-- dump date 20140619_120147 -- class Genbank::misc_feature -- table misc_feature_note -- id note 575540000001 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540000002 active site 575540000003 ATP binding site [chemical binding]; other site 575540000004 substrate binding site [chemical binding]; other site 575540000005 activation loop (A-loop); other site 575540000006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540000007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540000008 binding surface 575540000009 TPR motif; other site 575540000010 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 575540000011 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 575540000012 active site 575540000013 substrate-binding site [chemical binding]; other site 575540000014 metal-binding site [ion binding] 575540000015 ATP binding site [chemical binding]; other site 575540000016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000017 active site 575540000018 ATP binding site [chemical binding]; other site 575540000019 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540000020 substrate binding site [chemical binding]; other site 575540000021 activation loop (A-loop); other site 575540000022 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 575540000023 Aspartase; Region: Aspartase; cd01357 575540000024 active sites [active] 575540000025 tetramer interface [polypeptide binding]; other site 575540000026 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 575540000027 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 575540000028 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 575540000029 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540000030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540000031 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 575540000032 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 575540000033 active site 575540000034 putative lithium-binding site [ion binding]; other site 575540000035 substrate binding site [chemical binding]; other site 575540000036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540000037 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 575540000038 putative ADP-binding pocket [chemical binding]; other site 575540000039 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 575540000040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 575540000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 575540000042 P-loop; other site 575540000043 Magnesium ion binding site [ion binding]; other site 575540000044 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 575540000045 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 575540000046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000047 binding surface 575540000048 TPR motif; other site 575540000049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540000050 binding surface 575540000051 TPR motif; other site 575540000052 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540000053 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 575540000054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540000055 NAD(P) binding site [chemical binding]; other site 575540000056 active site 575540000057 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 575540000058 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 575540000059 Replication initiator protein A; Region: RPA; cl17860 575540000060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540000061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000062 binding surface 575540000063 TPR motif; other site 575540000064 Global regulator protein family; Region: CsrA; pfam02599 575540000065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 575540000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 575540000067 P-loop; other site 575540000068 Magnesium ion binding site [ion binding]; other site 575540000069 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 575540000070 Magnesium ion binding site [ion binding]; other site 575540000071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540000072 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540000073 NAD(P) binding site [chemical binding]; other site 575540000074 active site 575540000075 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 575540000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540000077 Walker A motif; other site 575540000078 ATP binding site [chemical binding]; other site 575540000079 Walker B motif; other site 575540000080 arginine finger; other site 575540000081 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 575540000082 DnaA box-binding interface [nucleotide binding]; other site 575540000083 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 575540000084 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 575540000085 putative active site [active] 575540000086 catalytic site [active] 575540000087 putative metal binding site [ion binding]; other site 575540000088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 575540000089 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 575540000090 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 575540000091 nudix motif; other site 575540000092 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 575540000093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 575540000094 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 575540000095 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 575540000096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 575540000097 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540000098 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 575540000099 IMP binding site; other site 575540000100 dimer interface [polypeptide binding]; other site 575540000101 partial ornithine binding site; other site 575540000102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540000103 dimerization interface [polypeptide binding]; other site 575540000104 putative DNA binding site [nucleotide binding]; other site 575540000105 putative Zn2+ binding site [ion binding]; other site 575540000106 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 575540000107 SdpI/YhfL protein family; Region: SdpI; pfam13630 575540000108 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 575540000109 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 575540000110 active site 575540000111 substrate binding site [chemical binding]; other site 575540000112 metal binding site [ion binding]; metal-binding site 575540000113 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 575540000114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540000115 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 575540000116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540000117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540000118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540000119 active site 575540000120 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 575540000121 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 575540000122 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 575540000123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540000124 Global regulator protein family; Region: CsrA; pfam02599 575540000125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 575540000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000127 active site 575540000128 phosphorylation site [posttranslational modification] 575540000129 intermolecular recognition site; other site 575540000130 dimerization interface [polypeptide binding]; other site 575540000131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 575540000132 DNA binding site [nucleotide binding] 575540000133 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 575540000134 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 575540000135 Walker A/P-loop; other site 575540000136 ATP binding site [chemical binding]; other site 575540000137 Q-loop/lid; other site 575540000138 ABC transporter signature motif; other site 575540000139 Walker B; other site 575540000140 D-loop; other site 575540000141 H-loop/switch region; other site 575540000142 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 575540000143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540000144 active site 575540000145 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540000146 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 575540000147 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540000148 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540000149 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 575540000150 FlxA-like protein; Region: FlxA; pfam14282 575540000151 Predicted ATPase [General function prediction only]; Region: COG5293 575540000152 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540000153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540000154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540000155 DNA binding residues [nucleotide binding] 575540000156 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 575540000157 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540000158 catalytic triad [active] 575540000159 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540000160 metal ion-dependent adhesion site (MIDAS); other site 575540000161 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 575540000162 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 575540000163 HflX GTPase family; Region: HflX; cd01878 575540000164 G1 box; other site 575540000165 GTP/Mg2+ binding site [chemical binding]; other site 575540000166 Switch I region; other site 575540000167 G2 box; other site 575540000168 G3 box; other site 575540000169 Switch II region; other site 575540000170 G4 box; other site 575540000171 G5 box; other site 575540000172 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 575540000173 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 575540000174 RNA binding site [nucleotide binding]; other site 575540000175 active site 575540000176 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 575540000177 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 575540000178 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 575540000179 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540000180 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540000181 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540000182 structural tetrad; other site 575540000183 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540000184 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540000185 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540000186 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 575540000187 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 575540000188 TPP-binding site [chemical binding]; other site 575540000189 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 575540000190 dimer interface [polypeptide binding]; other site 575540000191 PYR/PP interface [polypeptide binding]; other site 575540000192 TPP binding site [chemical binding]; other site 575540000193 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 575540000194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 575540000195 E3 interaction surface; other site 575540000196 lipoyl attachment site [posttranslational modification]; other site 575540000197 e3 binding domain; Region: E3_binding; pfam02817 575540000198 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 575540000199 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 575540000200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540000201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540000202 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 575540000203 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 575540000204 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 575540000205 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 575540000206 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 575540000207 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 575540000208 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 575540000209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 575540000210 active site 575540000211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 575540000212 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 575540000213 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 575540000214 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 575540000215 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 575540000216 TilS substrate C-terminal domain; Region: TilS_C; smart00977 575540000217 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 575540000218 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 575540000219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 575540000220 ligand binding site [chemical binding]; other site 575540000221 flexible hinge region; other site 575540000222 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 575540000223 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 575540000224 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 575540000225 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 575540000226 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540000227 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 575540000228 active site 575540000229 metal binding site [ion binding]; metal-binding site 575540000230 YacP-like NYN domain; Region: NYN_YacP; cl01491 575540000231 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 575540000232 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 575540000233 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 575540000234 glutamine synthetase, type I; Region: GlnA; TIGR00653 575540000235 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 575540000236 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 575540000237 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540000238 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 575540000239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540000240 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 575540000241 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 575540000242 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 575540000243 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000244 active site 575540000245 ATP binding site [chemical binding]; other site 575540000246 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540000247 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000248 substrate binding site [chemical binding]; other site 575540000249 activation loop (A-loop); other site 575540000250 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540000251 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540000252 structural tetrad; other site 575540000253 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540000254 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540000255 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 575540000256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540000257 DNA binding residues [nucleotide binding] 575540000258 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 575540000259 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 575540000260 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 575540000261 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 575540000262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540000263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000264 binding surface 575540000265 TPR motif; other site 575540000266 TPR repeat; Region: TPR_11; pfam13414 575540000267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000268 TPR motif; other site 575540000269 binding surface 575540000270 TPR repeat; Region: TPR_11; pfam13414 575540000271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000272 binding surface 575540000273 TPR motif; other site 575540000274 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 575540000275 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 575540000276 nucleotide binding site [chemical binding]; other site 575540000277 putative NEF/HSP70 interaction site [polypeptide binding]; other site 575540000278 SBD interface [polypeptide binding]; other site 575540000279 CAAX protease self-immunity; Region: Abi; pfam02517 575540000280 AhpC/TSA family; Region: AhpC-TSA; pfam00578 575540000281 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 575540000282 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540000283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540000284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540000285 dimerization interface [polypeptide binding]; other site 575540000286 putative DNA binding site [nucleotide binding]; other site 575540000287 putative Zn2+ binding site [ion binding]; other site 575540000288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540000289 dimerization interface [polypeptide binding]; other site 575540000290 putative DNA binding site [nucleotide binding]; other site 575540000291 putative Zn2+ binding site [ion binding]; other site 575540000292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540000293 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 575540000294 DNA binding residues [nucleotide binding] 575540000295 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 575540000296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540000297 Walker A motif; other site 575540000298 ATP binding site [chemical binding]; other site 575540000299 Walker B motif; other site 575540000300 arginine finger; other site 575540000301 Peptidase family M41; Region: Peptidase_M41; pfam01434 575540000302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 575540000303 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 575540000304 substrate binding site [chemical binding]; other site 575540000305 ATP binding site [chemical binding]; other site 575540000306 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 575540000307 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 575540000308 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 575540000309 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 575540000310 active site 575540000311 substrate binding site [chemical binding]; other site 575540000312 metal binding site [ion binding]; metal-binding site 575540000313 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 575540000314 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 575540000315 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 575540000316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540000317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540000318 NAD(P) binding site [chemical binding]; other site 575540000319 active site 575540000320 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 575540000321 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000322 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540000323 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 575540000324 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 575540000325 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 575540000326 catalytic residues [active] 575540000327 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 575540000328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540000329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540000330 phosphopeptide binding site; other site 575540000331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 575540000332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 575540000333 metal binding site [ion binding]; metal-binding site 575540000334 active site 575540000335 I-site; other site 575540000336 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540000337 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 575540000338 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 575540000339 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 575540000340 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 575540000341 homodimer interface [polypeptide binding]; other site 575540000342 NADP binding site [chemical binding]; other site 575540000343 substrate binding site [chemical binding]; other site 575540000344 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540000345 anti sigma factor interaction site; other site 575540000346 regulatory phosphorylation site [posttranslational modification]; other site 575540000347 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 575540000348 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 575540000349 active site 575540000350 catalytic residues [active] 575540000351 metal binding site [ion binding]; metal-binding site 575540000352 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 575540000353 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 575540000354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 575540000355 active site 575540000356 HIGH motif; other site 575540000357 nucleotide binding site [chemical binding]; other site 575540000358 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 575540000359 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 575540000360 active site 575540000361 KMSKS motif; other site 575540000362 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 575540000363 tRNA binding surface [nucleotide binding]; other site 575540000364 anticodon binding site; other site 575540000365 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 575540000366 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 575540000367 dimer interface [polypeptide binding]; other site 575540000368 ADP-ribose binding site [chemical binding]; other site 575540000369 active site 575540000370 nudix motif; other site 575540000371 metal binding site [ion binding]; metal-binding site 575540000372 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000373 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540000374 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000375 substrate binding site [chemical binding]; other site 575540000376 activation loop (A-loop); other site 575540000377 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540000378 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540000379 structural tetrad; other site 575540000380 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540000381 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540000382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540000383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540000384 DNA binding residues [nucleotide binding] 575540000385 Cell differentiation family, Rcd1-like; Region: Rcd1; cl02160 575540000386 S-adenosylmethionine synthetase; Validated; Region: PRK05250 575540000387 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 575540000388 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 575540000389 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 575540000390 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 575540000391 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 575540000392 Sulfatase; Region: Sulfatase; cl17466 575540000393 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540000394 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 575540000395 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 575540000396 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 575540000397 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 575540000398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 575540000399 RPB11 interaction site [polypeptide binding]; other site 575540000400 RPB12 interaction site [polypeptide binding]; other site 575540000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 575540000402 RPB3 interaction site [polypeptide binding]; other site 575540000403 RPB1 interaction site [polypeptide binding]; other site 575540000404 RPB11 interaction site [polypeptide binding]; other site 575540000405 RPB10 interaction site [polypeptide binding]; other site 575540000406 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 575540000407 peripheral dimer interface [polypeptide binding]; other site 575540000408 core dimer interface [polypeptide binding]; other site 575540000409 L10 interface [polypeptide binding]; other site 575540000410 L11 interface [polypeptide binding]; other site 575540000411 putative EF-Tu interaction site [polypeptide binding]; other site 575540000412 putative EF-G interaction site [polypeptide binding]; other site 575540000413 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 575540000414 23S rRNA interface [nucleotide binding]; other site 575540000415 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 575540000416 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 575540000417 mRNA/rRNA interface [nucleotide binding]; other site 575540000418 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 575540000419 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 575540000420 23S rRNA interface [nucleotide binding]; other site 575540000421 L7/L12 interface [polypeptide binding]; other site 575540000422 putative thiostrepton binding site; other site 575540000423 L25 interface [polypeptide binding]; other site 575540000424 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 575540000425 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 575540000426 putative homodimer interface [polypeptide binding]; other site 575540000427 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 575540000428 heterodimer interface [polypeptide binding]; other site 575540000429 homodimer interface [polypeptide binding]; other site 575540000430 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 575540000431 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 575540000432 elongation factor Tu; Reviewed; Region: PRK12735 575540000433 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 575540000434 G1 box; other site 575540000435 GEF interaction site [polypeptide binding]; other site 575540000436 GTP/Mg2+ binding site [chemical binding]; other site 575540000437 Switch I region; other site 575540000438 G2 box; other site 575540000439 G3 box; other site 575540000440 Switch II region; other site 575540000441 G4 box; other site 575540000442 G5 box; other site 575540000443 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 575540000444 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 575540000445 Antibiotic Binding Site [chemical binding]; other site 575540000446 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540000447 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540000448 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540000449 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 575540000450 TadE-like protein; Region: TadE; pfam07811 575540000451 TadE-like protein; Region: TadE; pfam07811 575540000452 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 575540000453 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 575540000454 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540000455 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 575540000456 Walker A/P-loop; other site 575540000457 ATP binding site [chemical binding]; other site 575540000458 Q-loop/lid; other site 575540000459 ABC transporter signature motif; other site 575540000460 Walker B; other site 575540000461 D-loop; other site 575540000462 H-loop/switch region; other site 575540000463 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 575540000464 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 575540000465 carboxylate-amine ligase; Provisional; Region: PRK13517 575540000466 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 575540000467 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 575540000468 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 575540000469 metal binding site [ion binding]; metal-binding site 575540000470 dimer interface [polypeptide binding]; other site 575540000471 Proline dehydrogenase; Region: Pro_dh; cl03282 575540000472 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 575540000473 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 575540000474 Glutamate binding site [chemical binding]; other site 575540000475 homodimer interface [polypeptide binding]; other site 575540000476 NAD binding site [chemical binding]; other site 575540000477 catalytic residues [active] 575540000478 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540000479 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540000480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000481 TPR motif; other site 575540000482 binding surface 575540000483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000484 binding surface 575540000485 TPR motif; other site 575540000486 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540000487 AhpC/TSA family; Region: AhpC-TSA; pfam00578 575540000488 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540000489 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 575540000490 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 575540000491 hinge; other site 575540000492 active site 575540000493 hypothetical protein; Reviewed; Region: PRK12497 575540000494 KpsF/GutQ family protein; Region: kpsF; TIGR00393 575540000495 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 575540000496 putative active site [active] 575540000497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 575540000498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 575540000499 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 575540000500 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 575540000501 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 575540000502 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 575540000503 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 575540000504 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 575540000505 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 575540000506 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 575540000507 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 575540000508 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 575540000509 ATP binding site [chemical binding]; other site 575540000510 Walker A motif; other site 575540000511 hexamer interface [polypeptide binding]; other site 575540000512 Walker B motif; other site 575540000513 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 575540000514 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540000515 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 575540000516 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540000517 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 575540000518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540000519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540000520 DNA binding residues [nucleotide binding] 575540000521 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540000522 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540000523 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540000524 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 575540000525 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540000526 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 575540000527 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 575540000528 dimerization interface 3.5A [polypeptide binding]; other site 575540000529 active site 575540000530 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 575540000531 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 575540000532 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 575540000533 ABC1 family; Region: ABC1; cl17513 575540000534 ABC1 family; Region: ABC1; cl17513 575540000535 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 575540000536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540000537 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 575540000538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540000539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540000540 active site 575540000541 ATP binding site [chemical binding]; other site 575540000542 substrate binding site [chemical binding]; other site 575540000543 activation loop (A-loop); other site 575540000544 EVE domain; Region: EVE; cl00728 575540000545 Predicted membrane protein [Function unknown]; Region: COG2246 575540000546 GtrA-like protein; Region: GtrA; pfam04138 575540000547 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 575540000548 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 575540000549 Ligand Binding Site [chemical binding]; other site 575540000550 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 575540000551 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 575540000552 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 575540000553 ligand binding site [chemical binding]; other site 575540000554 NAD binding site [chemical binding]; other site 575540000555 catalytic site [active] 575540000556 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 575540000557 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 575540000558 catalytic triad [active] 575540000559 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 575540000560 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 575540000561 active site 575540000562 HslU subunit interaction site [polypeptide binding]; other site 575540000563 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 575540000564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540000565 Walker A motif; other site 575540000566 ATP binding site [chemical binding]; other site 575540000567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 575540000568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 575540000569 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540000570 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 575540000571 B3/4 domain; Region: B3_4; pfam03483 575540000572 tRNA synthetase B5 domain; Region: B5; smart00874 575540000573 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 575540000574 dimer interface [polypeptide binding]; other site 575540000575 motif 1; other site 575540000576 motif 3; other site 575540000577 motif 2; other site 575540000578 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 575540000579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540000580 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 575540000581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 575540000582 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 575540000583 active site 575540000584 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540000585 Sulfatase; Region: Sulfatase; pfam00884 575540000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540000587 S-adenosylmethionine binding site [chemical binding]; other site 575540000588 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 575540000589 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 575540000590 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 575540000591 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 575540000592 active site 575540000593 catalytic triad [active] 575540000594 oxyanion hole [active] 575540000595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 575540000596 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 575540000597 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 575540000598 acyl-activating enzyme (AAE) consensus motif; other site 575540000599 AMP binding site [chemical binding]; other site 575540000600 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 575540000601 putative acyl-acceptor binding pocket; other site 575540000602 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540000603 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540000605 metal-dependent hydrolase; Provisional; Region: PRK13291 575540000606 DinB superfamily; Region: DinB_2; pfam12867 575540000607 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 575540000608 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 575540000609 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 575540000610 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 575540000611 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 575540000612 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 575540000613 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 575540000614 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 575540000615 ligand binding site [chemical binding]; other site 575540000616 NAD binding site [chemical binding]; other site 575540000617 dimerization interface [polypeptide binding]; other site 575540000618 catalytic site [active] 575540000619 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 575540000620 putative L-serine binding site [chemical binding]; other site 575540000621 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 575540000622 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 575540000623 generic binding surface II; other site 575540000624 generic binding surface I; other site 575540000625 HD domain; Region: HD_4; pfam13328 575540000626 serine/threonine protein kinase; Provisional; Region: PRK12274 575540000627 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 575540000628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540000629 Walker A/P-loop; other site 575540000630 ATP binding site [chemical binding]; other site 575540000631 Q-loop/lid; other site 575540000632 ABC transporter signature motif; other site 575540000633 Walker B; other site 575540000634 D-loop; other site 575540000635 H-loop/switch region; other site 575540000636 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 575540000637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540000638 FeS/SAM binding site; other site 575540000639 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540000640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540000641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540000642 DNA binding residues [nucleotide binding] 575540000643 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 575540000644 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 575540000645 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 575540000646 domain interfaces; other site 575540000647 active site 575540000648 hypothetical protein; Provisional; Region: PRK08912 575540000649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540000650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540000651 homodimer interface [polypeptide binding]; other site 575540000652 catalytic residue [active] 575540000653 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 575540000654 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540000655 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540000656 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540000657 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540000658 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540000659 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540000660 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540000661 Predicted esterase [General function prediction only]; Region: COG0400 575540000662 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 575540000663 NYN domain; Region: NYN; pfam01936 575540000664 putative metal binding site [ion binding]; other site 575540000665 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540000666 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540000667 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 575540000668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540000669 catalytic residue [active] 575540000670 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 575540000671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000672 binding surface 575540000673 TPR motif; other site 575540000674 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540000675 SEC-C motif; Region: SEC-C; pfam02810 575540000676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000677 TPR repeat; Region: TPR_11; pfam13414 575540000678 binding surface 575540000679 TPR motif; other site 575540000680 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 575540000681 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 575540000682 G1 box; other site 575540000683 GTP/Mg2+ binding site [chemical binding]; other site 575540000684 Switch I region; other site 575540000685 G2 box; other site 575540000686 Switch II region; other site 575540000687 G3 box; other site 575540000688 G4 box; other site 575540000689 G5 box; other site 575540000690 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 575540000691 G1 box; other site 575540000692 GTP/Mg2+ binding site [chemical binding]; other site 575540000693 Switch I region; other site 575540000694 G2 box; other site 575540000695 G3 box; other site 575540000696 Switch II region; other site 575540000697 G4 box; other site 575540000698 G5 box; other site 575540000699 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 575540000700 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 575540000701 tandem repeat interface [polypeptide binding]; other site 575540000702 oligomer interface [polypeptide binding]; other site 575540000703 active site residues [active] 575540000704 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 575540000705 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540000706 Walker A/P-loop; other site 575540000707 ATP binding site [chemical binding]; other site 575540000708 Q-loop/lid; other site 575540000709 ABC transporter signature motif; other site 575540000710 Walker B; other site 575540000711 D-loop; other site 575540000712 H-loop/switch region; other site 575540000713 HSP90 family protein; Provisional; Region: PRK14083 575540000714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540000715 ATP binding site [chemical binding]; other site 575540000716 Mg2+ binding site [ion binding]; other site 575540000717 G-X-G motif; other site 575540000718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540000719 putative active site [active] 575540000720 PAS fold; Region: PAS_3; pfam08447 575540000721 heme pocket [chemical binding]; other site 575540000722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540000723 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 575540000724 putative active site [active] 575540000725 heme pocket [chemical binding]; other site 575540000726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540000727 dimer interface [polypeptide binding]; other site 575540000728 phosphorylation site [posttranslational modification] 575540000729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540000730 ATP binding site [chemical binding]; other site 575540000731 Mg2+ binding site [ion binding]; other site 575540000732 G-X-G motif; other site 575540000733 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540000734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000735 active site 575540000736 phosphorylation site [posttranslational modification] 575540000737 Response regulator receiver domain; Region: Response_reg; pfam00072 575540000738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000739 active site 575540000740 phosphorylation site [posttranslational modification] 575540000741 intermolecular recognition site; other site 575540000742 dimerization interface [polypeptide binding]; other site 575540000743 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 575540000744 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 575540000745 SLBB domain; Region: SLBB; pfam10531 575540000746 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 575540000747 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540000748 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 575540000749 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 575540000750 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 575540000751 pteridine reductase; Provisional; Region: PRK09135 575540000752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540000753 NAD(P) binding site [chemical binding]; other site 575540000754 active site 575540000755 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 575540000756 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 575540000757 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000758 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000759 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000760 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540000761 DinB superfamily; Region: DinB_2; pfam12867 575540000762 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 575540000763 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540000764 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540000765 active site 575540000766 ATP binding site [chemical binding]; other site 575540000767 substrate binding site [chemical binding]; other site 575540000768 activation loop (A-loop); other site 575540000769 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 575540000770 catalytic motif [active] 575540000771 Catalytic residue [active] 575540000772 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540000773 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 575540000774 catalytic motif [active] 575540000775 Catalytic residue [active] 575540000776 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 575540000777 protein binding site [polypeptide binding]; other site 575540000778 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 575540000779 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 575540000780 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540000781 metal ion-dependent adhesion site (MIDAS); other site 575540000782 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 575540000783 putative ligand binding site [chemical binding]; other site 575540000784 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 575540000785 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540000786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000787 active site 575540000788 phosphorylation site [posttranslational modification] 575540000789 intermolecular recognition site; other site 575540000790 dimerization interface [polypeptide binding]; other site 575540000791 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540000792 methionine sulfoxide reductase A; Provisional; Region: PRK14054 575540000793 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 575540000794 D-ribose pyranase; Provisional; Region: PRK11797 575540000795 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 575540000796 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540000797 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 575540000798 active site 575540000799 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 575540000800 elongation factor P; Validated; Region: PRK00529 575540000801 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 575540000802 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 575540000803 RNA binding site [nucleotide binding]; other site 575540000804 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 575540000805 RNA binding site [nucleotide binding]; other site 575540000806 Cna protein B-type domain; Region: Cna_B; pfam05738 575540000807 Cna protein B-type domain; Region: Cna_B; pfam05738 575540000808 Cna protein B-type domain; Region: Cna_B; pfam05738 575540000809 Cna protein B-type domain; Region: Cna_B; pfam05738 575540000810 Right handed beta helix region; Region: Beta_helix; pfam13229 575540000811 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 575540000812 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 575540000813 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540000814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540000815 active site 575540000816 ATP binding site [chemical binding]; other site 575540000817 substrate binding site [chemical binding]; other site 575540000818 activation loop (A-loop); other site 575540000819 Helix-turn-helix domain; Region: HTH_17; pfam12728 575540000820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000821 binding surface 575540000822 TPR motif; other site 575540000823 TPR repeat; Region: TPR_11; pfam13414 575540000824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000825 binding surface 575540000826 TPR motif; other site 575540000827 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 575540000828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000829 binding surface 575540000830 TPR motif; other site 575540000831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000832 binding surface 575540000833 TPR motif; other site 575540000834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540000835 binding surface 575540000836 TPR motif; other site 575540000837 TPR repeat; Region: TPR_11; pfam13414 575540000838 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 575540000839 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 575540000840 catalytic residue [active] 575540000841 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 575540000842 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 575540000843 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 575540000844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540000845 Walker A motif; other site 575540000846 ATP binding site [chemical binding]; other site 575540000847 Walker B motif; other site 575540000848 arginine finger; other site 575540000849 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 575540000850 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 575540000851 HEAT repeats; Region: HEAT_2; pfam13646 575540000852 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 575540000853 DNA binding residues [nucleotide binding] 575540000854 Response regulator receiver domain; Region: Response_reg; pfam00072 575540000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000856 active site 575540000857 phosphorylation site [posttranslational modification] 575540000858 intermolecular recognition site; other site 575540000859 dimerization interface [polypeptide binding]; other site 575540000860 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 575540000861 trimer interface [polypeptide binding]; other site 575540000862 dimer interface [polypeptide binding]; other site 575540000863 putative active site [active] 575540000864 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 575540000865 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 575540000866 substrate binding pocket [chemical binding]; other site 575540000867 chain length determination region; other site 575540000868 substrate-Mg2+ binding site; other site 575540000869 catalytic residues [active] 575540000870 aspartate-rich region 1; other site 575540000871 active site lid residues [active] 575540000872 aspartate-rich region 2; other site 575540000873 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 575540000874 C-terminal peptidase (prc); Region: prc; TIGR00225 575540000875 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 575540000876 protein binding site [polypeptide binding]; other site 575540000877 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 575540000878 Catalytic dyad [active] 575540000879 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 575540000880 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 575540000881 putative [4Fe-4S] binding site [ion binding]; other site 575540000882 putative molybdopterin cofactor binding site [chemical binding]; other site 575540000883 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 575540000884 putative molybdopterin cofactor binding site; other site 575540000885 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 575540000886 purine nucleoside phosphorylase; Provisional; Region: PRK08202 575540000887 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 575540000888 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 575540000889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540000890 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 575540000891 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540000892 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 575540000893 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 575540000894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540000895 active site 575540000896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540000897 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540000898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 575540000899 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540000900 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540000901 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 575540000902 ketol-acid reductoisomerase; Provisional; Region: PRK05479 575540000903 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 575540000904 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 575540000905 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 575540000906 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 575540000907 putative valine binding site [chemical binding]; other site 575540000908 dimer interface [polypeptide binding]; other site 575540000909 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 575540000910 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 575540000911 Glucuronate isomerase; Region: UxaC; cl00829 575540000912 Uncharacterized conserved protein [Function unknown]; Region: COG3379 575540000913 Uncharacterized conserved protein [Function unknown]; Region: COG3379 575540000914 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540000915 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540000916 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 575540000917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 575540000918 active site 575540000919 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 575540000920 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 575540000921 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 575540000922 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 575540000923 Protein of unknown function, DUF486; Region: DUF486; cl01236 575540000924 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 575540000925 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 575540000926 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 575540000927 DsrE/DsrF-like family; Region: DrsE; pfam02635 575540000928 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540000929 Sulfatase; Region: Sulfatase; pfam00884 575540000930 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 575540000931 putative ADP-ribose binding site [chemical binding]; other site 575540000932 aspartate aminotransferase; Provisional; Region: PRK08636 575540000933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540000934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540000935 homodimer interface [polypeptide binding]; other site 575540000936 catalytic residue [active] 575540000937 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 575540000938 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 575540000939 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 575540000940 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 575540000941 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 575540000942 IHF dimer interface [polypeptide binding]; other site 575540000943 IHF - DNA interface [nucleotide binding]; other site 575540000944 Cupin domain; Region: Cupin_2; cl17218 575540000945 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540000946 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540000947 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 575540000948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 575540000949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540000950 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 575540000951 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540000952 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540000953 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540000954 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540000955 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 575540000956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540000957 putative catalytic residue [active] 575540000958 Haem-binding domain; Region: Haem_bd; pfam14376 575540000959 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 575540000960 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 575540000961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540000962 FeS/SAM binding site; other site 575540000963 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 575540000964 putative active site [active] 575540000965 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 575540000966 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 575540000967 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 575540000968 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 575540000969 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 575540000970 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 575540000971 trimer interface [polypeptide binding]; other site 575540000972 active site 575540000973 UDP-GlcNAc binding site [chemical binding]; other site 575540000974 lipid binding site [chemical binding]; lipid-binding site 575540000975 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 575540000976 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540000977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540000978 putative active site [active] 575540000979 heme pocket [chemical binding]; other site 575540000980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540000981 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 575540000982 putative active site [active] 575540000983 heme pocket [chemical binding]; other site 575540000984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540000985 dimer interface [polypeptide binding]; other site 575540000986 phosphorylation site [posttranslational modification] 575540000987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540000988 ATP binding site [chemical binding]; other site 575540000989 Mg2+ binding site [ion binding]; other site 575540000990 G-X-G motif; other site 575540000991 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540000992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540000993 active site 575540000994 phosphorylation site [posttranslational modification] 575540000995 intermolecular recognition site; other site 575540000996 dimerization interface [polypeptide binding]; other site 575540000997 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 575540000998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540000999 motif II; other site 575540001000 UGMP family protein; Validated; Region: PRK09604 575540001001 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 575540001002 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 575540001003 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 575540001004 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 575540001005 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 575540001006 active site 575540001007 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cl00249 575540001008 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 575540001009 trimer interface I [polypeptide binding]; other site 575540001010 putative substrate binding pocket [chemical binding]; other site 575540001011 trimer interface II [polypeptide binding]; other site 575540001012 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 575540001013 domain_subunit interface; other site 575540001014 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 575540001015 putative acyl-acceptor binding pocket; other site 575540001016 acyl carrier protein; Provisional; Region: acpP; PRK00982 575540001017 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540001018 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540001019 dimer interface [polypeptide binding]; other site 575540001020 active site 575540001021 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 575540001022 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 575540001023 trimer interface [polypeptide binding]; other site 575540001024 active site 575540001025 substrate binding site [chemical binding]; other site 575540001026 CoA binding site [chemical binding]; other site 575540001027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 575540001028 hypothetical protein; Validated; Region: PRK07080 575540001029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 575540001030 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540001031 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540001032 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540001033 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540001034 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 575540001035 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540001036 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540001037 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540001038 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 575540001039 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 575540001040 active site 575540001041 substrate binding site [chemical binding]; other site 575540001042 cosubstrate binding site; other site 575540001043 catalytic site [active] 575540001044 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 575540001045 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 575540001046 active site 575540001047 HIGH motif; other site 575540001048 nucleotide binding site [chemical binding]; other site 575540001049 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 575540001050 active site 575540001051 KMSKS motif; other site 575540001052 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 575540001053 tRNA binding surface [nucleotide binding]; other site 575540001054 anticodon binding site; other site 575540001055 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 575540001056 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 575540001057 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 575540001058 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540001059 Outer membrane efflux protein; Region: OEP; pfam02321 575540001060 Outer membrane efflux protein; Region: OEP; pfam02321 575540001061 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 575540001062 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540001063 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 575540001064 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 575540001065 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 575540001066 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 575540001067 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 575540001068 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 575540001069 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 575540001070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540001071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540001072 homodimer interface [polypeptide binding]; other site 575540001073 catalytic residue [active] 575540001074 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 575540001075 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 575540001076 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 575540001077 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 575540001078 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 575540001079 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540001080 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540001081 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 575540001082 substrate binding site [chemical binding]; other site 575540001083 THF binding site; other site 575540001084 zinc-binding site [ion binding]; other site 575540001085 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 575540001086 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 575540001087 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 575540001088 D-xylulose kinase; Region: XylB; TIGR01312 575540001089 N- and C-terminal domain interface [polypeptide binding]; other site 575540001090 active site 575540001091 MgATP binding site [chemical binding]; other site 575540001092 catalytic site [active] 575540001093 metal binding site [ion binding]; metal-binding site 575540001094 xylulose binding site [chemical binding]; other site 575540001095 homodimer interface [polypeptide binding]; other site 575540001096 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 575540001097 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 575540001098 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 575540001099 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 575540001100 Ligand binding site; other site 575540001101 Putative Catalytic site; other site 575540001102 DXD motif; other site 575540001103 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 575540001104 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 575540001105 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 575540001106 Sulfate transporter family; Region: Sulfate_transp; pfam00916 575540001107 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 575540001108 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 575540001109 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 575540001110 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 575540001111 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 575540001112 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 575540001113 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 575540001114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540001115 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 575540001116 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 575540001117 NADH dehydrogenase; Region: NADHdh; cl00469 575540001118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540001119 Helix-turn-helix domain; Region: HTH_17; pfam12728 575540001120 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 575540001121 active site 575540001122 phosphorylation site [posttranslational modification] 575540001123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540001124 dimerization interface [polypeptide binding]; other site 575540001125 putative DNA binding site [nucleotide binding]; other site 575540001126 putative Zn2+ binding site [ion binding]; other site 575540001127 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540001128 anti sigma factor interaction site; other site 575540001129 regulatory phosphorylation site [posttranslational modification]; other site 575540001130 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 575540001131 MutS domain I; Region: MutS_I; pfam01624 575540001132 MutS domain II; Region: MutS_II; pfam05188 575540001133 MutS domain III; Region: MutS_III; pfam05192 575540001134 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 575540001135 Walker A/P-loop; other site 575540001136 ATP binding site [chemical binding]; other site 575540001137 Q-loop/lid; other site 575540001138 ABC transporter signature motif; other site 575540001139 Walker B; other site 575540001140 D-loop; other site 575540001141 H-loop/switch region; other site 575540001142 Family description; Region: VCBS; pfam13517 575540001143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540001144 TPR motif; other site 575540001145 TPR repeat; Region: TPR_11; pfam13414 575540001146 binding surface 575540001147 TPR repeat; Region: TPR_11; pfam13414 575540001148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540001149 binding surface 575540001150 TPR motif; other site 575540001151 TPR repeat; Region: TPR_11; pfam13414 575540001152 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540001153 Transcription factor subunit Med10 of Mediator complex; Region: Med10; pfam09748 575540001154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540001155 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 575540001156 putative NAD(P) binding site [chemical binding]; other site 575540001157 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 575540001158 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 575540001159 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 575540001160 Substrate binding site; other site 575540001161 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 575540001162 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 575540001163 substrate binding site; other site 575540001164 dimerization interface; other site 575540001165 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 575540001166 putative hydrolase; Provisional; Region: PRK02113 575540001167 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 575540001168 DNA methylase; Region: N6_N4_Mtase; cl17433 575540001169 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 575540001170 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001171 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001172 Leucine-rich repeats; other site 575540001173 Substrate binding site [chemical binding]; other site 575540001174 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001175 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 575540001176 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001177 Leucine-rich repeats; other site 575540001178 Substrate binding site [chemical binding]; other site 575540001179 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001180 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001181 Leucine-rich repeats; other site 575540001182 Substrate binding site [chemical binding]; other site 575540001183 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001184 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001185 Substrate binding site [chemical binding]; other site 575540001186 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 575540001187 Low-spin heme binding site [chemical binding]; other site 575540001188 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 575540001189 D-pathway; other site 575540001190 Putative water exit pathway; other site 575540001191 Binuclear center (active site) [active] 575540001192 K-pathway; other site 575540001193 Putative proton exit pathway; other site 575540001194 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 575540001195 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 575540001196 Cytochrome c; Region: Cytochrom_C; pfam00034 575540001197 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 575540001198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540001199 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540001200 Bacterial Ig-like domain; Region: Big_5; pfam13205 575540001201 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 575540001202 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 575540001203 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 575540001204 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 575540001205 putative homodimer interface [polypeptide binding]; other site 575540001206 putative homotetramer interface [polypeptide binding]; other site 575540001207 putative allosteric switch controlling residues; other site 575540001208 putative metal binding site [ion binding]; other site 575540001209 putative homodimer-homodimer interface [polypeptide binding]; other site 575540001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540001211 dimer interface [polypeptide binding]; other site 575540001212 conserved gate region; other site 575540001213 putative PBP binding loops; other site 575540001214 ABC-ATPase subunit interface; other site 575540001215 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 575540001216 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 575540001217 Walker A/P-loop; other site 575540001218 ATP binding site [chemical binding]; other site 575540001219 Q-loop/lid; other site 575540001220 ABC transporter signature motif; other site 575540001221 Walker B; other site 575540001222 D-loop; other site 575540001223 H-loop/switch region; other site 575540001224 PBP superfamily domain; Region: PBP_like_2; pfam12849 575540001225 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 575540001226 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 575540001227 nucleotide binding site [chemical binding]; other site 575540001228 substrate binding site [chemical binding]; other site 575540001229 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 575540001230 nucleotide binding site [chemical binding]; other site 575540001231 substrate binding site [chemical binding]; other site 575540001232 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540001233 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540001234 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 575540001235 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 575540001236 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540001237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001238 Walker A motif; other site 575540001239 ATP binding site [chemical binding]; other site 575540001240 Walker B motif; other site 575540001241 arginine finger; other site 575540001242 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 575540001243 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540001244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540001245 metal ion-dependent adhesion site (MIDAS); other site 575540001246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540001247 metal ion-dependent adhesion site (MIDAS); other site 575540001248 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540001249 metal ion-dependent adhesion site (MIDAS); other site 575540001250 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 575540001251 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 575540001252 E3 interaction surface; other site 575540001253 lipoyl attachment site [posttranslational modification]; other site 575540001254 e3 binding domain; Region: E3_binding; pfam02817 575540001255 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 575540001256 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 575540001257 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 575540001258 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 575540001259 PYR/PP interface [polypeptide binding]; other site 575540001260 dimer interface [polypeptide binding]; other site 575540001261 TPP binding site [chemical binding]; other site 575540001262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 575540001263 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 575540001264 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 575540001265 tetramer interface [polypeptide binding]; other site 575540001266 TPP-binding site [chemical binding]; other site 575540001267 heterodimer interface [polypeptide binding]; other site 575540001268 phosphorylation loop region [posttranslational modification] 575540001269 FOG: WD40-like repeat [Function unknown]; Region: COG1520 575540001270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001271 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540001272 Walker A motif; other site 575540001273 ATP binding site [chemical binding]; other site 575540001274 Walker B motif; other site 575540001275 arginine finger; other site 575540001276 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 575540001277 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 575540001278 NAD binding site [chemical binding]; other site 575540001279 substrate binding site [chemical binding]; other site 575540001280 catalytic Zn