [chemical binding]; other site 945713007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713007827 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 945713007828 putative substrate translocation pore; other site 945713007829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 945713007830 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 945713007831 intracellular protease, PfpI family; Region: PfpI; TIGR01382 945713007832 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 945713007833 proposed catalytic triad [active] 945713007834 conserved cys residue [active] 945713007835 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 945713007836 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 945713007837 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713007838 active site 945713007839 catalytic site [active] 945713007840 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 945713007841 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 945713007842 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 945713007843 putative RNA binding site [nucleotide binding]; other site 945713007844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007845 S-adenosylmethionine binding site [chemical binding]; other site 945713007846 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 945713007847 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 945713007848 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 945713007849 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 945713007850 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 945713007851 active site 945713007852 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 945713007853 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713007854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713007855 S-adenosylmethionine binding site [chemical binding]; other site 945713007856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713007857 dimerization interface [polypeptide binding]; other site 945713007858 putative DNA binding site [nucleotide binding]; other site 945713007859 putative Zn2+ binding site [ion binding]; other site 945713007860 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 945713007861 active site 945713007862 dimer interface [polypeptide binding]; other site 945713007863 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 945713007864 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 945713007865 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 945713007866 active site 945713007867 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 945713007868 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 945713007869 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 945713007870 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 945713007871 active site 945713007872 dimer interface [polypeptide binding]; other site 945713007873 HEAT repeats; Region: HEAT_2; pfam13646 945713007874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713007875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713007876 active site 945713007877 phosphorylation site [posttranslational modification] 945713007878 intermolecular recognition site; other site 945713007879 dimerization interface [polypeptide binding]; other site 945713007880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 945713007881 DNA binding site [nucleotide binding] 945713007882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713007883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713007884 dimer interface [polypeptide binding]; other site 945713007885 phosphorylation site [posttranslational modification] 945713007886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713007887 ATP binding site [chemical binding]; other site 945713007888 Mg2+ binding site [ion binding]; other site 945713007889 G-X-G motif; other site 945713007890 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 945713007891 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 945713007892 acyl-activating enzyme (AAE) consensus motif; other site 945713007893 putative AMP binding site [chemical binding]; other site 945713007894 putative active site [active] 945713007895 putative CoA binding site [chemical binding]; other site 945713007896 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 945713007897 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 945713007898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 945713007899 putative acyl-acceptor binding pocket; other site 945713007900 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 945713007901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713007902 methionine gamma-lyase; Region: PLN02242 945713007903 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 945713007904 homodimer interface [polypeptide binding]; other site 945713007905 substrate-cofactor binding pocket; other site 945713007906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713007907 catalytic residue [active] 945713007908 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 945713007909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713007910 putative DNA binding site [nucleotide binding]; other site 945713007911 putative Zn2+ binding site [ion binding]; other site 945713007912 AsnC family; Region: AsnC_trans_reg; pfam01037 945713007913 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 945713007914 tetramer (dimer of dimers) interface [polypeptide binding]; other site 945713007915 active site 945713007916 dimer interface [polypeptide binding]; other site 945713007917 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007918 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713007919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713007920 TPR motif; other site 945713007921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713007922 PAS domain; Region: PAS_9; pfam13426 945713007923 putative active site [active] 945713007924 heme pocket [chemical binding]; other site 945713007925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713007926 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 945713007927 Walker A motif; other site 945713007928 ATP binding site [chemical binding]; other site 945713007929 Walker B motif; other site 945713007930 arginine finger; other site 945713007931 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713007932 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 945713007933 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713007934 GIY-YIG motif/motif A; other site 945713007935 putative active site [active] 945713007936 putative metal binding site [ion binding]; other site 945713007937 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 945713007938 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713007939 active site 945713007940 homodimer interface [polypeptide binding]; other site 945713007941 catalytic site [active] 945713007942 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 945713007943 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 945713007944 NADP binding site [chemical binding]; other site 945713007945 active site 945713007946 putative substrate binding site [chemical binding]; other site 945713007947 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 945713007948 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 945713007949 substrate binding site [chemical binding]; other site 945713007950 ATP binding site [chemical binding]; other site 945713007951 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 945713007952 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 945713007953 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 945713007954 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 945713007955 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 945713007956 Uncharacterized conserved protein [Function unknown]; Region: COG3270 945713007957 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 945713007958 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 945713007959 ArsC family; Region: ArsC; pfam03960 945713007960 catalytic residue [active] 945713007961 glutamine synthetase, type I; Region: GlnA; TIGR00653 945713007962 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 945713007963 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 945713007964 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 945713007965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713007966 putative DNA binding site [nucleotide binding]; other site 945713007967 putative Zn2+ binding site [ion binding]; other site 945713007968 AsnC family; Region: AsnC_trans_reg; pfam01037 945713007969 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713007970 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 945713007971 Substrate binding site; other site 945713007972 metal-binding site 945713007973 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 945713007974 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 945713007975 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713007976 FG-GAP repeat; Region: FG-GAP_2; pfam14312 945713007977 FG-GAP repeat; Region: FG-GAP_2; pfam14312 945713007978 FG-GAP repeat; Region: FG-GAP_2; pfam14312 945713007979 FG-GAP repeat; Region: FG-GAP_2; pfam14312 945713007980 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713007981 SurA N-terminal domain; Region: SurA_N_3; cl07813 945713007982 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 945713007983 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 945713007984 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 945713007985 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 945713007986 active site 945713007987 oxyanion hole [active] 945713007988 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 945713007989 catalytic triad [active] 945713007990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713007991 TPR motif; other site 945713007992 binding surface 945713007993 Tetratricopeptide repeat; Region: TPR_16; pfam13432 945713007994 pullulanase, type I; Region: pulA_typeI; TIGR02104 945713007995 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 945713007996 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 945713007997 active site 945713007998 catalytic site [active] 945713007999 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 945713008000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 945713008001 NAD(P) binding site [chemical binding]; other site 945713008002 tellurium resistance terB-like protein; Region: terB_like; cl11965 945713008003 metal binding site [ion binding]; metal-binding site 945713008004 