-- dump date   	20140619_120111
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
743718000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
743718000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718000003	Walker A motif; other site
743718000004	ATP binding site [chemical binding]; other site
743718000005	Walker B motif; other site
743718000006	arginine finger; other site
743718000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
743718000008	DnaA box-binding interface [nucleotide binding]; other site
743718000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
743718000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
743718000011	putative DNA binding surface [nucleotide binding]; other site
743718000012	dimer interface [polypeptide binding]; other site
743718000013	beta-clamp/clamp loader binding surface; other site
743718000014	beta-clamp/translesion DNA polymerase binding surface; other site
743718000015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
743718000016	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
743718000017	recombination protein F; Reviewed; Region: recF; PRK00064
743718000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
743718000019	Walker A/P-loop; other site
743718000020	ATP binding site [chemical binding]; other site
743718000021	Q-loop/lid; other site
743718000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718000023	ABC transporter signature motif; other site
743718000024	Walker B; other site
743718000025	D-loop; other site
743718000026	H-loop/switch region; other site
743718000027	Protein of unknown function (DUF721); Region: DUF721; cl02324
743718000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
743718000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718000030	Mg2+ binding site [ion binding]; other site
743718000031	G-X-G motif; other site
743718000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
743718000033	anchoring element; other site
743718000034	dimer interface [polypeptide binding]; other site
743718000035	ATP binding site [chemical binding]; other site
743718000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
743718000037	active site
743718000038	putative metal-binding site [ion binding]; other site
743718000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
743718000040	DNA gyrase subunit A; Validated; Region: PRK05560
743718000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
743718000042	CAP-like domain; other site
743718000043	active site
743718000044	primary dimer interface [polypeptide binding]; other site
743718000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743718000051	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
743718000052	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
743718000053	active site
743718000054	Rhomboid family; Region: Rhomboid; pfam01694
743718000055	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
743718000056	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
743718000057	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
743718000058	active site
743718000059	catalytic site [active]
743718000060	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
743718000061	Glutamine amidotransferase class-I; Region: GATase; pfam00117
743718000062	glutamine binding [chemical binding]; other site
743718000063	catalytic triad [active]
743718000064	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
743718000065	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743718000066	active site
743718000067	ATP binding site [chemical binding]; other site
743718000068	substrate binding site [chemical binding]; other site
743718000069	activation loop (A-loop); other site
743718000070	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718000071	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718000072	PASTA domain; Region: PASTA; pfam03793
743718000073	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718000074	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743718000075	Catalytic domain of Protein Kinases; Region: PKc; cd00180
743718000076	active site
743718000077	ATP binding site [chemical binding]; other site
743718000078	substrate binding site [chemical binding]; other site
743718000079	activation loop (A-loop); other site
743718000080	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
743718000081	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
743718000082	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
743718000083	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
743718000084	active site
743718000085	FHA domain; Region: FHA; pfam00498
743718000086	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
743718000087	phosphopeptide binding site; other site
743718000088	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
743718000089	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
743718000090	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
743718000091	phosphopeptide binding site; other site
743718000092	Amb_all domain; Region: Amb_all; smart00656
743718000093	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
743718000094	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718000095	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718000096	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
743718000097	NAD(P) binding site [chemical binding]; other site
743718000098	active site
743718000099	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743718000100	Low molecular weight phosphatase family; Region: LMWPc; cd00115
743718000101	active site
743718000102	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718000103	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
743718000104	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
743718000105	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
743718000106	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
743718000107	active site
743718000108	catalytic site [active]
743718000109	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
743718000110	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
743718000111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718000112	active site
743718000113	motif I; other site
743718000114	motif II; other site
743718000115	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
743718000116	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
743718000117	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
743718000118	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
743718000119	reactive center loop; other site
743718000120	aspartate aminotransferase; Provisional; Region: PRK05764
743718000121	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718000122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000123	homodimer interface [polypeptide binding]; other site
743718000124	catalytic residue [active]
743718000125	PAS fold; Region: PAS_3; pfam08447
743718000126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
743718000127	heme pocket [chemical binding]; other site
743718000128	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
743718000129	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
743718000130	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
743718000131	NAD binding site [chemical binding]; other site
743718000132	metal binding site [ion binding]; metal-binding site
743718000133	active site
743718000134	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743718000135	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743718000136	putative catalytic site [active]
743718000137	putative metal binding site [ion binding]; other site
743718000138	putative phosphate binding site [ion binding]; other site
743718000139	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743718000140	putative metal binding site [ion binding]; other site
743718000141	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
743718000142	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743718000143	NAD binding site [chemical binding]; other site
743718000144	catalytic Zn binding site [ion binding]; other site
743718000145	structural Zn binding site [ion binding]; other site
743718000146	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718000147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000148	dimer interface [polypeptide binding]; other site
743718000149	conserved gate region; other site
743718000150	putative PBP binding loops; other site
743718000151	ABC-ATPase subunit interface; other site
743718000152	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
743718000153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000154	dimer interface [polypeptide binding]; other site
743718000155	conserved gate region; other site
743718000156	putative PBP binding loops; other site
743718000157	ABC-ATPase subunit interface; other site
743718000158	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718000159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718000160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718000161	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718000162	dimerization interface [polypeptide binding]; other site
743718000163	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
743718000164	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
743718000165	substrate binding site [chemical binding]; other site
743718000166	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
743718000167	glycine dehydrogenase; Provisional; Region: PRK05367
743718000168	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
743718000169	tetramer interface [polypeptide binding]; other site
743718000170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000171	catalytic residue [active]
743718000172	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
743718000173	tetramer interface [polypeptide binding]; other site
743718000174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000175	catalytic residue [active]
743718000176	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
743718000177	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
743718000178	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
743718000179	lipoyl attachment site [posttranslational modification]; other site
743718000180	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718000181	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718000182	DNA binding residues [nucleotide binding]
743718000183	dimerization interface [polypeptide binding]; other site
743718000184	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
743718000185	active site
743718000186	8-oxo-dGMP binding site [chemical binding]; other site
743718000187	nudix motif; other site
743718000188	metal binding site [ion binding]; metal-binding site
743718000189	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
743718000190	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718000191	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
743718000192	metal binding site [ion binding]; metal-binding site
743718000193	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
743718000194	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
743718000195	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
743718000196	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
743718000197	putative dimer interface [polypeptide binding]; other site
743718000198	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
743718000199	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
743718000200	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
743718000201	substrate binding site [chemical binding]; other site
743718000202	THF binding site; other site
743718000203	zinc-binding site [ion binding]; other site
743718000204	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
743718000205	FAD binding site [chemical binding]; other site
743718000206	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
743718000207	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743718000208	putative NAD(P) binding site [chemical binding]; other site
743718000209	Uncharacterized conserved protein [Function unknown]; Region: COG1432
743718000210	LabA_like proteins; Region: LabA_like; cd06167
743718000211	putative metal binding site [ion binding]; other site
743718000212	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
743718000213	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
743718000214	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743718000215	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
743718000216	putative acyl-acceptor binding pocket; other site
743718000217	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
743718000218	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718000219	DNA binding residues [nucleotide binding]
743718000220	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
743718000221	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718000222	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718000223	active site
743718000224	Uncharacterized conserved protein [Function unknown]; Region: COG4850
743718000225	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
743718000226	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
743718000227	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718000228	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718000229	DNA binding site [nucleotide binding]
743718000230	domain linker motif; other site
743718000231	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718000232	dimerization interface [polypeptide binding]; other site
743718000233	ligand binding site [chemical binding]; other site
743718000234	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743718000235	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
743718000236	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718000237	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718000238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000239	dimer interface [polypeptide binding]; other site
743718000240	conserved gate region; other site
743718000241	putative PBP binding loops; other site
743718000242	ABC-ATPase subunit interface; other site
743718000243	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718000244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000245	dimer interface [polypeptide binding]; other site
743718000246	conserved gate region; other site
743718000247	putative PBP binding loops; other site
743718000248	ABC-ATPase subunit interface; other site
743718000249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743718000250	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743718000251	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
743718000252	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
743718000253	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
743718000254	putative active site [active]
743718000255	putative catalytic site [active]
743718000256	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743718000257	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
743718000258	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
743718000259	putative metal binding site [ion binding]; other site
743718000260	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
743718000261	Ca binding site [ion binding]; other site
743718000262	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
743718000263	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
743718000264	dimer interface [polypeptide binding]; other site
743718000265	active site
743718000266	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
743718000267	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718000268	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718000269	DNA binding residues [nucleotide binding]
743718000270	dimerization interface [polypeptide binding]; other site
743718000271	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
743718000272	putative ADP-ribose binding site [chemical binding]; other site
743718000273	putative active site [active]
743718000274	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
743718000275	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
743718000276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718000277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743718000278	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743718000279	TadE-like protein; Region: TadE; pfam07811
743718000280	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
743718000281	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
743718000282	Response regulator receiver domain; Region: Response_reg; pfam00072
743718000283	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
743718000284	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
743718000285	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
743718000286	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
743718000287	ATP binding site [chemical binding]; other site
743718000288	Walker A motif; other site
743718000289	hexamer interface [polypeptide binding]; other site
743718000290	Walker B motif; other site
743718000291	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
743718000292	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
743718000293	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
743718000294	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
743718000295	PspC domain; Region: PspC; pfam04024
743718000296	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
743718000297	active site
743718000298	substrate binding site [chemical binding]; other site
743718000299	ATP binding site [chemical binding]; other site
743718000300	Phosphotransferase enzyme family; Region: APH; pfam01636
743718000301	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718000302	ATP binding site [chemical binding]; other site
743718000303	putative Mg++ binding site [ion binding]; other site
743718000304	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718000305	nucleotide binding region [chemical binding]; other site
743718000306	ATP-binding site [chemical binding]; other site
743718000307	Helicase associated domain (HA2); Region: HA2; pfam04408
743718000308	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
743718000309	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
743718000310	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
743718000311	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
743718000312	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
743718000313	oligomeric interface; other site
743718000314	putative active site [active]
743718000315	homodimer interface [polypeptide binding]; other site
743718000316	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
743718000317	putative active site [active]
743718000318	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
743718000319	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
743718000320	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
743718000321	putative deacylase active site [active]
743718000322	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718000323	anti sigma factor interaction site; other site
743718000324	regulatory phosphorylation site [posttranslational modification]; other site
743718000325	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718000326	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718000327	DNA binding site [nucleotide binding]
743718000328	domain linker motif; other site
743718000329	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718000330	dimerization interface [polypeptide binding]; other site
743718000331	ligand binding site [chemical binding]; other site
743718000332	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718000333	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718000334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000335	dimer interface [polypeptide binding]; other site
743718000336	conserved gate region; other site
743718000337	putative PBP binding loops; other site
743718000338	ABC-ATPase subunit interface; other site
743718000339	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718000340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000341	dimer interface [polypeptide binding]; other site
743718000342	conserved gate region; other site
743718000343	putative PBP binding loops; other site
743718000344	ABC-ATPase subunit interface; other site
743718000345	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
743718000346	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
743718000347	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
743718000348	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
743718000349	FAD binding domain; Region: FAD_binding_4; pfam01565
743718000350	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
743718000351	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
743718000352	Na2 binding site [ion binding]; other site
743718000353	putative substrate binding site 1 [chemical binding]; other site
743718000354	Na binding site 1 [ion binding]; other site
743718000355	putative substrate binding site 2 [chemical binding]; other site
743718000356	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
743718000357	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
743718000358	substrate binding pocket [chemical binding]; other site
743718000359	membrane-bound complex binding site; other site
743718000360	hinge residues; other site
743718000361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000362	dimer interface [polypeptide binding]; other site
743718000363	conserved gate region; other site
743718000364	putative PBP binding loops; other site
743718000365	ABC-ATPase subunit interface; other site
743718000366	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
743718000367	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
743718000368	Walker A/P-loop; other site
743718000369	ATP binding site [chemical binding]; other site
743718000370	Q-loop/lid; other site
743718000371	ABC transporter signature motif; other site
743718000372	Walker B; other site
743718000373	D-loop; other site
743718000374	H-loop/switch region; other site
743718000375	Excalibur calcium-binding domain; Region: Excalibur; smart00894
743718000376	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
743718000377	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
743718000378	Part of AAA domain; Region: AAA_19; pfam13245
743718000379	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
743718000380	AAA domain; Region: AAA_12; pfam13087
743718000381	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743718000382	DNA-binding site [nucleotide binding]; DNA binding site
743718000383	RNA-binding motif; other site
743718000384	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718000385	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718000386	active site
743718000387	catalytic tetrad [active]
743718000388	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
743718000389	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
743718000390	ligand binding site [chemical binding]; other site
743718000391	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
743718000392	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
743718000393	putative active site [active]
743718000394	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
743718000395	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
743718000396	Walker A/P-loop; other site
743718000397	ATP binding site [chemical binding]; other site
743718000398	Q-loop/lid; other site
743718000399	ABC transporter signature motif; other site
743718000400	Walker B; other site
743718000401	D-loop; other site
743718000402	H-loop/switch region; other site
743718000403	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
743718000404	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
743718000405	Walker A/P-loop; other site
743718000406	ATP binding site [chemical binding]; other site
743718000407	Q-loop/lid; other site
743718000408	ABC transporter signature motif; other site
743718000409	Walker B; other site
743718000410	D-loop; other site
743718000411	H-loop/switch region; other site
743718000412	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
743718000413	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
743718000414	TM-ABC transporter signature motif; other site
743718000415	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
743718000416	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718000417	TM-ABC transporter signature motif; other site
743718000418	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
743718000419	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718000420	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
743718000421	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743718000422	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
743718000423	Activator of Hsp90 ATPase homolog 1-like protein; Region: AHSA1; pfam08327
743718000424	hydrophobic ligand binding site; other site
743718000425	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
743718000426	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
743718000427	tetramer interface [polypeptide binding]; other site
743718000428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000429	catalytic residue [active]
743718000430	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
743718000431	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743718000432	dimer interface [polypeptide binding]; other site
743718000433	active site
743718000434	CoA binding pocket [chemical binding]; other site
743718000435	haloalkane dehalogenase; Provisional; Region: PRK03204
743718000436	peptide synthase; Provisional; Region: PRK09274
743718000437	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
743718000438	acyl-activating enzyme (AAE) consensus motif; other site
743718000439	AMP binding site [chemical binding]; other site
743718000440	active site
743718000441	CoA binding site [chemical binding]; other site
743718000442	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743718000443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718000444	NAD(P) binding site [chemical binding]; other site
743718000445	active site
743718000446	Family description; Region: UvrD_C_2; pfam13538
743718000447	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
743718000448	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743718000449	putative metal binding site [ion binding]; other site
743718000450	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
743718000451	SEC-C motif; Region: SEC-C; pfam02810
743718000452	hypothetical protein; Provisional; Region: PRK01842
743718000453	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
743718000454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718000455	putative substrate translocation pore; other site
743718000456	hypothetical protein; Provisional; Region: PRK02237
743718000457	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
743718000458	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718000459	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
743718000460	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718000461	substrate binding site [chemical binding]; other site
743718000462	dimer interface [polypeptide binding]; other site
743718000463	ATP binding site [chemical binding]; other site
743718000464	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
743718000465	additional DNA contacts [nucleotide binding]; other site
743718000466	active site
743718000467	zinc binding site [ion binding]; other site
743718000468	DNA intercalation site [nucleotide binding]; other site
743718000469	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
743718000470	cofactor binding site; other site
743718000471	DNA binding site [nucleotide binding]
743718000472	substrate interaction site [chemical binding]; other site
743718000473	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
743718000474	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
743718000475	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743718000476	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743718000477	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
743718000478	TIGR03086 family protein; Region: TIGR03086
743718000479	Helix-turn-helix domain; Region: HTH_18; pfam12833
743718000480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743718000481	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
743718000482	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743718000483	DNA binding residues [nucleotide binding]
743718000484	dimer interface [polypeptide binding]; other site
743718000485	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
743718000486	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
743718000487	active site
743718000488	catalytic triad [active]
743718000489	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743718000490	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743718000491	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743718000492	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
743718000493	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
743718000494	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
743718000495	Walker A/P-loop; other site
743718000496	ATP binding site [chemical binding]; other site
743718000497	Q-loop/lid; other site
743718000498	ABC transporter signature motif; other site
743718000499	Walker B; other site
743718000500	D-loop; other site
743718000501	H-loop/switch region; other site
743718000502	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
743718000503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000504	dimer interface [polypeptide binding]; other site
743718000505	conserved gate region; other site
743718000506	putative PBP binding loops; other site
743718000507	ABC-ATPase subunit interface; other site
743718000508	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
743718000509	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
743718000510	substrate binding pocket [chemical binding]; other site
743718000511	membrane-bound complex binding site; other site
743718000512	hinge residues; other site
743718000513	Predicted flavoprotein [General function prediction only]; Region: COG0431
743718000514	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743718000515	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
743718000516	Predicted esterase [General function prediction only]; Region: COG0400
743718000517	Domain of unknown function (DUF336); Region: DUF336; cl01249
743718000518	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743718000519	active site
743718000520	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
743718000521	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743718000522	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
743718000523	active site
743718000524	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
743718000525	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
743718000526	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
743718000527	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
743718000528	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
743718000529	tetramer interface [polypeptide binding]; other site
743718000530	active site
743718000531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718000532	dimerization interface [polypeptide binding]; other site
743718000533	putative DNA binding site [nucleotide binding]; other site
743718000534	putative Zn2+ binding site [ion binding]; other site
743718000535	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
743718000536	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
743718000537	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718000538	amino acid transporter; Region: 2A0306; TIGR00909
743718000539	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
743718000540	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743718000541	Low molecular weight phosphatase family; Region: LMWPc; cd00115
743718000542	active site
743718000543	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718000544	putative DNA binding site [nucleotide binding]; other site
743718000545	putative Zn2+ binding site [ion binding]; other site
743718000546	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743718000547	Low molecular weight phosphatase family; Region: LMWPc; cl00105
743718000548	active site
743718000549	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
743718000550	arsenical-resistance protein; Region: acr3; TIGR00832
743718000551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718000552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718000553	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718000554	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718000555	Walker A/P-loop; other site
743718000556	ATP binding site [chemical binding]; other site
743718000557	Q-loop/lid; other site
743718000558	ABC transporter signature motif; other site
743718000559	Walker B; other site
743718000560	D-loop; other site
743718000561	H-loop/switch region; other site
743718000562	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
743718000563	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
743718000564	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
743718000565	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
743718000566	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
743718000567	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718000568	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
743718000569	homodimer interface [polypeptide binding]; other site
743718000570	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718000571	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718000572	active site
743718000573	Bacterial PH domain; Region: DUF304; pfam03703
743718000574	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718000575	catalytic core [active]
743718000576	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
743718000577	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
743718000578	catalytic residues [active]
743718000579	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
743718000580	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
743718000581	minor groove reading motif; other site
743718000582	helix-hairpin-helix signature motif; other site
743718000583	active site
743718000584	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
743718000585	RNA/DNA hybrid binding site [nucleotide binding]; other site
743718000586	active site
743718000587	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
743718000588	diiron binding motif [ion binding]; other site
743718000589	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
743718000590	Predicted acetyltransferase [General function prediction only]; Region: COG2388
743718000591	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718000592	Coenzyme A binding pocket [chemical binding]; other site
743718000593	phosphoglucomutase; Validated; Region: PRK07564
743718000594	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
743718000595	active site
743718000596	substrate binding site [chemical binding]; other site
743718000597	metal binding site [ion binding]; metal-binding site
743718000598	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743718000599	active site residue [active]
743718000600	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
743718000601	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
743718000602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718000603	NAD(P) binding site [chemical binding]; other site
743718000604	active site
743718000605	adenylosuccinate lyase; Provisional; Region: PRK09285
743718000606	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
743718000607	tetramer interface [polypeptide binding]; other site
743718000608	active site
743718000609	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
743718000610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718000611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000612	homodimer interface [polypeptide binding]; other site
743718000613	catalytic residue [active]
743718000614	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
743718000615	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743718000616	NAD(P) binding site [chemical binding]; other site
743718000617	putative active site [active]
743718000618	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
743718000619	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
743718000620	DNA binding residues [nucleotide binding]
743718000621	dimer interface [polypeptide binding]; other site
743718000622	[2Fe-2S] cluster binding site [ion binding]; other site
743718000623	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
743718000624	TPP-binding site [chemical binding]; other site
743718000625	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743718000626	PYR/PP interface [polypeptide binding]; other site
743718000627	dimer interface [polypeptide binding]; other site
743718000628	TPP binding site [chemical binding]; other site
743718000629	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
743718000630	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718000631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718000632	dimer interface [polypeptide binding]; other site
743718000633	conserved gate region; other site
743718000634	putative PBP binding loops; other site
743718000635	ABC-ATPase subunit interface; other site
743718000636	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718000637	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
743718000638	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743718000639	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
743718000640	active site
743718000641	catalytic site [active]
743718000642	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
743718000643	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
743718000644	tetramer interface [polypeptide binding]; other site
743718000645	TPP-binding site [chemical binding]; other site
743718000646	heterodimer interface [polypeptide binding]; other site
743718000647	phosphorylation loop region [posttranslational modification]
743718000648	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
743718000649	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
743718000650	alpha subunit interface [polypeptide binding]; other site
743718000651	TPP binding site [chemical binding]; other site
743718000652	heterodimer interface [polypeptide binding]; other site
743718000653	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743718000654	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
743718000655	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743718000656	E3 interaction surface; other site
743718000657	lipoyl attachment site [posttranslational modification]; other site
743718000658	e3 binding domain; Region: E3_binding; pfam02817
743718000659	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743718000660	Copper resistance protein D; Region: CopD; pfam05425
743718000661	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
743718000662	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
743718000663	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743718000664	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718000665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718000666	MMPL family; Region: MMPL; pfam03176
743718000667	MMPL family; Region: MMPL; pfam03176
743718000668	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
743718000669	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
743718000670	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
743718000671	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743718000672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743718000673	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743718000674	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718000675	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718000676	active site
743718000677	catalytic tetrad [active]
743718000678	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
743718000679	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
743718000680	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743718000681	Strictosidine synthase; Region: Str_synth; pfam03088
743718000682	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
743718000683	active site
743718000684	homotetramer interface [polypeptide binding]; other site
743718000685	homodimer interface [polypeptide binding]; other site
743718000686	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718000687	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743718000688	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
743718000689	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718000690	motif II; other site
743718000691	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718000692	dimerization interface [polypeptide binding]; other site
743718000693	putative DNA binding site [nucleotide binding]; other site
743718000694	putative Zn2+ binding site [ion binding]; other site
743718000695	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743718000696	putative hydrophobic ligand binding site [chemical binding]; other site
743718000697	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743718000698	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
743718000699	HPr interaction site; other site
743718000700	glycerol kinase (GK) interaction site [polypeptide binding]; other site
743718000701	active site
743718000702	phosphorylation site [posttranslational modification]
743718000703	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
743718000704	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
743718000705	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
743718000706	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
743718000707	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
743718000708	dimerization domain swap beta strand [polypeptide binding]; other site
743718000709	regulatory protein interface [polypeptide binding]; other site
743718000710	active site
743718000711	regulatory phosphorylation site [posttranslational modification]; other site
743718000712	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
743718000713	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718000714	DNA interaction; other site
743718000715	Metal-binding active site; metal-binding site
743718000716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718000717	Salmonella virulence-associated 28kDa protein; Region: VRP3; cl04142
743718000718	DinB superfamily; Region: DinB_2; pfam12867
743718000719	Pirin-related protein [General function prediction only]; Region: COG1741
743718000720	Pirin; Region: Pirin; pfam02678
743718000721	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
743718000722	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
743718000723	trimer interface [polypeptide binding]; other site
743718000724	active site
743718000725	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
743718000726	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743718000727	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
743718000728	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
743718000729	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
743718000730	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
743718000731	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
743718000732	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743718000733	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
743718000734	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
743718000735	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
743718000736	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
743718000737	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743718000738	DNA binding site [nucleotide binding]
743718000739	active site
743718000740	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
743718000741	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
743718000742	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743718000743	AlkA N-terminal domain; Region: AlkA_N; cl05528
743718000744	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
743718000745	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743718000746	minor groove reading motif; other site
743718000747	helix-hairpin-helix signature motif; other site
743718000748	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
743718000749	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743718000750	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
743718000751	Clp amino terminal domain; Region: Clp_N; pfam02861
743718000752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718000753	Walker A motif; other site
743718000754	ATP binding site [chemical binding]; other site
743718000755	Walker B motif; other site
743718000756	arginine finger; other site
743718000757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718000758	Walker A motif; other site
743718000759	ATP binding site [chemical binding]; other site
743718000760	Walker B motif; other site
743718000761	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
743718000762	Septum formation; Region: Septum_form; pfam13845
743718000763	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
743718000764	putative catalytic site [active]
743718000765	putative phosphate binding site [ion binding]; other site
743718000766	active site
743718000767	metal binding site A [ion binding]; metal-binding site
743718000768	DNA binding site [nucleotide binding]
743718000769	putative AP binding site [nucleotide binding]; other site
743718000770	putative metal binding site B [ion binding]; other site
743718000771	classical (c) SDRs; Region: SDR_c; cd05233
743718000772	NAD(P) binding site [chemical binding]; other site
743718000773	active site
743718000774	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718000775	active site
743718000776	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
743718000777	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718000778	active site
743718000779	motif I; other site
743718000780	motif II; other site
743718000781	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718000782	Domain of unknown function (DUF368); Region: DUF368; pfam04018
743718000783	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743718000784	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
743718000785	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
743718000786	active site
743718000787	intersubunit interface [polypeptide binding]; other site
743718000788	zinc binding site [ion binding]; other site
743718000789	Na+ binding site [ion binding]; other site
743718000790	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718000791	anti sigma factor interaction site; other site
743718000792	regulatory phosphorylation site [posttranslational modification]; other site
743718000793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743718000794	PAS domain; Region: PAS_9; pfam13426
743718000795	putative active site [active]
743718000796	heme pocket [chemical binding]; other site
743718000797	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718000798	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
743718000799	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
743718000800	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
743718000801	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718000802	anti sigma factor interaction site; other site
743718000803	regulatory phosphorylation site [posttranslational modification]; other site
743718000804	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
743718000805	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
743718000806	GDP-binding site [chemical binding]; other site
743718000807	ACT binding site; other site
743718000808	IMP binding site; other site
743718000809	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
743718000810	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
743718000811	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
743718000812	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
743718000813	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
743718000814	ATP binding site [chemical binding]; other site
743718000815	active site
743718000816	substrate binding site [chemical binding]; other site
743718000817	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743718000818	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743718000819	ligand binding site [chemical binding]; other site
743718000820	flexible hinge region; other site
743718000821	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743718000822	putative switch regulator; other site
743718000823	non-specific DNA interactions [nucleotide binding]; other site
743718000824	DNA binding site [nucleotide binding]
743718000825	sequence specific DNA binding site [nucleotide binding]; other site
743718000826	putative cAMP binding site [chemical binding]; other site
743718000827	Cna protein B-type domain; Region: Cna_B; pfam05738
743718000828	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
743718000829	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
743718000830	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
743718000831	putative active site [active]
743718000832	catalytic triad [active]
743718000833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718000834	Coenzyme A binding pocket [chemical binding]; other site
743718000835	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
743718000836	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
743718000837	putative active site [active]
743718000838	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
743718000839	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
743718000840	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743718000841	homodimer interface [polypeptide binding]; other site
743718000842	substrate-cofactor binding pocket; other site
743718000843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718000844	catalytic residue [active]
743718000845	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
743718000846	active site residue [active]
743718000847	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
743718000848	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743718000849	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718000850	catalytic residue [active]
743718000851	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
743718000852	Amidase; Region: Amidase; cl11426
743718000853	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
743718000854	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
743718000855	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718000856	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
743718000857	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
743718000858	active site 2 [active]
743718000859	active site 1 [active]
743718000860	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
743718000861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718000862	NAD(P) binding site [chemical binding]; other site
743718000863	active site
743718000864	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
743718000865	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
743718000866	dimer interface [polypeptide binding]; other site
743718000867	active site
743718000868	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718000869	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743718000870	acyl-coenzyme A oxidase; Region: PLN02636
743718000871	active site
743718000872	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
743718000873	EamA-like transporter family; Region: EamA; pfam00892
743718000874	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
743718000875	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
743718000876	dimerization interface [polypeptide binding]; other site
743718000877	ATP binding site [chemical binding]; other site
743718000878	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
743718000879	dimerization interface [polypeptide binding]; other site
743718000880	ATP binding site [chemical binding]; other site
743718000881	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
743718000882	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
743718000883	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
743718000884	RNB domain; Region: RNB; pfam00773
743718000885	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
743718000886	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
743718000887	generic binding surface I; other site
743718000888	generic binding surface II; other site
743718000889	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
743718000890	putative active site [active]
743718000891	putative catalytic site [active]
743718000892	putative Mg binding site IVb [ion binding]; other site
743718000893	putative phosphate binding site [ion binding]; other site
743718000894	putative DNA binding site [nucleotide binding]; other site
743718000895	putative Mg binding site IVa [ion binding]; other site
743718000896	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
743718000897	aromatic chitin/cellulose binding site residues [chemical binding]; other site
743718000898	amidophosphoribosyltransferase; Provisional; Region: PRK07847
743718000899	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
743718000900	active site
743718000901	tetramer interface [polypeptide binding]; other site
743718000902	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718000903	active site
743718000904	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
743718000905	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
743718000906	dimerization interface [polypeptide binding]; other site
743718000907	putative ATP binding site [chemical binding]; other site
743718000908	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
743718000909	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
743718000910	DNA binding residues [nucleotide binding]
743718000911	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
743718000912	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
743718000913	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
743718000914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
743718000915	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743718000916	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743718000917	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
743718000918	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
743718000919	active site
743718000920	catalytic site [active]
743718000921	RibD C-terminal domain; Region: RibD_C; cl17279
743718000922	Uncharacterized conserved protein [Function unknown]; Region: COG4127
743718000923	Restriction endonuclease; Region: Mrr_cat; pfam04471
743718000924	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
743718000925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718000926	Walker A/P-loop; other site
743718000927	ATP binding site [chemical binding]; other site
743718000928	Q-loop/lid; other site
743718000929	ABC transporter signature motif; other site
743718000930	Walker B; other site
743718000931	D-loop; other site
743718000932	H-loop/switch region; other site
743718000933	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
743718000934	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
743718000935	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
743718000936	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718000937	ATP binding site [chemical binding]; other site
743718000938	putative Mg++ binding site [ion binding]; other site
743718000939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718000940	nucleotide binding region [chemical binding]; other site
743718000941	ATP-binding site [chemical binding]; other site
743718000942	methionine sulfoxide reductase B; Provisional; Region: PRK00222
743718000943	SelR domain; Region: SelR; pfam01641
743718000944	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743718000945	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718000946	putative DNA binding site [nucleotide binding]; other site
743718000947	MarR family; Region: MarR_2; cl17246
743718000948	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718000949	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718000950	active site
743718000951	catalytic tetrad [active]
743718000952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718000953	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743718000954	putative substrate translocation pore; other site
743718000955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718000956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718000957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718000958	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
743718000959	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
743718000960	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
743718000961	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
743718000962	active site
743718000963	Ap6A binding site [chemical binding]; other site
743718000964	nudix motif; other site
743718000965	metal binding site [ion binding]; metal-binding site
743718000966	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718000967	catalytic core [active]
743718000968	polyphosphate kinase; Provisional; Region: PRK05443
743718000969	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
743718000970	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
743718000971	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
743718000972	putative domain interface [polypeptide binding]; other site
743718000973	putative active site [active]
743718000974	catalytic site [active]
743718000975	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
743718000976	putative active site [active]
743718000977	catalytic site [active]
743718000978	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
743718000979	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718000980	Coenzyme A binding pocket [chemical binding]; other site
743718000981	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718000982	Coenzyme A binding pocket [chemical binding]; other site
743718000983	acetyl-CoA synthetase; Provisional; Region: PRK00174
743718000984	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
743718000985	active site
743718000986	CoA binding site [chemical binding]; other site
743718000987	acyl-activating enzyme (AAE) consensus motif; other site
743718000988	AMP binding site [chemical binding]; other site
743718000989	acetate binding site [chemical binding]; other site
743718000990	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
743718000991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718000992	motif II; other site
743718000993	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718000994	putative DNA binding site [nucleotide binding]; other site
743718000995	dimerization interface [polypeptide binding]; other site
743718000996	putative Zn2+ binding site [ion binding]; other site
743718000997	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
743718000998	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
743718000999	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
743718001000	ATP binding site [chemical binding]; other site
743718001001	Walker A motif; other site
743718001002	hexamer interface [polypeptide binding]; other site
743718001003	Walker B motif; other site
743718001004	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
743718001005	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
743718001006	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
743718001007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718001008	ATP binding site [chemical binding]; other site
743718001009	putative Mg++ binding site [ion binding]; other site
743718001010	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
743718001011	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
743718001012	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
743718001013	active site
743718001014	metal binding site [ion binding]; metal-binding site
743718001015	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
743718001016	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718001017	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718001018	DNA binding residues [nucleotide binding]
743718001019	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
743718001020	DTAP/Switch II; other site
743718001021	Switch I; other site
743718001022	Carbon starvation protein CstA; Region: CstA; pfam02554
743718001023	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
743718001024	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
743718001025	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
743718001026	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
743718001027	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743718001028	Protein of unknown function (DUF419); Region: DUF419; pfam04237
743718001029	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743718001030	active site
743718001031	Zn binding site [ion binding]; other site
743718001032	Cupin domain; Region: Cupin_2; cl17218
743718001033	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743718001034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718001035	S-adenosylmethionine binding site [chemical binding]; other site
743718001036	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
743718001037	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718001038	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718001039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718001040	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718001041	Trypsin; Region: Trypsin; pfam00089
743718001042	Beta-lactamase; Region: Beta-lactamase; pfam00144
743718001043	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743718001044	PAP2 superfamily; Region: PAP2; pfam01569
743718001045	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001046	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001047	DNA binding site [nucleotide binding]
743718001048	domain linker motif; other site
743718001049	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
743718001050	putative dimerization interface [polypeptide binding]; other site
743718001051	putative ligand binding site [chemical binding]; other site
743718001052	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
743718001053	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
743718001054	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743718001055	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
743718001056	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
743718001057	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718001058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001059	dimer interface [polypeptide binding]; other site
743718001060	conserved gate region; other site
743718001061	putative PBP binding loops; other site
743718001062	ABC-ATPase subunit interface; other site
743718001063	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718001064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001065	dimer interface [polypeptide binding]; other site
743718001066	conserved gate region; other site
743718001067	putative PBP binding loops; other site
743718001068	ABC-ATPase subunit interface; other site
743718001069	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
743718001070	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
743718001071	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
743718001072	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
743718001073	aromatic chitin/cellulose binding site residues [chemical binding]; other site
743718001074	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
743718001075	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
743718001076	active site
743718001077	interdomain interaction site; other site