binding site [ion binding]; other site 575540001281 tetramer interface [polypeptide binding]; other site 575540001282 structural Zn binding site [ion binding]; other site 575540001283 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 575540001284 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 575540001285 NAD(P) binding site [chemical binding]; other site 575540001286 catalytic residues [active] 575540001287 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 575540001288 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 575540001289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001290 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 575540001291 Walker A motif; other site 575540001292 ATP binding site [chemical binding]; other site 575540001293 Walker B motif; other site 575540001294 arginine finger; other site 575540001295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001296 Walker A motif; other site 575540001297 ATP binding site [chemical binding]; other site 575540001298 Walker B motif; other site 575540001299 arginine finger; other site 575540001300 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 575540001301 putative dimer interface [polypeptide binding]; other site 575540001302 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540001304 active site 575540001305 phosphorylation site [posttranslational modification] 575540001306 intermolecular recognition site; other site 575540001307 dimerization interface [polypeptide binding]; other site 575540001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001309 Walker A motif; other site 575540001310 ATP binding site [chemical binding]; other site 575540001311 Walker B motif; other site 575540001312 arginine finger; other site 575540001313 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540001314 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 575540001315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 575540001316 metal-binding site [ion binding] 575540001317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540001318 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540001319 Sulfatase; Region: Sulfatase; pfam00884 575540001320 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540001321 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 575540001322 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540001323 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 575540001324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540001325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540001326 DNA binding residues [nucleotide binding] 575540001327 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540001328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540001329 phosphopeptide binding site; other site 575540001330 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540001331 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540001332 active site 575540001333 ATP binding site [chemical binding]; other site 575540001334 substrate binding site [chemical binding]; other site 575540001335 activation loop (A-loop); other site 575540001336 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 575540001337 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 575540001338 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 575540001339 putative Iron-sulfur protein interface [polypeptide binding]; other site 575540001340 proximal heme binding site [chemical binding]; other site 575540001341 putative dimer interface [polypeptide binding]; other site 575540001342 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 575540001343 distal heme binding site [chemical binding]; other site 575540001344 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 575540001345 L-aspartate oxidase; Provisional; Region: PRK06175 575540001346 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 575540001347 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 575540001348 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 575540001349 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 575540001350 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 575540001351 Global regulator protein family; Region: CsrA; cl00670 575540001352 FliW protein; Region: FliW; cl00740 575540001353 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540001354 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 575540001355 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 575540001356 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 575540001357 active site 575540001358 catalytic site [active] 575540001359 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 575540001360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540001361 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540001362 putative phosphate acyltransferase; Provisional; Region: PRK05331 575540001363 [acyl-carrier protein] S-malonyltransferase; Region: PLN02752 575540001364 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 575540001365 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 575540001366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540001367 NAD(P) binding site [chemical binding]; other site 575540001368 active site 575540001369 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540001370 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 575540001371 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 575540001372 homodimer interface [polypeptide binding]; other site 575540001373 substrate-cofactor binding pocket; other site 575540001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540001375 catalytic residue [active] 575540001376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 575540001377 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001378 catalytic residues [active] 575540001379 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 575540001380 active site 575540001381 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 575540001382 Peptidase family U32; Region: Peptidase_U32; pfam01136 575540001383 Collagenase; Region: DUF3656; pfam12392 575540001384 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 575540001385 Peptidase family U32; Region: Peptidase_U32; cl03113 575540001386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540001387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540001388 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 575540001389 putative active site [active] 575540001390 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 575540001391 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 575540001392 Predicted permease; Region: DUF318; cl17795 575540001393 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 575540001394 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 575540001395 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 575540001396 putative trimer interface [polypeptide binding]; other site 575540001397 putative CoA binding site [chemical binding]; other site 575540001398 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 575540001399 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 575540001400 glutaminase active site [active] 575540001401 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 575540001402 dimer interface [polypeptide binding]; other site 575540001403 active site 575540001404 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 575540001405 dimer interface [polypeptide binding]; other site 575540001406 active site 575540001407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540001408 active site 575540001409 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001411 S-adenosylmethionine binding site [chemical binding]; other site 575540001412 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 575540001413 Flavoprotein; Region: Flavoprotein; pfam02441 575540001414 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 575540001415 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 575540001416 dimer interface [polypeptide binding]; other site 575540001417 motif 1; other site 575540001418 motif 2; other site 575540001419 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540001420 motif 3; other site 575540001421 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 575540001422 anticodon binding site; other site 575540001423 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 575540001424 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 575540001425 dimer interface [polypeptide binding]; other site 575540001426 motif 1; other site 575540001427 motif 2; other site 575540001428 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540001429 active site 575540001430 motif 3; other site 575540001431 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 575540001432 ATP phosphoribosyltransferase; Region: HisG; cl15266 575540001433 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001435 S-adenosylmethionine binding site [chemical binding]; other site 575540001436 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 575540001437 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 575540001438 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 575540001439 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 575540001440 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 575540001441 23S rRNA binding site [nucleotide binding]; other site 575540001442 L21 binding site [polypeptide binding]; other site 575540001443 L13 binding site [polypeptide binding]; other site 575540001444 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 575540001445 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 575540001446 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 575540001447 dimer interface [polypeptide binding]; other site 575540001448 motif 1; other site 575540001449 active site 575540001450 motif 2; other site 575540001451 motif 3; other site 575540001452 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 575540001453 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 575540001454 putative acyl-acceptor binding pocket; other site 575540001455 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001456 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001457 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 575540001458 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 575540001459 dimerization interface [polypeptide binding]; other site 575540001460 DPS ferroxidase diiron center [ion binding]; other site 575540001461 ion pore; other site 575540001462 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 575540001463 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 575540001464 active site 575540001465 Zn binding site [ion binding]; other site 575540001466 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 575540001467 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 575540001468 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 575540001469 catalytic triad [active] 575540001470 conserved cis-peptide bond; other site 575540001471 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 575540001472 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540001473 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 575540001474 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540001475 metal ion-dependent adhesion site (MIDAS); other site 575540001476 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540001477 phosphopeptide binding site; other site 575540001478 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 575540001479 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 575540001480 [2Fe-2S] cluster binding site [ion binding]; other site 575540001481 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 575540001482 putative alpha subunit interface [polypeptide binding]; other site 575540001483 putative active site [active] 575540001484 putative substrate binding site [chemical binding]; other site 575540001485 Fe binding site [ion binding]; other site 575540001486 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 575540001487 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 575540001488 catalytic residues [active] 575540001489 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 575540001490 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 575540001491 active site 575540001492 trimer interface [polypeptide binding]; other site 575540001493 allosteric site; other site 575540001494 active site lid [active] 575540001495 hexamer (dimer of trimers) interface [polypeptide binding]; other site 575540001496 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 575540001497 putative active site [active] 575540001498 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540001499 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540001500 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540001501 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 575540001502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540001503 RNA binding surface [nucleotide binding]; other site 575540001504 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 575540001505 active site 575540001506 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 575540001507 active site 575540001508 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 575540001509 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540001510 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 575540001511 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540001512 active site 575540001513 ATP binding site [chemical binding]; other site 575540001514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540001515 substrate binding site [chemical binding]; other site 575540001516 activation loop (A-loop); other site 575540001517 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 575540001518 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 575540001519 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 575540001520 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540001521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540001522 NAD(P) binding site [chemical binding]; other site 575540001523 active site 575540001524 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001525 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001526 Leucine-rich repeats; other site 575540001527 Substrate binding site [chemical binding]; other site 575540001528 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 575540001529 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 575540001530 active site 575540001531 dimer interface [polypeptide binding]; other site 575540001532 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 575540001533 Ligand Binding Site [chemical binding]; other site 575540001534 Molecular Tunnel; other site 575540001535 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 575540001536 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 575540001537 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 575540001538 metal binding site [ion binding]; metal-binding site 575540001539 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 575540001540 substrate binding pocket [chemical binding]; other site 575540001541 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 575540001542 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 575540001543 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 575540001544 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 575540001545 Penicillinase repressor; Region: Pencillinase_R; cl17580 575540001546 Bifunctional nuclease; Region: DNase-RNase; pfam02577 575540001547 GH3 auxin-responsive promoter; Region: GH3; pfam03321 575540001548 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 575540001549 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540001550 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540001551 dimer interface [polypeptide binding]; other site 575540001552 active site 575540001553 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540001554 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540001555 dimer interface [polypeptide binding]; other site 575540001556 active site 575540001557 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 575540001558 active site 2 [active] 575540001559 active site 1 [active] 575540001560 acyl carrier protein; Provisional; Region: acpP; PRK00982 575540001561 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 575540001562 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 575540001563 translocation protein TolB; Provisional; Region: tolB; PRK00178 575540001564 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 575540001565 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 575540001566 FTR, proximal lobe; Region: FTR_C; pfam02741 575540001567 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 575540001568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540001569 active site 575540001570 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 575540001571 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 575540001572 purine monophosphate binding site [chemical binding]; other site 575540001573 dimer interface [polypeptide binding]; other site 575540001574 putative catalytic residues [active] 575540001575 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 575540001576 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 575540001577 classical (c) SDRs; Region: SDR_c; cd05233 575540001578 NAD(P) binding site [chemical binding]; other site 575540001579 active site 575540001580 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 575540001581 active site 575540001582 catalytic residues [active] 575540001583 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 575540001584 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 575540001585 Ligand binding site; other site 575540001586 oligomer interface; other site 575540001587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540001588 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 575540001589 putative ADP-binding pocket [chemical binding]; other site 575540001590 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 575540001591 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 575540001592 active site 575540001593 dimerization interface [polypeptide binding]; other site 575540001594 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 575540001595 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 575540001596 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 575540001597 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540001598 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540001599 Substrate binding site [chemical binding]; other site 575540001600 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540001601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001602 Walker A motif; other site 575540001603 ATP binding site [chemical binding]; other site 575540001604 Walker B motif; other site 575540001605 arginine finger; other site 575540001606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540001608 Walker A motif; other site 575540001609 ATP binding site [chemical binding]; other site 575540001610 Walker B motif; other site 575540001611 arginine finger; other site 575540001612 Peptidase family M41; Region: Peptidase_M41; pfam01434 575540001613 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 575540001614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540001615 PAS domain; Region: PAS_9; pfam13426 575540001616 putative active site [active] 575540001617 heme pocket [chemical binding]; other site 575540001618 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 575540001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001620 Walker A motif; other site 575540001621 ATP binding site [chemical binding]; other site 575540001622 Walker B motif; other site 575540001623 arginine finger; other site 575540001624 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540001625 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 575540001626 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 575540001627 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 575540001628 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 575540001629 gamma subunit interface [polypeptide binding]; other site 575540001630 epsilon subunit interface [polypeptide binding]; other site 575540001631 LBP interface [polypeptide binding]; other site 575540001632 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 575540001633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 575540001634 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 575540001635 alpha subunit interaction interface [polypeptide binding]; other site 575540001636 Walker A motif; other site 575540001637 ATP binding site [chemical binding]; other site 575540001638 Walker B motif; other site 575540001639 inhibitor binding site; inhibition site 575540001640 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 575540001641 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 575540001642 core domain interface [polypeptide binding]; other site 575540001643 delta subunit interface [polypeptide binding]; other site 575540001644 epsilon subunit interface [polypeptide binding]; other site 575540001645 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 575540001646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 575540001647 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 575540001648 beta subunit interaction interface [polypeptide binding]; other site 575540001649 Walker A motif; other site 575540001650 ATP binding site [chemical binding]; other site 575540001651 Walker B motif; other site 575540001652 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 575540001653 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 575540001654 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 575540001655 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 575540001656 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 575540001657 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 575540001658 ATP synthase A chain; Region: ATP-synt_A; cl00413 575540001659 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 575540001660 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 575540001661 Cytochrome c; Region: Cytochrom_C; pfam00034 575540001662 Cytochrome c; Region: Cytochrom_C; pfam00034 575540001663 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 575540001664 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 575540001665 D-pathway; other site 575540001666 Low-spin heme binding site [chemical binding]; other site 575540001667 Putative water exit pathway; other site 575540001668 Binuclear center (active site) [active] 575540001669 K-pathway; other site 575540001670 Putative proton exit pathway; other site 575540001671 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 575540001672 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 575540001673 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540001674 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540001675 Family description; Region: DsbD_2; pfam13386 575540001676 Family description; Region: DsbD_2; pfam13386 575540001677 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 575540001678 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540001679 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540001680 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540001681 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540001682 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 575540001683 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 575540001684 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 575540001685 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 575540001686 putative active site; other site 575540001687 catalytic triad [active] 575540001688 putative dimer interface [polypeptide binding]; other site 575540001689 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 575540001690 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 575540001691 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 575540001692 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001693 putative catalytic residue [active] 575540001694 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540001695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001696 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540001697 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001698 catalytic residues [active] 575540001699 peptide chain release factor 1; Validated; Region: prfA; PRK00591 575540001700 PCRF domain; Region: PCRF; pfam03462 575540001701 RF-1 domain; Region: RF-1; pfam00472 575540001702 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 575540001703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001704 S-adenosylmethionine binding site [chemical binding]; other site 575540001705 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 575540001706 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 575540001707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001708 Walker A motif; other site 575540001709 ATP binding site [chemical binding]; other site 575540001710 Walker B motif; other site 575540001711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 575540001712 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540001713 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 575540001714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540001715 catalytic residue [active] 575540001716 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 575540001717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540001718 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 575540001719 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 575540001720 aspartate kinase; Provisional; Region: PRK07431 575540001721 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 575540001722 putative catalytic residues [active] 575540001723 putative nucleotide binding site [chemical binding]; other site 575540001724 putative aspartate binding site [chemical binding]; other site 575540001725 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 575540001726 putative allosteric regulatory site; other site 575540001727 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 575540001728 putative allosteric regulatory residue; other site 575540001729 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 575540001730 putative allosteric regulatory site; other site 575540001731 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 575540001732 putative allosteric regulatory residue; other site 575540001733 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 575540001734 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 575540001735 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 575540001736 aspartate aminotransferase; Provisional; Region: PRK05764 575540001737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540001738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540001739 homodimer interface [polypeptide binding]; other site 575540001740 catalytic residue [active] 575540001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001742 S-adenosylmethionine binding site [chemical binding]; other site 575540001743 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 575540001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001745 S-adenosylmethionine binding site [chemical binding]; other site 575540001746 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 575540001747 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 575540001748 putative active site [active] 575540001749 putative metal binding site [ion binding]; other site 575540001750 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540001751 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540001752 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540001753 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 575540001754 Uncharacterized conserved protein [Function unknown]; Region: COG2006 575540001755 Domain of unknown function (DUF362); Region: DUF362; pfam04015 575540001756 Domain of unknown function (DUF362); Region: DUF362; pfam04015 575540001757 Uncharacterized conserved protein [Function unknown]; Region: COG2006 575540001758 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 575540001759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 575540001760 active site 575540001761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540001762 Domain of unknown function (DUF336); Region: DUF336; cl01249 575540001763 hypothetical protein; Provisional; Region: PRK09256 575540001764 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540001765 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 575540001766 catalytic site [active] 575540001767 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540001768 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540001769 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 575540001770 active site 575540001771 Zn binding site [ion binding]; other site 575540001772 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 575540001773 Zn binding site [ion binding]; other site 575540001774 Surface antigen; Region: Bac_surface_Ag; pfam01103 575540001775 pyruvate carboxylase; Reviewed; Region: PRK12999 575540001776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 575540001777 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540001778 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 575540001779 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 575540001780 active site 575540001781 catalytic residues [active] 575540001782 metal binding site [ion binding]; metal-binding site 575540001783 homodimer binding site [polypeptide binding]; other site 575540001784 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 575540001785 carboxyltransferase (CT) interaction site; other site 575540001786 biotinylation site [posttranslational modification]; other site 575540001787 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540001788 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001789 catalytic residues [active] 575540001790 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 575540001791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 575540001792 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 575540001793 Probable Catalytic site; other site 575540001794 metal-binding site 575540001795 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540001796 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001797 catalytic residues [active] 575540001798 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540001799 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001800 catalytic residues [active] 575540001801 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 575540001802 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540001803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540001804 protein binding site [polypeptide binding]; other site 575540001805 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540001806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540001807 catalytic residues [active] 575540001808 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 575540001809 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 575540001810 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540001811 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540001812 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540001813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540001814 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540001815 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 575540001816 Protein export membrane protein; Region: SecD_SecF; cl14618 575540001817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540001818 Walker A/P-loop; other site 575540001819 ATP binding site [chemical binding]; other site 575540001820 Q-loop/lid; other site 575540001821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540001822 ABC transporter signature motif; other site 575540001823 Walker B; other site 575540001824 D-loop; other site 575540001825 H-loop/switch region; other site 575540001826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540001827 Walker A/P-loop; other site 575540001828 ATP binding site [chemical binding]; other site 575540001829 Q-loop/lid; other site 575540001830 ABC transporter signature motif; other site 575540001831 Walker B; other site 575540001832 D-loop; other site 575540001833 H-loop/switch region; other site 575540001834 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 575540001835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 575540001836 putative acyl-acceptor binding pocket; other site 575540001837 cytidylate kinase; Provisional; Region: cmk; PRK00023 575540001838 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 575540001839 CMP-binding site; other site 575540001840 The sites determining sugar specificity; other site 575540001841 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 575540001842 Uncharacterized conserved protein [Function unknown]; Region: COG2006 575540001843 Domain of unknown function (DUF362); Region: DUF362; pfam04015 575540001844 4Fe-4S binding domain; Region: Fer4_5; pfam12801 575540001845 4Fe-4S binding domain; Region: Fer4_5; pfam12801 575540001846 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 575540001847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 575540001848 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 575540001849 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 575540001850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 575540001851 4Fe-4S binding domain; Region: Fer4; pfam00037 575540001852 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 575540001853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540001854 Walker A motif; other site 575540001855 ATP binding site [chemical binding]; other site 575540001856 Walker B motif; other site 575540001857 arginine finger; other site 575540001858 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 575540001859 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 575540001860 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 575540001861 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 575540001862 Walker A/P-loop; other site 575540001863 ATP binding site [chemical binding]; other site 575540001864 Q-loop/lid; other site 575540001865 ABC transporter signature motif; other site 575540001866 Walker B; other site 575540001867 D-loop; other site 575540001868 H-loop/switch region; other site 575540001869 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 575540001870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540001871 dimer interface [polypeptide binding]; other site 575540001872 conserved gate region; other site 575540001873 putative PBP binding loops; other site 575540001874 ABC-ATPase subunit interface; other site 575540001875 NMT1/THI5 like; Region: NMT1; pfam09084 575540001876 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 575540001877 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 575540001878 active site 575540001879 catalytic residue [active] 575540001880 dimer interface [polypeptide binding]; other site 575540001881 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 575540001882 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 575540001883 shikimate binding site; other site 575540001884 NAD(P) binding site [chemical binding]; other site 575540001885 shikimate kinase; Reviewed; Region: aroK; PRK00131 575540001886 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 575540001887 ADP binding site [chemical binding]; other site 575540001888 magnesium binding site [ion binding]; other site 575540001889 putative shikimate binding site; other site 575540001890 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 575540001891 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 575540001892 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 575540001893 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 575540001894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 575540001895 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 575540001896 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 575540001897 putative dimer interface [polypeptide binding]; other site 575540001898 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 575540001899 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 575540001900 putative dimer interface [polypeptide binding]; other site 575540001901 ornithine carbamoyltransferase; Provisional; Region: PRK00779 575540001902 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 575540001903 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 575540001904 acetylornithine aminotransferase; Provisional; Region: PRK02627 575540001905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 575540001906 inhibitor-cofactor binding pocket; inhibition site 575540001907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540001908 catalytic residue [active] 575540001909 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 575540001910 feedback inhibition sensing region; other site 575540001911 homohexameric interface [polypeptide binding]; other site 575540001912 nucleotide binding site [chemical binding]; other site 575540001913 N-acetyl-L-glutamate binding site [chemical binding]; other site 575540001914 ACT domain-containing protein [General function prediction only]; Region: COG4747 575540001915 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 575540001916 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 575540001917 nudix motif; other site 575540001918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 575540001919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 575540001920 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 575540001921 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 575540001922 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 575540001923 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 575540001924 tetramer interface [polypeptide binding]; other site 575540001925 active site 575540001926 Creatinine amidohydrolase; Region: Creatininase; pfam02633 575540001927 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 575540001928 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 575540001929 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 575540001930 Cu(I) binding site [ion binding]; other site 575540001931 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 575540001932 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 575540001933 NAD binding site [chemical binding]; other site 575540001934 ligand binding site [chemical binding]; other site 575540001935 catalytic site [active] 575540001936 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 575540001937 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 575540001938 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 575540001939 substrate binding pocket [chemical binding]; other site 575540001940 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 575540001941 B12 binding site [chemical binding]; other site 575540001942 cobalt ligand [ion binding]; other site 575540001943 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 575540001944 signal recognition particle protein; Provisional; Region: PRK10867 575540001945 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 575540001946 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 575540001947 P loop; other site 575540001948 GTP binding site [chemical binding]; other site 575540001949 Signal peptide binding domain; Region: SRP_SPB; pfam02978 575540001950 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 575540001951 NADH dehydrogenase subunit B; Validated; Region: PRK06411 575540001952 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 575540001953 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 575540001954 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 575540001955 NADH dehydrogenase subunit D; Validated; Region: PRK06075 575540001956 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 575540001957 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 575540001958 [2Fe-2S] cluster binding site [ion binding]; other site 575540001959 putative dimer interface [polypeptide binding]; other site 575540001960 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 575540001961 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 575540001962 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 575540001963 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 575540001964 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 575540001965 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 575540001966 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 575540001967 NAD(P) binding site [chemical binding]; other site 575540001968 catalytic residues [active] 575540001969 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 575540001970 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540001972 S-adenosylmethionine binding site [chemical binding]; other site 575540001973 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 575540001974 glyoxylate reductase; Reviewed; Region: PRK13243 575540001975 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 575540001976 dimerization interface [polypeptide binding]; other site 575540001977 ligand binding site [chemical binding]; other site 575540001978 NADP binding site [chemical binding]; other site 575540001979 catalytic site [active] 575540001980 homoserine dehydrogenase; Provisional; Region: PRK06349 575540001981 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 575540001982 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 575540001983 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 575540001984 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540001985 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 575540001986 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 575540001987 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 575540001988 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 575540001989 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540001990 motif 1; other site 575540001991 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 575540001992 active site 575540001993 motif 2; other site 575540001994 motif 3; other site 575540001995 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 575540001996 anticodon binding site; other site 575540001997 Response regulator receiver domain; Region: Response_reg; pfam00072 575540001998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540001999 active site 575540002000 phosphorylation site [posttranslational modification] 575540002001 intermolecular recognition site; other site 575540002002 dimerization interface [polypeptide binding]; other site 575540002003 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 575540002004 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 575540002005 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 575540002006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002007 ATP binding site [chemical binding]; other site 575540002008 Mg2+ binding site [ion binding]; other site 575540002009 G-X-G motif; other site 575540002010 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540002011 anti sigma factor interaction site; other site 575540002012 regulatory phosphorylation site [posttranslational modification]; other site 575540002013 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540002014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002015 Walker A motif; other site 575540002016 ATP binding site [chemical binding]; other site 575540002017 Walker B motif; other site 575540002018 arginine finger; other site 575540002019 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540002020 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 575540002021 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 575540002022 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 575540002023 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 575540002024 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540002025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540002026 ATP-dependent helicase; Provisional; Region: PRK13767 575540002027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540002028 ATP binding site [chemical binding]; other site 575540002029 putative Mg++ binding site [ion binding]; other site 575540002030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540002031 nucleotide binding region [chemical binding]; other site 575540002032 ATP-binding site [chemical binding]; other site 575540002033 DEAD/H associated; Region: DEAD_assoc; pfam08494 575540002034 sulfite oxidase; Provisional; Region: PLN00177 575540002035 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 575540002036 Moco binding site; other site 575540002037 metal coordination site [ion binding]; other site 575540002038 dimerization interface [polypeptide binding]; other site 575540002039 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540002040 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 575540002041 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 575540002042 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540002043 catalytic residues [active] 575540002044 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 575540002045 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540002046 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 575540002047 Nitrogen regulatory protein P-II; Region: P-II; smart00938 575540002048 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 575540002049 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 575540002050 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 575540002051 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 575540002052 putative active site [active] 575540002053 putative catalytic triad [active] 575540002054 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 575540002055 catalytic residues [active] 575540002056 CopC domain; Region: CopC; cl01012 575540002057 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 575540002058 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 575540002059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540002060 motif II; other site 575540002061 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 575540002062 Clp amino terminal domain; Region: Clp_N; pfam02861 575540002063 Clp amino terminal domain; Region: Clp_N; pfam02861 575540002064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002065 Walker A motif; other site 575540002066 ATP binding site [chemical binding]; other site 575540002067 Walker B motif; other site 575540002068 arginine finger; other site 575540002069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002070 Walker A motif; other site 575540002071 ATP binding site [chemical binding]; other site 575540002072 Walker B motif; other site 575540002073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 575540002074 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 575540002075 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 575540002076 nucleotide binding site [chemical binding]; other site 575540002077 NEF interaction site [polypeptide binding]; other site 575540002078 SBD interface [polypeptide binding]; other site 575540002079 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 575540002080 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540002081 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 575540002082 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540002083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 575540002084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 575540002085 Chorismate mutase type II; Region: CM_2; pfam01817 575540002086 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 575540002087 Prephenate dehydratase; Region: PDT; pfam00800 575540002088 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 575540002089 putative L-Phe binding site [chemical binding]; other site 575540002090 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540002091 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540002092 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540002093 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540002094 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540002095 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002096 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002097 active site 575540002098 ATP binding site [chemical binding]; other site 575540002099 substrate binding site [chemical binding]; other site 575540002100 activation loop (A-loop); other site 575540002101 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 575540002102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002103 TPR motif; other site 575540002104 TPR repeat; Region: TPR_11; pfam13414 575540002105 binding surface 575540002106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540002107 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 575540002108 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 575540002109 ligand binding site [chemical binding]; other site 575540002110 NAD binding site [chemical binding]; other site 575540002111 dimerization interface [polypeptide binding]; other site 575540002112 catalytic site [active] 575540002113 photolyase PhrII; Region: phr2; TIGR00591 575540002114 DNA photolyase; Region: DNA_photolyase; pfam00875 575540002115 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 575540002116 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002117 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002118 active site 575540002119 ATP binding site [chemical binding]; other site 575540002120 substrate binding site [chemical binding]; other site 575540002121 activation loop (A-loop); other site 575540002122 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 575540002123 GTP-binding protein LepA; Provisional; Region: PRK05433 575540002124 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 575540002125 G1 box; other site 575540002126 putative GEF interaction site [polypeptide binding]; other site 575540002127 GTP/Mg2+ binding site [chemical binding]; other site 575540002128 Switch I region; other site 575540002129 G2 box; other site 575540002130 G3 box; other site 575540002131 Switch II region; other site 575540002132 G4 box; other site 575540002133 G5 box; other site 575540002134 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 575540002135 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 575540002136 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 575540002137 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 575540002138 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540002139 Catalytic site [active] 575540002140 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540002141 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540002142 Catalytic site [active] 575540002143 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540002144 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 575540002145 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 575540002146 Walker A/P-loop; other site 575540002147 ATP binding site [chemical binding]; other site 575540002148 Q-loop/lid; other site 575540002149 ABC transporter signature motif; other site 575540002150 Walker B; other site 575540002151 D-loop; other site 575540002152 H-loop/switch region; other site 575540002153 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540002154 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540002155 HEAT repeats; Region: HEAT_2; pfam13646 575540002156 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 575540002157 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 575540002158 active site 575540002159 catalytic residues [active] 575540002160 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540002161 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 575540002162 endonuclease III; Region: ENDO3c; smart00478 575540002163 minor groove reading motif; other site 575540002164 helix-hairpin-helix signature motif; other site 575540002165 substrate binding pocket [chemical binding]; other site 575540002166 active site 575540002167 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 575540002168 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 575540002169 nucleotide binding site [chemical binding]; other site 575540002170 Oligomerisation domain; Region: Oligomerisation; pfam02410 575540002171 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 575540002172 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 575540002173 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 575540002174 active site 575540002175 HIGH motif; other site 575540002176 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 575540002177 KMSK motif region; other site 575540002178 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 575540002179 tRNA binding surface [nucleotide binding]; other site 575540002180 anticodon binding site; other site 575540002181 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 575540002182 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 575540002183 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 575540002184 Cytochrome c; Region: Cytochrom_C; pfam00034 575540002185 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540002186 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540002187 phosphopeptide binding site; other site 575540002188 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 575540002189 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 575540002190 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 575540002191 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 575540002192 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 575540002193 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 575540002194 active site 575540002195 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540002196 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540002197 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 575540002198 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 575540002199 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 575540002200 catalytic motif [active] 575540002201 Zn binding site [ion binding]; other site 575540002202 RibD C-terminal domain; Region: RibD_C; cl17279 575540002203 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540002204 HEAT repeats; Region: HEAT_2; pfam13646 575540002205 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 575540002206 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540002207 Cytochrome c; Region: Cytochrom_C; pfam00034 575540002208 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 575540002209 intersubunit interface [polypeptide binding]; other site 575540002210 active site 575540002211 catalytic residue [active] 575540002212 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540002213 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 575540002214 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540002215 Gas vesicle protein; Region: Gas_vesicle; pfam00741 575540002216 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 575540002217 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 575540002218 Zn binding sites [ion binding]; other site 575540002219 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 575540002220 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 575540002221 Zn binding sites [ion binding]; other site 575540002222 Gas vesicle protein K; Region: GvpK; pfam05121 575540002223 Gas vesicle protein; Region: Gas_vesicle; pfam00741 575540002224 Gas vesicle protein G; Region: GvpG; pfam05120 575540002225 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 575540002226 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 575540002227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002228 Walker A motif; other site 575540002229 ATP binding site [chemical binding]; other site 575540002230 Walker B motif; other site 575540002231 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 575540002232 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 575540002233 short chain dehydrogenase; Provisional; Region: PRK06197 575540002234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540002235 NAD(P) binding site [chemical binding]; other site 575540002236 active site 575540002237 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 575540002238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540002239 catalytic residue [active] 575540002240 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540002241 structural tetrad; other site 575540002242 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 575540002243 Phosphoesterase family; Region: Phosphoesterase; pfam04185 575540002244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 575540002245 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 575540002246 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 575540002247 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 575540002248 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 575540002249 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 575540002250 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 575540002251 molybdopterin cofactor binding site; other site 575540002252 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 575540002253 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 575540002254 4Fe-4S binding domain; Region: Fer4_2; pfam12797 575540002255 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 575540002256 heme-binding residues [chemical binding]; other site 575540002257 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540002258 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540002259 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540002260 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 575540002261 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 575540002262 active site 575540002263 HIGH motif; other site 575540002264 dimer interface [polypeptide binding]; other site 575540002265 KMSKS motif; other site 575540002266 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540002267 RNA binding surface [nucleotide binding]; other site 575540002268 CAAX protease self-immunity; Region: Abi; pfam02517 575540002269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002270 active site 575540002271 ATP binding site [chemical binding]; other site 575540002272 substrate binding site [chemical binding]; other site 575540002273 activation loop (A-loop); other site 575540002274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002275 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540002276 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 575540002277 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540002278 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540002279 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 575540002280 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540002281 G1 box; other site 575540002282 G1 box; other site 575540002283 GTP/Mg2+ binding site [chemical binding]; other site 575540002284 GTP/Mg2+ binding site [chemical binding]; other site 575540002285 G2 box; other site 575540002286 Switch I region; other site 575540002287 Switch I region; other site 575540002288 G2 box; other site 575540002289 G3 box; other site 575540002290 G3 box; other site 575540002291 Switch II region; other site 575540002292 Switch II region; other site 575540002293 G4 box; other site 575540002294 G5 box; other site 575540002295 TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666 575540002296 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 575540002297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002298 ATP binding site [chemical binding]; other site 575540002299 Mg2+ binding site [ion binding]; other site 575540002300 G-X-G motif; other site 575540002301 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 575540002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 575540002303 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 575540002304 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 575540002305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540002306 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 575540002307 Cysteine-rich domain; Region: CCG; pfam02754 575540002308 Cysteine-rich domain; Region: CCG; pfam02754 575540002309 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 575540002310 FAD binding domain; Region: FAD_binding_4; pfam01565 575540002311 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 575540002312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540002313 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540002314 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540002315 phosphopeptide binding site; other site 575540002316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 575540002317 GAF domain; Region: GAF_3; pfam13492 575540002318 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 575540002319 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 575540002320 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002321 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 575540002322 active site 2 [active] 575540002323 active site 1 [active] 575540002324 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 575540002325 tartrate dehydrogenase; Region: TTC; TIGR02089 575540002326 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 575540002327 nucleoside/Zn binding site; other site 575540002328 dimer interface [polypeptide binding]; other site 575540002329 catalytic motif [active] 575540002330 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 575540002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540002332 motif II; other site 575540002333 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 575540002334 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 575540002335 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 575540002336 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540002337 catalytic residue [active] 575540002338 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 575540002339 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 575540002340 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540002341 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540002342 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540002343 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540002344 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 575540002345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540002347 S-adenosylmethionine binding site [chemical binding]; other site 575540002348 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 575540002349 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 575540002350 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 575540002351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540002352 active site 575540002353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540002354 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540002355 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 575540002356 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 575540002357 dimer interface [polypeptide binding]; other site 575540002358 active site 575540002359 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 575540002360 Ion transport protein; Region: Ion_trans; pfam00520 575540002361 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 575540002362 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 575540002363 active site 575540002364 PHP-associated; Region: PHP_C; pfam13263 575540002365 Rhomboid family; Region: Rhomboid; cl11446 575540002366 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 575540002367 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 575540002368 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 575540002369 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 575540002370 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 575540002371 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 575540002372 ATP-sulfurylase; Region: ATPS; cd00517 575540002373 active site 575540002374 HXXH motif; other site 575540002375 flexible loop; other site 575540002376 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 575540002377 ligand-binding site [chemical binding]; other site 575540002378 Predicted transcriptional regulator [Transcription]; Region: COG1959 575540002379 Transcriptional regulator; Region: Rrf2; pfam02082 575540002380 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 575540002381 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 575540002382 Active Sites [active] 575540002383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540002384 dimer interface [polypeptide binding]; other site 575540002385 phosphorylation site [posttranslational modification] 575540002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002387 ATP binding site [chemical binding]; other site 575540002388 Mg2+ binding site [ion binding]; other site 575540002389 G-X-G motif; other site 575540002390 aconitate hydratase; Validated; Region: PRK09277 575540002391 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 575540002392 substrate binding site [chemical binding]; other site 575540002393 ligand binding site [chemical binding]; other site 575540002394 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 575540002395 substrate binding site [chemical binding]; other site 575540002396 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 575540002397 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 575540002398 tetramer interface [polypeptide binding]; other site 575540002399 TPP-binding site [chemical binding]; other site 575540002400 heterodimer interface [polypeptide binding]; other site 575540002401 phosphorylation loop region [posttranslational modification] 575540002402 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 575540002403 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 575540002404 alpha subunit interface [polypeptide binding]; other site 575540002405 TPP binding site [chemical binding]; other site 575540002406 heterodimer interface [polypeptide binding]; other site 575540002407 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 575540002408 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 575540002409 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 575540002410 E3 interaction surface; other site 575540002411 lipoyl attachment site [posttranslational modification]; other site 575540002412 e3 binding domain; Region: E3_binding; pfam02817 575540002413 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 575540002414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540002415 RNA binding surface [nucleotide binding]; other site 575540002416 Colicin V production protein; Region: Colicin_V; pfam02674 575540002417 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 575540002418 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 575540002419 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540002420 anti sigma factor interaction site; other site 575540002421 regulatory phosphorylation site [posttranslational modification]; other site 575540002422 Rhomboid family; Region: Rhomboid; pfam01694 575540002423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 575540002424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540002425 Coenzyme A binding pocket [chemical binding]; other site 575540002426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540002427 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 575540002428 active site 575540002429 metal binding site [ion binding]; metal-binding site 575540002430 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 575540002431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540002432 S-adenosylmethionine binding site [chemical binding]; other site 575540002433 Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999 575540002434 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540002435 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540002436 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540002437 structural tetrad; other site 575540002438 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 575540002439 Low-spin heme binding site [chemical binding]; other site 575540002440 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 575540002441 D-pathway; other site 575540002442 Putative water exit pathway; other site 575540002443 Binuclear center (active site) [active] 575540002444 K-pathway; other site 575540002445 Putative proton exit pathway; other site 575540002446 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 575540002447 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 575540002448 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 575540002449 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 575540002450 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 575540002451 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 575540002452 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 575540002453 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 575540002454 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 575540002455 UbiA prenyltransferase family; Region: UbiA; pfam01040 575540002456 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 575540002457 Subunit I/III interface [polypeptide binding]; other site 575540002458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 575540002459 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 575540002460 inhibitor-cofactor binding pocket; inhibition site 575540002461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540002462 catalytic residue [active] 575540002463 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 575540002464 AAA domain; Region: AAA_26; pfam13500 575540002465 TIGR03032 family protein; Region: TIGR03032 575540002466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002467 TPR motif; other site 575540002468 TPR repeat; Region: TPR_11; pfam13414 575540002469 binding surface 575540002470 TPR repeat; Region: TPR_11; pfam13414 575540002471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002472 binding surface 575540002473 TPR motif; other site 575540002474 TPR repeat; Region: TPR_11; pfam13414 575540002475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002476 binding surface 575540002477 TPR motif; other site 575540002478 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 575540002479 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 575540002480 ThiC family; Region: ThiC; pfam01964 575540002481 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 575540002482 putative efflux protein, MATE family; Region: matE; TIGR00797 575540002483 cation binding site [ion binding]; other site 575540002484 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 575540002485 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 575540002486 tetramerization interface [polypeptide binding]; other site 575540002487 active site 575540002488 Pantoate-beta-alanine ligase; Region: PanC; cd00560 575540002489 pantoate--beta-alanine ligase; Region: panC; TIGR00018 575540002490 active site 575540002491 ATP-binding site [chemical binding]; other site 575540002492 pantoate-binding site; other site 575540002493 HXXH motif; other site 575540002494 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 575540002495 dimer interface [polypeptide binding]; other site 575540002496 [2Fe-2S] cluster binding site [ion binding]; other site 575540002497 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 575540002498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 575540002499 MraW methylase family; Region: Methyltransf_5; cl17771 575540002500 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 575540002501 Trehalose utilisation; Region: ThuA; pfam06283 575540002502 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540002503 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540002504 Walker A/P-loop; other site 575540002505 ATP binding site [chemical binding]; other site 575540002506 Q-loop/lid; other site 575540002507 ABC transporter signature motif; other site 575540002508 Walker B; other site 575540002509 D-loop; other site 575540002510 H-loop/switch region; other site 575540002511 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 575540002512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 575540002513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 575540002514 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 575540002515 BON domain; Region: BON; pfam04972 575540002516 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540002517 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 575540002518 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002519 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002520 active site 575540002521 ATP binding site [chemical binding]; other site 575540002522 substrate binding site [chemical binding]; other site 575540002523 activation loop (A-loop); other site 575540002524 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 575540002525 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 575540002526 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 575540002527 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540002528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540002529 phosphopeptide binding site; other site 575540002530 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 575540002531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 575540002532 metal binding site [ion binding]; metal-binding site 575540002533 active site 575540002534 I-site; other site 575540002535 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540002536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540002537 dimerization interface [polypeptide binding]; other site 575540002538 putative DNA binding site [nucleotide binding]; other site 575540002539 putative Zn2+ binding site [ion binding]; other site 575540002540 Chlorite dismutase; Region: Chlor_dismutase; cl01280 575540002541 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 575540002542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 575540002543 E3 interaction surface; other site 575540002544 lipoyl attachment site [posttranslational modification]; other site 575540002545 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 575540002546 nudix motif; other site 575540002547 thymidylate kinase; Region: DTMP_kinase; TIGR00041 575540002548 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 575540002549 TMP-binding site; other site 575540002550 ATP-binding site [chemical binding]; other site 575540002551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002552 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 575540002553 Walker A motif; other site 575540002554 ATP binding site [chemical binding]; other site 575540002555 Walker B motif; other site 575540002556 arginine finger; other site 575540002557 Oxygen tolerance; Region: BatD; pfam13584 575540002558 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 575540002559 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 575540002560 Tetramer interface [polypeptide binding]; other site 575540002561 active site 575540002562 FMN-binding site [chemical binding]; other site 575540002563 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 