-- dump date 20140619_120355 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471856000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 471856000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856000003 Walker A motif; other site 471856000004 ATP binding site [chemical binding]; other site 471856000005 Walker B motif; other site 471856000006 arginine finger; other site 471856000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471856000008 DnaA box-binding interface [nucleotide binding]; other site 471856000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 471856000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471856000011 putative DNA binding surface [nucleotide binding]; other site 471856000012 dimer interface [polypeptide binding]; other site 471856000013 beta-clamp/clamp loader binding surface; other site 471856000014 beta-clamp/translesion DNA polymerase binding surface; other site 471856000015 recombination protein F; Reviewed; Region: recF; PRK00064 471856000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 471856000017 Walker A/P-loop; other site 471856000018 ATP binding site [chemical binding]; other site 471856000019 Q-loop/lid; other site 471856000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000021 ABC transporter signature motif; other site 471856000022 Walker B; other site 471856000023 D-loop; other site 471856000024 H-loop/switch region; other site 471856000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 471856000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471856000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856000028 ATP binding site [chemical binding]; other site 471856000029 Mg2+ binding site [ion binding]; other site 471856000030 G-X-G motif; other site 471856000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471856000032 anchoring element; other site 471856000033 dimer interface [polypeptide binding]; other site 471856000034 ATP binding site [chemical binding]; other site 471856000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471856000036 active site 471856000037 putative metal-binding site [ion binding]; other site 471856000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471856000039 DNA gyrase subunit A; Validated; Region: PRK05560 471856000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471856000041 CAP-like domain; other site 471856000042 active site 471856000043 primary dimer interface [polypeptide binding]; other site 471856000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471856000050 AAA domain; Region: AAA_22; pfam13401 471856000051 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 471856000052 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471856000053 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471856000054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856000055 Walker A/P-loop; other site 471856000056 ATP binding site [chemical binding]; other site 471856000057 Q-loop/lid; other site 471856000058 ABC transporter signature motif; other site 471856000059 Walker B; other site 471856000060 D-loop; other site 471856000061 H-loop/switch region; other site 471856000062 RmuC family; Region: RmuC; pfam02646 471856000063 PQQ-like domain; Region: PQQ_2; pfam13360 471856000064 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471856000065 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471856000066 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471856000067 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 471856000068 BCCT family transporter; Region: BCCT; pfam02028 471856000069 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471856000070 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 471856000071 metal binding site [ion binding]; metal-binding site 471856000072 putative dimer interface [polypeptide binding]; other site 471856000073 pyruvate dehydrogenase; Provisional; Region: PRK09124 471856000074 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471856000075 PYR/PP interface [polypeptide binding]; other site 471856000076 dimer interface [polypeptide binding]; other site 471856000077 tetramer interface [polypeptide binding]; other site 471856000078 TPP binding site [chemical binding]; other site 471856000079 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471856000080 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 471856000081 TPP-binding site [chemical binding]; other site 471856000082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856000083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856000084 Protein export membrane protein; Region: SecD_SecF; cl14618 471856000085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471856000086 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471856000087 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471856000088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471856000089 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 471856000090 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471856000091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471856000092 active site 471856000093 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471856000094 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 471856000095 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471856000096 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471856000097 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471856000098 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471856000099 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 471856000100 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471856000101 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471856000102 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471856000103 active site 471856000104 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471856000105 Chain length determinant protein; Region: Wzz; cl15801 471856000106 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471856000107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471856000108 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471856000109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000110 Walker A/P-loop; other site 471856000111 ATP binding site [chemical binding]; other site 471856000112 Q-loop/lid; other site 471856000113 ABC transporter signature motif; other site 471856000114 Walker B; other site 471856000115 D-loop; other site 471856000116 H-loop/switch region; other site 471856000117 Fic family protein [Function unknown]; Region: COG3177 471856000118 Fic/DOC family; Region: Fic; pfam02661 471856000119 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 471856000120 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 471856000121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856000122 FeS/SAM binding site; other site 471856000123 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471856000124 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471856000125 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471856000126 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471856000127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000128 putative substrate translocation pore; other site 471856000129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856000130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856000131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471856000132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471856000133 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471856000134 putative dimerization interface [polypeptide binding]; other site 471856000135 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 471856000136 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 471856000137 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 471856000138 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 471856000139 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471856000140 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471856000141 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471856000142 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471856000143 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471856000144 putative substrate binding site [chemical binding]; other site 471856000145 putative ATP binding site [chemical binding]; other site 471856000146 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471856000147 active site 471856000148 phosphorylation site [posttranslational modification] 471856000149 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 471856000150 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471856000151 active site 471856000152 P-loop; other site 471856000153 phosphorylation site [posttranslational modification] 471856000154 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 471856000155 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471856000156 dimerization domain swap beta strand [polypeptide binding]; other site 471856000157 regulatory protein interface [polypeptide binding]; other site 471856000158 active site 471856000159 regulatory phosphorylation site [posttranslational modification]; other site 471856000160 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471856000161 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471856000162 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471856000163 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 471856000164 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 471856000165 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 471856000166 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471856000167 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471856000168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856000169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471856000170 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 471856000171 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 471856000172 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 471856000173 putative dimer interface [polypeptide binding]; other site 471856000174 N-terminal domain interface [polypeptide binding]; other site 471856000175 putative substrate binding pocket (H-site) [chemical binding]; other site 471856000176 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856000177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000178 putative substrate translocation pore; other site 471856000179 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 471856000180 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 471856000181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856000182 FeS/SAM binding site; other site 471856000183 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471856000184 YCII-related domain; Region: YCII; cl00999 471856000185 high affinity sulphate transporter 1; Region: sulP; TIGR00815 471856000186 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471856000187 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471856000188 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471856000189 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 471856000190 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 471856000191 G1 box; other site 471856000192 putative GEF interaction site [polypeptide binding]; other site 471856000193 GTP/Mg2+ binding site [chemical binding]; other site 471856000194 Switch I region; other site 471856000195 G2 box; other site 471856000196 G3 box; other site 471856000197 Switch II region; other site 471856000198 G4 box; other site 471856000199 G5 box; other site 471856000200 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471856000201 DNA binding residues [nucleotide binding] 471856000202 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 471856000203 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471856000204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471856000205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856000206 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856000207 Walker A/P-loop; other site 471856000208 ATP binding site [chemical binding]; other site 471856000209 Q-loop/lid; other site 471856000210 ABC transporter signature motif; other site 471856000211 Walker B; other site 471856000212 D-loop; other site 471856000213 H-loop/switch region; other site 471856000214 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471856000215 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 471856000216 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471856000217 ligand binding site [chemical binding]; other site 471856000218 active site 471856000219 UGI interface [polypeptide binding]; other site 471856000220 catalytic site [active] 471856000221 YKOF-related Family; Region: Ykof; pfam07615 471856000222 YKOF-related Family; Region: Ykof; pfam07615 471856000223 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 471856000224 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856000225 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471856000226 Walker A/P-loop; other site 471856000227 ATP binding site [chemical binding]; other site 471856000228 Q-loop/lid; other site 471856000229 ABC transporter signature motif; other site 471856000230 Walker B; other site 471856000231 D-loop; other site 471856000232 H-loop/switch region; other site 471856000233 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856000234 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471856000235 Walker A/P-loop; other site 471856000236 ATP binding site [chemical binding]; other site 471856000237 Q-loop/lid; other site 471856000238 ABC transporter signature motif; other site 471856000239 Walker B; other site 471856000240 D-loop; other site 471856000241 H-loop/switch region; other site 471856000242 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471856000243 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856000244 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 471856000245 Ligand Binding Site [chemical binding]; other site 471856000246 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471856000247 CPxP motif; other site 471856000248 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 471856000249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000250 Walker A/P-loop; other site 471856000251 ATP binding site [chemical binding]; other site 471856000252 Q-loop/lid; other site 471856000253 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471856000254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000255 Walker A/P-loop; other site 471856000256 ATP binding site [chemical binding]; other site 471856000257 Q-loop/lid; other site 471856000258 ABC transporter signature motif; other site 471856000259 Walker B; other site 471856000260 D-loop; other site 471856000261 H-loop/switch region; other site 471856000262 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471856000263 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 471856000264 NADP binding site [chemical binding]; other site 471856000265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856000266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856000267 DNA binding site [nucleotide binding] 471856000268 domain linker motif; other site 471856000269 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 471856000270 ligand binding site [chemical binding]; other site 471856000271 dimerization interface (open form) [polypeptide binding]; other site 471856000272 dimerization interface (closed form) [polypeptide binding]; other site 471856000273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856000274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856000275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856000276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856000277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000278 