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 945713008005 Zn binding site [ion binding]; other site 945713008006 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 945713008007 putative active site [active] 945713008008 Zn binding site [ion binding]; other site 945713008009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713008010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008011 ATP binding site [chemical binding]; other site 945713008012 Mg2+ binding site [ion binding]; other site 945713008013 G-X-G motif; other site 945713008014 fumarate hydratase; Reviewed; Region: fumC; PRK00485 945713008015 Class II fumarases; Region: Fumarase_classII; cd01362 945713008016 active site 945713008017 tetramer interface [polypeptide binding]; other site 945713008018 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 945713008019 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 945713008020 substrate-cofactor binding pocket; other site 945713008021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713008022 catalytic residue [active] 945713008023 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 945713008024 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 945713008025 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 945713008026 putative ADP-ribose binding site [chemical binding]; other site 945713008027 putative active site [active] 945713008028 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945713008029 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 945713008030 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 945713008031 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 945713008032 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 945713008033 catalytic site [active] 945713008034 subunit interface [polypeptide binding]; other site 945713008035 Uncharacterized conserved protein [Function unknown]; Region: COG2353 945713008036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713008037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008038 binding surface 945713008039 TPR motif; other site 945713008040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713008041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008042 binding surface 945713008043 TPR motif; other site 945713008044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713008045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713008046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713008047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713008048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713008049 dimer interface [polypeptide binding]; other site 945713008050 phosphorylation site [posttranslational modification] 945713008051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008052 ATP binding site [chemical binding]; other site 945713008053 Mg2+ binding site [ion binding]; other site 945713008054 G-X-G motif; other site 945713008055 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 945713008056 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 945713008057 putative active site [active] 945713008058 PhoH-like protein; Region: PhoH; pfam02562 945713008059 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 945713008060 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 945713008061 Ligand Binding Site [chemical binding]; other site 945713008062 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 945713008063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713008064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713008065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713008066 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 945713008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008068 active site 945713008069 phosphorylation site [posttranslational modification] 945713008070 intermolecular recognition site; other site 945713008071 dimerization interface [polypeptide binding]; other site 945713008072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713008073 PAS fold; Region: PAS_3; pfam08447 945713008074 putative active site [active] 945713008075 heme pocket [chemical binding]; other site 945713008076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713008077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713008078 dimer interface [polypeptide binding]; other site 945713008079 phosphorylation site [posttranslational modification] 945713008080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008081 ATP binding site [chemical binding]; other site 945713008082 Mg2+ binding site [ion binding]; other site 945713008083 G-X-G motif; other site 945713008084 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 945713008085 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 945713008086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713008087 catalytic residue [active] 945713008088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 945713008089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008090 active site 945713008091 phosphorylation site [posttranslational modification] 945713008092 intermolecular recognition site; other site 945713008093 dimerization interface [polypeptide binding]; other site 945713008094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 945713008095 DNA binding residues [nucleotide binding] 945713008096 dimerization interface [polypeptide binding]; other site 945713008097 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 945713008098 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 945713008099 Histidine kinase; Region: HisKA_3; pfam07730 945713008100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008101 ATP binding site [chemical binding]; other site 945713008102 Mg2+ binding site [ion binding]; other site 945713008103 G-X-G motif; other site 945713008104 Pirin-related protein [General function prediction only]; Region: COG1741 945713008105 Pirin; Region: Pirin; pfam02678 945713008106 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 945713008107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008108 S-adenosylmethionine binding site [chemical binding]; other site 945713008109 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713008110 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 945713008111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713008112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713008113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713008114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008115 S-adenosylmethionine binding site [chemical binding]; other site 945713008116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713008117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008118 S-adenosylmethionine binding site [chemical binding]; other site 945713008119 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713008120 B12 binding site [chemical binding]; other site 945713008121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713008122 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 945713008123 FeS/SAM binding site; other site 945713008124 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 945713008125 active site 945713008126 NTP binding site [chemical binding]; other site 945713008127 metal binding triad [ion binding]; metal-binding site 945713008128 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 945713008129 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 945713008130 dimer interface [polypeptide binding]; other site 945713008131 PYR/PP interface [polypeptide binding]; other site 945713008132 TPP binding site [chemical binding]; other site 945713008133 substrate binding site [chemical binding]; other site 945713008134 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 945713008135 TPP-binding site; other site 945713008136 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 945713008137 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 945713008138 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 945713008139 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 945713008140 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 945713008141 active site 945713008142 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 945713008143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 945713008144 ABC-ATPase subunit interface; other site 945713008145 dimer interface [polypeptide binding]; other site 945713008146 putative PBP binding regions; other site 945713008147 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 945713008148 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 945713008149 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 945713008150 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 945713008151 intersubunit interface [polypeptide binding]; other site 945713008152 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 945713008153 DNA topoisomerase I; Provisional; Region: PRK08780 945713008154 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 945713008155 active site 945713008156 interdomain interaction site; other site 945713008157 putative metal-binding site [ion binding]; other site 945713008158 nucleotide binding site [chemical binding]; other site 945713008159 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 945713008160 domain I; other site 945713008161 DNA binding groove [nucleotide binding] 945713008162 phosphate binding site [ion binding]; other site 945713008163 domain II; other site 945713008164 domain III; other site 945713008165 nucleotide binding site [chemical binding]; other site 945713008166 catalytic site [active] 945713008167 domain IV; other site 945713008168 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 945713008169 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 945713008170 Haemolytic domain; Region: Haemolytic; pfam01809 945713008171 Transglycosylase; Region: Transgly; cl17702 945713008172 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 945713008173 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 945713008174 Domain of unknown function DUF20; Region: UPF0118; pfam01594 945713008175 Protein of unknown function (DUF497); Region: DUF497; pfam04365 945713008176 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 945713008177 putative active site [active] 945713008178 Zn binding site [ion binding]; other site 945713008179 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 945713008180 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008181 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 945713008182 ArsC family; Region: ArsC; pfam03960 945713008183 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 