743718001078	putative metal-binding site [ion binding]; other site
743718001079	nucleotide binding site [chemical binding]; other site
743718001080	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
743718001081	domain I; other site
743718001082	phosphate binding site [ion binding]; other site
743718001083	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
743718001084	domain II; other site
743718001085	domain III; other site
743718001086	nucleotide binding site [chemical binding]; other site
743718001087	DNA binding groove [nucleotide binding]
743718001088	catalytic site [active]
743718001089	domain IV; other site
743718001090	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743718001091	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743718001092	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743718001093	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743718001094	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743718001095	MarR family; Region: MarR; pfam01047
743718001096	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718001097	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718001098	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743718001099	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
743718001100	thymidylate kinase; Validated; Region: tmk; PRK00698
743718001101	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
743718001102	TMP-binding site; other site
743718001103	ATP-binding site [chemical binding]; other site
743718001104	DNA polymerase III subunit delta'; Validated; Region: PRK07940
743718001105	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
743718001106	DNA polymerase III subunit delta'; Validated; Region: PRK08485
743718001107	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
743718001108	putative active site [active]
743718001109	putative substrate binding site [chemical binding]; other site
743718001110	putative cosubstrate binding site; other site
743718001111	catalytic site [active]
743718001112	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
743718001113	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
743718001114	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743718001115	substrate binding site [chemical binding]; other site
743718001116	oxyanion hole (OAH) forming residues; other site
743718001117	trimer interface [polypeptide binding]; other site
743718001118	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
743718001119	TAP-like protein; Region: Abhydrolase_4; pfam08386
743718001120	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743718001121	active site
743718001122	metal binding site [ion binding]; metal-binding site
743718001123	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743718001124	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
743718001125	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
743718001126	AMP-binding enzyme; Region: AMP-binding; pfam00501
743718001127	active site
743718001128	CoA binding site [chemical binding]; other site
743718001129	AMP binding site [chemical binding]; other site
743718001130	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743718001131	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
743718001132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718001133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001134	ABC-ATPase subunit interface; other site
743718001135	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
743718001136	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718001137	Walker A/P-loop; other site
743718001138	ATP binding site [chemical binding]; other site
743718001139	Q-loop/lid; other site
743718001140	ABC transporter signature motif; other site
743718001141	Walker B; other site
743718001142	D-loop; other site
743718001143	H-loop/switch region; other site
743718001144	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
743718001145	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
743718001146	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
743718001147	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743718001148	active site
743718001149	ATP binding site [chemical binding]; other site
743718001150	substrate binding site [chemical binding]; other site
743718001151	activation loop (A-loop); other site
743718001152	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743718001153	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743718001154	Walker A/P-loop; other site
743718001155	ATP binding site [chemical binding]; other site
743718001156	Q-loop/lid; other site
743718001157	ABC transporter signature motif; other site
743718001158	Walker B; other site
743718001159	D-loop; other site
743718001160	H-loop/switch region; other site
743718001161	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
743718001162	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
743718001163	active site
743718001164	catalytic residues [active]
743718001165	metal binding site [ion binding]; metal-binding site
743718001166	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
743718001167	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
743718001168	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
743718001169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
743718001170	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718001171	Ligand Binding Site [chemical binding]; other site
743718001172	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
743718001173	Clp amino terminal domain; Region: Clp_N; pfam02861
743718001174	Clp amino terminal domain; Region: Clp_N; pfam02861
743718001175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718001176	Walker A motif; other site
743718001177	ATP binding site [chemical binding]; other site
743718001178	Walker B motif; other site
743718001179	arginine finger; other site
743718001180	UvrB/uvrC motif; Region: UVR; pfam02151
743718001181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718001182	Walker A motif; other site
743718001183	ATP binding site [chemical binding]; other site
743718001184	Walker B motif; other site
743718001185	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
743718001186	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
743718001187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718001188	motif II; other site
743718001189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718001190	NAD(P) binding site [chemical binding]; other site
743718001191	active site
743718001192	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743718001193	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
743718001194	Bacterial transcriptional regulator; Region: IclR; pfam01614
743718001195	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
743718001196	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
743718001197	active site
743718001198	intersubunit interface [polypeptide binding]; other site
743718001199	catalytic residue [active]
743718001200	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718001201	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
743718001202	substrate binding site [chemical binding]; other site
743718001203	ATP binding site [chemical binding]; other site
743718001204	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001205	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001206	DNA binding site [nucleotide binding]
743718001207	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
743718001208	putative dimerization interface [polypeptide binding]; other site
743718001209	putative ligand binding site [chemical binding]; other site
743718001210	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718001211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001212	dimer interface [polypeptide binding]; other site
743718001213	conserved gate region; other site
743718001214	putative PBP binding loops; other site
743718001215	ABC-ATPase subunit interface; other site
743718001216	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718001217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001218	dimer interface [polypeptide binding]; other site
743718001219	conserved gate region; other site
743718001220	putative PBP binding loops; other site
743718001221	ABC-ATPase subunit interface; other site
743718001222	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718001223	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
743718001224	Protein of unknown function, DUF624; Region: DUF624; pfam04854
743718001225	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
743718001226	Ferritin-like domain; Region: Ferritin; pfam00210
743718001227	ferroxidase diiron center [ion binding]; other site
743718001228	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
743718001229	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
743718001230	glucuronate isomerase; Reviewed; Region: PRK02925
743718001231	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
743718001232	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001233	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001234	DNA binding site [nucleotide binding]
743718001235	domain linker motif; other site
743718001236	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718001237	ligand binding site [chemical binding]; other site
743718001238	dimerization interface [polypeptide binding]; other site
743718001239	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
743718001240	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
743718001241	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
743718001242	trehalose synthase; Region: treS_nterm; TIGR02456
743718001243	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
743718001244	active site
743718001245	catalytic site [active]
743718001246	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
743718001247	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718001248	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718001249	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718001250	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718001251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001252	ABC-ATPase subunit interface; other site
743718001253	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718001254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001255	dimer interface [polypeptide binding]; other site
743718001256	conserved gate region; other site
743718001257	ABC-ATPase subunit interface; other site
743718001258	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
743718001259	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
743718001260	metal binding site [ion binding]; metal-binding site
743718001261	active site
743718001262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718001263	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718001264	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743718001265	Methane oxygenase PmoA; Region: PmoA; pfam14100
743718001266	Cupin domain; Region: Cupin_2; cl17218
743718001267	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
743718001268	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
743718001269	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743718001270	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
743718001271	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001273	DNA binding site [nucleotide binding]
743718001274	domain linker motif; other site
743718001275	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718001276	dimerization interface [polypeptide binding]; other site
743718001277	ligand binding site [chemical binding]; other site
743718001278	Domain of unknown function (DUF718); Region: DUF718; pfam05336
743718001279	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
743718001280	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
743718001281	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743718001282	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
743718001283	short chain dehydrogenase; Validated; Region: PRK08324
743718001284	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
743718001285	active site
743718001286	Zn2+ binding site [ion binding]; other site
743718001287	intersubunit interface [polypeptide binding]; other site
743718001288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718001289	NAD(P) binding site [chemical binding]; other site
743718001290	active site
743718001291	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743718001292	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
743718001293	nucleotide binding site [chemical binding]; other site
743718001294	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
743718001295	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
743718001296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718001297	Walker A/P-loop; other site
743718001298	ATP binding site [chemical binding]; other site
743718001299	Q-loop/lid; other site
743718001300	ABC transporter signature motif; other site
743718001301	Walker B; other site
743718001302	D-loop; other site
743718001303	H-loop/switch region; other site
743718001304	PAS fold; Region: PAS_2; pfam08446
743718001305	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
743718001306	Phytochrome region; Region: PHY; pfam00360
743718001307	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718001308	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
743718001309	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718001310	anti sigma factor interaction site; other site
743718001311	regulatory phosphorylation site [posttranslational modification]; other site
743718001312	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743718001313	Protein of unknown function (DUF993); Region: DUF993; pfam06187
743718001314	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718001315	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718001316	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001317	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001318	DNA binding site [nucleotide binding]
743718001319	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718001320	ligand binding site [chemical binding]; other site
743718001321	dimerization interface [polypeptide binding]; other site
743718001322	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718001323	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718001324	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743718001325	active site
743718001326	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
743718001327	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
743718001328	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
743718001329	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
743718001330	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
743718001331	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743718001332	Cysteine-rich domain; Region: CCG; pfam02754
743718001333	Cysteine-rich domain; Region: CCG; pfam02754
743718001334	Transcriptional regulators [Transcription]; Region: FadR; COG2186
743718001335	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718001336	DNA-binding site [nucleotide binding]; DNA binding site
743718001337	FCD domain; Region: FCD; cl11656
743718001338	SprT-like family; Region: SprT-like; pfam10263
743718001339	SprT homologues; Region: SprT; cl01182
743718001340	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
743718001341	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743718001342	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
743718001343	dimer interface [polypeptide binding]; other site
743718001344	active site
743718001345	CoA binding pocket [chemical binding]; other site
743718001346	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718001347	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718001348	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743718001349	Amb_all domain; Region: Amb_all; smart00656
743718001350	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718001351	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718001352	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001353	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001354	DNA binding site [nucleotide binding]
743718001355	domain linker motif; other site
743718001356	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718001357	dimerization interface [polypeptide binding]; other site
743718001358	ligand binding site [chemical binding]; other site
743718001359	Methane oxygenase PmoA; Region: PmoA; pfam14100
743718001360	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718001361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001362	dimer interface [polypeptide binding]; other site
743718001363	putative PBP binding loops; other site
743718001364	ABC-ATPase subunit interface; other site
743718001365	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718001366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718001367	dimer interface [polypeptide binding]; other site
743718001368	conserved gate region; other site
743718001369	ABC-ATPase subunit interface; other site
743718001370	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718001371	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718001372	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
743718001373	galactarate dehydratase; Region: galactar-dH20; TIGR03248
743718001374	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
743718001375	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718001376	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718001377	active site
743718001378	catalytic tetrad [active]
743718001379	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743718001380	substrate binding site [chemical binding]; other site
743718001381	ATP binding site [chemical binding]; other site
743718001382	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
743718001383	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743718001384	active site
743718001385	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743718001386	AsnC family; Region: AsnC_trans_reg; pfam01037
743718001387	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
743718001388	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
743718001389	tetramer interface [polypeptide binding]; other site
743718001390	TPP-binding site [chemical binding]; other site
743718001391	heterodimer interface [polypeptide binding]; other site
743718001392	phosphorylation loop region [posttranslational modification]
743718001393	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
743718001394	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
743718001395	alpha subunit interface [polypeptide binding]; other site
743718001396	TPP binding site [chemical binding]; other site
743718001397	heterodimer interface [polypeptide binding]; other site
743718001398	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743718001399	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
743718001400	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743718001401	E3 interaction surface; other site
743718001402	lipoyl attachment site [posttranslational modification]; other site
743718001403	e3 binding domain; Region: E3_binding; pfam02817
743718001404	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743718001405	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
743718001406	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
743718001407	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
743718001408	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
743718001409	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743718001410	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743718001411	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
743718001412	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
743718001413	carboxyltransferase (CT) interaction site; other site
743718001414	biotinylation site [posttranslational modification]; other site
743718001415	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743718001416	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743718001417	active site
743718001418	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
743718001419	putative active site [active]
743718001420	putative catalytic site [active]
743718001421	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
743718001422	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718001423	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
743718001424	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
743718001425	active site
743718001426	substrate-binding site [chemical binding]; other site
743718001427	metal-binding site [ion binding]
743718001428	GTP binding site [chemical binding]; other site
743718001429	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743718001430	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718001431	non-specific DNA binding site [nucleotide binding]; other site
743718001432	salt bridge; other site
743718001433	sequence-specific DNA binding site [nucleotide binding]; other site
743718001434	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
743718001435	Domain of unknown function (DUF955); Region: DUF955; cl01076
743718001436	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
743718001437	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
743718001438	glycerol kinase; Provisional; Region: glpK; PRK00047
743718001439	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
743718001440	N- and C-terminal domain interface [polypeptide binding]; other site
743718001441	active site
743718001442	MgATP binding site [chemical binding]; other site
743718001443	catalytic site [active]
743718001444	metal binding site [ion binding]; metal-binding site
743718001445	putative homotetramer interface [polypeptide binding]; other site
743718001446	glycerol binding site [chemical binding]; other site
743718001447	homodimer interface [polypeptide binding]; other site
743718001448	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
743718001449	amphipathic channel; other site
743718001450	Asn-Pro-Ala signature motifs; other site
743718001451	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
743718001452	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
743718001453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718001454	DNA binding residues [nucleotide binding]
743718001455	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
743718001456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718001457	Coenzyme A binding pocket [chemical binding]; other site
743718001458	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
743718001459	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743718001460	minor groove reading motif; other site
743718001461	helix-hairpin-helix signature motif; other site
743718001462	substrate binding pocket [chemical binding]; other site
743718001463	active site
743718001464	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
743718001465	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
743718001466	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
743718001467	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
743718001468	Helix-hairpin-helix motif; Region: HHH; pfam00633
743718001469	DNA repair protein RadA; Provisional; Region: PRK11823
743718001470	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
743718001471	Walker A motif; other site
743718001472	ATP binding site [chemical binding]; other site
743718001473	Walker B motif; other site
743718001474	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
743718001475	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
743718001476	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
743718001477	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
743718001478	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
743718001479	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
743718001480	TrkA-N domain; Region: TrkA_N; pfam02254
743718001481	TrkA-C domain; Region: TrkA_C; pfam02080
743718001482	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
743718001483	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
743718001484	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
743718001485	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
743718001486	active site
743718001487	Zn binding site [ion binding]; other site
743718001488	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
743718001489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718001490	motif II; other site
743718001491	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
743718001492	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
743718001493	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
743718001494	CoA binding domain; Region: CoA_binding; smart00881
743718001495	Uncharacterized conserved protein [Function unknown]; Region: COG2353
743718001496	MarR family; Region: MarR_2; pfam12802
743718001497	Putative zinc-finger; Region: zf-HC2; pfam13490
743718001498	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718001499	catalytic core [active]
743718001500	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743718001501	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743718001502	catalytic residues [active]
743718001503	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
743718001504	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
743718001505	ResB-like family; Region: ResB; pfam05140
743718001506	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
743718001507	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
743718001508	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
743718001509	UbiA prenyltransferase family; Region: UbiA; pfam01040
743718001510	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
743718001511	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
743718001512	acyl-activating enzyme (AAE) consensus motif; other site
743718001513	active site
743718001514	AMP binding site [chemical binding]; other site
743718001515	CoA binding site [chemical binding]; other site
743718001516	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743718001517	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
743718001518	substrate binding site [chemical binding]; other site
743718001519	oxyanion hole (OAH) forming residues; other site
743718001520	trimer interface [polypeptide binding]; other site
743718001521	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
743718001522	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
743718001523	active site
743718001524	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
743718001525	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
743718001526	dimer interface [polypeptide binding]; other site
743718001527	tetramer interface [polypeptide binding]; other site
743718001528	PYR/PP interface [polypeptide binding]; other site
743718001529	TPP binding site [chemical binding]; other site
743718001530	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
743718001531	TPP-binding site; other site
743718001532	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743718001533	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
743718001534	protein binding site [polypeptide binding]; other site
743718001535	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
743718001536	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
743718001537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718001538	S-adenosylmethionine binding site [chemical binding]; other site
743718001539	YtxH-like protein; Region: YtxH; cl02079
743718001540	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
743718001541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743718001542	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
743718001543	NADH dehydrogenase subunit B; Validated; Region: PRK06411
743718001544	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
743718001545	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
743718001546	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
743718001547	NADH dehydrogenase subunit D; Validated; Region: PRK06075
743718001548	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
743718001549	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
743718001550	putative dimer interface [polypeptide binding]; other site
743718001551	[2Fe-2S] cluster binding site [ion binding]; other site
743718001552	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
743718001553	SLBB domain; Region: SLBB; pfam10531
743718001554	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
743718001555	NADH dehydrogenase subunit G; Validated; Region: PRK07860
743718001556	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743718001557	catalytic loop [active]
743718001558	iron binding site [ion binding]; other site
743718001559	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
743718001560	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
743718001561	molybdopterin cofactor binding site; other site
743718001562	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
743718001563	molybdopterin cofactor binding site; other site
743718001564	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
743718001565	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
743718001566	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
743718001567	4Fe-4S binding domain; Region: Fer4; pfam00037
743718001568	4Fe-4S binding domain; Region: Fer4; pfam00037
743718001569	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
743718001570	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
743718001571	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
743718001572	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
743718001573	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
743718001574	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743718001575	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
743718001576	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743718001577	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
743718001578	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743718001579	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
743718001580	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
743718001581	substrate binding pocket [chemical binding]; other site
743718001582	chain length determination region; other site
743718001583	substrate-Mg2+ binding site; other site
743718001584	catalytic residues [active]
743718001585	aspartate-rich region 1; other site
743718001586	active site lid residues [active]
743718001587	aspartate-rich region 2; other site
743718001588	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743718001589	Interdomain contacts; other site
743718001590	Cytokine receptor motif; other site
743718001591	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743718001592	Interdomain contacts; other site
743718001593	Cytokine receptor motif; other site
743718001594	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743718001595	Interdomain contacts; other site
743718001596	Cytokine receptor motif; other site
743718001597	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743718001598	Interdomain contacts; other site
743718001599	Cytokine receptor motif; other site
743718001600	MoxR-like ATPases [General function prediction only]; Region: COG0714
743718001601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718001602	Walker A motif; other site
743718001603	ATP binding site [chemical binding]; other site
743718001604	Walker B motif; other site
743718001605	arginine finger; other site
743718001606	Protein of unknown function DUF58; Region: DUF58; pfam01882
743718001607	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
743718001608	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
743718001609	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
743718001610	RDD family; Region: RDD; pfam06271
743718001611	FHA domain; Region: FHA; pfam00498
743718001612	phosphopeptide binding site; other site
743718001613	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
743718001614	active site
743718001615	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
743718001616	Protein kinase domain; Region: Pkinase; pfam00069
743718001617	Catalytic domain of Protein Kinases; Region: PKc; cd00180
743718001618	active site
743718001619	ATP binding site [chemical binding]; other site
743718001620	substrate binding site [chemical binding]; other site
743718001621	activation loop (A-loop); other site
743718001622	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
743718001623	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
743718001624	phosphopeptide binding site; other site
743718001625	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
743718001626	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
743718001627	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
743718001628	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
743718001629	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
743718001630	ferredoxin-NADP+ reductase; Region: PLN02852
743718001631	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743718001632	heat shock protein HtpX; Provisional; Region: PRK03072
743718001633	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
743718001634	metal binding site [ion binding]; metal-binding site
743718001635	active site
743718001636	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
743718001637	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718001638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
743718001639	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
743718001640	Predicted permeases [General function prediction only]; Region: RarD; COG2962
743718001641	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
743718001642	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
743718001643	active site
743718001644	catalytic site [active]
743718001645	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
743718001646	active site
743718001647	catalytic site [active]
743718001648	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
743718001649	ThiC-associated domain; Region: ThiC-associated; pfam13667
743718001650	ThiC family; Region: ThiC; pfam01964
743718001651	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743718001652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718001653	catalytic residue [active]
743718001654	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
743718001655	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743718001656	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
743718001657	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
743718001658	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
743718001659	IucA / IucC family; Region: IucA_IucC; pfam04183
743718001660	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
743718001661	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
743718001662	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
743718001663	active site
743718001664	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
743718001665	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
743718001666	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718001667	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718001668	DNA binding site [nucleotide binding]
743718001669	domain linker motif; other site
743718001670	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718001671	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
743718001672	FAD binding domain; Region: FAD_binding_4; pfam01565
743718001673	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
743718001674	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
743718001675	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
743718001676	Short C-terminal domain; Region: SHOCT; pfam09851
743718001677	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718001678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718001679	active site
743718001680	phosphorylation site [posttranslational modification]
743718001681	intermolecular recognition site; other site
743718001682	dimerization interface [polypeptide binding]; other site
743718001683	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718001684	DNA binding residues [nucleotide binding]
743718001685	dimerization interface [polypeptide binding]; other site
743718001686	Histidine kinase; Region: HisKA_3; pfam07730
743718001687	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
743718001688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
743718001689	adenosine deaminase; Provisional; Region: PRK09358
743718001690	active site
743718001691	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718001692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718001693	active site
743718001694	phosphorylation site [posttranslational modification]
743718001695	intermolecular recognition site; other site
743718001696	dimerization interface [polypeptide binding]; other site
743718001697	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718001698	DNA binding residues [nucleotide binding]
743718001699	dimerization interface [polypeptide binding]; other site
743718001700	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718001701	Histidine kinase; Region: HisKA_3; pfam07730
743718001702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718001703	ATP binding site [chemical binding]; other site
743718001704	Mg2+ binding site [ion binding]; other site
743718001705	G-X-G motif; other site
743718001706	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
743718001707	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
743718001708	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718001709	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718001710	Walker A/P-loop; other site
743718001711	ATP binding site [chemical binding]; other site
743718001712	Q-loop/lid; other site
743718001713	ABC transporter signature motif; other site
743718001714	Walker B; other site
743718001715	D-loop; other site
743718001716	H-loop/switch region; other site
743718001717	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
743718001718	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
743718001719	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
743718001720	putative homodimer interface [polypeptide binding]; other site
743718001721	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
743718001722	heterodimer interface [polypeptide binding]; other site
743718001723	homodimer interface [polypeptide binding]; other site
743718001724	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
743718001725	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
743718001726	23S rRNA interface [nucleotide binding]; other site
743718001727	L7/L12 interface [polypeptide binding]; other site
743718001728	putative thiostrepton binding site; other site
743718001729	L25 interface [polypeptide binding]; other site
743718001730	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
743718001731	mRNA/rRNA interface [nucleotide binding]; other site
743718001732	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743718001733	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
743718001734	active site
743718001735	catalytic residues [active]
743718001736	CHAT domain; Region: CHAT; pfam12770
743718001737	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
743718001738	23S rRNA interface [nucleotide binding]; other site
743718001739	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
743718001740	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
743718001741	core dimer interface [polypeptide binding]; other site
743718001742	peripheral dimer interface [polypeptide binding]; other site
743718001743	L10 interface [polypeptide binding]; other site
743718001744	L11 interface [polypeptide binding]; other site
743718001745	putative EF-Tu interaction site [polypeptide binding]; other site
743718001746	putative EF-G interaction site [polypeptide binding]; other site
743718001747	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
743718001748	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
743718001749	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
743718001750	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
743718001751	Peptidase family M23; Region: Peptidase_M23; pfam01551
743718001752	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
743718001753	RPB10 interaction site [polypeptide binding]; other site
743718001754	RPB1 interaction site [polypeptide binding]; other site
743718001755	RPB11 interaction site [polypeptide binding]; other site
743718001756	RPB3 interaction site [polypeptide binding]; other site
743718001757	RPB12 interaction site [polypeptide binding]; other site
743718001758	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
743718001759	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
743718001760	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
743718001761	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
743718001762	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
743718001763	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
743718001764	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
743718001765	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
743718001766	G-loop; other site
743718001767	DNA binding site [nucleotide binding]
743718001768	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
743718001769	S17 interaction site [polypeptide binding]; other site
743718001770	S8 interaction site; other site
743718001771	16S rRNA interaction site [nucleotide binding]; other site
743718001772	streptomycin interaction site [chemical binding]; other site
743718001773	23S rRNA interaction site [nucleotide binding]; other site
743718001774	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
743718001775	30S ribosomal protein S7; Validated; Region: PRK05302
743718001776	elongation factor G; Reviewed; Region: PRK00007
743718001777	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
743718001778	G1 box; other site
743718001779	putative GEF interaction site [polypeptide binding]; other site
743718001780	GTP/Mg2+ binding site [chemical binding]; other site
743718001781	Switch I region; other site
743718001782	G2 box; other site
743718001783	G3 box; other site
743718001784	Switch II region; other site
743718001785	G4 box; other site
743718001786	G5 box; other site
743718001787	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
743718001788	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
743718001789	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
743718001790	elongation factor Tu; Reviewed; Region: PRK00049
743718001791	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
743718001792	G1 box; other site
743718001793	GEF interaction site [polypeptide binding]; other site
743718001794	GTP/Mg2+ binding site [chemical binding]; other site
743718001795	Switch I region; other site
743718001796	G2 box; other site
743718001797	G3 box; other site
743718001798	Switch II region; other site
743718001799	G4 box; other site
743718001800	G5 box; other site
743718001801	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
743718001802	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
743718001803	Antibiotic Binding Site [chemical binding]; other site
743718001804	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
743718001805	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
743718001806	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
743718001807	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
743718001808	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
743718001809	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
743718001810	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
743718001811	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
743718001812	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
743718001813	putative translocon binding site; other site
743718001814	protein-rRNA interface [nucleotide binding]; other site
743718001815	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
743718001816	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
743718001817	G-X-X-G motif; other site
743718001818	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
743718001819	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
743718001820	23S rRNA interface [nucleotide binding]; other site
743718001821	5S rRNA interface [nucleotide binding]; other site
743718001822	putative antibiotic binding site [chemical binding]; other site
743718001823	L25 interface [polypeptide binding]; other site
743718001824	L27 interface [polypeptide binding]; other site
743718001825	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
743718001826	23S rRNA interface [nucleotide binding]; other site
743718001827	putative translocon interaction site; other site
743718001828	signal recognition particle (SRP54) interaction site; other site
743718001829	L23 interface [polypeptide binding]; other site
743718001830	trigger factor interaction site; other site
743718001831	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
743718001832	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
743718001833	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
743718001834	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
743718001835	RNA binding site [nucleotide binding]; other site
743718001836	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
743718001837	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
743718001838	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
743718001839	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
743718001840	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
743718001841	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
743718001842	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
743718001843	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
743718001844	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
743718001845	5S rRNA interface [nucleotide binding]; other site
743718001846	L27 interface [polypeptide binding]; other site
743718001847	23S rRNA interface [nucleotide binding]; other site
743718001848	L5 interface [polypeptide binding]; other site
743718001849	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
743718001850	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
743718001851	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
743718001852	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
743718001853	23S rRNA binding site [nucleotide binding]; other site
743718001854	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
743718001855	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
743718001856	SecY translocase; Region: SecY; pfam00344
743718001857	adenylate kinase; Reviewed; Region: adk; PRK00279
743718001858	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
743718001859	AMP-binding site [chemical binding]; other site
743718001860	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
743718001861	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
743718001862	active site
743718001863	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
743718001864	rRNA binding site [nucleotide binding]; other site
743718001865	predicted 30S ribosome binding site; other site
743718001866	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
743718001867	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
743718001868	30S ribosomal protein S13; Region: bact_S13; TIGR03631
743718001869	30S ribosomal protein S11; Validated; Region: PRK05309
743718001870	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
743718001871	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
743718001872	alphaNTD - beta interaction site [polypeptide binding]; other site
743718001873	alphaNTD homodimer interface [polypeptide binding]; other site
743718001874	alphaNTD - beta' interaction site [polypeptide binding]; other site
743718001875	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
743718001876	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
743718001877	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718001878	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718001879	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
743718001880	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
743718001881	dimerization interface 3.5A [polypeptide binding]; other site
743718001882	active site
743718001883	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
743718001884	23S rRNA interface [nucleotide binding]; other site
743718001885	L3 interface [polypeptide binding]; other site
743718001886	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
743718001887	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
743718001888	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
743718001889	active site
743718001890	substrate binding site [chemical binding]; other site
743718001891	metal binding site [ion binding]; metal-binding site
743718001892	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
743718001893	active site
743718001894	catalytic residues [active]
743718001895	metal binding site [ion binding]; metal-binding site
743718001896	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743718001897	pantothenate kinase; Provisional; Region: PRK05439
743718001898	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
743718001899	ATP-binding site [chemical binding]; other site
743718001900	CoA-binding site [chemical binding]; other site
743718001901	Mg2+-binding site [ion binding]; other site
743718001902	Protein of unknown function DUF72; Region: DUF72; pfam01904
743718001903	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
743718001904	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
743718001905	glutaminase active site [active]
743718001906	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
743718001907	dimer interface [polypeptide binding]; other site
743718001908	active site
743718001909	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
743718001910	dimer interface [polypeptide binding]; other site
743718001911	active site
743718001912	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
743718001913	metal binding site [ion binding]; metal-binding site
743718001914	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
743718001915	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
743718001916	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
743718001917	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
743718001918	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
743718001919	putative substrate binding site [chemical binding]; other site
743718001920	putative ATP binding site [chemical binding]; other site
743718001921	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743718001922	MarR family; Region: MarR_2; pfam12802
743718001923	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
743718001924	catalytic residues [active]
743718001925	dimer interface [polypeptide binding]; other site
743718001926	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
743718001927	active site
743718001928	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
743718001929	alanine racemase; Reviewed; Region: alr; PRK00053
743718001930	active site
743718001931	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743718001932	dimer interface [polypeptide binding]; other site
743718001933	substrate binding site [chemical binding]; other site
743718001934	catalytic residues [active]
743718001935	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
743718001936	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
743718001937	Glycoprotease family; Region: Peptidase_M22; pfam00814
743718001938	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
743718001939	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718001940	Coenzyme A binding pocket [chemical binding]; other site
743718001941	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
743718001942	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
743718001943	active site residue [active]
743718001944	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
743718001945	active site residue [active]
743718001946	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
743718001947	putative FMN binding site [chemical binding]; other site
743718001948	UGMP family protein; Validated; Region: PRK09604
743718001949	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
743718001950	carboxylate-amine ligase; Provisional; Region: PRK13517
743718001951	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
743718001952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718001953	S-adenosylmethionine binding site [chemical binding]; other site
743718001954	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
743718001955	oligomerisation interface [polypeptide binding]; other site
743718001956	mobile loop; other site
743718001957	roof hairpin; other site
743718001958	Transcription factor WhiB; Region: Whib; pfam02467
743718001959	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743718001960	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743718001961	DNA binding residues [nucleotide binding]
743718001962	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
743718001963	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743718001964	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
743718001965	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
743718001966	active site
743718001967	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
743718001968	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743718001969	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
743718001970	homotrimer interaction site [polypeptide binding]; other site
743718001971	putative active site [active]
743718001972	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743718001973	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
743718001974	active site
743718001975	catalytic site [active]
743718001976	substrate binding site [chemical binding]; other site
743718001977	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
743718001978	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743718001979	phosphate binding site [ion binding]; other site
743718001980	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
743718001981	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
743718001982	NAD(P) binding site [chemical binding]; other site
743718001983	catalytic residues [active]
743718001984	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
743718001985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
743718001986	Transcriptional regulators [Transcription]; Region: FadR; COG2186
743718001987	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
743718001988	DNA-binding site [nucleotide binding]; DNA binding site
743718001989	FCD domain; Region: FCD; pfam07729
743718001990	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
743718001991	ATP-binding site [chemical binding]; other site
743718001992	Gluconate-6-phosphate binding site [chemical binding]; other site
743718001993	Shikimate kinase; Region: SKI; pfam01202
743718001994	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
743718001995	fructuronate transporter; Provisional; Region: PRK10034; cl15264
743718001996	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
743718001997	propionate/acetate kinase; Provisional; Region: PRK12379
743718001998	phosphate acetyltransferase; Reviewed; Region: PRK05632
743718001999	DRTGG domain; Region: DRTGG; pfam07085
743718002000	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
743718002001	putative phosphoketolase; Provisional; Region: PRK05261
743718002002	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
743718002003	TPP-binding site; other site
743718002004	Src Homology 3 domain superfamily; Region: SH3; cl17036
743718002005	peptide ligand binding site [polypeptide binding]; other site
743718002006	XFP C-terminal domain; Region: XFP_C; pfam09363
743718002007	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
743718002008	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
743718002009	thiamine phosphate binding site [chemical binding]; other site
743718002010	active site
743718002011	pyrophosphate binding site [ion binding]; other site
743718002012	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
743718002013	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
743718002014	thiS-thiF/thiG interaction site; other site
743718002015	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
743718002016	ThiS interaction site; other site
743718002017	putative active site [active]
743718002018	tetramer interface [polypeptide binding]; other site
743718002019	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
743718002020	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
743718002021	ATP binding site [chemical binding]; other site
743718002022	substrate interface [chemical binding]; other site
743718002023	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
743718002024	active site residue [active]
743718002025	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718002026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718002027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002028	Walker A/P-loop; other site
743718002029	ATP binding site [chemical binding]; other site
743718002030	Q-loop/lid; other site
743718002031	ABC transporter signature motif; other site
743718002032	Walker B; other site
743718002033	D-loop; other site
743718002034	H-loop/switch region; other site
743718002035	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718002036	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718002037	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
743718002038	Q-loop/lid; other site
743718002039	ABC transporter signature motif; other site
743718002040	Walker B; other site
743718002041	D-loop; other site
743718002042	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
743718002043	GMP synthase; Reviewed; Region: guaA; PRK00074
743718002044	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
743718002045	AMP/PPi binding site [chemical binding]; other site
743718002046	candidate oxyanion hole; other site
743718002047	catalytic triad [active]
743718002048	potential glutamine specificity residues [chemical binding]; other site
743718002049	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
743718002050	ATP Binding subdomain [chemical binding]; other site
743718002051	Ligand Binding sites [chemical binding]; other site
743718002052	Dimerization subdomain; other site
743718002053	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718002054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718002055	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
743718002056	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
743718002057	PspC domain; Region: PspC; pfam04024
743718002058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718002059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718002060	ATP binding site [chemical binding]; other site
743718002061	Mg2+ binding site [ion binding]; other site
743718002062	G-X-G motif; other site
743718002063	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718002064	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718002065	DNA binding residues [nucleotide binding]
743718002066	dimerization interface [polypeptide binding]; other site
743718002067	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
743718002068	putative active site [active]
743718002069	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
743718002070	active site
743718002071	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
743718002072	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
743718002073	active site
743718002074	SAM binding site [chemical binding]; other site
743718002075	homodimer interface [polypeptide binding]; other site
743718002076	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
743718002077	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
743718002078	Active Sites [active]
743718002079	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
743718002080	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743718002081	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743718002082	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743718002083	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743718002084	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718002085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718002086	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
743718002087	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743718002088	DNA binding residues [nucleotide binding]
743718002089	drug binding residues [chemical binding]; other site
743718002090	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
743718002091	Part of AAA domain; Region: AAA_19; pfam13245
743718002092	Family description; Region: UvrD_C_2; pfam13538
743718002093	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718002094	Clp amino terminal domain; Region: Clp_N; pfam02861
743718002095	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
743718002096	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
743718002097	CoA-ligase; Region: Ligase_CoA; pfam00549
743718002098	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
743718002099	CoA binding domain; Region: CoA_binding; pfam02629
743718002100	CoA-ligase; Region: Ligase_CoA; pfam00549
743718002101	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
743718002102	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
743718002103	active site
743718002104	cosubstrate binding site; other site
743718002105	substrate binding site [chemical binding]; other site
743718002106	catalytic site [active]
743718002107	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
743718002108	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
743718002109	purine monophosphate binding site [chemical binding]; other site
743718002110	dimer interface [polypeptide binding]; other site
743718002111	putative catalytic residues [active]
743718002112	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
743718002113	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
743718002114	Septum formation; Region: Septum_form; pfam13845
743718002115	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
743718002116	amphipathic channel; other site
743718002117	Asn-Pro-Ala signature motifs; other site
743718002118	malate dehydrogenase; Provisional; Region: PRK05442
743718002119	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
743718002120	NAD(P) binding site [chemical binding]; other site
743718002121	dimer interface [polypeptide binding]; other site
743718002122	malate binding site [chemical binding]; other site
743718002123	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718002124	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
743718002125	Walker A/P-loop; other site
743718002126	ATP binding site [chemical binding]; other site
743718002127	Q-loop/lid; other site
743718002128	ABC transporter signature motif; other site
743718002129	Walker B; other site
743718002130	D-loop; other site
743718002131	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
743718002132	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
743718002133	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
743718002134	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
743718002135	active site
743718002136	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
743718002137	active site
743718002138	catalytic site [active]
743718002139	Aamy_C domain; Region: Aamy_C; smart00632
743718002140	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
743718002141	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
743718002142	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
743718002143	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
743718002144	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
743718002145	Ca binding site [ion binding]; other site
743718002146	active site