575540002564 active site 575540002565 ATP binding site [chemical binding]; other site 575540002566 substrate binding site [chemical binding]; other site 575540002567 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 575540002568 GAF domain; Region: GAF_2; pfam13185 575540002569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540002570 dimer interface [polypeptide binding]; other site 575540002571 phosphorylation site [posttranslational modification] 575540002572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002573 ATP binding site [chemical binding]; other site 575540002574 Mg2+ binding site [ion binding]; other site 575540002575 G-X-G motif; other site 575540002576 Response regulator receiver domain; Region: Response_reg; pfam00072 575540002577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540002578 active site 575540002579 phosphorylation site [posttranslational modification] 575540002580 intermolecular recognition site; other site 575540002581 dimerization interface [polypeptide binding]; other site 575540002582 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 575540002583 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540002584 extended (e) SDRs; Region: SDR_e; cd08946 575540002585 NAD(P) binding site [chemical binding]; other site 575540002586 active site 575540002587 substrate binding site [chemical binding]; other site 575540002588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540002589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540002590 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 575540002591 NAD(P) binding site [chemical binding]; other site 575540002592 active site 575540002593 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 575540002594 putative glycosyl transferase; Provisional; Region: PRK10307 575540002595 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 575540002596 Cytochrome c; Region: Cytochrom_C; pfam00034 575540002597 PA14 domain; Region: PA14; cl08459 575540002598 Cytochrome c; Region: Cytochrom_C; pfam00034 575540002599 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540002600 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 575540002601 Bacterial sugar transferase; Region: Bac_transf; pfam02397 575540002602 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 575540002603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540002604 active site 575540002605 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 575540002606 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540002607 metal ion-dependent adhesion site (MIDAS); other site 575540002608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540002610 Walker A motif; other site 575540002611 ATP binding site [chemical binding]; other site 575540002612 Walker B motif; other site 575540002613 arginine finger; other site 575540002614 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 575540002615 HEAT repeats; Region: HEAT_2; pfam13646 575540002616 SWIM zinc finger; Region: SWIM; pfam04434 575540002617 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 575540002618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540002619 motif II; other site 575540002620 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540002621 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540002622 catalytic residue [active] 575540002623 acetolactate synthase; Region: PLN02470 575540002624 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 575540002625 PYR/PP interface [polypeptide binding]; other site 575540002626 dimer interface [polypeptide binding]; other site 575540002627 TPP binding site [chemical binding]; other site 575540002628 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 575540002629 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 575540002630 TPP-binding site [chemical binding]; other site 575540002631 dimer interface [polypeptide binding]; other site 575540002632 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540002633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540002634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540002635 DNA binding residues [nucleotide binding] 575540002636 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 575540002637 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 575540002638 trmE is a tRNA modification GTPase; Region: trmE; cd04164 575540002639 G1 box; other site 575540002640 GTP/Mg2+ binding site [chemical binding]; other site 575540002641 Switch I region; other site 575540002642 G2 box; other site 575540002643 Switch II region; other site 575540002644 G3 box; other site 575540002645 G4 box; other site 575540002646 G5 box; other site 575540002647 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 575540002648 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 575540002649 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 575540002650 putative active site [active] 575540002651 metal binding site [ion binding]; metal-binding site 575540002652 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540002653 Class I aldolases; Region: Aldolase_Class_I; cl17187 575540002654 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 575540002655 catalytic residue [active] 575540002656 PAS domain; Region: PAS; smart00091 575540002657 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 575540002658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540002659 putative active site [active] 575540002660 heme pocket [chemical binding]; other site 575540002661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540002662 dimer interface [polypeptide binding]; other site 575540002663 phosphorylation site [posttranslational modification] 575540002664 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 575540002665 Mg2+ binding site [ion binding]; other site 575540002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002667 ATP binding site [chemical binding]; other site 575540002668 G-X-G motif; other site 575540002669 Response regulator receiver domain; Region: Response_reg; pfam00072 575540002670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540002671 active site 575540002672 phosphorylation site [posttranslational modification] 575540002673 intermolecular recognition site; other site 575540002674 dimerization interface [polypeptide binding]; other site 575540002675 Family description; Region: VCBS; pfam13517 575540002676 Family description; Region: VCBS; pfam13517 575540002677 Family description; Region: VCBS; pfam13517 575540002678 Family description; Region: VCBS; pfam13517 575540002679 Family description; Region: VCBS; pfam13517 575540002680 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540002681 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540002682 dimer interface [polypeptide binding]; other site 575540002683 active site 575540002684 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 575540002685 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 575540002686 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 575540002687 Bacitracin resistance protein BacA; Region: BacA; pfam02673 575540002688 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 575540002689 Part of AAA domain; Region: AAA_19; pfam13245 575540002690 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 575540002691 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 575540002692 Family description; Region: UvrD_C_2; pfam13538 575540002693 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 575540002694 catalytic triad [active] 575540002695 putative active site [active] 575540002696 tartrate dehydrogenase; Region: TTC; TIGR02089 575540002697 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 575540002698 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540002699 Domain of unknown function (DUF362); Region: DUF362; pfam04015 575540002700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002701 TPR motif; other site 575540002702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540002703 binding surface 575540002704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002705 binding surface 575540002706 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540002707 TPR motif; other site 575540002708 PEP-CTERM motif; Region: VPEP; pfam07589 575540002709 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 575540002710 Clp amino terminal domain; Region: Clp_N; pfam02861 575540002711 Clp amino terminal domain; Region: Clp_N; pfam02861 575540002712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002713 Walker A motif; other site 575540002714 ATP binding site [chemical binding]; other site 575540002715 Walker B motif; other site 575540002716 arginine finger; other site 575540002717 UvrB/uvrC motif; Region: UVR; pfam02151 575540002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540002719 Walker A motif; other site 575540002720 ATP binding site [chemical binding]; other site 575540002721 Walker B motif; other site 575540002722 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 575540002723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002725 active site 575540002726 ATP binding site [chemical binding]; other site 575540002727 substrate binding site [chemical binding]; other site 575540002728 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002729 substrate binding site [chemical binding]; other site 575540002730 activation loop (A-loop); other site 575540002731 activation loop (A-loop); other site 575540002732 putative pectinesterase; Region: PLN02432; cl01911 575540002733 Right handed beta helix region; Region: Beta_helix; pfam13229 575540002734 Right handed beta helix region; Region: Beta_helix; pfam13229 575540002735 Right handed beta helix region; Region: Beta_helix; pfam13229 575540002736 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 575540002737 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 575540002738 NAD binding site [chemical binding]; other site 575540002739 substrate binding site [chemical binding]; other site 575540002740 active site 575540002741 potential frameshift: common BLAST hit: gi|32474083|ref|NP_867077.1| signal peptide 575540002742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 575540002743 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 575540002744 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 575540002745 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 575540002746 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 575540002747 catalytic residue [active] 575540002748 putative FPP diphosphate binding site; other site 575540002749 putative FPP binding hydrophobic cleft; other site 575540002750 dimer interface [polypeptide binding]; other site 575540002751 putative IPP diphosphate binding site; other site 575540002752 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 575540002753 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 575540002754 GDP-binding site [chemical binding]; other site 575540002755 ACT binding site; other site 575540002756 IMP binding site; other site 575540002757 PAS domain; Region: PAS; smart00091 575540002758 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540002759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540002760 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540002761 putative active site [active] 575540002762 heme pocket [chemical binding]; other site 575540002763 PAS domain; Region: PAS; smart00091 575540002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540002765 active site 575540002766 phosphorylation site [posttranslational modification] 575540002767 intermolecular recognition site; other site 575540002768 dimerization interface [polypeptide binding]; other site 575540002769 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 575540002770 Peptidase family M28; Region: Peptidase_M28; pfam04389 575540002771 metal binding site [ion binding]; metal-binding site 575540002772 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 575540002773 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 575540002774 metal binding site [ion binding]; metal-binding site 575540002775 dimer interface [polypeptide binding]; other site 575540002776 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 575540002777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540002778 NAD(P) binding site [chemical binding]; other site 575540002779 active site 575540002780 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 575540002781 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 575540002782 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 575540002783 putative active site [active] 575540002784 putative catalytic triad [active] 575540002785 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 575540002786 catalytic residues [active] 575540002787 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 575540002788 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 575540002789 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 575540002790 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 575540002791 putative active site [active] 575540002792 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 575540002793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540002794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540002795 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 575540002796 putative active site [active] 575540002797 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 575540002798 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540002799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540002800 S-adenosylmethionine binding site [chemical binding]; other site 575540002801 NAD binding site [chemical binding]; other site 575540002802 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 575540002803 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 575540002804 putative metal binding site; other site 575540002805 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 575540002806 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 575540002807 Probable Catalytic site; other site 575540002808 metal-binding site 575540002809 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 575540002810 phytoene desaturase; Region: crtI_fam; TIGR02734 575540002811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540002812 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 575540002813 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 575540002814 active site 575540002815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540002816 Putative Ig domain; Region: He_PIG; pfam05345 575540002817 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002819 active site 575540002820 ATP binding site [chemical binding]; other site 575540002821 substrate binding site [chemical binding]; other site 575540002822 activation loop (A-loop); other site 575540002823 TPR repeat; Region: TPR_11; pfam13414 575540002824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002825 TPR motif; other site 575540002826 binding surface 575540002827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002828 binding surface 575540002829 TPR motif; other site 575540002830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002831 binding surface 575540002832 TPR motif; other site 575540002833 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 575540002834 Domain of unknown function DUF11; Region: DUF11; cl17728 575540002835 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540002836 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540002837 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002838 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002839 active site 575540002840 ATP binding site [chemical binding]; other site 575540002841 substrate binding site [chemical binding]; other site 575540002842 activation loop (A-loop); other site 575540002843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002844 TPR motif; other site 575540002845 binding surface 575540002846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540002847 TPR motif; other site 575540002848 binding surface 575540002849 TPR repeat; Region: TPR_11; pfam13414 575540002850 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 575540002851 putative active site [active] 575540002852 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 575540002853 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 575540002854 putative acyl-acceptor binding pocket; other site 575540002855 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 575540002856 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 575540002857 active site 575540002858 dimer interface [polypeptide binding]; other site 575540002859 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 575540002860 Ligand Binding Site [chemical binding]; other site 575540002861 Molecular Tunnel; other site 575540002862 Protein of unknown function (DUF962); Region: DUF962; pfam06127 575540002863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540002864 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 575540002865 NAD(P) binding site [chemical binding]; other site 575540002866 active site 575540002867 MAPEG family; Region: MAPEG; pfam01124 575540002868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 575540002869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540002870 dimerization interface [polypeptide binding]; other site 575540002871 putative DNA binding site [nucleotide binding]; other site 575540002872 putative Zn2+ binding site [ion binding]; other site 575540002873 Protein of unknown function (DUF1464); Region: DUF1464; cl17839 575540002874 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540002875 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 575540002876 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 575540002877 NAD(P) binding pocket [chemical binding]; other site 575540002878 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 575540002879 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 575540002880 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 575540002881 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540002882 G1 box; other site 575540002883 GTP/Mg2+ binding site [chemical binding]; other site 575540002884 G2 box; other site 575540002885 Switch I region; other site 575540002886 G3 box; other site 575540002887 Switch II region; other site 575540002888 G4 box; other site 575540002889 G5 box; other site 575540002890 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 575540002891 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 575540002892 EamA-like transporter family; Region: EamA; pfam00892 575540002893 EamA-like transporter family; Region: EamA; pfam00892 575540002894 Permease; Region: Permease; pfam02405 575540002895 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 575540002896 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 575540002897 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 575540002898 active site 575540002899 GrpE; Region: GrpE; pfam01025 575540002900 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 575540002901 dimer interface [polypeptide binding]; other site 575540002902 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 575540002903 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 575540002904 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 575540002905 substrate binding site [chemical binding]; other site 575540002906 ATP binding site [chemical binding]; other site 575540002907 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 575540002908 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 575540002909 substrate binding site [chemical binding]; other site 575540002910 glutamase interaction surface [polypeptide binding]; other site 575540002911 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 575540002912 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 575540002913 Walker A motif; other site 575540002914 ATP binding site [chemical binding]; other site 575540002915 Walker B motif; other site 575540002916 Type II/IV secretion system protein; Region: T2SE; pfam00437 575540002917 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 575540002918 Walker A motif; other site 575540002919 ATP binding site [chemical binding]; other site 575540002920 Walker B motif; other site 575540002921 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 575540002922 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 575540002923 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 575540002924 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 575540002925 catalytic site [active] 575540002926 active site 575540002927 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 575540002928 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 575540002929 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 575540002930 active site 575540002931 catalytic site [active] 575540002932 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 575540002933 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 575540002934 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 575540002935 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 575540002936 active site 575540002937 catalytic site [active] 575540002938 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 575540002939 hypothetical protein; Reviewed; Region: PRK09588 575540002940 aspartate aminotransferase; Provisional; Region: PRK05764 575540002941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540002943 homodimer interface [polypeptide binding]; other site 575540002944 catalytic residue [active] 575540002945 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540002946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540002947 active site 575540002948 ATP binding site [chemical binding]; other site 575540002949 substrate binding site [chemical binding]; other site 575540002950 activation loop (A-loop); other site 575540002951 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540002952 cyclase homology domain; Region: CHD; cd07302 575540002953 dimer interface [polypeptide binding]; other site 575540002954 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 575540002955 nucleotidyl binding site; other site 575540002956 metal binding site [ion binding]; metal-binding site 575540002957 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 575540002958 Cell division protein FtsA; Region: FtsA; pfam14450 575540002959 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540002960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540002961 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540002962 putative active site [active] 575540002963 heme pocket [chemical binding]; other site 575540002964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540002965 putative active site [active] 575540002966 heme pocket [chemical binding]; other site 575540002967 GAF domain; Region: GAF_2; pfam13185 575540002968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540002969 dimer interface [polypeptide binding]; other site 575540002970 phosphorylation site [posttranslational modification] 575540002971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540002972 ATP binding site [chemical binding]; other site 575540002973 Mg2+ binding site [ion binding]; other site 575540002974 G-X-G motif; other site 575540002975 Response regulator receiver domain; Region: Response_reg; pfam00072 575540002976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540002977 active site 575540002978 phosphorylation site [posttranslational modification] 575540002979 intermolecular recognition site; other site 575540002980 dimerization interface [polypeptide binding]; other site 575540002981 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 575540002982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540002983 ABC transporter signature motif; other site 575540002984 Walker B; other site 575540002985 D-loop; other site 575540002986 H-loop/switch region; other site 575540002987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540002988 Walker A/P-loop; other site 575540002989 ATP binding site [chemical binding]; other site 575540002990 Q-loop/lid; other site 575540002991 ABC transporter signature motif; other site 575540002992 Walker B; other site 575540002993 D-loop; other site 575540002994 H-loop/switch region; other site 575540002995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 575540002996 putative acyl-acceptor binding pocket; other site 575540002997 CutC family; Region: CutC; cl01218 575540002998 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 575540002999 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 575540003000 nucleotide binding site [chemical binding]; other site 575540003001 putative NEF/HSP70 interaction site [polypeptide binding]; other site 575540003002 SBD interface [polypeptide binding]; other site 575540003003 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540003004 metal ion-dependent adhesion site (MIDAS); other site 575540003005 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 575540003006 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 575540003007 active site 575540003008 catalytic motif [active] 575540003009 Zn binding site [ion binding]; other site 575540003010 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 575540003011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 575540003012 acyl-activating enzyme (AAE) consensus motif; other site 575540003013 AMP binding site [chemical binding]; other site 575540003014 active site 575540003015 CoA binding site [chemical binding]; other site 575540003016 Cupin domain; Region: Cupin_2; pfam07883 575540003017 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540003018 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 575540003019 rRNA binding site [nucleotide binding]; other site 575540003020 predicted 30S ribosome binding site; other site 575540003021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540003022 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 575540003023 NAD(P) binding site [chemical binding]; other site 575540003024 active site 575540003025 peptide synthase; Provisional; Region: PRK09274 575540003026 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 575540003027 acyl-activating enzyme (AAE) consensus motif; other site 575540003028 putative AMP binding site [chemical binding]; other site 575540003029 putative active site [active] 575540003030 putative CoA binding site [chemical binding]; other site 575540003031 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 575540003032 Beta-lactamase; Region: Beta-lactamase; pfam00144 575540003033 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 575540003034 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 575540003035 Walker A/P-loop; other site 575540003036 ATP binding site [chemical binding]; other site 575540003037 Q-loop/lid; other site 575540003038 ABC transporter signature motif; other site 575540003039 Walker B; other site 575540003040 D-loop; other site 575540003041 H-loop/switch region; other site 575540003042 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 575540003043 ABC-2 type transporter; Region: ABC2_membrane; cl17235 575540003044 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 575540003045 Maf-like protein; Region: Maf; pfam02545 575540003046 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 575540003047 active site 575540003048 dimer interface [polypeptide binding]; other site 575540003049 sulfite reductase subunit beta; Provisional; Region: PRK13504 575540003050 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 575540003051 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 575540003052 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 575540003053 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 575540003054 Potassium binding sites [ion binding]; other site 575540003055 Cesium cation binding sites [ion binding]; other site 575540003056 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540003057 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 575540003058 G1 box; other site 575540003059 GTP/Mg2+ binding site [chemical binding]; other site 575540003060 G2 box; other site 575540003061 Switch I region; other site 575540003062 G3 box; other site 575540003063 Switch II region; other site 575540003064 G4 box; other site 575540003065 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 575540003066 G1 box; other site 575540003067 GTP/Mg2+ binding site [chemical binding]; other site 575540003068 G2 box; other site 575540003069 Switch I region; other site 575540003070 G3 box; other site 575540003071 Switch II region; other site 575540003072 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 575540003073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 575540003074 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 575540003075 ABC-ATPase subunit interface; other site 575540003076 dimer interface [polypeptide binding]; other site 575540003077 putative PBP binding regions; other site 575540003078 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 575540003079 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 575540003080 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 575540003081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 575540003082 ABC-ATPase subunit interface; other site 575540003083 dimer interface [polypeptide binding]; other site 575540003084 putative PBP binding regions; other site 575540003085 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 575540003086 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 575540003087 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 575540003088 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 575540003089 intersubunit interface [polypeptide binding]; other site 575540003090 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 575540003091 active site 575540003092 NAD binding site [chemical binding]; other site 575540003093 metal binding site [ion binding]; metal-binding site 575540003094 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 575540003095 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 575540003096 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 575540003097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540003098 ATP binding site [chemical binding]; other site 575540003099 putative Mg++ binding site [ion binding]; other site 575540003100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540003101 nucleotide binding region [chemical binding]; other site 575540003102 ATP-binding site [chemical binding]; other site 575540003103 TRCF domain; Region: TRCF; pfam03461 575540003104 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 575540003105 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 575540003106 active site 575540003107 Riboflavin kinase; Region: Flavokinase; pfam01687 575540003108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540003109 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 575540003110 VanZ like family; Region: VanZ; pfam04892 575540003111 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 575540003112 active site 575540003113 catalytic residues [active] 575540003114 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540003115 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540003116 Bacterial Ig-like domain; Region: Big_5; pfam13205 575540003117 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 575540003118 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540003119 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540003120 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 575540003121 ParB-like nuclease domain; Region: ParBc; pfam02195 575540003122 Helix-turn-helix; Region: HTH_3; pfam01381 575540003123 non-specific DNA binding site [nucleotide binding]; other site 575540003124 salt bridge; other site 575540003125 sequence-specific DNA binding site [nucleotide binding]; other site 575540003126 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 575540003127 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 575540003128 active site 575540003129 ADP/pyrophosphate binding site [chemical binding]; other site 575540003130 dimerization interface [polypeptide binding]; other site 575540003131 allosteric effector site; other site 575540003132 fructose-1,6-bisphosphate binding site; other site 575540003133 TPR repeat; Region: TPR_11; pfam13414 575540003134 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 575540003135 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 575540003136 protein binding site [polypeptide binding]; other site 575540003137 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 575540003138 Catalytic dyad [active] 575540003139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540003140 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540003141 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 575540003142 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 575540003143 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 575540003144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540003145 NAD(P) binding site [chemical binding]; other site 575540003146 active site 575540003147 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 575540003148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540003149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540003150 homodimer interface [polypeptide binding]; other site 575540003151 catalytic residue [active] 575540003152 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 575540003153 competence damage-inducible protein A; Provisional; Region: PRK00549 575540003154 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 575540003155 putative MPT binding site; other site 575540003156 Competence-damaged protein; Region: CinA; pfam02464 575540003157 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 575540003158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 575540003159 active site 575540003160 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540003161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540003162 NAD(P) binding site [chemical binding]; other site 575540003163 active site 575540003164 DNA topoisomerase I; Validated; Region: PRK06599 575540003165 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 575540003166 active site 575540003167 interdomain interaction site; other site 575540003168 putative metal-binding site [ion binding]; other site 575540003169 nucleotide binding site [chemical binding]; other site 575540003170 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 575540003171 domain I; other site 575540003172 DNA binding groove [nucleotide binding] 575540003173 phosphate binding site [ion binding]; other site 575540003174 domain II; other site 575540003175 domain III; other site 575540003176 nucleotide binding site [chemical binding]; other site 575540003177 catalytic site [active] 575540003178 domain IV; other site 575540003179 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 575540003180 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 575540003181 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 575540003182 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 575540003183 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 575540003184 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 575540003185 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 575540003186 Fasciclin domain; Region: Fasciclin; pfam02469 575540003187 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 575540003188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540003189 NAD(P) binding site [chemical binding]; other site 575540003190 active site 575540003191 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 575540003192 deoxyhypusine synthase; Region: dhys; TIGR00321 575540003193 CAAX protease self-immunity; Region: Abi; cl00558 575540003194 Uncharacterized conserved protein [Function unknown]; Region: COG3391 575540003195 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 575540003196 Phosphoesterase family; Region: Phosphoesterase; pfam04185 575540003197 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 575540003198 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540003199 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540003200 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540003201 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 575540003202 nuclear egress membrane protein UL34; Provisional; Region: PHA03324 575540003203 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 575540003204 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 575540003205 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 575540003206 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 575540003207 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 575540003208 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 575540003209 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 575540003210 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 575540003211 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 575540003212 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 575540003213 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 575540003214 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 575540003215 dimerization domain swap beta strand [polypeptide binding]; other site 575540003216 regulatory protein interface [polypeptide binding]; other site 575540003217 active site 575540003218 regulatory phosphorylation site [posttranslational modification]; other site 575540003219 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 575540003220 active site 575540003221 phosphorylation site [posttranslational modification] 575540003222 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 575540003223 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 575540003224 chorismate binding enzyme; Region: Chorismate_bind; cl10555 575540003225 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 575540003226 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 575540003227 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540003228 Sulfatase; Region: Sulfatase; cl17466 575540003229 Sulfatase; Region: Sulfatase; cl17466 575540003230 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540003231 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 575540003232 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 575540003233 AMP binding site [chemical binding]; other site 575540003234 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 575540003235 metal binding site [ion binding]; metal-binding site 575540003236 active site 575540003237 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 575540003238 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 575540003239 ligand binding site [chemical binding]; other site 575540003240 homodimer interface [polypeptide binding]; other site 575540003241 NAD(P) binding site [chemical binding]; other site 575540003242 trimer interface B [polypeptide binding]; other site 575540003243 trimer interface A [polypeptide binding]; other site 575540003244 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 575540003245 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 575540003246 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 575540003247 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 575540003248 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 575540003249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540003250 catalytic residue [active] 575540003251 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 575540003252 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 575540003253 active site 575540003254 biotin synthase; Region: bioB; TIGR00433 575540003255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540003256 FeS/SAM binding site; other site 575540003257 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 575540003258 Flagellin N-methylase; Region: FliB; pfam03692 575540003259 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 575540003260 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 575540003261 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 575540003262 Peptidase family M50; Region: Peptidase_M50; pfam02163 575540003263 active site 575540003264 putative substrate binding region [chemical binding]; other site 575540003265 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 575540003266 aromatic arch; other site 575540003267 DCoH dimer interaction site [polypeptide binding]; other site 575540003268 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 575540003269 DCoH tetramer interaction site [polypeptide binding]; other site 575540003270 substrate binding site [chemical binding]; other site 575540003271 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 575540003272 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 575540003273 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 575540003274 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 575540003275 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 575540003276 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 575540003277 NAD-dependent deacetylase; Provisional; Region: PRK00481 575540003278 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 575540003279 NAD+ binding site [chemical binding]; other site 575540003280 substrate binding site [chemical binding]; other site 575540003281 Zn binding site [ion binding]; other site 575540003282 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 575540003283 argininosuccinate lyase; Provisional; Region: PRK00855 575540003284 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 575540003285 active sites [active] 575540003286 tetramer interface [polypeptide binding]; other site 575540003287 diaminopimelate decarboxylase; Region: lysA; TIGR01048 575540003288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 575540003289 active site 575540003290 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 575540003291 substrate binding site [chemical binding]; other site 575540003292 catalytic residues [active] 575540003293 dimer interface [polypeptide binding]; other site 575540003294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540003295 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540003296 Walker A motif; other site 575540003297 ATP binding site [chemical binding]; other site 575540003298 Walker B motif; other site 575540003299 arginine finger; other site 575540003300 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 575540003301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540003302 putative substrate translocation pore; other site 575540003303 POT family; Region: PTR2; cl17359 575540003304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 575540003305 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 575540003306 Ligand binding site; other site 575540003307 Putative Catalytic site; other site 575540003308 DXD motif; other site 575540003309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 575540003310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 575540003311 non-specific DNA binding site [nucleotide binding]; other site 575540003312 salt bridge; other site 575540003313 sequence-specific DNA binding site [nucleotide binding]; other site 575540003314 Cupin domain; Region: Cupin_2; pfam07883 575540003315 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 575540003316 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 575540003317 NAD(P) binding site [chemical binding]; other site 575540003318 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 575540003319 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 575540003320 substrate-cofactor binding pocket; other site 575540003321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540003322 catalytic residue [active] 575540003323 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540003325 active site 575540003326 phosphorylation site [posttranslational modification] 575540003327 intermolecular recognition site; other site 575540003328 dimerization interface [polypeptide binding]; other site 575540003329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540003330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540003331 dimer interface [polypeptide binding]; other site 575540003332 phosphorylation site [posttranslational modification] 575540003333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540003334 ATP binding site [chemical binding]; other site 575540003335 Mg2+ binding site [ion binding]; other site 575540003336 G-X-G motif; other site 575540003337 PAS fold; Region: PAS_2; pfam08446 575540003338 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 575540003339 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 575540003340 Phytochrome region; Region: PHY; pfam00360 575540003341 PAS fold; Region: PAS; pfam00989 575540003342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540003343 putative active site [active] 575540003344 heme pocket [chemical binding]; other site 575540003345 PAS fold; Region: PAS_3; pfam08447 575540003346 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540003347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 575540003348 Histidine kinase; Region: HisKA_2; pfam07568 575540003349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540003350 ATP binding site [chemical binding]; other site 575540003351 Mg2+ binding site [ion binding]; other site 575540003352 G-X-G motif; other site 575540003353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540003354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540003355 Walker A/P-loop; other site 575540003356 ATP binding site [chemical binding]; other site 575540003357 Q-loop/lid; other site 575540003358 ABC transporter signature motif; other site 575540003359 Walker B; other site 575540003360 D-loop; other site 575540003361 H-loop/switch region; other site 575540003362 inner membrane transport permease; Provisional; Region: PRK15066 575540003363 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 575540003364 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540003365 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540003366 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540003367 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540003368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540003370 S-adenosylmethionine binding site [chemical binding]; other site 575540003371 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540003372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003373 binding surface 575540003374 TPR motif; other site 575540003375 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540003376 TPR repeat; Region: TPR_11; pfam13414 575540003377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003378 binding surface 575540003379 TPR motif; other site 575540003380 TPR repeat; Region: TPR_11; pfam13414 575540003381 TPR repeat; Region: TPR_11; pfam13414 575540003382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003383 binding surface 575540003384 TPR motif; other site 575540003385 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540003386 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 575540003387 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 575540003388 nucleotide binding pocket [chemical binding]; other site 575540003389 K-X-D-G motif; other site 575540003390 catalytic site [active] 575540003391 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 575540003392 Helix-hairpin-helix motif; Region: HHH; pfam00633 575540003393 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 575540003394 putative ADP-binding pocket [chemical binding]; other site 575540003395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540003396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540003397 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 575540003398 putative ADP-binding pocket [chemical binding]; other site 575540003399 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 575540003400 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 575540003401 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 575540003402 active site 575540003403 homodimer interface [polypeptide binding]; other site 575540003404 catalytic site [active] 575540003405 acceptor binding site [chemical binding]; other site 575540003406 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 575540003407 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 575540003408 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 575540003409 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 575540003410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 575540003411 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 575540003412 substrate binding site [chemical binding]; other site 575540003413 oxyanion hole (OAH) forming residues; other site 575540003414 trimer interface [polypeptide binding]; other site 575540003415 DsrE/DsrF-like family; Region: DrsE; pfam02635 575540003416 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 575540003417 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 575540003418 TPP-binding site [chemical binding]; other site 575540003419 dimer interface [polypeptide binding]; other site 575540003420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 575540003421 PYR/PP interface [polypeptide binding]; other site 575540003422 dimer interface [polypeptide binding]; other site 575540003423 TPP binding site [chemical binding]; other site 575540003424 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 575540003425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003426 active site 575540003427 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 575540003428 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 575540003429 Beta-lactamase; Region: Beta-lactamase; pfam00144 575540003430 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 575540003431 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 575540003432 homodimer interface [polypeptide binding]; other site 575540003433 substrate-cofactor binding pocket; other site 575540003434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540003435 catalytic residue [active] 575540003436 Outer membrane efflux protein; Region: OEP; pfam02321 575540003437 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 575540003438 Domain of unknown function DUF21; Region: DUF21; pfam01595 575540003439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 575540003440 Transporter associated domain; Region: CorC_HlyC; smart01091 575540003441 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540003442 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540003443 phosphopeptide binding site; other site 575540003444 ribosomal protein S1; Region: rpsA; TIGR00717 575540003445 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 575540003446 RNA binding site [nucleotide binding]; other site 575540003447 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 575540003448 RNA binding site [nucleotide binding]; other site 575540003449 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 575540003450 RNA binding site [nucleotide binding]; other site 575540003451 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 575540003452 RNA binding site [nucleotide binding]; other site 575540003453 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 575540003454 RNA binding site [nucleotide binding]; other site 575540003455 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 575540003456 RNA binding site [nucleotide binding]; other site 575540003457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540003458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540003459 S-adenosylmethionine binding site [chemical binding]; other site 575540003460 30S ribosomal protein S7; Validated; Region: PRK05302 575540003461 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 575540003462 S17 interaction site [polypeptide binding]; other site 575540003463 S8 interaction site; other site 575540003464 16S rRNA interaction site [nucleotide binding]; other site 575540003465 streptomycin interaction site [chemical binding]; other site 575540003466 23S rRNA interaction site [nucleotide binding]; other site 575540003467 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 575540003468 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 575540003469 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 575540003470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540003471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540003472 active site 575540003473 ATP binding site [chemical binding]; other site 575540003474 substrate binding site [chemical binding]; other site 575540003475 activation loop (A-loop); other site 575540003476 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 575540003477 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 575540003478 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 575540003479 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 575540003480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003481 binding surface 575540003482 TPR motif; other site 575540003483 Family description; Region: VCBS; pfam13517 575540003484 Family description; Region: VCBS; pfam13517 575540003485 Family description; Region: VCBS; pfam13517 575540003486 Family description; Region: VCBS; pfam13517 575540003487 Family description; Region: VCBS; pfam13517 575540003488 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 575540003489 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540003491 active site 575540003492 phosphorylation site [posttranslational modification] 575540003493 intermolecular recognition site; other site 575540003494 dimerization interface [polypeptide binding]; other site 575540003495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540003496 Walker A motif; other site 575540003497 ATP binding site [chemical binding]; other site 575540003498 Walker B motif; other site 575540003499 arginine finger; other site 575540003500 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540003501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 575540003502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540003503 phosphorylation site [posttranslational modification] 575540003504 dimer interface [polypeptide binding]; other site 575540003505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540003506 ATP binding site [chemical binding]; other site 575540003507 Mg2+ binding site [ion binding]; other site 575540003508 G-X-G motif; other site 575540003509 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 575540003510 homodimer interface [polypeptide binding]; other site 575540003511 chemical substrate binding site [chemical binding]; other site 575540003512 oligomer interface [polypeptide binding]; other site 575540003513 metal binding site [ion binding]; metal-binding site 575540003514 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 575540003515 Paraquat-inducible protein A; Region: PqiA; pfam04403 575540003516 mce related protein; Region: MCE; pfam02470 575540003517 mce related protein; Region: MCE; pfam02470 575540003518 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 575540003519 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 575540003520 ligand binding site; other site 575540003521 oligomer interface; other site 575540003522 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 575540003523 dimer interface [polypeptide binding]; other site 575540003524 N-terminal domain interface [polypeptide binding]; other site 575540003525 sulfate 1 binding site; other site 575540003526 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003527 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 575540003528 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 575540003529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540003530 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003531 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 575540003532 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003533 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003534 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003535 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 575540003536 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 575540003537 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 575540003538 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 575540003539 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 575540003540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540003541 active site 575540003542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 575540003543 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540003544 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540003545 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540003546 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540003547 Sulfatase; Region: Sulfatase; cl17466 575540003548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540003549 active site 575540003550 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540003551 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540003552 ferrochelatase; Reviewed; Region: hemH; PRK00035 575540003553 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 575540003554 C-terminal domain interface [polypeptide binding]; other site 575540003555 active site 575540003556 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 575540003557 active site 575540003558 N-terminal domain interface [polypeptide binding]; other site 575540003559 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 575540003560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540003561 active site 575540003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540003563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 575540003564 putative substrate translocation pore; other site 575540003565 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 575540003566 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 575540003567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540003568 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 575540003569 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 575540003570 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540003571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540003572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540003573 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 575540003574 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540003575 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540003576 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 575540003577 dihydrodipicolinate synthase; Region: dapA; TIGR00674 575540003578 dimer interface [polypeptide binding]; other site 575540003579 active site 575540003580 catalytic residue [active] 575540003581 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 575540003582 Na binding site [ion binding]; other site 575540003583 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 575540003584 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540003585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540003586 dimer interface [polypeptide binding]; other site 575540003587 active site 575540003588 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 575540003589 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 575540003590 dimer interface [polypeptide binding]; other site 575540003591 active site 575540003592 acyl carrier protein; Provisional; Region: acpP; PRK00982 575540003593 selenocysteine synthase; Provisional; Region: PRK04311 575540003594 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540003595 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540003596 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540003597 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540003598 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 575540003599 DNA interaction; other site 575540003600 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 575540003601 DNA gyrase subunit A; Validated; Region: PRK05560 575540003602 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 575540003603 CAP-like domain; other site 575540003604 active site 575540003605 primary dimer interface [polypeptide binding]; other site 575540003606 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003608 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003609 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003610 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003611 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540003612 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 575540003613 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540003614 Sulfatase; Region: Sulfatase; cl17466 575540003615 Amino acid permease; Region: AA_permease_2; pfam13520 575540003616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 575540003617 Ligand Binding Site [chemical binding]; other site 575540003618 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540003619 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540003620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540003621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540003622 binding surface 575540003623 TPR motif; other site 575540003624 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003626 Tetratricopeptide repeat; Region: TPR_15; pfam13429 575540003627 binding surface 575540003628 TPR motif; other site 575540003629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540003630 binding surface 575540003631 TPR motif; other site 575540003632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540003633 active site 575540003634 ATP binding site [chemical binding]; other site 575540003635 substrate binding site [chemical binding]; other site 575540003636 activation loop (A-loop); other site 575540003637 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 575540003638 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 575540003639 dimer interface [polypeptide binding]; other site 575540003640 putative functional site; other site 575540003641 putative MPT binding site; other site 575540003642 PBP superfamily domain; Region: PBP_like; pfam12727 575540003643 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003645 active site 575540003646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003647 active site 575540003648 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 575540003649 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003650 active site 575540003651 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 575540003652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003653 active site 575540003654 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003655 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003656 active site 575540003657 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 575540003658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003659 active site 575540003660 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 575540003661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003662 active site 575540003663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003665 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540003666 active site 575540003667 Methane oxygenase PmoA; Region: PmoA; pfam14100 575540003668 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 575540003669 DNA polymerase III, delta subunit; Region: holA; TIGR01128 575540003670 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 575540003671 cyclase homology domain; Region: CHD; cd07302 575540003672 nucleotidyl binding site; other site 575540003673 metal binding site [ion binding]; metal-binding site 575540003674 dimer interface [polypeptide binding]; other site 575540003675 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540003676 HEAT repeats; Region: HEAT_2; pfam13646 575540003677 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540003678 Cytochrome c; Region: Cytochrom_C; pfam00034 575540003679 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 575540003680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540003681 S-adenosylmethionine binding site [chemical binding]; other site 575540003682 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 575540003683 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 575540003684 active site 575540003685 NTP binding site [chemical binding]; other site 575540003686 metal binding triad [ion binding]; metal-binding site 575540003687 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 575540003688 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 575540003689 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 575540003690 Fe-S cluster binding site [ion binding]; other site 575540003691 active site 575540003692 TPR repeat; Region: TPR_11; pfam13414 575540003693 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 575540003694 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540003695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540003696 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540003697 Sulfatase; Region: Sulfatase; pfam00884 575540003698 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 575540003699 isocitrate dehydrogenase; Validated; Region: PRK06451 575540003700 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 575540003701 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 575540003702 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 575540003703 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 575540003704 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 575540003705 putative active site [active] 575540003706 glutamate dehydrogenase; Region: PLN02477 575540003707 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 575540003708 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 575540003709 NAD(P) binding site [chemical binding]; other site 575540003710 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 575540003711 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 575540003712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540003713 Zn2+ binding site [ion binding]; other site 575540003714 Mg2+ binding site [ion binding]; other site 575540003715 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 575540003716 PhoH-like protein; Region: PhoH; pfam02562 575540003717 Response regulator receiver domain; Region: Response_reg; pfam00072 575540003718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540003719 active site 575540003720 phosphorylation site [posttranslational modification] 575540003721 intermolecular recognition site; other site 575540003722 dimerization interface [polypeptide binding]; other site 575540003723 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 575540003724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 575540003725 NAD(P) binding site [chemical binding]; other site 575540003726 catalytic residues [active] 575540003727 Penicillinase repressor; Region: Pencillinase_R; cl17580 575540003728 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 575540003729 active site 575540003730 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 575540003731 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 575540003732 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 575540003733 active site 575540003734 octamer interface [polypeptide binding]; other site 575540003735 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540003736 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540003737 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540003738 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 575540003739 Helix-turn-helix domain; Region: HTH_17; pfam12728 575540003740 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 575540003741 Ferritin-like domain; Region: Ferritin; pfam00210 575540003742 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 575540003743 dinuclear metal binding motif [ion binding]; other site 575540003744 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 575540003745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 575540003746 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003747 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 575540003748 Y-family of DNA polymerases; Region: PolY; cl12025 575540003749 active site 575540003750 DNA binding site [nucleotide binding] 575540003751 impB/mucB/samB family C-terminal; Region: IMS_C; pfam11799 575540003752 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 575540003753 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 575540003754 Rhomboid family; Region: Rhomboid; pfam01694 575540003755 RF-1 domain; Region: RF-1; pfam00472 575540003756 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 575540003757 Right handed beta helix region; Region: Beta_helix; pfam13229 575540003758 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 575540003759 Right handed beta helix region; Region: Beta_helix; pfam13229 575540003760 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 575540003761 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 575540003762 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 575540003763 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 575540003764 Right handed beta helix region; Region: Beta_helix; pfam13229 575540003765 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 575540003766 Calx-beta domain; Region: Calx-beta; cl02522 575540003767 Calx-beta domain; Region: Calx-beta; cl02522 575540003768 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 575540003769 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 575540003770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 575540003771 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 575540003772 Methyltransferase domain; Region: Methyltransf_26; pfam13659 575540003773 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 575540003774 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 575540003775 active site 575540003776 PHP Thumb interface [polypeptide binding]; other site 575540003777 metal binding site [ion binding]; metal-binding site 575540003778 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 575540003779 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 575540003780 generic binding surface II; other site 575540003781 generic binding surface I; other site 575540003782 AAA ATPase domain; Region: AAA_16; pfam13191 575540003783 AAA domain; Region: AAA_22; pfam13401 575540003784 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 575540003785 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 575540003786 trimer interface [polypeptide binding]; other site 575540003787 active site 575540003788 substrate binding site [chemical binding]; other site 575540003789 CoA binding site [chemical binding]; other site 575540003790 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540003791 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 575540003792 Metal-binding active site; metal-binding site 575540003793 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 575540003794 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 575540003795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540003796 catalytic core [active] 575540003797 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 575540003798 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 575540003799 putative acyl-acceptor binding pocket; other site 575540003800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540003801 S-adenosylmethionine binding site [chemical binding]; other site 575540003802 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 575540003803 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 575540003804 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 575540003805 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 575540003806 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 575540003807 E3 interaction residues; other site 575540003808 Ub thioester intermediate interaction residues; other site 575540003809 active site cysteine 575540003810 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 575540003811 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 575540003812 ATP binding site [chemical binding]; other site 575540003813 substrate interface [chemical binding]; other site 575540003814 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 575540003815 MMPL family; Region: MMPL; pfam03176 575540003816 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 575540003817 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 575540003818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540003819 Walker A/P-loop; other site 575540003820 ATP binding site [chemical binding]; other site 575540003821 Q-loop/lid; other site 575540003822 ABC transporter signature motif; other site 575540003823 Walker B; other site 575540003824 D-loop; other site 575540003825 H-loop/switch region; other site 575540003826 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 575540003827 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540003828 HEAT repeats; Region: HEAT_2; pfam13646 575540003829 HEAT repeats; Region: HEAT_2; pfam13646 575540003830 HEAT repeats; Region: HEAT_2; pfam13646 575540003831 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 575540003832 protein binding surface [polypeptide binding]; other site 575540003833 HEAT repeats; Region: HEAT_2; pfam13646 575540003834 Cytochrome c; Region: Cytochrom_C; cl11414 575540003835 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540003836 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 575540003837 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 575540003838 tetramer interface [polypeptide binding]; other site 575540003839 active site 575540003840 Mg2+/Mn2+ binding site [ion binding]; other site 575540003841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 575540003842 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 575540003843 substrate binding site [chemical binding]; other site 575540003844 ATP binding site [chemical binding]; other site 575540003845 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 575540003846 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 575540003847 DNA binding site [nucleotide binding] 575540003848 catalytic residue [active] 575540003849 H2TH interface [polypeptide binding]; other site 575540003850 putative catalytic residues [active] 575540003851 turnover-facilitating residue; other site 575540003852 intercalation triad [nucleotide binding]; other site 575540003853 8OG recognition residue [nucleotide binding]; other site 575540003854 putative reading head residues; other site 575540003855 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 575540003856 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 575540003857 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003858 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 575540003859 lipoyl synthase; Provisional; Region: PRK05481 575540003860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540003861 FeS/SAM binding site; other site 575540003862 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 575540003863 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 575540003864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540003865 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 575540003866 Walker A/P-loop; other site 575540003867 ATP binding site [chemical binding]; other site 575540003868 Q-loop/lid; other site 575540003869 ABC transporter signature