945713008184 oligomerisation interface [polypeptide binding]; other site 945713008185 mobile loop; other site 945713008186 roof hairpin; other site 945713008187 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 945713008188 catalytic residues [active] 945713008189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713008190 catalytic residues [active] 945713008191 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 945713008192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 945713008193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713008194 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 945713008195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713008196 Transposase domain (DUF772); Region: DUF772; pfam05598 945713008197 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713008198 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713008199 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713008200 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008201 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945713008202 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 945713008203 glutamine synthetase, type I; Region: GlnA; TIGR00653 945713008204 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 945713008205 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 945713008206 enolase; Provisional; Region: eno; PRK00077 945713008207 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 945713008208 dimer interface [polypeptide binding]; other site 945713008209 metal binding site [ion binding]; metal-binding site 945713008210 substrate binding pocket [chemical binding]; other site 945713008211 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 945713008212 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 945713008213 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 945713008214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 945713008215 Ligand Binding Site [chemical binding]; other site 945713008216 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 945713008217 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 945713008218 GTP binding site; other site 945713008219 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 945713008220 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 945713008221 dimer interface [polypeptide binding]; other site 945713008222 putative functional site; other site 945713008223 putative MPT binding site; other site 945713008224 MOSC domain; Region: MOSC; pfam03473 945713008225 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 945713008226 trimer interface [polypeptide binding]; other site 945713008227 dimer interface [polypeptide binding]; other site 945713008228 putative active site [active] 945713008229 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 945713008230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713008231 FeS/SAM binding site; other site 945713008232 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 945713008233 Chromate transporter; Region: Chromate_transp; pfam02417 945713008234 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 945713008235 tetrathionate reductase subunit A; Provisional; Region: PRK14991 945713008236 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 945713008237 molybdopterin cofactor binding site; other site 945713008238 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 945713008239 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 945713008240 putative molybdopterin cofactor binding site; other site 945713008241 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 945713008242 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 945713008243 4Fe-4S binding domain; Region: Fer4; pfam00037 945713008244 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 945713008245 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 945713008246 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713008247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008248 active site 945713008249 phosphorylation site [posttranslational modification] 945713008250 intermolecular recognition site; other site 945713008251 dimerization interface [polypeptide binding]; other site 945713008252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713008253 Walker A motif; other site 945713008254 ATP binding site [chemical binding]; other site 945713008255 Walker B motif; other site 945713008256 arginine finger; other site 945713008257 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713008258 GxxExxY protein; Region: GxxExxY; TIGR04256 945713008259 HAMP domain; Region: HAMP; pfam00672 945713008260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713008261 dimer interface [polypeptide binding]; other site 945713008262 phosphorylation site [posttranslational modification] 945713008263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008264 ATP binding site [chemical binding]; other site 945713008265 Mg2+ binding site [ion binding]; other site 945713008266 G-X-G motif; other site 945713008267 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 945713008268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 945713008269 substrate binding pocket [chemical binding]; other site 945713008270 membrane-bound complex binding site; other site 945713008271 hinge residues; other site 945713008272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713008273 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713008274 catalytic residues [active] 945713008275 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 945713008276 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 945713008277 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 945713008278 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 945713008279 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 945713008280 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 945713008281 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 945713008282 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 945713008283 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 945713008284 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 945713008285 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 945713008286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713008287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713008288 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 945713008289 OsmC-like protein; Region: OsmC; pfam02566 945713008290 Ferredoxin [Energy production and conversion]; Region: COG1146 945713008291 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 945713008292 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 945713008293 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 945713008294 Transposase IS200 like; Region: Y1_Tnp; pfam01797 945713008295 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713008296 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 945713008297 lipoyl-biotinyl attachment site [posttranslational modification]; other site 945713008298 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713008299 Outer membrane efflux protein; Region: OEP; pfam02321 945713008300 Outer membrane efflux protein; Region: OEP; pfam02321 945713008301 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 945713008302 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 945713008303 arsenical-resistance protein; Region: acr3; TIGR00832 945713008304 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 945713008305 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 945713008306 Low molecular weight phosphatase family; Region: LMWPc; cd00115 945713008307 active site 945713008308 GxxExxY protein; Region: GxxExxY; TIGR04256 945713008309 Predicted permease; Region: DUF318; cl17795 945713008310 Predicted permease; Region: DUF318; cl17795 945713008311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713008312 dimerization interface [polypeptide binding]; other site 945713008313 putative DNA binding site [nucleotide binding]; other site 945713008314 putative Zn2+ binding site [ion binding]; other site 945713008315 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 945713008316 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 945713008317 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 945713008318 putative active site [active] 945713008319 catalytic site [active] 945713008320 putative metal binding site [ion binding]; other site 945713008321 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 945713008322 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 945713008323 nucleophile elbow; other site 945713008324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713008325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713008326 Outer membrane efflux protein; Region: OEP; pfam02321 945713008327 Outer membrane efflux protein; Region: OEP; pfam02321 945713008328 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 945713008329 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 945713008330 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713008331 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 945713008332 Nitrogen regulatory protein P-II; Region: P-II; cl00412 945713008333 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 945713008334 catalytic residues [active] 945713008335 dimer interface [polypeptide binding]; other site 945713008336 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 945713008337 putative metal binding site [ion binding]; other site 945713008338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 945713008339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713008340 putative metal binding site [ion binding]; other site 945713008341 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 945713008342 homodimer interface [polypeptide binding]; other site 945713008343 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 945713008344 active site pocket [active] 945713008345 Alkaline phosphatase homologues; Region: alkPPc; smart00098 945713008346 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 945713008347 active site 945713008348 dimer interface [polypeptide binding]; other site 945713008349 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008350 peroxiredoxin; Provisional; Region: PRK13189 945713008351 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 945713008352 dimer interface [polypeptide binding]; other site 945713008353 decamer (pentamer of dimers) interface [polypeptide binding]; other site 945713008354 catalytic triad [active] 945713008355 EVE domain; Region: EVE; cl00728 945713008356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713008357 