743718002147	catalytic site [active]
743718002148	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
743718002149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718002150	dimerization interface [polypeptide binding]; other site
743718002151	putative DNA binding site [nucleotide binding]; other site
743718002152	putative Zn2+ binding site [ion binding]; other site
743718002153	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
743718002154	hydrophobic ligand binding site; other site
743718002155	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
743718002156	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
743718002157	putative ligand binding site [chemical binding]; other site
743718002158	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
743718002159	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718002160	Walker A/P-loop; other site
743718002161	ATP binding site [chemical binding]; other site
743718002162	Q-loop/lid; other site
743718002163	ABC transporter signature motif; other site
743718002164	Walker B; other site
743718002165	D-loop; other site
743718002166	H-loop/switch region; other site
743718002167	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743718002168	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718002169	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718002170	TM-ABC transporter signature motif; other site
743718002171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718002172	putative DNA binding site [nucleotide binding]; other site
743718002173	putative Zn2+ binding site [ion binding]; other site
743718002174	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718002175	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743718002176	nucleotide binding site [chemical binding]; other site
743718002177	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743718002178	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718002179	Walker A/P-loop; other site
743718002180	ATP binding site [chemical binding]; other site
743718002181	Q-loop/lid; other site
743718002182	ABC transporter signature motif; other site
743718002183	Walker B; other site
743718002184	D-loop; other site
743718002185	H-loop/switch region; other site
743718002186	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
743718002187	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
743718002188	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
743718002189	putative active site [active]
743718002190	putative substrate binding site [chemical binding]; other site
743718002191	putative cosubstrate binding site; other site
743718002192	catalytic site [active]
743718002193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743718002194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718002195	Coenzyme A binding pocket [chemical binding]; other site
743718002196	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718002197	DNA binding site [nucleotide binding]
743718002198	lac repressor; Reviewed; Region: lacI; PRK09526
743718002199	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
743718002200	ligand binding site [chemical binding]; other site
743718002201	dimerization interface (open form) [polypeptide binding]; other site
743718002202	dimerization interface (closed form) [polypeptide binding]; other site
743718002203	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
743718002204	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
743718002205	putative N- and C-terminal domain interface [polypeptide binding]; other site
743718002206	putative active site [active]
743718002207	MgATP binding site [chemical binding]; other site
743718002208	catalytic site [active]
743718002209	metal binding site [ion binding]; metal-binding site
743718002210	putative carbohydrate binding site [chemical binding]; other site
743718002211	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
743718002212	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
743718002213	intersubunit interface [polypeptide binding]; other site
743718002214	active site
743718002215	Zn2+ binding site [ion binding]; other site
743718002216	L-arabinose isomerase; Provisional; Region: PRK02929
743718002217	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
743718002218	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743718002219	trimer interface [polypeptide binding]; other site
743718002220	substrate binding site [chemical binding]; other site
743718002221	Mn binding site [ion binding]; other site
743718002222	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
743718002223	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
743718002224	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743718002225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743718002226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718002227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002228	dimer interface [polypeptide binding]; other site
743718002229	conserved gate region; other site
743718002230	putative PBP binding loops; other site
743718002231	ABC-ATPase subunit interface; other site
743718002232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002233	putative PBP binding loops; other site
743718002234	ABC-ATPase subunit interface; other site
743718002235	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718002236	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718002237	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718002238	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718002239	DNA binding site [nucleotide binding]
743718002240	domain linker motif; other site
743718002241	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718002242	dimerization interface [polypeptide binding]; other site
743718002243	ligand binding site [chemical binding]; other site
743718002244	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
743718002245	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
743718002246	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743718002247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743718002248	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718002249	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718002250	DNA binding site [nucleotide binding]
743718002251	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718002252	dimerization interface [polypeptide binding]; other site
743718002253	ligand binding site [chemical binding]; other site
743718002254	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
743718002255	substrate binding site [chemical binding]; other site
743718002256	active site
743718002257	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718002258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002259	dimer interface [polypeptide binding]; other site
743718002260	conserved gate region; other site
743718002261	putative PBP binding loops; other site
743718002262	ABC-ATPase subunit interface; other site
743718002263	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718002264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718002265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002266	dimer interface [polypeptide binding]; other site
743718002267	putative PBP binding loops; other site
743718002268	ABC-ATPase subunit interface; other site
743718002269	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718002270	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718002271	alpha-galactosidase; Region: PLN02808; cl17638
743718002272	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
743718002273	substrate binding site [chemical binding]; other site
743718002274	active site
743718002275	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
743718002276	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
743718002277	dimer interface [polypeptide binding]; other site
743718002278	active site
743718002279	glycine-pyridoxal phosphate binding site [chemical binding]; other site
743718002280	folate binding site [chemical binding]; other site
743718002281	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
743718002282	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
743718002283	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
743718002284	homodimer interface [polypeptide binding]; other site
743718002285	NADP binding site [chemical binding]; other site
743718002286	substrate binding site [chemical binding]; other site
743718002287	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
743718002288	dimer interface [polypeptide binding]; other site
743718002289	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
743718002290	putative active site [active]
743718002291	putative catalytic site [active]
743718002292	putative DNA binding site [nucleotide binding]; other site
743718002293	putative phosphate binding site [ion binding]; other site
743718002294	metal binding site A [ion binding]; metal-binding site
743718002295	putative AP binding site [nucleotide binding]; other site
743718002296	putative metal binding site B [ion binding]; other site
743718002297	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
743718002298	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
743718002299	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
743718002300	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
743718002301	Domain of unknown function DUF59; Region: DUF59; cl00941
743718002302	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
743718002303	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743718002304	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
743718002305	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
743718002306	MgtE intracellular N domain; Region: MgtE_N; smart00924
743718002307	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
743718002308	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
743718002309	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
743718002310	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
743718002311	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
743718002312	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
743718002313	Family description; Region: UvrD_C_2; pfam13538
743718002314	AAA domain; Region: AAA_30; pfam13604
743718002315	Family description; Region: UvrD_C_2; pfam13538
743718002316	proline aminopeptidase P II; Provisional; Region: PRK10879
743718002317	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
743718002318	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
743718002319	active site
743718002320	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718002321	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
743718002322	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
743718002323	active site
743718002324	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
743718002325	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
743718002326	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
743718002327	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743718002328	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718002329	ATP binding site [chemical binding]; other site
743718002330	Mg++ binding site [ion binding]; other site
743718002331	motif III; other site
743718002332	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718002333	nucleotide binding region [chemical binding]; other site
743718002334	ATP-binding site [chemical binding]; other site
743718002335	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
743718002336	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
743718002337	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
743718002338	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
743718002339	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
743718002340	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
743718002341	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
743718002342	active site
743718002343	ATP binding site [chemical binding]; other site
743718002344	Phosphotransferase enzyme family; Region: APH; pfam01636
743718002345	substrate binding site [chemical binding]; other site
743718002346	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
743718002347	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
743718002348	putative NADH binding site [chemical binding]; other site
743718002349	putative active site [active]
743718002350	nudix motif; other site
743718002351	putative metal binding site [ion binding]; other site
743718002352	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
743718002353	catalytic residues [active]
743718002354	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
743718002355	Part of AAA domain; Region: AAA_19; pfam13245
743718002356	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
743718002357	Family description; Region: UvrD_C_2; pfam13538
743718002358	HRDC domain; Region: HRDC; pfam00570
743718002359	Transcription factor WhiB; Region: Whib; pfam02467
743718002360	Protein of unknown function DUF45; Region: DUF45; cl00636
743718002361	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
743718002362	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
743718002363	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
743718002364	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
743718002365	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
743718002366	Uncharacterized conserved protein [Function unknown]; Region: COG1615
743718002367	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743718002368	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718002369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002370	dimer interface [polypeptide binding]; other site
743718002371	ABC-ATPase subunit interface; other site
743718002372	putative PBP binding loops; other site
743718002373	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
743718002374	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
743718002375	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
743718002376	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
743718002377	substrate binding pocket [chemical binding]; other site
743718002378	membrane-bound complex binding site; other site
743718002379	hinge residues; other site
743718002380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002381	putative PBP binding loops; other site
743718002382	dimer interface [polypeptide binding]; other site
743718002383	ABC-ATPase subunit interface; other site
743718002384	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
743718002385	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002386	Walker A/P-loop; other site
743718002387	ATP binding site [chemical binding]; other site
743718002388	Q-loop/lid; other site
743718002389	ABC transporter signature motif; other site
743718002390	Walker B; other site
743718002391	D-loop; other site
743718002392	H-loop/switch region; other site
743718002393	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718002394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718002395	active site
743718002396	phosphorylation site [posttranslational modification]
743718002397	intermolecular recognition site; other site
743718002398	dimerization interface [polypeptide binding]; other site
743718002399	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718002400	DNA binding residues [nucleotide binding]
743718002401	dimerization interface [polypeptide binding]; other site
743718002402	Histidine kinase; Region: HisKA_3; pfam07730
743718002403	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743718002404	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
743718002405	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
743718002406	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
743718002407	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
743718002408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002409	ABC transporter signature motif; other site
743718002410	Walker B; other site
743718002411	D-loop; other site
743718002412	H-loop/switch region; other site
743718002413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718002414	Ligand Binding Site [chemical binding]; other site
743718002415	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
743718002416	Fe-S metabolism associated domain; Region: SufE; cl00951
743718002417	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
743718002418	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
743718002419	active site residue [active]
743718002420	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
743718002421	active site residue [active]
743718002422	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
743718002423	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
743718002424	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
743718002425	NAD(P) binding site [chemical binding]; other site
743718002426	catalytic residues [active]
743718002427	Protein of unknown function (DUF779); Region: DUF779; pfam05610
743718002428	DoxX-like family; Region: DoxX_2; pfam13564
743718002429	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
743718002430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718002431	active site
743718002432	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
743718002433	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718002434	nucleotide binding region [chemical binding]; other site
743718002435	ATP-binding site [chemical binding]; other site
743718002436	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743718002437	ligand binding site [chemical binding]; other site
743718002438	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
743718002439	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
743718002440	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
743718002441	HsdM N-terminal domain; Region: HsdM_N; pfam12161
743718002442	Methyltransferase domain; Region: Methyltransf_26; pfam13659
743718002443	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
743718002444	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
743718002445	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
743718002446	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743718002447	active site
743718002448	catalytic site [active]
743718002449	substrate binding site [chemical binding]; other site
743718002450	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
743718002451	Dimer interface [polypeptide binding]; other site
743718002452	Lsr2; Region: Lsr2; pfam11774
743718002453	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
743718002454	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
743718002455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718002456	ATP binding site [chemical binding]; other site
743718002457	putative Mg++ binding site [ion binding]; other site
743718002458	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
743718002459	Fic family protein [Function unknown]; Region: COG3177
743718002460	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
743718002461	Fic/DOC family; Region: Fic; pfam02661
743718002462	HTH DNA binding domain; Region: HTH_13; pfam11972
743718002463	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743718002464	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
743718002465	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
743718002466	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
743718002467	homodimer interface [polypeptide binding]; other site
743718002468	active site
743718002469	TDP-binding site; other site
743718002470	acceptor substrate-binding pocket; other site
743718002471	malate synthase A; Region: malate_syn_A; TIGR01344
743718002472	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
743718002473	active site
743718002474	isocitrate lyase; Provisional; Region: PRK15063
743718002475	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
743718002476	tetramer interface [polypeptide binding]; other site
743718002477	active site
743718002478	Mg2+/Mn2+ binding site [ion binding]; other site
743718002479	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743718002480	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718002481	non-specific DNA binding site [nucleotide binding]; other site
743718002482	salt bridge; other site
743718002483	sequence-specific DNA binding site [nucleotide binding]; other site
743718002484	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
743718002485	Domain of unknown function (DUF955); Region: DUF955; pfam06114
743718002486	putative acyltransferase; Provisional; Region: PRK05790
743718002487	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
743718002488	dimer interface [polypeptide binding]; other site
743718002489	active site
743718002490	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
743718002491	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
743718002492	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
743718002493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718002494	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
743718002495	NAD(P) binding site [chemical binding]; other site
743718002496	active site
743718002497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718002498	metabolite-proton symporter; Region: 2A0106; TIGR00883
743718002499	putative substrate translocation pore; other site
743718002500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718002501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718002502	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718002503	dimerization interface [polypeptide binding]; other site
743718002504	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
743718002505	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
743718002506	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
743718002507	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
743718002508	putative active site [active]
743718002509	PhoH-like protein; Region: PhoH; pfam02562
743718002510	fumarate hydratase; Reviewed; Region: fumC; PRK00485
743718002511	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
743718002512	active sites [active]
743718002513	tetramer interface [polypeptide binding]; other site
743718002514	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
743718002515	active site clefts [active]
743718002516	zinc binding site [ion binding]; other site
743718002517	dimer interface [polypeptide binding]; other site
743718002518	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718002519	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
743718002520	putative substrate binding site [chemical binding]; other site
743718002521	putative ATP binding site [chemical binding]; other site
743718002522	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
743718002523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002524	Walker A/P-loop; other site
743718002525	ATP binding site [chemical binding]; other site
743718002526	ABC transporter; Region: ABC_tran; pfam00005
743718002527	Q-loop/lid; other site
743718002528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002529	ABC transporter signature motif; other site
743718002530	Walker B; other site
743718002531	D-loop; other site
743718002532	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
743718002533	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
743718002534	generic binding surface II; other site
743718002535	generic binding surface I; other site
743718002536	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
743718002537	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
743718002538	RmuC family; Region: RmuC; pfam02646
743718002539	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
743718002540	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718002541	Walker A/P-loop; other site
743718002542	ATP binding site [chemical binding]; other site
743718002543	Q-loop/lid; other site
743718002544	ABC transporter signature motif; other site
743718002545	Walker B; other site
743718002546	D-loop; other site
743718002547	H-loop/switch region; other site
743718002548	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
743718002549	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
743718002550	DinB superfamily; Region: DinB_2; pfam12867
743718002551	GTP-binding protein YchF; Reviewed; Region: PRK09601
743718002552	YchF GTPase; Region: YchF; cd01900
743718002553	G1 box; other site
743718002554	GTP/Mg2+ binding site [chemical binding]; other site
743718002555	Switch I region; other site
743718002556	G2 box; other site
743718002557	Switch II region; other site
743718002558	G3 box; other site
743718002559	G4 box; other site
743718002560	G5 box; other site
743718002561	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
743718002562	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743718002563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718002564	Coenzyme A binding pocket [chemical binding]; other site
743718002565	Methyltransferase domain; Region: Methyltransf_23; pfam13489
743718002566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718002567	S-adenosylmethionine binding site [chemical binding]; other site
743718002568	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
743718002569	active site
743718002570	NTP binding site [chemical binding]; other site
743718002571	metal binding triad [ion binding]; metal-binding site
743718002572	antibiotic binding site [chemical binding]; other site
743718002573	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
743718002574	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
743718002575	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
743718002576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718002577	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
743718002578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002579	putative PBP binding loops; other site
743718002580	dimer interface [polypeptide binding]; other site
743718002581	ABC-ATPase subunit interface; other site
743718002582	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
743718002583	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
743718002584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002585	dimer interface [polypeptide binding]; other site
743718002586	conserved gate region; other site
743718002587	putative PBP binding loops; other site
743718002588	ABC-ATPase subunit interface; other site
743718002589	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
743718002590	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718002591	Walker A/P-loop; other site
743718002592	ATP binding site [chemical binding]; other site
743718002593	Q-loop/lid; other site
743718002594	ABC transporter signature motif; other site
743718002595	Walker B; other site
743718002596	D-loop; other site
743718002597	H-loop/switch region; other site
743718002598	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718002599	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718002600	Walker A/P-loop; other site
743718002601	ATP binding site [chemical binding]; other site
743718002602	Q-loop/lid; other site
743718002603	ABC transporter signature motif; other site
743718002604	Walker B; other site
743718002605	D-loop; other site
743718002606	H-loop/switch region; other site
743718002607	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718002608	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743718002609	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743718002610	Walker A/P-loop; other site
743718002611	ATP binding site [chemical binding]; other site
743718002612	Q-loop/lid; other site
743718002613	ABC transporter signature motif; other site
743718002614	Walker B; other site
743718002615	D-loop; other site
743718002616	H-loop/switch region; other site
743718002617	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743718002618	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743718002619	Walker A/P-loop; other site
743718002620	ATP binding site [chemical binding]; other site
743718002621	Q-loop/lid; other site
743718002622	ABC transporter signature motif; other site
743718002623	Walker B; other site
743718002624	D-loop; other site
743718002625	H-loop/switch region; other site
743718002626	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
743718002627	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
743718002628	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
743718002629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002630	dimer interface [polypeptide binding]; other site
743718002631	conserved gate region; other site
743718002632	putative PBP binding loops; other site
743718002633	ABC-ATPase subunit interface; other site
743718002634	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
743718002635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718002636	dimer interface [polypeptide binding]; other site
743718002637	conserved gate region; other site
743718002638	putative PBP binding loops; other site
743718002639	ABC-ATPase subunit interface; other site
743718002640	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
743718002641	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718002642	Walker A/P-loop; other site
743718002643	ATP binding site [chemical binding]; other site
743718002644	Q-loop/lid; other site
743718002645	ABC transporter signature motif; other site
743718002646	Walker B; other site
743718002647	D-loop; other site
743718002648	H-loop/switch region; other site
743718002649	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718002650	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718002651	Walker A/P-loop; other site
743718002652	ATP binding site [chemical binding]; other site
743718002653	Q-loop/lid; other site
743718002654	ABC transporter signature motif; other site
743718002655	Walker B; other site
743718002656	D-loop; other site
743718002657	H-loop/switch region; other site
743718002658	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718002659	BCCT family transporter; Region: BCCT; pfam02028
743718002660	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
743718002661	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
743718002662	G1 box; other site
743718002663	putative GEF interaction site [polypeptide binding]; other site
743718002664	GTP/Mg2+ binding site [chemical binding]; other site
743718002665	Switch I region; other site
743718002666	G2 box; other site
743718002667	G3 box; other site
743718002668	Switch II region; other site
743718002669	G4 box; other site
743718002670	G5 box; other site
743718002671	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
743718002672	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
743718002673	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
743718002674	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
743718002675	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
743718002676	VanW like protein; Region: VanW; pfam04294
743718002677	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
743718002678	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
743718002679	Prephenate dehydratase; Region: PDT; pfam00800
743718002680	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
743718002681	putative L-Phe binding site [chemical binding]; other site
743718002682	prephenate dehydrogenase; Validated; Region: PRK08507
743718002683	Ferredoxin [Energy production and conversion]; Region: COG1146
743718002684	4Fe-4S binding domain; Region: Fer4; pfam00037
743718002685	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
743718002686	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718002687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718002688	homodimer interface [polypeptide binding]; other site
743718002689	catalytic residue [active]
743718002690	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
743718002691	dimer interface [polypeptide binding]; other site
743718002692	Citrate synthase; Region: Citrate_synt; pfam00285
743718002693	active site
743718002694	citrylCoA binding site [chemical binding]; other site
743718002695	NADH binding [chemical binding]; other site
743718002696	cationic pore residues; other site
743718002697	oxalacetate/citrate binding site [chemical binding]; other site
743718002698	coenzyme A binding site [chemical binding]; other site
743718002699	catalytic triad [active]
743718002700	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
743718002701	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
743718002702	putative trimer interface [polypeptide binding]; other site
743718002703	putative CoA binding site [chemical binding]; other site
743718002704	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
743718002705	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
743718002706	metal binding site [ion binding]; metal-binding site
743718002707	putative dimer interface [polypeptide binding]; other site
743718002708	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
743718002709	dihydropteroate synthase; Region: DHPS; TIGR01496
743718002710	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
743718002711	substrate binding pocket [chemical binding]; other site
743718002712	dimer interface [polypeptide binding]; other site
743718002713	inhibitor binding site; inhibition site
743718002714	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
743718002715	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
743718002716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743718002717	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
743718002718	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718002719	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718002720	DNA binding residues [nucleotide binding]
743718002721	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743718002722	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
743718002723	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
743718002724	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
743718002725	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
743718002726	active site
743718002727	HIGH motif; other site
743718002728	dimer interface [polypeptide binding]; other site
743718002729	KMSKS motif; other site
743718002730	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718002731	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
743718002732	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
743718002733	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
743718002734	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
743718002735	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743718002736	catalytic loop [active]
743718002737	iron binding site [ion binding]; other site
743718002738	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
743718002739	L-aspartate oxidase; Provisional; Region: PRK06175
743718002740	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
743718002741	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
743718002742	putative Iron-sulfur protein interface [polypeptide binding]; other site
743718002743	putative proximal heme binding site [chemical binding]; other site
743718002744	putative SdhC-like subunit interface [polypeptide binding]; other site
743718002745	putative distal heme binding site [chemical binding]; other site
743718002746	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
743718002747	putative Iron-sulfur protein interface [polypeptide binding]; other site
743718002748	putative proximal heme binding site [chemical binding]; other site
743718002749	putative SdhD-like interface [polypeptide binding]; other site
743718002750	putative distal heme binding site [chemical binding]; other site
743718002751	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718002752	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
743718002753	active site
743718002754	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
743718002755	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
743718002756	metal binding site [ion binding]; metal-binding site
743718002757	putative dimer interface [polypeptide binding]; other site
743718002758	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
743718002759	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
743718002760	ligand binding site [chemical binding]; other site
743718002761	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
743718002762	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718002763	Walker A/P-loop; other site
743718002764	ATP binding site [chemical binding]; other site
743718002765	Q-loop/lid; other site
743718002766	ABC transporter signature motif; other site
743718002767	Walker B; other site
743718002768	D-loop; other site
743718002769	H-loop/switch region; other site
743718002770	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743718002771	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718002772	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
743718002773	TM-ABC transporter signature motif; other site
743718002774	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
743718002775	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718002776	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
743718002777	TM-ABC transporter signature motif; other site
743718002778	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
743718002779	active site
743718002780	catalytic motif [active]
743718002781	Zn binding site [ion binding]; other site
743718002782	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
743718002783	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
743718002784	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
743718002785	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
743718002786	adenosine deaminase; Provisional; Region: PRK09358
743718002787	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
743718002788	active site
743718002789	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
743718002790	intersubunit interface [polypeptide binding]; other site
743718002791	active site
743718002792	catalytic residue [active]
743718002793	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
743718002794	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
743718002795	FAD binding pocket [chemical binding]; other site
743718002796	FAD binding motif [chemical binding]; other site
743718002797	phosphate binding motif [ion binding]; other site
743718002798	NAD binding pocket [chemical binding]; other site
743718002799	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
743718002800	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
743718002801	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
743718002802	active site
743718002803	substrate binding site [chemical binding]; other site
743718002804	metal binding site [ion binding]; metal-binding site
743718002805	purine nucleoside phosphorylase; Provisional; Region: PRK08202
743718002806	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
743718002807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718002808	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
743718002809	NUDIX domain; Region: NUDIX; pfam00293
743718002810	nudix motif; other site
743718002811	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
743718002812	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743718002813	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
743718002814	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
743718002815	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
743718002816	carboxyltransferase (CT) interaction site; other site
743718002817	biotinylation site [posttranslational modification]; other site
743718002818	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
743718002819	active site
743718002820	dimer interface [polypeptide binding]; other site
743718002821	Membrane transport protein; Region: Mem_trans; cl09117
743718002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
743718002823	Domain of unknown function (DUF202); Region: DUF202; cl09954
743718002824	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
743718002825	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
743718002826	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
743718002827	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
743718002828	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
743718002829	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
743718002830	cyclase homology domain; Region: CHD; cd07302
743718002831	nucleotidyl binding site; other site
743718002832	metal binding site [ion binding]; metal-binding site
743718002833	dimer interface [polypeptide binding]; other site
743718002834	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
743718002835	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
743718002836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718002837	putative substrate translocation pore; other site
743718002838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
743718002839	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
743718002840	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743718002841	putative active site [active]
743718002842	catalytic site [active]
743718002843	putative metal binding site [ion binding]; other site
743718002844	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
743718002845	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
743718002846	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
743718002847	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718002848	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718002849	dimerization interface [polypeptide binding]; other site
743718002850	Lysine efflux permease [General function prediction only]; Region: COG1279
743718002851	aminotransferase; Validated; Region: PRK07777
743718002852	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718002853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718002854	homodimer interface [polypeptide binding]; other site
743718002855	catalytic residue [active]
743718002856	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
743718002857	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
743718002858	ATP binding site [chemical binding]; other site
743718002859	Walker A motif; other site
743718002860	hexamer interface [polypeptide binding]; other site
743718002861	Walker B motif; other site
743718002862	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
743718002863	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743718002864	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
743718002865	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
743718002866	peptide chain release factor 2; Validated; Region: prfB; PRK00578
743718002867	This domain is found in peptide chain release factors; Region: PCRF; smart00937
743718002868	RF-1 domain; Region: RF-1; pfam00472
743718002869	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
743718002870	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002871	Walker A/P-loop; other site
743718002872	ATP binding site [chemical binding]; other site
743718002873	Q-loop/lid; other site
743718002874	ABC transporter signature motif; other site
743718002875	Walker B; other site
743718002876	D-loop; other site
743718002877	H-loop/switch region; other site
743718002878	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
743718002879	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
743718002880	Peptidase family M23; Region: Peptidase_M23; pfam01551
743718002881	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
743718002882	SmpB-tmRNA interface; other site
743718002883	OsmC-like protein; Region: OsmC; pfam02566
743718002884	EamA-like transporter family; Region: EamA; pfam00892
743718002885	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
743718002886	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718002887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718002888	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
743718002889	putative dimerization interface [polypeptide binding]; other site
743718002890	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743718002891	active site
743718002892	Zn binding site [ion binding]; other site
743718002893	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
743718002894	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
743718002895	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743718002896	catalytic residue [active]
743718002897	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
743718002898	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718002899	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743718002900	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718002901	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
743718002902	active site
743718002903	trimer interface [polypeptide binding]; other site
743718002904	allosteric site; other site
743718002905	active site lid [active]
743718002906	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743718002907	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
743718002908	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
743718002909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718002910	ATP binding site [chemical binding]; other site
743718002911	putative Mg++ binding site [ion binding]; other site
743718002912	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
743718002913	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
743718002914	active site
743718002915	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
743718002916	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
743718002917	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
743718002918	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743718002919	catalytic Zn binding site [ion binding]; other site
743718002920	NAD(P) binding site [chemical binding]; other site
743718002921	structural Zn binding site [ion binding]; other site
743718002922	glutamate racemase; Provisional; Region: PRK00865
743718002923	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
743718002924	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
743718002925	active site
743718002926	dimerization interface [polypeptide binding]; other site
743718002927	ribonuclease PH; Reviewed; Region: rph; PRK00173
743718002928	Ribonuclease PH; Region: RNase_PH_bact; cd11362
743718002929	hexamer interface [polypeptide binding]; other site
743718002930	active site
743718002931	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743718002932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718002933	active site
743718002934	phosphorylation site [posttranslational modification]
743718002935	intermolecular recognition site; other site
743718002936	dimerization interface [polypeptide binding]; other site
743718002937	LytTr DNA-binding domain; Region: LytTR; smart00850
743718002938	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
743718002939	Histidine kinase; Region: His_kinase; pfam06580
743718002940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718002941	ATP binding site [chemical binding]; other site
743718002942	Mg2+ binding site [ion binding]; other site
743718002943	G-X-G motif; other site
743718002944	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
743718002945	Na binding site [ion binding]; other site
743718002946	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
743718002947	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
743718002948	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
743718002949	Na binding site [ion binding]; other site
743718002950	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743718002951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002952	Walker A/P-loop; other site
743718002953	ATP binding site [chemical binding]; other site
743718002954	Q-loop/lid; other site
743718002955	ABC transporter signature motif; other site
743718002956	Walker B; other site
743718002957	D-loop; other site
743718002958	H-loop/switch region; other site
743718002959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718002961	Walker A/P-loop; other site
743718002962	Walker A/P-loop; other site
743718002963	ATP binding site [chemical binding]; other site
743718002964	ATP binding site [chemical binding]; other site
743718002965	Q-loop/lid; other site
743718002966	ABC transporter signature motif; other site
743718002967	Walker B; other site
743718002968	D-loop; other site
743718002969	H-loop/switch region; other site
743718002970	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743718002971	nudix motif; other site
743718002972	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743718002973	catalytic residues [active]
743718002974	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
743718002975	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
743718002976	catalytic triad [active]
743718002977	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
743718002978	oligomerisation interface [polypeptide binding]; other site
743718002979	mobile loop; other site
743718002980	roof hairpin; other site
743718002981	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743718002982	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743718002983	active site
743718002984	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
743718002985	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
743718002986	catalytic site [active]
743718002987	putative active site [active]
743718002988	putative substrate binding site [chemical binding]; other site
743718002989	dimer interface [polypeptide binding]; other site
743718002990	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
743718002991	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
743718002992	G2 box; other site
743718002993	Switch I region; other site
743718002994	G3 box; other site
743718002995	Switch II region; other site
743718002996	Dynamin family; Region: Dynamin_N; pfam00350
743718002997	YfjP GTPase; Region: YfjP; cd11383
743718002998	G1 box; other site
743718002999	GTP/Mg2+ binding site [chemical binding]; other site
743718003000	Switch I region; other site
743718003001	G2 box; other site
743718003002	Switch II region; other site
743718003003	G3 box; other site
743718003004	G4 box; other site
743718003005	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
743718003006	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
743718003007	dimer interface [polypeptide binding]; other site
743718003008	ssDNA binding site [nucleotide binding]; other site
743718003009	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743718003010	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
743718003011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718003012	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718003013	ABC transporter; Region: ABC_tran_2; pfam12848
743718003014	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718003015	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
743718003016	G1 box; other site
743718003017	GTP/Mg2+ binding site [chemical binding]; other site
743718003018	G2 box; other site
743718003019	Switch I region; other site
743718003020	G3 box; other site
743718003021	Switch II region; other site
743718003022	YfjP GTPase; Region: YfjP; cd11383
743718003023	G1 box; other site
743718003024	GTP/Mg2+ binding site [chemical binding]; other site
743718003025	Switch I region; other site
743718003026	G2 box; other site
743718003027	Switch II region; other site
743718003028	G3 box; other site
743718003029	G4 box; other site
743718003030	G5 box; other site
743718003031	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743718003032	active site
743718003033	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
743718003034	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
743718003035	active site
743718003036	DNA binding site [nucleotide binding]
743718003037	Int/Topo IB signature motif; other site
743718003038	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
743718003039	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
743718003040	active site
743718003041	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
743718003042	catalytic triad [active]
743718003043	dimer interface [polypeptide binding]; other site
743718003044	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
743718003045	apolar tunnel; other site
743718003046	heme binding site [chemical binding]; other site
743718003047	dimerization interface [polypeptide binding]; other site
743718003048	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
743718003049	active site turn [active]
743718003050	phosphorylation site [posttranslational modification]
743718003051	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743718003052	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743718003053	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
743718003054	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
743718003055	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
743718003056	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
743718003057	Zn binding site [ion binding]; other site
743718003058	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
743718003059	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
743718003060	active site
743718003061	Zn binding site [ion binding]; other site
743718003062	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
743718003063	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
743718003064	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
743718003065	putative DNA binding site [nucleotide binding]; other site
743718003066	catalytic residue [active]
743718003067	putative H2TH interface [polypeptide binding]; other site
743718003068	putative catalytic residues [active]
743718003069	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
743718003070	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
743718003071	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743718003072	active site
743718003073	DNA binding site [nucleotide binding]
743718003074	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718003075	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
743718003076	Protein of unknown function (DUF419); Region: DUF419; cl15265
743718003077	CAAX protease self-immunity; Region: Abi; pfam02517
743718003078	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
743718003079	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718003080	DNA-binding site [nucleotide binding]; DNA binding site
743718003081	serine O-acetyltransferase; Region: cysE; TIGR01172
743718003082	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
743718003083	trimer interface [polypeptide binding]; other site
743718003084	active site
743718003085	substrate binding site [chemical binding]; other site
743718003086	CoA binding site [chemical binding]; other site
743718003087	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
743718003088	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
743718003089	dimer interface [polypeptide binding]; other site
743718003090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718003091	catalytic residue [active]
743718003092	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
743718003093	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718003094	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
743718003095	Predicted transcriptional regulators [Transcription]; Region: COG1695
743718003096	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
743718003097	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
743718003098	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718003099	putative metal binding site [ion binding]; other site
743718003100	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
743718003101	active site
743718003102	trigger factor; Provisional; Region: tig; PRK01490
743718003103	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743718003104	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
743718003105	Clp protease; Region: CLP_protease; pfam00574
743718003106	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743718003107	oligomer interface [polypeptide binding]; other site
743718003108	active site residues [active]
743718003109	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
743718003110	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743718003111	oligomer interface [polypeptide binding]; other site
743718003112	active site residues [active]
743718003113	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
743718003114	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
743718003115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718003116	Walker A motif; other site
743718003117	ATP binding site [chemical binding]; other site
743718003118	Walker B motif; other site
743718003119	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
743718003120	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
743718003121	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
743718003122	acyl-activating enzyme (AAE) consensus motif; other site
743718003123	putative AMP binding site [chemical binding]; other site
743718003124	putative active site [active]
743718003125	putative CoA binding site [chemical binding]; other site
743718003126	chorismate mutase; Provisional; Region: PRK09239
743718003127	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
743718003128	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718003129	active site
743718003130	HIGH motif; other site
743718003131	nucleotide binding site [chemical binding]; other site
743718003132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718003133	active site
743718003134	KMSKS motif; other site
743718003135	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
743718003136	tRNA binding surface [nucleotide binding]; other site
743718003137	anticodon binding site; other site
743718003138	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
743718003139	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
743718003140	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
743718003141	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718003142	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
743718003143	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
743718003144	putative deacylase active site [active]
743718003145	CHRD domain; Region: CHRD; pfam07452
743718003146	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
743718003147	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
743718003148	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718003149	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718003150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718003151	active site
743718003152	phosphorylation site [posttranslational modification]
743718003153	intermolecular recognition site; other site
743718003154	dimerization interface [polypeptide binding]; other site
743718003155	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718003156	DNA binding residues [nucleotide binding]
743718003157	dimerization interface [polypeptide binding]; other site
743718003158	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
743718003159	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
743718003160	NAD(P) binding site [chemical binding]; other site
743718003161	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
743718003162	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
743718003163	oligomer interface [polypeptide binding]; other site
743718003164	metal binding site [ion binding]; metal-binding site
743718003165	metal binding site [ion binding]; metal-binding site
743718003166	putative Cl binding site [ion binding]; other site
743718003167	basic sphincter; other site
743718003168	hydrophobic gate; other site
743718003169	periplasmic entrance; other site
743718003170	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
743718003171	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
743718003172	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
743718003173	putative active site [active]
743718003174	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
743718003175	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
743718003176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
743718003177	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
743718003178	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
743718003179	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
743718003180	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
743718003181	TIGR02569 family protein; Region: TIGR02569_actnb
743718003182	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
743718003183	Amidinotransferase; Region: Amidinotransf; cl12043
743718003184	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
743718003185	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
743718003186	putative active site [active]
743718003187	putative metal binding site [ion binding]; other site
743718003188	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743718003189	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718003190	salt bridge; other site
743718003191	non-specific DNA binding site [nucleotide binding]; other site
743718003192	sequence-specific DNA binding site [nucleotide binding]; other site
743718003193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743718003194	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743718003195	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
743718003196	substrate binding site [chemical binding]; other site
743718003197	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743718003198	active site
743718003199	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743718003200	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
743718003201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718003202	Walker A motif; other site
743718003203	ATP binding site [chemical binding]; other site
743718003204	Walker B motif; other site
743718003205	arginine finger; other site
743718003206	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
743718003207	Part of AAA domain; Region: AAA_19; pfam13245
743718003208	Family description; Region: UvrD_C_2; pfam13538
743718003209	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
743718003210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718003211	ATP binding site [chemical binding]; other site
743718003212	putative Mg++ binding site [ion binding]; other site
743718003213	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718003214	nucleotide binding region [chemical binding]; other site
743718003215	ATP-binding site [chemical binding]; other site
743718003216	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
743718003217	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718003218	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718003219	ATP binding site [chemical binding]; other site
743718003220	putative Mg++ binding site [ion binding]; other site
743718003221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718003222	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
743718003223	nucleotide binding region [chemical binding]; other site
743718003224	ATP-binding site [chemical binding]; other site
743718003225	Protein of unknown function (DUF419); Region: DUF419; cl15265
743718003226	Trehalose utilisation; Region: ThuA; pfam06283
743718003227	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718003228	FOG: PKD repeat [General function prediction only]; Region: COG3291
743718003229	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718003230	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
743718003231	metal binding site [ion binding]; metal-binding site
743718003232	ligand binding site [chemical binding]; other site
743718003233	FOG: PKD repeat [General function prediction only]; Region: COG3291
743718003234	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718003235	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
743718003236	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743718003237	Protein of unknown function (DUF419); Region: DUF419; cl15265
743718003238	Protein of unknown function DUF86; Region: DUF86; pfam01934