dimer interface [polypeptide binding]; other site 471856000279 conserved gate region; other site 471856000280 putative PBP binding loops; other site 471856000281 ABC-ATPase subunit interface; other site 471856000282 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856000283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000284 dimer interface [polypeptide binding]; other site 471856000285 conserved gate region; other site 471856000286 putative PBP binding loops; other site 471856000287 ABC-ATPase subunit interface; other site 471856000288 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 471856000289 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 471856000290 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 471856000291 Prostaglandin dehydrogenases; Region: PGDH; cd05288 471856000292 NAD(P) binding site [chemical binding]; other site 471856000293 substrate binding site [chemical binding]; other site 471856000294 dimer interface [polypeptide binding]; other site 471856000295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856000296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856000297 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471856000298 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 471856000299 active site 471856000300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856000301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856000302 Walker A/P-loop; other site 471856000303 ATP binding site [chemical binding]; other site 471856000304 Q-loop/lid; other site 471856000305 ABC transporter signature motif; other site 471856000306 Walker B; other site 471856000307 D-loop; other site 471856000308 H-loop/switch region; other site 471856000309 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471856000310 FtsX-like permease family; Region: FtsX; pfam02687 471856000311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856000312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856000313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471856000314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471856000315 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 471856000316 putative dimerization interface [polypeptide binding]; other site 471856000317 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471856000318 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471856000319 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 471856000320 putative NAD(P) binding site [chemical binding]; other site 471856000321 putative substrate binding site [chemical binding]; other site 471856000322 catalytic Zn binding site [ion binding]; other site 471856000323 structural Zn binding site [ion binding]; other site 471856000324 dimer interface [polypeptide binding]; other site 471856000325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471856000326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856000327 Walker A/P-loop; other site 471856000328 ATP binding site [chemical binding]; other site 471856000329 Q-loop/lid; other site 471856000330 ABC transporter signature motif; other site 471856000331 Walker B; other site 471856000332 D-loop; other site 471856000333 H-loop/switch region; other site 471856000334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471856000335 Histidine kinase; Region: HisKA_3; pfam07730 471856000336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856000337 ATP binding site [chemical binding]; other site 471856000338 Mg2+ binding site [ion binding]; other site 471856000339 G-X-G motif; other site 471856000340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856000341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856000342 active site 471856000343 phosphorylation site [posttranslational modification] 471856000344 intermolecular recognition site; other site 471856000345 dimerization interface [polypeptide binding]; other site 471856000346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856000347 DNA binding residues [nucleotide binding] 471856000348 dimerization interface [polypeptide binding]; other site 471856000349 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471856000350 putative active site [active] 471856000351 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471856000352 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 471856000353 catalytic triad [active] 471856000354 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471856000355 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 471856000356 active site 471856000357 FMN binding site [chemical binding]; other site 471856000358 substrate binding site [chemical binding]; other site 471856000359 homotetramer interface [polypeptide binding]; other site 471856000360 catalytic residue [active] 471856000361 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471856000362 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 471856000363 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471856000364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471856000365 catalytic residues [active] 471856000366 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 471856000367 active site 471856000368 phosphate binding residues; other site 471856000369 catalytic residues [active] 471856000370 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471856000371 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471856000372 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471856000373 FAD binding domain; Region: FAD_binding_4; pfam01565 471856000374 Berberine and berberine like; Region: BBE; pfam08031 471856000375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856000376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856000377 DNA binding site [nucleotide binding] 471856000378 domain linker motif; other site 471856000379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856000380 dimerization interface [polypeptide binding]; other site 471856000381 ligand binding site [chemical binding]; other site 471856000382 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471856000383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856000384 motif II; other site 471856000385 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 471856000386 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471856000387 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 471856000388 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471856000389 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856000390 Walker A/P-loop; other site 471856000391 ATP binding site [chemical binding]; other site 471856000392 Q-loop/lid; other site 471856000393 ABC transporter signature motif; other site 471856000394 Walker B; other site 471856000395 D-loop; other site 471856000396 H-loop/switch region; other site 471856000397 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856000398 Walker A/P-loop; other site 471856000399 ATP binding site [chemical binding]; other site 471856000400 Q-loop/lid; other site 471856000401 ABC transporter signature motif; other site 471856000402 Walker B; other site 471856000403 D-loop; other site 471856000404 H-loop/switch region; other site 471856000405 Cobalt transport protein; Region: CbiQ; cl00463 471856000406 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471856000407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000408 Walker A/P-loop; other site 471856000409 ATP binding site [chemical binding]; other site 471856000410 Q-loop/lid; other site 471856000411 ABC transporter signature motif; other site 471856000412 Walker B; other site 471856000413 D-loop; other site 471856000414 H-loop/switch region; other site 471856000415 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 471856000416 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471856000417 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 471856000418 NodB motif; other site 471856000419 active site 471856000420 catalytic site [active] 471856000421 metal binding site [ion binding]; metal-binding site 471856000422 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 471856000423 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471856000424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856000425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856000426 short chain dehydrogenase; Provisional; Region: PRK07825 471856000427 classical (c) SDRs; Region: SDR_c; cd05233 471856000428 NAD(P) binding site [chemical binding]; other site 471856000429 active site 471856000430 arginine deiminase; Provisional; Region: PRK01388 471856000431 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471856000432 Domain of unknown function DUF21; Region: DUF21; pfam01595 471856000433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856000434 Transporter associated domain; Region: CorC_HlyC; smart01091 471856000435 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471856000436 Cytochrome P450; Region: p450; cl12078 471856000437 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 471856000438 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 471856000439 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 471856000440 Predicted transcriptional regulator [Transcription]; Region: COG2345 471856000441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856000442 putative DNA binding site [nucleotide binding]; other site 471856000443 putative Zn2+ binding site [ion binding]; other site 471856000444 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 471856000445 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471856000446 putative homotetramer interface [polypeptide binding]; other site 471856000447 putative homodimer interface [polypeptide binding]; other site 471856000448 putative allosteric switch controlling residues; other site 471856000449 putative metal binding site [ion binding]; other site 471856000450 putative homodimer-homodimer interface [polypeptide binding]; other site 471856000451 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 471856000452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856000453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471856000454 active site residue [active] 471856000455 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471856000456 active site 471856000457 DNA binding site [nucleotide binding] 471856000458 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 471856000459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471856000460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471856000461 dimerization interface [polypeptide binding]; other site 471856000462 Lysine efflux permease [General function prediction only]; Region: COG1279 471856000463 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471856000464 active site 471856000465 B-box zinc finger; Region: zf-B_box; pfam00643 471856000466 Zn2+ binding site [ion binding]; other site 471856000467 Rhomboid family; Region: Rhomboid; pfam01694 471856000468 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 471856000469 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471856000470 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471856000471 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471856000472 glutamine binding [chemical binding]; other site 471856000473 catalytic triad [active] 471856000474 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471856000475 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471856000476 active site 471856000477 ATP binding site [chemical binding]; other site 471856000478 substrate binding site [chemical binding]; other site 471856000479 activation loop (A-loop); other site 471856000480 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856000481 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856000482 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856000483 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856000484 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471856000485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471856000486 active site 471856000487 ATP binding site [chemical binding]; other site 471856000488 substrate binding site [chemical binding]; other site 471856000489 activation loop (A-loop); other site 471856000490 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471856000491 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471856000492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471856000493 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471856000494 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471856000495 active site 471856000496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471856000497 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471856000498 phosphopeptide binding site; other site 471856000499 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471856000500 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471856000501 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471856000502 phosphopeptide binding site; other site 471856000503 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471856000504 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471856000505 active site 471856000506 Uncharacterized conserved protein [Function unknown]; Region: COG4850 471856000507 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 471856000508 aspartate aminotransferase; Provisional; Region: PRK05764 471856000509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856000510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856000511 homodimer interface [polypeptide binding]; other site 471856000512 catalytic residue [active] 471856000513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856000514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856000515 DNA binding residues [nucleotide binding] 471856000516 dimerization interface [polypeptide binding]; other site 471856000517 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471856000518 active site 471856000519 8-oxo-dGMP binding site [chemical binding]; other site 471856000520 nudix motif; other site 471856000521 metal binding site [ion binding]; metal-binding site 471856000522 Predicted flavoprotein [General function prediction only]; Region: COG0431 471856000523 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471856000524 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471856000525 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471856000526 Metal-binding active site; metal-binding site 471856000527 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471856000528 substrate binding site [chemical binding]; other site 471856000529 dimer interface [polypeptide binding]; other site 471856000530 ATP binding site [chemical binding]; other site 471856000531 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 471856000532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471856000533 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856000534 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 471856000535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856000536 motif II; other site 471856000537 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471856000538 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 471856000539 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 471856000540 THF binding site; other site 471856000541 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471856000542 substrate binding site [chemical binding]; other site 471856000543 THF binding site; other site 471856000544 zinc-binding site [ion binding]; other site 471856000545 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471856000546 FAD binding site [chemical binding]; other site 471856000547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000548 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471856000549 Walker