motif; other site 575540003870 Walker B; other site 575540003871 D-loop; other site 575540003872 H-loop/switch region; other site 575540003873 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 575540003874 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540003875 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540003876 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 575540003877 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 575540003878 active site 575540003879 catalytic triad [active] 575540003880 dimer interface [polypeptide binding]; other site 575540003881 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540003882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 575540003883 Walker A motif; other site 575540003884 ATP binding site [chemical binding]; other site 575540003885 AAA domain; Region: AAA_12; pfam13087 575540003886 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 575540003887 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 575540003888 Na binding site [ion binding]; other site 575540003889 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540003890 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 575540003891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540003892 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 575540003893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540003894 DNA binding residues [nucleotide binding] 575540003895 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 575540003896 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 575540003897 FHIPEP family; Region: FHIPEP; pfam00771 575540003898 FHIPEP family; Region: FHIPEP; pfam00771 575540003899 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 575540003900 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 575540003901 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 575540003902 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 575540003903 FeoA domain; Region: FeoA; pfam04023 575540003904 Domain of unknown function (DUF427); Region: DUF427; pfam04248 575540003905 Peptidase S46; Region: Peptidase_S46; pfam10459 575540003906 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540003907 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540003908 EamA-like transporter family; Region: EamA; pfam00892 575540003909 EamA-like transporter family; Region: EamA; cl17759 575540003910 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 575540003911 threonine synthase; Validated; Region: PRK07591 575540003912 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 575540003913 homodimer interface [polypeptide binding]; other site 575540003914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540003915 catalytic residue [active] 575540003916 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 575540003917 MoaE interaction surface [polypeptide binding]; other site 575540003918 MoeB interaction surface [polypeptide binding]; other site 575540003919 thiocarboxylated glycine; other site 575540003920 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 575540003921 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 575540003922 ATP binding site [chemical binding]; other site 575540003923 substrate interface [chemical binding]; other site 575540003924 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 575540003925 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 575540003926 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540003927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540003928 catalytic residue [active] 575540003929 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 575540003930 Peptidase family M1; Region: Peptidase_M1; pfam01433 575540003931 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 575540003932 Zn binding site [ion binding]; other site 575540003933 Zn binding site [ion binding]; other site 575540003934 HEAT repeats; Region: HEAT_2; pfam13646 575540003935 HEAT repeats; Region: HEAT_2; pfam13646 575540003936 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540003937 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 575540003938 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 575540003939 NAD(P) binding site [chemical binding]; other site 575540003940 Clp protease; Region: CLP_protease; pfam00574 575540003941 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 575540003942 oligomer interface [polypeptide binding]; other site 575540003943 active site residues [active] 575540003944 Clp protease; Region: CLP_protease; pfam00574 575540003945 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 575540003946 oligomer interface [polypeptide binding]; other site 575540003947 active site residues [active] 575540003948 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 575540003949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540003950 FeS/SAM binding site; other site 575540003951 nitrilase; Region: PLN02798 575540003952 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 575540003953 putative active site [active] 575540003954 catalytic triad [active] 575540003955 dimer interface [polypeptide binding]; other site 575540003956 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 575540003957 Pyruvate formate lyase 1; Region: PFL1; cd01678 575540003958 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 575540003959 coenzyme A binding site [chemical binding]; other site 575540003960 active site 575540003961 catalytic residues [active] 575540003962 glycine loop; other site 575540003963 Putative zinc-finger; Region: zf-HC2; pfam13490 575540003964 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 575540003965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540003966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540003967 DNA binding residues [nucleotide binding] 575540003968 Flp/Fap pilin component; Region: Flp_Fap; cl01585 575540003969 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 575540003970 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 575540003971 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 575540003972 MASE1; Region: MASE1; cl17823 575540003973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540003974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540003975 dimer interface [polypeptide binding]; other site 575540003976 phosphorylation site [posttranslational modification] 575540003977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540003978 ATP binding site [chemical binding]; other site 575540003979 Mg2+ binding site [ion binding]; other site 575540003980 G-X-G motif; other site 575540003981 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540003982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540003983 active site 575540003984 phosphorylation site [posttranslational modification] 575540003985 intermolecular recognition site; other site 575540003986 dimerization interface [polypeptide binding]; other site 575540003987 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 575540003988 galactarate dehydratase; Region: galactar-dH20; TIGR03248 575540003989 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 575540003990 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 575540003991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540003992 dimer interface [polypeptide binding]; other site 575540003993 conserved gate region; other site 575540003994 putative PBP binding loops; other site 575540003995 ABC-ATPase subunit interface; other site 575540003996 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540003997 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 575540003998 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 575540003999 putative active site [active] 575540004000 Transmembrane proteins 14C; Region: Tmemb_14; pfam03647 575540004001 SOUL heme-binding protein; Region: SOUL; pfam04832 575540004002 DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796 575540004003 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 575540004004 active site 575540004005 primer binding site [nucleotide binding]; other site 575540004006 NTP binding site [chemical binding]; other site 575540004007 metal binding triad [ion binding]; metal-binding site 575540004008 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 575540004009 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 575540004010 active site 575540004011 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 575540004012 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 575540004013 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 575540004014 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 575540004015 active site 575540004016 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540004017 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540004018 catalytic residues [active] 575540004019 MutS domain III; Region: MutS_III; cl17822 575540004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540004021 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540004022 Walker A/P-loop; other site 575540004023 ATP binding site [chemical binding]; other site 575540004024 Q-loop/lid; other site 575540004025 ABC transporter signature motif; other site 575540004026 Walker B; other site 575540004027 D-loop; other site 575540004028 H-loop/switch region; other site 575540004029 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 575540004030 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 575540004031 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 575540004032 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 575540004033 dimer interface [polypeptide binding]; other site 575540004034 anticodon binding site; other site 575540004035 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 575540004036 homodimer interface [polypeptide binding]; other site 575540004037 motif 1; other site 575540004038 active site 575540004039 motif 2; other site 575540004040 GAD domain; Region: GAD; pfam02938 575540004041 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540004042 active site 575540004043 motif 3; other site 575540004044 Protein of unknown function (DUF524); Region: DUF524; pfam04411 575540004045 Intermediate filament protein; Region: Filament; pfam00038 575540004046 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 575540004047 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 575540004048 active site 575540004049 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 575540004050 putative active site [active] 575540004051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 575540004052 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 575540004053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540004054 Walker A/P-loop; other site 575540004055 ATP binding site [chemical binding]; other site 575540004056 Q-loop/lid; other site 575540004057 ABC transporter signature motif; other site 575540004058 Walker B; other site 575540004059 D-loop; other site 575540004060 H-loop/switch region; other site 575540004061 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 575540004062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540004063 Walker A/P-loop; other site 575540004064 ATP binding site [chemical binding]; other site 575540004065 Q-loop/lid; other site 575540004066 ABC transporter signature motif; other site 575540004067 Walker B; other site 575540004068 D-loop; other site 575540004069 H-loop/switch region; other site 575540004070 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 575540004071 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 575540004072 Uncharacterized conserved protein [Function unknown]; Region: COG1915 575540004073 homodimer interface [polypeptide binding]; other site 575540004074 cobalt transport protein CbiM; Validated; Region: PRK06265 575540004075 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 575540004076 PDGLE domain; Region: PDGLE; pfam13190 575540004077 Cobalt transport protein; Region: CbiQ; cl00463 575540004078 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 575540004079 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 575540004080 Walker A/P-loop; other site 575540004081 ATP binding site [chemical binding]; other site 575540004082 Q-loop/lid; other site 575540004083 ABC transporter signature motif; other site 575540004084 Walker B; other site 575540004085 D-loop; other site 575540004086 H-loop/switch region; other site 575540004087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540004088 short chain dehydrogenase; Provisional; Region: PRK08219 575540004089 NAD(P) binding site [chemical binding]; other site 575540004090 active site 575540004091 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540004092 Sulfatase; Region: Sulfatase; cl17466 575540004093 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 575540004094 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 575540004095 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 575540004096 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 575540004097 Surface antigen; Region: Bac_surface_Ag; pfam01103 575540004098 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 575540004099 NTPase; Region: NTPase_1; cl17478 575540004100 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540004101 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540004102 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540004103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 575540004104 classical (c) SDRs; Region: SDR_c; cd05233 575540004105 NAD(P) binding site [chemical binding]; other site 575540004106 active site 575540004107 Protein kinase domain; Region: Pkinase; pfam00069 575540004108 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004109 active site 575540004110 ATP binding site [chemical binding]; other site 575540004111 substrate binding site [chemical binding]; other site 575540004112 activation loop (A-loop); other site 575540004113 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004114 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004115 active site 575540004116 ATP binding site [chemical binding]; other site 575540004117 substrate binding site [chemical binding]; other site 575540004118 activation loop (A-loop); other site 575540004119 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 575540004120 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540004121 RNA binding surface [nucleotide binding]; other site 575540004122 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 575540004123 active site 575540004124 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 575540004125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004126 TPR motif; other site 575540004127 binding surface 575540004128 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540004129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004130 binding surface 575540004131 TPR motif; other site 575540004132 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 575540004133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004134 binding surface 575540004135 TPR motif; other site 575540004136 thiamine monophosphate kinase; Provisional; Region: PRK05731 575540004137 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 575540004138 ATP binding site [chemical binding]; other site 575540004139 dimerization interface [polypeptide binding]; other site 575540004140 glycerate kinase; Region: TIGR00045 575540004141 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540004142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540004143 active site 575540004144 phosphorylation site [posttranslational modification] 575540004145 intermolecular recognition site; other site 575540004146 dimerization interface [polypeptide binding]; other site 575540004147 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 575540004148 dimer interface [polypeptide binding]; other site 575540004149 phosphorylation site [posttranslational modification] 575540004150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540004151 ATP binding site [chemical binding]; other site 575540004152 Mg2+ binding site [ion binding]; other site 575540004153 G-X-G motif; other site 575540004154 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 575540004155 Predicted amidohydrolase [General function prediction only]; Region: COG0388 575540004156 multimer interface [polypeptide binding]; other site 575540004157 active site 575540004158 catalytic triad [active] 575540004159 protein interface 1 [polypeptide binding]; other site 575540004160 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 575540004161 Ligand Binding Site [chemical binding]; other site 575540004162 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 575540004163 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540004164 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540004165 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 575540004166 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 575540004167 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 575540004168 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 575540004169 hexamer interface [polypeptide binding]; other site 575540004170 ligand binding site [chemical binding]; other site 575540004171 putative active site [active] 575540004172 NAD(P) binding site [chemical binding]; other site 575540004173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 575540004174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 575540004175 active site 575540004176 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 575540004177 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 575540004178 NAD binding site [chemical binding]; other site 575540004179 substrate binding site [chemical binding]; other site 575540004180 homodimer interface [polypeptide binding]; other site 575540004181 active site 575540004182 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 575540004183 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 575540004184 substrate binding site; other site 575540004185 tetramer interface; other site 575540004186 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 575540004187 Response regulator receiver domain; Region: Response_reg; pfam00072 575540004188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540004189 active site 575540004190 phosphorylation site [posttranslational modification] 575540004191 intermolecular recognition site; other site 575540004192 dimerization interface [polypeptide binding]; other site 575540004193 L-lactate permease; Region: Lactate_perm; cl00701 575540004194 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 575540004195 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 575540004196 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 575540004197 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 575540004198 SprT-like family; Region: SprT-like; pfam10263 575540004199 glutathione synthetase; Provisional; Region: PRK05246 575540004200 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 575540004201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540004202 Predicted transcriptional regulators [Transcription]; Region: COG1510 575540004203 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 575540004204 Response regulator receiver domain; Region: Response_reg; pfam00072 575540004205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540004206 active site 575540004207 phosphorylation site [posttranslational modification] 575540004208 intermolecular recognition site; other site 575540004209 dimerization interface [polypeptide binding]; other site 575540004210 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540004211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540004212 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 575540004213 putative active site [active] 575540004214 heme pocket [chemical binding]; other site 575540004215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540004216 dimer interface [polypeptide binding]; other site 575540004217 phosphorylation site [posttranslational modification] 575540004218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540004219 ATP binding site [chemical binding]; other site 575540004220 G-X-G motif; other site 575540004221 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 575540004222 SurA N-terminal domain; Region: SurA_N_3; cl07813 575540004223 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 575540004224 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 575540004225 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540004226 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540004227 phosphopeptide binding site; other site 575540004228 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 575540004229 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 575540004230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540004231 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540004232 amino acid transporter; Region: 2A0306; TIGR00909 575540004233 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 575540004234 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 575540004235 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 575540004236 DEAD_2; Region: DEAD_2; pfam06733 575540004237 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 575540004238 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 575540004239 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 575540004240 putative active site [active] 575540004241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 575540004242 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 575540004243 active site 575540004244 catalytic tetrad [active] 575540004245 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 575540004246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 575540004247 active site 575540004248 Protein of unknown function (DUF971); Region: DUF971; pfam06155 575540004249 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540004250 HEAT repeats; Region: HEAT_2; pfam13646 575540004251 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540004252 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 575540004253 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540004254 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540004255 Sulfatase; Region: Sulfatase; pfam00884 575540004256 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 575540004257 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 575540004258 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 575540004259 purine nucleoside phosphorylase; Provisional; Region: PRK08202 575540004260 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 575540004261 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 575540004262 Nucleoside recognition; Region: Gate; pfam07670 575540004263 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 575540004264 dihydroorotase; Validated; Region: pyrC; PRK09357 575540004265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540004266 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 575540004267 active site 575540004268 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 575540004269 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 575540004270 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 575540004271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540004272 active site 575540004273 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 575540004274 Fasciclin domain; Region: Fasciclin; pfam02469 575540004275 FIST N domain; Region: FIST; pfam08495 575540004276 FIST C domain; Region: FIST_C; pfam10442 575540004277 Domain of unknown function DUF87; Region: DUF87; pfam01935 575540004278 AAA-like domain; Region: AAA_10; pfam12846 575540004279 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 575540004280 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 575540004281 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 575540004282 Walker A/P-loop; other site 575540004283 ATP binding site [chemical binding]; other site 575540004284 Q-loop/lid; other site 575540004285 ABC transporter signature motif; other site 575540004286 Walker B; other site 575540004287 D-loop; other site 575540004288 H-loop/switch region; other site 575540004289 TOBE-like domain; Region: TOBE_3; pfam12857 575540004290 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 575540004291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540004292 dimer interface [polypeptide binding]; other site 575540004293 conserved gate region; other site 575540004294 putative PBP binding loops; other site 575540004295 ABC-ATPase subunit interface; other site 575540004296 sulfate transport protein; Provisional; Region: cysT; CHL00187 575540004297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540004298 dimer interface [polypeptide binding]; other site 575540004299 conserved gate region; other site 575540004300 putative PBP binding loops; other site 575540004301 ABC-ATPase subunit interface; other site 575540004302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 575540004303 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 575540004304 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 575540004305 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 575540004306 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 575540004307 putative rRNA binding site [nucleotide binding]; other site 575540004308 aromatic acid decarboxylase; Validated; Region: PRK05920 575540004309 Flavoprotein; Region: Flavoprotein; pfam02441 575540004310 short chain dehydrogenase; Provisional; Region: PRK06181 575540004311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540004312 NAD(P) binding site [chemical binding]; other site 575540004313 active site 575540004314 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 575540004315 UbiA prenyltransferase family; Region: UbiA; pfam01040 575540004316 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 575540004317 xylose isomerase; Provisional; Region: PRK05474 575540004318 xylose isomerase; Region: xylose_isom_A; TIGR02630 575540004319 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 575540004320 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 575540004321 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 575540004322 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 575540004323 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 575540004324 XdhC Rossmann domain; Region: XdhC_C; pfam13478 575540004325 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 575540004326 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 575540004327 Ligand binding site; other site 575540004328 metal-binding site 575540004329 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 575540004330 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 575540004331 ATP binding site [chemical binding]; other site 575540004332 Mg++ binding site [ion binding]; other site 575540004333 motif III; other site 575540004334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540004335 nucleotide binding region [chemical binding]; other site 575540004336 ATP-binding site [chemical binding]; other site 575540004337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540004338 binding surface 575540004339 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540004340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004341 TPR motif; other site 575540004342 binding surface 575540004343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004344 TPR motif; other site 575540004345 binding surface 575540004346 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 575540004347 substrate binding site [chemical binding]; other site 575540004348 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 575540004349 4Fe-4S binding domain; Region: Fer4; cl02805 575540004350 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 575540004351 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 575540004352 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 575540004353 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 575540004354 putative RNA binding site [nucleotide binding]; other site 575540004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540004356 S-adenosylmethionine binding site [chemical binding]; other site 575540004357 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 575540004358 GTPase RsgA; Reviewed; Region: PRK00098 575540004359 RNA binding site [nucleotide binding]; other site 575540004360 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 575540004361 GTPase/Zn-binding domain interface [polypeptide binding]; other site 575540004362 GTP/Mg2+ binding site [chemical binding]; other site 575540004363 G4 box; other site 575540004364 G5 box; other site 575540004365 G1 box; other site 575540004366 Switch I region; other site 575540004367 G2 box; other site 575540004368 G3 box; other site 575540004369 Switch II region; other site 575540004370 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 575540004371 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 575540004372 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 575540004373 dimerization interface [polypeptide binding]; other site 575540004374 FAD binding pocket [chemical binding]; other site 575540004375 FAD binding motif [chemical binding]; other site 575540004376 catalytic residues [active] 575540004377 NAD binding pocket [chemical binding]; other site 575540004378 phosphate binding motif [ion binding]; other site 575540004379 beta-alpha-beta structure motif; other site 575540004380 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 575540004381 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 575540004382 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540004383 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 575540004384 von Willebrand factor type A domain; Region: VWA_2; pfam13519 575540004385 metal ion-dependent adhesion site (MIDAS); other site 575540004386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004387 TPR motif; other site 575540004388 binding surface 575540004389 hypothetical protein; Validated; Region: PRK00110 575540004390 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540004391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004392 TPR motif; other site 575540004393 binding surface 575540004394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004395 TPR motif; other site 575540004396 binding surface 575540004397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004398 TPR motif; other site 575540004399 binding surface 575540004400 TPR repeat; Region: TPR_11; pfam13414 575540004401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004402 TPR motif; other site 575540004403 binding surface 575540004404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540004405 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 575540004406 Fasciclin domain; Region: Fasciclin; pfam02469 575540004407 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 575540004408 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 575540004409 translation initiation factor IF-2; Region: IF-2; TIGR00487 575540004410 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 575540004411 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 575540004412 G1 box; other site 575540004413 putative GEF interaction site [polypeptide binding]; other site 575540004414 GTP/Mg2+ binding site [chemical binding]; other site 575540004415 Switch I region; other site 575540004416 G2 box; other site 575540004417 G3 box; other site 575540004418 Switch II region; other site 575540004419 G4 box; other site 575540004420 G5 box; other site 575540004421 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 575540004422 Translation-initiation factor 2; Region: IF-2; pfam11987 575540004423 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 575540004424 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 575540004425 NusA N-terminal domain; Region: NusA_N; pfam08529 575540004426 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 575540004427 RNA binding site [nucleotide binding]; other site 575540004428 homodimer interface [polypeptide binding]; other site 575540004429 NusA-like KH domain; Region: KH_5; pfam13184 575540004430 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 575540004431 G-X-X-G motif; other site 575540004432 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 575540004433 metal binding site 2 [ion binding]; metal-binding site 575540004434 putative DNA binding helix; other site 575540004435 metal binding site 1 [ion binding]; metal-binding site 575540004436 dimer interface [polypeptide binding]; other site 575540004437 structural Zn2+ binding site [ion binding]; other site 575540004438 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 575540004439 active site 575540004440 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540004441 structural tetrad; other site 575540004442 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540004443 WD domain, G-beta repeat; Region: WD40; pfam00400 575540004444 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540004445 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 575540004446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004448 active site 575540004449 ATP binding site [chemical binding]; other site 575540004450 substrate binding site [chemical binding]; other site 575540004451 activation loop (A-loop); other site 575540004452 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540004453 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540004454 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540004455 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540004456 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540004457 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 575540004458 iron-sulfur cluster [ion binding]; other site 575540004459 [2Fe-2S] cluster binding site [ion binding]; other site 575540004460 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 575540004461 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540004462 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 575540004463 Walker A/P-loop; other site 575540004464 ATP binding site [chemical binding]; other site 575540004465 Q-loop/lid; other site 575540004466 ABC transporter signature motif; other site 575540004467 Walker B; other site 575540004468 D-loop; other site 575540004469 H-loop/switch region; other site 575540004470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 575540004471 non-specific DNA binding site [nucleotide binding]; other site 575540004472 salt bridge; other site 575540004473 sequence-specific DNA binding site [nucleotide binding]; other site 575540004474 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 575540004475 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 575540004476 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 575540004477 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 575540004478 ADP-glucose phosphorylase; Region: PLN02643 575540004479 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 575540004480 nucleotide binding site/active site [active] 575540004481 HIT family signature motif; other site 575540004482 catalytic residue [active] 575540004483 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 575540004484 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 575540004485 active site 575540004486 catalytic site [active] 575540004487 homodimer interface [polypeptide binding]; other site 575540004488 Lid 1; other site 575540004489 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 575540004490 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 575540004491 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540004492 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 575540004493 RNA binding site [nucleotide binding]; other site 575540004494 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 575540004495 RNA binding site [nucleotide binding]; other site 575540004496 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 575540004497 RNA binding site [nucleotide binding]; other site 575540004498 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 575540004499 RNA binding site [nucleotide binding]; other site 575540004500 domain interface; other site 575540004501 CTP synthetase; Validated; Region: pyrG; PRK05380 575540004502 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 575540004503 Catalytic site [active] 575540004504 active site 575540004505 UTP binding site [chemical binding]; other site 575540004506 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 575540004507 active site 575540004508 putative oxyanion hole; other site 575540004509 catalytic triad [active] 575540004510 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 575540004511 active site 575540004512 catalytic triad [active] 575540004513 oxyanion hole [active] 575540004514 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540004515 Sulfatase; Region: Sulfatase; cl17466 575540004516 Sulfatase; Region: Sulfatase; cl17466 575540004517 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 575540004518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540004519 active site 575540004520 phosphorylation site [posttranslational modification] 575540004521 intermolecular recognition site; other site 575540004522 dimerization interface [polypeptide binding]; other site 575540004523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540004524 Zn2+ binding site [ion binding]; other site 575540004525 Mg2+ binding site [ion binding]; other site 575540004526 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 575540004527 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 575540004528 dimer interface [polypeptide binding]; other site 575540004529 putative functional site; other site 575540004530 putative MPT binding site; other site 575540004531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 575540004532 sequence-specific DNA binding site [nucleotide binding]; other site 575540004533 salt bridge; other site 575540004534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540004535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004536 active site 575540004537 ATP binding site [chemical binding]; other site 575540004538 substrate binding site [chemical binding]; other site 575540004539 activation loop (A-loop); other site 575540004540 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 575540004541 Nitrogen regulatory protein P-II; Region: P-II; smart00938 575540004542 Global regulator protein family; Region: CsrA; pfam02599 575540004543 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 575540004544 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 575540004545 active site lid residues [active] 575540004546 substrate binding pocket [chemical binding]; other site 575540004547 catalytic residues [active] 575540004548 substrate-Mg2+ binding site; other site 575540004549 aspartate-rich region 1; other site 575540004550 aspartate-rich region 2; other site 575540004551 phytoene desaturase; Region: crtI_fam; TIGR02734 575540004552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540004553 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 575540004554 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 575540004555 substrate binding pocket [chemical binding]; other site 575540004556 substrate-Mg2+ binding site; other site 575540004557 aspartate-rich region 1; other site 575540004558 aspartate-rich region 2; other site 575540004559 Domain of unknown function (DUF329); Region: DUF329; pfam03884 575540004560 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 575540004561 iron binding site [ion binding]; other site 575540004562 GrpE; Region: GrpE; pfam01025 575540004563 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 575540004564 dimer interface [polypeptide binding]; other site 575540004565 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 575540004566 chaperone protein DnaJ; Provisional; Region: PRK10767 575540004567 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 575540004568 HSP70 interaction site [polypeptide binding]; other site 575540004569 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 575540004570 substrate binding site [polypeptide binding]; other site 575540004571 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 575540004572 Zn binding sites [ion binding]; other site 575540004573 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 575540004574 dimer interface [polypeptide binding]; other site 575540004575 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 575540004576 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 575540004577 ring oligomerisation interface [polypeptide binding]; other site 575540004578 ATP/Mg binding site [chemical binding]; other site 575540004579 stacking interactions; other site 575540004580 hinge regions; other site 575540004581 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 575540004582 oligomerisation interface [polypeptide binding]; other site 575540004583 mobile loop; other site 575540004584 roof hairpin; other site 575540004585 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 575540004586 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 575540004587 ring oligomerisation interface [polypeptide binding]; other site 575540004588 ATP/Mg binding site [chemical binding]; other site 575540004589 stacking interactions; other site 575540004590 hinge regions; other site 575540004591 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540004592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540004593 S-adenosylmethionine binding site [chemical binding]; other site 575540004594 N-acetylneuraminate lyase; Provisional; Region: PRK04147 575540004595 Class I aldolases; Region: Aldolase_Class_I; cl17187 575540004596 catalytic residue [active] 575540004597 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 575540004598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540004599 S-adenosylmethionine binding site [chemical binding]; other site 575540004600 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 575540004601 Lumazine binding domain; Region: Lum_binding; pfam00677 575540004602 Lumazine binding domain; Region: Lum_binding; pfam00677 575540004603 membrane ATPase/protein kinase; Provisional; Region: PRK09435 575540004604 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 575540004605 Walker A; other site 575540004606 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 575540004607 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 575540004608 active site 575540004609 substrate binding site [chemical binding]; other site 575540004610 coenzyme B12 binding site [chemical binding]; other site 575540004611 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 575540004612 B12 binding site [chemical binding]; other site 575540004613 cobalt ligand [ion binding]; other site 575540004614 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 575540004615 heterodimer interface [polypeptide binding]; other site 575540004616 substrate interaction site [chemical binding]; other site 575540004617 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 575540004618 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 575540004619 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 575540004620 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 575540004621 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 575540004622 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 575540004623 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 575540004624 carboxyltransferase (CT) interaction site; other site 575540004625 biotinylation site [posttranslational modification]; other site 575540004626 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 575540004627 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 575540004628 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 575540004629 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 575540004630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 575540004631 dimer interface [polypeptide binding]; other site 575540004632 substrate binding site [chemical binding]; other site 575540004633 metal binding site [ion binding]; metal-binding site 575540004634 Uncharacterized conserved protein [Function unknown]; Region: COG3391 575540004635 Phosphoesterase family; Region: Phosphoesterase; pfam04185 575540004636 Outer membrane efflux protein; Region: OEP; pfam02321 575540004637 Outer membrane efflux protein; Region: OEP; pfam02321 575540004638 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 575540004639 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 575540004640 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 575540004641 active site 575540004642 dimer interface [polypeptide binding]; other site 575540004643 effector binding site; other site 575540004644 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 575540004645 TSCPD domain; Region: TSCPD; pfam12637 575540004646 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 575540004647 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 575540004648 rRNA interaction site [nucleotide binding]; other site 575540004649 S8 interaction site; other site 575540004650 putative laminin-1 binding site; other site 575540004651 elongation factor Ts; Provisional; Region: tsf; PRK09377 575540004652 Elongation factor TS; Region: EF_TS; pfam00889 575540004653 Elongation factor TS; Region: EF_TS; pfam00889 575540004654 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 575540004655 putative nucleotide binding site [chemical binding]; other site 575540004656 uridine monophosphate binding site [chemical binding]; other site 575540004657 homohexameric interface [polypeptide binding]; other site 575540004658 ribosome recycling factor; Reviewed; Region: frr; PRK00083 575540004659 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 575540004660 hinge region; other site 575540004661 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 575540004662 Moco binding site; other site 575540004663 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540004664 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004665 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004666 active site 575540004667 ATP binding site [chemical binding]; other site 575540004668 substrate binding site [chemical binding]; other site 575540004669 activation loop (A-loop); other site 575540004670 RDD family; Region: RDD; pfam06271 575540004671 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 575540004672 30S subunit binding site; other site 575540004673 Predicted transcriptional regulator [Transcription]; Region: COG2378 575540004674 Right handed beta helix region; Region: Beta_helix; pfam13229 575540004675 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 575540004676 metal binding site [ion binding]; metal-binding site 575540004677 ligand binding site [chemical binding]; other site 575540004678 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 575540004679 Interdomain contacts; other site 575540004680 Cytokine receptor motif; other site 575540004681 Pleckstrin homology-like domain; Region: PH-like; cl17171 575540004682 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 575540004683 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 575540004684 G1 box; other site 575540004685 putative GEF interaction site [polypeptide binding]; other site 575540004686 GTP/Mg2+ binding site [chemical binding]; other site 575540004687 Switch I region; other site 575540004688 G2 box; other site 575540004689 G3 box; other site 575540004690 Switch II region; other site 575540004691 G4 box; other site 575540004692 G5 box; other site 575540004693 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 575540004694 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 575540004695 BNR repeat-like domain; Region: BNR_2; pfam13088 575540004696 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 575540004697 Asp-box motif; other site 575540004698 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 575540004699 Calx-beta domain; Region: Calx-beta; pfam03160 575540004700 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 575540004701 Calx-beta domain; Region: Calx-beta; pfam03160 575540004702 Calx-beta domain; Region: Calx-beta; cl02522 575540004703 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 575540004704 Calx-beta domain; Region: Calx-beta; pfam03160 575540004705 Calx-beta domain; Region: Calx-beta; pfam03160 575540004706 Calx-beta domain; Region: Calx-beta; pfam03160 575540004707 Calx-beta domain; Region: Calx-beta; cl02522 575540004708 Calx-beta domain; Region: Calx-beta; pfam03160 575540004709 Calx-beta domain; Region: Calx-beta; pfam03160 575540004710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540004711 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 575540004712 NAD(P) binding site [chemical binding]; other site 575540004713 active site 575540004714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540004715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 575540004716 putative substrate translocation pore; other site 575540004717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540004718 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 575540004719 Cytochrome P450; Region: p450; cl12078 575540004720 Outer membrane efflux protein; Region: OEP; pfam02321 575540004721 Outer membrane efflux protein; Region: OEP; pfam02321 575540004722 MMPL family; Region: MMPL; pfam03176 575540004723 MMPL family; Region: MMPL; pfam03176 575540004724 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 575540004725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540004726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540004727 homodimer interface [polypeptide binding]; other site 575540004728 catalytic residue [active] 575540004729 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 575540004730 catalytic center binding site [active] 575540004731 ATP binding site [chemical binding]; other site 575540004732 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 575540004733 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 575540004734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 575540004735 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 575540004736 Propanediol utilisation protein PduL; Region: PduL; pfam06130 575540004737 Propanediol utilisation protein PduL; Region: PduL; pfam06130 575540004738 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 575540004739 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 575540004740 Hexamer interface [polypeptide binding]; other site 575540004741 Hexagonal pore residue; other site 575540004742 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 575540004743 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 575540004744 Hexamer interface [polypeptide binding]; other site 575540004745 Hexagonal pore residue; other site 575540004746 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 575540004747 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 575540004748 Hexamer interface [polypeptide binding]; other site 575540004749 Hexagonal pore residue; other site 575540004750 Acetokinase family; Region: Acetate_kinase; cl17229 575540004751 propionate/acetate kinase; Provisional; Region: PRK12379 575540004752 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 575540004753 Hexamer/Pentamer interface [polypeptide binding]; other site 575540004754 central pore; other site 575540004755 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 575540004756 NAD(P) binding site [chemical binding]; other site 575540004757 catalytic residues [active] 575540004758 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 575540004759 Hexamer/Pentamer interface [polypeptide binding]; other site 575540004760 central pore; other site 575540004761 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 575540004762 Hexamer/Pentamer interface [polypeptide binding]; other site 575540004763 central pore; other site 575540004764 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 575540004765 intersubunit interface [polypeptide binding]; other site 575540004766 active site 575540004767 Zn2+ binding site [ion binding]; other site 575540004768 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 575540004769 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 575540004770 NAD(P) binding site [chemical binding]; other site 575540004771 dimer interface [polypeptide binding]; other site 575540004772 tetramer (dimer of dimers) interface [polypeptide binding]; other site 575540004773 substrate binding site [chemical binding]; other site 575540004774 Class I aldolases; Region: Aldolase_Class_I; cl17187 575540004775 catalytic residue [active] 575540004776 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540004777 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004778 active site 575540004779 ATP binding site [chemical binding]; other site 575540004780 substrate binding site [chemical binding]; other site 575540004781 activation loop (A-loop); other site 575540004782 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540004783 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540004784 structural tetrad; other site 575540004785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004786 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004787 active site 575540004788 ATP binding site [chemical binding]; other site 575540004789 substrate binding site [chemical binding]; other site 575540004790 activation loop (A-loop); other site 575540004791 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540004792 structural tetrad; other site 575540004793 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540004794 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 575540004795 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 575540004796 inhibitor-cofactor binding pocket; inhibition site 575540004797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540004798 catalytic residue [active] 575540004799 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 575540004800 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 575540004801 minor groove reading motif; other site 575540004802 helix-hairpin-helix signature motif; other site 575540004803 substrate binding pocket [chemical binding]; other site 575540004804 active site 575540004805 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 575540004806 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 575540004807 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 575540004808 active site 575540004809 multimer interface [polypeptide binding]; other site 575540004810 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 575540004811 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 575540004812 active site residue [active] 575540004813 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540004814 protein binding site [polypeptide binding]; other site 575540004815 elongation factor G; Reviewed; Region: PRK00007 575540004816 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 575540004817 G1 box; other site 575540004818 putative GEF interaction site [polypeptide binding]; other site 575540004819 GTP/Mg2+ binding site [chemical binding]; other site 575540004820 Switch I region; other site 575540004821 G2 box; other site 575540004822 G3 box; other site 575540004823 Switch II region; other site 575540004824 G4 box; other site 575540004825 G5 box; other site 575540004826 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 575540004827 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 575540004828 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 575540004829 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 575540004830 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 575540004831 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 575540004832 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540004833 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540004834 Protein of unknown function (DUF721); Region: DUF721; pfam05258 575540004835 DNA topoisomerase II large subunit; Provisional; Region: 39; PHA02569 575540004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540004837 ATP binding site [chemical binding]; other site 575540004838 Mg2+ binding site [ion binding]; other site 575540004839 G-X-G motif; other site 575540004840 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 575540004841 anchoring element; other site 575540004842 dimer interface [polypeptide binding]; other site 575540004843 ATP binding site [chemical binding]; other site 575540004844 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 575540004845 active site 575540004846 putative metal-binding site [ion binding]; other site 575540004847 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 575540004848 SWIM zinc finger; Region: SWIM; pfam04434 575540004849 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 575540004850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540004851 ATP binding site [chemical binding]; other site 575540004852 putative Mg++ binding site [ion binding]; other site 575540004853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540004854 nucleotide binding region [chemical binding]; other site 575540004855 ATP-binding site [chemical binding]; other site 575540004856 phosphodiesterase YaeI; Provisional; Region: PRK11340 575540004857 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 575540004858 putative active site [active] 575540004859 putative metal binding site [ion binding]; other site 575540004860 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 575540004861 active site 575540004862 Zn binding site [ion binding]; other site 575540004863 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 575540004864 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540004865 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 575540004866 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 575540004867 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 575540004868 Protein export membrane protein; Region: SecD_SecF; cl14618 575540004869 Preprotein translocase subunit; Region: YajC; pfam02699 575540004870 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 575540004871 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 575540004872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004873 binding surface 575540004874 TPR motif; other site 575540004875 TPR repeat; Region: TPR_11; pfam13414 575540004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540004877 binding surface 575540004878 TPR motif; other site 575540004879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540004880 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 575540004881 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 575540004882 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004883 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004884 active site 575540004885 ATP binding site [chemical binding]; other site 575540004886 substrate binding site [chemical binding]; other site 575540004887 activation loop (A-loop); other site 575540004888 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 575540004889 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 575540004890 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540004891 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 575540004892 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 575540004893 C-terminal peptidase (prc); Region: prc; TIGR00225 575540004894 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 575540004895 protein binding site [polypeptide binding]; other site 575540004896 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 575540004897 Active site serine [active] 575540004898 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 575540004899 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540004900 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 575540004901 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 575540004902 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 575540004903 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540004904 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540004905 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540004906 Walker A/P-loop; other site 575540004907 ATP binding site [chemical binding]; other site 575540004908 Q-loop/lid; other site 575540004909 ABC transporter signature motif; other site 575540004910 Walker B; other site 575540004911 D-loop; other site 575540004912 H-loop/switch region; other site 575540004913 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 575540004914 metal binding site [ion binding]; metal-binding site 575540004915 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 575540004916 MPT binding site; other site 575540004917 trimer interface [polypeptide binding]; other site 575540004918 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540004919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540004920 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004921 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004922 active site 575540004923 ATP binding site [chemical binding]; other site 575540004924 substrate binding site [chemical binding]; other site 575540004925 activation loop (A-loop); other site 575540004926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540004927 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 575540004928 Walker A/P-loop; other site 575540004929 ATP binding site [chemical binding]; other site 575540004930 Q-loop/lid; other site 575540004931 ABC transporter signature motif; other site 575540004932 Walker B; other site 575540004933 D-loop; other site 575540004934 H-loop/switch region; other site 575540004935 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 575540004936 active site 575540004937 catalytic residues [active] 575540004938 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540004939 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540004940 active site 575540004941 ATP binding site [chemical binding]; other site 575540004942 substrate binding site [chemical binding]; other site 575540004943 activation loop (A-loop); other site 575540004944 Methyltransferase domain; Region: Methyltransf_11; pfam08241 575540004945 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 575540004946 ADP-ribose binding site [chemical binding]; other site 575540004947 dimer interface [polypeptide binding]; other site 575540004948 active site 575540004949 nudix motif; other site 575540004950 metal binding site [ion binding]; metal-binding site 575540004951 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 575540004952 CoA binding domain; Region: CoA_binding; pfam02629 575540004953 CoA-ligase; Region: Ligase_CoA; pfam00549 575540004954 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 575540004955 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 575540004956 CoA-ligase; Region: Ligase_CoA; pfam00549 575540004957 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 575540004958 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 575540004959 putative ADP-binding pocket [chemical binding]; other site 575540004960 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 575540004961 Domain of unknown function DUF20; Region: UPF0118; pfam01594 575540004962 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 575540004963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540004964 ATP binding site [chemical binding]; other site 575540004965 Mg2+ binding site [ion binding]; other site 575540004966 G-X-G motif; other site 575540004967 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 575540004968 ATP binding site [chemical binding]; other site 575540004969 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 575540004970 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 575540004971 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 575540004972 GTP1/OBG; Region: GTP1_OBG; pfam01018 575540004973 Obg GTPase; Region: Obg; cd01898 575540004974 G1 box; other site 575540004975 GTP/Mg2+ binding site [chemical binding]; other site 575540004976 Switch I region; other site 575540004977 G2 box; other site 575540004978 G3 box; other site 575540004979 Switch II region; other site 575540004980 G4 box; other site 575540004981 G5 box; other site 575540004982 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 575540004983 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 575540004984 Ligand Binding Site [chemical binding]; other site 575540004985 Leucine rich repeat; Region: LRR_8; pfam13855 575540004986 Leucine rich repeat; Region: LRR_8; pfam13855 575540004987 Leucine rich repeat; Region: LRR_8; pfam13855 575540004988 Leucine rich repeat; Region: LRR_8; pfam13855 575540004989 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 575540004990 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 575540004991 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 575540004992 active site 575540004993 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 575540004994 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 575540004995 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 575540004996 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 575540004997 active site 575540004998 trimer interface [polypeptide binding]; other site 575540004999 allosteric site; other site 575540005000 active site lid [active] 575540005001 TPR repeat; Region: TPR_11; pfam13414 575540005002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005003 TPR motif; other site 575540005004 binding surface 575540005005 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 575540005006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540005007 binding surface 575540005008 TPR motif; other site 575540005009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540005010 binding surface 575540005011 TPR motif; other site 575540005012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005013 binding surface 575540005014 TPR motif; other site 575540005015 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540005016 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540005017 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540005018 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540005019 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540005020 CAAX protease self-immunity; Region: Abi; pfam02517 575540005021 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 575540005022 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263 575540005023 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 575540005024 Walker A/P-loop; other site 575540005025 ATP binding site [chemical binding]; other site 575540005026 Q-loop/lid; other site 575540005027 ABC transporter signature motif; other site 575540005028 Walker B; other site 575540005029 D-loop; other site 575540005030 H-loop/switch region; other site 575540005031 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 575540005032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540005033 dimer interface [polypeptide binding]; other site 575540005034 conserved gate region; other site 575540005035 putative PBP binding loops; other site 575540005036 ABC-ATPase subunit interface; other site 575540005037 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 575540005038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540005039 dimer interface [polypeptide binding]; other site 575540005040 conserved gate region; other site 575540005041 putative PBP binding loops; other site 575540005042 ABC-ATPase subunit interface; other site 575540005043 PBP superfamily domain; Region: PBP_like_2; cl17296 575540005044 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 575540005045 DsrE/DsrF-like family; Region: DrsE; cl00672 575540005046 DsrE/DsrF-like family; Region: DrsE; cl00672 575540005047 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 575540005048 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 575540005049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005051 binding surface 575540005052 TPR motif; other site 575540005053 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 575540005054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540005055 FeS/SAM binding site; other site 575540005056 enolase; Provisional; Region: eno; PRK00077 575540005057 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 575540005058 dimer interface [polypeptide binding]; other site 575540005059 metal binding site [ion binding]; metal-binding site 575540005060 substrate binding pocket [chemical binding]; other site 575540005061 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540005062 catalytic core [active] 575540005063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540005064 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 575540005065 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 575540005066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 575540005067 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 575540005068 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 575540005069 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 575540005070 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 575540005071 CoA binding domain; Region: CoA_binding; pfam02629 575540005072 amino acid transporter; Region: 2A0306; TIGR00909 575540005073 HEAT-like repeat; Region: HEAT_EZ; pfam13513 575540005074 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 575540005075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005076 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005077 active site 575540005078 ATP binding site [chemical binding]; other site 575540005079 substrate binding site [chemical binding]; other site 575540005080 activation loop (A-loop); other site 575540005081 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 575540005082 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 575540005083 active site 575540005084 FMN binding site [chemical binding]; other site 575540005085 substrate binding site [chemical binding]; other site 575540005086 putative catalytic residue [active] 575540005087 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 575540005088 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 575540005089 Walker A/P-loop; other site 575540005090 ATP binding site [chemical binding]; other site 575540005091 Q-loop/lid; other site 575540005092 ABC transporter signature motif; other site 575540005093 Walker B; other site 575540005094 D-loop; other site 575540005095 H-loop/switch region; other site 575540005096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 575540005097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 575540005098 substrate binding pocket [chemical binding]; other site 575540005099 membrane-bound complex binding site; other site 575540005100 hinge residues; other site 575540005101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 575540005102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540005103 dimer interface [polypeptide binding]; other site 575540005104 conserved gate region; other site 575540005105 putative PBP binding loops; other site 575540005106 ABC-ATPase subunit interface; other site 575540005107 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 575540005108 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 575540005109 ligand binding site; other site 575540005110 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 575540005111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540005112 Walker A motif; other site 575540005113 ATP binding site [chemical binding]; other site 575540005114 Walker B motif; other site 575540005115 arginine finger; other site 575540005116 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 575540005117 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 575540005118 active site 575540005119 catalytic tetrad [active] 575540005120 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 575540005121 Carbon starvation protein CstA; Region: CstA; pfam02554 575540005122 Carbon starvation protein CstA; Region: CstA; pfam02554 575540005123 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 575540005124 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 575540005125 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 575540005126 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 575540005127 Permease; Region: Permease; pfam02405 575540005128 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 575540005129 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 575540005130 Walker A/P-loop; other site 575540005131 ATP binding site [chemical binding]; other site 575540005132 Q-loop/lid; other site 575540005133 ABC transporter signature motif; other site 575540005134 Walker B; other site 575540005135 D-loop; other site 575540005136 H-loop/switch region; other site 575540005137 mce related protein; Region: MCE; pfam02470 575540005138 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 575540005139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005140 binding surface 575540005141 TPR motif; other site 575540005142 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540005143 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540005144 active site 575540005145 metal binding site [ion binding]; metal-binding site 575540005146 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 575540005147 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 575540005148 putative ribose interaction site [chemical binding]; other site 575540005149 putative ADP binding site [chemical binding]; other site 575540005150 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 575540005151 active site 575540005152 nucleotide binding site [chemical binding]; other site 575540005153 HIGH motif; other site 575540005154 KMSKS motif; other site 575540005155 Predicted ATPase [General function prediction only]; Region: COG4637 575540005156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540005157 Walker B; other site 575540005158 D-loop; other site 575540005159 H-loop/switch region; other site 575540005160 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540005161 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540005162 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540005163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540005164 Uncharacterized conserved protein [Function unknown]; Region: COG3391 575540005165 NHL repeat; Region: NHL; pfam01436 575540005166 NHL repeat; Region: NHL; pfam01436 575540005167 Domain of unknown function DUF59; Region: DUF59; pfam01883 575540005168 antiporter inner membrane protein; Provisional; Region: PRK11670 575540005169 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 575540005170 Walker A motif; other site 575540005171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540005172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005173 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 575540005174 Peptidase family M50; Region: Peptidase_M50; pfam02163 575540005175 active site 575540005176 putative substrate binding region [chemical binding]; other site 575540005177 Putative phosphatase (DUF442); Region: DUF442; cl17385 575540005178 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 575540005179 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 575540005180 active site 575540005181 Uncharacterized conserved protein [Function unknown]; Region: COG0585 575540005182 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 575540005183 