743718003239	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718003240	dimerization interface [polypeptide binding]; other site
743718003241	putative DNA binding site [nucleotide binding]; other site
743718003242	putative Zn2+ binding site [ion binding]; other site
743718003243	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
743718003244	active site
743718003245	NTP binding site [chemical binding]; other site
743718003246	metal binding triad [ion binding]; metal-binding site
743718003247	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
743718003248	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718003249	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718003250	DNA binding site [nucleotide binding]
743718003251	domain linker motif; other site
743718003252	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718003253	Right handed beta helix region; Region: Beta_helix; pfam13229
743718003254	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
743718003255	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
743718003256	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
743718003257	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
743718003258	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
743718003259	putative dimer interface [polypeptide binding]; other site
743718003260	N-terminal domain interface [polypeptide binding]; other site
743718003261	putative substrate binding pocket (H-site) [chemical binding]; other site
743718003262	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
743718003263	Domain of unknown function (DUF385); Region: DUF385; cl04387
743718003264	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743718003265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718003266	non-specific DNA binding site [nucleotide binding]; other site
743718003267	salt bridge; other site
743718003268	sequence-specific DNA binding site [nucleotide binding]; other site
743718003269	proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873
743718003270	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
743718003271	Walker A/P-loop; other site
743718003272	ATP binding site [chemical binding]; other site
743718003273	Q-loop/lid; other site
743718003274	ABC transporter signature motif; other site
743718003275	Walker B; other site
743718003276	D-loop; other site
743718003277	H-loop/switch region; other site
743718003278	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
743718003279	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
743718003280	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
743718003281	putative PBP binding regions; other site
743718003282	ABC-ATPase subunit  interface; other site
743718003283	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743718003284	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
743718003285	intersubunit interface [polypeptide binding]; other site
743718003286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718003287	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
743718003288	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
743718003289	Moco binding site; other site
743718003290	metal coordination site [ion binding]; other site
743718003291	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
743718003292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718003293	NAD(P) binding site [chemical binding]; other site
743718003294	active site
743718003295	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
743718003296	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
743718003297	HIGH motif; other site
743718003298	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
743718003299	active site
743718003300	KMSKS motif; other site
743718003301	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
743718003302	tRNA binding surface [nucleotide binding]; other site
743718003303	anticodon binding site; other site
743718003304	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
743718003305	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743718003306	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743718003307	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
743718003308	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
743718003309	DAK2 domain; Region: Dak2; cl03685
743718003310	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
743718003311	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
743718003312	dimerization domain swap beta strand [polypeptide binding]; other site
743718003313	regulatory protein interface [polypeptide binding]; other site
743718003314	active site
743718003315	regulatory phosphorylation site [posttranslational modification]; other site
743718003316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718003317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718003318	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743718003319	putative substrate translocation pore; other site
743718003320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718003321	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
743718003322	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
743718003323	active site
743718003324	multimer interface [polypeptide binding]; other site
743718003325	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
743718003326	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
743718003327	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743718003328	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
743718003329	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
743718003330	Nitrogen regulatory protein P-II; Region: P-II; smart00938
743718003331	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
743718003332	metal binding triad; other site
743718003333	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
743718003334	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743718003335	Zn2+ binding site [ion binding]; other site
743718003336	Mg2+ binding site [ion binding]; other site
743718003337	signal recognition particle protein; Provisional; Region: PRK10867
743718003338	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
743718003339	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
743718003340	P loop; other site
743718003341	GTP binding site [chemical binding]; other site
743718003342	Signal peptide binding domain; Region: SRP_SPB; pfam02978
743718003343	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743718003344	Amidohydrolase; Region: Amidohydro_4; pfam13147
743718003345	active site
743718003346	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
743718003347	hypothetical protein; Provisional; Region: PRK02821
743718003348	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
743718003349	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
743718003350	RimM N-terminal domain; Region: RimM; pfam01782
743718003351	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
743718003352	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
743718003353	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
743718003354	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
743718003355	Catalytic site [active]
743718003356	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
743718003357	RNA/DNA hybrid binding site [nucleotide binding]; other site
743718003358	active site
743718003359	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
743718003360	hypothetical protein; Reviewed; Region: PRK12497
743718003361	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
743718003362	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
743718003363	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
743718003364	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
743718003365	DNA protecting protein DprA; Region: dprA; TIGR00732
743718003366	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
743718003367	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
743718003368	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743718003369	active site
743718003370	DNA binding site [nucleotide binding]
743718003371	Int/Topo IB signature motif; other site
743718003372	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
743718003373	rRNA interaction site [nucleotide binding]; other site
743718003374	S8 interaction site; other site
743718003375	putative laminin-1 binding site; other site
743718003376	elongation factor Ts; Provisional; Region: tsf; PRK09377
743718003377	UBA/TS-N domain; Region: UBA; pfam00627
743718003378	Elongation factor TS; Region: EF_TS; pfam00889
743718003379	Elongation factor TS; Region: EF_TS; pfam00889
743718003380	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
743718003381	putative nucleotide binding site [chemical binding]; other site
743718003382	uridine monophosphate binding site [chemical binding]; other site
743718003383	homohexameric interface [polypeptide binding]; other site
743718003384	ribosome recycling factor; Reviewed; Region: frr; PRK00083
743718003385	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
743718003386	hinge region; other site
743718003387	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
743718003388	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
743718003389	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
743718003390	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743718003391	FeS/SAM binding site; other site
743718003392	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
743718003393	DivIVA domain; Region: DivI1A_domain; TIGR03544
743718003394	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
743718003395	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743718003396	DNA binding residues [nucleotide binding]
743718003397	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
743718003398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718003399	putative substrate translocation pore; other site
743718003400	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
743718003401	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
743718003402	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
743718003403	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
743718003404	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
743718003405	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
743718003406	active site
743718003407	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
743718003408	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
743718003409	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
743718003410	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
743718003411	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
743718003412	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718003413	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
743718003414	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
743718003415	putative DNA binding site [nucleotide binding]; other site
743718003416	catalytic residue [active]
743718003417	putative H2TH interface [polypeptide binding]; other site
743718003418	putative catalytic residues [active]
743718003419	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
743718003420	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
743718003421	prolyl-tRNA synthetase; Provisional; Region: PRK09194
743718003422	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
743718003423	dimer interface [polypeptide binding]; other site
743718003424	motif 1; other site
743718003425	active site
743718003426	motif 2; other site
743718003427	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
743718003428	putative deacylase active site [active]
743718003429	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
743718003430	active site
743718003431	motif 3; other site
743718003432	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
743718003433	anticodon binding site; other site
743718003434	Sm and related proteins; Region: Sm_like; cl00259
743718003435	heptamer interface [polypeptide binding]; other site
743718003436	Sm1 motif; other site
743718003437	hexamer interface [polypeptide binding]; other site
743718003438	RNA binding site [nucleotide binding]; other site
743718003439	Sm2 motif; other site
743718003440	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
743718003441	NusA N-terminal domain; Region: NusA_N; pfam08529
743718003442	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
743718003443	RNA binding site [nucleotide binding]; other site
743718003444	homodimer interface [polypeptide binding]; other site
743718003445	NusA-like KH domain; Region: KH_5; pfam13184
743718003446	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
743718003447	G-X-X-G motif; other site
743718003448	Protein of unknown function (DUF448); Region: DUF448; pfam04296
743718003449	putative RNA binding cleft [nucleotide binding]; other site
743718003450	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
743718003451	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
743718003452	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
743718003453	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
743718003454	G1 box; other site
743718003455	putative GEF interaction site [polypeptide binding]; other site
743718003456	GTP/Mg2+ binding site [chemical binding]; other site
743718003457	Switch I region; other site
743718003458	G2 box; other site
743718003459	G3 box; other site
743718003460	Switch II region; other site
743718003461	G4 box; other site
743718003462	G5 box; other site
743718003463	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
743718003464	Translation-initiation factor 2; Region: IF-2; pfam11987
743718003465	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
743718003466	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
743718003467	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
743718003468	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
743718003469	RNA binding site [nucleotide binding]; other site
743718003470	active site
743718003471	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
743718003472	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
743718003473	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
743718003474	active site
743718003475	Riboflavin kinase; Region: Flavokinase; pfam01687
743718003476	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
743718003477	16S/18S rRNA binding site [nucleotide binding]; other site
743718003478	S13e-L30e interaction site [polypeptide binding]; other site
743718003479	25S rRNA binding site [nucleotide binding]; other site
743718003480	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
743718003481	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
743718003482	oligomer interface [polypeptide binding]; other site
743718003483	RNA binding site [nucleotide binding]; other site
743718003484	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
743718003485	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
743718003486	RNase E interface [polypeptide binding]; other site
743718003487	trimer interface [polypeptide binding]; other site
743718003488	active site
743718003489	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
743718003490	putative nucleic acid binding region [nucleotide binding]; other site
743718003491	G-X-X-G motif; other site
743718003492	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
743718003493	RNA binding site [nucleotide binding]; other site
743718003494	domain interface; other site
743718003495	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743718003496	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743718003497	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743718003498	dihydrodipicolinate reductase; Provisional; Region: PRK00048
743718003499	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
743718003500	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
743718003501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718003502	Coenzyme A binding pocket [chemical binding]; other site
743718003503	AzlC protein; Region: AzlC; cl00570
743718003504	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
743718003505	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
743718003506	tetramerization interface [polypeptide binding]; other site
743718003507	NAD(P) binding site [chemical binding]; other site
743718003508	catalytic residues [active]
743718003509	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
743718003510	dihydrodipicolinate synthase; Region: dapA; TIGR00674
743718003511	dimer interface [polypeptide binding]; other site
743718003512	active site
743718003513	catalytic residue [active]
743718003514	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
743718003515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743718003516	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
743718003517	WHG domain; Region: WHG; pfam13305
743718003518	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
743718003519	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
743718003520	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
743718003521	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
743718003522	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
743718003523	putative active site [active]
743718003524	putative metal binding site [ion binding]; other site
743718003525	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
743718003526	Competence-damaged protein; Region: CinA; pfam02464
743718003527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718003528	non-specific DNA binding site [nucleotide binding]; other site
743718003529	salt bridge; other site
743718003530	sequence-specific DNA binding site [nucleotide binding]; other site
743718003531	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
743718003532	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
743718003533	putative DNA binding site [nucleotide binding]; other site
743718003534	catalytic residue [active]
743718003535	putative H2TH interface [polypeptide binding]; other site
743718003536	putative catalytic residues [active]
743718003537	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
743718003538	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718003539	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718003540	ATP binding site [chemical binding]; other site
743718003541	putative Mg++ binding site [ion binding]; other site
743718003542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718003543	nucleotide binding region [chemical binding]; other site
743718003544	ATP-binding site [chemical binding]; other site
743718003545	DEAD/H associated; Region: DEAD_assoc; pfam08494
743718003546	DEAD/H associated; Region: DEAD_assoc; pfam08494
743718003547	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
743718003548	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743718003549	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
743718003550	recombinase A; Provisional; Region: recA; PRK09354
743718003551	recA bacterial DNA recombination protein; Region: RecA; cl17211
743718003552	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743718003553	protein-splicing catalytic site; other site
743718003554	thioester formation/cholesterol transfer; other site
743718003555	LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161
743718003556	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743718003557	recA bacterial DNA recombination protein; Region: RecA; cl17211
743718003558	protein-splicing catalytic site; other site
743718003559	recombination regulator RecX; Reviewed; Region: recX; PRK00117
743718003560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718003561	dimer interface [polypeptide binding]; other site
743718003562	conserved gate region; other site
743718003563	putative PBP binding loops; other site
743718003564	ABC-ATPase subunit interface; other site
743718003565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718003566	dimer interface [polypeptide binding]; other site
743718003567	conserved gate region; other site
743718003568	putative PBP binding loops; other site
743718003569	ABC-ATPase subunit interface; other site
743718003570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
743718003571	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
743718003572	substrate binding pocket [chemical binding]; other site
743718003573	membrane-bound complex binding site; other site
743718003574	hinge residues; other site
743718003575	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
743718003576	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
743718003577	Walker A/P-loop; other site
743718003578	ATP binding site [chemical binding]; other site
743718003579	Q-loop/lid; other site
743718003580	ABC transporter signature motif; other site
743718003581	Walker B; other site
743718003582	D-loop; other site
743718003583	H-loop/switch region; other site
743718003584	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
743718003585	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
743718003586	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743718003587	FeS/SAM binding site; other site
743718003588	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
743718003589	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
743718003590	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
743718003591	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
743718003592	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
743718003593	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
743718003594	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
743718003595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718003596	S-adenosylmethionine binding site [chemical binding]; other site
743718003597	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
743718003598	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
743718003599	HflX GTPase family; Region: HflX; cd01878
743718003600	G1 box; other site
743718003601	GTP/Mg2+ binding site [chemical binding]; other site
743718003602	Switch I region; other site
743718003603	G2 box; other site
743718003604	G3 box; other site
743718003605	Switch II region; other site
743718003606	G4 box; other site
743718003607	G5 box; other site
743718003608	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
743718003609	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
743718003610	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
743718003611	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
743718003612	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
743718003613	NAD binding site [chemical binding]; other site
743718003614	dimer interface [polypeptide binding]; other site
743718003615	substrate binding site [chemical binding]; other site
743718003616	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743718003617	LexA repressor; Validated; Region: PRK00215
743718003618	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
743718003619	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
743718003620	Catalytic site [active]
743718003621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743718003622	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
743718003623	ATP cone domain; Region: ATP-cone; pfam03477
743718003624	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
743718003625	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
743718003626	ligand binding site [chemical binding]; other site
743718003627	NAD binding site [chemical binding]; other site
743718003628	tetramer interface [polypeptide binding]; other site
743718003629	catalytic site [active]
743718003630	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
743718003631	L-serine binding site [chemical binding]; other site
743718003632	ACT domain interface; other site
743718003633	Part of AAA domain; Region: AAA_19; pfam13245
743718003634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718003635	active site
743718003636	phosphorylation site [posttranslational modification]
743718003637	intermolecular recognition site; other site
743718003638	dimerization interface [polypeptide binding]; other site
743718003639	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718003640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743718003641	dimerization interface [polypeptide binding]; other site
743718003642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718003643	dimer interface [polypeptide binding]; other site
743718003644	phosphorylation site [posttranslational modification]
743718003645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718003646	ATP binding site [chemical binding]; other site
743718003647	Mg2+ binding site [ion binding]; other site
743718003648	G-X-G motif; other site
743718003649	Response regulator receiver domain; Region: Response_reg; pfam00072
743718003650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718003651	active site
743718003652	phosphorylation site [posttranslational modification]
743718003653	intermolecular recognition site; other site
743718003654	dimerization interface [polypeptide binding]; other site
743718003655	PAC2 family; Region: PAC2; pfam09754
743718003656	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743718003657	DNA-binding site [nucleotide binding]; DNA binding site
743718003658	RNA-binding motif; other site
743718003659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743718003660	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
743718003661	active site
743718003662	DNA polymerase IV; Validated; Region: PRK02406
743718003663	DNA binding site [nucleotide binding]
743718003664	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
743718003665	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
743718003666	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
743718003667	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
743718003668	Protein of unknown function DUF58; Region: DUF58; pfam01882
743718003669	MoxR-like ATPases [General function prediction only]; Region: COG0714
743718003670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718003671	ATP binding site [chemical binding]; other site
743718003672	Walker A motif; other site
743718003673	Walker B motif; other site
743718003674	arginine finger; other site
743718003675	MraZ protein; Region: MraZ; pfam02381
743718003676	cell division protein MraZ; Reviewed; Region: PRK00326
743718003677	MraZ protein; Region: MraZ; pfam02381
743718003678	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
743718003679	MraW methylase family; Region: Methyltransf_5; cl17771
743718003680	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
743718003681	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
743718003682	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
743718003683	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
743718003684	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743718003685	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743718003686	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
743718003687	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743718003688	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743718003689	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743718003690	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
743718003691	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
743718003692	Mg++ binding site [ion binding]; other site
743718003693	putative catalytic motif [active]
743718003694	putative substrate binding site [chemical binding]; other site
743718003695	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
743718003696	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743718003697	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743718003698	cell division protein FtsW; Region: ftsW; TIGR02614
743718003699	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
743718003700	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718003701	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718003702	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
743718003703	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743718003704	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743718003705	Cell division protein FtsQ; Region: FtsQ; pfam03799
743718003706	cell division protein FtsZ; Validated; Region: PRK09330
743718003707	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
743718003708	nucleotide binding site [chemical binding]; other site
743718003709	SulA interaction site; other site
743718003710	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
743718003711	Protein of unknown function (DUF552); Region: DUF552; pfam04472
743718003712	YGGT family; Region: YGGT; cl00508
743718003713	DivIVA protein; Region: DivIVA; pfam05103
743718003714	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
743718003715	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
743718003716	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
743718003717	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
743718003718	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743718003719	RNA binding surface [nucleotide binding]; other site
743718003720	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
743718003721	active site
743718003722	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
743718003723	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
743718003724	active site
743718003725	PHP Thumb interface [polypeptide binding]; other site
743718003726	metal binding site [ion binding]; metal-binding site
743718003727	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
743718003728	generic binding surface II; other site
743718003729	generic binding surface I; other site
743718003730	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743718003731	nudix motif; other site
743718003732	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
743718003733	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718003734	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718003735	active site
743718003736	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743718003737	RNA binding surface [nucleotide binding]; other site
743718003738	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
743718003739	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
743718003740	NAD binding site [chemical binding]; other site
743718003741	dimerization interface [polypeptide binding]; other site
743718003742	product binding site; other site
743718003743	substrate binding site [chemical binding]; other site
743718003744	zinc binding site [ion binding]; other site
743718003745	catalytic residues [active]
743718003746	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718003747	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718003748	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718003749	ATP binding site [chemical binding]; other site
743718003750	putative Mg++ binding site [ion binding]; other site
743718003751	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718003752	nucleotide binding region [chemical binding]; other site
743718003753	ATP-binding site [chemical binding]; other site
743718003754	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
743718003755	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718003756	ATP binding site [chemical binding]; other site
743718003757	putative Mg++ binding site [ion binding]; other site
743718003758	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718003759	nucleotide binding region [chemical binding]; other site
743718003760	ATP-binding site [chemical binding]; other site
743718003761	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
743718003762	iron-sulfur cluster [ion binding]; other site
743718003763	[2Fe-2S] cluster binding site [ion binding]; other site
743718003764	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
743718003765	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718003766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718003767	homodimer interface [polypeptide binding]; other site
743718003768	catalytic residue [active]
743718003769	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
743718003770	4-fold oligomerization interface [polypeptide binding]; other site
743718003771	putative active site pocket [active]
743718003772	metal binding residues [ion binding]; metal-binding site
743718003773	3-fold/trimer interface [polypeptide binding]; other site
743718003774	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
743718003775	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
743718003776	putative active site [active]
743718003777	oxyanion strand; other site
743718003778	catalytic triad [active]
743718003779	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
743718003780	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
743718003781	catalytic residues [active]
743718003782	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
743718003783	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743718003784	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
743718003785	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
743718003786	tetramer interface [polypeptide binding]; other site
743718003787	heme binding pocket [chemical binding]; other site
743718003788	NADPH binding site [chemical binding]; other site
743718003789	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
743718003790	metal binding site 2 [ion binding]; metal-binding site
743718003791	putative DNA binding helix; other site
743718003792	metal binding site 1 [ion binding]; metal-binding site
743718003793	dimer interface [polypeptide binding]; other site
743718003794	structural Zn2+ binding site [ion binding]; other site
743718003795	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
743718003796	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
743718003797	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
743718003798	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
743718003799	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
743718003800	23S rRNA binding site [nucleotide binding]; other site
743718003801	L21 binding site [polypeptide binding]; other site
743718003802	L13 binding site [polypeptide binding]; other site
743718003803	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
743718003804	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
743718003805	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
743718003806	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
743718003807	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
743718003808	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
743718003809	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
743718003810	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
743718003811	dimer interface [polypeptide binding]; other site
743718003812	motif 1; other site
743718003813	active site
743718003814	motif 2; other site
743718003815	motif 3; other site
743718003816	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
743718003817	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
743718003818	putative tRNA-binding site [nucleotide binding]; other site
743718003819	B3/4 domain; Region: B3_4; pfam03483
743718003820	tRNA synthetase B5 domain; Region: B5; pfam03484
743718003821	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
743718003822	motif 1; other site
743718003823	dimer interface [polypeptide binding]; other site
743718003824	active site
743718003825	motif 2; other site
743718003826	motif 3; other site
743718003827	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
743718003828	short chain dehydrogenase; Provisional; Region: PRK12828
743718003829	classical (c) SDRs; Region: SDR_c; cd05233
743718003830	NAD(P) binding site [chemical binding]; other site
743718003831	active site
743718003832	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
743718003833	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
743718003834	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
743718003835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718003836	S-adenosylmethionine binding site [chemical binding]; other site
743718003837	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743718003838	ATP binding site [chemical binding]; other site
743718003839	Mg2+ binding site [ion binding]; other site
743718003840	G-X-G motif; other site
743718003841	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743718003842	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
743718003843	NADP binding site [chemical binding]; other site
743718003844	dimer interface [polypeptide binding]; other site
743718003845	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743718003846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743718003847	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743718003848	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
743718003849	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
743718003850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718003851	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
743718003852	heterotetramer interface [polypeptide binding]; other site
743718003853	active site pocket [active]
743718003854	cleavage site
743718003855	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
743718003856	feedback inhibition sensing region; other site
743718003857	homohexameric interface [polypeptide binding]; other site
743718003858	nucleotide binding site [chemical binding]; other site
743718003859	N-acetyl-L-glutamate binding site [chemical binding]; other site
743718003860	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
743718003861	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743718003862	inhibitor-cofactor binding pocket; inhibition site
743718003863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718003864	catalytic residue [active]
743718003865	ornithine carbamoyltransferase; Provisional; Region: PRK00779
743718003866	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
743718003867	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
743718003868	arginine repressor; Provisional; Region: PRK03341
743718003869	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
743718003870	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
743718003871	argininosuccinate synthase; Provisional; Region: PRK13820
743718003872	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
743718003873	ANP binding site [chemical binding]; other site
743718003874	Substrate Binding Site II [chemical binding]; other site
743718003875	Substrate Binding Site I [chemical binding]; other site
743718003876	argininosuccinate lyase; Provisional; Region: PRK00855
743718003877	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
743718003878	active sites [active]
743718003879	tetramer interface [polypeptide binding]; other site
743718003880	hypothetical protein; Provisional; Region: PRK06547
743718003881	AAA domain; Region: AAA_18; pfam13238
743718003882	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
743718003883	active site
743718003884	DNA binding site [nucleotide binding]
743718003885	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
743718003886	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
743718003887	active site
743718003888	HIGH motif; other site
743718003889	dimer interface [polypeptide binding]; other site
743718003890	KMSKS motif; other site
743718003891	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
743718003892	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
743718003893	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
743718003894	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
743718003895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718003896	S-adenosylmethionine binding site [chemical binding]; other site
743718003897	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
743718003898	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
743718003899	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
743718003900	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718003901	Walker A/P-loop; other site
743718003902	ATP binding site [chemical binding]; other site
743718003903	Q-loop/lid; other site
743718003904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718003905	ABC transporter signature motif; other site
743718003906	Walker B; other site
743718003907	D-loop; other site
743718003908	H-loop/switch region; other site
743718003909	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
743718003910	Thiamine pyrophosphokinase; Region: TPK; cl08415
743718003911	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
743718003912	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
743718003913	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743718003914	CTP synthetase; Validated; Region: pyrG; PRK05380
743718003915	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
743718003916	Catalytic site [active]
743718003917	active site
743718003918	UTP binding site [chemical binding]; other site
743718003919	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
743718003920	active site
743718003921	putative oxyanion hole; other site
743718003922	catalytic triad [active]
743718003923	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
743718003924	dimer interface [polypeptide binding]; other site
743718003925	active site
743718003926	ADP-ribose binding site [chemical binding]; other site
743718003927	nudix motif; other site
743718003928	metal binding site [ion binding]; metal-binding site
743718003929	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
743718003930	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718003931	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718003932	Walker A/P-loop; other site
743718003933	ATP binding site [chemical binding]; other site
743718003934	Q-loop/lid; other site
743718003935	ABC transporter signature motif; other site
743718003936	Walker B; other site
743718003937	D-loop; other site
743718003938	H-loop/switch region; other site
743718003939	Predicted transcriptional regulator [Transcription]; Region: COG2345
743718003940	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718003941	putative DNA binding site [nucleotide binding]; other site
743718003942	putative Zn2+ binding site [ion binding]; other site
743718003943	FeS assembly protein SufB; Region: sufB; TIGR01980
743718003944	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
743718003945	FeS assembly protein SufD; Region: sufD; TIGR01981
743718003946	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
743718003947	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
743718003948	[2Fe-2S] cluster binding site [ion binding]; other site
743718003949	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
743718003950	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
743718003951	Walker A/P-loop; other site
743718003952	ATP binding site [chemical binding]; other site
743718003953	Q-loop/lid; other site
743718003954	ABC transporter signature motif; other site
743718003955	Walker B; other site
743718003956	D-loop; other site
743718003957	H-loop/switch region; other site
743718003958	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
743718003959	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
743718003960	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718003961	catalytic residue [active]
743718003962	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
743718003963	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
743718003964	trimerization site [polypeptide binding]; other site
743718003965	active site
743718003966	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
743718003967	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
743718003968	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743718003969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718003970	Walker A/P-loop; other site
743718003971	ATP binding site [chemical binding]; other site
743718003972	Q-loop/lid; other site
743718003973	ABC transporter signature motif; other site
743718003974	Walker B; other site
743718003975	D-loop; other site
743718003976	H-loop/switch region; other site
743718003977	ABC transporter; Region: ABC_tran_2; pfam12848
743718003978	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718003979	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
743718003980	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
743718003981	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
743718003982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718003983	NAD(P) binding site [chemical binding]; other site
743718003984	active site
743718003985	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
743718003986	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
743718003987	NAD binding site [chemical binding]; other site
743718003988	homotetramer interface [polypeptide binding]; other site
743718003989	homodimer interface [polypeptide binding]; other site
743718003990	substrate binding site [chemical binding]; other site
743718003991	active site
743718003992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718003993	catalytic core [active]
743718003994	Isochorismatase family; Region: Isochorismatase; pfam00857
743718003995	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
743718003996	catalytic triad [active]
743718003997	conserved cis-peptide bond; other site
743718003998	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
743718003999	phosphoserine phosphatase SerB; Region: serB; TIGR00338
743718004000	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743718004001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718004002	motif II; other site
743718004003	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
743718004004	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
743718004005	ligand binding site; other site
743718004006	oligomer interface; other site
743718004007	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
743718004008	dimer interface [polypeptide binding]; other site
743718004009	N-terminal domain interface [polypeptide binding]; other site
743718004010	sulfate 1 binding site; other site
743718004011	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
743718004012	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
743718004013	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
743718004014	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
743718004015	Walker A/P-loop; other site
743718004016	ATP binding site [chemical binding]; other site
743718004017	Q-loop/lid; other site
743718004018	ABC transporter signature motif; other site
743718004019	Walker B; other site
743718004020	D-loop; other site
743718004021	H-loop/switch region; other site
743718004022	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
743718004023	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
743718004024	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
743718004025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718004026	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718004027	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004029	Walker A/P-loop; other site
743718004030	ATP binding site [chemical binding]; other site
743718004031	Q-loop/lid; other site
743718004032	ABC transporter signature motif; other site
743718004033	Walker B; other site
743718004034	D-loop; other site
743718004035	H-loop/switch region; other site
743718004036	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718004037	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004038	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
743718004039	Walker A/P-loop; other site
743718004040	ATP binding site [chemical binding]; other site
743718004041	Q-loop/lid; other site
743718004042	ABC transporter signature motif; other site
743718004043	Walker B; other site
743718004044	D-loop; other site
743718004045	H-loop/switch region; other site
743718004046	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
743718004047	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718004048	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
743718004049	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
743718004050	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743718004051	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718004052	Ligand Binding Site [chemical binding]; other site
743718004053	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718004054	Ligand Binding Site [chemical binding]; other site
743718004055	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
743718004056	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718004057	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
743718004058	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718004059	active site
743718004060	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
743718004061	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
743718004062	FAD binding pocket [chemical binding]; other site
743718004063	FAD binding motif [chemical binding]; other site
743718004064	phosphate binding motif [ion binding]; other site
743718004065	NAD binding pocket [chemical binding]; other site
743718004066	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
743718004067	putative deacylase active site [active]
743718004068	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
743718004069	substrate binding site [chemical binding]; other site
743718004070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718004071	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743718004072	NAD(P) binding site [chemical binding]; other site
743718004073	active site
743718004074	Y-family of DNA polymerases; Region: PolY; cl12025
743718004075	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
743718004076	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
743718004077	active site
743718004078	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
743718004079	generic binding surface I; other site
743718004080	generic binding surface II; other site
743718004081	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
743718004082	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
743718004083	active site
743718004084	catalytic site [active]
743718004085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718004086	dimerization interface [polypeptide binding]; other site
743718004087	putative DNA binding site [nucleotide binding]; other site
743718004088	putative Zn2+ binding site [ion binding]; other site
743718004089	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
743718004090	putative hydrophobic ligand binding site [chemical binding]; other site
743718004091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718004092	Coenzyme A binding pocket [chemical binding]; other site
743718004093	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
743718004094	ATP binding site [chemical binding]; other site
743718004095	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
743718004096	Glucose dehydrogenase; Region: glucose_DH; cd08230
743718004097	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743718004098	NADP binding site [chemical binding]; other site
743718004099	catalytic Zn binding site [ion binding]; other site
743718004100	structural Zn binding site [ion binding]; other site
743718004101	dimer interface [polypeptide binding]; other site
743718004102	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743718004103	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743718004104	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743718004105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718004106	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
743718004107	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
743718004108	active site
743718004109	Zn binding site [ion binding]; other site
743718004110	hypothetical protein; Provisional; Region: PRK07906
743718004111	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
743718004112	putative metal binding site [ion binding]; other site
743718004113	Fructosamine kinase; Region: Fructosamin_kin; cl17579
743718004114	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718004115	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718004116	active site
743718004117	catalytic tetrad [active]
743718004118	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
743718004119	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718004120	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
743718004121	active site
743718004122	HIGH motif; other site
743718004123	nucleotide binding site [chemical binding]; other site
743718004124	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718004125	active site
743718004126	KMSKS motif; other site
743718004127	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743718004128	tRNA binding surface [nucleotide binding]; other site
743718004129	anticodon binding site; other site
743718004130	PAC2 family; Region: PAC2; pfam09754
743718004131	Survival protein SurE; Region: SurE; pfam01975
743718004132	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743718004133	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718004134	substrate binding site [chemical binding]; other site
743718004135	ATP binding site [chemical binding]; other site
743718004136	classical (c) SDRs; Region: SDR_c; cd05233
743718004137	NAD(P) binding site [chemical binding]; other site
743718004138	active site
743718004139	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743718004140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718004141	NAD(P) binding site [chemical binding]; other site
743718004142	active site
743718004143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718004144	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
743718004145	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743718004146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718004147	motif II; other site
743718004148	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
743718004149	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
743718004150	Peptidase family M50; Region: Peptidase_M50; pfam02163
743718004151	active site
743718004152	putative substrate binding region [chemical binding]; other site
743718004153	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
743718004154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718004155	S-adenosylmethionine binding site [chemical binding]; other site
743718004156	proteasome ATPase; Region: pup_AAA; TIGR03689
743718004157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718004158	Walker A motif; other site
743718004159	ATP binding site [chemical binding]; other site
743718004160	Walker B motif; other site
743718004161	arginine finger; other site
743718004162	Pup-ligase protein; Region: Pup_ligase; cl15463
743718004163	Pup-ligase protein; Region: Pup_ligase; cl15463
743718004164	Pup-like protein; Region: Pup; pfam05639
743718004165	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
743718004166	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
743718004167	active site
743718004168	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
743718004169	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
743718004170	active site
743718004171	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
743718004172	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743718004173	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
743718004174	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
743718004175	substrate binding site [chemical binding]; other site
743718004176	glutamase interaction surface [polypeptide binding]; other site
743718004177	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743718004178	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004179	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004180	Walker A/P-loop; other site
743718004181	ATP binding site [chemical binding]; other site
743718004182	Q-loop/lid; other site
743718004183	ABC transporter signature motif; other site
743718004184	Walker B; other site
743718004185	D-loop; other site
743718004186	H-loop/switch region; other site
743718004187	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
743718004188	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004190	Walker A/P-loop; other site
743718004191	ATP binding site [chemical binding]; other site
743718004192	Q-loop/lid; other site
743718004193	ABC transporter signature motif; other site
743718004194	Walker B; other site
743718004195	D-loop; other site
743718004196	H-loop/switch region; other site
743718004197	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
743718004198	anthranilate synthase component I; Provisional; Region: PRK13571
743718004199	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
743718004200	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
743718004201	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
743718004202	active site
743718004203	ribulose/triose binding site [chemical binding]; other site
743718004204	phosphate binding site [ion binding]; other site
743718004205	substrate (anthranilate) binding pocket [chemical binding]; other site
743718004206	product (indole) binding pocket [chemical binding]; other site
743718004207	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
743718004208	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
743718004209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718004210	catalytic residue [active]
743718004211	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
743718004212	substrate binding site [chemical binding]; other site
743718004213	active site
743718004214	catalytic residues [active]
743718004215	heterodimer interface [polypeptide binding]; other site
743718004216	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
743718004217	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
743718004218	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
743718004219	active site
743718004220	dimer interface [polypeptide binding]; other site
743718004221	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
743718004222	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
743718004223	active site
743718004224	FMN binding site [chemical binding]; other site
743718004225	substrate binding site [chemical binding]; other site
743718004226	3Fe-4S cluster binding site [ion binding]; other site
743718004227	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
743718004228	domain interface; other site
743718004229	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
743718004230	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743718004231	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
743718004232	pyruvate kinase; Provisional; Region: PRK06247
743718004233	domain interfaces; other site
743718004234	active site
743718004235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718004236	Response regulator receiver domain; Region: Response_reg; pfam00072
743718004237	active site
743718004238	phosphorylation site [posttranslational modification]
743718004239	intermolecular recognition site; other site
743718004240	dimerization interface [polypeptide binding]; other site
743718004241	ANTAR domain; Region: ANTAR; pfam03861
743718004242	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
743718004243	CoenzymeA binding site [chemical binding]; other site
743718004244	subunit interaction site [polypeptide binding]; other site
743718004245	PHB binding site; other site
743718004246	DNA polymerase I; Provisional; Region: PRK05755
743718004247	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
743718004248	active site
743718004249	metal binding site 1 [ion binding]; metal-binding site
743718004250	putative 5' ssDNA interaction site; other site
743718004251	metal binding site 3; metal-binding site
743718004252	metal binding site 2 [ion binding]; metal-binding site
743718004253	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
743718004254	putative DNA binding site [nucleotide binding]; other site
743718004255	putative metal binding site [ion binding]; other site
743718004256	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
743718004257	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
743718004258	active site
743718004259	DNA binding site [nucleotide binding]
743718004260	catalytic site [active]
743718004261	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
743718004262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718004263	S-adenosylmethionine binding site [chemical binding]; other site
743718004264	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
743718004265	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
743718004266	RNA binding site [nucleotide binding]; other site
743718004267	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
743718004268	RNA binding site [nucleotide binding]; other site
743718004269	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743718004270	RNA binding site [nucleotide binding]; other site
743718004271	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
743718004272	RNA binding site [nucleotide binding]; other site
743718004273	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
743718004274	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004276	Walker A/P-loop; other site
743718004277	ATP binding site [chemical binding]; other site
743718004278	Q-loop/lid; other site
743718004279	ABC transporter signature motif; other site
743718004280	Walker B; other site
743718004281	D-loop; other site
743718004282	H-loop/switch region; other site
743718004283	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
743718004284	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
743718004285	CoA-binding site [chemical binding]; other site
743718004286	ATP-binding [chemical binding]; other site
743718004287	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
743718004288	putative substrate binding pocket [chemical binding]; other site
743718004289	AC domain interface; other site
743718004290	catalytic triad [active]
743718004291	AB domain interface; other site
743718004292	excinuclease ABC subunit B; Provisional; Region: PRK05298
743718004293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718004294	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718004295	nucleotide binding region [chemical binding]; other site
743718004296	ATP-binding site [chemical binding]; other site
743718004297	Ultra-violet resistance protein B; Region: UvrB; pfam12344
743718004298	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
743718004299	Integral membrane protein TerC family; Region: TerC; cl10468
743718004300	YCII-related domain; Region: YCII; cl00999
743718004301	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
743718004302	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
743718004303	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743718004304	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743718004305	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
743718004306	OsmC-like protein; Region: OsmC; cl00767
743718004307	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
743718004308	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
743718004309	GIY-YIG motif/motif A; other site
743718004310	active site
743718004311	catalytic site [active]
743718004312	putative DNA binding site [nucleotide binding]; other site
743718004313	metal binding site [ion binding]; metal-binding site
743718004314	UvrB/uvrC motif; Region: UVR; pfam02151
743718004315	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
743718004316	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
743718004317	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
743718004318	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
743718004319	putative substrate binding pocket [chemical binding]; other site
743718004320	dimer interface [polypeptide binding]; other site
743718004321	phosphate binding site [ion binding]; other site
743718004322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
743718004323	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
743718004324	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
743718004325	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