A/P-loop; other site 471856000550 ATP binding site [chemical binding]; other site 471856000551 Q-loop/lid; other site 471856000552 ABC transporter signature motif; other site 471856000553 Walker B; other site 471856000554 D-loop; other site 471856000555 H-loop/switch region; other site 471856000556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000557 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856000558 Walker A/P-loop; other site 471856000559 ATP binding site [chemical binding]; other site 471856000560 Q-loop/lid; other site 471856000561 ABC transporter signature motif; other site 471856000562 Walker B; other site 471856000563 D-loop; other site 471856000564 H-loop/switch region; other site 471856000565 CsbD-like; Region: CsbD; cl17424 471856000566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000567 putative substrate translocation pore; other site 471856000568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000571 Walker A/P-loop; other site 471856000572 Walker A/P-loop; other site 471856000573 ATP binding site [chemical binding]; other site 471856000574 ATP binding site [chemical binding]; other site 471856000575 Q-loop/lid; other site 471856000576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000577 ABC transporter signature motif; other site 471856000578 Walker B; other site 471856000579 D-loop; other site 471856000580 H-loop/switch region; other site 471856000581 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471856000582 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471856000583 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471856000584 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 471856000585 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471856000586 substrate binding site [chemical binding]; other site 471856000587 THF binding site; other site 471856000588 zinc-binding site [ion binding]; other site 471856000589 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 471856000590 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471856000591 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 471856000592 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 471856000593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856000594 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471856000595 NAD(P) binding site [chemical binding]; other site 471856000596 active site 471856000597 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471856000598 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471856000599 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 471856000600 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471856000601 FAD binding domain; Region: FAD_binding_2; pfam00890 471856000602 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 471856000603 metal binding site [ion binding]; metal-binding site 471856000604 active site 471856000605 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 471856000606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856000607 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856000608 Walker A/P-loop; other site 471856000609 ATP binding site [chemical binding]; other site 471856000610 Q-loop/lid; other site 471856000611 ABC transporter signature motif; other site 471856000612 Walker B; other site 471856000613 D-loop; other site 471856000614 H-loop/switch region; other site 471856000615 FtsX-like permease family; Region: FtsX; pfam02687 471856000616 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471856000617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856000618 Walker A/P-loop; other site 471856000619 ATP binding site [chemical binding]; other site 471856000620 Q-loop/lid; other site 471856000621 ABC transporter signature motif; other site 471856000622 Walker B; other site 471856000623 D-loop; other site 471856000624 H-loop/switch region; other site 471856000625 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471856000626 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471856000627 active site 471856000628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471856000629 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471856000630 active site 471856000631 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856000632 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471856000633 Walker A/P-loop; other site 471856000634 ATP binding site [chemical binding]; other site 471856000635 Q-loop/lid; other site 471856000636 ABC transporter signature motif; other site 471856000637 Walker B; other site 471856000638 D-loop; other site 471856000639 H-loop/switch region; other site 471856000640 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471856000641 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471856000642 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471856000643 GTPase RsgA; Reviewed; Region: PRK01889 471856000644 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471856000645 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471856000646 GTP/Mg2+ binding site [chemical binding]; other site 471856000647 G4 box; other site 471856000648 G5 box; other site 471856000649 G1 box; other site 471856000650 Switch I region; other site 471856000651 G2 box; other site 471856000652 G3 box; other site 471856000653 Switch II region; other site 471856000654 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 471856000655 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471856000656 active site 471856000657 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471856000658 non-specific DNA interactions [nucleotide binding]; other site 471856000659 DNA binding site [nucleotide binding] 471856000660 sequence specific DNA binding site [nucleotide binding]; other site 471856000661 putative cAMP binding site [chemical binding]; other site 471856000662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856000663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856000664 nucleotide binding site [chemical binding]; other site 471856000665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856000666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856000667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000668 dimer interface [polypeptide binding]; other site 471856000669 conserved gate region; other site 471856000670 putative PBP binding loops; other site 471856000671 ABC-ATPase subunit interface; other site 471856000672 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856000673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000674 dimer interface [polypeptide binding]; other site 471856000675 conserved gate region; other site 471856000676 putative PBP binding loops; other site 471856000677 ABC-ATPase subunit interface; other site 471856000678 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471856000679 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471856000680 active site 471856000681 trimer interface [polypeptide binding]; other site 471856000682 allosteric site; other site 471856000683 active site lid [active] 471856000684 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471856000685 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856000686 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856000687 nucleotide binding site [chemical binding]; other site 471856000688 Uncharacterized conserved protein [Function unknown]; Region: COG3189 471856000689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856000690 ATP binding site [chemical binding]; other site 471856000691 putative Mg++ binding site [ion binding]; other site 471856000692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856000693 nucleotide binding region [chemical binding]; other site 471856000694 ATP-binding site [chemical binding]; other site 471856000695 Helicase associated domain (HA2); Region: HA2; pfam04408 471856000696 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471856000697 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471856000698 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471856000699 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471856000700 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471856000701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471856000702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856000703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856000704 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471856000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000706 dimer interface [polypeptide binding]; other site 471856000707 conserved gate region; other site 471856000708 putative PBP binding loops; other site 471856000709 ABC-ATPase subunit interface; other site 471856000710 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471856000711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856000712 Walker A/P-loop; other site 471856000713 ATP binding site [chemical binding]; other site 471856000714 Q-loop/lid; other site 471856000715 ABC transporter signature motif; other site 471856000716 Walker B; other site 471856000717 D-loop; other site 471856000718 H-loop/switch region; other site 471856000719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856000720 Walker A/P-loop; other site 471856000721 ATP binding site [chemical binding]; other site 471856000722 Q-loop/lid; other site 471856000723 ABC transporter signature motif; other site 471856000724 Walker B; other site 471856000725 D-loop; other site 471856000726 H-loop/switch region; other site 471856000727 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471856000728 putative hydrophobic ligand binding site [chemical binding]; other site 471856000729 short chain dehydrogenase; Provisional; Region: PRK06701 471856000730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856000731 NAD(P) binding site [chemical binding]; other site 471856000732 active site 471856000733 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 471856000734 Na2 binding site [ion binding]; other site 471856000735 putative substrate binding site 1 [chemical binding]; other site 471856000736 Na binding site 1 [ion binding]; other site 471856000737 putative substrate binding site 2 [chemical binding]; other site 471856000738 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 471856000739 homodimer interface [polypeptide binding]; other site 471856000740 chemical substrate binding site [chemical binding]; other site 471856000741 oligomer interface [polypeptide binding]; other site 471856000742 metal binding site [ion binding]; metal-binding site 471856000743 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 471856000744 diiron binding motif [ion binding]; other site 471856000745 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 471856000746 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471856000747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856000748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856000749 Coenzyme A binding pocket [chemical binding]; other site 471856000750 phosphoglucomutase; Validated; Region: PRK07564 471856000751 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 471856000752 active site 471856000753 substrate binding site [chemical binding]; other site 471856000754 metal binding site [ion binding]; metal-binding site 471856000755 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471856000756 active site 471856000757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856000758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471856000759 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471856000760 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471856000761 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471856000762 seryl-tRNA synthetase; Provisional; Region: PRK05431 471856000763 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471856000764 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471856000765 dimer interface [polypeptide binding]; other site 471856000766 active site 471856000767 motif 1; other site 471856000768 motif 2; other site 471856000769 motif 3; other site 471856000770 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471856000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856000772 active site 471856000773 motif I; other site 471856000774 motif II; other site 471856000775 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856000776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000777 dimer interface [polypeptide binding]; other site 471856000778 conserved gate region; other site 471856000779 putative PBP binding loops; other site 471856000780 ABC-ATPase subunit interface; other site 471856000781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856000782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000783 dimer interface [polypeptide binding]; other site 471856000784 conserved gate region; other site 471856000785 putative PBP binding loops; other site 471856000786 ABC-ATPase subunit interface; other site 471856000787 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 471856000788 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471856000789 NAD(P) binding site [chemical binding]; other site 471856000790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471856000791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856000792 dimerization interface [polypeptide binding]; other site 471856000793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856000794 ATP binding site [chemical binding]; other site 471856000795 Mg2+ binding site [ion binding]; other site 471856000796 G-X-G motif; other site 471856000797 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 471856000798 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471856000799 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471856000800 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471856000801 G1 box; other site 471856000802 GTP/Mg2+ binding site [chemical binding]; other site 471856000803 G2 box; other site 471856000804 Switch I region; other site 471856000805 G3 box; other site 471856000806 Switch II region; other site 471856000807 G4 box; other site 471856000808 G5 box; other site 471856000809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856000810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856000811 DNA binding site [nucleotide binding] 471856000812 domain linker motif; other site 471856000813 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 471856000814 ligand binding site [chemical binding]; other site 471856000815 dimerization interface (open form) [polypeptide binding]; other site 471856000816 dimerization interface (closed form) [polypeptide binding]; other site 471856000817 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471856000818 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471856000819 Walker A/P-loop; other site 471856000820 ATP binding site [chemical binding]; other site 471856000821 Q-loop/lid; other site 471856000822 ABC transporter signature motif; other site 471856000823 Walker B; other site 471856000824 D-loop; other site 471856000825 H-loop/switch region; other site 471856000826 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471856000827 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471856000828 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471856000829 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471856000830 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471856000831 Walker A/P-loop; other site 471856000832 ATP binding site [chemical binding]; other site 471856000833 Q-loop/lid; other site 471856000834 ABC transporter signature motif; other site 471856000835 Walker B; other site 471856000836 D-loop; other site 471856000837 H-loop/switch region; other site 471856000838 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471856000839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471856000840 