active site 575540005184 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 575540005185 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 575540005186 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 575540005187 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 575540005188 Peptidase family M28; Region: Peptidase_M28; pfam04389 575540005189 metal binding site [ion binding]; metal-binding site 575540005190 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 575540005191 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 575540005192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540005193 active site 575540005194 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 575540005195 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 575540005196 FMN binding site [chemical binding]; other site 575540005197 active site 575540005198 catalytic residues [active] 575540005199 substrate binding site [chemical binding]; other site 575540005200 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 575540005201 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 575540005202 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 575540005203 TPP-binding site; other site 575540005204 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 575540005205 PYR/PP interface [polypeptide binding]; other site 575540005206 dimer interface [polypeptide binding]; other site 575540005207 TPP binding site [chemical binding]; other site 575540005208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 575540005209 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 575540005210 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 575540005211 substrate binding pocket [chemical binding]; other site 575540005212 chain length determination region; other site 575540005213 substrate-Mg2+ binding site; other site 575540005214 catalytic residues [active] 575540005215 aspartate-rich region 1; other site 575540005216 active site lid residues [active] 575540005217 aspartate-rich region 2; other site 575540005218 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 575540005219 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 575540005220 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 575540005221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 575540005222 substrate binding site [chemical binding]; other site 575540005223 oxyanion hole (OAH) forming residues; other site 575540005224 trimer interface [polypeptide binding]; other site 575540005225 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 575540005226 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 575540005227 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 575540005228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540005229 putative active site [active] 575540005230 putative metal binding site [ion binding]; other site 575540005231 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 575540005232 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 575540005233 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 575540005234 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 575540005235 active site 575540005236 (T/H)XGH motif; other site 575540005237 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 575540005238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540005239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540005240 catalytic residue [active] 575540005241 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005242 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005243 Cna protein B-type domain; Region: Cna_B; pfam05738 575540005244 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005245 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005246 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005247 Cna protein B-type domain; Region: Cna_B; pfam05738 575540005248 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005249 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005250 Cna protein B-type domain; Region: Cna_B; pfam05738 575540005251 Cna protein B-type domain; Region: Cna_B; pfam05738 575540005252 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 575540005253 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 575540005254 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 575540005255 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 575540005256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540005257 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 575540005258 active site 575540005259 dimer interface [polypeptide binding]; other site 575540005260 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540005261 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540005262 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 575540005263 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540005264 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540005265 Right handed beta helix region; Region: Beta_helix; pfam13229 575540005266 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 575540005267 Right handed beta helix region; Region: Beta_helix; pfam13229 575540005268 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 575540005269 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 575540005270 putative active site [active] 575540005271 catalytic triad [active] 575540005272 Uncharacterized conserved protein [Function unknown]; Region: COG1432 575540005273 LabA_like proteins; Region: LabA_like; cd06167 575540005274 putative metal binding site [ion binding]; other site 575540005275 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 575540005276 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 575540005277 dimerization interface [polypeptide binding]; other site 575540005278 ATP binding site [chemical binding]; other site 575540005279 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 575540005280 dimerization interface [polypeptide binding]; other site 575540005281 ATP binding site [chemical binding]; other site 575540005282 prephenate dehydrogenase; Validated; Region: PRK08507 575540005283 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 575540005284 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 575540005285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540005286 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 575540005287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540005288 DNA binding residues [nucleotide binding] 575540005289 ribonuclease Y; Region: RNase_Y; TIGR03319 575540005290 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 575540005291 phosphopeptide binding site; other site 575540005292 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005294 active site 575540005295 ATP binding site [chemical binding]; other site 575540005296 substrate binding site [chemical binding]; other site 575540005297 activation loop (A-loop); other site 575540005298 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 575540005299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540005300 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 575540005301 active site 575540005302 dimer interface [polypeptide binding]; other site 575540005303 metal binding site [ion binding]; metal-binding site 575540005304 DNA protecting protein DprA; Region: dprA; TIGR00732 575540005305 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 575540005306 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540005307 active site 575540005308 ATP binding site [chemical binding]; other site 575540005309 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 575540005310 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 575540005311 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 575540005312 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 575540005313 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 575540005314 SmpB-tmRNA interface; other site 575540005315 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 575540005316 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 575540005317 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 575540005318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540005319 ATP binding site [chemical binding]; other site 575540005320 putative Mg++ binding site [ion binding]; other site 575540005321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540005322 nucleotide binding region [chemical binding]; other site 575540005323 ATP-binding site [chemical binding]; other site 575540005324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 575540005325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 575540005326 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 575540005327 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 575540005328 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 575540005329 Tetratricopeptide repeat; Region: TPR_6; pfam13174 575540005330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540005331 active site 575540005332 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 575540005333 phosphopeptide binding site; other site 575540005334 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 575540005335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 575540005336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 575540005337 dimer interface [polypeptide binding]; other site 575540005338 putative CheW interface [polypeptide binding]; other site 575540005339 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540005340 putative binding surface; other site 575540005341 active site 575540005342 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540005343 putative binding surface; other site 575540005344 active site 575540005345 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 575540005346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540005347 ATP binding site [chemical binding]; other site 575540005348 Mg2+ binding site [ion binding]; other site 575540005349 G-X-G motif; other site 575540005350 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 575540005351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005352 Response regulator receiver domain; Region: Response_reg; pfam00072 575540005353 active site 575540005354 phosphorylation site [posttranslational modification] 575540005355 intermolecular recognition site; other site 575540005356 dimerization interface [polypeptide binding]; other site 575540005357 Response regulator receiver domain; Region: Response_reg; pfam00072 575540005358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005359 active site 575540005360 phosphorylation site [posttranslational modification] 575540005361 intermolecular recognition site; other site 575540005362 dimerization interface [polypeptide binding]; other site 575540005363 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540005364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005365 active site 575540005366 phosphorylation site [posttranslational modification] 575540005367 intermolecular recognition site; other site 575540005368 dimerization interface [polypeptide binding]; other site 575540005369 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 575540005370 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540005371 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540005372 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 575540005373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540005374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 575540005375 dimerization interface [polypeptide binding]; other site 575540005376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540005377 dimer interface [polypeptide binding]; other site 575540005378 phosphorylation site [posttranslational modification] 575540005379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540005380 ATP binding site [chemical binding]; other site 575540005381 Mg2+ binding site [ion binding]; other site 575540005382 G-X-G motif; other site 575540005383 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 575540005384 nucleotide binding site [chemical binding]; other site 575540005385 putative NEF/HSP70 interaction site [polypeptide binding]; other site 575540005386 SBD interface [polypeptide binding]; other site 575540005387 DNA-K related protein; Region: DUF3731; pfam12531 575540005388 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540005389 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540005390 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540005391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 575540005392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 575540005393 active site 575540005394 metal binding site [ion binding]; metal-binding site 575540005395 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 575540005396 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540005397 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540005398 FeoA domain; Region: FeoA; cl00838 575540005399 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 575540005400 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 575540005401 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 575540005402 G1 box; other site 575540005403 GTP/Mg2+ binding site [chemical binding]; other site 575540005404 Switch I region; other site 575540005405 G2 box; other site 575540005406 G3 box; other site 575540005407 Switch II region; other site 575540005408 G4 box; other site 575540005409 G5 box; other site 575540005410 Nucleoside recognition; Region: Gate; pfam07670 575540005411 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 575540005412 Nucleoside recognition; Region: Gate; pfam07670 575540005413 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540005414 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 575540005415 oligomerization interface [polypeptide binding]; other site 575540005416 active site 575540005417 metal binding site [ion binding]; metal-binding site 575540005418 FAD binding domain; Region: FAD_binding_4; pfam01565 575540005419 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 575540005420 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540005421 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540005422 Walker A/P-loop; other site 575540005423 ATP binding site [chemical binding]; other site 575540005424 Q-loop/lid; other site 575540005425 ABC transporter signature motif; other site 575540005426 Walker B; other site 575540005427 D-loop; other site 575540005428 H-loop/switch region; other site 575540005429 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 575540005430 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 575540005431 TPR repeat; Region: TPR_11; pfam13414 575540005432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005433 binding surface 575540005434 TPR motif; other site 575540005435 TPR repeat; Region: TPR_11; pfam13414 575540005436 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540005437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005438 TPR motif; other site 575540005439 binding surface 575540005440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005441 TPR repeat; Region: TPR_11; pfam13414 575540005442 binding surface 575540005443 TPR motif; other site 575540005444 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 575540005445 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 575540005446 active site 575540005447 HIGH motif; other site 575540005448 dimer interface [polypeptide binding]; other site 575540005449 KMSKS motif; other site 575540005450 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 575540005451 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 575540005452 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 575540005453 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 575540005454 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 575540005455 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 575540005456 catalytic site [active] 575540005457 G-X2-G-X-G-K; other site 575540005458 hypothetical protein; Provisional; Region: PRK11820 575540005459 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 575540005460 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 575540005461 triosephosphate isomerase; Provisional; Region: PRK14567 575540005462 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 575540005463 substrate binding site [chemical binding]; other site 575540005464 dimer interface [polypeptide binding]; other site 575540005465 catalytic triad [active] 575540005466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005468 active site 575540005469 ATP binding site [chemical binding]; other site 575540005470 substrate binding site [chemical binding]; other site 575540005471 activation loop (A-loop); other site 575540005472 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005475 binding surface 575540005476 TPR motif; other site 575540005477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005479 binding surface 575540005480 TPR motif; other site 575540005481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005483 binding surface 575540005484 TPR motif; other site 575540005485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005488 binding surface 575540005489 TPR motif; other site 575540005490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540005493 binding surface 575540005494 TPR motif; other site 575540005495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540005496 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 575540005497 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 575540005498 Peptidase family M28; Region: Peptidase_M28; pfam04389 575540005499 metal binding site [ion binding]; metal-binding site 575540005500 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 575540005501 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 575540005502 putative active site [active] 575540005503 oxyanion strand; other site 575540005504 catalytic triad [active] 575540005505 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 575540005506 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 575540005507 catalytic residues [active] 575540005508 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 575540005509 elongation factor G; Reviewed; Region: PRK12740 575540005510 G1 box; other site 575540005511 putative GEF interaction site [polypeptide binding]; other site 575540005512 GTP/Mg2+ binding site [chemical binding]; other site 575540005513 Switch I region; other site 575540005514 G2 box; other site 575540005515 G3 box; other site 575540005516 Switch II region; other site 575540005517 G4 box; other site 575540005518 G5 box; other site 575540005519 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 575540005520 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 575540005521 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 575540005522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540005523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540005524 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 575540005525 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 575540005526 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 575540005527 dimerization interface [polypeptide binding]; other site 575540005528 active site 575540005529 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 575540005530 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540005531 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540005532 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 575540005533 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 575540005534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540005535 FeS/SAM binding site; other site 575540005536 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 575540005537 putative active site [active] 575540005538 putative metal binding residues [ion binding]; other site 575540005539 signature motif; other site 575540005540 putative triphosphate binding site [ion binding]; other site 575540005541 dimer interface [polypeptide binding]; other site 575540005542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 575540005543 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 575540005544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540005545 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 575540005546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540005547 DNA binding residues [nucleotide binding] 575540005548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005549 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540005550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005552 active site 575540005553 ATP binding site [chemical binding]; other site 575540005554 substrate binding site [chemical binding]; other site 575540005555 activation loop (A-loop); other site 575540005556 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540005557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540005559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005560 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 575540005561 putative ADP-binding pocket [chemical binding]; other site 575540005562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005563 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 575540005564 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 575540005565 putative metal binding site; other site 575540005566 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540005567 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540005568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540005569 Walker A/P-loop; other site 575540005570 ATP binding site [chemical binding]; other site 575540005571 Q-loop/lid; other site 575540005572 ABC transporter signature motif; other site 575540005573 Walker B; other site 575540005574 D-loop; other site 575540005575 H-loop/switch region; other site 575540005576 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 575540005577 active site 575540005578 catalytic triad [active] 575540005579 oxyanion hole [active] 575540005580 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540005581 HEAT repeats; Region: HEAT_2; pfam13646 575540005582 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540005583 Cytochrome c; Region: Cytochrom_C; pfam00034 575540005584 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540005585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540005586 active site 575540005587 metal binding site [ion binding]; metal-binding site 575540005588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540005589 Coenzyme A binding pocket [chemical binding]; other site 575540005590 hypothetical protein; Provisional; Region: PRK07338 575540005591 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 575540005592 metal binding site [ion binding]; metal-binding site 575540005593 dimer interface [polypeptide binding]; other site 575540005594 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 575540005595 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 575540005596 Cu(I) binding site [ion binding]; other site 575540005597 Protein of unknown function (DUF420); Region: DUF420; pfam04238 575540005598 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 575540005599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 575540005600 DNA binding residues [nucleotide binding] 575540005601 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 575540005602 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 575540005603 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 575540005604 four helix bundle protein; Region: TIGR02436 575540005605 5'-3' exonuclease; Region: 53EXOc; smart00475 575540005606 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 575540005607 active site 575540005608 metal binding site 1 [ion binding]; metal-binding site 575540005609 putative 5' ssDNA interaction site; other site 575540005610 metal binding site 3; metal-binding site 575540005611 metal binding site 2 [ion binding]; metal-binding site 575540005612 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 575540005613 putative DNA binding site [nucleotide binding]; other site 575540005614 putative metal binding site [ion binding]; other site 575540005615 DNA polymerase I; Provisional; Region: PRK05755 575540005616 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 575540005617 active site 575540005618 substrate binding site [chemical binding]; other site 575540005619 catalytic site [active] 575540005620 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 575540005621 active site 575540005622 DNA binding site [nucleotide binding] 575540005623 catalytic site [active] 575540005624 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 575540005625 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 575540005626 Citrate synthase; Region: Citrate_synt; pfam00285 575540005627 oxalacetate binding site [chemical binding]; other site 575540005628 citrylCoA binding site [chemical binding]; other site 575540005629 coenzyme A binding site [chemical binding]; other site 575540005630 catalytic triad [active] 575540005631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 575540005632 classical (c) SDRs; Region: SDR_c; cd05233 575540005633 NAD(P) binding site [chemical binding]; other site 575540005634 active site 575540005635 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540005636 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 575540005637 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540005638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540005639 S-adenosylmethionine binding site [chemical binding]; other site 575540005640 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 575540005641 GIY-YIG motif/motif A; other site 575540005642 active site 575540005643 catalytic site [active] 575540005644 putative DNA binding site [nucleotide binding]; other site 575540005645 metal binding site [ion binding]; metal-binding site 575540005646 UvrB/uvrC motif; Region: UVR; pfam02151 575540005647 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 575540005648 Methyltransferase domain; Region: Methyltransf_24; pfam13578 575540005649 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 575540005650 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540005651 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540005652 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540005653 phosphopeptide binding site; other site 575540005654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 575540005655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 575540005656 metal binding site [ion binding]; metal-binding site 575540005657 active site 575540005658 I-site; other site 575540005659 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 575540005660 dimer interface [polypeptide binding]; other site 575540005661 catalytic triad [active] 575540005662 peroxidatic and resolving cysteines [active] 575540005663 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 575540005664 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 575540005665 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 575540005666 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 575540005667 DNA binding residues [nucleotide binding] 575540005668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 575540005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005670 active site 575540005671 phosphorylation site [posttranslational modification] 575540005672 intermolecular recognition site; other site 575540005673 dimerization interface [polypeptide binding]; other site 575540005674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540005675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540005676 phosphorylation site [posttranslational modification] 575540005677 dimer interface [polypeptide binding]; other site 575540005678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 575540005679 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 575540005680 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 575540005681 CAAX protease self-immunity; Region: Abi; pfam02517 575540005682 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 575540005683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540005684 Walker A/P-loop; other site 575540005685 ATP binding site [chemical binding]; other site 575540005686 Q-loop/lid; other site 575540005687 ABC transporter signature motif; other site 575540005688 Walker B; other site 575540005689 D-loop; other site 575540005690 H-loop/switch region; other site 575540005691 CSL zinc finger; Region: zf-CSL; cl02163 575540005692 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 575540005693 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 575540005694 Ligand Binding Site [chemical binding]; other site 575540005695 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 575540005696 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 575540005697 NAD(P) binding site [chemical binding]; other site 575540005698 Putative phosphatase (DUF442); Region: DUF442; cl17385 575540005699 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540005700 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540005701 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540005702 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540005703 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 575540005704 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 575540005705 catalytic site [active] 575540005706 putative active site [active] 575540005707 putative substrate binding site [chemical binding]; other site 575540005708 HRDC domain; Region: HRDC; pfam00570 575540005709 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005710 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005711 active site 575540005712 ATP binding site [chemical binding]; other site 575540005713 substrate binding site [chemical binding]; other site 575540005714 activation loop (A-loop); other site 575540005715 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540005716 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540005717 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540005718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 575540005719 Domain of unknown function DUF21; Region: DUF21; pfam01595 575540005720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 575540005721 Transporter associated domain; Region: CorC_HlyC; smart01091 575540005722 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 575540005723 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 575540005724 intrachain domain interface; other site 575540005725 heme bH binding site [chemical binding]; other site 575540005726 heme bL binding site [chemical binding]; other site 575540005727 interchain domain interface [polypeptide binding]; other site 575540005728 Qo binding site; other site 575540005729 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 575540005730 intrachain domain interface; other site 575540005731 Qi binding site; other site 575540005732 Qo binding site; other site 575540005733 Cytochrome c; Region: Cytochrom_C; pfam00034 575540005734 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 575540005735 iron-sulfur cluster [ion binding]; other site 575540005736 [2Fe-2S] cluster binding site [ion binding]; other site 575540005737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540005738 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540005739 phosphopeptide binding site; other site 575540005740 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540005741 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540005742 phosphopeptide binding site; other site 575540005743 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 575540005744 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 575540005745 putative NADP binding site [chemical binding]; other site 575540005746 putative substrate binding site [chemical binding]; other site 575540005747 active site 575540005748 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540005749 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540005750 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540005751 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 575540005752 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 575540005753 motif 1; other site 575540005754 active site 575540005755 motif 2; other site 575540005756 motif 3; other site 575540005757 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 575540005758 DHHA1 domain; Region: DHHA1; pfam02272 575540005759 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 575540005760 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 575540005761 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 575540005762 putative RNA binding site [nucleotide binding]; other site 575540005763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540005764 S-adenosylmethionine binding site [chemical binding]; other site 575540005765 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 575540005766 recombinase A; Provisional; Region: recA; PRK09354 575540005767 hexamer interface [polypeptide binding]; other site 575540005768 Walker A motif; other site 575540005769 ATP binding site [chemical binding]; other site 575540005770 Walker B motif; other site 575540005771 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 575540005772 Predicted peptidase [General function prediction only]; Region: COG4099 575540005773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540005774 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 575540005775 active site 575540005776 motif I; other site 575540005777 motif II; other site 575540005778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540005779 Family description; Region: VCBS; pfam13517 575540005780 Family description; Region: VCBS; pfam13517 575540005781 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 575540005782 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 575540005783 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 575540005784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540005785 catalytic residue [active] 575540005786 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 575540005787 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 575540005788 trimerization site [polypeptide binding]; other site 575540005789 active site 575540005790 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 575540005791 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 575540005792 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 575540005793 Interdomain contacts; other site 575540005794 Cytokine receptor motif; other site 575540005795 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 575540005796 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 575540005797 dimer interface [polypeptide binding]; other site 575540005798 active site 575540005799 CoA binding pocket [chemical binding]; other site 575540005800 PAS fold; Region: PAS_3; pfam08447 575540005801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540005802 putative active site [active] 575540005803 PAS fold; Region: PAS_3; pfam08447 575540005804 heme pocket [chemical binding]; other site 575540005805 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 575540005806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540005807 dimer interface [polypeptide binding]; other site 575540005808 phosphorylation site [posttranslational modification] 575540005809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540005810 ATP binding site [chemical binding]; other site 575540005811 Mg2+ binding site [ion binding]; other site 575540005812 G-X-G motif; other site 575540005813 Response regulator receiver domain; Region: Response_reg; pfam00072 575540005814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005815 active site 575540005816 phosphorylation site [posttranslational modification] 575540005817 intermolecular recognition site; other site 575540005818 dimerization interface [polypeptide binding]; other site 575540005819 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540005820 putative binding surface; other site 575540005821 active site 575540005822 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 575540005823 Phage T7 capsid assembly protein; Region: Phage_T7_Capsid; cl14192 575540005824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005825 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540005826 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540005827 metal ion-dependent adhesion site (MIDAS); other site 575540005828 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 575540005829 metal binding site 2 [ion binding]; metal-binding site 575540005830 putative DNA binding helix; other site 575540005831 metal binding site 1 [ion binding]; metal-binding site 575540005832 dimer interface [polypeptide binding]; other site 575540005833 structural Zn2+ binding site [ion binding]; other site 575540005834 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 575540005835 Active_site [active] 575540005836 Domain of unknown function (DUF303); Region: DUF303; pfam03629 575540005837 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 575540005838 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 575540005839 active site 575540005840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540005841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540005842 catalytic residues [active] 575540005843 glycogen synthase; Provisional; Region: glgA; PRK00654 575540005844 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 575540005845 ADP-binding pocket [chemical binding]; other site 575540005846 homodimer interface [polypeptide binding]; other site 575540005847 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540005848 HEAT repeats; Region: HEAT_2; pfam13646 575540005849 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540005850 Cytochrome c; Region: Cytochrom_C; pfam00034 575540005851 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540005852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540005853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540005854 DNA binding residues [nucleotide binding] 575540005855 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 575540005856 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 575540005857 active site residue [active] 575540005858 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 575540005859 active site residue [active] 575540005860 Global regulator protein family; Region: CsrA; cl00670 575540005861 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 575540005862 FMN binding site [chemical binding]; other site 575540005863 substrate binding site [chemical binding]; other site 575540005864 putative catalytic residue [active] 575540005865 potential frameshift: common BLAST hit: gi|148264069|ref|YP_001230775.1| erythronolide synthase 575540005866 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 575540005867 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 575540005868 active site 575540005869 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 575540005870 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 575540005871 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 575540005872 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 575540005873 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 575540005874 putative NADP binding site [chemical binding]; other site 575540005875 active site 575540005876 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 575540005877 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 575540005878 active site 575540005879 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 575540005880 active site 575540005881 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 575540005882 Acyl transferase domain; Region: Acyl_transf_1; cl08282 575540005883 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 575540005884 active site 2 [active] 575540005885 dimer interface [polypeptide binding]; other site 575540005886 active site 1 [active] 575540005887 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 575540005888 active site 1 [active] 575540005889 dimer interface [polypeptide binding]; other site 575540005890 active site 2 [active] 575540005891 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 575540005892 active site 1 [active] 575540005893 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 575540005894 active site 2 [active] 575540005895 active site 1 [active] 575540005896 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 575540005897 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 575540005898 dimer interface [polypeptide binding]; other site 575540005899 active site 575540005900 CoA binding pocket [chemical binding]; other site 575540005901 haloalkane dehalogenase; Provisional; Region: PRK03592 575540005902 Uncharacterized conserved protein [Function unknown]; Region: COG3379 575540005903 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 575540005904 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 575540005905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540005906 putative substrate translocation pore; other site 575540005907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540005908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540005909 Sulfatase; Region: Sulfatase; pfam00884 575540005910 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 575540005911 Part of AAA domain; Region: AAA_19; pfam13245 575540005912 Family description; Region: UvrD_C_2; pfam13538 575540005913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540005914 Zn2+ binding site [ion binding]; other site 575540005915 Mg2+ binding site [ion binding]; other site 575540005916 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 575540005917 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 575540005918 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 575540005919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005920 active site 575540005921 ATP binding site [chemical binding]; other site 575540005922 substrate binding site [chemical binding]; other site 575540005923 activation loop (A-loop); other site 575540005924 Putative transcription activator [Transcription]; Region: TenA; COG0819 575540005925 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540005926 metal ion-dependent adhesion site (MIDAS); other site 575540005927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 575540005928 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 575540005929 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 575540005930 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 575540005931 dimer interface [polypeptide binding]; other site 575540005932 active site 575540005933 aspartate-rich active site metal binding site; other site 575540005934 allosteric magnesium binding site [ion binding]; other site 575540005935 Schiff base residues; other site 575540005936 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540005937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540005938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 575540005939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540005940 dimer interface [polypeptide binding]; other site 575540005941 phosphorylation site [posttranslational modification] 575540005942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540005943 ATP binding site [chemical binding]; other site 575540005944 Mg2+ binding site [ion binding]; other site 575540005945 G-X-G motif; other site 575540005946 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540005947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540005948 active site 575540005949 phosphorylation site [posttranslational modification] 575540005950 intermolecular recognition site; other site 575540005951 dimerization interface [polypeptide binding]; other site 575540005952 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540005953 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540005954 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 575540005955 dimer interface [polypeptide binding]; other site 575540005956 substrate binding site [chemical binding]; other site 575540005957 ATP binding site [chemical binding]; other site 575540005958 UvrB/uvrC motif; Region: UVR; pfam02151 575540005959 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 575540005960 putative active site [active] 575540005961 BNR repeat-like domain; Region: BNR_2; pfam13088 575540005962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 575540005963 classical (c) SDRs; Region: SDR_c; cd05233 575540005964 NAD(P) binding site [chemical binding]; other site 575540005965 active site 575540005966 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 575540005967 iron-sulfur cluster [ion binding]; other site 575540005968 [2Fe-2S] cluster binding site [ion binding]; other site 575540005969 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540005970 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540005971 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540005972 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540005973 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 575540005974 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 575540005975 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 575540005976 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 575540005977 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 575540005978 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540005979 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540005980 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540005981 phosphopeptide binding site; other site 575540005982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540005983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540005984 active site 575540005985 ATP binding site [chemical binding]; other site 575540005986 substrate binding site [chemical binding]; other site 575540005987 activation loop (A-loop); other site 575540005988 trehalose synthase; Region: treS_nterm; TIGR02456 575540005989 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 575540005990 active site 575540005991 catalytic site [active] 575540005992 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 575540005993 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 575540005994 HSP70 interaction site [polypeptide binding]; other site 575540005995 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 575540005996 substrate binding site [polypeptide binding]; other site 575540005997 dimer interface [polypeptide binding]; other site 575540005998 Ribonuclease P; Region: Ribonuclease_P; pfam00825 575540005999 Haemolytic domain; Region: Haemolytic; pfam01809 575540006000 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006001 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 575540006002 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 575540006003 active site 575540006004 Zn binding site [ion binding]; other site 575540006005 thioester reductase domain; Region: Thioester-redct; TIGR01746 575540006006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540006007 NAD(P) binding site [chemical binding]; other site 575540006008 active site 575540006009 GTP-binding protein YchF; Reviewed; Region: PRK09601 575540006010 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540006011 GTP/Mg2+ binding site [chemical binding]; other site 575540006012 Switch I region; other site 575540006013 G3 box; other site 575540006014 Switch II region; other site 575540006015 G4 box; other site 575540006016 G5 box; other site 575540006017 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 575540006018 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 575540006019 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 575540006020 active site 575540006021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540006022 active site 575540006023 gamma-glutamyl kinase; Provisional; Region: PRK05429 575540006024 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 575540006025 nucleotide binding site [chemical binding]; other site 575540006026 homotetrameric interface [polypeptide binding]; other site 575540006027 putative phosphate binding site [ion binding]; other site 575540006028 putative allosteric binding site; other site 575540006029 PUA domain; Region: PUA; pfam01472 575540006030 Colicin V production protein; Region: Colicin_V; pfam02674 575540006031 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 575540006032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540006033 NAD(P) binding site [chemical binding]; other site 575540006034 active site 575540006035 methionine aminopeptidase; Provisional; Region: PRK12318 575540006036 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 575540006037 active site 575540006038 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 575540006039 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 575540006040 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 575540006041 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 575540006042 active site residue [active] 575540006043 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 575540006044 active site residue [active] 575540006045 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 575540006046 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 575540006047 NADP binding site [chemical binding]; other site 575540006048 dimer interface [polypeptide binding]; other site 575540006049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006050 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 575540006051 DNA methylase; Region: N6_N4_Mtase; pfam01555 575540006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006053 S-adenosylmethionine binding site [chemical binding]; other site 575540006054 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006055 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540006056 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 575540006057 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 575540006058 active site 575540006059 TT viral orf 1; Region: TT_ORF1; pfam02956 575540006060 hypothetical protein; Provisional; Region: PRK04194 575540006061 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 575540006062 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 575540006063 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 575540006064 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 575540006065 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 575540006066 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 575540006067 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 575540006068 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 575540006069 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 575540006070 protein-rRNA interface [nucleotide binding]; other site 575540006071 putative translocon binding site; other site 575540006072 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 575540006073 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 575540006074 G-X-X-G motif; other site 575540006075 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 575540006076 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 575540006077 23S rRNA interface [nucleotide binding]; other site 575540006078 5S rRNA interface [nucleotide binding]; other site 575540006079 putative antibiotic binding site [chemical binding]; other site 575540006080 L25 interface [polypeptide binding]; other site 575540006081 L27 interface [polypeptide binding]; other site 575540006082 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 575540006083 23S rRNA interface [nucleotide binding]; other site 575540006084 putative translocon interaction site; other site 575540006085 signal recognition particle (SRP54) interaction site; other site 575540006086 L23 interface [polypeptide binding]; other site 575540006087 trigger factor interaction site; other site 575540006088 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 575540006089 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 575540006090 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 575540006091 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 575540006092 RNA binding site [nucleotide binding]; other site 575540006093 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 575540006094 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 575540006095 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 575540006096 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 575540006097 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 575540006098 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 575540006099 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 575540006100 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 575540006101 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 575540006102 5S rRNA interface [nucleotide binding]; other site 575540006103 23S rRNA interface [nucleotide binding]; other site 575540006104 L27 interface [polypeptide binding]; other site 575540006105 L5 interface [polypeptide binding]; other site 575540006106 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 575540006107 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 575540006108 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 575540006109 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 575540006110 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 575540006111 SecY translocase; Region: SecY; pfam00344 575540006112 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 575540006113 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 575540006114 30S ribosomal protein S13; Region: bact_S13; TIGR03631 575540006115 30S ribosomal protein S11; Validated; Region: PRK05309 575540006116 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 575540006117 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 575540006118 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540006119 RNA binding surface [nucleotide binding]; other site 575540006120 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 575540006121 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 575540006122 alphaNTD homodimer interface [polypeptide binding]; other site 575540006123 alphaNTD - beta interaction site [polypeptide binding]; other site 575540006124 alphaNTD - beta' interaction site [polypeptide binding]; other site 575540006125 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 575540006126 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 575540006127 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 575540006128 HIT family signature motif; other site 575540006129 catalytic residue [active] 575540006130 pyrroline-5-carboxylate reductase; Region: PLN02688 575540006131 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 575540006132 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 575540006133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540006134 NAD(P) binding site [chemical binding]; other site 575540006135 active site 575540006136 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 575540006137 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 575540006138 substrate binding site [chemical binding]; other site 575540006139 active site 575540006140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540006141 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540006142 Walker A/P-loop; other site 575540006143 ATP binding site [chemical binding]; other site 575540006144 Q-loop/lid; other site 575540006145 ABC transporter signature motif; other site 575540006146 Walker B; other site 575540006147 D-loop; other site 575540006148 H-loop/switch region; other site 575540006149 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 575540006150 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 575540006151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540006152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540006153 Walker A/P-loop; other site 575540006154 ATP binding site [chemical binding]; other site 575540006155 Q-loop/lid; other site 575540006156 ABC transporter signature motif; other site 575540006157 Walker B; other site 575540006158 D-loop; other site 575540006159 H-loop/switch region; other site 575540006160 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 575540006161 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 575540006162 Uncharacterized conserved protein [Function unknown]; Region: COG3937 575540006163 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 575540006164 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 575540006165 tandem repeat interface [polypeptide binding]; other site 575540006166 oligomer interface [polypeptide binding]; other site 575540006167 active site residues [active] 575540006168 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540006169 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 575540006170 FtsX-like permease family; Region: FtsX; pfam02687 575540006171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540006172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540006173 Walker A/P-loop; other site 575540006174 ATP binding site [chemical binding]; other site 575540006175 Q-loop/lid; other site 575540006176 ABC transporter signature motif; other site 575540006177 Walker B; other site 575540006178 D-loop; other site 575540006179 H-loop/switch region; other site 575540006180 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540006181 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 575540006182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540006183 Zn2+ binding site [ion binding]; other site 575540006184 Mg2+ binding site [ion binding]; other site 575540006185 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006186 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 575540006187 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 575540006188 Walker A/P-loop; other site 575540006189 ATP binding site [chemical binding]; other site 575540006190 Q-loop/lid; other site 575540006191 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 575540006192 ABC transporter signature motif; other site 575540006193 Walker B; other site 575540006194 D-loop; other site 575540006195 H-loop/switch region; other site 575540006196 methionine sulfoxide reductase B; Provisional; Region: PRK00222 575540006197 SelR domain; Region: SelR; pfam01641 575540006198 PQQ-like domain; Region: PQQ_2; pfam13360 575540006199 Outer membrane efflux protein; Region: OEP; pfam02321 575540006200 Outer membrane efflux protein; Region: OEP; pfam02321 575540006201 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 575540006202 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 575540006203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540006204 catalytic residue [active] 575540006205 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 575540006206 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 575540006207 dimer interface [polypeptide binding]; other site 575540006208 active site 575540006209 glycine-pyridoxal phosphate binding site [chemical binding]; other site 575540006210 folate binding site [chemical binding]; other site 575540006211 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540006212 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 575540006213 Protein kinase domain; Region: Pkinase; pfam00069 575540006214 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006215 active site 575540006216 ATP binding site [chemical binding]; other site 575540006217 substrate binding site [chemical binding]; other site 575540006218 activation loop (A-loop); other site 575540006219 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006220 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006221 active site 575540006222 ATP binding site [chemical binding]; other site 575540006223 substrate binding site [chemical binding]; other site 575540006224 activation loop (A-loop); other site 575540006225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540006226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006227 TPR motif; other site 575540006228 binding surface 575540006229 GH3 auxin-responsive promoter; Region: GH3; pfam03321 575540006230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006231 S-adenosylmethionine binding site [chemical binding]; other site 575540006232 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 575540006233 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 575540006234 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 575540006235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540006236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540006237 ABC transporter; Region: ABC_tran_2; pfam12848 575540006238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540006239 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 575540006240 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 575540006241 DNA polymerase III subunit beta; Validated; Region: PRK05643 575540006242 putative DNA binding surface [nucleotide binding]; other site 575540006243 dimer interface [polypeptide binding]; other site 575540006244 beta-clamp/clamp loader binding surface; other site 575540006245 beta-clamp/translesion DNA polymerase binding surface; other site 575540006246 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 575540006247 CRISPR-associated protein; Region: DUF3692; pfam12469 575540006248 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 575540006249 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 575540006250 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 575540006251 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 575540006252 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 575540006253 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 575540006254 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 575540006255 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 575540006256 putative NAD(P) binding site [chemical binding]; other site 575540006257 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 575540006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540006260 TPR repeat; Region: TPR_11; pfam13414 575540006261 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 575540006262 AhpC/TSA family; Region: AhpC-TSA; pfam00578 575540006263 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540006264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006266 active site 575540006267 ATP binding site [chemical binding]; other site 575540006268 substrate binding site [chemical binding]; other site 575540006269 activation loop (A-loop); other site 575540006270 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540006271 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540006272 GAF domain; Region: GAF_3; pfam13492 575540006273 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540006274 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 575540006275 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540006276 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540006277 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540006278 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 575540006279 Peptidase family M50; Region: Peptidase_M50; pfam02163 575540006280 active site 575540006281 putative substrate binding region [chemical binding]; other site 575540006282 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540006283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540006284 Uncharacterized conserved protein [Function unknown]; Region: COG1432 575540006285 LabA_like proteins; Region: LabA_like; cd06167 575540006286 putative metal binding site [ion binding]; other site 575540006287 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 575540006288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540006289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 575540006290 active site 575540006291 metal binding site [ion binding]; metal-binding site 575540006292 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 575540006293 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 575540006294 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 575540006295 active site 575540006296 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 575540006297 carboxyltransferase (CT) interaction site; other site 575540006298 biotinylation site [posttranslational modification]; other site 575540006299 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 575540006300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 575540006301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540006302 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 575540006303 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 575540006304 ligand binding site [chemical binding]; other site 575540006305 active site 575540006306 UGI interface [polypeptide binding]; other site 575540006307 catalytic site [active] 575540006308 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 575540006309 GSH binding site [chemical binding]; other site 575540006310 catalytic residues [active] 575540006311 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 575540006312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 575540006313 catalytic loop [active] 575540006314 iron binding site [ion binding]; other site 575540006315 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 575540006316 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 575540006317 [4Fe-4S] binding site [ion binding]; other site 575540006318 molybdopterin cofactor binding site; other site 575540006319 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 575540006320 molybdopterin cofactor binding site; other site 575540006321 Protein of unknown function (DUF556); Region: DUF556; cl00822 575540006322 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540006323 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 575540006324 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 575540006325 Predicted oxidoreductase [General function prediction only]; Region: COG3573 575540006326 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 575540006327 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 575540006328 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 575540006329 active site 575540006330 dimer interface [polypeptide binding]; other site 575540006331 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 575540006332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006333 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006334 active site 575540006335 ATP binding site [chemical binding]; other site 575540006336 substrate binding site [chemical binding]; other site 575540006337 activation loop (A-loop); other site 575540006338 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540006339 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 575540006340 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540006341 metal ion-dependent adhesion site (MIDAS); other site 575540006342 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 575540006343 PASTA domain; Region: PASTA; pfam03793 575540006344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 575540006345 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006346 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006347 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006348 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 575540006349 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006350 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006351 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006352 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 575540006353 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540006354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540006355 catalytic residues [active] 575540006356 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540006357 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540006358 catalytic residues [active] 575540006359 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 575540006360 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 575540006361 active site 575540006362 HIGH motif; other site 575540006363 nucleotide binding site [chemical binding]; other site 575540006364 active site 575540006365 KMSKS motif; other site 575540006366 peptide chain release factor 2; Provisional; Region: PRK05589 575540006367 This domain is found in peptide chain release factors; Region: PCRF; smart00937 575540006368 RF-1 domain; Region: RF-1; pfam00472 575540006369 Predicted amidohydrolase [General function prediction only]; Region: COG0388 575540006370 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 575540006371 active site 575540006372 catalytic triad [active] 575540006373 dimer interface [polypeptide binding]; other site 575540006374 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540006375 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 575540006376 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540006377 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540006378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006379 Uncharacterized conserved protein [Function unknown]; Region: COG3379 575540006380 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 575540006381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540006382 putative substrate translocation pore; other site 575540006383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540006384 PGAP1-like protein; Region: PGAP1; pfam07819 575540006385 hypothetical protein; Provisional; Region: PRK11281 575540006386 thymidylate synthase; Reviewed; Region: thyA; PRK01827 575540006387 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 575540006388 dimerization interface [polypeptide binding]; other site 575540006389 active site 575540006390 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006391 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 575540006392 active site 575540006393 catalytic residues [active] 575540006394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 575540006395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 575540006396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 575540006397 dimerization interface [polypeptide binding]; other site 575540006398 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 575540006399 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 575540006400 active site 575540006401 dimer interface [polypeptide binding]; other site 575540006402 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 575540006403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 575540006404 active site 575540006405 FMN binding site [chemical binding]; other site 575540006406 substrate binding site [chemical binding]; other site 575540006407 3Fe-4S cluster binding site [ion binding]; other site 575540006408 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 575540006409 domain interface; other site 575540006410 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 575540006411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 575540006412 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006413 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006414 active site 575540006415 ATP binding site [chemical binding]; other site 575540006416 substrate binding site [chemical binding]; other site 575540006417 activation loop (A-loop); other site 575540006418 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 575540006419 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 575540006420 V4R domain; Region: V4R; cl15268 575540006421 Phycobilisome protein; Region: Phycobilisome; cl08227 575540006422 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 575540006423 V4R domain; Region: V4R; pfam02830 575540006424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 575540006425 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 575540006426 catalytic loop [active] 575540006427 iron binding site [ion binding]; other site 575540006428 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 575540006429 heme binding pocket [chemical binding]; other site 575540006430 heme ligand [chemical binding]; other site 575540006431 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006432 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006433 active site 575540006434 ATP binding site [chemical binding]; other site 575540006435 substrate binding site [chemical binding]; other site 575540006436 activation loop (A-loop); other site 575540006437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006438 active site 575540006439 ATP binding site [chemical binding]; other site 575540006440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006441 substrate binding site [chemical binding]; other site 575540006442 activation loop (A-loop); other site 575540006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540006444 D-galactonate transporter; Region: 2A0114; TIGR00893 575540006445 putative substrate translocation pore; other site 575540006446 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 575540006447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540006448 putative active site [active] 575540006449 heme pocket [chemical binding]; other site 575540006450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540006451 dimer interface [polypeptide binding]; other site 575540006452 phosphorylation site [posttranslational modification] 575540006453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540006454 ATP binding site [chemical binding]; other site 575540006455 Mg2+ binding site [ion binding]; other site 575540006456 G-X-G motif; other site 575540006457 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 575540006458 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 575540006459 trimer interface [polypeptide binding]; other site 575540006460 putative metal binding site [ion binding]; other site 575540006461 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 575540006462 Zn binding site [ion binding]; other site 575540006463 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 575540006464 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540006465 Walker A/P-loop; other site 575540006466 ATP binding site [chemical binding]; other site 575540006467 Q-loop/lid; other site 575540006468 ABC transporter signature motif; other site 575540006469 Walker B; other site 575540006470 D-loop; other site 575540006471 H-loop/switch region; other site 575540006472 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 575540006473 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 575540006474 Ligand binding site; other site 575540006475 Putative Catalytic site; other site 575540006476 DXD motif; other site 575540006477 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 575540006478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540006479 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540006480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006481 TPR motif; other site 575540006482 binding surface 575540006483 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540006484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540006485 TPR motif; other site 575540006486 binding surface 575540006487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006488 TPR motif; other site 575540006489 binding surface 575540006490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006491 TPR motif; other site 575540006492 binding surface 575540006493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006494 