743718004326	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
743718004327	Phosphoglycerate kinase; Region: PGK; pfam00162
743718004328	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
743718004329	substrate binding site [chemical binding]; other site
743718004330	hinge regions; other site
743718004331	ADP binding site [chemical binding]; other site
743718004332	catalytic site [active]
743718004333	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
743718004334	triosephosphate isomerase; Provisional; Region: PRK14567
743718004335	substrate binding site [chemical binding]; other site
743718004336	dimer interface [polypeptide binding]; other site
743718004337	catalytic triad [active]
743718004338	Preprotein translocase SecG subunit; Region: SecG; pfam03840
743718004339	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
743718004340	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
743718004341	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
743718004342	putative active site [active]
743718004343	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
743718004344	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
743718004345	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
743718004346	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
743718004347	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
743718004348	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
743718004349	putative active site [active]
743718004350	transaldolase; Provisional; Region: PRK03903
743718004351	catalytic residue [active]
743718004352	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
743718004353	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
743718004354	TPP-binding site [chemical binding]; other site
743718004355	dimer interface [polypeptide binding]; other site
743718004356	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743718004357	PYR/PP interface [polypeptide binding]; other site
743718004358	dimer interface [polypeptide binding]; other site
743718004359	TPP binding site [chemical binding]; other site
743718004360	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743718004361	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
743718004362	UbiA prenyltransferase family; Region: UbiA; pfam01040
743718004363	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
743718004364	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
743718004365	active site
743718004366	Int/Topo IB signature motif; other site
743718004367	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
743718004368	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743718004369	P-loop; other site
743718004370	Magnesium ion binding site [ion binding]; other site
743718004371	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743718004372	Magnesium ion binding site [ion binding]; other site
743718004373	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
743718004374	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
743718004375	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
743718004376	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743718004377	RNA binding surface [nucleotide binding]; other site
743718004378	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
743718004379	active site
743718004380	cytidylate kinase; Provisional; Region: cmk; PRK00023
743718004381	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
743718004382	CMP-binding site; other site
743718004383	The sites determining sugar specificity; other site
743718004384	GTP-binding protein Der; Reviewed; Region: PRK03003
743718004385	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
743718004386	G1 box; other site
743718004387	GTP/Mg2+ binding site [chemical binding]; other site
743718004388	Switch I region; other site
743718004389	G2 box; other site
743718004390	Switch II region; other site
743718004391	G3 box; other site
743718004392	G4 box; other site
743718004393	G5 box; other site
743718004394	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
743718004395	G1 box; other site
743718004396	GTP/Mg2+ binding site [chemical binding]; other site
743718004397	Switch I region; other site
743718004398	G2 box; other site
743718004399	G3 box; other site
743718004400	Switch II region; other site
743718004401	G4 box; other site
743718004402	G5 box; other site
743718004403	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
743718004404	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
743718004405	catalytic motif [active]
743718004406	Zn binding site [ion binding]; other site
743718004407	RibD C-terminal domain; Region: RibD_C; pfam01872
743718004408	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
743718004409	Lumazine binding domain; Region: Lum_binding; pfam00677
743718004410	Lumazine binding domain; Region: Lum_binding; pfam00677
743718004411	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
743718004412	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
743718004413	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
743718004414	dimerization interface [polypeptide binding]; other site
743718004415	active site
743718004416	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
743718004417	homopentamer interface [polypeptide binding]; other site
743718004418	active site
743718004419	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
743718004420	active site
743718004421	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
743718004422	dimerization interface [polypeptide binding]; other site
743718004423	Acylphosphatase; Region: Acylphosphatase; pfam00708
743718004424	Phospholipid methyltransferase; Region: PEMT; cl17370
743718004425	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
743718004426	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
743718004427	active site
743718004428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718004429	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718004430	Coenzyme A binding pocket [chemical binding]; other site
743718004431	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
743718004432	substrate binding site [chemical binding]; other site
743718004433	dimer interface [polypeptide binding]; other site
743718004434	ATP binding site [chemical binding]; other site
743718004435	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004436	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
743718004437	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004438	Walker A/P-loop; other site
743718004439	ATP binding site [chemical binding]; other site
743718004440	Q-loop/lid; other site
743718004441	ABC transporter signature motif; other site
743718004442	Walker B; other site
743718004443	D-loop; other site
743718004444	H-loop/switch region; other site
743718004445	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718004446	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
743718004447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004448	Walker A/P-loop; other site
743718004449	ATP binding site [chemical binding]; other site
743718004450	Q-loop/lid; other site
743718004451	ABC transporter signature motif; other site
743718004452	Walker B; other site
743718004453	D-loop; other site
743718004454	H-loop/switch region; other site
743718004455	Lipase maturation factor; Region: LMF1; pfam06762
743718004456	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718004457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743718004458	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
743718004459	putative dimerization interface [polypeptide binding]; other site
743718004460	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
743718004461	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718004462	active site
743718004463	hypothetical protein; Provisional; Region: PRK11568
743718004464	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
743718004465	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
743718004466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718004467	Coenzyme A binding pocket [chemical binding]; other site
743718004468	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
743718004469	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
743718004470	dimerization interface [polypeptide binding]; other site
743718004471	DPS ferroxidase diiron center [ion binding]; other site
743718004472	ion pore; other site
743718004473	MoxR-like ATPases [General function prediction only]; Region: COG0714
743718004474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718004475	Walker A motif; other site
743718004476	ATP binding site [chemical binding]; other site
743718004477	Walker B motif; other site
743718004478	arginine finger; other site
743718004479	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
743718004480	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
743718004481	Predicted transcriptional regulator [Transcription]; Region: COG2378
743718004482	WYL domain; Region: WYL; pfam13280
743718004483	Predicted transcriptional regulator [Transcription]; Region: COG2378
743718004484	WYL domain; Region: WYL; pfam13280
743718004485	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
743718004486	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
743718004487	diacylglycerol kinase; Reviewed; Region: PRK11914
743718004488	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718004489	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718004490	ATP binding site [chemical binding]; other site
743718004491	putative Mg++ binding site [ion binding]; other site
743718004492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718004493	nucleotide binding region [chemical binding]; other site
743718004494	ATP-binding site [chemical binding]; other site
743718004495	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
743718004496	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
743718004497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743718004498	active site
743718004499	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
743718004500	putative active site [active]
743718004501	catalytic triad [active]
743718004502	putative dimer interface [polypeptide binding]; other site
743718004503	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
743718004504	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
743718004505	Ligand binding site; other site
743718004506	DXD motif; other site
743718004507	Putative Catalytic site; other site
743718004508	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
743718004509	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
743718004510	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
743718004511	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718004512	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
743718004513	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743718004514	UDP-glucose 4-epimerase; Region: PLN02240
743718004515	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
743718004516	NAD binding site [chemical binding]; other site
743718004517	homodimer interface [polypeptide binding]; other site
743718004518	active site
743718004519	substrate binding site [chemical binding]; other site
743718004520	ribonuclease Z; Reviewed; Region: PRK00055
743718004521	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
743718004522	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
743718004523	hexamer interface [polypeptide binding]; other site
743718004524	ligand binding site [chemical binding]; other site
743718004525	putative active site [active]
743718004526	NAD(P) binding site [chemical binding]; other site
743718004527	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743718004528	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
743718004529	AsnC family; Region: AsnC_trans_reg; pfam01037
743718004530	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
743718004531	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718004532	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
743718004533	catalytic site [active]
743718004534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
743718004535	PAS domain; Region: PAS_9; pfam13426
743718004536	putative active site [active]
743718004537	heme pocket [chemical binding]; other site
743718004538	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718004539	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
743718004540	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
743718004541	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
743718004542	MOSC domain; Region: MOSC; pfam03473
743718004543	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
743718004544	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
743718004545	Malic enzyme, N-terminal domain; Region: malic; pfam00390
743718004546	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
743718004547	NAD(P) binding pocket [chemical binding]; other site
743718004548	Domain of unknown function (DUF385); Region: DUF385; cl04387
743718004549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004550	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
743718004551	Walker A/P-loop; other site
743718004552	ATP binding site [chemical binding]; other site
743718004553	Q-loop/lid; other site
743718004554	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743718004555	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718004556	Walker A/P-loop; other site
743718004557	ATP binding site [chemical binding]; other site
743718004558	Q-loop/lid; other site
743718004559	ABC transporter signature motif; other site
743718004560	Walker B; other site
743718004561	D-loop; other site
743718004562	H-loop/switch region; other site
743718004563	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743718004564	homotrimer interaction site [polypeptide binding]; other site
743718004565	putative active site [active]
743718004566	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718004567	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
743718004568	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743718004569	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
743718004570	active site
743718004571	DNA binding site [nucleotide binding]
743718004572	Int/Topo IB signature motif; other site
743718004573	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
743718004574	PLD-like domain; Region: PLDc_2; pfam13091
743718004575	putative active site [active]
743718004576	catalytic site [active]
743718004577	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
743718004578	PLD-like domain; Region: PLDc_2; pfam13091
743718004579	putative active site [active]
743718004580	catalytic site [active]
743718004581	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743718004582	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
743718004583	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
743718004584	DNA binding residues [nucleotide binding]
743718004585	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
743718004586	putative dimer interface [polypeptide binding]; other site
743718004587	Bifunctional nuclease; Region: DNase-RNase; pfam02577
743718004588	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
743718004589	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743718004590	DNA binding residues [nucleotide binding]
743718004591	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
743718004592	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
743718004593	phosphopeptide binding site; other site
743718004594	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
743718004595	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
743718004596	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
743718004597	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
743718004598	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
743718004599	helicase 45; Provisional; Region: PTZ00424
743718004600	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743718004601	ATP binding site [chemical binding]; other site
743718004602	Mg++ binding site [ion binding]; other site
743718004603	motif III; other site
743718004604	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718004605	nucleotide binding region [chemical binding]; other site
743718004606	ATP-binding site [chemical binding]; other site
743718004607	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
743718004608	putative RNA binding site [nucleotide binding]; other site
743718004609	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
743718004610	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
743718004611	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
743718004612	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
743718004613	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
743718004614	homodimer interface [polypeptide binding]; other site
743718004615	putative metal binding site [ion binding]; other site
743718004616	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
743718004617	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
743718004618	substrate binding site [chemical binding]; other site
743718004619	hexamer interface [polypeptide binding]; other site
743718004620	metal binding site [ion binding]; metal-binding site
743718004621	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
743718004622	HipA N-terminal domain; Region: Couple_hipA; pfam13657
743718004623	HipA-like N-terminal domain; Region: HipA_N; pfam07805
743718004624	HipA-like C-terminal domain; Region: HipA_C; pfam07804
743718004625	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743718004626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718004627	non-specific DNA binding site [nucleotide binding]; other site
743718004628	salt bridge; other site
743718004629	sequence-specific DNA binding site [nucleotide binding]; other site
743718004630	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
743718004631	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
743718004632	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
743718004633	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
743718004634	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
743718004635	putative active site [active]
743718004636	substrate binding site [chemical binding]; other site
743718004637	putative cosubstrate binding site; other site
743718004638	catalytic site [active]
743718004639	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
743718004640	substrate binding site [chemical binding]; other site
743718004641	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
743718004642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718004643	primosome assembly protein PriA; Provisional; Region: PRK14873
743718004644	S-adenosylmethionine synthetase; Validated; Region: PRK05250
743718004645	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
743718004646	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
743718004647	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
743718004648	Flavoprotein; Region: Flavoprotein; pfam02441
743718004649	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
743718004650	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
743718004651	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
743718004652	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
743718004653	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
743718004654	catalytic site [active]
743718004655	G-X2-G-X-G-K; other site
743718004656	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
743718004657	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
743718004658	active site
743718004659	dimer interface [polypeptide binding]; other site
743718004660	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
743718004661	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743718004662	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743718004663	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
743718004664	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743718004665	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743718004666	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
743718004667	IMP binding site; other site
743718004668	dimer interface [polypeptide binding]; other site
743718004669	interdomain contacts; other site
743718004670	partial ornithine binding site; other site
743718004671	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
743718004672	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
743718004673	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
743718004674	catalytic site [active]
743718004675	subunit interface [polypeptide binding]; other site
743718004676	dihydroorotase; Validated; Region: pyrC; PRK09357
743718004677	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
743718004678	active site
743718004679	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
743718004680	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
743718004681	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
743718004682	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
743718004683	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718004684	active site
743718004685	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
743718004686	putative RNA binding site [nucleotide binding]; other site
743718004687	elongation factor P; Validated; Region: PRK00529
743718004688	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
743718004689	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
743718004690	RNA binding site [nucleotide binding]; other site
743718004691	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
743718004692	RNA binding site [nucleotide binding]; other site
743718004693	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
743718004694	Dehydroquinase class II; Region: DHquinase_II; pfam01220
743718004695	trimer interface [polypeptide binding]; other site
743718004696	active site
743718004697	dimer interface [polypeptide binding]; other site
743718004698	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
743718004699	FAD binding domain; Region: FAD_binding_4; pfam01565
743718004700	Berberine and berberine like; Region: BBE; pfam08031
743718004701	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718004702	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
743718004703	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743718004704	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
743718004705	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
743718004706	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743718004707	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
743718004708	putative active site [active]
743718004709	catalytic site [active]
743718004710	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743718004711	putative metal binding site [ion binding]; other site
743718004712	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
743718004713	dimer interface [polypeptide binding]; other site
743718004714	active site
743718004715	metal binding site [ion binding]; metal-binding site
743718004716	shikimate kinase; Reviewed; Region: aroK; PRK00131
743718004717	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
743718004718	ADP binding site [chemical binding]; other site
743718004719	magnesium binding site [ion binding]; other site
743718004720	putative shikimate binding site; other site
743718004721	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
743718004722	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
743718004723	Tetramer interface [polypeptide binding]; other site
743718004724	active site
743718004725	FMN-binding site [chemical binding]; other site
743718004726	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
743718004727	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
743718004728	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
743718004729	shikimate binding site; other site
743718004730	NAD(P) binding site [chemical binding]; other site
743718004731	YceG-like family; Region: YceG; pfam02618
743718004732	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
743718004733	dimerization interface [polypeptide binding]; other site
743718004734	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
743718004735	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
743718004736	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
743718004737	motif 1; other site
743718004738	active site
743718004739	motif 2; other site
743718004740	motif 3; other site
743718004741	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
743718004742	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
743718004743	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
743718004744	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743718004745	RNA binding surface [nucleotide binding]; other site
743718004746	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
743718004747	recombination factor protein RarA; Reviewed; Region: PRK13342
743718004748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718004749	Walker A motif; other site
743718004750	ATP binding site [chemical binding]; other site
743718004751	Walker B motif; other site
743718004752	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
743718004753	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718004754	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
743718004755	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
743718004756	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
743718004757	dimer interface [polypeptide binding]; other site
743718004758	anticodon binding site; other site
743718004759	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
743718004760	homodimer interface [polypeptide binding]; other site
743718004761	motif 1; other site
743718004762	active site
743718004763	motif 2; other site
743718004764	GAD domain; Region: GAD; pfam02938
743718004765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
743718004766	active site
743718004767	motif 3; other site
743718004768	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
743718004769	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
743718004770	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743718004771	protein-splicing catalytic site; other site
743718004772	thioester formation/cholesterol transfer; other site
743718004773	Radical SAM superfamily; Region: Radical_SAM; pfam04055
743718004774	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
743718004775	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
743718004776	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
743718004777	dimer interface [polypeptide binding]; other site
743718004778	motif 1; other site
743718004779	active site
743718004780	motif 2; other site
743718004781	motif 3; other site
743718004782	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
743718004783	anticodon binding site; other site
743718004784	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
743718004785	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
743718004786	active site
743718004787	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
743718004788	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
743718004789	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
743718004790	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
743718004791	nucleotide binding site [chemical binding]; other site
743718004792	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743718004793	RibD C-terminal domain; Region: RibD_C; cl17279
743718004794	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
743718004795	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
743718004796	active site
743718004797	DNA binding site [nucleotide binding]
743718004798	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
743718004799	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
743718004800	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743718004801	Zn2+ binding site [ion binding]; other site
743718004802	Mg2+ binding site [ion binding]; other site
743718004803	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
743718004804	synthetase active site [active]
743718004805	NTP binding site [chemical binding]; other site
743718004806	metal binding site [ion binding]; metal-binding site
743718004807	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
743718004808	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
743718004809	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718004810	active site
743718004811	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
743718004812	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
743718004813	Protein export membrane protein; Region: SecD_SecF; pfam02355
743718004814	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
743718004815	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
743718004816	Preprotein translocase subunit; Region: YajC; pfam02699
743718004817	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
743718004818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718004819	Walker A motif; other site
743718004820	ATP binding site [chemical binding]; other site
743718004821	Walker B motif; other site
743718004822	arginine finger; other site
743718004823	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
743718004824	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
743718004825	RuvA N terminal domain; Region: RuvA_N; pfam01330
743718004826	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
743718004827	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
743718004828	active site
743718004829	putative DNA-binding cleft [nucleotide binding]; other site
743718004830	dimer interface [polypeptide binding]; other site
743718004831	hypothetical protein; Validated; Region: PRK00110
743718004832	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
743718004833	predicted active site [active]
743718004834	catalytic triad [active]
743718004835	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743718004836	nudix motif; other site
743718004837	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
743718004838	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
743718004839	active site
743718004840	multimer interface [polypeptide binding]; other site
743718004841	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
743718004842	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718004843	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
743718004844	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
743718004845	putative acyl-acceptor binding pocket; other site
743718004846	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
743718004847	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
743718004848	nucleotide binding site/active site [active]
743718004849	HIT family signature motif; other site
743718004850	catalytic residue [active]
743718004851	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
743718004852	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
743718004853	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
743718004854	active site
743718004855	dimer interface [polypeptide binding]; other site
743718004856	motif 1; other site
743718004857	motif 2; other site
743718004858	motif 3; other site
743718004859	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
743718004860	anticodon binding site; other site
743718004861	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
743718004862	Fe-S cluster binding site [ion binding]; other site
743718004863	DNA binding site [nucleotide binding]
743718004864	active site
743718004865	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743718004866	DinB superfamily; Region: DinB_2; pfam12867
743718004867	Haemolytic domain; Region: Haemolytic; cl00506
743718004868	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743718004869	active site
743718004870	Zn binding site [ion binding]; other site
743718004871	YCII-related domain; Region: YCII; cl00999
743718004872	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
743718004873	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
743718004874	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
743718004875	PYR/PP interface [polypeptide binding]; other site
743718004876	dimer interface [polypeptide binding]; other site
743718004877	TPP binding site [chemical binding]; other site
743718004878	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
743718004879	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
743718004880	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
743718004881	TPP-binding site [chemical binding]; other site
743718004882	metabolite-proton symporter; Region: 2A0106; TIGR00883
743718004883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718004884	putative substrate translocation pore; other site
743718004885	hypothetical protein; Provisional; Region: PRK12764
743718004886	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
743718004887	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
743718004888	Transcriptional regulators [Transcription]; Region: GntR; COG1802
743718004889	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718004890	DNA-binding site [nucleotide binding]; DNA binding site
743718004891	FCD domain; Region: FCD; pfam07729
743718004892	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
743718004893	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
743718004894	NAD binding site [chemical binding]; other site
743718004895	catalytic residues [active]
743718004896	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
743718004897	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
743718004898	tetramer interface [polypeptide binding]; other site
743718004899	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
743718004900	tetramer interface [polypeptide binding]; other site
743718004901	active site
743718004902	metal binding site [ion binding]; metal-binding site
743718004903	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
743718004904	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
743718004905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718004906	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
743718004907	NAD(P) binding site [chemical binding]; other site
743718004908	active site
743718004909	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743718004910	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743718004911	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
743718004912	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743718004913	catalytic loop [active]
743718004914	iron binding site [ion binding]; other site
743718004915	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
743718004916	L-aspartate oxidase; Provisional; Region: PRK06175
743718004917	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
743718004918	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718004919	anti sigma factor interaction site; other site
743718004920	regulatory phosphorylation site [posttranslational modification]; other site
743718004921	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743718004922	salt bridge; other site
743718004923	non-specific DNA binding site [nucleotide binding]; other site
743718004924	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743718004925	sequence-specific DNA binding site [nucleotide binding]; other site
743718004926	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
743718004927	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
743718004928	active site
743718004929	metal binding site [ion binding]; metal-binding site
743718004930	homotetramer interface [polypeptide binding]; other site
743718004931	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
743718004932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743718004933	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
743718004934	Thioredoxin; Region: Thioredoxin_4; pfam13462
743718004935	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
743718004936	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
743718004937	active site
743718004938	metal binding site [ion binding]; metal-binding site
743718004939	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
743718004940	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
743718004941	FAD binding pocket [chemical binding]; other site
743718004942	conserved FAD binding motif [chemical binding]; other site
743718004943	phosphate binding motif [ion binding]; other site
743718004944	beta-alpha-beta structure motif; other site
743718004945	NAD binding pocket [chemical binding]; other site
743718004946	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
743718004947	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
743718004948	Moco binding site; other site
743718004949	metal coordination site [ion binding]; other site
743718004950	hypothetical protein; Provisional; Region: PRK07945
743718004951	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
743718004952	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
743718004953	active site
743718004954	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
743718004955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718004956	NAD(P) binding site [chemical binding]; other site
743718004957	active site
743718004958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718004959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718004960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718004961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718004962	ATP binding site [chemical binding]; other site
743718004963	Mg2+ binding site [ion binding]; other site
743718004964	G-X-G motif; other site
743718004965	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718004966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718004967	active site
743718004968	phosphorylation site [posttranslational modification]
743718004969	intermolecular recognition site; other site
743718004970	dimerization interface [polypeptide binding]; other site
743718004971	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718004972	DNA binding residues [nucleotide binding]
743718004973	dimerization interface [polypeptide binding]; other site
743718004974	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
743718004975	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
743718004976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718004977	dimer interface [polypeptide binding]; other site
743718004978	phosphorylation site [posttranslational modification]
743718004979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718004980	ATP binding site [chemical binding]; other site
743718004981	Mg2+ binding site [ion binding]; other site
743718004982	G-X-G motif; other site
743718004983	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
743718004984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718004985	active site
743718004986	phosphorylation site [posttranslational modification]
743718004987	intermolecular recognition site; other site
743718004988	dimerization interface [polypeptide binding]; other site
743718004989	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718004990	DNA binding site [nucleotide binding]
743718004991	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718004992	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718004993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718004994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743718004995	putative substrate translocation pore; other site
743718004996	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
743718004997	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743718004998	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
743718004999	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
743718005000	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
743718005001	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
743718005002	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718005003	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
743718005004	substrate binding site [chemical binding]; other site
743718005005	dimer interface [polypeptide binding]; other site
743718005006	ATP binding site [chemical binding]; other site
743718005007	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
743718005008	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
743718005009	ligand binding site [chemical binding]; other site
743718005010	dimerization interface [polypeptide binding]; other site
743718005011	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718005012	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718005013	TM-ABC transporter signature motif; other site
743718005014	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
743718005015	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718005016	Walker A/P-loop; other site
743718005017	ATP binding site [chemical binding]; other site
743718005018	Q-loop/lid; other site
743718005019	ABC transporter signature motif; other site
743718005020	Walker B; other site
743718005021	D-loop; other site
743718005022	H-loop/switch region; other site
743718005023	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743718005024	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
743718005025	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
743718005026	active site
743718005027	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718005028	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718005029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718005030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718005031	putative PBP binding loops; other site
743718005032	ABC-ATPase subunit interface; other site
743718005033	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718005034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718005035	dimer interface [polypeptide binding]; other site
743718005036	conserved gate region; other site
743718005037	putative PBP binding loops; other site
743718005038	ABC-ATPase subunit interface; other site
743718005039	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
743718005040	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743718005041	nucleotide binding site [chemical binding]; other site
743718005042	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
743718005043	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718005044	transketolase; Reviewed; Region: PRK05899
743718005045	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
743718005046	TPP-binding site [chemical binding]; other site
743718005047	dimer interface [polypeptide binding]; other site
743718005048	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
743718005049	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743718005050	PYR/PP interface [polypeptide binding]; other site
743718005051	dimer interface [polypeptide binding]; other site
743718005052	TPP binding site [chemical binding]; other site
743718005053	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743718005054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743718005055	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
743718005056	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
743718005057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
743718005058	Transposase; Region: HTH_Tnp_1; cl17663
743718005059	Septum formation initiator; Region: DivIC; cl17659
743718005060	HTH-like domain; Region: HTH_21; pfam13276
743718005061	Integrase core domain; Region: rve; pfam00665
743718005062	Integrase core domain; Region: rve_3; pfam13683
743718005063	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
743718005064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743718005065	DNA-binding interface [nucleotide binding]; DNA binding site
743718005066	Integrase core domain; Region: rve; pfam00665
743718005067	Integrase core domain; Region: rve_3; cl15866
743718005068	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
743718005069	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
743718005070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718005071	catalytic residue [active]
743718005072	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
743718005073	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
743718005074	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
743718005075	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
743718005076	RibD C-terminal domain; Region: RibD_C; cl17279
743718005077	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
743718005078	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
743718005079	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
743718005080	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
743718005081	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
743718005082	active site
743718005083	catalytic site [active]
743718005084	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
743718005085	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
743718005086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
743718005087	RibD C-terminal domain; Region: RibD_C; cl17279
743718005088	aspartate racemase; Region: asp_race; TIGR00035
743718005089	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
743718005090	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
743718005091	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
743718005092	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
743718005093	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
743718005094	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
743718005095	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
743718005096	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
743718005097	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
743718005098	active site
743718005099	catalytic site [active]
743718005100	substrate binding site [chemical binding]; other site
743718005101	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
743718005102	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
743718005103	dimer interface [polypeptide binding]; other site
743718005104	active site
743718005105	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743718005106	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
743718005107	substrate binding site [chemical binding]; other site
743718005108	oxyanion hole (OAH) forming residues; other site
743718005109	trimer interface [polypeptide binding]; other site
743718005110	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
743718005111	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
743718005112	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
743718005113	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
743718005114	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
743718005115	active site
743718005116	catalytic triad [active]
743718005117	oxyanion hole [active]
743718005118	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
743718005119	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
743718005120	TPP-binding site; other site
743718005121	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743718005122	PYR/PP interface [polypeptide binding]; other site
743718005123	dimer interface [polypeptide binding]; other site
743718005124	TPP binding site [chemical binding]; other site
743718005125	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743718005126	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
743718005127	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
743718005128	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743718005129	phosphate binding site [ion binding]; other site
743718005130	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
743718005131	putative active site [active]
743718005132	putative CoA binding site [chemical binding]; other site
743718005133	nudix motif; other site
743718005134	metal binding site [ion binding]; metal-binding site
743718005135	Phosphotransferase enzyme family; Region: APH; pfam01636
743718005136	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
743718005137	active site
743718005138	substrate binding site [chemical binding]; other site
743718005139	ATP binding site [chemical binding]; other site
743718005140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718005141	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718005142	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718005143	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
743718005144	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
743718005145	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718005146	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743718005147	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718005148	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718005149	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718005150	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743718005151	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
743718005152	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
743718005153	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
743718005154	aconitate hydratase; Validated; Region: PRK09277
743718005155	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
743718005156	substrate binding site [chemical binding]; other site
743718005157	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
743718005158	ligand binding site [chemical binding]; other site
743718005159	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
743718005160	substrate binding site [chemical binding]; other site
743718005161	TRAM domain; Region: TRAM; pfam01938
743718005162	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
743718005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718005164	S-adenosylmethionine binding site [chemical binding]; other site
743718005165	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
743718005166	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
743718005167	TrkA-N domain; Region: TrkA_N; pfam02254
743718005168	TrkA-C domain; Region: TrkA_C; pfam02080
743718005169	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
743718005170	TrkA-N domain; Region: TrkA_N; pfam02254
743718005171	TrkA-C domain; Region: TrkA_C; pfam02080
743718005172	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
743718005173	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
743718005174	ssDNA binding site; other site
743718005175	generic binding surface II; other site
743718005176	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
743718005177	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
743718005178	trimer interface [polypeptide binding]; other site
743718005179	active site
743718005180	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
743718005181	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
743718005182	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
743718005183	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
743718005184	active site
743718005185	Predicted membrane protein [Function unknown]; Region: COG2860
743718005186	UPF0126 domain; Region: UPF0126; pfam03458
743718005187	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
743718005188	thymidine kinase; Provisional; Region: PRK04296
743718005189	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743718005190	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743718005191	CoA binding domain; Region: CoA_binding; cl17356
743718005192	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
743718005193	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
743718005194	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
743718005195	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
743718005196	CAP-like domain; other site
743718005197	active site
743718005198	primary dimer interface [polypeptide binding]; other site
743718005199	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718005200	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743718005201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718005202	Coenzyme A binding pocket [chemical binding]; other site
743718005203	YhhN-like protein; Region: YhhN; pfam07947
743718005204	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
743718005205	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
743718005206	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
743718005207	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
743718005208	substrate binding pocket [chemical binding]; other site
743718005209	dimer interface [polypeptide binding]; other site
743718005210	inhibitor binding site; inhibition site
743718005211	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
743718005212	B12 binding site [chemical binding]; other site
743718005213	cobalt ligand [ion binding]; other site
743718005214	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
743718005215	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
743718005216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718005217	ATP binding site [chemical binding]; other site
743718005218	Mg2+ binding site [ion binding]; other site
743718005219	G-X-G motif; other site
743718005220	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
743718005221	anchoring element; other site
743718005222	dimer interface [polypeptide binding]; other site
743718005223	ATP binding site [chemical binding]; other site
743718005224	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
743718005225	active site
743718005226	metal binding site [ion binding]; metal-binding site
743718005227	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
743718005228	FAD binding domain; Region: FAD_binding_4; pfam01565
743718005229	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
743718005230	Berberine and berberine like; Region: BBE; pfam08031
743718005231	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
743718005232	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
743718005233	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718005234	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
743718005235	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718005236	DNA binding residues [nucleotide binding]
743718005237	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718005238	Ligand Binding Site [chemical binding]; other site
743718005239	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
743718005240	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
743718005241	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
743718005242	substrate binding pocket [chemical binding]; other site
743718005243	chain length determination region; other site
743718005244	substrate-Mg2+ binding site; other site
743718005245	catalytic residues [active]
743718005246	aspartate-rich region 1; other site
743718005247	active site lid residues [active]
743718005248	aspartate-rich region 2; other site
743718005249	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743718005250	Catalytic domain of Protein Kinases; Region: PKc; cd00180
743718005251	active site
743718005252	ATP binding site [chemical binding]; other site
743718005253	substrate binding site [chemical binding]; other site
743718005254	activation loop (A-loop); other site
743718005255	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718005256	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718005257	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718005258	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718005259	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
743718005260	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
743718005261	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
743718005262	active site
743718005263	ADP/pyrophosphate binding site [chemical binding]; other site
743718005264	allosteric effector site; other site
743718005265	dimerization interface [polypeptide binding]; other site
743718005266	fructose-1,6-bisphosphate binding site; other site
743718005267	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743718005268	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
743718005269	putative acyl-acceptor binding pocket; other site
743718005270	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
743718005271	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743718005272	nucleotide binding site [chemical binding]; other site
743718005273	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
743718005274	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
743718005275	acyl-activating enzyme (AAE) consensus motif; other site
743718005276	putative AMP binding site [chemical binding]; other site
743718005277	putative active site [active]
743718005278	putative CoA binding site [chemical binding]; other site
743718005279	hypothetical protein; Validated; Region: PRK07883
743718005280	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743718005281	active site
743718005282	catalytic site [active]
743718005283	substrate binding site [chemical binding]; other site
743718005284	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
743718005285	GIY-YIG motif/motif A; other site
743718005286	active site
743718005287	catalytic site [active]
743718005288	putative DNA binding site [nucleotide binding]; other site
743718005289	metal binding site [ion binding]; metal-binding site
743718005290	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743718005291	AsnC family; Region: AsnC_trans_reg; pfam01037
743718005292	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
743718005293	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
743718005294	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
743718005295	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
743718005296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718005297	active site
743718005298	phosphorylation site [posttranslational modification]
743718005299	intermolecular recognition site; other site
743718005300	dimerization interface [polypeptide binding]; other site
743718005301	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
743718005302	Subunit I/III interface [polypeptide binding]; other site
743718005303	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
743718005304	Cytochrome c; Region: Cytochrom_C; pfam00034
743718005305	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
743718005306	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
743718005307	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
743718005308	iron-sulfur cluster [ion binding]; other site
743718005309	[2Fe-2S] cluster binding site [ion binding]; other site
743718005310	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
743718005311	heme bH binding site [chemical binding]; other site
743718005312	intrachain domain interface; other site
743718005313	heme bL binding site [chemical binding]; other site
743718005314	interchain domain interface [polypeptide binding]; other site
743718005315	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
743718005316	Qo binding site; other site
743718005317	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
743718005318	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
743718005319	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
743718005320	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
743718005321	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
743718005322	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
743718005323	D-pathway; other site
743718005324	Putative ubiquinol binding site [chemical binding]; other site
743718005325	Low-spin heme (heme b) binding site [chemical binding]; other site
743718005326	Putative water exit pathway; other site
743718005327	Binuclear center (heme o3/CuB) [ion binding]; other site
743718005328	K-pathway; other site
743718005329	Putative proton exit pathway; other site
743718005330	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
743718005331	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
743718005332	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743718005333	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743718005334	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
743718005335	CPxP  motif; other site
743718005336	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
743718005337	quinolinate synthetase; Provisional; Region: PRK09375
743718005338	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
743718005339	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
743718005340	conserved cys residue [active]
743718005341	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743718005342	active site
743718005343	hypothetical protein; Provisional; Region: PRK07907
743718005344	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
743718005345	active site
743718005346	metal binding site [ion binding]; metal-binding site
743718005347	dimer interface [polypeptide binding]; other site
743718005348	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
743718005349	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718005350	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718005351	active site
743718005352	catalytic tetrad [active]
743718005353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718005354	Coenzyme A binding pocket [chemical binding]; other site
743718005355	arginine deiminase; Provisional; Region: PRK01388
743718005356	Predicted membrane protein [Function unknown]; Region: COG2364
743718005357	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743718005358	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718005359	DNA-binding site [nucleotide binding]; DNA binding site
743718005360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718005361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718005362	homodimer interface [polypeptide binding]; other site
743718005363	catalytic residue [active]
743718005364	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
743718005365	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
743718005366	quinone interaction residues [chemical binding]; other site
743718005367	active site
743718005368	catalytic residues [active]
743718005369	FMN binding site [chemical binding]; other site
743718005370	substrate binding site [chemical binding]; other site
743718005371	multifunctional aminopeptidase A; Provisional; Region: PRK00913
743718005372	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
743718005373	interface (dimer of trimers) [polypeptide binding]; other site
743718005374	Substrate-binding/catalytic site; other site
743718005375	Zn-binding sites [ion binding]; other site
743718005376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743718005377	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743718005378	E3 interaction surface; other site
743718005379	lipoyl attachment site [posttranslational modification]; other site
743718005380	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743718005381	E3 interaction surface; other site
743718005382	lipoyl attachment site [posttranslational modification]; other site
743718005383	e3 binding domain; Region: E3_binding; pfam02817
743718005384	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
743718005385	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743718005386	putative oxidoreductase; Provisional; Region: PRK11579
743718005387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718005388	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
743718005389	MMPL family; Region: MMPL; pfam03176
743718005390	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
743718005391	lipoyl synthase; Provisional; Region: PRK05481
743718005392	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743718005393	FeS/SAM binding site; other site
743718005394	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
743718005395	RDD family; Region: RDD; pfam06271
743718005396	glutamine synthetase, type I; Region: GlnA; TIGR00653
743718005397	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
743718005398	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
743718005399	Protein of unknown function (DUF808); Region: DUF808; cl01002
743718005400	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
743718005401	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