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471856000841 TM-ABC transporter signature motif; other site 471856000842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471856000843 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471856000844 TM-ABC transporter signature motif; other site 471856000845 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 471856000846 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471856000847 active site 471856000848 catalytic site [active] 471856000849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 471856000850 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471856000851 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 471856000852 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 471856000853 Domain of unknown function (DUF305); Region: DUF305; cl17794 471856000854 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471856000855 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471856000856 putative NAD(P) binding site [chemical binding]; other site 471856000857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856000859 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471856000860 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471856000861 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471856000862 DNA binding site [nucleotide binding] 471856000863 active site 471856000864 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471856000865 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471856000866 BCCT family transporter; Region: BCCT; pfam02028 471856000867 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471856000868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856000869 Putative zinc-finger; Region: zf-HC2; pfam13490 471856000870 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471856000871 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 471856000872 metal binding site [ion binding]; metal-binding site 471856000873 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471856000874 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471856000875 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471856000876 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856000877 ABC-ATPase subunit interface; other site 471856000878 dimer interface [polypeptide binding]; other site 471856000879 putative PBP binding regions; other site 471856000880 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471856000881 DNA-binding site [nucleotide binding]; DNA binding site 471856000882 RNA-binding motif; other site 471856000883 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856000884 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471856000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856000886 putative substrate translocation pore; other site 471856000887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856000888 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 471856000889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 471856000890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471856000891 putative metal binding site [ion binding]; other site 471856000892 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471856000893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471856000894 active site 471856000895 metal binding site [ion binding]; metal-binding site 471856000896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856000897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856000898 DNA binding site [nucleotide binding] 471856000899 domain linker motif; other site 471856000900 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471856000901 putative dimerization interface [polypeptide binding]; other site 471856000902 putative ligand binding site [chemical binding]; other site 471856000903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856000904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000905 dimer interface [polypeptide binding]; other site 471856000906 conserved gate region; other site 471856000907 putative PBP binding loops; other site 471856000908 ABC-ATPase subunit interface; other site 471856000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000910 dimer interface [polypeptide binding]; other site 471856000911 conserved gate region; other site 471856000912 putative PBP binding loops; other site 471856000913 ABC-ATPase subunit interface; other site 471856000914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856000915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856000916 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471856000917 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471856000918 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471856000919 Nuclease-related domain; Region: NERD; pfam08378 471856000920 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 471856000921 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 471856000922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471856000923 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 471856000924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000925 dimer interface [polypeptide binding]; other site 471856000926 conserved gate region; other site 471856000927 putative PBP binding loops; other site 471856000928 ABC-ATPase subunit interface; other site 471856000929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856000930 dimer interface [polypeptide binding]; other site 471856000931 conserved gate region; other site 471856000932 putative PBP binding loops; other site 471856000933 ABC-ATPase subunit interface; other site 471856000934 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 471856000935 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 471856000936 Walker A/P-loop; other site 471856000937 ATP binding site [chemical binding]; other site 471856000938 Q-loop/lid; other site 471856000939 ABC transporter signature motif; other site 471856000940 Walker B; other site 471856000941 D-loop; other site 471856000942 H-loop/switch region; other site 471856000943 Protein of unknown function, DUF488; Region: DUF488; pfam04343 471856000944 Domain of unknown function DUF21; Region: DUF21; pfam01595 471856000945 hypothetical protein; Provisional; Region: PRK11573 471856000946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856000947 Transporter associated domain; Region: CorC_HlyC; pfam03471 471856000948 Domain of unknown function DUF21; Region: DUF21; pfam01595 471856000949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856000950 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471856000951 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 471856000952 putative active site [active] 471856000953 putative metal binding residues [ion binding]; other site 471856000954 signature motif; other site 471856000955 putative triphosphate binding site [ion binding]; other site 471856000956 dimer interface [polypeptide binding]; other site 471856000957 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 471856000958 substrate binding pocket [chemical binding]; other site 471856000959 catalytic residues [active] 471856000960 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 471856000961 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 471856000962 putative sugar binding sites [chemical binding]; other site 471856000963 Q-X-W motif; other site 471856000964 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471856000965 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 471856000966 CCC1-related family of proteins; Region: CCC1_like; cl00278 471856000967 CCC1-related family of proteins; Region: CCC1_like; cl00278 471856000968 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471856000969 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 471856000970 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 471856000971 Pectate lyase; Region: Pectate_lyase; pfam03211 471856000972 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471856000973 Peptidase family M23; Region: Peptidase_M23; pfam01551 471856000974 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 471856000975 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 471856000976 Protein of unknown function (DUF418); Region: DUF418; cl12135 471856000977 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 471856000978 MMPL family; Region: MMPL; pfam03176 471856000979 prenyltransferase; Reviewed; Region: ubiA; PRK13105 471856000980 UbiA prenyltransferase family; Region: UbiA; pfam01040 471856000981 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471856000982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471856000983 phytoene desaturase; Region: crtI_fam; TIGR02734 471856000984 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471856000985 active site lid residues [active] 471856000986 substrate binding pocket [chemical binding]; other site 471856000987 catalytic residues [active] 471856000988 substrate-Mg2+ binding site; other site 471856000989 aspartate-rich region 1; other site 471856000990 aspartate-rich region 2; other site 471856000991 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471856000992 substrate binding pocket [chemical binding]; other site 471856000993 chain length determination region; other site 471856000994 substrate-Mg2+ binding site; other site 471856000995 catalytic residues [active] 471856000996 aspartate-rich region 1; other site 471856000997 active site lid residues [active] 471856000998 aspartate-rich region 2; other site 471856000999 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471856001000 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 471856001001 active site 471856001002 metal binding site [ion binding]; metal-binding site 471856001003 nudix motif; other site 471856001004 MarR family; Region: MarR_2; pfam12802 471856001005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856001006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856001007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856001008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856001009 Walker A/P-loop; other site 471856001010 ATP binding site [chemical binding]; other site 471856001011 Q-loop/lid; other site 471856001012 ABC transporter signature motif; other site 471856001013 Walker B; other site 471856001014 D-loop; other site 471856001015 H-loop/switch region; other site 471856001016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856001017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856001018 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471856001019 Walker A/P-loop; other site 471856001020 ATP binding site [chemical binding]; other site 471856001021 Q-loop/lid; other site 471856001022 ABC transporter signature motif; other site 471856001023 Walker B; other site 471856001024 D-loop; other site 471856001025 H-loop/switch region; other site 471856001026 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471856001027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856001028 nucleotide binding site [chemical binding]; other site 471856001029 GrpE; Region: GrpE; pfam01025 471856001030 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471856001031 dimer interface [polypeptide binding]; other site 471856001032 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471856001033 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 471856001034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471856001035 HSP70 interaction site [polypeptide binding]; other site 471856001036 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471856001037 substrate binding site [polypeptide binding]; other site 471856001038 dimer interface [polypeptide binding]; other site 471856001039 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471856001040 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471856001041 DNA binding residues [nucleotide binding] 471856001042 putative dimer interface [polypeptide binding]; other site 471856001043 Phosphotransferase enzyme family; Region: APH; pfam01636 471856001044 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471856001045 active site 471856001046 substrate binding site [chemical binding]; other site 471856001047 ATP binding site [chemical binding]; other site 471856001048 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 471856001049 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856001050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856001051 DNA binding site [nucleotide binding] 471856001052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856001053 active site 471856001054 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471856001055 nucleoside/Zn binding site; other site 471856001056 dimer interface [polypeptide binding]; other site 471856001057 catalytic motif [active] 471856001058 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471856001059 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471856001060 synthetase active site [active] 471856001061 NTP binding site [chemical binding]; other site 471856001062 metal binding site [ion binding]; metal-binding site 471856001063 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471856001064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856001065 dimer interface [polypeptide binding]; other site 471856001066 putative CheW interface [polypeptide binding]; other site 471856001067 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471856001068 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856001069 dimer interface [polypeptide binding]; other site 471856001070 putative CheW interface [polypeptide binding]; other site 471856001071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856001072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856001073 DNA binding site [nucleotide binding] 471856001074 domain linker motif; other site 471856001075 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856001076 ligand binding site [chemical binding]; other site 471856001077 dimerization interface [polypeptide binding]; other site 471856001078 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471856001079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471856001080 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471856001081 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471856001082 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471856001083 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471856001084 active site 471856001085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856001086 dimerization interface [polypeptide binding]; other site 471856001087 putative DNA binding site [nucleotide binding]; other site 471856001088 putative Zn2+ binding site [ion binding]; other site 471856001089 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471856001090 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471856001091 active site 471856001092 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 471856001093 arsenical-resistance protein; Region: acr3; TIGR00832 471856001094 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471856001095 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 471856001096 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471856001097 active site 471856001098 dimer interface [polypeptide binding]; other site 471856001099 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471856001100 dimer interface [polypeptide binding]; other site 471856001101 active site 471856001102 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471856001103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856001104 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856001105 Walker A/P-loop; other site 471856001106 ATP binding site [chemical binding]; other site 471856001107 Q-loop/lid; other site 471856001108 ABC transporter signature motif; other site 