Coenzyme A binding pocket [chemical binding]; other site 945713008358 RmuC family; Region: RmuC; pfam02646 945713008359 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 945713008360 active sites [active] 945713008361 tetramer interface [polypeptide binding]; other site 945713008362 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 945713008363 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 945713008364 HflX GTPase family; Region: HflX; cd01878 945713008365 G1 box; other site 945713008366 GTP/Mg2+ binding site [chemical binding]; other site 945713008367 Switch I region; other site 945713008368 G2 box; other site 945713008369 G3 box; other site 945713008370 Switch II region; other site 945713008371 G4 box; other site 945713008372 G5 box; other site 945713008373 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 945713008374 von Willebrand factor type A domain; Region: VWA_2; pfam13519 945713008375 MarR family; Region: MarR_2; cl17246 945713008376 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 945713008377 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 945713008378 substrate binding site [chemical binding]; other site 945713008379 ligand binding site [chemical binding]; other site 945713008380 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 945713008381 substrate binding site [chemical binding]; other site 945713008382 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 945713008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008384 active site 945713008385 phosphorylation site [posttranslational modification] 945713008386 intermolecular recognition site; other site 945713008387 dimerization interface [polypeptide binding]; other site 945713008388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713008389 Walker A motif; other site 945713008390 ATP binding site [chemical binding]; other site 945713008391 Walker B motif; other site 945713008392 arginine finger; other site 945713008393 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 945713008394 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 945713008395 oligomerisation interface [polypeptide binding]; other site 945713008396 mobile loop; other site 945713008397 roof hairpin; other site 945713008398 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 945713008399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713008400 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 945713008401 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 945713008402 inhibitor-cofactor binding pocket; inhibition site 945713008403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713008404 catalytic residue [active] 945713008405 WxcM-like, C-terminal; Region: FdtA; pfam05523 945713008406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945713008407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008408 S-adenosylmethionine binding site [chemical binding]; other site 945713008409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945713008410 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 945713008411 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 945713008412 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 945713008413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713008414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008415 S-adenosylmethionine binding site [chemical binding]; other site 945713008416 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713008417 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 945713008418 Ligand binding site; other site 945713008419 Putative Catalytic site; other site 945713008420 DXD motif; other site 945713008421 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 945713008422 putative ABC transporter; Region: ycf24; CHL00085 945713008423 FeS assembly ATPase SufC; Region: sufC; TIGR01978 945713008424 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 945713008425 Walker A/P-loop; other site 945713008426 ATP binding site [chemical binding]; other site 945713008427 Q-loop/lid; other site 945713008428 ABC transporter signature motif; other site 945713008429 Walker B; other site 945713008430 D-loop; other site 945713008431 H-loop/switch region; other site 945713008432 FeS assembly protein SufD; Region: sufD; TIGR01981 945713008433 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 945713008434 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 945713008435 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 945713008436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 945713008437 catalytic residue [active] 945713008438 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 945713008439 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 945713008440 trimerization site [polypeptide binding]; other site 945713008441 active site 945713008442 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 945713008443 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 945713008444 Predicted transcriptional regulator [Transcription]; Region: COG1959 945713008445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 945713008446 putative DNA binding site [nucleotide binding]; other site 945713008447 putative Zn2+ binding site [ion binding]; other site 945713008448 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 945713008449 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 945713008450 active site 945713008451 octamer interface [polypeptide binding]; other site 945713008452 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 945713008453 active site 945713008454 Zn binding site [ion binding]; other site 945713008455 Transposase IS200 like; Region: Y1_Tnp; pfam01797 945713008456 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 945713008457 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 945713008458 proposed catalytic triad [active] 945713008459 active site nucleophile [active] 945713008460 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008461 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 945713008462 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713008463 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 945713008464 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 945713008465 N-terminal plug; other site 945713008466 ligand-binding site [chemical binding]; other site 945713008467 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 945713008468 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 945713008469 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 945713008470 putative active site [active] 945713008471 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008472 Predicted membrane protein [Function unknown]; Region: COG1288 945713008473 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 945713008474 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 945713008475 proposed catalytic triad [active] 945713008476 active site nucleophile [active] 945713008477 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713008478 peptidase T-like protein; Region: PepT-like; TIGR01883 945713008479 metal binding site [ion binding]; metal-binding site 945713008480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 945713008481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 945713008482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 945713008483 HlyD family secretion protein; Region: HlyD_3; pfam13437 945713008484 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 945713008485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713008486 Walker A/P-loop; other site 945713008487 ATP binding site [chemical binding]; other site 945713008488 Q-loop/lid; other site 945713008489 ABC transporter signature motif; other site 945713008490 Walker B; other site 945713008491 D-loop; other site 945713008492 H-loop/switch region; other site 945713008493 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 945713008494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 945713008495 Walker A/P-loop; other site 945713008496 ATP binding site [chemical binding]; other site 945713008497 Q-loop/lid; other site 945713008498 ABC transporter signature motif; other site 945713008499 Walker B; other site 945713008500 D-loop; other site 945713008501 H-loop/switch region; other site 945713008502 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 945713008503 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 945713008504 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 945713008505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 945713008506 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 945713008507 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 945713008508 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 945713008509 cyclase homology domain; Region: CHD; cd07302 945713008510 nucleotidyl binding site; other site 945713008511 metal binding site [ion binding]; metal-binding site 945713008512 dimer interface [polypeptide binding]; other site 945713008513 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 945713008514 active site 945713008515 Methyltransferase domain; Region: Methyltransf_31; pfam13847 945713008516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008517 S-adenosylmethionine binding site [chemical binding]; other site 945713008518 Predicted permeases [General function prediction only]; Region: COG0679 945713008519 Domain of unknown function DUF77; Region: DUF77; pfam01910 945713008520 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 945713008521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945713008522 catalytic core [active] 945713008523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945713008524 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 945713008526 Response regulator receiver domain; Region: Response_reg; pfam00072 945713008527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008528 active site 945713008529 phosphorylation site [posttranslational modification] 945713008530 intermolecular recognition site; other site 945713008531 dimerization interface [polypeptide binding]; other site 945713008532 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 945713008533 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 945713008534 catalytic residues [active] 945713008535 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 945713008536 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 945713008537 active site 945713008538 catalytic site [active] 945713008539 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 945713008540 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 945713008541 active site 