binding surface 575540006495 TPR motif; other site 575540006496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006497 TPR motif; other site 575540006498 binding surface 575540006499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006500 binding surface 575540006501 TPR motif; other site 575540006502 TPR repeat; Region: TPR_11; pfam13414 575540006503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540006504 TPR motif; other site 575540006505 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 575540006506 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 575540006507 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 575540006508 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 575540006509 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 575540006510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 575540006511 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 575540006512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540006513 Walker A motif; other site 575540006514 ATP binding site [chemical binding]; other site 575540006515 Walker B motif; other site 575540006516 arginine finger; other site 575540006517 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540006518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006519 S-adenosylmethionine binding site [chemical binding]; other site 575540006520 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 575540006521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 575540006522 catalytic residues [active] 575540006523 Isochorismatase family; Region: Isochorismatase; pfam00857 575540006524 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 575540006525 catalytic triad [active] 575540006526 conserved cis-peptide bond; other site 575540006527 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 575540006528 PQQ-like domain; Region: PQQ_2; pfam13360 575540006529 Trp docking motif [polypeptide binding]; other site 575540006530 active site 575540006531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 575540006532 metal binding site [ion binding]; metal-binding site 575540006533 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 575540006534 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 575540006535 active site 575540006536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540006537 Haem-binding domain; Region: Haem_bd; pfam14376 575540006538 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 575540006539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 575540006540 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 575540006541 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 575540006542 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 575540006543 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 575540006544 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 575540006545 dihydrodipicolinate reductase; Provisional; Region: PRK00048 575540006546 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 575540006547 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 575540006548 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 575540006549 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 575540006550 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 575540006551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 575540006552 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 575540006553 Uncharacterized conserved protein [Function unknown]; Region: COG2308 575540006554 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540006555 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 575540006556 NAD binding site [chemical binding]; other site 575540006557 putative substrate binding site 2 [chemical binding]; other site 575540006558 putative substrate binding site 1 [chemical binding]; other site 575540006559 active site 575540006560 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 575540006561 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 575540006562 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 575540006563 Protein of unknown function (DUF423); Region: DUF423; pfam04241 575540006564 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 575540006565 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 575540006566 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 575540006567 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 575540006568 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 575540006569 putative active site [active] 575540006570 substrate binding site [chemical binding]; other site 575540006571 putative cosubstrate binding site; other site 575540006572 catalytic site [active] 575540006573 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 575540006574 substrate binding site [chemical binding]; other site 575540006575 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 575540006576 active site 575540006577 catalytic residues [active] 575540006578 metal binding site [ion binding]; metal-binding site 575540006579 BNR repeat-like domain; Region: BNR_2; pfam13088 575540006580 aminoacyl-tRNA ligase; Region: PLN02563 575540006581 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 575540006582 HIGH motif; other site 575540006583 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 575540006584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 575540006585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 575540006586 active site 575540006587 KMSKS motif; other site 575540006588 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 575540006589 tRNA binding surface [nucleotide binding]; other site 575540006590 BON domain; Region: BON; pfam04972 575540006591 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 575540006592 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 575540006593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540006594 FeS/SAM binding site; other site 575540006595 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 575540006596 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 575540006597 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 575540006598 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 575540006599 MgtE intracellular N domain; Region: MgtE_N; smart00924 575540006600 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 575540006601 Divalent cation transporter; Region: MgtE; pfam01769 575540006602 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 575540006603 NHL repeat; Region: NHL; pfam01436 575540006604 Methyltransferase domain; Region: Methyltransf_24; pfam13578 575540006605 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 575540006606 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540006607 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 575540006608 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 575540006609 dimer interface [polypeptide binding]; other site 575540006610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540006611 catalytic residue [active] 575540006612 Methyltransferase domain; Region: Methyltransf_26; pfam13659 575540006613 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 575540006614 MPN+ (JAMM) motif; other site 575540006615 Zinc-binding site [ion binding]; other site 575540006616 adenylate kinase; Region: adk; TIGR01351 575540006617 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 575540006618 AMP-binding site [chemical binding]; other site 575540006619 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 575540006620 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540006621 catalytic core [active] 575540006622 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 575540006623 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 575540006624 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 575540006625 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 575540006626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540006627 FeS/SAM binding site; other site 575540006628 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 575540006629 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 575540006630 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 575540006631 metal binding triad; other site 575540006632 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 575540006633 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 575540006634 metal binding triad; other site 575540006635 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 575540006636 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 575540006637 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 575540006638 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 575540006639 Peptidase family M28; Region: Peptidase_M28; pfam04389 575540006640 metal binding site [ion binding]; metal-binding site 575540006641 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540006642 protein binding site [polypeptide binding]; other site 575540006643 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540006644 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 575540006645 Leucine-rich repeats; other site 575540006646 Substrate binding site [chemical binding]; other site 575540006647 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540006648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006649 S-adenosylmethionine binding site [chemical binding]; other site 575540006650 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540006651 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 575540006652 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 575540006653 generic binding surface II; other site 575540006654 generic binding surface I; other site 575540006655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540006656 Zn2+ binding site [ion binding]; other site 575540006657 Mg2+ binding site [ion binding]; other site 575540006658 ribonuclease R; Region: RNase_R; TIGR02063 575540006659 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 575540006660 RNB domain; Region: RNB; pfam00773 575540006661 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 575540006662 RNA binding site [nucleotide binding]; other site 575540006663 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540006664 PEGA domain; Region: PEGA; pfam08308 575540006665 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 575540006666 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 575540006667 active site 575540006668 catalytic triad [active] 575540006669 dimer interface [polypeptide binding]; other site 575540006670 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 575540006671 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 575540006672 active site 575540006673 dimer interface [polypeptide binding]; other site 575540006674 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 575540006675 Ligand Binding Site [chemical binding]; other site 575540006676 Molecular Tunnel; other site 575540006677 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 575540006678 FliP family; Region: FliP; pfam00813 575540006679 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 575540006680 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 575540006681 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 575540006682 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 575540006683 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540006684 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 575540006685 FtsX-like permease family; Region: FtsX; pfam02687 575540006686 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540006687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540006688 Walker A/P-loop; other site 575540006689 ATP binding site [chemical binding]; other site 575540006690 Q-loop/lid; other site 575540006691 ABC transporter signature motif; other site 575540006692 Walker B; other site 575540006693 D-loop; other site 575540006694 H-loop/switch region; other site 575540006695 HlyD family secretion protein; Region: HlyD_2; pfam12700 575540006696 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540006697 Outer membrane efflux protein; Region: OEP; pfam02321 575540006698 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 575540006699 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 575540006700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540006701 S-adenosylmethionine binding site [chemical binding]; other site 575540006702 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540006703 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540006704 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 575540006705 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540006706 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540006707 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540006708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540006709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540006710 Acyltransferase family; Region: Acyl_transf_3; pfam01757 575540006711 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 575540006712 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 575540006713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540006714 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540006715 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540006716 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540006717 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540006718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540006719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540006720 DNA binding residues [nucleotide binding] 575540006721 Putative zinc-finger; Region: zf-HC2; pfam13490 575540006722 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 575540006723 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 575540006724 inhibitor-cofactor binding pocket; inhibition site 575540006725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540006726 catalytic residue [active] 575540006727 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 575540006728 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540006729 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 575540006730 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 575540006731 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540006732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540006733 Walker A motif; other site 575540006734 ATP binding site [chemical binding]; other site 575540006735 Walker B motif; other site 575540006736 arginine finger; other site 575540006737 Response regulator receiver domain; Region: Response_reg; pfam00072 575540006738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540006739 active site 575540006740 phosphorylation site [posttranslational modification] 575540006741 intermolecular recognition site; other site 575540006742 dimerization interface [polypeptide binding]; other site 575540006743 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 575540006744 DHH family; Region: DHH; pfam01368 575540006745 DHHA1 domain; Region: DHHA1; pfam02272 575540006746 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 575540006747 putative ligand binding site [chemical binding]; other site 575540006748 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 575540006749 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 575540006750 ligand binding site; other site 575540006751 oligomer interface; other site 575540006752 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 575540006753 dimer interface [polypeptide binding]; other site 575540006754 N-terminal domain interface [polypeptide binding]; other site 575540006755 sulfate 1 binding site; other site 575540006756 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 575540006757 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 575540006758 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006759 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006760 active site 575540006761 ATP binding site [chemical binding]; other site 575540006762 substrate binding site [chemical binding]; other site 575540006763 activation loop (A-loop); other site 575540006764 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 575540006765 putative acyl-acceptor binding pocket; other site 575540006766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 575540006767 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 575540006768 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 575540006769 putative dimer interface [polypeptide binding]; other site 575540006770 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 575540006771 putative active site [active] 575540006772 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 575540006773 putative active site [active] 575540006774 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 575540006775 putative active site [active] 575540006776 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540006777 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 575540006778 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 575540006779 heme-binding residues [chemical binding]; other site 575540006780 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 575540006781 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 575540006782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540006783 FeS/SAM binding site; other site 575540006784 HemN C-terminal domain; Region: HemN_C; pfam06969 575540006785 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 575540006786 active site 575540006787 8-oxo-dGMP binding site [chemical binding]; other site 575540006788 nudix motif; other site 575540006789 metal binding site [ion binding]; metal-binding site 575540006790 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 575540006791 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 575540006792 NAD binding site [chemical binding]; other site 575540006793 homotetramer interface [polypeptide binding]; other site 575540006794 homodimer interface [polypeptide binding]; other site 575540006795 substrate binding site [chemical binding]; other site 575540006796 active site 575540006797 Dockerin type I repeat; Region: Dockerin_1; pfam00404 575540006798 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540006799 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 575540006800 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 575540006801 Magnesium ion binding site [ion binding]; other site 575540006802 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 575540006803 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540006804 putative catalytic residue [active] 575540006805 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540006806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540006807 catalytic residues [active] 575540006808 Trehalose utilisation; Region: ThuA; pfam06283 575540006809 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540006810 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540006811 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 575540006812 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540006813 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540006814 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540006815 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540006816 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 575540006817 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 575540006818 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 575540006819 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 575540006820 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 575540006821 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 575540006822 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 575540006823 putative acyl-acceptor binding pocket; other site 575540006824 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 575540006825 nucleotide binding site [chemical binding]; other site 575540006826 putative NEF/HSP70 interaction site [polypeptide binding]; other site 575540006827 SBD interface [polypeptide binding]; other site 575540006828 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 575540006829 Predicted ATPase [General function prediction only]; Region: COG4637 575540006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540006831 Walker A/P-loop; other site 575540006832 ATP binding site [chemical binding]; other site 575540006833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540006834 Walker B; other site 575540006835 D-loop; other site 575540006836 H-loop/switch region; other site 575540006837 Protein of unknown function (DUF790); Region: DUF790; pfam05626 575540006838 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 575540006839 DEAD-like helicases superfamily; Region: DEXDc; smart00487 575540006840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540006841 ATP binding site [chemical binding]; other site 575540006842 putative Mg++ binding site [ion binding]; other site 575540006843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540006844 nucleotide binding region [chemical binding]; other site 575540006845 ATP-binding site [chemical binding]; other site 575540006846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540006847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540006848 active site 575540006849 ATP binding site [chemical binding]; other site 575540006850 substrate binding site [chemical binding]; other site 575540006851 activation loop (A-loop); other site 575540006852 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540006853 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540006854 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 575540006855 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 575540006856 Competence protein; Region: Competence; pfam03772 575540006857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 575540006858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540006859 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540006860 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 575540006861 Clp protease; Region: CLP_protease; pfam00574 575540006862 oligomer interface [polypeptide binding]; other site 575540006863 active site residues [active] 575540006864 trigger factor; Region: tig; TIGR00115 575540006865 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 575540006866 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 575540006867 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 575540006868 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 575540006869 active site 575540006870 catalytic site [active] 575540006871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540006872 catalytic core [active] 575540006873 cobalamin synthase; Reviewed; Region: cobS; PRK00235 575540006874 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 575540006875 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 575540006876 putative dimer interface [polypeptide binding]; other site 575540006877 active site pocket [active] 575540006878 putative cataytic base [active] 575540006879 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 575540006880 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 575540006881 Ligand Binding Site [chemical binding]; other site 575540006882 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 575540006883 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 575540006884 cobalamin binding residues [chemical binding]; other site 575540006885 putative BtuC binding residues; other site 575540006886 dimer interface [polypeptide binding]; other site 575540006887 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 575540006888 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 575540006889 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 575540006890 catalytic residues [active] 575540006891 catalytic nucleophile [active] 575540006892 Presynaptic Site I dimer interface [polypeptide binding]; other site 575540006893 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 575540006894 Synaptic Flat tetramer interface [polypeptide binding]; other site 575540006895 Synaptic Site I dimer interface [polypeptide binding]; other site 575540006896 DNA binding site [nucleotide binding] 575540006897 Recombinase; Region: Recombinase; pfam07508 575540006898 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 575540006899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 575540006900 Protein of unknown function (DUF433); Region: DUF433; pfam04255 575540006901 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 575540006902 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 575540006903 catalytic residues [active] 575540006904 catalytic nucleophile [active] 575540006905 Recombinase; Region: Recombinase; pfam07508 575540006906 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 575540006907 Recombinase; Region: Recombinase; pfam07508 575540006908 RHS Repeat; Region: RHS_repeat; pfam05593 575540006909 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 575540006910 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 575540006911 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 575540006912 protein-splicing catalytic site; other site 575540006913 thioester formation/cholesterol transfer; other site 575540006914 Pretoxin HINT domain; Region: PT-HINT; pfam07591 575540006915 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 575540006916 Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051 575540006917 Phage-related protein [Function unknown]; Region: COG5412 575540006918 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540006919 Phage major tail protein 2; Region: Phage_tail_2; cl11463 575540006920 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 575540006921 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 575540006922 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 575540006923 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 575540006924 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 575540006925 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 575540006926 AAA domain; Region: AAA_24; pfam13479 575540006927 Protein of unknown function (DUF669); Region: DUF669; pfam05037 575540006928 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 575540006929 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 575540006930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540006931 ATP binding site [chemical binding]; other site 575540006932 putative Mg++ binding site [ion binding]; other site 575540006933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540006934 nucleotide binding region [chemical binding]; other site 575540006935 ATP-binding site [chemical binding]; other site 575540006936 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 575540006937 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 575540006938 polymerase nucleotide-binding site; other site 575540006939 DNA-binding residues [nucleotide binding]; DNA binding site 575540006940 nucleotide binding site [chemical binding]; other site 575540006941 primase nucleotide-binding site [nucleotide binding]; other site 575540006942 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 575540006943 AAA domain; Region: AAA_25; pfam13481 575540006944 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 575540006945 ATP binding site [chemical binding]; other site 575540006946 Walker A motif; other site 575540006947 Walker B motif; other site 575540006948 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 575540006949 ParB-like nuclease domain; Region: ParB; smart00470 575540006950 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 575540006951 DNA methylase; Region: N6_N4_Mtase; pfam01555 575540006952 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 575540006953 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 575540006954 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 575540006955 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 575540006956 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 575540006957 catalytic residues [active] 575540006958 catalytic nucleophile [active] 575540006959 Presynaptic Site I dimer interface [polypeptide binding]; other site 575540006960 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 575540006961 Synaptic Flat tetramer interface [polypeptide binding]; other site 575540006962 Synaptic Site I dimer interface [polypeptide binding]; other site 575540006963 DNA binding site [nucleotide binding] 575540006964 Recombinase; Region: Recombinase; pfam07508 575540006965 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 575540006966 Right handed beta helix region; Region: Beta_helix; pfam13229 575540006967 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540006968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540006969 DNA binding residues [nucleotide binding] 575540006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540006971 Response regulator receiver domain; Region: Response_reg; pfam00072 575540006972 active site 575540006973 phosphorylation site [posttranslational modification] 575540006974 intermolecular recognition site; other site 575540006975 dimerization interface [polypeptide binding]; other site 575540006976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 575540006977 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 575540006978 Uncharacterized conserved protein [Function unknown]; Region: COG1543 575540006979 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 575540006980 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 575540006981 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 575540006982 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 575540006983 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 575540006984 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 575540006985 putative active site [active] 575540006986 dimerization interface [polypeptide binding]; other site 575540006987 putative tRNAtyr binding site [nucleotide binding]; other site 575540006988 glycerol kinase; Provisional; Region: glpK; PRK00047 575540006989 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 575540006990 N- and C-terminal domain interface [polypeptide binding]; other site 575540006991 active site 575540006992 MgATP binding site [chemical binding]; other site 575540006993 catalytic site [active] 575540006994 metal binding site [ion binding]; metal-binding site 575540006995 glycerol binding site [chemical binding]; other site 575540006996 homotetramer interface [polypeptide binding]; other site 575540006997 homodimer interface [polypeptide binding]; other site 575540006998 FBP binding site [chemical binding]; other site 575540006999 protein IIAGlc interface [polypeptide binding]; other site 575540007000 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540007001 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540007002 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 575540007003 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540007004 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540007005 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 575540007006 ApbE family; Region: ApbE; pfam02424 575540007007 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 575540007008 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 575540007009 homopentamer interface [polypeptide binding]; other site 575540007010 active site 575540007011 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 575540007012 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 575540007013 Ligand binding site; other site 575540007014 Putative Catalytic site; other site 575540007015 DXD motif; other site 575540007016 threonine synthase; Validated; Region: PRK06260 575540007017 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 575540007018 homodimer interface [polypeptide binding]; other site 575540007019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540007020 catalytic residue [active] 575540007021 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 575540007022 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540007023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540007024 active site 575540007025 phosphorylation site [posttranslational modification] 575540007026 intermolecular recognition site; other site 575540007027 dimerization interface [polypeptide binding]; other site 575540007028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540007029 Walker A motif; other site 575540007030 ATP binding site [chemical binding]; other site 575540007031 Walker B motif; other site 575540007032 arginine finger; other site 575540007033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540007034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 575540007035 dimer interface [polypeptide binding]; other site 575540007036 phosphorylation site [posttranslational modification] 575540007037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540007038 ATP binding site [chemical binding]; other site 575540007039 Mg2+ binding site [ion binding]; other site 575540007040 G-X-G motif; other site 575540007041 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007042 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 575540007043 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007044 putative active site [active] 575540007045 metal binding site [ion binding]; metal-binding site 575540007046 homodimer binding site [polypeptide binding]; other site 575540007047 phosphodiesterase; Provisional; Region: PRK12704 575540007048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540007049 Zn2+ binding site [ion binding]; other site 575540007050 Mg2+ binding site [ion binding]; other site 575540007051 potassium/proton antiporter; Reviewed; Region: PRK05326 575540007052 TrkA-C domain; Region: TrkA_C; pfam02080 575540007053 Transporter associated domain; Region: CorC_HlyC; smart01091 575540007054 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 575540007055 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 575540007056 active site 575540007057 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 575540007058 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 575540007059 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 575540007060 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 575540007061 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 575540007062 substrate binding site [chemical binding]; other site 575540007063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 575540007064 ATP binding site [chemical binding]; other site 575540007065 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 575540007066 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 575540007067 HIGH motif; other site 575540007068 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 575540007069 active site 575540007070 KMSKS motif; other site 575540007071 Trm112p-like protein; Region: Trm112p; cl01066 575540007072 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 575540007073 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540007074 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 575540007075 active site 575540007076 MarR family; Region: MarR_2; cl17246 575540007077 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 575540007078 Predicted flavoprotein [General function prediction only]; Region: COG0431 575540007079 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 575540007080 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540007081 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540007082 Catalytic site [active] 575540007083 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 575540007084 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 575540007085 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 575540007086 Putative methyltransferase; Region: Methyltransf_16; pfam10294 575540007087 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 575540007088 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 575540007089 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540007090 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540007091 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540007092 structural tetrad; other site 575540007093 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 575540007094 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 575540007095 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540007096 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540007097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540007098 PAS domain; Region: PAS_9; pfam13426 575540007099 putative active site [active] 575540007100 heme pocket [chemical binding]; other site 575540007101 PAS domain; Region: PAS_9; pfam13426 575540007102 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540007103 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540007104 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 575540007105 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 575540007106 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 575540007107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540007108 catalytic residue [active] 575540007109 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 575540007110 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540007111 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540007112 phosphopeptide binding site; other site 575540007113 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540007114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540007115 Walker A motif; other site 575540007116 ATP binding site [chemical binding]; other site 575540007117 Walker B motif; other site 575540007118 arginine finger; other site 575540007119 Tetratricopeptide repeat; Region: TPR_10; pfam13374 575540007120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007121 TPR motif; other site 575540007122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540007123 binding surface 575540007124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540007125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007126 binding surface 575540007127 TPR motif; other site 575540007128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540007129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540007130 Tetratricopeptide repeat; Region: TPR_10; pfam13374 575540007131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540007132 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 575540007133 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 575540007134 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540007135 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 575540007136 amphipathic channel; other site 575540007137 Asn-Pro-Ala signature motifs; other site 575540007138 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007139 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 575540007140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 575540007141 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 575540007142 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 575540007143 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 575540007144 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 575540007145 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 575540007146 dihydropteroate synthase-related protein; Region: TIGR00284 575540007147 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 575540007148 substrate binding pocket [chemical binding]; other site 575540007149 dimer interface [polypeptide binding]; other site 575540007150 inhibitor binding site; inhibition site 575540007151 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 575540007152 Protein of unknown function (DUF447); Region: DUF447; cl17801 575540007153 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007154 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 575540007155 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540007156 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540007157 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 575540007158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 575540007159 Zn2+ binding site [ion binding]; other site 575540007160 Mg2+ binding site [ion binding]; other site 575540007161 CHC2 zinc finger; Region: zf-CHC2; cl17510 575540007162 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 575540007163 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 575540007164 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 575540007165 TrkA-N domain; Region: TrkA_N; pfam02254 575540007166 TrkA-C domain; Region: TrkA_C; pfam02080 575540007167 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 575540007168 active site 575540007169 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540007170 Sulfatase; Region: Sulfatase; pfam00884 575540007171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540007172 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540007173 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 575540007174 active site 575540007175 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 575540007176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540007177 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 575540007178 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 575540007179 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 575540007180 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540007181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540007182 Uncharacterized conserved protein [Function unknown]; Region: COG4198 575540007183 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 575540007184 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 575540007185 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 575540007186 homotetramer interface [polypeptide binding]; other site 575540007187 ligand binding site [chemical binding]; other site 575540007188 catalytic site [active] 575540007189 NAD binding site [chemical binding]; other site 575540007190 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 575540007191 arsenical-resistance protein; Region: acr3; TIGR00832 575540007192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 575540007193 Low molecular weight phosphatase family; Region: LMWPc; cl00105 575540007194 active site 575540007195 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 575540007196 Predicted permease; Region: DUF318; cl17795 575540007197 Predicted permease; Region: DUF318; cl17795 575540007198 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 575540007199 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540007200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540007201 S-adenosylmethionine binding site [chemical binding]; other site 575540007202 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 575540007203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540007204 dimerization interface [polypeptide binding]; other site 575540007205 putative DNA binding site [nucleotide binding]; other site 575540007206 putative Zn2+ binding site [ion binding]; other site 575540007207 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 575540007208 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 575540007209 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 575540007210 active site 575540007211 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 575540007212 dephospho-CoA kinase; Region: TIGR00152 575540007213 CoA-binding site [chemical binding]; other site 575540007214 ATP-binding [chemical binding]; other site 575540007215 transcription termination factor Rho; Provisional; Region: rho; PRK09376 575540007216 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 575540007217 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 575540007218 RNA binding site [nucleotide binding]; other site 575540007219 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 575540007220 multimer interface [polypeptide binding]; other site 575540007221 Walker A motif; other site 575540007222 ATP binding site [chemical binding]; other site 575540007223 Walker B motif; other site 575540007224 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 575540007225 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 575540007226 folate binding site [chemical binding]; other site 575540007227 NADP+ binding site [chemical binding]; other site 575540007228 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 575540007229 mce related protein; Region: MCE; pfam02470 575540007230 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 575540007231 putative RNA binding site [nucleotide binding]; other site 575540007232 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 575540007233 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 575540007234 active site 575540007235 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 575540007236 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 575540007237 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 575540007238 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 575540007239 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540007240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540007241 active site 575540007242 phosphorylation site [posttranslational modification] 575540007243 intermolecular recognition site; other site 575540007244 dimerization interface [polypeptide binding]; other site 575540007245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540007246 Walker A motif; other site 575540007247 ATP binding site [chemical binding]; other site 575540007248 Walker B motif; other site 575540007249 arginine finger; other site 575540007250 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540007251 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 575540007252 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 575540007253 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 575540007254 active site 575540007255 ADP/pyrophosphate binding site [chemical binding]; other site 575540007256 dimerization interface [polypeptide binding]; other site 575540007257 allosteric effector site; other site 575540007258 fructose-1,6-bisphosphate binding site; other site 575540007259 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 575540007260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 575540007261 PYR/PP interface [polypeptide binding]; other site 575540007262 dimer interface [polypeptide binding]; other site 575540007263 TPP binding site [chemical binding]; other site 575540007264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 575540007265 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 575540007266 TPP-binding site [chemical binding]; other site 575540007267 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 575540007268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540007269 Walker A/P-loop; other site 575540007270 ATP binding site [chemical binding]; other site 575540007271 Q-loop/lid; other site 575540007272 ABC transporter signature motif; other site 575540007273 Walker B; other site 575540007274 D-loop; other site 575540007275 H-loop/switch region; other site 575540007276 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 575540007277 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 575540007278 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 575540007279 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 575540007280 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 575540007281 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 575540007282 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 575540007283 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 575540007284 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007285 active site 575540007286 metal binding site [ion binding]; metal-binding site 575540007287 homotetramer interface [polypeptide binding]; other site 575540007288 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540007289 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540007290 Yqey-like protein; Region: YqeY; cl17540 575540007291 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 575540007292 metal binding site 2 [ion binding]; metal-binding site 575540007293 putative DNA binding helix; other site 575540007294 metal binding site 1 [ion binding]; metal-binding site 575540007295 dimer interface [polypeptide binding]; other site 575540007296 structural Zn2+ binding site [ion binding]; other site 575540007297 fumarate hydratase; Reviewed; Region: fumC; PRK00485 575540007298 Class II fumarases; Region: Fumarase_classII; cd01362 575540007299 active site 575540007300 tetramer interface [polypeptide binding]; other site 575540007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540007302 S-adenosylmethionine binding site [chemical binding]; other site 575540007303 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 575540007304 Glycoprotease family; Region: Peptidase_M22; pfam00814 575540007305 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 575540007306 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007307 active site 575540007308 metal binding site [ion binding]; metal-binding site 575540007309 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 575540007310 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 575540007311 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 575540007312 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540007313 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 575540007314 intracellular protease, PfpI family; Region: PfpI; TIGR01382 575540007315 proposed catalytic triad [active] 575540007316 conserved cys residue [active] 575540007317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540007318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540007319 NAD(P) binding site [chemical binding]; other site 575540007320 active site 575540007321 transaldolase-like protein; Provisional; Region: PTZ00411 575540007322 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 575540007323 active site 575540007324 dimer interface [polypeptide binding]; other site 575540007325 catalytic residue [active] 575540007326 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 575540007327 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 575540007328 active site 575540007329 dimer interface [polypeptide binding]; other site 575540007330 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 575540007331 dimer interface [polypeptide binding]; other site 575540007332 active site 575540007333 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 575540007334 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 575540007335 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540007336 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540007337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540007338 C-terminal peptidase (prc); Region: prc; TIGR00225 575540007339 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 575540007340 protein binding site [polypeptide binding]; other site 575540007341 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 575540007342 Catalytic dyad [active] 575540007343 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 575540007344 C-terminal peptidase (prc); Region: prc; TIGR00225 575540007345 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 575540007346 protein binding site [polypeptide binding]; other site 575540007347 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 575540007348 Catalytic dyad [active] 575540007349 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 575540007350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540007351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 575540007352 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 575540007353 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540007354 G2 box; other site 575540007355 Switch I region; other site 575540007356 G3 box; other site 575540007357 Switch II region; other site 575540007358 GTP/Mg2+ binding site [chemical binding]; other site 575540007359 G4 box; other site 575540007360 G5 box; other site 575540007361 Ribosome receptor lysine/proline rich region; Region: Rib_recp_KP_reg; pfam05104 575540007362 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 575540007363 MoaE interaction surface [polypeptide binding]; other site 575540007364 MoeB interaction surface [polypeptide binding]; other site 575540007365 thiocarboxylated glycine; other site 575540007366 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 575540007367 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540007368 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326 575540007369 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 575540007370 dimer interface [polypeptide binding]; other site 575540007371 catalytic residue [active] 575540007372 metal binding site [ion binding]; metal-binding site 575540007373 Response regulator receiver domain; Region: Response_reg; pfam00072 575540007374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540007375 active site 575540007376 phosphorylation site [posttranslational modification] 575540007377 intermolecular recognition site; other site 575540007378 dimerization interface [polypeptide binding]; other site 575540007379 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 575540007380 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 575540007381 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 575540007382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540007383 ATP binding site [chemical binding]; other site 575540007384 Mg2+ binding site [ion binding]; other site 575540007385 G-X-G motif; other site 575540007386 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540007387 anti sigma factor interaction site; other site 575540007388 regulatory phosphorylation site [posttranslational modification]; other site 575540007389 ParB-like nuclease domain; Region: ParBc; cl02129 575540007390 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 575540007391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540007392 NAD(P) binding site [chemical binding]; other site 575540007393 active site 575540007394 Rrf2 family protein; Region: rrf2_super; TIGR00738 575540007395 Transcriptional regulator; Region: Rrf2; pfam02082 575540007396 acetyl-CoA synthetase; Provisional; Region: PRK00174 575540007397 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 575540007398 active site 575540007399 CoA binding site [chemical binding]; other site 575540007400 acyl-activating enzyme (AAE) consensus motif; other site 575540007401 AMP binding site [chemical binding]; other site 575540007402 acetate binding site [chemical binding]; other site 575540007403 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540007404 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540007405 catalytic residues [active] 575540007406 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 575540007407 active site 575540007408 catalytic residues [active] 575540007409 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 575540007410 active site 575540007411 Zn binding site [ion binding]; other site 575540007412 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 575540007413 active site 575540007414 Zn binding site [ion binding]; other site 575540007415 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 575540007416 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 575540007417 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 575540007418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007419 TPR repeat; Region: TPR_11; pfam13414 575540007420 binding surface 575540007421 TPR motif; other site 575540007422 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 575540007423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007424 binding surface 575540007425 TPR motif; other site 575540007426 Trehalose utilisation; Region: ThuA; pfam06283 575540007427 conserved cys residue [active] 575540007428 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 575540007429 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 575540007430 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 575540007431 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 575540007432 molybdopterin cofactor binding site; other site 575540007433 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007434 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 575540007435 putative active site [active] 575540007436 putative metal binding site [ion binding]; other site 575540007437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540007438 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 575540007439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 575540007440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 575540007441 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 575540007442 active site 575540007443 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 575540007444 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 575540007445 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 575540007446 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 575540007447 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 575540007448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 575540007449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540007450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540007451 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 575540007452 OPT oligopeptide transporter protein; Region: OPT; cl14607 575540007453 putative oligopeptide transporter, OPT family; Region: TIGR00733 575540007454 OPT oligopeptide transporter protein; Region: OPT; cl14607 575540007455 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 575540007456 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 575540007457 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 575540007458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 575540007459 2-isopropylmalate synthase; Validated; Region: PRK00915 575540007460 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 575540007461 active site 575540007462 catalytic residues [active] 575540007463 metal binding site [ion binding]; metal-binding site 575540007464 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 575540007465 NADH dehydrogenase subunit E; Validated; Region: PRK07539 575540007466 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 575540007467 putative dimer interface [polypeptide binding]; other site 575540007468 [2Fe-2S] cluster binding site [ion binding]; other site 575540007469 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 575540007470 SLBB domain; Region: SLBB; pfam10531 575540007471 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 575540007472 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 575540007473 dimer interface [polypeptide binding]; other site 575540007474 ADP-ribose binding site [chemical binding]; other site 575540007475 active site 575540007476 nudix motif; other site 575540007477 metal binding site [ion binding]; metal-binding site 575540007478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 575540007479 Ligand Binding Site [chemical binding]; other site 575540007480 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 575540007481 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 575540007482 homodimer interface [polypeptide binding]; other site 575540007483 substrate-cofactor binding pocket; other site 575540007484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540007485 catalytic residue [active] 575540007486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540007487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540007488 Walker A/P-loop; other site 575540007489 ATP binding site [chemical binding]; other site 575540007490 Q-loop/lid; other site 575540007491 ABC transporter signature motif; other site 575540007492 Walker B; other site 575540007493 D-loop; other site 575540007494 H-loop/switch region; other site 575540007495 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 575540007496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540007497 FtsX-like permease family; Region: FtsX; pfam02687 575540007498 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 575540007499 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 575540007500 dimer interface [polypeptide binding]; other site 575540007501 putative anticodon binding site; other site 575540007502 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540007503 motif 1; other site 575540007504 dimer interface [polypeptide binding]; other site 575540007505 active site 575540007506 motif 2; other site 575540007507 motif 3; other site 575540007508 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540007509 Cytochrome c; Region: Cytochrom_C; pfam00034 575540007510 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 575540007511 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 575540007512 putative catalytic site [active] 575540007513 putative metal binding site [ion binding]; other site 575540007514 putative phosphate binding site [ion binding]; other site 575540007515 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 575540007516 Calx-beta domain; Region: Calx-beta; pfam03160 575540007517 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 575540007518 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 575540007519 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 575540007520 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 575540007521 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 575540007522 lipoyl attachment site [posttranslational modification]; other site 575540007523 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 575540007524 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 575540007525 tetramer interface [polypeptide binding]; other site 575540007526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540007527 catalytic residue [active] 575540007528 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 575540007529 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 575540007530 proposed catalytic triad [active] 575540007531 active site nucleophile [active] 575540007532 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 575540007533 proposed catalytic triad [active] 575540007534 active site nucleophile [active] 575540007535 seryl-tRNA synthetase; Provisional; Region: PRK05431 575540007536 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 575540007537 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 575540007538 dimer interface [polypeptide binding]; other site 575540007539 active site 575540007540 motif 1; other site 575540007541 motif 2; other site 575540007542 motif 3; other site 575540007543 hypothetical protein; Provisional; Region: PRK08201 575540007544 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 575540007545 metal binding site [ion binding]; metal-binding site 575540007546 putative dimer interface [polypeptide binding]; other site 575540007547 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 575540007548 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 575540007549 ATP binding site [chemical binding]; other site 575540007550 substrate binding site [chemical binding]; other site 575540007551 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 575540007552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540007553 ATP binding site [chemical binding]; other site 575540007554 putative Mg++ binding site [ion binding]; other site 575540007555 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540007556 ATP-binding site [chemical binding]; other site 575540007557 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 575540007558 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 575540007559 active site 575540007560 (T/H)XGH motif; other site 575540007561 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 575540007562 DNA binding site [nucleotide binding] 575540007563 active site 575540007564 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 575540007565 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 575540007566 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 575540007567 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 575540007568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 575540007569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540007570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 575540007571 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 575540007572 active site residue [active] 575540007573 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 575540007574 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 575540007575 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 575540007576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540007577 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540007578 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540007579 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540007580 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540007581 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 575540007582 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 575540007583 active site 575540007584 HIGH motif; other site 575540007585 KMSKS motif; other site 575540007586 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 575540007587 tRNA binding surface [nucleotide binding]; other site 575540007588 anticodon binding site; other site 575540007589 Putative phosphatase (DUF442); Region: DUF442; cl17385 575540007590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540007591 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540007592 NAD(P) binding site [chemical binding]; other site 575540007593 active site 575540007594 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 575540007595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540007596 S-adenosylmethionine binding site [chemical binding]; other site 575540007597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540007598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540007599 active site 575540007600 ATP binding site [chemical binding]; other site 575540007601 substrate binding site [chemical binding]; other site 575540007602 activation loop (A-loop); other site 575540007603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007604 TPR motif; other site 575540007605 binding surface 575540007606 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 575540007607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007608 TPR motif; other site 575540007609 binding surface 575540007610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007611 binding surface 575540007612 TPR motif; other site 575540007613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007614 TPR motif; other site 575540007615 binding surface 575540007616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007617 TPR repeat; Region: TPR_11; pfam13414 575540007618 binding surface 575540007619 TPR motif; other site 575540007620 TPR repeat; Region: TPR_11; pfam13414 575540007621 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 575540007622 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 575540007623 ATP-dependent DNA ligase; Validated; Region: PRK09247 575540007624 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 575540007625 active site 575540007626 DNA binding site [nucleotide binding] 575540007627 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 575540007628 DNA binding site [nucleotide binding] 575540007629 Quinolinate synthetase A protein; Region: NadA; pfam02445 575540007630 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 575540007631 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 575540007632 putative active site [active] 575540007633 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 575540007634 nucleotide binding site/active site [active] 575540007635 HIT family signature motif; other site 575540007636 catalytic residue [active] 575540007637 elongation factor G; Reviewed; Region: PRK00007 575540007638 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 575540007639 G1 box; other site 575540007640 putative GEF interaction site [polypeptide binding]; other site 575540007641 GTP/Mg2+ binding site [chemical binding]; other site 575540007642 Switch I region; other site 575540007643 G2 box; other site 575540007644 G3 box; other site 575540007645 Switch II region; other site 575540007646 G4 box; other site 575540007647 G5 box; other site 575540007648 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 575540007649 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 575540007650 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 575540007651 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 575540007652 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 575540007653 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 575540007654 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540007655 Sulfatase; Region: Sulfatase; cl17466 575540007656 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 575540007657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 575540007658 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 575540007659 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540007660 metal ion-dependent adhesion site (MIDAS); other site 575540007661 SpoVR like protein; Region: SpoVR; pfam04293 575540007662 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 575540007663 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 575540007664 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 575540007665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540007666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540007667 Walker A/P-loop; other site 575540007668 ATP binding site [chemical binding]; other site 575540007669 Q-loop/lid; other site 575540007670 ABC transporter signature motif; other site 575540007671 Walker B; other site 575540007672 D-loop; other site 575540007673 H-loop/switch region; other site 575540007674 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 575540007675 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 575540007676 hypothetical protein; Provisional; Region: PRK14812 575540007677 substrate binding site [chemical binding]; other site 575540007678 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 575540007679 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 575540007680 substrate binding site [chemical binding]; other site 575540007681 ligand binding site [chemical binding]; other site 575540007682 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 575540007683 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 575540007684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 575540007685 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 575540007686 NHL repeat; Region: NHL; pfam01436 575540007687 NHL repeat; Region: NHL; pfam01436 575540007688 NHL repeat; Region: NHL; pfam01436 575540007689 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540007690 metal ion-dependent adhesion site (MIDAS); other site 575540007691 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 575540007692 von Willebrand factor type A domain; Region: VWA_2; pfam13519 575540007693 metal ion-dependent adhesion site (MIDAS); other site 575540007694 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 575540007695 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540007696 von Willebrand factor type A domain; Region: VWA_2; pfam13519 575540007697 metal ion-dependent adhesion site (MIDAS); other site 575540007698 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 575540007699 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540007700 metal ion-dependent adhesion site (MIDAS); other site 575540007701 multifunctional aminopeptidase A; Provisional; Region: PRK00913 575540007702 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 575540007703 interface (dimer of trimers) [polypeptide binding]; other site 575540007704 Substrate-binding/catalytic site; other site 575540007705 Zn-binding sites [ion binding]; other site 575540007706 Family description; Region: VCBS; pfam13517 575540007707 Family description; Region: VCBS; pfam13517 575540007708 Family description; Region: VCBS; pfam13517 575540007709 putative acyltransferase; Provisional; Region: PRK05790 575540007710 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 575540007711 dimer interface [polypeptide binding]; other site 575540007712 active site 575540007713 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 575540007714 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 575540007715 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 575540007716 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 575540007717 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 575540007718 putative active site [active] 575540007719 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 575540007720 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 575540007721 RNA binding surface [nucleotide binding]; other site 575540007722 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 575540007723 active site 575540007724 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 575540007725 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 575540007726 FAD binding pocket [chemical binding]; other site 575540007727 FAD binding motif [chemical binding]; other site 575540007728 phosphate binding motif [ion binding]; other site 575540007729 beta-alpha-beta structure motif; other site 575540007730 NAD binding pocket [chemical binding]; other site 575540007731 Iron coordination center [ion binding]; other site 575540007732 large tegument protein UL36; Provisional; Region: PHA03247 575540007733 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 575540007734 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 575540007735 putative hydrophobic ligand binding site [chemical binding]; other site 575540007736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540007737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540007738 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 575540007739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540007740 active site 575540007741 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 575540007742 PhoU domain; Region: PhoU; pfam01895 575540007743 PhoU domain; Region: PhoU; pfam01895 575540007744 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 575540007745 MG2 domain; Region: A2M_N; pfam01835 575540007746 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 575540007747 Alpha-2-macroglobulin family; Region: A2M; pfam00207 575540007748 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 575540007749 surface patch; other site 575540007750 thioester region; other site 575540007751 specificity defining residues; other site 575540007752 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 575540007753 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 575540007754 homotrimer interaction site [polypeptide binding]; other site 575540007755 putative active site [active] 575540007756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 575540007757 classical (c) SDRs; Region: SDR_c; cd05233 575540007758 NAD(P) binding site [chemical binding]; other site 575540007759 active site 575540007760 hypothetical protein; Provisional; Region: PRK02947 575540007761 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 575540007762 putative active site [active] 575540007763 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 575540007764 active site 