471856001109 Walker B; other site 471856001110 D-loop; other site 471856001111 H-loop/switch region; other site 471856001112 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471856001113 FtsX-like permease family; Region: FtsX; pfam02687 471856001114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856001115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856001116 DNA binding site [nucleotide binding] 471856001117 domain linker motif; other site 471856001118 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471856001119 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471856001120 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471856001121 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471856001122 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471856001123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856001124 dimer interface [polypeptide binding]; other site 471856001125 conserved gate region; other site 471856001126 ABC-ATPase subunit interface; other site 471856001127 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856001128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856001129 dimer interface [polypeptide binding]; other site 471856001130 conserved gate region; other site 471856001131 putative PBP binding loops; other site 471856001132 ABC-ATPase subunit interface; other site 471856001133 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856001134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856001135 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471856001136 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856001137 Walker A/P-loop; other site 471856001138 ATP binding site [chemical binding]; other site 471856001139 Q-loop/lid; other site 471856001140 ABC transporter signature motif; other site 471856001141 Walker B; other site 471856001142 D-loop; other site 471856001143 H-loop/switch region; other site 471856001144 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471856001145 Domain of unknown function (DUF202); Region: DUF202; cl09954 471856001146 Domain of unknown function (DUF202); Region: DUF202; pfam02656 471856001147 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 471856001148 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 471856001149 Domain of unknown function (DUF368); Region: DUF368; pfam04018 471856001150 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471856001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001152 putative substrate translocation pore; other site 471856001153 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471856001154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856001155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856001156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856001158 putative substrate translocation pore; other site 471856001159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001160 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471856001161 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471856001162 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471856001163 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 471856001164 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471856001165 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 471856001166 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471856001167 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 471856001168 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 471856001169 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 471856001170 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856001171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856001172 Walker A/P-loop; other site 471856001173 ATP binding site [chemical binding]; other site 471856001174 Q-loop/lid; other site 471856001175 ABC transporter signature motif; other site 471856001176 Walker B; other site 471856001177 D-loop; other site 471856001178 H-loop/switch region; other site 471856001179 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471856001180 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471856001181 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471856001182 Walker A/P-loop; other site 471856001183 ATP binding site [chemical binding]; other site 471856001184 Q-loop/lid; other site 471856001185 ABC transporter signature motif; other site 471856001186 Walker B; other site 471856001187 D-loop; other site 471856001188 H-loop/switch region; other site 471856001189 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 471856001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856001191 dimer interface [polypeptide binding]; other site 471856001192 conserved gate region; other site 471856001193 putative PBP binding loops; other site 471856001194 ABC-ATPase subunit interface; other site 471856001195 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471856001196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856001197 Walker A motif; other site 471856001198 ATP binding site [chemical binding]; other site 471856001199 Walker B motif; other site 471856001200 arginine finger; other site 471856001201 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471856001202 recombination protein RecR; Reviewed; Region: recR; PRK00076 471856001203 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471856001204 RecR protein; Region: RecR; pfam02132 471856001205 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471856001206 putative active site [active] 471856001207 putative metal-binding site [ion binding]; other site 471856001208 tetramer interface [polypeptide binding]; other site 471856001209 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471856001210 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471856001211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856001212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856001213 Walker A/P-loop; other site 471856001214 ATP binding site [chemical binding]; other site 471856001215 Q-loop/lid; other site 471856001216 ABC transporter signature motif; other site 471856001217 Walker B; other site 471856001218 D-loop; other site 471856001219 H-loop/switch region; other site 471856001220 aspartate kinase; Reviewed; Region: PRK06635 471856001221 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471856001222 putative nucleotide binding site [chemical binding]; other site 471856001223 putative catalytic residues [active] 471856001224 putative Mg ion binding site [ion binding]; other site 471856001225 putative aspartate binding site [chemical binding]; other site 471856001226 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471856001227 putative allosteric regulatory site; other site 471856001228 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 471856001229 putative allosteric regulatory residue; other site 471856001230 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471856001231 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471856001232 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471856001233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856001234 dimerization interface [polypeptide binding]; other site 471856001235 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471856001236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856001237 dimer interface [polypeptide binding]; other site 471856001238 putative CheW interface [polypeptide binding]; other site 471856001239 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 471856001240 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471856001241 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471856001242 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471856001243 FAD binding pocket [chemical binding]; other site 471856001244 FAD binding motif [chemical binding]; other site 471856001245 phosphate binding motif [ion binding]; other site 471856001246 NAD binding pocket [chemical binding]; other site 471856001247 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471856001248 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471856001249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856001250 dimer interface [polypeptide binding]; other site 471856001251 putative PBP binding regions; other site 471856001252 ABC-ATPase subunit interface; other site 471856001253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856001254 dimer interface [polypeptide binding]; other site 471856001255 putative PBP binding regions; other site 471856001256 ABC-ATPase subunit interface; other site 471856001257 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471856001258 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471856001259 Walker A/P-loop; other site 471856001260 ATP binding site [chemical binding]; other site 471856001261 Q-loop/lid; other site 471856001262 ABC transporter signature motif; other site 471856001263 Walker B; other site 471856001264 D-loop; other site 471856001265 H-loop/switch region; other site 471856001266 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471856001267 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471856001268 intersubunit interface [polypeptide binding]; other site 471856001269 HIRAN domain; Region: HIRAN; cl07418 471856001270 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471856001271 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471856001272 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471856001273 active site 471856001274 metal binding site [ion binding]; metal-binding site 471856001275 Transglycosylase; Region: Transgly; pfam00912 471856001276 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471856001277 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471856001278 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 471856001279 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471856001280 homotrimer interaction site [polypeptide binding]; other site 471856001281 putative active site [active] 471856001282 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471856001283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471856001284 ligand binding site [chemical binding]; other site 471856001285 flexible hinge region; other site 471856001286 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471856001287 putative switch regulator; other site 471856001288 non-specific DNA interactions [nucleotide binding]; other site 471856001289 DNA binding site [nucleotide binding] 471856001290 sequence specific DNA binding site [nucleotide binding]; other site 471856001291 putative cAMP binding site [chemical binding]; other site 471856001292 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471856001293 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471856001294 minor groove reading motif; other site 471856001295 helix-hairpin-helix signature motif; other site 471856001296 substrate binding pocket [chemical binding]; other site 471856001297 active site 471856001298 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471856001299 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856001300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856001301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856001302 DNA binding site [nucleotide binding] 471856001303 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 471856001304 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471856001305 heme-binding site [chemical binding]; other site 471856001306 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471856001307 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471856001308 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471856001309 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 471856001310 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471856001311 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471856001312 putative active site [active] 471856001313 dimerization interface [polypeptide binding]; other site 471856001314 putative tRNAtyr binding site [nucleotide binding]; other site 471856001315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471856001316 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471856001317 Clp protease ATP binding subunit; Region: clpC; CHL00095 471856001318 Clp amino terminal domain; Region: Clp_N; pfam02861 471856001319 Clp amino terminal domain; Region: Clp_N; pfam02861 471856001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856001321 Walker A motif; other site 471856001322 ATP binding site [chemical binding]; other site 471856001323 Walker B motif; other site 471856001324 arginine finger; other site 471856001325 UvrB/uvrC motif; Region: UVR; pfam02151 471856001326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856001327 Walker A motif; other site 471856001328 ATP binding site [chemical binding]; other site 471856001329 Walker B motif; other site 471856001330 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471856001331 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471856001332 active site 471856001333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856001334 dimerization interface [polypeptide binding]; other site 471856001335 putative DNA binding site [nucleotide binding]; other site 471856001336 putative Zn2+ binding site [ion binding]; other site 471856001337 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 471856001338 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471856001339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856001340 DNA-binding site [nucleotide binding]; DNA binding site 471856001341 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471856001342 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471856001343 phosphopeptide binding site; other site 471856001344 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471856001345 Protein phosphatase 2C; Region: PP2C; pfam00481 471856001346 active site 471856001347 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471856001348 phosphopeptide binding site; other site 471856001349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471856001350 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471856001351 active site 471856001352 ATP binding site [chemical binding]; other site 471856001353 substrate binding site [chemical binding]; other site 471856001354 activation loop (A-loop); other site 471856001355 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471856001356 Interdomain contacts; other site 471856001357 Cytokine receptor motif; other site 471856001358 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471856001359 Interdomain contacts; other site 471856001360 Cytokine receptor motif; other site 471856001361 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471856001362 Interdomain contacts; other site 471856001363 Cytokine receptor motif; other site 471856001364 MoxR-like ATPases [General function prediction only]; Region: COG0714 471856001365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856001366 Walker A motif; other site 471856001367 ATP binding site [chemical binding]; other site 471856001368 Walker B motif; other site 471856001369 arginine finger; other site 471856001370 Protein of unknown function DUF58; Region: DUF58; pfam01882 471856001371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471856001372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471856001373 active site 471856001374 catalytic tetrad [active] 471856001375 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471856001376 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856001377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856001378 xylose isomerase; Provisional; Region: PRK12677 471856001379 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 471856001380 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856001381 D-xylulose kinase; Region: XylB; TIGR01312 