945713008542 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 945713008543 GIY-YIG motif/motif A; other site 945713008544 putative active site [active] 945713008545 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008546 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 945713008547 putative active site [active] 945713008548 putative catalytic triad [active] 945713008549 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 945713008550 Fn3 associated; Region: Fn3_assoc; pfam13287 945713008551 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 945713008552 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 945713008553 dimer interface [polypeptide binding]; other site 945713008554 PYR/PP interface [polypeptide binding]; other site 945713008555 TPP binding site [chemical binding]; other site 945713008556 substrate binding site [chemical binding]; other site 945713008557 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 945713008558 Domain of unknown function; Region: EKR; pfam10371 945713008559 4Fe-4S binding domain; Region: Fer4_6; pfam12837 945713008560 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 945713008561 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 945713008562 TPP-binding site [chemical binding]; other site 945713008563 dimer interface [polypeptide binding]; other site 945713008564 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 945713008565 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 945713008566 putative active site [active] 945713008567 putative FMN binding site [chemical binding]; other site 945713008568 putative substrate binding site [chemical binding]; other site 945713008569 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 945713008570 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 945713008571 putative active site [active] 945713008572 putative metal binding site [ion binding]; other site 945713008573 ornithine carbamoyltransferase; Provisional; Region: PRK00779 945713008574 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 945713008575 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 945713008576 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 945713008577 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 945713008578 putative substrate binding site [chemical binding]; other site 945713008579 nucleotide binding site [chemical binding]; other site 945713008580 nucleotide binding site [chemical binding]; other site 945713008581 homodimer interface [polypeptide binding]; other site 945713008582 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 945713008583 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 945713008584 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 945713008585 active site 945713008586 glutamate dehydrogenase; Provisional; Region: PRK09414 945713008587 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 945713008588 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 945713008589 NAD(P) binding site [chemical binding]; other site 945713008590 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945713008591 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 945713008592 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 945713008593 active site 945713008594 Zn binding site [ion binding]; other site 945713008595 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008596 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 945713008597 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 945713008598 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 945713008599 ligand binding site [chemical binding]; other site 945713008600 NAD binding site [chemical binding]; other site 945713008601 catalytic site [active] 945713008602 homodimer interface [polypeptide binding]; other site 945713008603 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 945713008604 MgtE intracellular N domain; Region: MgtE_N; smart00924 945713008605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 945713008606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 945713008607 Divalent cation transporter; Region: MgtE; pfam01769 945713008608 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 945713008609 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 945713008610 substrate binding site; other site 945713008611 tetramer interface; other site 945713008612 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 945713008613 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 945713008614 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 945713008615 inhibitor-cofactor binding pocket; inhibition site 945713008616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713008617 catalytic residue [active] 945713008618 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 945713008619 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 945713008620 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 945713008621 NADP binding site [chemical binding]; other site 945713008622 active site 945713008623 putative substrate binding site [chemical binding]; other site 945713008624 TRAM domain; Region: TRAM; cl01282 945713008625 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 945713008626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008627 S-adenosylmethionine binding site [chemical binding]; other site 945713008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945713008629 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 945713008630 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713008631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713008632 Uncharacterized conserved protein [Function unknown]; Region: COG3339 945713008633 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 945713008634 dimer interface [polypeptide binding]; other site 945713008635 ADP-ribose binding site [chemical binding]; other site 945713008636 active site 945713008637 nudix motif; other site 945713008638 metal binding site [ion binding]; metal-binding site 945713008639 PcrB family; Region: PcrB; pfam01884 945713008640 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 945713008641 substrate binding site [chemical binding]; other site 945713008642 putative active site [active] 945713008643 dimer interface [polypeptide binding]; other site 945713008644 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 945713008645 dimer interface [polypeptide binding]; other site 945713008646 active site 945713008647 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 945713008648 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 945713008649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 945713008650 active site 945713008651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 945713008652 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 945713008653 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713008654 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 945713008655 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 945713008656 dimer interface [polypeptide binding]; other site 945713008657 TPP-binding site [chemical binding]; other site 945713008658 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 945713008659 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 945713008660 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945713008661 E3 interaction surface; other site 945713008662 lipoyl attachment site [posttranslational modification]; other site 945713008663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 945713008664 E3 interaction surface; other site 945713008665 lipoyl attachment site [posttranslational modification]; other site 945713008666 e3 binding domain; Region: E3_binding; pfam02817 945713008667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 945713008668 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 945713008669 four helix bundle protein; Region: TIGR02436 945713008670 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 945713008671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 945713008672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713008673 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 945713008674 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 945713008675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713008676 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 945713008677 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 945713008678 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 945713008679 catalytic residues [active] 945713008680 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 945713008681 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 945713008682 Cytochrome c; Region: Cytochrom_C; pfam00034 945713008683 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945713008684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 945713008685 S-adenosylmethionine binding site [chemical binding]; other site 945713008686 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008687 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 945713008688 tandem repeat interface [polypeptide binding]; other site 945713008689 oligomer interface [polypeptide binding]; other site 945713008690 active site residues [active] 945713008691 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 945713008692 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 945713008693 tandem repeat interface [polypeptide binding]; other site 945713008694 oligomer interface [polypeptide binding]; other site 945713008695 active site residues [active] 945713008696 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 945713008697 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 945713008698 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 945713008699 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 945713008700 Walker A/P-loop; other site 945713008701 ATP binding site [chemical binding]; other site 945713008702 Q-loop/lid; other site 945713008703 ABC transporter signature motif; other site 945713008704 Walker B; other site 945713008705 D-loop; other site 945713008706 H-loop/switch region; other site 945713008707 FOG: CBS domain [General function prediction only]; Region: COG0517 945713008708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 945713008709 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 945713008710 Lamin Tail Domain; Region: LTD; pfam00932 945713008711 CARDB; Region: CARDB; pfam07705 945713008712 Lamin Tail Domain; Region: LTD; pfam00932 945713008713 Lamin Tail Domain; Region: LTD; pfam00932 945713008714 Lamin Tail Domain; Region: LTD; pfam00932 945713008715 CARDB; Region: CARDB; pfam07705 945713008716 