743718005402	metal binding triad; other site
743718005403	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
743718005404	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
743718005405	metal binding triad; other site
743718005406	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
743718005407	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
743718005408	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
743718005409	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
743718005410	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
743718005411	oligomerization interface [polypeptide binding]; other site
743718005412	active site
743718005413	metal binding site [ion binding]; metal-binding site
743718005414	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718005415	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743718005416	nucleotide binding site [chemical binding]; other site
743718005417	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718005418	anti sigma factor interaction site; other site
743718005419	regulatory phosphorylation site [posttranslational modification]; other site
743718005420	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
743718005421	elongation factor G; Reviewed; Region: PRK12740
743718005422	G1 box; other site
743718005423	GTP/Mg2+ binding site [chemical binding]; other site
743718005424	G2 box; other site
743718005425	Switch I region; other site
743718005426	G3 box; other site
743718005427	Switch II region; other site
743718005428	G4 box; other site
743718005429	G5 box; other site
743718005430	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
743718005431	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
743718005432	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
743718005433	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743718005434	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
743718005435	PemK-like protein; Region: PemK; pfam02452
743718005436	hypothetical protein; Validated; Region: PRK02101
743718005437	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
743718005438	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
743718005439	RNA/DNA hybrid binding site [nucleotide binding]; other site
743718005440	active site
743718005441	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718005442	catalytic core [active]
743718005443	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
743718005444	Putative zinc ribbon domain; Region: DUF164; pfam02591
743718005445	Uncharacterized conserved protein [Function unknown]; Region: COG0327
743718005446	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
743718005447	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
743718005448	FOG: CBS domain [General function prediction only]; Region: COG0517
743718005449	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
743718005450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005451	putative substrate translocation pore; other site
743718005452	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
743718005453	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
743718005454	active site
743718005455	DNA binding site [nucleotide binding]
743718005456	catalytic site [active]
743718005457	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743718005458	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718005459	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718005460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718005461	DNA binding residues [nucleotide binding]
743718005462	dimerization interface [polypeptide binding]; other site
743718005463	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743718005464	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
743718005465	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743718005466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718005467	DNA-binding site [nucleotide binding]; DNA binding site
743718005468	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718005469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718005470	homodimer interface [polypeptide binding]; other site
743718005471	catalytic residue [active]
743718005472	RibD C-terminal domain; Region: RibD_C; cl17279
743718005473	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
743718005474	Trehalose utilisation; Region: ThuA; pfam06283
743718005475	PhoD-like phosphatase; Region: PhoD; pfam09423
743718005476	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
743718005477	putative active site [active]
743718005478	putative metal binding site [ion binding]; other site
743718005479	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718005480	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718005481	DNA binding site [nucleotide binding]
743718005482	domain linker motif; other site
743718005483	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718005484	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743718005485	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743718005486	inhibitor site; inhibition site
743718005487	active site
743718005488	dimer interface [polypeptide binding]; other site
743718005489	catalytic residue [active]
743718005490	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
743718005491	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
743718005492	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
743718005493	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
743718005494	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
743718005495	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
743718005496	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718005497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718005498	dimer interface [polypeptide binding]; other site
743718005499	conserved gate region; other site
743718005500	ABC-ATPase subunit interface; other site
743718005501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743718005502	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743718005503	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718005504	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718005505	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
743718005506	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
743718005507	dimer interface [polypeptide binding]; other site
743718005508	catalytic triad [active]
743718005509	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
743718005510	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
743718005511	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
743718005512	dimer interface [polypeptide binding]; other site
743718005513	TPP-binding site [chemical binding]; other site
743718005514	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
743718005515	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
743718005516	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
743718005517	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743718005518	dimer interface [polypeptide binding]; other site
743718005519	active site
743718005520	CoA binding pocket [chemical binding]; other site
743718005521	acyl carrier protein; Provisional; Region: acpP; PRK00982
743718005522	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
743718005523	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
743718005524	dimer interface [polypeptide binding]; other site
743718005525	active site
743718005526	MG2 domain; Region: A2M_N; pfam01835
743718005527	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
743718005528	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
743718005529	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
743718005530	active site
743718005531	catalytic residues [active]
743718005532	metal binding site [ion binding]; metal-binding site
743718005533	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
743718005534	Transcriptional regulator [Transcription]; Region: IclR; COG1414
743718005535	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
743718005536	phenol 2-monooxygenase; Provisional; Region: PRK08294
743718005537	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
743718005538	dimer interface [polypeptide binding]; other site
743718005539	succinic semialdehyde dehydrogenase; Region: PLN02278
743718005540	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
743718005541	tetramerization interface [polypeptide binding]; other site
743718005542	NAD(P) binding site [chemical binding]; other site
743718005543	catalytic residues [active]
743718005544	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
743718005545	Domain of unknown function (DUF305); Region: DUF305; pfam03713
743718005546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005547	putative substrate translocation pore; other site
743718005548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005549	CHC2 zinc finger; Region: zf-CHC2; pfam01807
743718005550	DNA primase, catalytic core; Region: dnaG; TIGR01391
743718005551	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
743718005552	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
743718005553	active site
743718005554	metal binding site [ion binding]; metal-binding site
743718005555	interdomain interaction site; other site
743718005556	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
743718005557	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
743718005558	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743718005559	Zn2+ binding site [ion binding]; other site
743718005560	Mg2+ binding site [ion binding]; other site
743718005561	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
743718005562	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
743718005563	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
743718005564	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743718005565	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
743718005566	active site
743718005567	catalytic triad [active]
743718005568	oxyanion hole [active]
743718005569	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
743718005570	homodimer interface [polypeptide binding]; other site
743718005571	maltodextrin glucosidase; Provisional; Region: PRK10785
743718005572	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
743718005573	active site
743718005574	homodimer interface [polypeptide binding]; other site
743718005575	catalytic site [active]
743718005576	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718005577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718005578	dimer interface [polypeptide binding]; other site
743718005579	conserved gate region; other site
743718005580	putative PBP binding loops; other site
743718005581	ABC-ATPase subunit interface; other site
743718005582	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
743718005583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718005584	dimer interface [polypeptide binding]; other site
743718005585	conserved gate region; other site
743718005586	putative PBP binding loops; other site
743718005587	ABC-ATPase subunit interface; other site
743718005588	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743718005589	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718005590	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718005591	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718005592	DNA binding site [nucleotide binding]
743718005593	domain linker motif; other site
743718005594	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292
743718005595	putative dimerization interface [polypeptide binding]; other site
743718005596	putative ligand binding site [chemical binding]; other site
743718005597	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
743718005598	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
743718005599	active site
743718005600	catalytic site [active]
743718005601	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
743718005602	active site
743718005603	metal binding site [ion binding]; metal-binding site
743718005604	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
743718005605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743718005606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718005607	Coenzyme A binding pocket [chemical binding]; other site
743718005608	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
743718005609	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
743718005610	FMN binding site [chemical binding]; other site
743718005611	active site
743718005612	catalytic residues [active]
743718005613	substrate binding site [chemical binding]; other site
743718005614	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
743718005615	amino acid carrier protein; Region: agcS; TIGR00835
743718005616	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
743718005617	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
743718005618	tetrameric interface [polypeptide binding]; other site
743718005619	NAD binding site [chemical binding]; other site
743718005620	catalytic residues [active]
743718005621	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
743718005622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
743718005623	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
743718005624	hydroxyglutarate oxidase; Provisional; Region: PRK11728
743718005625	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718005626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718005627	dimerization interface [polypeptide binding]; other site
743718005628	glycyl-tRNA synthetase; Provisional; Region: PRK04173
743718005629	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
743718005630	dimer interface [polypeptide binding]; other site
743718005631	motif 1; other site
743718005632	active site
743718005633	motif 2; other site
743718005634	motif 3; other site
743718005635	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
743718005636	anticodon binding site; other site
743718005637	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743718005638	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
743718005639	intersubunit interface [polypeptide binding]; other site
743718005640	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
743718005641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718005642	Walker A/P-loop; other site
743718005643	ATP binding site [chemical binding]; other site
743718005644	Q-loop/lid; other site
743718005645	ABC transporter signature motif; other site
743718005646	Walker B; other site
743718005647	D-loop; other site
743718005648	H-loop/switch region; other site
743718005649	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
743718005650	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
743718005651	ABC-ATPase subunit  interface; other site
743718005652	dimer interface [polypeptide binding]; other site
743718005653	putative PBP binding regions; other site
743718005654	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
743718005655	metal binding site 2 [ion binding]; metal-binding site
743718005656	putative DNA binding helix; other site
743718005657	metal binding site 1 [ion binding]; metal-binding site
743718005658	dimer interface [polypeptide binding]; other site
743718005659	structural Zn2+ binding site [ion binding]; other site
743718005660	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743718005661	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
743718005662	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
743718005663	ABC-ATPase subunit  interface; other site
743718005664	dimer interface [polypeptide binding]; other site
743718005665	putative PBP binding regions; other site
743718005666	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
743718005667	ABC-ATPase subunit  interface; other site
743718005668	dimer interface [polypeptide binding]; other site
743718005669	putative PBP binding regions; other site
743718005670	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
743718005671	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
743718005672	Walker A/P-loop; other site
743718005673	ATP binding site [chemical binding]; other site
743718005674	Q-loop/lid; other site
743718005675	ABC transporter signature motif; other site
743718005676	Walker B; other site
743718005677	D-loop; other site
743718005678	H-loop/switch region; other site
743718005679	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
743718005680	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743718005681	intersubunit interface [polypeptide binding]; other site
743718005682	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
743718005683	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
743718005684	catalytic residue [active]
743718005685	putative FPP diphosphate  binding site; other site
743718005686	putative FPP binding hydrophobic cleft; other site
743718005687	dimer interface [polypeptide binding]; other site
743718005688	putative IPP diphosphate binding site; other site
743718005689	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
743718005690	Recombination protein O N terminal; Region: RecO_N; pfam11967
743718005691	Recombination protein O C terminal; Region: RecO_C; pfam02565
743718005692	2-isopropylmalate synthase; Validated; Region: PRK03739
743718005693	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
743718005694	active site
743718005695	catalytic residues [active]
743718005696	metal binding site [ion binding]; metal-binding site
743718005697	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
743718005698	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718005699	GTPase Era; Reviewed; Region: era; PRK00089
743718005700	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
743718005701	G1 box; other site
743718005702	GTP/Mg2+ binding site [chemical binding]; other site
743718005703	Switch I region; other site
743718005704	G2 box; other site
743718005705	Switch II region; other site
743718005706	G3 box; other site
743718005707	G4 box; other site
743718005708	G5 box; other site
743718005709	KH domain; Region: KH_2; pfam07650
743718005710	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718005711	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
743718005712	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718005713	Transporter associated domain; Region: CorC_HlyC; smart01091
743718005714	metal-binding heat shock protein; Provisional; Region: PRK00016
743718005715	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
743718005716	PhoH-like protein; Region: PhoH; pfam02562
743718005717	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
743718005718	nucleotide binding site/active site [active]
743718005719	HIT family signature motif; other site
743718005720	catalytic residue [active]
743718005721	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
743718005722	RNA methyltransferase, RsmE family; Region: TIGR00046
743718005723	chaperone protein DnaJ; Provisional; Region: PRK14278
743718005724	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
743718005725	HSP70 interaction site [polypeptide binding]; other site
743718005726	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
743718005727	Zn binding sites [ion binding]; other site
743718005728	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
743718005729	dimer interface [polypeptide binding]; other site
743718005730	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
743718005731	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
743718005732	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
743718005733	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
743718005734	Tic20-like protein; Region: Tic20; pfam09685
743718005735	coproporphyrinogen III oxidase; Validated; Region: PRK05628
743718005736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743718005737	FeS/SAM binding site; other site
743718005738	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743718005739	HemN C-terminal domain; Region: HemN_C; pfam06969
743718005740	GTP-binding protein LepA; Provisional; Region: PRK05433
743718005741	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
743718005742	G1 box; other site
743718005743	putative GEF interaction site [polypeptide binding]; other site
743718005744	GTP/Mg2+ binding site [chemical binding]; other site
743718005745	Switch I region; other site
743718005746	G2 box; other site
743718005747	G3 box; other site
743718005748	Switch II region; other site
743718005749	G4 box; other site
743718005750	G5 box; other site
743718005751	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
743718005752	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
743718005753	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
743718005754	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718005755	intracellular protease, PfpI family; Region: PfpI; TIGR01382
743718005756	conserved cys residue [active]
743718005757	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
743718005758	PemK-like protein; Region: PemK; pfam02452
743718005759	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
743718005760	hypothetical protein; Reviewed; Region: PRK07914
743718005761	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
743718005762	Competence protein; Region: Competence; pfam03772
743718005763	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
743718005764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743718005765	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
743718005766	EDD domain protein, DegV family; Region: DegV; TIGR00762
743718005767	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
743718005768	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
743718005769	homodimer interface [polypeptide binding]; other site
743718005770	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
743718005771	active site pocket [active]
743718005772	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
743718005773	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
743718005774	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
743718005775	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
743718005776	aminoacyl-tRNA ligase; Region: PLN02563
743718005777	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718005778	active site
743718005779	HIGH motif; other site
743718005780	nucleotide binding site [chemical binding]; other site
743718005781	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718005782	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
743718005783	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718005784	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718005785	active site
743718005786	KMSKS motif; other site
743718005787	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
743718005788	tRNA binding surface [nucleotide binding]; other site
743718005789	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743718005790	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
743718005791	putative active site [active]
743718005792	redox center [active]
743718005793	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
743718005794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005795	putative substrate translocation pore; other site
743718005796	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
743718005797	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
743718005798	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
743718005799	FeoA domain; Region: FeoA; pfam04023
743718005800	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743718005801	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
743718005802	active site
743718005803	metal binding site [ion binding]; metal-binding site
743718005804	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
743718005805	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
743718005806	putative DNA binding site [nucleotide binding]; other site
743718005807	putative homodimer interface [polypeptide binding]; other site
743718005808	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
743718005809	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
743718005810	trimer interface [polypeptide binding]; other site
743718005811	putative metal binding site [ion binding]; other site
743718005812	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
743718005813	catalytic residues [active]
743718005814	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
743718005815	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
743718005816	nucleotide binding site [chemical binding]; other site
743718005817	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
743718005818	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
743718005819	active site
743718005820	DNA binding site [nucleotide binding]
743718005821	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
743718005822	DNA binding site [nucleotide binding]
743718005823	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
743718005824	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
743718005825	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
743718005826	active site
743718005827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718005828	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743718005829	NAD(P) binding site [chemical binding]; other site
743718005830	active site
743718005831	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718005832	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718005833	active site
743718005834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718005835	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718005836	active site
743718005837	metal binding site [ion binding]; metal-binding site
743718005838	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
743718005839	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
743718005840	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718005841	Coenzyme A binding pocket [chemical binding]; other site
743718005842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718005843	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
743718005844	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
743718005845	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
743718005846	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
743718005847	malate:quinone oxidoreductase; Validated; Region: PRK05257
743718005848	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
743718005849	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
743718005850	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
743718005851	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
743718005852	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
743718005853	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
743718005854	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
743718005855	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
743718005856	ligand binding site [chemical binding]; other site
743718005857	homodimer interface [polypeptide binding]; other site
743718005858	NAD(P) binding site [chemical binding]; other site
743718005859	trimer interface B [polypeptide binding]; other site
743718005860	trimer interface A [polypeptide binding]; other site
743718005861	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
743718005862	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
743718005863	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
743718005864	active site
743718005865	catalytic site [active]
743718005866	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
743718005867	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
743718005868	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
743718005869	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
743718005870	catalytic site [active]
743718005871	active site
743718005872	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
743718005873	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
743718005874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718005875	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
743718005876	mannonate dehydratase; Provisional; Region: PRK03906
743718005877	mannonate dehydratase; Region: uxuA; TIGR00695
743718005878	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
743718005879	putative hydrophobic ligand binding site [chemical binding]; other site
743718005880	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
743718005881	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
743718005882	Beta-lactamase; Region: Beta-lactamase; pfam00144
743718005883	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743718005884	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743718005885	anti sigma factor interaction site; other site
743718005886	regulatory phosphorylation site [posttranslational modification]; other site
743718005887	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
743718005888	hypothetical protein; Provisional; Region: PRK07236
743718005889	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743718005890	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743718005891	Integrase core domain; Region: rve; pfam00665
743718005892	Integrase core domain; Region: rve_3; cl15866
743718005893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
743718005894	Transposase; Region: HTH_Tnp_1; cl17663
743718005895	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
743718005896	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743718005897	MarR family; Region: MarR_2; cl17246
743718005898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743718005899	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743718005900	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718005901	catalytic core [active]
743718005902	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
743718005903	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
743718005904	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
743718005905	active site
743718005906	(T/H)XGH motif; other site
743718005907	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
743718005908	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
743718005909	putative catalytic cysteine [active]
743718005910	benzoate transport; Region: 2A0115; TIGR00895
743718005911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005912	putative substrate translocation pore; other site
743718005913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718005914	gamma-glutamyl kinase; Provisional; Region: PRK05429
743718005915	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
743718005916	nucleotide binding site [chemical binding]; other site
743718005917	homotetrameric interface [polypeptide binding]; other site
743718005918	putative phosphate binding site [ion binding]; other site
743718005919	putative allosteric binding site; other site
743718005920	PUA domain; Region: PUA; pfam01472
743718005921	GTPase CgtA; Reviewed; Region: obgE; PRK12296
743718005922	GTP1/OBG; Region: GTP1_OBG; pfam01018
743718005923	Obg GTPase; Region: Obg; cd01898
743718005924	G1 box; other site
743718005925	GTP/Mg2+ binding site [chemical binding]; other site
743718005926	Switch I region; other site
743718005927	G2 box; other site
743718005928	G3 box; other site
743718005929	Switch II region; other site
743718005930	G4 box; other site
743718005931	G5 box; other site
743718005932	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
743718005933	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
743718005934	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
743718005935	BCCT family transporter; Region: BCCT; pfam02028
743718005936	Dodecin; Region: Dodecin; pfam07311
743718005937	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
743718005938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718005939	S-adenosylmethionine binding site [chemical binding]; other site
743718005940	Fatty acid desaturase; Region: FA_desaturase; pfam00487
743718005941	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
743718005942	putative di-iron ligands [ion binding]; other site
743718005943	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
743718005944	thymidine kinase; Provisional; Region: PRK04296
743718005945	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
743718005946	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
743718005947	homodimer interface [polypeptide binding]; other site
743718005948	oligonucleotide binding site [chemical binding]; other site
743718005949	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
743718005950	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
743718005951	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
743718005952	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
743718005953	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
743718005954	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743718005955	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
743718005956	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
743718005957	Walker A/P-loop; other site
743718005958	ATP binding site [chemical binding]; other site
743718005959	Q-loop/lid; other site
743718005960	ABC transporter signature motif; other site
743718005961	Walker B; other site
743718005962	D-loop; other site
743718005963	H-loop/switch region; other site
743718005964	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
743718005965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718005966	Q-loop/lid; other site
743718005967	ABC transporter signature motif; other site
743718005968	Walker B; other site
743718005969	D-loop; other site
743718005970	H-loop/switch region; other site
743718005971	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
743718005972	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
743718005973	putative active site [active]
743718005974	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
743718005975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743718005976	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
743718005977	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160
743718005978	putative ligand binding site [chemical binding]; other site
743718005979	putative NAD binding site [chemical binding]; other site
743718005980	catalytic site [active]
743718005981	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
743718005982	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
743718005983	DNA binding site [nucleotide binding]
743718005984	catalytic residue [active]
743718005985	H2TH interface [polypeptide binding]; other site
743718005986	putative catalytic residues [active]
743718005987	turnover-facilitating residue; other site
743718005988	intercalation triad [nucleotide binding]; other site
743718005989	8OG recognition residue [nucleotide binding]; other site
743718005990	putative reading head residues; other site
743718005991	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
743718005992	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
743718005993	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
743718005994	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
743718005995	dimerization interface [polypeptide binding]; other site
743718005996	active site
743718005997	metal binding site [ion binding]; metal-binding site
743718005998	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
743718005999	dsRNA binding site [nucleotide binding]; other site
743718006000	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
743718006001	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
743718006002	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
743718006003	pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510
743718006004	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718006005	active site
743718006006	nucleotide binding site [chemical binding]; other site
743718006007	HIGH motif; other site
743718006008	KMSKS motif; other site
743718006009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743718006010	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
743718006011	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
743718006012	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
743718006013	ssDNA binding site; other site
743718006014	generic binding surface II; other site
743718006015	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718006016	ATP binding site [chemical binding]; other site
743718006017	putative Mg++ binding site [ion binding]; other site
743718006018	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718006019	nucleotide binding region [chemical binding]; other site
743718006020	ATP-binding site [chemical binding]; other site
743718006021	DAK2 domain; Region: Dak2; cl03685
743718006022	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
743718006023	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743718006024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718006025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718006026	Coenzyme A binding pocket [chemical binding]; other site
743718006027	thiamine monophosphate kinase; Provisional; Region: PRK05731
743718006028	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
743718006029	ATP binding site [chemical binding]; other site
743718006030	dimerization interface [polypeptide binding]; other site
743718006031	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
743718006032	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718006033	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
743718006034	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
743718006035	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
743718006036	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
743718006037	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743718006038	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
743718006039	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
743718006040	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
743718006041	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743718006042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718006043	catalytic residue [active]
743718006044	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
743718006045	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
743718006046	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
743718006047	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743718006048	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
743718006049	putative acyl-acceptor binding pocket; other site
743718006050	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
743718006051	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
743718006052	hinge; other site
743718006053	active site
743718006054	metabolite-proton symporter; Region: 2A0106; TIGR00883
743718006055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718006056	putative substrate translocation pore; other site
743718006057	Nuclease-related domain; Region: NERD; pfam08378
743718006058	oxidoreductase; Provisional; Region: PRK06128
743718006059	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
743718006060	NAD binding site [chemical binding]; other site
743718006061	metal binding site [ion binding]; metal-binding site
743718006062	active site
743718006063	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
743718006064	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743718006065	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
743718006066	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718006067	putative substrate binding site [chemical binding]; other site
743718006068	putative ATP binding site [chemical binding]; other site
743718006069	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
743718006070	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
743718006071	substrate binding [chemical binding]; other site
743718006072	active site
743718006073	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743718006074	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
743718006075	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
743718006076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718006077	Walker A/P-loop; other site
743718006078	ATP binding site [chemical binding]; other site
743718006079	Q-loop/lid; other site
743718006080	ABC transporter signature motif; other site
743718006081	Walker B; other site
743718006082	D-loop; other site
743718006083	H-loop/switch region; other site
743718006084	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718006085	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718006086	TM-ABC transporter signature motif; other site
743718006087	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
743718006088	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
743718006089	ligand binding site [chemical binding]; other site
743718006090	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718006091	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718006092	DNA binding site [nucleotide binding]
743718006093	domain linker motif; other site
743718006094	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718006095	dimerization interface [polypeptide binding]; other site
743718006096	ligand binding site [chemical binding]; other site
743718006097	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743718006098	intermolecular salt bridges; other site
743718006099	calcium mediated ligand binding site; other site
743718006100	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
743718006101	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
743718006102	substrate binding [chemical binding]; other site
743718006103	active site
743718006104	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
743718006105	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743718006106	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
743718006107	putative substrate binding site [chemical binding]; other site
743718006108	putative ATP binding site [chemical binding]; other site
743718006109	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
743718006110	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
743718006111	substrate binding [chemical binding]; other site
743718006112	active site
743718006113	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
743718006114	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718006115	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718006116	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718006117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006118	dimer interface [polypeptide binding]; other site
743718006119	conserved gate region; other site
743718006120	putative PBP binding loops; other site
743718006121	ABC-ATPase subunit interface; other site
743718006122	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718006123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718006124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006125	dimer interface [polypeptide binding]; other site
743718006126	ABC-ATPase subunit interface; other site
743718006127	putative PBP binding loops; other site
743718006128	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718006129	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718006130	DNA binding site [nucleotide binding]
743718006131	domain linker motif; other site
743718006132	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
743718006133	putative dimerization interface [polypeptide binding]; other site
743718006134	putative ligand binding site [chemical binding]; other site
743718006135	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743718006136	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
743718006137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718006138	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
743718006139	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743718006140	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718006141	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
743718006142	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
743718006143	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
743718006144	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
743718006145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718006146	S-adenosylmethionine binding site [chemical binding]; other site
743718006147	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
743718006148	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
743718006149	substrate binding site [chemical binding]; other site
743718006150	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
743718006151	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
743718006152	substrate binding site [chemical binding]; other site
743718006153	ligand binding site [chemical binding]; other site
743718006154	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
743718006155	Transcriptional regulator [Transcription]; Region: IclR; COG1414
743718006156	Bacterial transcriptional regulator; Region: IclR; pfam01614
743718006157	Bacterial PH domain; Region: DUF304; pfam03703
743718006158	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
743718006159	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718006160	motif II; other site
743718006161	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
743718006162	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718006163	active site
743718006164	HIGH motif; other site
743718006165	nucleotide binding site [chemical binding]; other site
743718006166	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
743718006167	active site
743718006168	KMSKS motif; other site
743718006169	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
743718006170	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
743718006171	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
743718006172	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743718006173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718006174	S-adenosylmethionine binding site [chemical binding]; other site
743718006175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
743718006176	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
743718006177	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
743718006178	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718006179	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718006180	active site
743718006181	catalytic tetrad [active]
743718006182	CGNR zinc finger; Region: zf-CGNR; pfam11706
743718006183	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
743718006184	DEAD-like helicases superfamily; Region: DEXDc; smart00487
743718006185	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718006186	ATP binding site [chemical binding]; other site
743718006187	putative Mg++ binding site [ion binding]; other site
743718006188	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718006189	nucleotide binding region [chemical binding]; other site
743718006190	ATP-binding site [chemical binding]; other site
743718006191	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
743718006192	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
743718006193	putative deacylase active site [active]
743718006194	hypothetical protein; Provisional; Region: PRK11770
743718006195	Domain of unknown function (DUF307); Region: DUF307; pfam03733
743718006196	Domain of unknown function (DUF307); Region: DUF307; pfam03733
743718006197	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
743718006198	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743718006199	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
743718006200	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
743718006201	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
743718006202	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
743718006203	putative active site [active]
743718006204	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
743718006205	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
743718006206	active site
743718006207	catalytic residues [active]
743718006208	metal binding site [ion binding]; metal-binding site
743718006209	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
743718006210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718006211	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718006212	DNA binding residues [nucleotide binding]
743718006213	dimerization interface [polypeptide binding]; other site
743718006214	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
743718006215	UbiA prenyltransferase family; Region: UbiA; pfam01040
743718006216	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
743718006217	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718006218	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
743718006219	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
743718006220	TatD related DNase; Region: TatD_DNase; pfam01026
743718006221	active site
743718006222	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718006223	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743718006224	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
743718006225	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
743718006226	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
743718006227	homodimer interface [polypeptide binding]; other site
743718006228	substrate-cofactor binding pocket; other site
743718006229	catalytic residue [active]
743718006230	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
743718006231	tartrate dehydrogenase; Region: TTC; TIGR02089
743718006232	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
743718006233	active site
743718006234	metal binding site [ion binding]; metal-binding site
743718006235	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718006236	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
743718006237	ketol-acid reductoisomerase; Provisional; Region: PRK05479
743718006238	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
743718006239	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
743718006240	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
743718006241	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
743718006242	putative valine binding site [chemical binding]; other site
743718006243	dimer interface [polypeptide binding]; other site
743718006244	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
743718006245	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
743718006246	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
743718006247	PYR/PP interface [polypeptide binding]; other site
743718006248	dimer interface [polypeptide binding]; other site
743718006249	TPP binding site [chemical binding]; other site
743718006250	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
743718006251	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
743718006252	TPP-binding site [chemical binding]; other site
743718006253	dimer interface [polypeptide binding]; other site
743718006254	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718006255	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718006256	Walker A/P-loop; other site
743718006257	ATP binding site [chemical binding]; other site
743718006258	Q-loop/lid; other site
743718006259	ABC transporter signature motif; other site
743718006260	Walker B; other site
743718006261	D-loop; other site
743718006262	H-loop/switch region; other site
743718006263	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
743718006264	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
743718006265	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
743718006266	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718006267	Coenzyme A binding pocket [chemical binding]; other site
743718006268	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
743718006269	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
743718006270	GatB domain; Region: GatB_Yqey; smart00845
743718006271	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
743718006272	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
743718006273	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
743718006274	Trehalose utilisation; Region: ThuA; pfam06283
743718006275	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718006276	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718006277	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
743718006278	metal binding site [ion binding]; metal-binding site
743718006279	ligand binding site [chemical binding]; other site
743718006280	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743718006281	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
743718006282	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718006283	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718006284	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718006285	TM-ABC transporter signature motif; other site
743718006286	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718006287	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718006288	TM-ABC transporter signature motif; other site
743718006289	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
743718006290	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718006291	Walker A/P-loop; other site
743718006292	ATP binding site [chemical binding]; other site
743718006293	Q-loop/lid; other site
743718006294	ABC transporter signature motif; other site
743718006295	Walker B; other site
743718006296	D-loop; other site
743718006297	H-loop/switch region; other site
743718006298	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743718006299	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718006300	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743718006301	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
743718006302	Metal-binding active site; metal-binding site
743718006303	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
743718006304	Trehalose utilisation; Region: ThuA; pfam06283
743718006305	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718006306	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
743718006307	FOG: PKD repeat [General function prediction only]; Region: COG3291
743718006308	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718006309	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
743718006310	PKD domain; Region: PKD; pfam00801
743718006311	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
743718006312	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
743718006313	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718006314	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718006315	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743718006316	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
743718006317	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718006318	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718006319	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743718006320	TM-ABC transporter signature motif; other site
743718006321	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
743718006322	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743718006323	Walker A/P-loop; other site
743718006324	ATP binding site [chemical binding]; other site
743718006325	Q-loop/lid; other site
743718006326	ABC transporter signature motif; other site
743718006327	Walker B; other site
743718006328	D-loop; other site
743718006329	H-loop/switch region; other site
743718006330	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743718006331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
743718006332	putative DNA binding site [nucleotide binding]; other site
743718006333	putative Zn2+ binding site [ion binding]; other site
743718006334	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718006335	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743718006336	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718006337	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
743718006338	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
743718006339	nucleotide binding pocket [chemical binding]; other site
743718006340	K-X-D-G motif; other site
743718006341	catalytic site [active]
743718006342	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
743718006343	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
743718006344	Helix-hairpin-helix motif; Region: HHH; pfam00633
743718006345	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
743718006346	Dimer interface [polypeptide binding]; other site
743718006347	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
743718006348	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718006349	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
743718006350	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
743718006351	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
743718006352	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
743718006353	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
743718006354	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
743718006355	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
743718006356	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
743718006357	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
743718006358	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
743718006359	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
743718006360	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718006361	catalytic residue [active]
743718006362	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
743718006363	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
743718006364	MPT binding site; other site
743718006365	trimer interface [polypeptide binding]; other site
743718006366	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
743718006367	MoaE homodimer interface [polypeptide binding]; other site
743718006368	MoaD interaction [polypeptide binding]; other site
743718006369	active site residues [active]
743718006370	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
743718006371	trimer interface [polypeptide binding]; other site
743718006372	dimer interface [polypeptide binding]; other site
743718006373	putative active site [active]
743718006374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718006375	Walker A/P-loop; other site
743718006376	ATP binding site [chemical binding]; other site
743718006377	Q-loop/lid; other site
743718006378	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
743718006379	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
743718006380	dimer interface [polypeptide binding]; other site
743718006381	putative functional site; other site
743718006382	putative MPT binding site; other site
743718006383	sulfate transport protein; Provisional; Region: cysT; CHL00187
743718006384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
743718006385	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
743718006386	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
743718006387	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
743718006388	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
743718006389	active site
743718006390	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718006391	DNA binding site [nucleotide binding]
743718006392	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
743718006393	active site
743718006394	SAM binding site [chemical binding]; other site
743718006395	homodimer interface [polypeptide binding]; other site
743718006396	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
743718006397	nitrite reductase subunit NirD; Provisional; Region: PRK14989
743718006398	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
743718006399	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743718006400	AAA domain; Region: AAA_33; pfam13671
743718006401	AAA domain; Region: AAA_17; pfam13207
743718006402	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
743718006403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718006404	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
743718006405	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
743718006406	[4Fe-4S] binding site [ion binding]; other site
743718006407	molybdopterin cofactor binding site; other site
743718006408	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
743718006409	molybdopterin cofactor binding site; other site
743718006410	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
743718006411	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
743718006412	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
743718006413	dimer interface [polypeptide binding]; other site
743718006414	putative functional site; other site
743718006415	putative MPT binding site; other site
743718006416	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718006417	active site
743718006418	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
743718006419	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743718006420	FeS/SAM binding site; other site
743718006421	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
743718006422	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
743718006423	MoaE interaction surface [polypeptide binding]; other site
743718006424	MoeB interaction surface [polypeptide binding]; other site
743718006425	thiocarboxylated glycine; other site
743718006426	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
743718006427	ATP binding site [chemical binding]; other site
743718006428	substrate interface [chemical binding]; other site
743718006429	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743718006430	active site residue [active]
743718006431	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
743718006432	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743718006433	Ligand Binding Site [chemical binding]; other site
743718006434	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
743718006435	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
743718006436	Ligand binding site [chemical binding]; other site
743718006437	Electron transfer flavoprotein domain; Region: ETF; pfam01012
743718006438	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
743718006439	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
743718006440	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
743718006441	active site
743718006442	catalytic site [active]
743718006443	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743718006444	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
743718006445	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
743718006446	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
743718006447	active site
743718006448	homodimer interface [polypeptide binding]; other site
743718006449	catalytic site [active]
743718006450	acceptor binding site [chemical binding]; other site
743718006451	trehalose synthase; Region: treS_nterm; TIGR02456
743718006452	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
743718006453	active site
743718006454	catalytic site [active]
743718006455	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
743718006456	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
743718006457	glycogen branching enzyme; Provisional; Region: PRK05402
743718006458	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
743718006459	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
743718006460	active site
743718006461	catalytic site [active]
743718006462	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
743718006463	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
743718006464	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
743718006465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743718006466	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
743718006467	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718006468	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
743718006469	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
743718006470	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743718006471	haloalkane dehalogenase; Provisional; Region: PRK00870
743718006472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
743718006473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718006474	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743718006475	classical (c) SDRs; Region: SDR_c; cd05233