471856001382 nucleotide binding site [chemical binding]; other site 471856001383 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471856001384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856001385 active site 471856001386 phosphorylation site [posttranslational modification] 471856001387 intermolecular recognition site; other site 471856001388 dimerization interface [polypeptide binding]; other site 471856001389 LytTr DNA-binding domain; Region: LytTR; pfam04397 471856001390 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 471856001391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856001392 ATP binding site [chemical binding]; other site 471856001393 Mg2+ binding site [ion binding]; other site 471856001394 G-X-G motif; other site 471856001395 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471856001396 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471856001397 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471856001398 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471856001399 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471856001400 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471856001401 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471856001402 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 471856001403 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471856001404 NAD(P) binding site [chemical binding]; other site 471856001405 putative active site [active] 471856001406 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 471856001407 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471856001408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856001409 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856001410 Walker A/P-loop; other site 471856001411 ATP binding site [chemical binding]; other site 471856001412 Q-loop/lid; other site 471856001413 ABC transporter signature motif; other site 471856001414 Walker B; other site 471856001415 D-loop; other site 471856001416 H-loop/switch region; other site 471856001417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471856001418 FtsX-like permease family; Region: FtsX; pfam02687 471856001419 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471856001420 Predicted membrane protein [Function unknown]; Region: COG1511 471856001421 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471856001422 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471856001423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856001424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856001425 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 471856001426 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 471856001427 active site 471856001428 DNA binding site [nucleotide binding] 471856001429 catalytic site [active] 471856001430 glycerol kinase; Provisional; Region: glpK; PRK00047 471856001431 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471856001432 N- and C-terminal domain interface [polypeptide binding]; other site 471856001433 active site 471856001434 MgATP binding site [chemical binding]; other site 471856001435 catalytic site [active] 471856001436 metal binding site [ion binding]; metal-binding site 471856001437 putative homotetramer interface [polypeptide binding]; other site 471856001438 glycerol binding site [chemical binding]; other site 471856001439 homodimer interface [polypeptide binding]; other site 471856001440 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 471856001441 amphipathic channel; other site 471856001442 Asn-Pro-Ala signature motifs; other site 471856001443 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471856001444 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471856001445 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 471856001446 DNA binding site [nucleotide binding] 471856001447 sequence specific DNA binding site [nucleotide binding]; other site 471856001448 putative cAMP binding site [chemical binding]; other site 471856001449 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471856001450 N-acetylglutamate synthase; Validated; Region: PRK07922 471856001451 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 471856001452 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471856001453 minor groove reading motif; other site 471856001454 helix-hairpin-helix signature motif; other site 471856001455 active site 471856001456 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471856001457 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 471856001458 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471856001459 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 471856001460 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471856001461 DNA repair protein RadA; Provisional; Region: PRK11823 471856001462 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471856001463 Walker A motif; other site 471856001464 ATP binding site [chemical binding]; other site 471856001465 Walker B motif; other site 471856001466 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471856001467 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856001468 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856001469 DNA binding site [nucleotide binding] 471856001470 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 471856001471 ligand binding site [chemical binding]; other site 471856001472 dimerization interface (open form) [polypeptide binding]; other site 471856001473 dimerization interface (closed form) [polypeptide binding]; other site 471856001474 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 471856001475 putative N- and C-terminal domain interface [polypeptide binding]; other site 471856001476 D-xylulose kinase; Region: XylB; TIGR01312 471856001477 putative active site [active] 471856001478 MgATP binding site [chemical binding]; other site 471856001479 catalytic site [active] 471856001480 metal binding site [ion binding]; metal-binding site 471856001481 putative carbohydrate binding site [chemical binding]; other site 471856001482 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 471856001483 intersubunit interface [polypeptide binding]; other site 471856001484 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 471856001485 active site 471856001486 Zn2+ binding site [ion binding]; other site 471856001487 L-arabinose isomerase; Provisional; Region: PRK02929 471856001488 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 471856001489 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 471856001490 trimer interface [polypeptide binding]; other site 471856001491 putative substrate binding site [chemical binding]; other site 471856001492 putative metal binding site [ion binding]; other site 471856001493 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471856001494 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471856001495 putative ligand binding site [chemical binding]; other site 471856001496 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 471856001497 active site 471856001498 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471856001499 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471856001500 putative ligand binding site [chemical binding]; other site 471856001501 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 471856001502 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471856001503 Walker A/P-loop; other site 471856001504 ATP binding site [chemical binding]; other site 471856001505 Q-loop/lid; other site 471856001506 ABC transporter signature motif; other site 471856001507 Walker B; other site 471856001508 D-loop; other site 471856001509 H-loop/switch region; other site 471856001510 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471856001511 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471856001512 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471856001513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471856001514 TM-ABC transporter signature motif; other site 471856001515 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471856001516 TrkA-N domain; Region: TrkA_N; pfam02254 471856001517 TrkA-C domain; Region: TrkA_C; pfam02080 471856001518 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 471856001519 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471856001520 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 471856001521 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471856001522 active site 471856001523 Zn binding site [ion binding]; other site 471856001524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856001525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856001526 DNA binding site [nucleotide binding] 471856001527 domain linker motif; other site 471856001528 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856001529 dimerization interface [polypeptide binding]; other site 471856001530 ligand binding site [chemical binding]; other site 471856001531 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471856001532 substrate binding site [chemical binding]; other site 471856001533 active site 471856001534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856001535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856001536 dimer interface [polypeptide binding]; other site 471856001537 conserved gate region; other site 471856001538 putative PBP binding loops; other site 471856001539 ABC-ATPase subunit interface; other site 471856001540 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471856001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856001542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856001543 putative PBP binding loops; other site 471856001544 dimer interface [polypeptide binding]; other site 471856001545 ABC-ATPase subunit interface; other site 471856001546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856001547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856001548 alpha-galactosidase; Region: PLN02808; cl17638 471856001549 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471856001550 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 471856001551 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471856001552 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471856001553 substrate binding site [chemical binding]; other site 471856001554 active site 471856001555 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 471856001556 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471856001557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856001558 MarR family; Region: MarR; pfam01047 471856001559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471856001560 catalytic core [active] 471856001561 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471856001562 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471856001563 catalytic residues [active] 471856001564 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471856001565 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471856001566 ResB-like family; Region: ResB; pfam05140 471856001567 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471856001568 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 471856001569 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 471856001570 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 471856001571 UbiA prenyltransferase family; Region: UbiA; pfam01040 471856001572 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 471856001573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471856001574 AMP binding site [chemical binding]; other site 471856001575 active site 471856001576 acyl-activating enzyme (AAE) consensus motif; other site 471856001577 CoA binding site [chemical binding]; other site 471856001578 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471856001579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471856001580 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471856001581 substrate binding site [chemical binding]; other site 471856001582 oxyanion hole (OAH) forming residues; other site 471856001583 trimer interface [polypeptide binding]; other site 471856001584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856001585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856001586 O-succinylbenzoate synthase; Provisional; Region: PRK02901 471856001587 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 471856001588 active site 471856001589 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471856001590 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471856001591 dimer interface [polypeptide binding]; other site 471856001592 tetramer interface [polypeptide binding]; other site 471856001593 PYR/PP interface [polypeptide binding]; other site 471856001594 TPP binding site [chemical binding]; other site 471856001595 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471856001596 TPP-binding site; other site 471856001597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471856001598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471856001599 protein binding site [polypeptide binding]; other site 471856001600 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471856001601 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471856001602 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471856001603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856001604 S-adenosylmethionine binding site [chemical binding]; other site 471856001605 Cellulose binding domain; Region: CBM_2; pfam00553 471856001606 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 471856001607 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471856001608 NADH dehydrogenase subunit B; Validated; Region: PRK06411 471856001609 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 471856001610 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 471856001611 NADH dehydrogenase subunit D; Validated; Region: PRK06075 471856001612 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 471856001613 NADH dehydrogenase subunit E; Validated; Region: PRK07539 471856001614 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471856001615 putative dimer interface [polypeptide binding]; other site 471856001616 [2Fe-2S] cluster binding site [ion binding]; other site 471856001617 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471856001618 SLBB domain; Region: SLBB; pfam10531 471856001619 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 471856001620 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471856001621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471856001622 catalytic loop [active] 471856001623 iron binding site [ion binding]; other site 471856001624 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471856001625 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471856001626 molybdopterin cofactor binding site; other site 471856001627 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471856001628 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471856001629 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 471856001630 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471856001631 4Fe-4S binding domain; Region: Fer4; pfam00037 471856001632 4Fe-4S binding domain; Region: Fer4; pfam00037 471856001633 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471856001634 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471856001635 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471856001636 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471856001637 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471856001638 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856001639 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471856001640 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856001641 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471856001642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856001643 