Lamin Tail Domain; Region: LTD; pfam00932 945713008717 Lamin Tail Domain; Region: LTD; pfam00932 945713008718 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713008719 short chain dehydrogenase; Provisional; Region: PRK07024 945713008720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 945713008721 NAD(P) binding site [chemical binding]; other site 945713008722 active site 945713008723 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 945713008724 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 945713008725 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 945713008726 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 945713008727 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 945713008728 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 945713008729 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 945713008730 active site 945713008731 HslU subunit interaction site [polypeptide binding]; other site 945713008732 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 945713008733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 945713008734 Walker A motif; other site 945713008735 ATP binding site [chemical binding]; other site 945713008736 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 945713008737 Walker B motif; other site 945713008738 arginine finger; other site 945713008739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 945713008740 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008741 ferrochelatase; Reviewed; Region: hemH; PRK00035 945713008742 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 945713008743 C-terminal domain interface [polypeptide binding]; other site 945713008744 active site 945713008745 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 945713008746 active site 945713008747 N-terminal domain interface [polypeptide binding]; other site 945713008748 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 945713008749 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 945713008750 oligomer interface [polypeptide binding]; other site 945713008751 metal binding site [ion binding]; metal-binding site 945713008752 metal binding site [ion binding]; metal-binding site 945713008753 Cl binding site [ion binding]; other site 945713008754 aspartate ring; other site 945713008755 basic sphincter; other site 945713008756 putative hydrophobic gate; other site 945713008757 periplasmic entrance; other site 945713008758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 945713008759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 945713008760 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 945713008761 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008762 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008763 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 945713008764 catalytic motif [active] 945713008765 Zn binding site [ion binding]; other site 945713008766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 945713008767 EamA-like transporter family; Region: EamA; pfam00892 945713008768 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713008769 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713008770 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 945713008771 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 945713008772 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 945713008773 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 945713008774 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008775 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008776 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 945713008777 Protein of unknown function (DUF493); Region: DUF493; pfam04359 945713008778 Predicted membrane protein [Function unknown]; Region: COG3650 945713008779 META domain; Region: META; pfam03724 945713008780 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713008781 catalytic residues [active] 945713008782 Domain of unknown function DUF302; Region: DUF302; cl01364 945713008783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 945713008784 active site residue [active] 945713008785 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 945713008786 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 945713008787 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 945713008788 BNR repeat-like domain; Region: BNR_2; pfam13088 945713008789 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 945713008790 Asp-box motif; other site 945713008791 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008792 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 945713008793 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 945713008794 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 945713008795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713008796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713008797 putative substrate translocation pore; other site 945713008798 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 945713008799 Cna protein B-type domain; Region: Cna_B_2; pfam13715 945713008800 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 945713008801 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 945713008802 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 945713008803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 945713008804 Predicted acetyltransferase [General function prediction only]; Region: COG2388 945713008805 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 945713008806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 945713008807 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 945713008808 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 945713008809 NAD(P) binding site [chemical binding]; other site 945713008810 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 945713008811 classical (c) SDRs; Region: SDR_c; cd05233 945713008812 NAD(P) binding site [chemical binding]; other site 945713008813 active site 945713008814 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 945713008815 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 945713008816 nudix motif; other site 945713008817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008818 binding surface 945713008819 TPR repeat; Region: TPR_11; pfam13414 945713008820 TPR motif; other site 945713008821 TPR repeat; Region: TPR_11; pfam13414 945713008822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008823 TPR motif; other site 945713008824 binding surface 945713008825 TPR repeat; Region: TPR_11; pfam13414 945713008826 TPR repeat; Region: TPR_11; pfam13414 945713008827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008828 binding surface 945713008829 TPR motif; other site 945713008830 4Fe-4S binding domain; Region: Fer4; cl02805 945713008831 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 945713008832 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 945713008833 Bacterial sugar transferase; Region: Bac_transf; pfam02397 945713008834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713008835 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 945713008836 putative ADP-binding pocket [chemical binding]; other site 945713008837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 945713008838 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 945713008839 putative ADP-binding pocket [chemical binding]; other site 945713008840 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 945713008841 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 945713008842 metal-binding site 945713008843 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 945713008844 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 945713008845 Methyltransferase domain; Region: Methyltransf_23; pfam13489 945713008846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 945713008847 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 945713008848 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 945713008849 putative active site [active] 945713008850 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 945713008851 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 945713008852 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713008853 catalytic residues [active] 945713008854 heat shock protein HtpX; Provisional; Region: PRK03982 945713008855 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 945713008856 SlyX; Region: SlyX; cl01090 945713008857 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 945713008858 Family description; Region: VCBS; pfam13517 945713008859 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008860 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713008861 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 945713008862 Walker A/P-loop; other site 945713008863 ATP binding site [chemical binding]; other site 945713008864 Q-loop/lid; other site 945713008865 ABC transporter signature motif; other site 945713008866 Walker B; other site 945713008867 D-loop; other site 945713008868 H-loop/switch region; other site 945713008869 CcmB protein; Region: CcmB; cl17444 945713008870 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 945713008871 CcmE; Region: CcmE; cl00994 945713008872 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 945713008873 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 945713008874 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 945713008875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713008876 FeS/SAM binding site; other site 945713008877 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 945713008878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 945713008879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 945713008880 Coenzyme A binding pocket [chemical binding]; other site 945713008881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713008882 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 945713008883 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 945713008884 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713008885 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 945713008886 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 945713008887 generic binding surface II; other site 945713008888 ssDNA binding site; other site 945713008889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 945713008890 ATP binding site [chemical binding]; other site 945713008891 putative Mg++ binding site [ion binding]; other site 945713008892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 945713008893 nucleotide binding region [chemical binding]; other site 945713008894 ATP-binding site [chemical binding]; other site 945713008895 