575540007765 hydrophilic channel; other site 575540007766 dimerization interface [polypeptide binding]; other site 575540007767 catalytic residues [active] 575540007768 active site lid [active] 575540007769 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 575540007770 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 575540007771 HEAT repeats; Region: HEAT_2; pfam13646 575540007772 DNA-K related protein; Region: DUF3731; pfam12531 575540007773 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 575540007774 Cytochrome c; Region: Cytochrom_C; pfam00034 575540007775 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540007776 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 575540007777 FAD binding domain; Region: FAD_binding_4; pfam01565 575540007778 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 575540007779 Cysteine-rich domain; Region: CCG; pfam02754 575540007780 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540007781 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007782 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007783 Family description; Region: VCBS; pfam13517 575540007784 Family description; Region: VCBS; pfam13517 575540007785 Family description; Region: VCBS; pfam13517 575540007786 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 575540007787 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 575540007788 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 575540007789 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 575540007790 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 575540007791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540007792 nucleotide binding region [chemical binding]; other site 575540007793 ATP-binding site [chemical binding]; other site 575540007794 SEC-C motif; Region: SEC-C; pfam02810 575540007795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540007796 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540007797 active site 575540007798 ATP binding site [chemical binding]; other site 575540007799 substrate binding site [chemical binding]; other site 575540007800 activation loop (A-loop); other site 575540007801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007802 TPR motif; other site 575540007803 binding surface 575540007804 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540007805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 575540007806 DNA binding residues [nucleotide binding] 575540007807 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 575540007808 TrkA-N domain; Region: TrkA_N; pfam02254 575540007809 TrkA-C domain; Region: TrkA_C; pfam02080 575540007810 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 575540007811 TrkA-N domain; Region: TrkA_N; pfam02254 575540007812 excinuclease ABC subunit B; Provisional; Region: PRK05298 575540007813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540007814 ATP binding site [chemical binding]; other site 575540007815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540007816 nucleotide binding region [chemical binding]; other site 575540007817 ATP-binding site [chemical binding]; other site 575540007818 Ultra-violet resistance protein B; Region: UvrB; pfam12344 575540007819 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 575540007820 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 575540007821 dimerization interface [polypeptide binding]; other site 575540007822 active site 575540007823 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 575540007824 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 575540007825 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 575540007826 UbiA prenyltransferase family; Region: UbiA; pfam01040 575540007827 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 575540007828 HEAT repeats; Region: HEAT_2; pfam13646 575540007829 protein binding surface [polypeptide binding]; other site 575540007830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540007831 TPR motif; other site 575540007832 TPR repeat; Region: TPR_11; pfam13414 575540007833 binding surface 575540007834 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 575540007835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540007836 ATP binding site [chemical binding]; other site 575540007837 putative Mg++ binding site [ion binding]; other site 575540007838 nucleotide binding region [chemical binding]; other site 575540007839 helicase superfamily c-terminal domain; Region: HELICc; smart00490 575540007840 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 575540007841 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 575540007842 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 575540007843 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 575540007844 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 575540007845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540007846 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 575540007847 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 575540007848 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 575540007849 Interdomain contacts; other site 575540007850 Cytokine receptor motif; other site 575540007851 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540007852 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007853 active site 575540007854 metal binding site [ion binding]; metal-binding site 575540007855 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 575540007856 substrate binding site [chemical binding]; other site 575540007857 active site 575540007858 catalytic residues [active] 575540007859 heterodimer interface [polypeptide binding]; other site 575540007860 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 575540007861 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 575540007862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540007863 catalytic residue [active] 575540007864 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 575540007865 putative ligand binding pocket/active site [active] 575540007866 putative metal binding site [ion binding]; other site 575540007867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 575540007868 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 575540007869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 575540007870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540007871 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540007872 active site 575540007873 ATP binding site [chemical binding]; other site 575540007874 substrate binding site [chemical binding]; other site 575540007875 activation loop (A-loop); other site 575540007876 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 575540007877 TatD related DNase; Region: TatD_DNase; pfam01026 575540007878 active site 575540007879 large tegument protein UL36; Provisional; Region: PHA03247 575540007880 Uncharacterized conserved protein [Function unknown]; Region: COG5276 575540007881 LVIVD repeat; Region: LVIVD; pfam08309 575540007882 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540007883 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 575540007884 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 575540007885 GTP binding site; other site 575540007886 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 575540007887 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 575540007888 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540007889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540007890 PQQ-like domain; Region: PQQ_2; pfam13360 575540007891 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540007893 active site 575540007894 phosphorylation site [posttranslational modification] 575540007895 intermolecular recognition site; other site 575540007896 dimerization interface [polypeptide binding]; other site 575540007897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540007898 Walker A motif; other site 575540007899 ATP binding site [chemical binding]; other site 575540007900 Walker B motif; other site 575540007901 arginine finger; other site 575540007902 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540007903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 575540007904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 575540007905 dimerization interface [polypeptide binding]; other site 575540007906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540007907 dimer interface [polypeptide binding]; other site 575540007908 phosphorylation site [posttranslational modification] 575540007909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540007910 ATP binding site [chemical binding]; other site 575540007911 Mg2+ binding site [ion binding]; other site 575540007912 G-X-G motif; other site 575540007913 magnesium-transporting ATPase; Provisional; Region: PRK15122 575540007914 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 575540007915 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 575540007916 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 575540007917 Soluble P-type ATPase [General function prediction only]; Region: COG4087 575540007918 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 575540007919 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 575540007920 MgtC family; Region: MgtC; pfam02308 575540007921 pyruvate phosphate dikinase; Provisional; Region: PRK09279 575540007922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 575540007923 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 575540007924 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 575540007925 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 575540007926 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 575540007927 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 575540007928 Walker A motif; other site 575540007929 ATP binding site [chemical binding]; other site 575540007930 Walker B motif; other site 575540007931 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 575540007932 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 575540007933 Walker A motif; other site 575540007934 ATP binding site [chemical binding]; other site 575540007935 Walker B motif; other site 575540007936 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 575540007937 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 575540007938 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 575540007939 Walker A motif; other site 575540007940 ATP binding site [chemical binding]; other site 575540007941 Walker B motif; other site 575540007942 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 575540007943 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540007944 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 575540007945 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540007946 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540007947 Cytochrome c; Region: Cytochrom_C; pfam00034 575540007948 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 575540007949 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 575540007950 active site 575540007951 catalytic residues [active] 575540007952 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 575540007953 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 575540007954 isocitrate dehydrogenase; Validated; Region: PRK09222 575540007955 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 575540007956 heat shock protein 90; Provisional; Region: PRK05218 575540007957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540007958 ATP binding site [chemical binding]; other site 575540007959 Mg2+ binding site [ion binding]; other site 575540007960 G-X-G motif; other site 575540007961 Uncharacterized conserved protein [Function unknown]; Region: COG3342 575540007962 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 575540007963 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 575540007964 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 575540007965 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 575540007966 ring oligomerisation interface [polypeptide binding]; other site 575540007967 ATP/Mg binding site [chemical binding]; other site 575540007968 stacking interactions; other site 575540007969 hinge regions; other site 575540007970 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 575540007971 oligomerisation interface [polypeptide binding]; other site 575540007972 mobile loop; other site 575540007973 roof hairpin; other site 575540007974 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540007975 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540007976 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540007977 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 575540007978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540007979 putative active site [active] 575540007980 putative metal binding site [ion binding]; other site 575540007981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540007982 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 575540007983 ATP binding site [chemical binding]; other site 575540007984 putative Mg++ binding site [ion binding]; other site 575540007985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540007986 nucleotide binding region [chemical binding]; other site 575540007987 ATP-binding site [chemical binding]; other site 575540007988 DEAD/H associated; Region: DEAD_assoc; pfam08494 575540007989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540007990 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 575540007991 NAD(P) binding site [chemical binding]; other site 575540007992 active site 575540007993 Uncharacterized conserved protein [Function unknown]; Region: COG0327 575540007994 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 575540007995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 575540007996 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 575540007997 Uncharacterized conserved protein [Function unknown]; Region: COG0327 575540007998 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 575540007999 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 575540008000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540008001 catalytic residue [active] 575540008002 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 575540008003 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 575540008004 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 575540008005 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 575540008006 Rhomboid family; Region: Rhomboid; pfam01694 575540008007 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 575540008008 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 575540008009 dimerization interface [polypeptide binding]; other site 575540008010 active site 575540008011 metal binding site [ion binding]; metal-binding site 575540008012 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 575540008013 dsRNA binding site [nucleotide binding]; other site 575540008014 elongation factor P; Validated; Region: PRK00529 575540008015 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 575540008016 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 575540008017 RNA binding site [nucleotide binding]; other site 575540008018 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 575540008019 RNA binding site [nucleotide binding]; other site 575540008020 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 575540008021 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 575540008022 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 575540008023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540008024 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540008025 DNA binding residues [nucleotide binding] 575540008026 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 575540008027 minor groove reading motif; other site 575540008028 helix-hairpin-helix signature motif; other site 575540008029 active site 575540008030 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 575540008031 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540008032 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540008033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540008034 binding surface 575540008035 TPR motif; other site 575540008036 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008037 GMP synthase; Reviewed; Region: guaA; PRK00074 575540008038 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 575540008039 AMP/PPi binding site [chemical binding]; other site 575540008040 candidate oxyanion hole; other site 575540008041 catalytic triad [active] 575540008042 potential glutamine specificity residues [chemical binding]; other site 575540008043 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 575540008044 ATP Binding subdomain [chemical binding]; other site 575540008045 Dimerization subdomain; other site 575540008046 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 575540008047 Part of AAA domain; Region: AAA_19; pfam13245 575540008048 Family description; Region: UvrD_C_2; pfam13538 575540008049 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 575540008050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 575540008051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 575540008052 catalytic residue [active] 575540008053 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 575540008054 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 575540008055 dimer interface [polypeptide binding]; other site 575540008056 active site 575540008057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 575540008058 substrate binding site [chemical binding]; other site 575540008059 catalytic residue [active] 575540008060 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 575540008061 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 575540008062 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 575540008063 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 575540008064 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 575540008065 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 575540008066 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 575540008067 catalytic loop [active] 575540008068 iron binding site [ion binding]; other site 575540008069 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 575540008070 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540008071 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540008072 phosphopeptide binding site; other site 575540008073 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 575540008074 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 575540008075 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 575540008076 hypothetical protein; Provisional; Region: PRK13665 575540008077 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540008078 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540008079 protein binding site [polypeptide binding]; other site 575540008080 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540008081 protein binding site [polypeptide binding]; other site 575540008082 replicative DNA helicase; Region: DnaB; TIGR00665 575540008083 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 575540008084 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 575540008085 Walker A motif; other site 575540008086 ATP binding site [chemical binding]; other site 575540008087 Walker B motif; other site 575540008088 DNA binding loops [nucleotide binding] 575540008089 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 575540008090 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 575540008091 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 575540008092 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 575540008093 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 575540008094 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 575540008095 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 575540008096 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 575540008097 putative catalytic site [active] 575540008098 putative metal binding site [ion binding]; other site 575540008099 putative phosphate binding site [ion binding]; other site 575540008100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540008101 binding surface 575540008102 TPR motif; other site 575540008103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540008104 TPR motif; other site 575540008105 binding surface 575540008106 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 575540008107 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 575540008108 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540008109 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 575540008110 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 575540008111 tetramerization interface [polypeptide binding]; other site 575540008112 NAD(P) binding site [chemical binding]; other site 575540008113 catalytic residues [active] 575540008114 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 575540008115 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 575540008116 Protein of unknown function, DUF480; Region: DUF480; pfam04337 575540008117 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 575540008118 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 575540008119 dimer interface [polypeptide binding]; other site 575540008120 ssDNA binding site [nucleotide binding]; other site 575540008121 tetramer (dimer of dimers) interface [polypeptide binding]; other site 575540008122 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 575540008123 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 575540008124 putative active site [active] 575540008125 catalytic residue [active] 575540008126 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 575540008127 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 575540008128 5S rRNA interface [nucleotide binding]; other site 575540008129 CTC domain interface [polypeptide binding]; other site 575540008130 L16 interface [polypeptide binding]; other site 575540008131 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 575540008132 hydroxyglutarate oxidase; Provisional; Region: PRK11728 575540008133 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 575540008134 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 575540008135 Tetratricopeptide repeat; Region: TPR_6; pfam13174 575540008136 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540008137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540008138 catalytic residues [active] 575540008139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 575540008140 GAF domain; Region: GAF; pfam01590 575540008141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540008142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540008143 dimer interface [polypeptide binding]; other site 575540008144 phosphorylation site [posttranslational modification] 575540008145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008146 ATP binding site [chemical binding]; other site 575540008147 Mg2+ binding site [ion binding]; other site 575540008148 G-X-G motif; other site 575540008149 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 575540008150 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 575540008151 thiamine phosphate binding site [chemical binding]; other site 575540008152 active site 575540008153 pyrophosphate binding site [ion binding]; other site 575540008154 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 575540008155 catalytic residues [active] 575540008156 dimer interface [polypeptide binding]; other site 575540008157 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540008158 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540008159 H+ Antiporter protein; Region: 2A0121; TIGR00900 575540008160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 575540008161 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 575540008162 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 575540008163 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 575540008164 putative active site [active] 575540008165 Zn binding site [ion binding]; other site 575540008166 argininosuccinate synthase; Provisional; Region: PRK13820 575540008167 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 575540008168 Ligand Binding Site [chemical binding]; other site 575540008169 CSL zinc finger; Region: zf-CSL; cl02163 575540008170 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 575540008171 PAS fold; Region: PAS_4; pfam08448 575540008172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008173 putative active site [active] 575540008174 heme pocket [chemical binding]; other site 575540008175 PAS domain S-box; Region: sensory_box; TIGR00229 575540008176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008177 putative active site [active] 575540008178 heme pocket [chemical binding]; other site 575540008179 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 575540008180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008181 putative active site [active] 575540008182 heme pocket [chemical binding]; other site 575540008183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540008184 dimer interface [polypeptide binding]; other site 575540008185 phosphorylation site [posttranslational modification] 575540008186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008187 ATP binding site [chemical binding]; other site 575540008188 Mg2+ binding site [ion binding]; other site 575540008189 G-X-G motif; other site 575540008190 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540008191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008192 active site 575540008193 phosphorylation site [posttranslational modification] 575540008194 intermolecular recognition site; other site 575540008195 dimerization interface [polypeptide binding]; other site 575540008196 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540008197 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540008198 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540008199 structural tetrad; other site 575540008200 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540008201 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540008202 structural tetrad; other site 575540008203 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 575540008204 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 575540008205 inhibitor-cofactor binding pocket; inhibition site 575540008206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540008207 catalytic residue [active] 575540008208 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540008209 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540008210 structural tetrad; other site 575540008211 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540008212 structural tetrad; other site 575540008213 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540008214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540008215 structural tetrad; other site 575540008216 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540008217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008218 active site 575540008219 phosphorylation site [posttranslational modification] 575540008220 intermolecular recognition site; other site 575540008221 dimerization interface [polypeptide binding]; other site 575540008222 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008223 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 575540008224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540008225 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540008226 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 575540008227 Domain of unknown function DUF20; Region: UPF0118; pfam01594 575540008228 selenophosphate synthetase; Provisional; Region: PRK00943 575540008229 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 575540008230 dimerization interface [polypeptide binding]; other site 575540008231 putative ATP binding site [chemical binding]; other site 575540008232 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 575540008233 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 575540008234 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 575540008235 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 575540008236 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 575540008237 GatB domain; Region: GatB_Yqey; smart00845 575540008238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 575540008239 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 575540008240 active site 575540008241 DNA binding site [nucleotide binding] 575540008242 Int/Topo IB signature motif; other site 575540008243 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 575540008244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 575540008245 Transporter associated domain; Region: CorC_HlyC; smart01091 575540008246 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 575540008247 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 575540008248 active site residue [active] 575540008249 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 575540008250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 575540008251 Beta-Casp domain; Region: Beta-Casp; pfam10996 575540008252 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 575540008253 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 575540008254 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 575540008255 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 575540008256 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 575540008257 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 575540008258 Phytochrome region; Region: PHY; pfam00360 575540008259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540008260 dimer interface [polypeptide binding]; other site 575540008261 phosphorylation site [posttranslational modification] 575540008262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008263 ATP binding site [chemical binding]; other site 575540008264 Mg2+ binding site [ion binding]; other site 575540008265 G-X-G motif; other site 575540008266 Response regulator receiver domain; Region: Response_reg; pfam00072 575540008267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008268 active site 575540008269 phosphorylation site [posttranslational modification] 575540008270 intermolecular recognition site; other site 575540008271 dimerization interface [polypeptide binding]; other site 575540008272 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 575540008273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540008274 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540008275 Sulfatase; Region: Sulfatase; pfam00884 575540008276 Sulfatase; Region: Sulfatase; cl17466 575540008277 Peptidase family M48; Region: Peptidase_M48; cl12018 575540008278 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 575540008279 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 575540008280 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540008281 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540008282 protein binding site [polypeptide binding]; other site 575540008283 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540008284 protein binding site [polypeptide binding]; other site 575540008285 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 575540008286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540008287 FeS/SAM binding site; other site 575540008288 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540008289 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540008290 active site 575540008291 ATP binding site [chemical binding]; other site 575540008292 substrate binding site [chemical binding]; other site 575540008293 activation loop (A-loop); other site 575540008294 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540008295 TPR repeat; Region: TPR_11; pfam13414 575540008296 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 575540008297 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540008298 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540008299 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 575540008300 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 575540008301 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 575540008302 CAAX protease self-immunity; Region: Abi; pfam02517 575540008303 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 575540008304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540008305 Walker A/P-loop; other site 575540008306 ATP binding site [chemical binding]; other site 575540008307 Q-loop/lid; other site 575540008308 ABC transporter signature motif; other site 575540008309 Walker B; other site 575540008310 D-loop; other site 575540008311 H-loop/switch region; other site 575540008312 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 575540008313 anti sigma factor interaction site; other site 575540008314 regulatory phosphorylation site [posttranslational modification]; other site 575540008315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 575540008316 active site 575540008317 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 575540008318 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 575540008319 DNA binding residues [nucleotide binding] 575540008320 B12 binding domain; Region: B12-binding_2; pfam02607 575540008321 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 575540008322 B12 binding site [chemical binding]; other site 575540008323 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 575540008324 CARDB; Region: CARDB; pfam07705 575540008325 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 575540008326 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 575540008327 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 575540008328 putative ligand binding site [chemical binding]; other site 575540008329 putative NAD binding site [chemical binding]; other site 575540008330 catalytic site [active] 575540008331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540008332 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540008333 phosphopeptide binding site; other site 575540008334 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 575540008335 GAF domain; Region: GAF; pfam01590 575540008336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540008337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008338 ATP binding site [chemical binding]; other site 575540008339 Mg2+ binding site [ion binding]; other site 575540008340 G-X-G motif; other site 575540008341 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540008342 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 575540008343 Protein of unknown function (DUF429); Region: DUF429; cl12046 575540008344 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 575540008345 6-phosphofructokinase; Region: PLN02884 575540008346 active site 575540008347 ADP/pyrophosphate binding site [chemical binding]; other site 575540008348 allosteric effector site; other site 575540008349 dimerization interface [polypeptide binding]; other site 575540008350 fructose-1,6-bisphosphate binding site; other site 575540008351 TM2 domain; Region: TM2; cl00984 575540008352 RNA methyltransferase, RsmE family; Region: TIGR00046 575540008353 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 575540008354 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 575540008355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540008356 dimerization interface [polypeptide binding]; other site 575540008357 putative DNA binding site [nucleotide binding]; other site 575540008358 putative Zn2+ binding site [ion binding]; other site 575540008359 SPFH domain / Band 7 family; Region: Band_7; pfam01145 575540008360 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 575540008361 SPFH domain / Band 7 family; Region: Band_7; pfam01145 575540008362 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 575540008363 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 575540008364 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 575540008365 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 575540008366 nucleotide binding site [chemical binding]; other site 575540008367 PAS domain S-box; Region: sensory_box; TIGR00229 575540008368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008369 putative active site [active] 575540008370 heme pocket [chemical binding]; other site 575540008371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540008372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540008373 dimer interface [polypeptide binding]; other site 575540008374 phosphorylation site [posttranslational modification] 575540008375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008376 ATP binding site [chemical binding]; other site 575540008377 Mg2+ binding site [ion binding]; other site 575540008378 G-X-G motif; other site 575540008379 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540008380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008381 active site 575540008382 phosphorylation site [posttranslational modification] 575540008383 intermolecular recognition site; other site 575540008384 dimerization interface [polypeptide binding]; other site 575540008385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540008386 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 575540008387 Metal-binding active site; metal-binding site 575540008388 hypothetical protein; Provisional; Region: PRK07208 575540008389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 575540008390 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 575540008391 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 575540008392 classical (c) SDRs; Region: SDR_c; cd05233 575540008393 NAD(P) binding site [chemical binding]; other site 575540008394 active site 575540008395 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 575540008396 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 575540008397 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 575540008398 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540008399 G1 box; other site 575540008400 GTP/Mg2+ binding site [chemical binding]; other site 575540008401 G2 box; other site 575540008402 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540008403 G1 box; other site 575540008404 GTP/Mg2+ binding site [chemical binding]; other site 575540008405 G2 box; other site 575540008406 Switch I region; other site 575540008407 G3 box; other site 575540008408 Switch II region; other site 575540008409 G4 box; other site 575540008410 G5 box; other site 575540008411 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 575540008412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540008413 Walker A motif; other site 575540008414 ATP binding site [chemical binding]; other site 575540008415 Walker B motif; other site 575540008416 arginine finger; other site 575540008417 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 575540008418 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 575540008419 recombination protein RecR; Reviewed; Region: recR; PRK00076 575540008420 RecR protein; Region: RecR; pfam02132 575540008421 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 575540008422 putative active site [active] 575540008423 putative metal-binding site [ion binding]; other site 575540008424 tetramer interface [polypeptide binding]; other site 575540008425 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 575540008426 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 575540008427 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 575540008428 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 575540008429 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 575540008430 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 575540008431 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 575540008432 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 575540008433 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 575540008434 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 575540008435 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 575540008436 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 575540008437 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 575540008438 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 575540008439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 575540008440 active site 575540008441 DNA binding site [nucleotide binding] 575540008442 Int/Topo IB signature motif; other site 575540008443 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540008444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008445 active site 575540008446 phosphorylation site [posttranslational modification] 575540008447 dimerization interface [polypeptide binding]; other site 575540008448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540008449 Walker A motif; other site 575540008450 ATP binding site [chemical binding]; other site 575540008451 Walker B motif; other site 575540008452 arginine finger; other site 575540008453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540008454 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540008455 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 575540008456 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540008457 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540008458 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540008459 Protein phosphatase 2C; Region: PP2C; pfam00481 575540008460 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 575540008461 active site 575540008462 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 575540008463 MoaE homodimer interface [polypeptide binding]; other site 575540008464 MoaD interaction [polypeptide binding]; other site 575540008465 active site residues [active] 575540008466 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 575540008467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540008468 FeS/SAM binding site; other site 575540008469 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 575540008470 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 575540008471 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 575540008472 IHF dimer interface [polypeptide binding]; other site 575540008473 IHF - DNA interface [nucleotide binding]; other site 575540008474 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 575540008475 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 575540008476 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 575540008477 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 575540008478 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 575540008479 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 575540008480 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 575540008481 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 575540008482 dimer interface [polypeptide binding]; other site 575540008483 substrate binding site [chemical binding]; other site 575540008484 metal binding sites [ion binding]; metal-binding site 575540008485 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 575540008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540008487 NAD(P) binding site [chemical binding]; other site 575540008488 active site 575540008489 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540008490 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540008491 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 575540008492 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540008493 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540008494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540008495 Walker A/P-loop; other site 575540008496 ATP binding site [chemical binding]; other site 575540008497 Q-loop/lid; other site 575540008498 ABC transporter signature motif; other site 575540008499 Walker B; other site 575540008500 D-loop; other site 575540008501 H-loop/switch region; other site 575540008502 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540008503 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 575540008504 FtsX-like permease family; Region: FtsX; pfam02687 575540008505 PQQ-like domain; Region: PQQ_2; pfam13360 575540008506 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008507 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 575540008508 Oxygen tolerance; Region: BatD; pfam13584 575540008509 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 575540008510 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 575540008511 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 575540008512 metal binding site [ion binding]; metal-binding site 575540008513 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 575540008514 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 575540008515 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 575540008516 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 575540008517 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 575540008518 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008519 Survival protein SurE; Region: SurE; cl00448 575540008520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 575540008521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 575540008522 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 575540008523 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540008524 catalytic residues [active] 575540008525 Protein of unknown function (DUF502); Region: DUF502; cl01107 575540008526 DNA primase; Validated; Region: dnaG; PRK05667 575540008527 CHC2 zinc finger; Region: zf-CHC2; pfam01807 575540008528 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 575540008529 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 575540008530 active site 575540008531 metal binding site [ion binding]; metal-binding site 575540008532 interdomain interaction site; other site 575540008533 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 575540008534 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 575540008535 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 575540008536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540008537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 575540008538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540008539 DNA binding residues [nucleotide binding] 575540008540 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 575540008541 Putative zinc ribbon domain; Region: DUF164; pfam02591 575540008542 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 575540008543 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 575540008544 Mg++ binding site [ion binding]; other site 575540008545 putative catalytic motif [active] 575540008546 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 575540008547 Chain length determinant protein; Region: Wzz; pfam02706 575540008548 Chain length determinant protein; Region: Wzz; cl15801 575540008549 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 575540008550 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 575540008551 O-Antigen ligase; Region: Wzy_C; pfam04932 575540008552 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 575540008553 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 575540008554 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 575540008555 GDP-mannose 4,6-dehydratase; Region: PLN02653 575540008556 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 575540008557 NADP-binding site; other site 575540008558 homotetramer interface [polypeptide binding]; other site 575540008559 substrate binding site [chemical binding]; other site 575540008560 homodimer interface [polypeptide binding]; other site 575540008561 active site 575540008562 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 575540008563 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 575540008564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540008565 D-galactonate transporter; Region: 2A0114; TIGR00893 575540008566 putative substrate translocation pore; other site 575540008567 malate dehydrogenase; Provisional; Region: PRK05442 575540008568 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 575540008569 NAD(P) binding site [chemical binding]; other site 575540008570 LDH/MDH dimer interface [polypeptide binding]; other site 575540008571 substrate binding site [chemical binding]; other site 575540008572 DHH family; Region: DHH; pfam01368 575540008573 TspO/MBR family; Region: TspO_MBR; pfam03073 575540008574 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008575 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 575540008576 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 575540008577 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 575540008578 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 575540008579 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 575540008580 active site 575540008581 catalytic residues [active] 575540008582 metal binding site [ion binding]; metal-binding site 575540008583 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 575540008584 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 575540008585 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 575540008586 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 575540008587 putative active site [active] 575540008588 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 575540008589 Family description; Region: VCBS; pfam13517 575540008590 Family description; Region: VCBS; pfam13517 575540008591 Family description; Region: VCBS; pfam13517 575540008592 Family description; Region: VCBS; pfam13517 575540008593 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 575540008594 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540008595 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540008596 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540008597 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 575540008598 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 575540008599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540008600 catalytic core [active] 575540008601 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 575540008602 Amidinotransferase; Region: Amidinotransf; pfam02274 575540008603 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 575540008604 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 575540008605 active site 575540008606 PQQ-like domain; Region: PQQ_2; pfam13360 575540008607 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 575540008608 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 575540008609 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 575540008610 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 575540008611 putative dimer interface [polypeptide binding]; other site 575540008612 putative anticodon binding site; other site 575540008613 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 575540008614 homodimer interface [polypeptide binding]; other site 575540008615 motif 1; other site 575540008616 motif 2; other site 575540008617 active site 575540008618 motif 3; other site 575540008619 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 575540008620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540008621 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 575540008622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540008623 DNA binding residues [nucleotide binding] 575540008624 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 575540008625 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 575540008626 putative catalytic residue [active] 575540008627 CHAT domain; Region: CHAT; cl17868 575540008628 AAA ATPase domain; Region: AAA_16; pfam13191 575540008629 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540008630 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 575540008631 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540008632 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540008633 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540008634 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540008635 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540008636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540008637 active site 575540008638 ATP binding site [chemical binding]; other site 575540008639 substrate binding site [chemical binding]; other site 575540008640 activation loop (A-loop); other site 575540008641 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540008642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540008643 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 575540008644 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 575540008645 heterodimer interface [polypeptide binding]; other site 575540008646 active site 575540008647 FMN binding site [chemical binding]; other site 575540008648 homodimer interface [polypeptide binding]; other site 575540008649 substrate binding site [chemical binding]; other site 575540008650 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 575540008651 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 575540008652 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 575540008653 O-Antigen ligase; Region: Wzy_C; pfam04932 575540008654 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 575540008655 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 575540008656 Mg++ binding site [ion binding]; other site 575540008657 putative catalytic motif [active] 575540008658 substrate binding site [chemical binding]; other site 575540008659 prolyl-tRNA synthetase; Provisional; Region: PRK09194 575540008660 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 575540008661 dimer interface [polypeptide binding]; other site 575540008662 motif 1; other site 575540008663 active site 575540008664 motif 2; other site 575540008665 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 575540008666 putative deacylase active site [active] 575540008667 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540008668 active site 575540008669 motif 3; other site 575540008670 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 575540008671 anticodon binding site; other site 575540008672 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 575540008673 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 575540008674 Substrate binding site; other site 575540008675 Mg++ binding site; other site 575540008676 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 575540008677 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 575540008678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540008679 Coenzyme A binding pocket [chemical binding]; other site 575540008680 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 575540008681 [2Fe-2S] cluster binding site [ion binding]; other site 575540008682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 575540008683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 575540008684 active site 575540008685 catalytic tetrad [active] 575540008686 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 575540008687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 575540008688 minor groove reading motif; other site 575540008689 helix-hairpin-helix signature motif; other site 575540008690 substrate binding pocket [chemical binding]; other site 575540008691 active site 575540008692 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 575540008693 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 575540008694 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 575540008695 GTP cyclohydrolase I; Provisional; Region: PLN03044 575540008696 active site 575540008697 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 575540008698 FAD binding domain; Region: FAD_binding_4; pfam01565 575540008699 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 575540008700 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008701 ApbE family; Region: ApbE; pfam02424 575540008702 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 575540008703 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540008704 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540008705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540008706 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 575540008707 substrate binding site; other site 575540008708 dimer interface; other site 575540008709 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540008710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540008711 S-adenosylmethionine binding site [chemical binding]; other site 575540008712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540008713 S-adenosylmethionine binding site [chemical binding]; other site 575540008714 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 575540008715 Ligand binding site; other site 575540008716 Putative Catalytic site; other site 575540008717 DXD motif; other site 575540008718 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 575540008719 active site 575540008720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540008721 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540008722 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 575540008723 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 575540008724 active site 575540008725 homodimer interface [polypeptide binding]; other site 575540008726 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 575540008727 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 575540008728 Walker A/P-loop; other site 575540008729 ATP binding site [chemical binding]; other site 575540008730 Q-loop/lid; other site 575540008731 ABC transporter signature motif; other site 575540008732 Walker B; other site 575540008733 D-loop; other site 575540008734 H-loop/switch region; other site 575540008735 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 575540008736 putative carbohydrate binding site [chemical binding]; other site 575540008737 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 575540008738 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 575540008739 O-Antigen ligase; Region: Wzy_C; cl04850 575540008740 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 575540008741 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 575540008742 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 575540008743 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 575540008744 Nucleotide binding site [chemical binding]; other site 575540008745 DTAP/Switch II; other site 575540008746 Switch I; other site 575540008747 Calx-beta domain; Region: Calx-beta; cl02522 575540008748 Calx-beta domain; Region: Calx-beta; pfam03160 575540008749 Calx-beta domain; Region: Calx-beta; cl02522 575540008750 Calx-beta domain; Region: Calx-beta; pfam03160 575540008751 Calx-beta domain; Region: Calx-beta; cl02522 575540008752 Calx-beta domain; Region: Calx-beta; cl02522 575540008753 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 575540008754 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 575540008755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540008756 nucleotide binding region [chemical binding]; other site 575540008757 ATP-binding site [chemical binding]; other site 575540008758 Uncharacterized conserved protein [Function unknown]; Region: COG3391 575540008759 Restriction endonuclease; Region: Mrr_cat; pfam04471 575540008760 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 575540008761 HSP70 interaction site [polypeptide binding]; other site 575540008762 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 575540008763 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 575540008764 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 575540008765 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 575540008766 nucleotide binding site [chemical binding]; other site 575540008767 putative NEF/HSP70 interaction site [polypeptide binding]; other site 575540008768 SBD interface [polypeptide binding]; other site 575540008769 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540008770 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540008771 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 575540008772 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540008773 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 575540008774 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540008775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008776 intermolecular recognition site; other site 575540008777 active site 575540008778 dimerization interface [polypeptide binding]; other site 575540008779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 575540008780 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 575540008781 Mg2+ binding site [ion binding]; other site 575540008782 G-X-G motif; other site 575540008783 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 575540008784 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 575540008785 ATP-grasp domain; Region: ATP-grasp; pfam02222 575540008786 Penicillinase repressor; Region: Pencillinase_R; pfam03965 575540008787 glycogen branching enzyme; Provisional; Region: PRK05402 575540008788 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 575540008789 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 575540008790 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 575540008791 active site 575540008792 catalytic site [active] 575540008793 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 575540008794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540008795 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 575540008796 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 575540008797 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 575540008798 malonyl-CoA binding site [chemical binding]; other site 575540008799 dimer interface [polypeptide binding]; other site 575540008800 active site 575540008801 product binding site; other site 575540008802 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 575540008803 Microtubule-binding stalk of dynein motor; Region: MT; pfam12777 575540008804 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 575540008805 putative dimer interface [polypeptide binding]; other site 575540008806 [2Fe-2S] cluster binding site [ion binding]; other site 575540008807 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 575540008808 SLBB domain; Region: SLBB; pfam10531 575540008809 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 575540008810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 575540008811 catalytic loop [active] 575540008812 iron binding site [ion binding]; other site 575540008813 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 575540008814 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 575540008815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 575540008816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 575540008817 ligand binding site [chemical binding]; other site 575540008818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 575540008819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 575540008820 ligand binding site [chemical binding]; other site 575540008821 flexible hinge region; other site 575540008822 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 575540008823 4Fe-4S binding domain; Region: Fer4; pfam00037 575540008824 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 575540008825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 575540008826 active site 575540008827 dimer interface [polypeptide binding]; other site 575540008828 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 575540008829 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 575540008830 23S rRNA interface [nucleotide binding]; other site 575540008831 L3 interface [polypeptide binding]; other site 575540008832 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 575540008833 L-aspartate oxidase; Provisional; Region: PRK06175 575540008834 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 575540008835 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 575540008836 transcription termination factor Rho; Provisional; Region: PRK12678 575540008837 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 575540008838 Methyltransferase domain; Region: Methyltransf_31; pfam13847 575540008839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540008840 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 575540008841 putative catalytic site [active] 575540008842 putative metal binding site [ion binding]; other site 575540008843 putative phosphate binding site [ion binding]; other site 575540008844 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 575540008845 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540008846 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 575540008847 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 575540008848 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 575540008849 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 575540008850 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 575540008851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 575540008852 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 575540008853 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 575540008854 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 575540008855 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 575540008856 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 575540008857 RNA binding site [nucleotide binding]; other site 575540008858 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540008859 FtsX-like permease family; Region: FtsX; pfam02687 575540008860 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540008861 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540008862 Walker A/P-loop; other site 575540008863 ATP binding site [chemical binding]; other site 575540008864 Q-loop/lid; other site 575540008865 ABC transporter signature motif; other site 575540008866 Walker B; other site 575540008867 D-loop; other site 575540008868 H-loop/switch region; other site 575540008869 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 575540008870 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 575540008871 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540008872 Bax inhibitor 1 like; Region: BaxI_1; cl17691 575540008873 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 575540008874 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 575540008875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540008876 active site 575540008877 phosphorylation site [posttranslational modification] 575540008878 intermolecular recognition site; other site 575540008879 dimerization interface [polypeptide binding]; other site 575540008880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 575540008881 DNA binding residues [nucleotide binding] 575540008882 dimerization interface [polypeptide binding]; other site 575540008883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008884 PAS domain; Region: PAS_9; pfam13426 575540008885 putative active site [active] 575540008886 heme pocket [chemical binding]; other site 575540008887 PAS domain; Region: PAS; smart00091 575540008888 PAS fold; Region: PAS_4; pfam08448 575540008889 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540008890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008891 PAS domain; Region: PAS_9; pfam13426 575540008892 putative active site [active] 575540008893 heme pocket [chemical binding]; other site 575540008894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540008895 PAS fold; Region: PAS_3; pfam08447 575540008896 putative active site [active] 575540008897 heme pocket [chemical binding]; other site 575540008898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540008899 ATP binding site [chemical binding]; other site 575540008900 Mg2+ binding site [ion binding]; other site 575540008901 G-X-G motif; other site 575540008902 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 575540008903 active site 575540008904 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 575540008905 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 575540008906 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 575540008907 RIP metalloprotease RseP; Region: TIGR00054 575540008908 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 575540008909 putative substrate binding region [chemical binding]; other site 575540008910 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 575540008911 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 575540008912 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 575540008913 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 575540008914 Bacterial sugar transferase; Region: Bac_transf; pfam02397 575540008915 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 575540008916 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 575540008917 DXD motif; other site 575540008918 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 575540008919 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 575540008920 active site 575540008921 substrate binding site [chemical binding]; other site 575540008922 trimer interface [polypeptide binding]; other site 575540008923 CoA binding site [chemical binding]; other site 575540008924 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 575540008925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 575540008926 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540008927 metal ion-dependent adhesion site (MIDAS); other site 575540008928 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540008929 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 575540008930 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 575540008931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540008932 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 575540008933 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540008934 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 575540008935 putative catalytic site [active] 575540008936 putative metal binding site [ion binding]; other site 575540008937 putative phosphate binding site [ion binding]; other site 575540008938 Uncharacterized conserved protein [Function unknown]; Region: COG3379 575540008939 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 575540008940 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 575540008941 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 575540008942 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 575540008943 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 575540008944 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 575540008945 active site 575540008946 ADP/pyrophosphate binding site [chemical binding]; other site 575540008947 dimerization interface [polypeptide binding]; other site 575540008948 allosteric effector site; other site 575540008949 fructose-1,6-bisphosphate binding site; other site 575540008950 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 575540008951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 575540008952 motif II; other site 575540008953 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 575540008954 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540008955 PhoD-like phosphatase; Region: PhoD; pfam09423 575540008956 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 575540008957 putative active site [active] 575540008958 putative metal binding site [ion binding]; other site 575540008959 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 575540008960 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 575540008961 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 575540008962 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 575540008963 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 575540008964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540008965 FeS/SAM binding site; other site 575540008966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 575540008967 putative DNA binding site [nucleotide binding]; other site 575540008968 Predicted transcriptional regulator [Transcription]; Region: COG2345 575540008969 putative Zn2+ binding site [ion binding]; other site 575540008970 FeS assembly ATPase SufC; Region: sufC; TIGR01978 575540008971 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 575540008972 Walker A/P-loop; other site 575540008973 ATP binding site [chemical binding]; other site 575540008974 Q-loop/lid; other site 575540008975 ABC transporter signature motif; other site 575540008976 Walker B; other site 575540008977 D-loop; other site 575540008978 H-loop/switch region; other site 575540008979 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 575540008980 FeS assembly protein SufB; Region: sufB; TIGR01980 575540008981 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 575540008982 FeS assembly protein SufD; Region: sufD; TIGR01981 575540008983 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 575540008984 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 575540008985 active site residue [active] 575540008986 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 575540008987 active site residue [active] 575540008988 Fe-S metabolism associated domain; Region: SufE; cl00951 575540008989 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 575540008990 [2Fe-2S] cluster binding site [ion binding]; other site 575540008991 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 575540008992 6-phosphofructokinase; Provisional; Region: PRK03202 575540008993 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 575540008994 active site 575540008995 ADP/pyrophosphate binding site [chemical binding]; other site 575540008996 dimerization interface [polypeptide binding]; other site 575540008997 allosteric effector site; other site 575540008998 fructose-1,6-bisphosphate binding site; other site 575540008999 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009000 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 575540009001 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540009002 DNA interaction; other site 575540009003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 575540009004 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 575540009005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540009006 Walker A/P-loop; other site 575540009007 ATP binding site [chemical binding]; other site 575540009008 Q-loop/lid; other site 575540009009 ABC transporter signature motif; other site 575540009010 Walker B; other site 575540009011 D-loop; other site 575540009012 H-loop/switch region; other site 575540009013 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 575540009014 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540009015 Outer membrane efflux protein; Region: OEP; pfam02321 575540009016 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 575540009017 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 575540009018 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 575540009019 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 575540009020 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540009021 Walker A/P-loop; other site 575540009022 ATP binding site [chemical binding]; other site 575540009023 Q-loop/lid; other site 575540009024 ABC transporter signature motif; other site 575540009025 Walker B; other site 575540009026 D-loop; other site 575540009027 H-loop/switch region; other site 575540009028 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 575540009029 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 575540009030 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 575540009031 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 575540009032 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 575540009033 Tetratricopeptide