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471856001644 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471856001645 substrate binding pocket [chemical binding]; other site 471856001646 chain length determination region; other site 471856001647 substrate-Mg2+ binding site; other site 471856001648 catalytic residues [active] 471856001649 aspartate-rich region 1; other site 471856001650 active site lid residues [active] 471856001651 aspartate-rich region 2; other site 471856001652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 471856001653 phosphopeptide binding site; other site 471856001654 ferredoxin-NADP+ reductase; Region: PLN02852 471856001655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471856001656 heat shock protein HtpX; Provisional; Region: PRK03072 471856001657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856001658 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471856001659 active site 471856001660 motif I; other site 471856001661 motif II; other site 471856001662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856001663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 471856001664 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 471856001665 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471856001666 active site 471856001667 catalytic site [active] 471856001668 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471856001669 active site 2 [active] 471856001670 active site 1 [active] 471856001671 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856001672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856001673 DNA binding site [nucleotide binding] 471856001674 domain linker motif; other site 471856001675 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471856001676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471856001680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001681 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471856001682 FAD binding domain; Region: FAD_binding_4; pfam01565 471856001683 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471856001684 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 471856001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856001686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856001687 Predicted transcriptional regulators [Transcription]; Region: COG1725 471856001688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856001689 DNA-binding site [nucleotide binding]; DNA binding site 471856001690 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 471856001691 adenosine deaminase; Provisional; Region: PRK09358 471856001692 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471856001693 active site 471856001694 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 471856001695 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 471856001696 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471856001697 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471856001698 putative homodimer interface [polypeptide binding]; other site 471856001699 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471856001700 heterodimer interface [polypeptide binding]; other site 471856001701 homodimer interface [polypeptide binding]; other site 471856001702 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471856001703 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471856001704 23S rRNA interface [nucleotide binding]; other site 471856001705 L7/L12 interface [polypeptide binding]; other site 471856001706 putative thiostrepton binding site; other site 471856001707 L25 interface [polypeptide binding]; other site 471856001708 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471856001709 mRNA/rRNA interface [nucleotide binding]; other site 471856001710 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471856001711 23S rRNA interface [nucleotide binding]; other site 471856001712 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471856001713 core dimer interface [polypeptide binding]; other site 471856001714 peripheral dimer interface [polypeptide binding]; other site 471856001715 L10 interface [polypeptide binding]; other site 471856001716 L11 interface [polypeptide binding]; other site 471856001717 putative EF-Tu interaction site [polypeptide binding]; other site 471856001718 putative EF-G interaction site [polypeptide binding]; other site 471856001719 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471856001720 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471856001721 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471856001722 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471856001723 RPB10 interaction site [polypeptide binding]; other site 471856001724 RPB1 interaction site [polypeptide binding]; other site 471856001725 RPB11 interaction site [polypeptide binding]; other site 471856001726 RPB3 interaction site [polypeptide binding]; other site 471856001727 RPB12 interaction site [polypeptide binding]; other site 471856001728 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471856001729 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471856001730 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471856001731 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471856001732 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471856001733 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471856001734 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471856001735 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471856001736 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471856001737 G-loop; other site 471856001738 DNA binding site [nucleotide binding] 471856001739 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471856001740 S17 interaction site [polypeptide binding]; other site 471856001741 S8 interaction site; other site 471856001742 16S rRNA interaction site [nucleotide binding]; other site 471856001743 streptomycin interaction site [chemical binding]; other site 471856001744 23S rRNA interaction site [nucleotide binding]; other site 471856001745 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471856001746 30S ribosomal protein S7; Validated; Region: PRK05302 471856001747 elongation factor G; Reviewed; Region: PRK00007 471856001748 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471856001749 G1 box; other site 471856001750 putative GEF interaction site [polypeptide binding]; other site 471856001751 GTP/Mg2+ binding site [chemical binding]; other site 471856001752 Switch I region; other site 471856001753 G2 box; other site 471856001754 G3 box; other site 471856001755 Switch II region; other site 471856001756 G4 box; other site 471856001757 G5 box; other site 471856001758 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471856001759 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471856001760 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471856001761 elongation factor Tu; Reviewed; Region: PRK00049 471856001762 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471856001763 G1 box; other site 471856001764 GEF interaction site [polypeptide binding]; other site 471856001765 GTP/Mg2+ binding site [chemical binding]; other site 471856001766 Switch I region; other site 471856001767 G2 box; other site 471856001768 G3 box; other site 471856001769 Switch II region; other site 471856001770 G4 box; other site 471856001771 G5 box; other site 471856001772 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471856001773 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471856001774 Antibiotic Binding Site [chemical binding]; other site 471856001775 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471856001776 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471856001777 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471856001778 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471856001779 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471856001780 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471856001781 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471856001782 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471856001783 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471856001784 putative translocon binding site; other site 471856001785 protein-rRNA interface [nucleotide binding]; other site 471856001786 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471856001787 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471856001788 G-X-X-G motif; other site 471856001789 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471856001790 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471856001791 23S rRNA interface [nucleotide binding]; other site 471856001792 5S rRNA interface [nucleotide binding]; other site 471856001793 putative antibiotic binding site [chemical binding]; other site 471856001794 L25 interface [polypeptide binding]; other site 471856001795 L27 interface [polypeptide binding]; other site 471856001796 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471856001797 L23 interface [polypeptide binding]; other site 471856001798 signal recognition particle (SRP54) interaction site; other site 471856001799 trigger factor interaction site; other site 471856001800 23S rRNA interface [nucleotide binding]; other site 471856001801 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471856001802 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471856001803 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471856001804 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471856001805 RNA binding site [nucleotide binding]; other site 471856001806 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471856001807 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471856001808 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471856001809 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 471856001810 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471856001811 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471856001812 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471856001813 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471856001814 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471856001815 5S rRNA interface [nucleotide binding]; other site 471856001816 L27 interface [polypeptide binding]; other site 471856001817 23S rRNA interface [nucleotide binding]; other site 471856001818 L5 interface [polypeptide binding]; other site 471856001819 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471856001820 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471856001821 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471856001822 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471856001823 23S rRNA binding site [nucleotide binding]; other site 471856001824 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471856001825 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471856001826 SecY translocase; Region: SecY; pfam00344 471856001827 adenylate kinase; Reviewed; Region: adk; PRK00279 471856001828 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471856001829 AMP-binding site [chemical binding]; other site 471856001830 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471856001831 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471856001832 rRNA binding site [nucleotide binding]; other site 471856001833 predicted 30S ribosome binding site; other site 471856001834 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 471856001835 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471856001836 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471856001837 30S ribosomal protein S11; Validated; Region: PRK05309 471856001838 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471856001839 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471856001840 alphaNTD - beta interaction site [polypeptide binding]; other site 471856001841 alphaNTD homodimer interface [polypeptide binding]; other site 471856001842 alphaNTD - beta' interaction site [polypeptide binding]; other site 471856001843 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471856001844 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471856001845 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471856001846 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471856001847 dimerization interface 3.5A [polypeptide binding]; other site 471856001848 active site 471856001849 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 471856001850 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 471856001851 active site residue [active] 471856001852 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471856001853 23S rRNA interface [nucleotide binding]; other site 471856001854 L3 interface [polypeptide binding]; other site 471856001855 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471856001856 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471856001857 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471856001858 active site 471856001859 substrate binding site [chemical binding]; other site 471856001860 metal binding site [ion binding]; metal-binding site 471856001861 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471856001862 active site 471856001863 catalytic residues [active] 471856001864 metal binding site [ion binding]; metal-binding site 471856001865 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471856001866 pantothenate kinase; Provisional; Region: PRK05439 471856001867 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 471856001868 ATP-binding site [chemical binding]; other site 471856001869 CoA-binding site [chemical binding]; other site 471856001870 Mg2+-binding site [ion binding]; other site 471856001871 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471856001872 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471856001873 glutaminase active site [active] 471856001874 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471856001875 dimer interface [polypeptide binding]; other site 471856001876 active site 471856001877 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471856001878 dimer interface [polypeptide binding]; other site 471856001879 active site 471856001880 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471856001881 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471856001882 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471856001883 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 471856001884 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471856001885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471856001886 alanine racemase; Reviewed; Region: alr; PRK00053 471856001887 active site 471856001888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471856001889 dimer interface [polypeptide binding]; other site 471856001890 substrate binding site [chemical binding]; other site 471856001891 catalytic residues [active] 471856001892 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 471856001893 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471856001894 Glycoprotease family; Region: Peptidase_M22; pfam00814 471856001895 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471856001896 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856001897 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471856001898 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471856001899 active site residue [active] 471856001900 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471856001901 active site residue [active] 471856001902 UGMP family protein; Validated; Region: PRK09604 471856001903 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471856001904 carboxylate-amine ligase; Provisional; Region: PRK13517 471856001905 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471856001906 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471856001907 