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 945713008896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 945713008897 Zn2+ binding site [ion binding]; other site 945713008898 Mg2+ binding site [ion binding]; other site 945713008899 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 945713008900 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 945713008901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 945713008902 putative active site [active] 945713008903 heme pocket [chemical binding]; other site 945713008904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 945713008905 GAF domain; Region: GAF_3; pfam13492 945713008906 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 945713008907 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 945713008908 PAS domain; Region: PAS_9; pfam13426 945713008909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713008910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713008911 dimer interface [polypeptide binding]; other site 945713008912 phosphorylation site [posttranslational modification] 945713008913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713008914 ATP binding site [chemical binding]; other site 945713008915 Mg2+ binding site [ion binding]; other site 945713008916 G-X-G motif; other site 945713008917 Response regulator receiver domain; Region: Response_reg; pfam00072 945713008918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713008919 active site 945713008920 phosphorylation site [posttranslational modification] 945713008921 intermolecular recognition site; other site 945713008922 dimerization interface [polypeptide binding]; other site 945713008923 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 945713008924 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 945713008925 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 945713008926 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 945713008927 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 945713008928 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 945713008929 DNA binding site [nucleotide binding] 945713008930 active site 945713008931 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 945713008932 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 945713008933 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 945713008934 active site 945713008935 homotetramer interface [polypeptide binding]; other site 945713008936 homodimer interface [polypeptide binding]; other site 945713008937 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 945713008938 triosephosphate isomerase; Provisional; Region: PRK14565 945713008939 substrate binding site [chemical binding]; other site 945713008940 dimer interface [polypeptide binding]; other site 945713008941 catalytic triad [active] 945713008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 945713008943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 945713008944 putative substrate translocation pore; other site 945713008945 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 945713008946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713008947 FeS/SAM binding site; other site 945713008948 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 945713008949 EamA-like transporter family; Region: EamA; pfam00892 945713008950 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 945713008951 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008952 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 945713008953 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 945713008954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 945713008955 FeS/SAM binding site; other site 945713008956 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 945713008957 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713008958 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713008959 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 945713008960 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 945713008961 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 945713008962 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 945713008963 protein binding site [polypeptide binding]; other site 945713008964 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 945713008965 Domain interface; other site 945713008966 Peptide binding site; other site 945713008967 Active site tetrad [active] 945713008968 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 945713008969 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 945713008970 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 945713008971 active site 945713008972 metal binding site [ion binding]; metal-binding site 945713008973 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 945713008974 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 945713008975 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 945713008976 inhibitor-cofactor binding pocket; inhibition site 945713008977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713008978 catalytic residue [active] 945713008979 Domain of unknown function (DU1801); Region: DUF1801; cl17490 945713008980 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945713008981 active site 945713008982 catalytic residues [active] 945713008983 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008984 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008985 Flagellin N-methylase; Region: FliB; cl00497 945713008986 transketolase; Reviewed; Region: PRK05899 945713008987 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 945713008988 TPP-binding site [chemical binding]; other site 945713008989 dimer interface [polypeptide binding]; other site 945713008990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 945713008991 PYR/PP interface [polypeptide binding]; other site 945713008992 dimer interface [polypeptide binding]; other site 945713008993 TPP binding site [chemical binding]; other site 945713008994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 945713008995 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 945713008996 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008997 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713008998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713008999 binding surface 945713009000 TPR motif; other site 945713009001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009003 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009004 Yip1 domain; Region: Yip1; pfam04893 945713009005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 945713009006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 945713009007 Walker A/P-loop; other site 945713009008 ATP binding site [chemical binding]; other site 945713009009 Q-loop/lid; other site 945713009010 ABC transporter signature motif; other site 945713009011 Walker B; other site 945713009012 D-loop; other site 945713009013 H-loop/switch region; other site 945713009014 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 945713009015 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713009016 FtsX-like permease family; Region: FtsX; pfam02687 945713009017 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 945713009018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 945713009019 FtsX-like permease family; Region: FtsX; pfam02687 945713009020 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 945713009021 Trm112p-like protein; Region: Trm112p; cl01066 945713009022 intracellular protease, PfpI family; Region: PfpI; TIGR01382 945713009023 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 945713009024 conserved cys residue [active] 945713009025 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 945713009026 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 945713009027 acyl-activating enzyme (AAE) consensus motif; other site 945713009028 putative AMP binding site [chemical binding]; other site 945713009029 putative active site [active] 945713009030 putative CoA binding site [chemical binding]; other site 945713009031 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 945713009032 methionine sulfoxide reductase B; Provisional; Region: PRK00222 945713009033 SelR domain; Region: SelR; pfam01641 945713009034 Low molecular weight phosphatase family; Region: LMWPc; cl00105 945713009035 active site 945713009036 H-type lectin domain; Region: H_lectin; pfam09458 945713009037 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 945713009038 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 945713009039 homodimer interface [polypeptide binding]; other site 945713009040 substrate-cofactor binding pocket; other site 945713009041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 945713009042 catalytic residue [active] 945713009043 DNA polymerase II; Reviewed; Region: PRK05762 945713009044 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 945713009045 active site 945713009046 catalytic site [active] 945713009047 substrate binding site [chemical binding]; other site 945713009048 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 945713009049 active site 945713009050 metal-binding site 945713009051 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 945713009052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 945713009053 Beta-Casp domain; Region: Beta-Casp; smart01027 945713009054 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 945713009055 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 945713009056 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 945713009057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 945713009058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 945713009059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713009060 DNA binding residues [nucleotide binding] 945713009061 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 945713009062 putative ligand binding site [chemical binding]; other site 945713009063 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 945713009064 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 945713009065 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 945713009066 NADP-binding site; other site 945713009067 homotetramer interface [polypeptide binding]; other site 945713009068 substrate binding site [chemical binding]; other site 945713009069 homodimer interface [polypeptide binding]; other site 945713009070 active site 945713009071 peptidase T; Region: peptidase-T; TIGR01882 945713009072 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 945713009073 metal binding site [ion binding]; metal-binding site 945713009074 dimer interface [polypeptide binding]; other site 945713009075 