repeat; Region: TPR_15; pfam13429 575540009034 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 575540009035 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009036 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009037 active site 575540009038 ATP binding site [chemical binding]; other site 575540009039 substrate binding site [chemical binding]; other site 575540009040 activation loop (A-loop); other site 575540009041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540009042 Tetratricopeptide repeat; Region: TPR_10; pfam13374 575540009043 CHAT domain; Region: CHAT; cl17868 575540009044 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009045 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009046 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009047 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009048 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009049 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009050 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 575540009051 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 575540009052 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 575540009053 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 575540009054 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 575540009055 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 575540009056 glycyl-tRNA synthetase; Provisional; Region: PRK04173 575540009057 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 575540009058 motif 1; other site 575540009059 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 575540009060 dimer interface [polypeptide binding]; other site 575540009061 active site 575540009062 motif 2; other site 575540009063 motif 3; other site 575540009064 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 575540009065 anticodon binding site; other site 575540009066 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 575540009067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009069 active site 575540009070 ATP binding site [chemical binding]; other site 575540009071 substrate binding site [chemical binding]; other site 575540009072 activation loop (A-loop); other site 575540009073 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540009074 Dynamin family; Region: Dynamin_N; pfam00350 575540009075 G1 box; other site 575540009076 GTP/Mg2+ binding site [chemical binding]; other site 575540009077 G2 box; other site 575540009078 Switch I region; other site 575540009079 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 575540009080 G3 box; other site 575540009081 Switch II region; other site 575540009082 G4 box; other site 575540009083 camphor resistance protein CrcB; Provisional; Region: PRK14195 575540009084 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 575540009085 Ligand binding site; other site 575540009086 Putative Catalytic site; other site 575540009087 DXD motif; other site 575540009088 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 575540009089 Maf-like protein; Region: Maf; pfam02545 575540009090 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 575540009091 active site 575540009092 dimer interface [polypeptide binding]; other site 575540009093 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 575540009094 Na binding site [ion binding]; other site 575540009095 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 575540009096 Beta-lactamase; Region: Beta-lactamase; pfam00144 575540009097 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 575540009098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540009099 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 575540009100 putative active site [active] 575540009101 heme pocket [chemical binding]; other site 575540009102 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 575540009103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 575540009104 putative active site [active] 575540009105 heme pocket [chemical binding]; other site 575540009106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540009107 dimer interface [polypeptide binding]; other site 575540009108 phosphorylation site [posttranslational modification] 575540009109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540009110 ATP binding site [chemical binding]; other site 575540009111 Mg2+ binding site [ion binding]; other site 575540009112 G-X-G motif; other site 575540009113 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540009114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540009115 active site 575540009116 phosphorylation site [posttranslational modification] 575540009117 intermolecular recognition site; other site 575540009118 dimerization interface [polypeptide binding]; other site 575540009119 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 575540009120 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 575540009121 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 575540009122 CAP-like domain; other site 575540009123 active site 575540009124 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 575540009125 primary dimer interface [polypeptide binding]; other site 575540009126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 575540009127 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 575540009128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540009129 ATP binding site [chemical binding]; other site 575540009130 Mg2+ binding site [ion binding]; other site 575540009131 G-X-G motif; other site 575540009132 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 575540009133 anchoring element; other site 575540009134 dimer interface [polypeptide binding]; other site 575540009135 ATP binding site [chemical binding]; other site 575540009136 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 575540009137 active site 575540009138 metal binding site [ion binding]; metal-binding site 575540009139 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 575540009140 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 575540009141 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 575540009142 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 575540009143 Fatty acid desaturase; Region: FA_desaturase; pfam00487 575540009144 Di-iron ligands [ion binding]; other site 575540009145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 575540009146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 575540009147 NAD(P) binding site [chemical binding]; other site 575540009148 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540009149 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540009150 NIPSNAP; Region: NIPSNAP; pfam07978 575540009151 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 575540009152 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540009153 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 575540009154 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 575540009155 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 575540009156 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 575540009157 protein binding site [polypeptide binding]; other site 575540009158 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 575540009159 Domain interface; other site 575540009160 Peptide binding site; other site 575540009161 Active site tetrad [active] 575540009162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540009163 dimer interface [polypeptide binding]; other site 575540009164 phosphorylation site [posttranslational modification] 575540009165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540009166 ATP binding site [chemical binding]; other site 575540009167 Mg2+ binding site [ion binding]; other site 575540009168 G-X-G motif; other site 575540009169 Response regulator receiver domain; Region: Response_reg; pfam00072 575540009170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540009171 active site 575540009172 phosphorylation site [posttranslational modification] 575540009173 intermolecular recognition site; other site 575540009174 dimerization interface [polypeptide binding]; other site 575540009175 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 575540009176 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 575540009177 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 575540009178 EamA-like transporter family; Region: EamA; pfam00892 575540009179 EamA-like transporter family; Region: EamA; pfam00892 575540009180 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 575540009181 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 575540009182 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; pfam01862 575540009183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 575540009184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540009185 ATP binding site [chemical binding]; other site 575540009186 putative Mg++ binding site [ion binding]; other site 575540009187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540009188 nucleotide binding region [chemical binding]; other site 575540009189 ATP-binding site [chemical binding]; other site 575540009190 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 575540009191 Duffy binding protein N terminal; Region: DuffyBP_N; pfam12377 575540009192 RQC domain; Region: RQC; pfam09382 575540009193 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 575540009194 DNA methylase; Region: N6_N4_Mtase; pfam01555 575540009195 DNA photolyase; Region: DNA_photolyase; pfam00875 575540009196 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 575540009197 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 575540009198 putative active site [active] 575540009199 Zn binding site [ion binding]; other site 575540009200 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 575540009201 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 575540009202 active site 575540009203 SAM binding site [chemical binding]; other site 575540009204 homodimer interface [polypeptide binding]; other site 575540009205 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 575540009206 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 575540009207 active site 575540009208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 575540009209 active site 575540009210 motif I; other site 575540009211 motif II; other site 575540009212 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 575540009213 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 575540009214 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 575540009215 TM-ABC transporter signature motif; other site 575540009216 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 575540009217 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 575540009218 Walker A/P-loop; other site 575540009219 ATP binding site [chemical binding]; other site 575540009220 Q-loop/lid; other site 575540009221 ABC transporter signature motif; other site 575540009222 Walker B; other site 575540009223 D-loop; other site 575540009224 H-loop/switch region; other site 575540009225 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 575540009226 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 575540009227 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 575540009228 ligand binding site [chemical binding]; other site 575540009229 dimerization interface [polypeptide binding]; other site 575540009230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540009231 S-adenosylmethionine binding site [chemical binding]; other site 575540009232 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 575540009233 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 575540009234 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 575540009235 active site 575540009236 catalytic nucleophile [active] 575540009237 dimer interface [polypeptide binding]; other site 575540009238 HEAT repeats; Region: HEAT_2; pfam13646 575540009239 HEAT repeat; Region: HEAT; pfam02985 575540009240 HEAT repeats; Region: HEAT_2; pfam13646 575540009241 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 575540009242 MutS domain III; Region: MutS_III; pfam05192 575540009243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540009244 Walker A/P-loop; other site 575540009245 ATP binding site [chemical binding]; other site 575540009246 Q-loop/lid; other site 575540009247 ABC transporter signature motif; other site 575540009248 Walker B; other site 575540009249 D-loop; other site 575540009250 H-loop/switch region; other site 575540009251 epoxyqueuosine reductase; Region: TIGR00276 575540009252 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 575540009253 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 575540009254 FAD binding site [chemical binding]; other site 575540009255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 575540009256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 575540009257 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009259 active site 575540009260 ATP binding site [chemical binding]; other site 575540009261 substrate binding site [chemical binding]; other site 575540009262 activation loop (A-loop); other site 575540009263 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540009264 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 575540009265 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540009266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540009267 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 575540009268 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 575540009269 dimerization interface [polypeptide binding]; other site 575540009270 putative ATP binding site [chemical binding]; other site 575540009271 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 575540009272 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 575540009273 ZIP Zinc transporter; Region: Zip; pfam02535 575540009274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 575540009275 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 575540009276 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 575540009277 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 575540009278 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 575540009279 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 575540009280 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 575540009281 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 575540009282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 575540009283 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 575540009284 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540009285 metal ion-dependent adhesion site (MIDAS); other site 575540009286 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540009287 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 575540009288 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 575540009289 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 575540009290 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540009291 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 575540009292 FtsX-like permease family; Region: FtsX; pfam02687 575540009293 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 575540009294 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 575540009295 FtsX-like permease family; Region: FtsX; pfam02687 575540009296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 575540009297 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 575540009298 Walker A/P-loop; other site 575540009299 ATP binding site [chemical binding]; other site 575540009300 Q-loop/lid; other site 575540009301 ABC transporter signature motif; other site 575540009302 Walker B; other site 575540009303 D-loop; other site 575540009304 H-loop/switch region; other site 575540009305 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540009306 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 575540009307 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540009308 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 575540009309 catalytic triad [active] 575540009310 putative active site [active] 575540009311 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009312 putative dehydratase; Provisional; Region: PRK08211 575540009313 Dehydratase family; Region: ILVD_EDD; cl00340 575540009314 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 575540009315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540009316 NAD(P) binding site [chemical binding]; other site 575540009317 active site 575540009318 Peptidase family M48; Region: Peptidase_M48; cl12018 575540009319 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 575540009320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 575540009321 ABC-ATPase subunit interface; other site 575540009322 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 575540009323 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 575540009324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540009325 Walker A/P-loop; other site 575540009326 ATP binding site [chemical binding]; other site 575540009327 Q-loop/lid; other site 575540009328 ABC transporter signature motif; other site 575540009329 Walker B; other site 575540009330 D-loop; other site 575540009331 H-loop/switch region; other site 575540009332 HEAT repeats; Region: HEAT_2; pfam13646 575540009333 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 575540009334 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 575540009335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540009336 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540009337 Right handed beta helix region; Region: Beta_helix; pfam13229 575540009338 Right handed beta helix region; Region: Beta_helix; pfam13229 575540009339 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 575540009340 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 575540009341 conserved cys residue [active] 575540009342 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009343 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009344 active site 575540009345 ATP binding site [chemical binding]; other site 575540009346 substrate binding site [chemical binding]; other site 575540009347 activation loop (A-loop); other site 575540009348 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 575540009349 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 575540009350 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 575540009351 catalytic site [active] 575540009352 subunit interface [polypeptide binding]; other site 575540009353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540009354 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540009355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009356 TPR motif; other site 575540009357 binding surface 575540009358 TPR repeat; Region: TPR_11; pfam13414 575540009359 TPR repeat; Region: TPR_11; pfam13414 575540009360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009361 binding surface 575540009362 TPR motif; other site 575540009363 Family description; Region: VCBS; pfam13517 575540009364 Family description; Region: VCBS; pfam13517 575540009365 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 575540009366 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 575540009367 nitrilase; Region: PLN02798 575540009368 active site 575540009369 catalytic triad [active] 575540009370 dimer interface [polypeptide binding]; other site 575540009371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540009372 TPR motif; other site 575540009373 binding surface 575540009374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540009375 binding surface 575540009376 TPR motif; other site 575540009377 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009379 active site 575540009380 ATP binding site [chemical binding]; other site 575540009381 substrate binding site [chemical binding]; other site 575540009382 activation loop (A-loop); other site 575540009383 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 575540009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540009385 NAD(P) binding site [chemical binding]; other site 575540009386 active site 575540009387 AAA-like domain; Region: AAA_10; pfam12846 575540009388 Domain of unknown function DUF87; Region: DUF87; pfam01935 575540009389 NurA nuclease; Region: NurA; smart00933 575540009390 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 575540009391 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 575540009392 Mrr N-terminal domain; Region: Mrr_N; pfam14338 575540009393 Restriction endonuclease; Region: Mrr_cat; pfam04471 575540009394 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 575540009395 Protein of unknown function (DUF499); Region: DUF499; pfam04465 575540009396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 575540009397 Protein of unknown function (DUF433); Region: DUF433; pfam04255 575540009398 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 575540009399 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 575540009400 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 575540009401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 575540009402 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 575540009403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540009404 ATP binding site [chemical binding]; other site 575540009405 putative Mg++ binding site [ion binding]; other site 575540009406 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 575540009407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540009408 nucleotide binding region [chemical binding]; other site 575540009409 ATP-binding site [chemical binding]; other site 575540009410 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 575540009411 DEAD-like helicases superfamily; Region: DEXDc; smart00487 575540009412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540009413 ATP binding site [chemical binding]; other site 575540009414 putative Mg++ binding site [ion binding]; other site 575540009415 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 575540009416 DNA methylase; Region: N6_N4_Mtase; pfam01555 575540009417 DNA methylase; Region: N6_N4_Mtase; cl17433 575540009418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 575540009419 ATP binding site [chemical binding]; other site 575540009420 putative Mg++ binding site [ion binding]; other site 575540009421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 575540009422 nucleotide binding region [chemical binding]; other site 575540009423 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 575540009424 ATP-binding site [chemical binding]; other site 575540009425 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 575540009426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540009427 Global regulator protein family; Region: CsrA; pfam02599 575540009428 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 575540009429 intracellular protease, PfpI family; Region: PfpI; TIGR01382 575540009430 conserved cys residue [active] 575540009431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 575540009432 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 575540009433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540009434 Walker A/P-loop; other site 575540009435 ATP binding site [chemical binding]; other site 575540009436 Q-loop/lid; other site 575540009437 ABC transporter signature motif; other site 575540009438 Walker B; other site 575540009439 D-loop; other site 575540009440 H-loop/switch region; other site 575540009441 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 575540009442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009444 active site 575540009445 ATP binding site [chemical binding]; other site 575540009446 substrate binding site [chemical binding]; other site 575540009447 activation loop (A-loop); other site 575540009448 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 575540009449 active site 575540009450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 575540009451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540009452 Coenzyme A binding pocket [chemical binding]; other site 575540009453 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540009454 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 575540009455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540009456 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 575540009457 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 575540009458 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 575540009459 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 575540009460 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009461 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009462 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 575540009463 FAD binding domain; Region: FAD_binding_4; pfam01565 575540009464 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 575540009465 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 575540009466 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 575540009467 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 575540009468 active site 575540009469 intersubunit interface [polypeptide binding]; other site 575540009470 catalytic residue [active] 575540009471 Uncharacterized conserved protein [Function unknown]; Region: COG2006 575540009472 Domain of unknown function (DUF362); Region: DUF362; pfam04015 575540009473 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540009474 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540009475 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 575540009476 active site 575540009477 catalytic residues [active] 575540009478 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 575540009479 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 575540009480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 575540009481 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 575540009482 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 575540009483 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 575540009484 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 575540009485 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 575540009486 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 575540009487 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 575540009488 benzoate transport; Region: 2A0115; TIGR00895 575540009489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540009490 putative substrate translocation pore; other site 575540009491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 575540009492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 575540009493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 575540009494 active site 575540009495 catalytic tetrad [active] 575540009496 Global regulator protein family; Region: CsrA; pfam02599 575540009497 Response regulator receiver domain; Region: Response_reg; pfam00072 575540009498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540009499 active site 575540009500 phosphorylation site [posttranslational modification] 575540009501 intermolecular recognition site; other site 575540009502 dimerization interface [polypeptide binding]; other site 575540009503 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 575540009504 Low molecular weight phosphatase family; Region: LMWPc; cd00115 575540009505 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 575540009506 active site 575540009507 Protein of unknown function (DUF493); Region: DUF493; pfam04359 575540009508 ribonuclease PH; Reviewed; Region: rph; PRK00173 575540009509 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 575540009510 oligomer interface [polypeptide binding]; other site 575540009511 RNA binding site [nucleotide binding]; other site 575540009512 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 575540009513 active site 575540009514 dimerization interface [polypeptide binding]; other site 575540009515 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 575540009516 Putative phosphatase (DUF442); Region: DUF442; cl17385 575540009517 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 575540009518 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 575540009519 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540009520 Walker A/P-loop; other site 575540009521 ATP binding site [chemical binding]; other site 575540009522 Q-loop/lid; other site 575540009523 ABC transporter signature motif; other site 575540009524 Walker B; other site 575540009525 D-loop; other site 575540009526 H-loop/switch region; other site 575540009527 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 575540009528 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 575540009529 glutamine binding [chemical binding]; other site 575540009530 catalytic triad [active] 575540009531 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 575540009532 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 575540009533 dimer interface [polypeptide binding]; other site 575540009534 putative functional site; other site 575540009535 putative MPT binding site; other site 575540009536 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 575540009537 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 575540009538 putative active site [active] 575540009539 catalytic triad [active] 575540009540 putative dimer interface [polypeptide binding]; other site 575540009541 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 575540009542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 575540009543 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 575540009544 DnaA box-binding interface [nucleotide binding]; other site 575540009545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 575540009546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540009547 active site 575540009548 metal binding site [ion binding]; metal-binding site 575540009549 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 575540009550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540009551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540009552 ABC transporter; Region: ABC_tran_2; pfam12848 575540009553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 575540009554 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 575540009555 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 575540009556 N- and C-terminal domain interface [polypeptide binding]; other site 575540009557 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 575540009558 active site 575540009559 putative catalytic site [active] 575540009560 metal binding site [ion binding]; metal-binding site 575540009561 ATP binding site [chemical binding]; other site 575540009562 carbohydrate binding site [chemical binding]; other site 575540009563 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 575540009564 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540009565 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009566 active site 575540009567 ATP binding site [chemical binding]; other site 575540009568 substrate binding site [chemical binding]; other site 575540009569 activation loop (A-loop); other site 575540009570 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540009571 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 575540009572 active site 575540009573 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540009574 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 575540009575 Ligand binding site; other site 575540009576 Putative Catalytic site; other site 575540009577 DXD motif; other site 575540009578 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 575540009579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540009580 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 575540009581 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 575540009582 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 575540009583 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009584 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 575540009585 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 575540009586 active site 575540009587 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 575540009588 Protein of unknown function, DUF393; Region: DUF393; pfam04134 575540009589 serine racemase; Region: PLN02970 575540009590 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 575540009591 tetramer interface [polypeptide binding]; other site 575540009592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540009593 catalytic residue [active] 575540009594 TPR repeat; Region: TPR_11; pfam13414 575540009595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009596 binding surface 575540009597 TPR motif; other site 575540009598 Protein kinase domain; Region: Pkinase; pfam00069 575540009599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540009600 active site 575540009601 ATP binding site [chemical binding]; other site 575540009602 substrate binding site [chemical binding]; other site 575540009603 activation loop (A-loop); other site 575540009604 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540009605 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 575540009606 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 575540009607 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 575540009608 active site 575540009609 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 575540009610 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 575540009611 ADP binding site [chemical binding]; other site 575540009612 phosphagen binding site; other site 575540009613 substrate specificity loop; other site 575540009614 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 575540009615 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 575540009616 UvrB/uvrC motif; Region: UVR; pfam02151 575540009617 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 575540009618 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 575540009619 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 575540009620 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 575540009621 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 575540009622 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 575540009623 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 575540009624 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 575540009625 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 575540009626 DNA binding site [nucleotide binding] 575540009627 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 575540009628 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 575540009629 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 575540009630 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 575540009631 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 575540009632 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 575540009633 G1 box; other site 575540009634 putative GEF interaction site [polypeptide binding]; other site 575540009635 GTP/Mg2+ binding site [chemical binding]; other site 575540009636 Switch I region; other site 575540009637 G2 box; other site 575540009638 G3 box; other site 575540009639 Switch II region; other site 575540009640 G4 box; other site 575540009641 G5 box; other site 575540009642 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 575540009643 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 575540009644 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 575540009645 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 575540009646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 575540009647 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 575540009648 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 575540009649 16S/18S rRNA binding site [nucleotide binding]; other site 575540009650 S13e-L30e interaction site [polypeptide binding]; other site 575540009651 25S rRNA binding site [nucleotide binding]; other site 575540009652 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 575540009653 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 575540009654 RNase E interface [polypeptide binding]; other site 575540009655 trimer interface [polypeptide binding]; other site 575540009656 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 575540009657 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 575540009658 RNase E interface [polypeptide binding]; other site 575540009659 trimer interface [polypeptide binding]; other site 575540009660 active site 575540009661 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 575540009662 putative nucleic acid binding region [nucleotide binding]; other site 575540009663 G-X-X-G motif; other site 575540009664 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 575540009665 RNA binding site [nucleotide binding]; other site 575540009666 domain interface; other site 575540009667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 575540009668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 575540009669 dimer interface [polypeptide binding]; other site 575540009670 phosphorylation site [posttranslational modification] 575540009671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540009672 ATP binding site [chemical binding]; other site 575540009673 G-X-G motif; other site 575540009674 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 575540009675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540009676 active site 575540009677 phosphorylation site [posttranslational modification] 575540009678 intermolecular recognition site; other site 575540009679 dimerization interface [polypeptide binding]; other site 575540009680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540009681 Walker A motif; other site 575540009682 ATP binding site [chemical binding]; other site 575540009683 Walker B motif; other site 575540009684 arginine finger; other site 575540009685 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 575540009686 DoxX-like family; Region: DoxX_2; pfam13564 575540009687 polyphosphate kinase; Provisional; Region: PRK05443 575540009688 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 575540009689 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 575540009690 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 575540009691 putative domain interface [polypeptide binding]; other site 575540009692 putative active site [active] 575540009693 catalytic site [active] 575540009694 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 575540009695 putative domain interface [polypeptide binding]; other site 575540009696 putative active site [active] 575540009697 catalytic site [active] 575540009698 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 575540009699 endonuclease IV; Provisional; Region: PRK01060 575540009700 AP (apurinic/apyrimidinic) site pocket; other site 575540009701 DNA interaction; other site 575540009702 Metal-binding active site; metal-binding site 575540009703 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 575540009704 heterotetramer interface [polypeptide binding]; other site 575540009705 active site pocket [active] 575540009706 cleavage site 575540009707 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 575540009708 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 575540009709 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 575540009710 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 575540009711 putative substrate binding site [chemical binding]; other site 575540009712 putative ATP binding site [chemical binding]; other site 575540009713 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 575540009714 AIR carboxylase; Region: AIRC; smart01001 575540009715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 575540009716 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 575540009717 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 575540009718 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 575540009719 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 575540009720 active site lid residues [active] 575540009721 substrate binding pocket [chemical binding]; other site 575540009722 catalytic residues [active] 575540009723 substrate-Mg2+ binding site; other site 575540009724 aspartate-rich region 1; other site 575540009725 aspartate-rich region 2; other site 575540009726 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 575540009727 active site lid residues [active] 575540009728 substrate binding pocket [chemical binding]; other site 575540009729 catalytic residues [active] 575540009730 substrate-Mg2+ binding site; other site 575540009731 aspartate-rich region 1; other site 575540009732 aspartate-rich region 2; other site 575540009733 Predicted membrane protein [Function unknown]; Region: COG4325 575540009734 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 575540009735 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 575540009736 lycopene cyclase; Region: lycopene_cycl; TIGR01789 575540009737 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 575540009738 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 575540009739 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 575540009740 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 575540009741 putative active site [active] 575540009742 catalytic site [active] 575540009743 putative metal binding site [ion binding]; other site 575540009744 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 575540009745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540009746 FeS/SAM binding site; other site 575540009747 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 575540009748 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 575540009749 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 575540009750 Probable Catalytic site; other site 575540009751 mercuric reductase; Validated; Region: PRK06370 575540009752 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 575540009753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 575540009754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 575540009755 Protein of unknown function DUF72; Region: DUF72; pfam01904 575540009756 Response regulator receiver domain; Region: Response_reg; pfam00072 575540009757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540009758 active site 575540009759 phosphorylation site [posttranslational modification] 575540009760 intermolecular recognition site; other site 575540009761 dimerization interface [polypeptide binding]; other site 575540009762 Hpt domain; Region: Hpt; pfam01627 575540009763 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 575540009764 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 575540009765 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 575540009766 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 575540009767 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 575540009768 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 575540009769 substrate binding site [chemical binding]; other site 575540009770 hexamer interface [polypeptide binding]; other site 575540009771 metal binding site [ion binding]; metal-binding site 575540009772 Phosphoglycerate kinase; Region: PGK; pfam00162 575540009773 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 575540009774 substrate binding site [chemical binding]; other site 575540009775 hinge regions; other site 575540009776 ADP binding site [chemical binding]; other site 575540009777 catalytic site [active] 575540009778 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 575540009779 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 575540009780 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 575540009781 hypothetical protein; Provisional; Region: PRK07877 575540009782 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 575540009783 dimer interface [polypeptide binding]; other site 575540009784 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 575540009785 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 575540009786 OsmC-like protein; Region: OsmC; pfam02566 575540009787 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540009788 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 575540009789 structural tetrad; other site 575540009790 FOG: WD40 repeat [General function prediction only]; Region: COG2319 575540009791 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 575540009792 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540009793 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540009794 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 575540009795 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 575540009796 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540009797 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 575540009798 RNA/DNA hybrid binding site [nucleotide binding]; other site 575540009799 active site 575540009800 flavoprotein, HI0933 family; Region: TIGR00275 575540009801 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 575540009802 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 575540009803 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 575540009804 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 575540009805 phosphate binding site [ion binding]; other site 575540009806 ATP-grasp domain; Region: ATP-grasp_4; cl17255 575540009807 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 575540009808 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 575540009809 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540009810 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540009811 metal ion-dependent adhesion site (MIDAS); other site 575540009812 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 575540009813 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 575540009814 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 575540009815 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 575540009816 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 575540009817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 575540009818 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540009819 metal ion-dependent adhesion site (MIDAS); other site 575540009820 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 575540009821 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 575540009822 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540009823 metal ion-dependent adhesion site (MIDAS); other site 575540009824 CARDB; Region: CARDB; pfam07705 575540009825 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 575540009826 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540009827 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540009828 metal ion-dependent adhesion site (MIDAS); other site 575540009829 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540009830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540009831 Walker A motif; other site 575540009832 ATP binding site [chemical binding]; other site 575540009833 Walker B motif; other site 575540009834 arginine finger; other site 575540009835 PQQ-like domain; Region: PQQ_2; pfam13360 575540009836 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 575540009837 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 575540009838 PQQ-like domain; Region: PQQ_2; pfam13360 575540009839 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 575540009840 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 575540009841 tRNA; other site 575540009842 putative tRNA binding site [nucleotide binding]; other site 575540009843 putative NADP binding site [chemical binding]; other site 575540009844 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 575540009845 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 575540009846 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 575540009847 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 575540009848 phosphopeptide binding site; other site 575540009849 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 575540009850 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 575540009851 metal binding site [ion binding]; metal-binding site 575540009852 active site 575540009853 I-site; other site 575540009854 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 575540009855 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540009856 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540009857 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 575540009858 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 575540009859 catalytic triad [active] 575540009860 LexA repressor; Validated; Region: PRK00215 575540009861 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 575540009862 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 575540009863 Catalytic site [active] 575540009864 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 575540009865 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 575540009866 aldehyde dehydrogenase family 7 member; Region: PLN02315 575540009867 tetrameric interface [polypeptide binding]; other site 575540009868 NAD binding site [chemical binding]; other site 575540009869 catalytic residues [active] 575540009870 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 575540009871 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 575540009872 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009873 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 575540009874 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 575540009875 putative catalytic cysteine [active] 575540009876 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 575540009877 dihydropteroate synthase; Region: DHPS; TIGR01496 575540009878 substrate binding pocket [chemical binding]; other site 575540009879 dimer interface [polypeptide binding]; other site 575540009880 inhibitor binding site; inhibition site 575540009881 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 575540009882 Tetratricopeptide repeat; Region: TPR_6; pfam13174 575540009883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009884 binding surface 575540009885 TPR motif; other site 575540009886 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 575540009887 Recombination protein O N terminal; Region: RecO_N; pfam11967 575540009888 Recombination protein O C terminal; Region: RecO_C; pfam02565 575540009889 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 575540009890 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 575540009891 DNA binding residues [nucleotide binding] 575540009892 B12 binding domain; Region: B12-binding_2; pfam02607 575540009893 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 575540009894 B12 binding site [chemical binding]; other site 575540009895 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 575540009896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 575540009897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 575540009898 DNA binding residues [nucleotide binding] 575540009899 MoxR-like ATPases [General function prediction only]; Region: COG0714 575540009900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 575540009901 Walker A motif; other site 575540009902 ATP binding site [chemical binding]; other site 575540009903 Walker B motif; other site 575540009904 arginine finger; other site 575540009905 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 575540009906 Protein of unknown function DUF58; Region: DUF58; pfam01882 575540009907 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 575540009908 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540009909 metal ion-dependent adhesion site (MIDAS); other site 575540009910 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 575540009911 metal ion-dependent adhesion site (MIDAS); other site 575540009912 EamA-like transporter family; Region: EamA; pfam00892 575540009913 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 575540009914 EamA-like transporter family; Region: EamA; pfam00892 575540009915 amino acid transporter; Region: 2A0306; TIGR00909 575540009916 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 575540009917 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 575540009918 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 575540009919 active site 575540009920 metal binding site [ion binding]; metal-binding site 575540009921 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 575540009922 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540009923 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 575540009924 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 575540009925 active site 575540009926 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 575540009927 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 575540009928 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 575540009929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540009930 Coenzyme A binding pocket [chemical binding]; other site 575540009931 Phosphotransferase enzyme family; Region: APH; pfam01636 575540009932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 575540009933 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 575540009934 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 575540009935 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 575540009936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009937 TPR motif; other site 575540009938 TPR repeat; Region: TPR_11; pfam13414 575540009939 binding surface 575540009940 Peptidase C26; Region: Peptidase_C26; pfam07722 575540009941 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 575540009942 catalytic triad [active] 575540009943 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 575540009944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 575540009945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 575540009946 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 575540009947 Walker A/P-loop; other site 575540009948 ATP binding site [chemical binding]; other site 575540009949 Q-loop/lid; other site 575540009950 ABC transporter signature motif; other site 575540009951 Walker B; other site 575540009952 D-loop; other site 575540009953 H-loop/switch region; other site 575540009954 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 575540009955 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 575540009956 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 575540009957 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 575540009958 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 575540009959 active site 575540009960 catalytic triad [active] 575540009961 oxyanion hole [active] 575540009962 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540009963 TPR repeat; Region: TPR_11; pfam13414 575540009964 Tetratricopeptide repeat; Region: TPR_1; pfam00515 575540009965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 575540009966 binding surface 575540009967 TPR motif; other site 575540009968 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540009969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009970 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540009971 binding surface 575540009972 TPR motif; other site 575540009973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540009974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540009975 binding surface 575540009976 TPR motif; other site 575540009977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540009978 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 575540009979 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 575540009980 tetramer interface [polypeptide binding]; other site 575540009981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540009982 catalytic residue [active] 575540009983 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 575540009984 histidinol dehydrogenase; Region: hisD; TIGR00069 575540009985 NAD binding site [chemical binding]; other site 575540009986 dimerization interface [polypeptide binding]; other site 575540009987 product binding site; other site 575540009988 substrate binding site [chemical binding]; other site 575540009989 zinc binding site [ion binding]; other site 575540009990 catalytic residues [active] 575540009991 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 575540009992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 575540009993 Coenzyme A binding pocket [chemical binding]; other site 575540009994 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 575540009995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 575540009996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540009997 homodimer interface [polypeptide binding]; other site 575540009998 catalytic residue [active] 575540009999 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 575540010000 putative active site pocket [active] 575540010001 4-fold oligomerization interface [polypeptide binding]; other site 575540010002 metal binding residues [ion binding]; metal-binding site 575540010003 3-fold/trimer interface [polypeptide binding]; other site 575540010004 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 575540010005 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 575540010006 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 575540010007 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 575540010008 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 575540010009 NAD binding site [chemical binding]; other site 575540010010 homodimer interface [polypeptide binding]; other site 575540010011 active site 575540010012 substrate binding site [chemical binding]; other site 575540010013 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 575540010014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 575540010015 NAD(P) binding site [chemical binding]; other site 575540010016 active site 575540010017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540010018 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540010019 GAF domain; Region: GAF; pfam01590 575540010020 GAF domain; Region: GAF_2; pfam13185 575540010021 Response regulator receiver domain; Region: Response_reg; pfam00072 575540010022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540010023 active site 575540010024 phosphorylation site [posttranslational modification] 575540010025 intermolecular recognition site; other site 575540010026 dimerization interface [polypeptide binding]; other site 575540010027 BNR repeat-like domain; Region: BNR_2; pfam13088 575540010028 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 575540010029 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 575540010030 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 575540010031 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 575540010032 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 575540010033 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 575540010034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 575540010035 Beta-lactamase; Region: Beta-lactamase; pfam00144 575540010036 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 575540010037 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 575540010038 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 575540010039 active site 575540010040 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 575540010041 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 575540010042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 575540010043 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540010044 active site 575540010045 ATP binding site [chemical binding]; other site 575540010046 substrate binding site [chemical binding]; other site 575540010047 activation loop (A-loop); other site 575540010048 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 575540010049 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 575540010050 putative homodimer interface [polypeptide binding]; other site 575540010051 active site 575540010052 SAM binding site [chemical binding]; other site 575540010053 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 575540010054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 575540010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540010056 S-adenosylmethionine binding site [chemical binding]; other site 575540010057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 575540010058 guanine deaminase; Provisional; Region: PRK09228 575540010059 active site 575540010060 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 575540010061 active site 575540010062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540010063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540010064 active site 575540010065 ATP binding site [chemical binding]; other site 575540010066 substrate binding site [chemical binding]; other site 575540010067 activation loop (A-loop); other site 575540010068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 575540010069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 575540010070 active site 575540010071 ATP binding site [chemical binding]; other site 575540010072 substrate binding site [chemical binding]; other site 575540010073 activation loop (A-loop); other site 575540010074 Uncharacterized conserved protein [Function unknown]; Region: COG1262 575540010075 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 575540010076 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 575540010077 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540010078 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 575540010079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540010080 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 575540010081 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 575540010082 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 575540010083 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 575540010084 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 575540010085 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 575540010086 4Fe-4S binding domain; Region: Fer4; pfam00037 575540010087 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 575540010088 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 575540010089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 575540010090 catalytic loop [active] 575540010091 iron binding site [ion binding]; other site 575540010092 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 575540010093 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 575540010094 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 575540010095 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 575540010096 SLBB domain; Region: SLBB; pfam10531 575540010097 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 575540010098 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 575540010099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 575540010100 catalytic residue [active] 575540010101 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 575540010102 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 575540010103 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 575540010104 catalytic Zn binding site [ion binding]; other site 575540010105 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 575540010106 structural Zn binding site [ion binding]; other site 575540010107 tetramer interface [polypeptide binding]; other site 575540010108 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 575540010109 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540010110 Domain of unknown function DUF11; Region: DUF11; cl17728 575540010111 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 575540010112 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 575540010113 active site 575540010114 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 575540010115 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 575540010116 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 575540010117 putative ligand binding site [chemical binding]; other site 575540010118 putative NAD binding site [chemical binding]; other site 575540010119 catalytic site [active] 575540010120 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540010121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540010122 Helix-turn-helix domain; Region: HTH_36; pfam13730 575540010123 ParB-like nuclease domain; Region: ParB; smart00470 575540010124 DNA methylase; Region: N6_N4_Mtase; cl17433 575540010125 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 575540010126 Methyltransferase domain; Region: Methyltransf_26; pfam13659 575540010127 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 575540010128 active site 575540010129 ribulose/triose binding site [chemical binding]; other site 575540010130 phosphate binding site [ion binding]; other site 575540010131 substrate (anthranilate) binding pocket [chemical binding]; other site 575540010132 product (indole) binding pocket [chemical binding]; other site 575540010133 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 575540010134 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 575540010135 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 575540010136 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 575540010137 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 575540010138 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 575540010139 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 575540010140 protein binding site [polypeptide binding]; other site 575540010141 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 575540010142 TPR repeat; Region: TPR_11; pfam13414 575540010143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540010144 binding surface 575540010145 TPR motif; other site 575540010146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540010147 binding surface 575540010148 TPR motif; other site 575540010149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540010150 TPR motif; other site 575540010151 binding surface 575540010152 Tetratricopeptide repeat; Region: TPR_16; pfam13432 575540010153 Response regulator receiver domain; Region: Response_reg; pfam00072 575540010154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540010155 active site 575540010156 phosphorylation site [posttranslational modification] 575540010157 intermolecular recognition site; other site 575540010158 dimerization interface [polypeptide binding]; other site 575540010159 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 575540010160 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540010161 Sulfatase; Region: Sulfatase; pfam00884 575540010162 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 575540010163 Sulfatase; Region: Sulfatase; pfam00884 575540010164 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 575540010165 homotrimer interaction site [polypeptide binding]; other site 575540010166 zinc binding site [ion binding]; other site 575540010167 CDP-binding sites; other site 575540010168 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 575540010169 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 575540010170 active site 575540010171 HIGH motif; other site 575540010172 nucleotide binding site [chemical binding]; other site 575540010173 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 575540010174 KMSKS motif; other site 575540010175 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 575540010176 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 575540010177 active site 575540010178 putative DNA-binding cleft [nucleotide binding]; other site 575540010179 dimer interface [polypeptide binding]; other site 575540010180 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 575540010181 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 575540010182 thiS-thiF/thiG interaction site; other site 575540010183 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 575540010184 ThiS interaction site; other site 575540010185 putative active site [active] 575540010186 tetramer interface [polypeptide binding]; other site 575540010187 Response regulator receiver domain; Region: Response_reg; pfam00072 575540010188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540010189 active site 575540010190 phosphorylation site [posttranslational modification] 575540010191 intermolecular recognition site; other site 575540010192 dimerization interface [polypeptide binding]; other site 575540010193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 575540010194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 575540010195 binding surface 575540010196 TPR motif; other site 575540010197 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 575540010198 putative CheA interaction surface; other site 575540010199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 575540010200 dimerization interface [polypeptide binding]; other site 575540010201 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 575540010202 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 575540010203 dimer interface [polypeptide binding]; other site 575540010204 putative CheW interface [polypeptide binding]; other site 575540010205 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540010206 putative binding surface; other site 575540010207 active site 575540010208 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540010209 putative binding surface; other site 575540010210 active site 575540010211 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540010212 putative binding surface; other site 575540010213 active site 575540010214 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 575540010215 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 575540010216 putative binding surface; other site 575540010217 active site 575540010218 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 575540010219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 575540010220 ATP binding site [chemical binding]; other site 575540010221 Mg2+ binding site [ion binding]; other site 575540010222 G-X-G motif; other site 575540010223 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 575540010224 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540010225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540010226 active site 575540010227 phosphorylation site [posttranslational modification] 575540010228 intermolecular recognition site; other site 575540010229 dimerization interface [polypeptide binding]; other site 575540010230 CheW-like domain; Region: CheW; pfam01584 575540010231 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 575540010232 putative ADP-binding pocket [chemical binding]; other site 575540010233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 575540010234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 575540010235 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 575540010236 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 575540010237 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 575540010238 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 575540010239 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 575540010240 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 575540010241 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 575540010242 Walker A/P-loop; other site 575540010243 ATP binding site [chemical binding]; other site 575540010244 Q-loop/lid; other site 575540010245 ABC transporter signature motif; other site 575540010246 Walker B; other site 575540010247 D-loop; other site 575540010248 H-loop/switch region; other site 575540010249 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 575540010250 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 575540010251 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 575540010252 Sulfate transporter family; Region: Sulfate_transp; pfam00916 575540010253 Uncharacterized conserved protein [Function unknown]; Region: COG0432 575540010254 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 575540010255 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 575540010256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 575540010257 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 575540010258 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 575540010259 Ligand binding site; other site 575540010260 Putative Catalytic site; other site 575540010261 DXD motif; other site 575540010262 Methyltransferase domain; Region: Methyltransf_23; pfam13489 575540010263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 575540010264 S-adenosylmethionine binding site [chemical binding]; other site 575540010265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 575540010266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 575540010267 DNA-binding site [nucleotide binding]; DNA binding site 575540010268 RNA-binding motif; other site 575540010269 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 575540010270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 575540010271 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 575540010272 active site 575540010273 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 575540010274 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 575540010275 Kelch motif; Region: Kelch_6; pfam13964 575540010276 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 575540010277 Kelch domain; Region: Kelch; smart00612 575540010278 Galactose oxidase, central domain; Region: Kelch_3; cl02701 575540010279 Kelch motif; Region: Kelch_1; pfam01344 575540010280 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 575540010281 Peptidase family M50; Region: Peptidase_M50; pfam02163 575540010282 active site 575540010283 putative substrate binding region [chemical binding]; other site 575540010284 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 575540010285 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 575540010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 575540010287 active site 575540010288 phosphorylation site [posttranslational modification] 575540010289 intermolecular recognition site; other site 575540010290 dimerization interface [polypeptide binding]; other site 575540010291 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 575540010292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 575540010293 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 575540010294 active site 575540010295 catalytic tetrad [active] 575540010296 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 575540010297 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 575540010298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 575540010299 FeS/SAM binding site; other site 575540010300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 575540010301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 575540010302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 575540010303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 575540010304 HlyD family secretion protein; Region: HlyD_3; pfam13437 575540010305 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 575540010306 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 575540010307 Isochorismatase family; Region: Isochorismatase; pfam00857 575540010308 catalytic triad [active] 575540010309 conserved cis-peptide bond; other site 575540010310 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 575540010311 homodimer interface [polypeptide binding]; other site 575540010312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 575540010313 catalytic residue [active] 575540010314 TPR repeat; Region: TPR_11; pfam13414 575540010315 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 575540010316 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 575540010317 SpoVG; Region: SpoVG; pfam04026 575540010318 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 575540010319 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 575540010320 domain interfaces; other site 575540010321 active site