743718006476	NAD(P) binding site [chemical binding]; other site
743718006477	active site
743718006478	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718006479	dimerization interface [polypeptide binding]; other site
743718006480	putative DNA binding site [nucleotide binding]; other site
743718006481	putative Zn2+ binding site [ion binding]; other site
743718006482	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
743718006483	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
743718006484	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
743718006485	heterotetramer interface [polypeptide binding]; other site
743718006486	active site pocket [active]
743718006487	cleavage site
743718006488	UreD urease accessory protein; Region: UreD; cl00530
743718006489	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743718006490	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
743718006491	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
743718006492	alpha-beta subunit interface [polypeptide binding]; other site
743718006493	urease subunit alpha; Reviewed; Region: ureC; PRK13206
743718006494	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
743718006495	subunit interactions [polypeptide binding]; other site
743718006496	active site
743718006497	flap region; other site
743718006498	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
743718006499	alpha-gamma subunit interface [polypeptide binding]; other site
743718006500	beta-gamma subunit interface [polypeptide binding]; other site
743718006501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718006502	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
743718006503	Walker A/P-loop; other site
743718006504	ATP binding site [chemical binding]; other site
743718006505	Q-loop/lid; other site
743718006506	ABC transporter signature motif; other site
743718006507	Walker B; other site
743718006508	D-loop; other site
743718006509	H-loop/switch region; other site
743718006510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718006511	Walker A/P-loop; other site
743718006512	ATP binding site [chemical binding]; other site
743718006513	Q-loop/lid; other site
743718006514	ABC transporter signature motif; other site
743718006515	Walker B; other site
743718006516	D-loop; other site
743718006517	H-loop/switch region; other site
743718006518	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
743718006519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006520	dimer interface [polypeptide binding]; other site
743718006521	conserved gate region; other site
743718006522	putative PBP binding loops; other site
743718006523	ABC-ATPase subunit interface; other site
743718006524	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
743718006525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006526	dimer interface [polypeptide binding]; other site
743718006527	conserved gate region; other site
743718006528	putative PBP binding loops; other site
743718006529	ABC-ATPase subunit interface; other site
743718006530	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
743718006531	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
743718006532	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
743718006533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006534	dimer interface [polypeptide binding]; other site
743718006535	conserved gate region; other site
743718006536	putative PBP binding loops; other site
743718006537	ABC-ATPase subunit interface; other site
743718006538	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
743718006539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006540	dimer interface [polypeptide binding]; other site
743718006541	conserved gate region; other site
743718006542	putative PBP binding loops; other site
743718006543	ABC-ATPase subunit interface; other site
743718006544	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718006545	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
743718006546	Walker A/P-loop; other site
743718006547	ATP binding site [chemical binding]; other site
743718006548	Q-loop/lid; other site
743718006549	ABC transporter signature motif; other site
743718006550	Walker B; other site
743718006551	D-loop; other site
743718006552	H-loop/switch region; other site
743718006553	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
743718006554	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
743718006555	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718006556	Walker A/P-loop; other site
743718006557	ATP binding site [chemical binding]; other site
743718006558	Q-loop/lid; other site
743718006559	ABC transporter signature motif; other site
743718006560	Walker B; other site
743718006561	D-loop; other site
743718006562	H-loop/switch region; other site
743718006563	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718006564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718006565	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743718006566	putative substrate translocation pore; other site
743718006567	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
743718006568	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
743718006569	agmatinase; Region: agmatinase; TIGR01230
743718006570	Agmatinase-like family; Region: Agmatinase-like; cd09990
743718006571	active site
743718006572	oligomer interface [polypeptide binding]; other site
743718006573	Mn binding site [ion binding]; other site
743718006574	agmatinase; Region: agmatinase; TIGR01230
743718006575	Agmatinase-like family; Region: Agmatinase-like; cd09990
743718006576	active site
743718006577	oligomer interface [polypeptide binding]; other site
743718006578	Mn binding site [ion binding]; other site
743718006579	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
743718006580	Ligand-binding domain of the LacI-GalR family of transcription regulators and the sugar-binding domain of ABC-type transport systems; Region: PBP1_Repressors_Sugar_Binding_like; cd01537
743718006581	ligand binding site; other site
743718006582	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743718006583	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743718006584	inhibitor site; inhibition site
743718006585	active site
743718006586	dimer interface [polypeptide binding]; other site
743718006587	catalytic residue [active]
743718006588	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743718006589	Nuclease-related domain; Region: NERD; pfam08378
743718006590	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
743718006591	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
743718006592	dimer interface [polypeptide binding]; other site
743718006593	putative radical transfer pathway; other site
743718006594	diiron center [ion binding]; other site
743718006595	tyrosyl radical; other site
743718006596	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
743718006597	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
743718006598	Class I ribonucleotide reductase; Region: RNR_I; cd01679
743718006599	active site
743718006600	dimer interface [polypeptide binding]; other site
743718006601	catalytic residues [active]
743718006602	effector binding site; other site
743718006603	R2 peptide binding site; other site
743718006604	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
743718006605	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
743718006606	catalytic residues [active]
743718006607	Beta-lactamase; Region: Beta-lactamase; pfam00144
743718006608	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743718006609	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
743718006610	beta-galactosidase; Region: BGL; TIGR03356
743718006611	putative alpha-glucosidase; Provisional; Region: PRK10658
743718006612	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
743718006613	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
743718006614	active site
743718006615	homotrimer interface [polypeptide binding]; other site
743718006616	catalytic site [active]
743718006617	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
743718006618	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
743718006619	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
743718006620	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743718006621	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
743718006622	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718006623	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718006624	DNA binding site [nucleotide binding]
743718006625	domain linker motif; other site
743718006626	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718006627	dimerization interface [polypeptide binding]; other site
743718006628	ligand binding site [chemical binding]; other site
743718006629	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718006630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006631	dimer interface [polypeptide binding]; other site
743718006632	conserved gate region; other site
743718006633	putative PBP binding loops; other site
743718006634	ABC-ATPase subunit interface; other site
743718006635	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718006636	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006637	dimer interface [polypeptide binding]; other site
743718006638	conserved gate region; other site
743718006639	ABC-ATPase subunit interface; other site
743718006640	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718006641	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
743718006642	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743718006643	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
743718006644	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
743718006645	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743718006646	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
743718006647	active site
743718006648	hypothetical protein; Provisional; Region: PRK03298
743718006649	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
743718006650	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
743718006651	gamma subunit interface [polypeptide binding]; other site
743718006652	epsilon subunit interface [polypeptide binding]; other site
743718006653	LBP interface [polypeptide binding]; other site
743718006654	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
743718006655	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
743718006656	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
743718006657	alpha subunit interaction interface [polypeptide binding]; other site
743718006658	Walker A motif; other site
743718006659	ATP binding site [chemical binding]; other site
743718006660	Walker B motif; other site
743718006661	inhibitor binding site; inhibition site
743718006662	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
743718006663	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
743718006664	core domain interface [polypeptide binding]; other site
743718006665	delta subunit interface [polypeptide binding]; other site
743718006666	epsilon subunit interface [polypeptide binding]; other site
743718006667	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
743718006668	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
743718006669	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
743718006670	beta subunit interaction interface [polypeptide binding]; other site
743718006671	Walker A motif; other site
743718006672	ATP binding site [chemical binding]; other site
743718006673	Walker B motif; other site
743718006674	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
743718006675	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
743718006676	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
743718006677	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
743718006678	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
743718006679	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
743718006680	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
743718006681	Mg++ binding site [ion binding]; other site
743718006682	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
743718006683	putative catalytic motif [active]
743718006684	substrate binding site [chemical binding]; other site
743718006685	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
743718006686	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
743718006687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718006688	S-adenosylmethionine binding site [chemical binding]; other site
743718006689	peptide chain release factor 1; Validated; Region: prfA; PRK00591
743718006690	This domain is found in peptide chain release factors; Region: PCRF; smart00937
743718006691	RF-1 domain; Region: RF-1; pfam00472
743718006692	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
743718006693	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
743718006694	transcription termination factor Rho; Provisional; Region: PRK12608
743718006695	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743718006696	RNA binding site [nucleotide binding]; other site
743718006697	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
743718006698	multimer interface [polypeptide binding]; other site
743718006699	Walker A motif; other site
743718006700	ATP binding site [chemical binding]; other site
743718006701	Walker B motif; other site
743718006702	homoserine kinase; Provisional; Region: PRK01212
743718006703	threonine synthase; Reviewed; Region: PRK06721
743718006704	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
743718006705	homodimer interface [polypeptide binding]; other site
743718006706	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718006707	catalytic residue [active]
743718006708	homoserine dehydrogenase; Provisional; Region: PRK06349
743718006709	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
743718006710	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
743718006711	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
743718006712	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
743718006713	Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489
743718006714	active site
743718006715	catalytic triad [active]
743718006716	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
743718006717	PA/protease or protease-like domain interface [polypeptide binding]; other site
743718006718	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
743718006719	catalytic residues [active]
743718006720	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
743718006721	diaminopimelate decarboxylase; Region: lysA; TIGR01048
743718006722	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
743718006723	active site
743718006724	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743718006725	substrate binding site [chemical binding]; other site
743718006726	catalytic residues [active]
743718006727	dimer interface [polypeptide binding]; other site
743718006728	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
743718006729	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
743718006730	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
743718006731	active site
743718006732	HIGH motif; other site
743718006733	KMSK motif region; other site
743718006734	tRNA binding surface [nucleotide binding]; other site
743718006735	DALR anticodon binding domain; Region: DALR_1; smart00836
743718006736	anticodon binding site; other site
743718006737	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
743718006738	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
743718006739	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
743718006740	tetramer interface [polypeptide binding]; other site
743718006741	active site
743718006742	Mg2+/Mn2+ binding site [ion binding]; other site
743718006743	citrate synthase; Provisional; Region: PRK14033
743718006744	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
743718006745	oxalacetate binding site [chemical binding]; other site
743718006746	citrylCoA binding site [chemical binding]; other site
743718006747	coenzyme A binding site [chemical binding]; other site
743718006748	catalytic triad [active]
743718006749	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
743718006750	putative active site [active]
743718006751	putative metal binding residues [ion binding]; other site
743718006752	signature motif; other site
743718006753	putative dimer interface [polypeptide binding]; other site
743718006754	putative phosphate binding site [ion binding]; other site
743718006755	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
743718006756	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
743718006757	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718006758	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718006759	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
743718006760	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718006761	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718006762	Transporter associated domain; Region: CorC_HlyC; smart01091
743718006763	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718006764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718006765	active site
743718006766	phosphorylation site [posttranslational modification]
743718006767	intermolecular recognition site; other site
743718006768	dimerization interface [polypeptide binding]; other site
743718006769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718006770	DNA binding site [nucleotide binding]
743718006771	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718006772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743718006773	dimerization interface [polypeptide binding]; other site
743718006774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718006775	dimer interface [polypeptide binding]; other site
743718006776	phosphorylation site [posttranslational modification]
743718006777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718006778	ATP binding site [chemical binding]; other site
743718006779	Mg2+ binding site [ion binding]; other site
743718006780	G-X-G motif; other site
743718006781	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
743718006782	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743718006783	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
743718006784	TPP-binding site [chemical binding]; other site
743718006785	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
743718006786	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718006787	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718006788	active site
743718006789	catalytic tetrad [active]
743718006790	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
743718006791	active site
743718006792	catalytic residues [active]
743718006793	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743718006794	active site
743718006795	catalytic triad [active]
743718006796	oxyanion hole [active]
743718006797	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
743718006798	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
743718006799	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718006800	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718006801	DNA binding residues [nucleotide binding]
743718006802	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
743718006803	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
743718006804	hinge; other site
743718006805	active site
743718006806	Predicted GTPases [General function prediction only]; Region: COG1162
743718006807	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
743718006808	GTPase/Zn-binding domain interface [polypeptide binding]; other site
743718006809	GTP/Mg2+ binding site [chemical binding]; other site
743718006810	G4 box; other site
743718006811	G5 box; other site
743718006812	G1 box; other site
743718006813	Switch I region; other site
743718006814	G2 box; other site
743718006815	G3 box; other site
743718006816	Switch II region; other site
743718006817	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
743718006818	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
743718006819	active site
743718006820	Helix-turn-helix domain; Region: HTH_17; pfam12728
743718006821	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743718006822	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
743718006823	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
743718006824	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
743718006825	nucleotide binding region [chemical binding]; other site
743718006826	SEC-C motif; Region: SEC-C; pfam02810
743718006827	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
743718006828	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
743718006829	TrkA-N domain; Region: TrkA_N; pfam02254
743718006830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
743718006831	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
743718006832	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
743718006833	30S subunit binding site; other site
743718006834	lipoprotein LpqB; Provisional; Region: PRK13615
743718006835	Sporulation and spore germination; Region: Germane; pfam10646
743718006836	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
743718006837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
743718006838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718006839	dimerization interface [polypeptide binding]; other site
743718006840	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718006841	dimer interface [polypeptide binding]; other site
743718006842	phosphorylation site [posttranslational modification]
743718006843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718006844	ATP binding site [chemical binding]; other site
743718006845	Mg2+ binding site [ion binding]; other site
743718006846	G-X-G motif; other site
743718006847	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718006848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718006849	active site
743718006850	phosphorylation site [posttranslational modification]
743718006851	intermolecular recognition site; other site
743718006852	dimerization interface [polypeptide binding]; other site
743718006853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718006854	DNA binding site [nucleotide binding]
743718006855	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
743718006856	Protein of unknown function DUF58; Region: DUF58; pfam01882
743718006857	Integral membrane protein DUF95; Region: DUF95; pfam01944
743718006858	RDD family; Region: RDD; pfam06271
743718006859	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743718006860	active site
743718006861	Zn binding site [ion binding]; other site
743718006862	Adenosylhomocysteinase; Provisional; Region: PTZ00075
743718006863	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
743718006864	homotetramer interface [polypeptide binding]; other site
743718006865	ligand binding site [chemical binding]; other site
743718006866	catalytic site [active]
743718006867	NAD binding site [chemical binding]; other site
743718006868	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743718006869	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743718006870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718006871	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
743718006872	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
743718006873	Walker A/P-loop; other site
743718006874	ATP binding site [chemical binding]; other site
743718006875	Q-loop/lid; other site
743718006876	ABC transporter signature motif; other site
743718006877	Walker B; other site
743718006878	D-loop; other site
743718006879	H-loop/switch region; other site
743718006880	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
743718006881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718006882	dimer interface [polypeptide binding]; other site
743718006883	conserved gate region; other site
743718006884	putative PBP binding loops; other site
743718006885	ABC-ATPase subunit interface; other site
743718006886	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
743718006887	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
743718006888	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
743718006889	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
743718006890	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
743718006891	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743718006892	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
743718006893	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
743718006894	CysD dimerization site [polypeptide binding]; other site
743718006895	G1 box; other site
743718006896	putative GEF interaction site [polypeptide binding]; other site
743718006897	GTP/Mg2+ binding site [chemical binding]; other site
743718006898	Switch I region; other site
743718006899	G2 box; other site
743718006900	G3 box; other site
743718006901	Switch II region; other site
743718006902	G4 box; other site
743718006903	G5 box; other site
743718006904	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
743718006905	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
743718006906	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
743718006907	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
743718006908	Active Sites [active]
743718006909	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
743718006910	active site
743718006911	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743718006912	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
743718006913	AAA domain; Region: AAA_18; pfam13238
743718006914	ligand-binding site [chemical binding]; other site
743718006915	Trm112p-like protein; Region: Trm112p; cl01066
743718006916	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
743718006917	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
743718006918	active site
743718006919	substrate binding site [chemical binding]; other site
743718006920	metal binding site [ion binding]; metal-binding site
743718006921	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
743718006922	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
743718006923	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
743718006924	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
743718006925	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
743718006926	Transcription factor WhiB; Region: Whib; pfam02467
743718006927	TIGR03089 family protein; Region: TIGR03089
743718006928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718006929	S-adenosylmethionine binding site [chemical binding]; other site
743718006930	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
743718006931	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
743718006932	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
743718006933	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
743718006934	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743718006935	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
743718006936	Probable Catalytic site; other site
743718006937	metal-binding site
743718006938	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
743718006939	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
743718006940	substrate binding site; other site
743718006941	tetramer interface; other site
743718006942	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
743718006943	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
743718006944	NADP binding site [chemical binding]; other site
743718006945	active site
743718006946	putative substrate binding site [chemical binding]; other site
743718006947	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
743718006948	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718006949	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743718006950	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
743718006951	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718006952	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
743718006953	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
743718006954	Ligand binding site; other site
743718006955	Putative Catalytic site; other site
743718006956	DXD motif; other site
743718006957	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
743718006958	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743718006959	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743718006960	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718006961	active site
743718006962	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718006963	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
743718006964	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743718006965	Probable Catalytic site; other site
743718006966	metal-binding site
743718006967	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718006968	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718006969	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
743718006970	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
743718006971	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
743718006972	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
743718006973	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
743718006974	Walker A/P-loop; other site
743718006975	ATP binding site [chemical binding]; other site
743718006976	Q-loop/lid; other site
743718006977	ABC transporter signature motif; other site
743718006978	Walker B; other site
743718006979	D-loop; other site
743718006980	H-loop/switch region; other site
743718006981	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
743718006982	putative carbohydrate binding site [chemical binding]; other site
743718006983	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743718006984	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
743718006985	Probable Catalytic site; other site
743718006986	metal-binding site
743718006987	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743718006988	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718006989	Methyltransferase domain; Region: Methyltransf_23; pfam13489
743718006990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718006991	S-adenosylmethionine binding site [chemical binding]; other site
743718006992	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
743718006993	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
743718006994	NAD binding site [chemical binding]; other site
743718006995	substrate binding site [chemical binding]; other site
743718006996	homodimer interface [polypeptide binding]; other site
743718006997	active site
743718006998	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
743718006999	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
743718007000	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
743718007001	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
743718007002	ATP-grasp domain; Region: ATP-grasp; pfam02222
743718007003	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
743718007004	active site
743718007005	catalytic site [active]
743718007006	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718007007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007008	dimer interface [polypeptide binding]; other site
743718007009	conserved gate region; other site
743718007010	putative PBP binding loops; other site
743718007011	ABC-ATPase subunit interface; other site
743718007012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007013	dimer interface [polypeptide binding]; other site
743718007014	conserved gate region; other site
743718007015	putative PBP binding loops; other site
743718007016	ABC-ATPase subunit interface; other site
743718007017	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718007018	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743718007019	Melibiase; Region: Melibiase; pfam02065
743718007020	MarR family; Region: MarR_2; cl17246
743718007021	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718007022	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743718007023	Predicted membrane protein [Function unknown]; Region: COG2246
743718007024	GtrA-like protein; Region: GtrA; pfam04138
743718007025	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718007026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718007027	dimer interface [polypeptide binding]; other site
743718007028	phosphorylation site [posttranslational modification]
743718007029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718007030	Mg2+ binding site [ion binding]; other site
743718007031	G-X-G motif; other site
743718007032	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718007033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718007034	active site
743718007035	phosphorylation site [posttranslational modification]
743718007036	intermolecular recognition site; other site
743718007037	dimerization interface [polypeptide binding]; other site
743718007038	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718007039	DNA binding site [nucleotide binding]
743718007040	Histidine kinase; Region: HisKA_3; pfam07730
743718007041	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743718007042	ATP binding site [chemical binding]; other site
743718007043	Mg2+ binding site [ion binding]; other site
743718007044	G-X-G motif; other site
743718007045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718007046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718007047	active site
743718007048	phosphorylation site [posttranslational modification]
743718007049	intermolecular recognition site; other site
743718007050	dimerization interface [polypeptide binding]; other site
743718007051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718007052	dimerization interface [polypeptide binding]; other site
743718007053	DNA binding residues [nucleotide binding]
743718007054	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
743718007055	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743718007056	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743718007057	Walker A/P-loop; other site
743718007058	ATP binding site [chemical binding]; other site
743718007059	Q-loop/lid; other site
743718007060	ABC transporter signature motif; other site
743718007061	Walker B; other site
743718007062	D-loop; other site
743718007063	H-loop/switch region; other site
743718007064	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743718007065	FtsX-like permease family; Region: FtsX; pfam02687
743718007066	FtsX-like permease family; Region: FtsX; pfam02687
743718007067	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
743718007068	Transcription factor WhiB; Region: Whib; pfam02467
743718007069	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
743718007070	PAS fold; Region: PAS_4; pfam08448
743718007071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
743718007072	putative active site [active]
743718007073	heme pocket [chemical binding]; other site
743718007074	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
743718007075	Histidine kinase; Region: HisKA_2; pfam07568
743718007076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718007077	ATP binding site [chemical binding]; other site
743718007078	Mg2+ binding site [ion binding]; other site
743718007079	G-X-G motif; other site
743718007080	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
743718007081	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718007082	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743718007083	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
743718007084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007085	dimer interface [polypeptide binding]; other site
743718007086	conserved gate region; other site
743718007087	putative PBP binding loops; other site
743718007088	ABC-ATPase subunit interface; other site
743718007089	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718007090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007091	dimer interface [polypeptide binding]; other site
743718007092	conserved gate region; other site
743718007093	putative PBP binding loops; other site
743718007094	ABC-ATPase subunit interface; other site
743718007095	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
743718007096	beta-galactosidase; Region: BGL; TIGR03356
743718007097	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718007098	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718007099	DNA binding site [nucleotide binding]
743718007100	domain linker motif; other site
743718007101	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
743718007102	putative dimerization interface [polypeptide binding]; other site
743718007103	putative ligand binding site [chemical binding]; other site
743718007104	Proline dehydrogenase; Region: Pro_dh; cl03282
743718007105	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
743718007106	NAD(P) binding site [chemical binding]; other site
743718007107	catalytic residues [active]
743718007108	PAS fold; Region: PAS_4; pfam08448
743718007109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743718007110	putative active site [active]
743718007111	heme pocket [chemical binding]; other site
743718007112	Helix-turn-helix domain; Region: HTH_18; pfam12833
743718007113	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743718007114	BioY family; Region: BioY; pfam02632
743718007115	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743718007116	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743718007117	active site
743718007118	catalytic tetrad [active]
743718007119	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
743718007120	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
743718007121	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
743718007122	NAD(P) binding site [chemical binding]; other site
743718007123	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
743718007124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743718007125	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
743718007126	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
743718007127	ferrochelatase; Reviewed; Region: hemH; PRK00035
743718007128	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
743718007129	C-terminal domain interface [polypeptide binding]; other site
743718007130	active site
743718007131	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
743718007132	active site
743718007133	N-terminal domain interface [polypeptide binding]; other site
743718007134	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
743718007135	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
743718007136	putative trimer interface [polypeptide binding]; other site
743718007137	putative CoA binding site [chemical binding]; other site
743718007138	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
743718007139	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743718007140	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743718007141	MarR family; Region: MarR_2; pfam12802
743718007142	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
743718007143	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
743718007144	catalytic residue [active]
743718007145	putative FPP diphosphate  binding site; other site
743718007146	putative FPP binding hydrophobic cleft; other site
743718007147	dimer interface [polypeptide binding]; other site
743718007148	putative IPP diphosphate binding site; other site
743718007149	Haemolysin-III related; Region: HlyIII; pfam03006
743718007150	Predicted amidohydrolase [General function prediction only]; Region: COG0388
743718007151	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
743718007152	putative active site [active]
743718007153	catalytic triad [active]
743718007154	putative dimer interface [polypeptide binding]; other site
743718007155	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
743718007156	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
743718007157	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
743718007158	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
743718007159	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
743718007160	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
743718007161	threonine dehydratase; Provisional; Region: PRK08198
743718007162	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
743718007163	tetramer interface [polypeptide binding]; other site
743718007164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007165	catalytic residue [active]
743718007166	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
743718007167	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743718007168	cystathionine gamma-synthase; Provisional; Region: PRK07811
743718007169	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743718007170	homodimer interface [polypeptide binding]; other site
743718007171	substrate-cofactor binding pocket; other site
743718007172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007173	catalytic residue [active]
743718007174	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
743718007175	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743718007176	methionine sulfoxide reductase A; Provisional; Region: PRK00058
743718007177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718007178	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743718007179	NAD(P) binding site [chemical binding]; other site
743718007180	active site
743718007181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718007182	Predicted transcriptional regulators [Transcription]; Region: COG1733
743718007183	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743718007184	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
743718007185	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
743718007186	active site
743718007187	DNA binding site [nucleotide binding]
743718007188	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
743718007189	DNA binding site [nucleotide binding]
743718007190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743718007191	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743718007192	dimerization interface [polypeptide binding]; other site
743718007193	Rdx family; Region: Rdx; cl01407
743718007194	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
743718007195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718007196	S-adenosylmethionine binding site [chemical binding]; other site
743718007197	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743718007198	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
743718007199	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
743718007200	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
743718007201	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
743718007202	dimer interface [polypeptide binding]; other site
743718007203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007204	catalytic residue [active]
743718007205	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
743718007206	Bax inhibitor 1 like; Region: BaxI_1; cl17691
743718007207	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
743718007208	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
743718007209	Walker A/P-loop; other site
743718007210	ATP binding site [chemical binding]; other site
743718007211	Q-loop/lid; other site
743718007212	ABC transporter signature motif; other site
743718007213	Walker B; other site
743718007214	D-loop; other site
743718007215	H-loop/switch region; other site
743718007216	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
743718007217	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743718007218	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718007219	dimerization interface [polypeptide binding]; other site
743718007220	putative DNA binding site [nucleotide binding]; other site
743718007221	putative Zn2+ binding site [ion binding]; other site
743718007222	Clp protease; Region: CLP_protease; pfam00574
743718007223	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743718007224	oligomer interface [polypeptide binding]; other site
743718007225	active site residues [active]
743718007226	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
743718007227	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743718007228	oligomer interface [polypeptide binding]; other site
743718007229	active site residues [active]
743718007230	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
743718007231	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718007232	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
743718007233	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
743718007234	Protein of unknown function (DUF501); Region: DUF501; cl00652
743718007235	enolase; Provisional; Region: eno; PRK00077
743718007236	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
743718007237	dimer interface [polypeptide binding]; other site
743718007238	metal binding site [ion binding]; metal-binding site
743718007239	substrate binding pocket [chemical binding]; other site
743718007240	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
743718007241	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
743718007242	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
743718007243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718007244	ATP binding site [chemical binding]; other site
743718007245	putative Mg++ binding site [ion binding]; other site
743718007246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718007247	nucleotide binding region [chemical binding]; other site
743718007248	ATP-binding site [chemical binding]; other site
743718007249	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
743718007250	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
743718007251	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
743718007252	putative active site [active]
743718007253	catalytic residue [active]
743718007254	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
743718007255	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
743718007256	5S rRNA interface [nucleotide binding]; other site
743718007257	CTC domain interface [polypeptide binding]; other site
743718007258	L16 interface [polypeptide binding]; other site
743718007259	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
743718007260	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
743718007261	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718007262	active site
743718007263	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
743718007264	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
743718007265	Substrate binding site; other site
743718007266	Mg++ binding site; other site
743718007267	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
743718007268	active site
743718007269	substrate binding site [chemical binding]; other site
743718007270	CoA binding site [chemical binding]; other site
743718007271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718007272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718007273	MarR family; Region: MarR_2; cl17246
743718007274	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
743718007275	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
743718007276	L-lysine aminotransferase; Provisional; Region: PRK08297
743718007277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743718007278	inhibitor-cofactor binding pocket; inhibition site
743718007279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007280	catalytic residue [active]
743718007281	putative DNA binding site [nucleotide binding]; other site
743718007282	dimerization interface [polypeptide binding]; other site
743718007283	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
743718007284	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
743718007285	putative Zn2+ binding site [ion binding]; other site
743718007286	AsnC family; Region: AsnC_trans_reg; pfam01037
743718007287	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743718007288	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718007289	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743718007290	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
743718007291	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718007292	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
743718007293	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
743718007294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718007295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
743718007296	Domain of unknown function (DUF348); Region: DUF348; pfam03990
743718007297	G5 domain; Region: G5; pfam07501
743718007298	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
743718007299	N-acetyl-D-glucosamine binding site [chemical binding]; other site
743718007300	catalytic residue [active]
743718007301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
743718007302	Domain of unknown function (DUF348); Region: DUF348; pfam03990
743718007303	G5 domain; Region: G5; pfam07501
743718007304	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
743718007305	Domain of unknown function (DUF348); Region: DUF348; pfam03990
743718007306	Domain of unknown function (DUF348); Region: DUF348; pfam03990
743718007307	Domain of unknown function (DUF348); Region: DUF348; pfam03990
743718007308	G5 domain; Region: G5; pfam07501
743718007309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
743718007310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
743718007311	catalytic residue [active]
743718007312	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
743718007313	active site
743718007314	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
743718007315	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
743718007316	active site
743718007317	HIGH motif; other site
743718007318	KMSKS motif; other site
743718007319	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
743718007320	tRNA binding surface [nucleotide binding]; other site
743718007321	anticodon binding site; other site
743718007322	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718007323	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
743718007324	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
743718007325	Isochorismatase family; Region: Isochorismatase; pfam00857
743718007326	catalytic triad [active]
743718007327	metal binding site [ion binding]; metal-binding site
743718007328	conserved cis-peptide bond; other site
743718007329	Predicted methyltransferases [General function prediction only]; Region: COG0313
743718007330	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
743718007331	putative SAM binding site [chemical binding]; other site
743718007332	putative homodimer interface [polypeptide binding]; other site
743718007333	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
743718007334	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
743718007335	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
743718007336	active site
743718007337	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
743718007338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718007339	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
743718007340	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
743718007341	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
743718007342	active site
743718007343	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
743718007344	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
743718007345	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
743718007346	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
743718007347	H+ Antiporter protein; Region: 2A0121; TIGR00900
743718007348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718007349	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
743718007350	AAA domain; Region: AAA_33; pfam13671
743718007351	mannonate dehydratase; Region: uxuA; TIGR00695
743718007352	mannonate dehydratase; Provisional; Region: PRK03906
743718007353	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718007354	FOG: PKD repeat [General function prediction only]; Region: COG3291
743718007355	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718007356	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
743718007357	metal binding site [ion binding]; metal-binding site
743718007358	ligand binding site [chemical binding]; other site
743718007359	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718007360	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718007361	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718007362	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743718007363	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
743718007364	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
743718007365	Walker A/P-loop; other site
743718007366	ATP binding site [chemical binding]; other site
743718007367	Q-loop/lid; other site
743718007368	ABC transporter signature motif; other site
743718007369	Walker B; other site
743718007370	D-loop; other site
743718007371	H-loop/switch region; other site
743718007372	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
743718007373	NMT1/THI5 like; Region: NMT1; pfam09084
743718007374	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
743718007375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007376	dimer interface [polypeptide binding]; other site
743718007377	conserved gate region; other site
743718007378	ABC-ATPase subunit interface; other site
743718007379	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718007380	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743718007381	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718007382	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718007383	DNA binding site [nucleotide binding]
743718007384	domain linker motif; other site
743718007385	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718007386	dimerization interface [polypeptide binding]; other site
743718007387	ligand binding site [chemical binding]; other site
743718007388	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743718007389	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743718007390	DinB superfamily; Region: DinB_2; pfam12867
743718007391	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718007392	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
743718007393	ATP binding site [chemical binding]; other site
743718007394	putative Mg++ binding site [ion binding]; other site
743718007395	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718007396	nucleotide binding region [chemical binding]; other site
743718007397	ATP-binding site [chemical binding]; other site
743718007398	Vi polysaccharide export protein VexE; Provisional; Region: PRK15174
743718007399	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743718007400	non-specific DNA interactions [nucleotide binding]; other site
743718007401	DNA binding site [nucleotide binding]
743718007402	sequence specific DNA binding site [nucleotide binding]; other site
743718007403	putative cAMP binding site [chemical binding]; other site
743718007404	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743718007405	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743718007406	xylose isomerase; Provisional; Region: PRK12677
743718007407	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
743718007408	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743718007409	nucleotide binding site [chemical binding]; other site
743718007410	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743718007411	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
743718007412	folate binding site [chemical binding]; other site
743718007413	NADP+ binding site [chemical binding]; other site
743718007414	thymidylate synthase; Reviewed; Region: thyA; PRK01827
743718007415	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
743718007416	dimerization interface [polypeptide binding]; other site
743718007417	active site
743718007418	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
743718007419	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718007420	putative ADP-binding pocket [chemical binding]; other site
743718007421	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
743718007422	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
743718007423	hydrophobic ligand binding site; other site
743718007424	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
743718007425	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718007426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007427	homodimer interface [polypeptide binding]; other site
743718007428	catalytic residue [active]
743718007429	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743718007430	Beta-lactamase; Region: Beta-lactamase; pfam00144
743718007431	Predicted transcriptional regulators [Transcription]; Region: COG1725
743718007432	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743718007433	DNA-binding site [nucleotide binding]; DNA binding site
743718007434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743718007435	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
743718007436	Walker A/P-loop; other site
743718007437	ATP binding site [chemical binding]; other site
743718007438	Q-loop/lid; other site
743718007439	ABC transporter signature motif; other site
743718007440	Walker B; other site
743718007441	D-loop; other site
743718007442	H-loop/switch region; other site
743718007443	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
743718007444	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718007445	Ligand Binding Site [chemical binding]; other site
743718007446	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718007447	Ligand Binding Site [chemical binding]; other site
743718007448	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743718007449	NlpC/P60 family; Region: NLPC_P60; pfam00877
743718007450	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743718007451	NlpC/P60 family; Region: NLPC_P60; pfam00877
743718007452	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
743718007453	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
743718007454	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
743718007455	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
743718007456	phosphoserine aminotransferase; Provisional; Region: PRK03080
743718007457	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743718007458	catalytic residue [active]
743718007459	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
743718007460	H+ Antiporter protein; Region: 2A0121; TIGR00900
743718007461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718007462	putative substrate translocation pore; other site
743718007463	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743718007464	MarR family; Region: MarR; pfam01047
743718007465	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
743718007466	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
743718007467	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743718007468	DNA-binding site [nucleotide binding]; DNA binding site
743718007469	RNA-binding motif; other site
743718007470	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
743718007471	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
743718007472	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
743718007473	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743718007474	ATP binding site [chemical binding]; other site
743718007475	putative Mg++ binding site [ion binding]; other site
743718007476	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743718007477	nucleotide binding region [chemical binding]; other site
743718007478	ATP-binding site [chemical binding]; other site
743718007479	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718007480	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
743718007481	Domain of unknown function (DUF202); Region: DUF202; cl09954
743718007482	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743718007483	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743718007484	Repair protein; Region: Repair_PSII; pfam04536
743718007485	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
743718007486	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
743718007487	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
743718007488	catalytic triad [active]
743718007489	LabA_like proteins; Region: LabA_like; cd06167
743718007490	putative metal binding site [ion binding]; other site
743718007491	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718007492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718007493	active site
743718007494	phosphorylation site [posttranslational modification]
743718007495	intermolecular recognition site; other site
743718007496	dimerization interface [polypeptide binding]; other site
743718007497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718007498	DNA binding site [nucleotide binding]
743718007499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718007500	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743718007501	dimerization interface [polypeptide binding]; other site
743718007502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718007503	dimer interface [polypeptide binding]; other site
743718007504	phosphorylation site [posttranslational modification]
743718007505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718007506	ATP binding site [chemical binding]; other site
743718007507	Mg2+ binding site [ion binding]; other site
743718007508	G-X-G motif; other site
743718007509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
743718007510	Proteins of 100 residues with WXG; Region: WXG100; cl02005
743718007511	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
743718007512	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
743718007513	ring oligomerisation interface [polypeptide binding]; other site
743718007514	ATP/Mg binding site [chemical binding]; other site
743718007515	stacking interactions; other site
743718007516	hinge regions; other site
743718007517	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743718007518	DNA-binding site [nucleotide binding]; DNA binding site
743718007519	RNA-binding motif; other site
743718007520	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
743718007521	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
743718007522	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
743718007523	ligand binding site [chemical binding]; other site
743718007524	active site
743718007525	UGI interface [polypeptide binding]; other site
743718007526	catalytic site [active]
743718007527	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
743718007528	active site
743718007529	catalytic triad [active]
743718007530	oxyanion hole [active]
743718007531	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
743718007532	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
743718007533	catalytic residues [active]
743718007534	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
743718007535	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743718007536	Catalytic domain of Protein Kinases; Region: PKc; cd00180
743718007537	active site
743718007538	ATP binding site [chemical binding]; other site
743718007539	substrate binding site [chemical binding]; other site
743718007540	activation loop (A-loop); other site
743718007541	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
743718007542	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
743718007543	active site
743718007544	homotetramer interface [polypeptide binding]; other site
743718007545	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
743718007546	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
743718007547	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
743718007548	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
743718007549	Walker A/P-loop; other site
743718007550	ATP binding site [chemical binding]; other site
743718007551	Q-loop/lid; other site
743718007552	ABC transporter signature motif; other site
743718007553	Walker B; other site
743718007554	D-loop; other site
743718007555	H-loop/switch region; other site
743718007556	TOBE domain; Region: TOBE_2; pfam08402
743718007557	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
743718007558	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