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 945713009076 Peptidase family U32; Region: Peptidase_U32; pfam01136 945713009077 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 945713009078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713009079 Interdomain contacts; other site 945713009080 Cytokine receptor motif; other site 945713009081 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 945713009082 Interdomain contacts; other site 945713009083 Cytokine receptor motif; other site 945713009084 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 945713009085 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 945713009086 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 945713009087 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 945713009088 prolyl-tRNA synthetase; Provisional; Region: PRK09194 945713009089 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945713009090 motif 1; other site 945713009091 dimer interface [polypeptide binding]; other site 945713009092 active site 945713009093 motif 2; other site 945713009094 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 945713009095 putative deacylase active site [active] 945713009096 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 945713009097 active site 945713009098 motif 3; other site 945713009099 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 945713009100 anticodon binding site; other site 945713009101 OPT oligopeptide transporter protein; Region: OPT; pfam03169 945713009102 putative oligopeptide transporter, OPT family; Region: TIGR00733 945713009103 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 945713009104 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 945713009105 active site 945713009106 catalytic residues [active] 945713009107 Predicted methyltransferases [General function prediction only]; Region: COG0313 945713009108 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 945713009109 putative SAM binding site [chemical binding]; other site 945713009110 putative homodimer interface [polypeptide binding]; other site 945713009111 Nudix hydrolase homolog; Region: PLN02791 945713009112 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 945713009113 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 945713009114 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 945713009115 putative FMN binding site [chemical binding]; other site 945713009116 Transposase domain (DUF772); Region: DUF772; pfam05598 945713009117 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 945713009118 DDE superfamily endonuclease; Region: DDE_4; cl17710 945713009119 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 945713009120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 945713009121 Histidine kinase; Region: HisKA_2; pfam07568 945713009122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713009123 ATP binding site [chemical binding]; other site 945713009124 Mg2+ binding site [ion binding]; other site 945713009125 G-X-G motif; other site 945713009126 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 945713009127 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 945713009128 N-acetyl-D-glucosamine binding site [chemical binding]; other site 945713009129 catalytic residue [active] 945713009130 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 945713009131 catalytic residues [active] 945713009132 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 945713009133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 945713009134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713009136 binding surface 945713009137 TPR motif; other site 945713009138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713009140 binding surface 945713009141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 945713009142 TPR motif; other site 945713009143 CHAT domain; Region: CHAT; pfam12770 945713009144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 945713009145 binding surface 945713009146 TPR repeat; Region: TPR_11; pfam13414 945713009147 TPR motif; other site 945713009148 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 945713009149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 945713009150 DNA binding residues [nucleotide binding] 945713009151 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713009152 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 945713009153 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713009154 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 945713009155 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 945713009156 Two component regulator propeller; Region: Reg_prop; pfam07494 945713009157 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 945713009158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 945713009159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 945713009160 dimer interface [polypeptide binding]; other site 945713009161 phosphorylation site [posttranslational modification] 945713009162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 945713009163 ATP binding site [chemical binding]; other site 945713009164 Mg2+ binding site [ion binding]; other site 945713009165 G-X-G motif; other site 945713009166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 945713009167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 945713009168 active site 945713009169 phosphorylation site [posttranslational modification] 945713009170 intermolecular recognition site; other site 945713009171 dimerization interface [polypeptide binding]; other site 945713009172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 945713009173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 945713009174 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 945713009175 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 945713009176 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 945713009177 active site 945713009178 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 945713009179 Transposase; Region: DEDD_Tnp_IS110; pfam01548 945713009180 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 945713009181 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 945713009182 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945713009183 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713009184 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 945713009185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 945713009186 ATP-grasp domain; Region: ATP-grasp_4; cl17255 945713009187 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 945713009188 substrate binding site [chemical binding]; other site 945713009189 Peptidase family M48; Region: Peptidase_M48; pfam01435 945713009190 GTP-binding protein YchF; Reviewed; Region: PRK09601 945713009191 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 945713009192 G1 box; other site 945713009193 GTP/Mg2+ binding site [chemical binding]; other site 945713009194 G2 box; other site 945713009195 Switch I region; other site 945713009196 G3 box; other site 945713009197 Switch II region; other site 945713009198 G4 box; other site 945713009199 G5 box; other site 945713009200 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 945713009201 AAA domain; Region: AAA_14; pfam13173 945713009202 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 945713009203 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 945713009204 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 945713009205 PA/protease or protease-like domain interface [polypeptide binding]; other site 945713009206 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 945713009207 Peptidase family M28; Region: Peptidase_M28; pfam04389 945713009208 metal binding site [ion binding]; metal-binding site 945713009209 Transcriptional regulators [Transcription]; Region: MarR; COG1846 945713009210 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 945713009211 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 945713009212 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 945713009213 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 945713009214 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 945713009215 substrate binding pocket [chemical binding]; other site 945713009216 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713009217 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 945713009218 putative active site [active] 945713009219 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 945713009220 B12 binding site [chemical binding]; other site 945713009221 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 945713009222 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 945713009223 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 945713009224 NADP binding site [chemical binding]; other site 945713009225 homopentamer interface [polypeptide binding]; other site 945713009226 substrate binding site [chemical binding]; other site 945713009227 active site 945713009228 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 945713009229 putative active site [active] 945713009230 nucleotide binding site [chemical binding]; other site 945713009231 nudix motif; other site 945713009232 putative metal binding site [ion binding]; other site 945713009233 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 945713009234 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 945713009235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 945713009236 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 945713009237 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 945713009238 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 945713009239 Family description; Region: UvrD_C_2; pfam13538 945713009240 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 945713009241 Predicted transcriptional regulators [Transcription]; Region: COG1733 945713009242 Predicted transcriptional regulators [Transcription]; Region: COG1733 945713009243 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 945713009244 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 945713009245 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 945713009246 active site 945713009247 nucleophile elbow; other site 945713009248 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713009249 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 945713009250 Surface antigen; Region: Bac_surface_Ag; pfam01103 945713009251 membrane protein insertase; Provisional; Region: PRK01318 945713009252 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 945713009253 ribonuclease P; Reviewed; Region: rnpA; PRK01903 945713009254 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399