743718007559	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
743718007560	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743718007561	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
743718007562	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
743718007563	active site
743718007564	HIGH motif; other site
743718007565	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
743718007566	KMSKS motif; other site
743718007567	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743718007568	tRNA binding surface [nucleotide binding]; other site
743718007569	anticodon binding site; other site
743718007570	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743718007571	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743718007572	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718007573	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084
743718007574	homotrimer interaction site [polypeptide binding]; other site
743718007575	zinc binding site [ion binding]; other site
743718007576	CDP-binding sites; other site
743718007577	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718007578	active site
743718007579	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
743718007580	Septum formation; Region: Septum_form; pfam13845
743718007581	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
743718007582	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
743718007583	Walker A/P-loop; other site
743718007584	ATP binding site [chemical binding]; other site
743718007585	Q-loop/lid; other site
743718007586	ABC transporter signature motif; other site
743718007587	Walker B; other site
743718007588	D-loop; other site
743718007589	H-loop/switch region; other site
743718007590	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
743718007591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007592	dimer interface [polypeptide binding]; other site
743718007593	conserved gate region; other site
743718007594	putative PBP binding loops; other site
743718007595	ABC-ATPase subunit interface; other site
743718007596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007597	dimer interface [polypeptide binding]; other site
743718007598	conserved gate region; other site
743718007599	putative PBP binding loops; other site
743718007600	ABC-ATPase subunit interface; other site
743718007601	PBP superfamily domain; Region: PBP_like_2; cl17296
743718007602	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718007603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718007604	active site
743718007605	phosphorylation site [posttranslational modification]
743718007606	intermolecular recognition site; other site
743718007607	dimerization interface [polypeptide binding]; other site
743718007608	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718007609	DNA binding site [nucleotide binding]
743718007610	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
743718007611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718007612	dimer interface [polypeptide binding]; other site
743718007613	phosphorylation site [posttranslational modification]
743718007614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718007615	ATP binding site [chemical binding]; other site
743718007616	Mg2+ binding site [ion binding]; other site
743718007617	G-X-G motif; other site
743718007618	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
743718007619	PhoU domain; Region: PhoU; pfam01895
743718007620	PhoU domain; Region: PhoU; pfam01895
743718007621	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743718007622	catalytic core [active]
743718007623	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
743718007624	Domain of unknown function (DUF385); Region: DUF385; pfam04075
743718007625	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
743718007626	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
743718007627	putative ADP-binding pocket [chemical binding]; other site
743718007628	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
743718007629	Lsr2; Region: Lsr2; pfam11774
743718007630	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
743718007631	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
743718007632	dimer interface [polypeptide binding]; other site
743718007633	putative anticodon binding site; other site
743718007634	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
743718007635	motif 1; other site
743718007636	dimer interface [polypeptide binding]; other site
743718007637	active site
743718007638	motif 2; other site
743718007639	motif 3; other site
743718007640	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
743718007641	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
743718007642	dimerization interface [polypeptide binding]; other site
743718007643	active site
743718007644	L-aspartate oxidase; Provisional; Region: PRK07804
743718007645	L-aspartate oxidase; Provisional; Region: PRK06175
743718007646	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
743718007647	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
743718007648	tetramerization interface [polypeptide binding]; other site
743718007649	active site
743718007650	Pantoate-beta-alanine ligase; Region: PanC; cd00560
743718007651	pantoate--beta-alanine ligase; Region: panC; TIGR00018
743718007652	active site
743718007653	ATP-binding site [chemical binding]; other site
743718007654	pantoate-binding site; other site
743718007655	HXXH motif; other site
743718007656	Rossmann-like domain; Region: Rossmann-like; pfam10727
743718007657	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
743718007658	Bacterial PH domain; Region: DUF304; pfam03703
743718007659	Bacterial PH domain; Region: DUF304; pfam03703
743718007660	Bacterial PH domain; Region: DUF304; pfam03703
743718007661	Uncharacterized conserved protein [Function unknown]; Region: COG3402
743718007662	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
743718007663	Dihydroneopterin aldolase; Region: FolB; smart00905
743718007664	active site
743718007665	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
743718007666	catalytic center binding site [active]
743718007667	ATP binding site [chemical binding]; other site
743718007668	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
743718007669	dihydropteroate synthase; Region: DHPS; TIGR01496
743718007670	substrate binding pocket [chemical binding]; other site
743718007671	inhibitor binding site; inhibition site
743718007672	GTP cyclohydrolase I; Provisional; Region: PLN03044
743718007673	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
743718007674	homodecamer interface [polypeptide binding]; other site
743718007675	active site
743718007676	putative catalytic site residues [active]
743718007677	zinc binding site [ion binding]; other site
743718007678	GTP-CH-I/GFRP interaction surface; other site
743718007679	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
743718007680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718007681	Walker A motif; other site
743718007682	ATP binding site [chemical binding]; other site
743718007683	Walker B motif; other site
743718007684	arginine finger; other site
743718007685	Peptidase family M41; Region: Peptidase_M41; pfam01434
743718007686	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718007687	active site
743718007688	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
743718007689	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
743718007690	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
743718007691	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
743718007692	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
743718007693	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
743718007694	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
743718007695	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
743718007696	dimer interface [polypeptide binding]; other site
743718007697	substrate binding site [chemical binding]; other site
743718007698	metal binding sites [ion binding]; metal-binding site
743718007699	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743718007700	NlpC/P60 family; Region: NLPC_P60; pfam00877
743718007701	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
743718007702	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743718007703	homodimer interface [polypeptide binding]; other site
743718007704	substrate-cofactor binding pocket; other site
743718007705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718007706	catalytic residue [active]
743718007707	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
743718007708	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
743718007709	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718007710	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
743718007711	dimer interface [polypeptide binding]; other site
743718007712	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
743718007713	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743718007714	NAD(P) binding site [chemical binding]; other site
743718007715	Domain of unknown function DUF77; Region: DUF77; pfam01910
743718007716	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
743718007717	dimer interface [polypeptide binding]; other site
743718007718	phosphate binding site [ion binding]; other site
743718007719	Guanylyl transferase CofC like; Region: CofC; cl17472
743718007720	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
743718007721	putative FMN binding site [chemical binding]; other site
743718007722	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
743718007723	FAD binding domain; Region: FAD_binding_4; pfam01565
743718007724	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743718007725	Cysteine-rich domain; Region: CCG; pfam02754
743718007726	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743718007727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718007728	NAD(P) binding site [chemical binding]; other site
743718007729	active site
743718007730	OsmC-like protein; Region: OsmC; cl00767
743718007731	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
743718007732	putative active site [active]
743718007733	dimerization interface [polypeptide binding]; other site
743718007734	putative tRNAtyr binding site [nucleotide binding]; other site
743718007735	L-asparaginase II; Region: Asparaginase_II; pfam06089
743718007736	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
743718007737	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
743718007738	putative active site [active]
743718007739	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
743718007740	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
743718007741	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
743718007742	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
743718007743	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
743718007744	heme-binding site [chemical binding]; other site
743718007745	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
743718007746	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743718007747	catalytic residues [active]
743718007748	YceI-like domain; Region: YceI; smart00867
743718007749	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718007750	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718007751	DNA binding site [nucleotide binding]
743718007752	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743718007753	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743718007754	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
743718007755	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743718007756	minor groove reading motif; other site
743718007757	helix-hairpin-helix signature motif; other site
743718007758	substrate binding pocket [chemical binding]; other site
743718007759	active site
743718007760	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
743718007761	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743718007762	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743718007763	ligand binding site [chemical binding]; other site
743718007764	flexible hinge region; other site
743718007765	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743718007766	putative switch regulator; other site
743718007767	non-specific DNA interactions [nucleotide binding]; other site
743718007768	DNA binding site [nucleotide binding]
743718007769	sequence specific DNA binding site [nucleotide binding]; other site
743718007770	putative cAMP binding site [chemical binding]; other site
743718007771	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743718007772	homotrimer interaction site [polypeptide binding]; other site
743718007773	putative active site [active]
743718007774	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
743718007775	homotrimer interaction site [polypeptide binding]; other site
743718007776	putative active site [active]
743718007777	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
743718007778	Transglycosylase; Region: Transgly; pfam00912
743718007779	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
743718007780	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
743718007781	phosphodiesterase YaeI; Provisional; Region: PRK11340
743718007782	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
743718007783	putative active site [active]
743718007784	putative metal binding site [ion binding]; other site
743718007785	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
743718007786	Amidase; Region: Amidase; cl11426
743718007787	amidase; Provisional; Region: PRK06828
743718007788	Amidase; Region: Amidase; cl11426
743718007789	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
743718007790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743718007791	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718007792	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
743718007793	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
743718007794	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
743718007795	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
743718007796	nudix motif; other site
743718007797	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
743718007798	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
743718007799	catalytic triad [active]
743718007800	Sodium Bile acid symporter family; Region: SBF; pfam01758
743718007801	bile acid transporter; Region: bass; TIGR00841
743718007802	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
743718007803	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718007804	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718007805	Walker A/P-loop; other site
743718007806	ATP binding site [chemical binding]; other site
743718007807	Q-loop/lid; other site
743718007808	ABC transporter signature motif; other site
743718007809	Walker B; other site
743718007810	D-loop; other site
743718007811	H-loop/switch region; other site
743718007812	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
743718007813	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
743718007814	aspartate kinase; Reviewed; Region: PRK06635
743718007815	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
743718007816	putative nucleotide binding site [chemical binding]; other site
743718007817	putative catalytic residues [active]
743718007818	putative Mg ion binding site [ion binding]; other site
743718007819	putative aspartate binding site [chemical binding]; other site
743718007820	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
743718007821	putative allosteric regulatory site; other site
743718007822	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
743718007823	putative allosteric regulatory residue; other site
743718007824	EamA-like transporter family; Region: EamA; pfam00892
743718007825	hypothetical protein; Provisional; Region: PRK10621
743718007826	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743718007827	recombination protein RecR; Reviewed; Region: recR; PRK00076
743718007828	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
743718007829	RecR protein; Region: RecR; pfam02132
743718007830	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
743718007831	putative active site [active]
743718007832	putative metal-binding site [ion binding]; other site
743718007833	tetramer interface [polypeptide binding]; other site
743718007834	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
743718007836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718007837	active site
743718007838	phosphorylation site [posttranslational modification]
743718007839	intermolecular recognition site; other site
743718007840	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718007841	DNA binding residues [nucleotide binding]
743718007842	dimerization interface [polypeptide binding]; other site
743718007843	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718007844	Histidine kinase; Region: HisKA_3; pfam07730
743718007845	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743718007846	ATP binding site [chemical binding]; other site
743718007847	Mg2+ binding site [ion binding]; other site
743718007848	G-X-G motif; other site
743718007849	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718007850	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
743718007851	Walker A/P-loop; other site
743718007852	ATP binding site [chemical binding]; other site
743718007853	Q-loop/lid; other site
743718007854	ABC transporter signature motif; other site
743718007855	Walker B; other site
743718007856	D-loop; other site
743718007857	H-loop/switch region; other site
743718007858	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
743718007859	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743718007860	nudix motif; other site
743718007861	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
743718007862	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743718007863	Beta-lactamase; Region: Beta-lactamase; pfam00144
743718007864	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
743718007865	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
743718007866	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
743718007867	putative metal binding site [ion binding]; other site
743718007868	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743718007869	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
743718007870	nudix motif; other site
743718007871	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
743718007872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743718007873	Walker A motif; other site
743718007874	ATP binding site [chemical binding]; other site
743718007875	Walker B motif; other site
743718007876	arginine finger; other site
743718007877	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
743718007878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007879	ABC-ATPase subunit interface; other site
743718007880	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
743718007881	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
743718007882	Walker A/P-loop; other site
743718007883	ATP binding site [chemical binding]; other site
743718007884	Q-loop/lid; other site
743718007885	ABC transporter signature motif; other site
743718007886	Walker B; other site
743718007887	D-loop; other site
743718007888	H-loop/switch region; other site
743718007889	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718007890	NIL domain; Region: NIL; pfam09383
743718007891	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
743718007892	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
743718007893	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
743718007894	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
743718007895	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
743718007896	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
743718007897	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
743718007898	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
743718007899	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
743718007900	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
743718007901	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
743718007902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743718007903	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
743718007904	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743718007905	acyl-coenzyme A oxidase; Region: PLN02526
743718007906	active site
743718007907	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743718007908	nudix motif; other site
743718007909	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
743718007910	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
743718007911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718007912	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
743718007913	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743718007914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743718007915	RibD C-terminal domain; Region: RibD_C; cl17279
743718007916	Domain of unknown function (DUF385); Region: DUF385; cl04387
743718007917	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743718007918	conserved cys residue [active]
743718007919	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743718007920	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743718007921	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718007922	NAD(P) binding site [chemical binding]; other site
743718007923	active site
743718007924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
743718007925	Transposase; Region: HTH_Tnp_1; cl17663
743718007926	Transposase; Region: HTH_Tnp_1; cl17663
743718007927	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
743718007928	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
743718007929	NAD-dependent deacetylase; Provisional; Region: PRK00481
743718007930	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
743718007931	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743718007932	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
743718007933	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
743718007934	nucleoside/Zn binding site; other site
743718007935	dimer interface [polypeptide binding]; other site
743718007936	catalytic motif [active]
743718007937	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743718007938	active site
743718007939	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743718007940	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718007941	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718007942	DNA binding residues [nucleotide binding]
743718007943	Putative zinc-finger; Region: zf-HC2; pfam13490
743718007944	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
743718007945	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
743718007946	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743718007947	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743718007948	DNA binding residues [nucleotide binding]
743718007949	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
743718007950	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
743718007951	HSP70 interaction site [polypeptide binding]; other site
743718007952	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
743718007953	substrate binding site [polypeptide binding]; other site
743718007954	dimer interface [polypeptide binding]; other site
743718007955	GrpE; Region: GrpE; pfam01025
743718007956	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
743718007957	dimer interface [polypeptide binding]; other site
743718007958	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
743718007959	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
743718007960	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
743718007961	nucleotide binding site [chemical binding]; other site
743718007962	NEF interaction site [polypeptide binding]; other site
743718007963	SBD interface [polypeptide binding]; other site
743718007964	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
743718007965	active site
743718007966	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
743718007967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718007968	S-adenosylmethionine binding site [chemical binding]; other site
743718007969	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743718007970	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
743718007971	putative acyl-acceptor binding pocket; other site
743718007972	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
743718007973	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
743718007974	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
743718007975	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
743718007976	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
743718007977	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718007978	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718007979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007980	dimer interface [polypeptide binding]; other site
743718007981	conserved gate region; other site
743718007982	putative PBP binding loops; other site
743718007983	ABC-ATPase subunit interface; other site
743718007984	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718007985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718007986	dimer interface [polypeptide binding]; other site
743718007987	conserved gate region; other site
743718007988	putative PBP binding loops; other site
743718007989	ABC-ATPase subunit interface; other site
743718007990	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718007991	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
743718007992	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
743718007993	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
743718007994	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
743718007995	HIGH motif; other site
743718007996	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
743718007997	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743718007998	active site
743718007999	KMSKS motif; other site
743718008000	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743718008001	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743718008002	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
743718008003	Zn binding site [ion binding]; other site
743718008004	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743718008005	Ligand Binding Site [chemical binding]; other site
743718008006	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743718008007	Ligand Binding Site [chemical binding]; other site
743718008008	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
743718008009	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
743718008010	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743718008011	Histidine kinase; Region: HisKA_3; pfam07730
743718008012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718008013	ATP binding site [chemical binding]; other site
743718008014	Mg2+ binding site [ion binding]; other site
743718008015	G-X-G motif; other site
743718008016	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718008017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718008018	active site
743718008019	phosphorylation site [posttranslational modification]
743718008020	intermolecular recognition site; other site
743718008021	dimerization interface [polypeptide binding]; other site
743718008022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718008023	DNA binding residues [nucleotide binding]
743718008024	dimerization interface [polypeptide binding]; other site
743718008025	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
743718008026	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743718008027	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
743718008028	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
743718008029	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
743718008030	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718008031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008032	dimer interface [polypeptide binding]; other site
743718008033	conserved gate region; other site
743718008034	putative PBP binding loops; other site
743718008035	ABC-ATPase subunit interface; other site
743718008036	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
743718008037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008038	dimer interface [polypeptide binding]; other site
743718008039	conserved gate region; other site
743718008040	putative PBP binding loops; other site
743718008041	ABC-ATPase subunit interface; other site
743718008042	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718008043	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743718008044	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718008045	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718008046	DNA binding site [nucleotide binding]
743718008047	domain linker motif; other site
743718008048	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718008049	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718008050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718008051	active site
743718008052	phosphorylation site [posttranslational modification]
743718008053	intermolecular recognition site; other site
743718008054	dimerization interface [polypeptide binding]; other site
743718008055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718008056	DNA binding site [nucleotide binding]
743718008057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718008058	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743718008059	dimerization interface [polypeptide binding]; other site
743718008060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718008061	dimer interface [polypeptide binding]; other site
743718008062	phosphorylation site [posttranslational modification]
743718008063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718008064	ATP binding site [chemical binding]; other site
743718008065	Mg2+ binding site [ion binding]; other site
743718008066	G-X-G motif; other site
743718008067	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
743718008068	Phosphotransferase enzyme family; Region: APH; pfam01636
743718008069	active site
743718008070	ATP binding site [chemical binding]; other site
743718008071	substrate binding site [chemical binding]; other site
743718008072	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
743718008073	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
743718008074	active site
743718008075	dimer interface [polypeptide binding]; other site
743718008076	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
743718008077	dimer interface [polypeptide binding]; other site
743718008078	active site
743718008079	Protease prsW family; Region: PrsW-protease; pfam13367
743718008080	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
743718008081	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
743718008082	Walker A/P-loop; other site
743718008083	ATP binding site [chemical binding]; other site
743718008084	Q-loop/lid; other site
743718008085	ABC transporter signature motif; other site
743718008086	Walker B; other site
743718008087	D-loop; other site
743718008088	H-loop/switch region; other site
743718008089	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
743718008090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008091	dimer interface [polypeptide binding]; other site
743718008092	conserved gate region; other site
743718008093	putative PBP binding loops; other site
743718008094	ABC-ATPase subunit interface; other site
743718008095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008096	dimer interface [polypeptide binding]; other site
743718008097	conserved gate region; other site
743718008098	putative PBP binding loops; other site
743718008099	ABC-ATPase subunit interface; other site
743718008100	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
743718008101	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
743718008102	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
743718008103	PAS fold; Region: PAS_3; pfam08447
743718008104	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
743718008105	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
743718008106	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
743718008107	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743718008108	Predicted transcriptional regulator [Transcription]; Region: COG1959
743718008109	Transcriptional regulator; Region: Rrf2; pfam02082
743718008110	dimerization interface [polypeptide binding]; other site
743718008111	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
743718008112	putative active cleft [active]
743718008113	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
743718008114	Na binding site [ion binding]; other site
743718008115	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
743718008116	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
743718008117	G1 box; other site
743718008118	GTP/Mg2+ binding site [chemical binding]; other site
743718008119	G2 box; other site
743718008120	Switch I region; other site
743718008121	G3 box; other site
743718008122	Switch II region; other site
743718008123	G4 box; other site
743718008124	G5 box; other site
743718008125	Protein of unknown function (DUF742); Region: DUF742; pfam05331
743718008126	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
743718008127	Nitrate and nitrite sensing; Region: NIT; pfam08376
743718008128	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718008129	HAMP domain; Region: HAMP; pfam00672
743718008130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718008131	ATP binding site [chemical binding]; other site
743718008132	G-X-G motif; other site
743718008133	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
743718008134	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
743718008135	NAD(P) binding site [chemical binding]; other site
743718008136	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
743718008137	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
743718008138	Protein of unknown function (DUF805); Region: DUF805; pfam05656
743718008139	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
743718008140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008141	dimer interface [polypeptide binding]; other site
743718008142	conserved gate region; other site
743718008143	putative PBP binding loops; other site
743718008144	ABC-ATPase subunit interface; other site
743718008145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008146	dimer interface [polypeptide binding]; other site
743718008147	conserved gate region; other site
743718008148	putative PBP binding loops; other site
743718008149	ABC-ATPase subunit interface; other site
743718008150	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743718008151	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
743718008152	active site
743718008153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718008154	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
743718008155	active site
743718008156	motif I; other site
743718008157	motif II; other site
743718008158	seryl-tRNA synthetase; Provisional; Region: PRK05431
743718008159	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
743718008160	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
743718008161	dimer interface [polypeptide binding]; other site
743718008162	active site
743718008163	motif 1; other site
743718008164	motif 2; other site
743718008165	motif 3; other site
743718008166	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
743718008167	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
743718008168	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743718008169	active site
743718008170	exopolyphosphatase; Region: exo_poly_only; TIGR03706
743718008171	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
743718008172	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
743718008173	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
743718008174	NAD(P) binding pocket [chemical binding]; other site
743718008175	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
743718008176	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
743718008177	substrate binding site [chemical binding]; other site
743718008178	active site
743718008179	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
743718008180	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
743718008181	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
743718008182	domain interfaces; other site
743718008183	active site
743718008184	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
743718008185	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
743718008186	active site
743718008187	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
743718008188	dimer interface [polypeptide binding]; other site
743718008189	active site
743718008190	Schiff base residues; other site
743718008191	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
743718008192	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743718008193	inhibitor-cofactor binding pocket; inhibition site
743718008194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718008195	catalytic residue [active]
743718008196	Proteins of 100 residues with WXG; Region: WXG100; cl02005
743718008197	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
743718008198	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743718008199	active site
743718008200	Zn binding site [ion binding]; other site
743718008201	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
743718008202	putative homodimer interface [polypeptide binding]; other site
743718008203	putative homotetramer interface [polypeptide binding]; other site
743718008204	putative allosteric switch controlling residues; other site
743718008205	putative metal binding site [ion binding]; other site
743718008206	putative homodimer-homodimer interface [polypeptide binding]; other site
743718008207	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743718008208	metal-binding site [ion binding]
743718008209	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743718008210	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743718008211	metal-binding site [ion binding]
743718008212	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743718008213	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743718008214	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743718008215	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743718008216	Walker A/P-loop; other site
743718008217	ATP binding site [chemical binding]; other site
743718008218	Q-loop/lid; other site
743718008219	ABC transporter signature motif; other site
743718008220	Walker B; other site
743718008221	D-loop; other site
743718008222	H-loop/switch region; other site
743718008223	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718008224	putative Zn2+ binding site [ion binding]; other site
743718008225	putative DNA binding site [nucleotide binding]; other site
743718008226	CAAX protease self-immunity; Region: Abi; pfam02517
743718008227	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
743718008228	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718008229	Walker A/P-loop; other site
743718008230	ATP binding site [chemical binding]; other site
743718008231	Q-loop/lid; other site
743718008232	ABC transporter signature motif; other site
743718008233	Walker B; other site
743718008234	D-loop; other site
743718008235	H-loop/switch region; other site
743718008236	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718008237	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
743718008238	Walker A/P-loop; other site
743718008239	ATP binding site [chemical binding]; other site
743718008240	Q-loop/lid; other site
743718008241	ABC transporter signature motif; other site
743718008242	Walker B; other site
743718008243	D-loop; other site
743718008244	H-loop/switch region; other site
743718008245	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
743718008246	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
743718008247	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
743718008248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743718008249	dimer interface [polypeptide binding]; other site
743718008250	conserved gate region; other site
743718008251	putative PBP binding loops; other site
743718008252	ABC-ATPase subunit interface; other site
743718008253	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
743718008254	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
743718008255	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
743718008256	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
743718008257	IHF dimer interface [polypeptide binding]; other site
743718008258	IHF - DNA interface [nucleotide binding]; other site
743718008259	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
743718008260	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
743718008261	active site
743718008262	metal binding site [ion binding]; metal-binding site
743718008263	nudix motif; other site
743718008264	CopC domain; Region: CopC; pfam04234
743718008265	NAD synthetase; Reviewed; Region: nadE; PRK02628
743718008266	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
743718008267	multimer interface [polypeptide binding]; other site
743718008268	active site
743718008269	catalytic triad [active]
743718008270	protein interface 1 [polypeptide binding]; other site
743718008271	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
743718008272	homodimer interface [polypeptide binding]; other site
743718008273	NAD binding pocket [chemical binding]; other site
743718008274	ATP binding pocket [chemical binding]; other site
743718008275	Mg binding site [ion binding]; other site
743718008276	active-site loop [active]
743718008277	hypothetical protein; Provisional; Region: PRK11573
743718008278	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718008279	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718008280	Transporter associated domain; Region: CorC_HlyC; smart01091
743718008281	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718008282	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718008283	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
743718008284	Domain of unknown function DUF21; Region: DUF21; pfam01595
743718008285	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743718008286	Transporter associated domain; Region: CorC_HlyC; smart01091
743718008287	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
743718008288	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
743718008289	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
743718008290	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
743718008291	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
743718008292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718008293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718008294	homodimer interface [polypeptide binding]; other site
743718008295	catalytic residue [active]
743718008296	AAA ATPase domain; Region: AAA_16; pfam13191
743718008297	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718008298	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718008299	DNA binding residues [nucleotide binding]
743718008300	dimerization interface [polypeptide binding]; other site
743718008301	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
743718008302	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
743718008303	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
743718008304	RNA polymerase factor sigma-70; Validated; Region: PRK08241
743718008305	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718008306	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743718008307	DNA binding residues [nucleotide binding]
743718008308	SnoaL-like domain; Region: SnoaL_2; pfam12680
743718008309	CrcB-like protein; Region: CRCB; pfam02537
743718008310	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
743718008311	5'-3' exonuclease; Region: 53EXOc; smart00475
743718008312	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
743718008313	active site
743718008314	metal binding site 1 [ion binding]; metal-binding site
743718008315	putative 5' ssDNA interaction site; other site
743718008316	metal binding site 3; metal-binding site
743718008317	metal binding site 2 [ion binding]; metal-binding site
743718008318	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
743718008319	putative DNA binding site [nucleotide binding]; other site
743718008320	putative metal binding site [ion binding]; other site
743718008321	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
743718008322	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718008323	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
743718008324	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718008325	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
743718008326	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
743718008327	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743718008328	extended (e) SDRs; Region: SDR_e; cd08946
743718008329	NAD(P) binding site [chemical binding]; other site
743718008330	active site
743718008331	substrate binding site [chemical binding]; other site
743718008332	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
743718008333	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743718008334	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718008335	Putative zinc-finger; Region: zf-HC2; pfam13490
743718008336	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
743718008337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743718008338	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
743718008339	YceI-like domain; Region: YceI; pfam04264
743718008340	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
743718008341	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
743718008342	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
743718008343	substrate binding site [chemical binding]; other site
743718008344	dimer interface [polypeptide binding]; other site
743718008345	ATP binding site [chemical binding]; other site
743718008346	endonuclease IV; Provisional; Region: PRK01060
743718008347	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
743718008348	AP (apurinic/apyrimidinic) site pocket; other site
743718008349	DNA interaction; other site
743718008350	Metal-binding active site; metal-binding site
743718008351	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743718008352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718008353	active site
743718008354	phosphorylation site [posttranslational modification]
743718008355	intermolecular recognition site; other site
743718008356	dimerization interface [polypeptide binding]; other site
743718008357	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743718008358	DNA binding residues [nucleotide binding]
743718008359	dimerization interface [polypeptide binding]; other site
743718008360	Histidine kinase; Region: HisKA_3; pfam07730
743718008361	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743718008362	ATP binding site [chemical binding]; other site
743718008363	Mg2+ binding site [ion binding]; other site
743718008364	G-X-G motif; other site
743718008365	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
743718008366	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
743718008367	Walker A/P-loop; other site
743718008368	ATP binding site [chemical binding]; other site
743718008369	Q-loop/lid; other site
743718008370	ABC transporter signature motif; other site
743718008371	Walker B; other site
743718008372	D-loop; other site
743718008373	H-loop/switch region; other site
743718008374	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
743718008375	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
743718008376	active site
743718008377	substrate binding site [chemical binding]; other site
743718008378	Mg2+ binding site [ion binding]; other site
743718008379	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718008380	dimerization interface [polypeptide binding]; other site
743718008381	putative DNA binding site [nucleotide binding]; other site
743718008382	Predicted transcriptional regulators [Transcription]; Region: COG1695
743718008383	putative Zn2+ binding site [ion binding]; other site
743718008384	PQQ-like domain; Region: PQQ_2; pfam13360
743718008385	Protein of unknown function, DUF606; Region: DUF606; pfam04657
743718008386	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
743718008387	putative hydrophobic ligand binding site [chemical binding]; other site
743718008388	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
743718008389	Domain of unknown function (DUF305); Region: DUF305; pfam03713
743718008390	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
743718008391	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743718008392	DinB superfamily; Region: DinB_2; pfam12867
743718008393	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743718008394	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
743718008395	active site
743718008396	metal binding site [ion binding]; metal-binding site
743718008397	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
743718008398	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743718008399	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
743718008400	PA/protease or protease-like domain interface [polypeptide binding]; other site
743718008401	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
743718008402	Peptidase family M28; Region: Peptidase_M28; pfam04389
743718008403	active site
743718008404	metal binding site [ion binding]; metal-binding site
743718008405	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743718008406	Putative zinc-finger; Region: zf-HC2; pfam13490
743718008407	ornithine cyclodeaminase; Validated; Region: PRK07589
743718008408	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
743718008409	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
743718008410	Amidinotransferase; Region: Amidinotransf; pfam02274
743718008411	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743718008412	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
743718008413	AsnC family; Region: AsnC_trans_reg; pfam01037
743718008414	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
743718008415	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
743718008416	putative active site [active]
743718008417	putative metal binding site [ion binding]; other site
743718008418	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
743718008419	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
743718008420	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
743718008421	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743718008422	DNA binding site [nucleotide binding]
743718008423	active site
743718008424	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
743718008425	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
743718008426	catalytic residues [active]
743718008427	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
743718008428	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
743718008429	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
743718008430	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743718008431	active site
743718008432	catalytic triad [active]
743718008433	oxyanion hole [active]
743718008434	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
743718008435	YCII-related domain; Region: YCII; cl00999
743718008436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743718008437	Coenzyme A binding pocket [chemical binding]; other site
743718008438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743718008439	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
743718008440	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743718008441	Conserved TM helix; Region: TM_helix; pfam05552
743718008442	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
743718008443	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743718008444	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743718008445	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743718008446	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718008447	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743718008448	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
743718008449	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718008450	putative DNA binding site [nucleotide binding]; other site
743718008451	putative Zn2+ binding site [ion binding]; other site
743718008452	Cation efflux family; Region: Cation_efflux; cl00316
743718008453	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
743718008454	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718008455	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743718008456	DNA binding site [nucleotide binding]
743718008457	domain linker motif; other site
743718008458	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743718008459	dimerization interface [polypeptide binding]; other site
743718008460	ligand binding site [chemical binding]; other site
743718008461	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
743718008462	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743718008463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718008464	motif II; other site
743718008465	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
743718008466	Cation efflux family; Region: Cation_efflux; cl00316
743718008467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743718008468	putative DNA binding site [nucleotide binding]; other site
743718008469	putative Zn2+ binding site [ion binding]; other site
743718008470	Domain of unknown function (DUF222); Region: DUF222; pfam02720
743718008471	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743718008472	active site
743718008473	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
743718008474	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
743718008475	Sulfate transporter family; Region: Sulfate_transp; pfam00916
743718008476	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
743718008477	Sulfate transporter family; Region: Sulfate_transp; pfam00916
743718008478	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
743718008479	UDP-glucose 4-epimerase; Region: PLN02240
743718008480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743718008481	NAD(P) binding site [chemical binding]; other site
743718008482	active site
743718008483	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
743718008484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
743718008485	substrate binding pocket [chemical binding]; other site
743718008486	membrane-bound complex binding site; other site
743718008487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743718008488	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743718008489	dimerization interface [polypeptide binding]; other site
743718008490	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743718008491	dimer interface [polypeptide binding]; other site
743718008492	phosphorylation site [posttranslational modification]
743718008493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743718008494	ATP binding site [chemical binding]; other site
743718008495	Mg2+ binding site [ion binding]; other site
743718008496	G-X-G motif; other site
743718008497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743718008498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743718008499	active site
743718008500	phosphorylation site [posttranslational modification]
743718008501	intermolecular recognition site; other site
743718008502	dimerization interface [polypeptide binding]; other site
743718008503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743718008504	DNA binding site [nucleotide binding]
743718008505	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
743718008506	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743718008507	active site
743718008508	motif I; other site
743718008509	motif II; other site
743718008510	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743718008511	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
743718008512	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743718008513	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
743718008514	FAD binding domain; Region: FAD_binding_4; pfam01565
743718008515	Berberine and berberine like; Region: BBE; pfam08031
743718008516	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743718008517	MarR family; Region: MarR_2; pfam12802
743718008518	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
743718008519	active site
743718008520	Family description; Region: UvrD_C_2; pfam13538
743718008521	Trehalose utilisation; Region: ThuA; pfam06283
743718008522	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743718008523	FOG: PKD repeat [General function prediction only]; Region: COG3291
743718008524	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743718008525	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
743718008526	metal binding site [ion binding]; metal-binding site
743718008527	ligand binding site [chemical binding]; other site
743718008528	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743718008529	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743718008530	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
743718008531	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
743718008532	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
743718008533	Walker A/P-loop; other site
743718008534	ATP binding site [chemical binding]; other site
743718008535	Q-loop/lid; other site
743718008536	ABC transporter signature motif; other site
743718008537	Walker B; other site
743718008538	D-loop; other site
743718008539	H-loop/switch region; other site
743718008540	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
743718008541	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
743718008542	Walker A/P-loop; other site
743718008543	ATP binding site [chemical binding]; other site
743718008544	Q-loop/lid; other site
743718008545	ABC transporter signature motif; other site
743718008546	Walker B; other site
743718008547	D-loop; other site
743718008548	H-loop/switch region; other site
743718008549	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
743718008550	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743718008551	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
743718008552	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
743718008553	TM-ABC transporter signature motif; other site
743718008554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743718008555	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
743718008556	TM-ABC transporter signature motif; other site
743718008557	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743718008558	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743718008559	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743718008560	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
743718008561	putative dimerization interface [polypeptide binding]; other site
743718008562	putative ligand binding site [chemical binding]; other site
743718008563	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743718008564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743718008565	replicative DNA helicase; Region: DnaB; TIGR00665
743718008566	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
743718008567	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
743718008568	Walker A motif; other site
743718008569	ATP binding site [chemical binding]; other site
743718008570	Walker B motif; other site
743718008571	DNA binding loops [nucleotide binding]
743718008572	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
743718008573	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
743718008574	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
743718008575	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
743718008576	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
743718008577	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
743718008578	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
743718008579	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
743718008580	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
743718008581	dimer interface [polypeptide binding]; other site
743718008582	ssDNA binding site [nucleotide binding]; other site
743718008583	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743718008584	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
743718008585	Transglycosylase; Region: Transgly; pfam00912
743718008586	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
743718008587	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
743718008588	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718008589	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743718008590	Predicted transcriptional regulators [Transcription]; Region: COG1695
743718008591	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
743718008592	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
743718008593	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
743718008594	H+ Antiporter protein; Region: 2A0121; TIGR00900
743718008595	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
743718008596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743718008597	putative substrate translocation pore; other site
743718008598	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
743718008599	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
743718008600	active site
743718008601	NTP binding site [chemical binding]; other site
743718008602	metal binding triad [ion binding]; metal-binding site
743718008603	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
743718008604	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743718008605	Zn2+ binding site [ion binding]; other site
743718008606	Mg2+ binding site [ion binding]; other site
743718008607	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
743718008608	active site
743718008609	Ap6A binding site [chemical binding]; other site
743718008610	nudix motif; other site
743718008611	metal binding site [ion binding]; metal-binding site
743718008612	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
743718008613	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
743718008614	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743718008615	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743718008616	catalytic residues [active]
743718008617	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
743718008618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743718008619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743718008620	homodimer interface [polypeptide binding]; other site
743718008621	catalytic residue [active]
743718008622	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
743718008623	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
743718008624	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743718008625	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
743718008626	ParB-like nuclease domain; Region: ParBc; pfam02195
743718008627	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
743718008628	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743718008629	Magnesium ion binding site [ion binding]; other site
743718008630	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743718008631	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
743718008632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743718008633	S-adenosylmethionine binding site [chemical binding]; other site
743718008634	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
743718008635	G-X-X-G motif; other site
743718008636	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
743718008637	RxxxH motif; other site
743718008638	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
743718008639	Haemolytic domain; Region: Haemolytic; pfam01809
743718008640	Ribonuclease P; Region: Ribonuclease_P; pfam00825
743718008641	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399