oligomerisation interface [polypeptide binding]; other site 471856001908 mobile loop; other site 471856001909 roof hairpin; other site 471856001910 Transcription factor WhiB; Region: Whib; pfam02467 471856001911 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 471856001912 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471856001913 DNA binding residues [nucleotide binding] 471856001914 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471856001915 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471856001916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 471856001917 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471856001918 active site 471856001919 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 471856001920 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471856001921 active site 471856001922 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 471856001923 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471856001924 active site 471856001925 catalytic site [active] 471856001926 substrate binding site [chemical binding]; other site 471856001927 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471856001928 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471856001929 active site 471856001930 propionate/acetate kinase; Provisional; Region: PRK12379 471856001931 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 471856001932 phosphate acetyltransferase; Reviewed; Region: PRK05632 471856001933 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471856001934 DRTGG domain; Region: DRTGG; pfam07085 471856001935 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 471856001936 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471856001937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856001938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856001939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856001940 Walker A/P-loop; other site 471856001941 ATP binding site [chemical binding]; other site 471856001942 Q-loop/lid; other site 471856001943 ABC transporter signature motif; other site 471856001944 Walker B; other site 471856001945 D-loop; other site 471856001946 H-loop/switch region; other site 471856001947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856001948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856001949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856001950 Q-loop/lid; other site 471856001951 ABC transporter signature motif; other site 471856001952 Walker B; other site 471856001953 D-loop; other site 471856001954 H-loop/switch region; other site 471856001955 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 471856001956 GMP synthase; Reviewed; Region: guaA; PRK00074 471856001957 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471856001958 AMP/PPi binding site [chemical binding]; other site 471856001959 candidate oxyanion hole; other site 471856001960 catalytic triad [active] 471856001961 potential glutamine specificity residues [chemical binding]; other site 471856001962 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471856001963 ATP Binding subdomain [chemical binding]; other site 471856001964 Ligand Binding sites [chemical binding]; other site 471856001965 Dimerization subdomain; other site 471856001966 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 471856001967 PspC domain; Region: PspC; pfam04024 471856001968 Merozoite surface antigen 2c; Region: MSA-2c; pfam12238 471856001969 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471856001970 PspC domain; Region: PspC; pfam04024 471856001971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471856001972 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471856001973 ATP binding site [chemical binding]; other site 471856001974 Mg2+ binding site [ion binding]; other site 471856001975 G-X-G motif; other site 471856001976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856001977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856001978 active site 471856001979 phosphorylation site [posttranslational modification] 471856001980 intermolecular recognition site; other site 471856001981 dimerization interface [polypeptide binding]; other site 471856001982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856001983 DNA binding residues [nucleotide binding] 471856001984 dimerization interface [polypeptide binding]; other site 471856001985 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471856001986 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471856001987 putative active site [active] 471856001988 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 471856001989 active site 471856001990 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 471856001991 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 471856001992 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471856001993 active site 471856001994 SAM binding site [chemical binding]; other site 471856001995 homodimer interface [polypeptide binding]; other site 471856001996 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 471856001997 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 471856001998 CysD dimerization site [polypeptide binding]; other site 471856001999 G1 box; other site 471856002000 putative GEF interaction site [polypeptide binding]; other site 471856002001 GTP/Mg2+ binding site [chemical binding]; other site 471856002002 Switch I region; other site 471856002003 G2 box; other site 471856002004 G3 box; other site 471856002005 Switch II region; other site 471856002006 G4 box; other site 471856002007 G5 box; other site 471856002008 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 471856002009 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 471856002010 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 471856002011 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471856002012 Active Sites [active] 471856002013 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471856002014 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471856002015 Active Sites [active] 471856002016 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 471856002017 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471856002018 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471856002019 Protein of unknown function (DUF456); Region: DUF456; pfam04306 471856002020 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471856002021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856002022 DNA-binding site [nucleotide binding]; DNA binding site 471856002023 FCD domain; Region: FCD; pfam07729 471856002024 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 471856002025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471856002026 substrate binding pocket [chemical binding]; other site 471856002027 membrane-bound complex binding site; other site 471856002028 hinge residues; other site 471856002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856002030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856002031 dimer interface [polypeptide binding]; other site 471856002032 ABC-ATPase subunit interface; other site 471856002033 putative PBP binding loops; other site 471856002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856002035 dimer interface [polypeptide binding]; other site 471856002036 conserved gate region; other site 471856002037 putative PBP binding loops; other site 471856002038 ABC-ATPase subunit interface; other site 471856002039 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471856002040 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471856002041 Walker A/P-loop; other site 471856002042 ATP binding site [chemical binding]; other site 471856002043 Q-loop/lid; other site 471856002044 ABC transporter signature motif; other site 471856002045 Walker B; other site 471856002046 D-loop; other site 471856002047 H-loop/switch region; other site 471856002048 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471856002049 Part of AAA domain; Region: AAA_19; pfam13245 471856002050 Family description; Region: UvrD_C_2; pfam13538 471856002051 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471856002052 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471856002053 CoA-ligase; Region: Ligase_CoA; pfam00549 471856002054 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471856002055 CoA binding domain; Region: CoA_binding; smart00881 471856002056 CoA-ligase; Region: Ligase_CoA; pfam00549 471856002057 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 471856002058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471856002059 dimerization interface [polypeptide binding]; other site 471856002060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471856002061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856002062 dimer interface [polypeptide binding]; other site 471856002063 putative CheW interface [polypeptide binding]; other site 471856002064 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 471856002065 homodimer interface [polypeptide binding]; other site 471856002066 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 471856002067 active site pocket [active] 471856002068 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 471856002069 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471856002070 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471856002071 active site 471856002072 substrate binding site [chemical binding]; other site 471856002073 cosubstrate binding site; other site 471856002074 catalytic site [active] 471856002075 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471856002076 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471856002077 purine monophosphate binding site [chemical binding]; other site 471856002078 dimer interface [polypeptide binding]; other site 471856002079 putative catalytic residues [active] 471856002080 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 471856002081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471856002082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471856002083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471856002084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856002085 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471856002086 catalytic motif [active] 471856002087 Zn binding site [ion binding]; other site 471856002088 RibD C-terminal domain; Region: RibD_C; pfam01872 471856002089 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471856002090 Lumazine binding domain; Region: Lum_binding; pfam00677 471856002091 Lumazine binding domain; Region: Lum_binding; pfam00677 471856002092 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471856002093 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471856002094 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471856002095 dimerization interface [polypeptide binding]; other site 471856002096 active site 471856002097 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471856002098 homopentamer interface [polypeptide binding]; other site 471856002099 active site 471856002100 isocitrate dehydrogenase; Validated; Region: PRK08299 471856002101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856002102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856002103 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471856002104 Predicted membrane protein [Function unknown]; Region: COG1511 471856002105 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471856002106 malate dehydrogenase; Provisional; Region: PRK05442 471856002107 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471856002108 NAD(P) binding site [chemical binding]; other site 471856002109 dimer interface [polypeptide binding]; other site 471856002110 malate binding site [chemical binding]; other site 471856002111 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856002112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856002113 putative substrate translocation pore; other site 471856002114 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471856002115 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471856002116 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471856002117 putative active site [active] 471856002118 putative substrate binding site [chemical binding]; other site 471856002119 putative cosubstrate binding site; other site 471856002120 catalytic site [active] 471856002121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856002122 Coenzyme A binding pocket [chemical binding]; other site 471856002123 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471856002124 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471856002125 Walker A/P-loop; other site 471856002126 ATP binding site [chemical binding]; other site 471856002127 Q-loop/lid; other site 471856002128 ABC transporter signature motif; other site 471856002129 Walker B; other site 471856002130 D-loop; other site 471856002131 H-loop/switch region; other site 471856002132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856002133 dimerization interface [polypeptide binding]; other site 471856002134 putative DNA binding site [nucleotide binding]; other site 471856002135 putative Zn2+ binding site [ion binding]; other site 471856002136 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856002137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856002138 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471856002139 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471856002140 dimer interface [polypeptide binding]; other site 471856002141 active site 471856002142 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471856002143 folate binding site [chemical binding]; other site 471856002144 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471856002145 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471856002146 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471856002147 homodimer interface [polypeptide binding]; other site 471856002148 NADP binding site [chemical binding]; other site 471856002149 substrate binding site [chemical binding]; other site 471856002150 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 471856002151 generic binding surface II; other site 471856002152 generic binding surface I; other site 471856002153 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 471856002154 putative active site [active] 471856002155 putative catalytic site [active] 471856002156 putative Mg binding site IVb [ion binding]; other site 471856002157 putative phosphate binding site [ion binding]; other site 471856002158 putative DNA binding site [nucleotide binding]; other site 471856002159 putative Mg binding site IVa [ion binding]; other site 471856002160 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471856002161 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471856002162 active site 471856002163 metal binding site [ion binding]; metal-binding site 471856002164 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471856002165 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471856002166 putative catalytic site [active] 471856002167 putative metal binding site [ion binding]; other site 471856002168 putative phosphate binding site [ion binding]; other site 471856002169 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471856002170 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471856002171 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471856002172 Walker A motif; other site 471856002173 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 471856002174 MgtE intracellular N domain; Region: MgtE_N; smart00924 471856002175 FOG: CBS domain [General function prediction only]; Region: COG0517 471856002176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471856002177 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 471856002178 proline aminopeptidase P II; Provisional; Region: PRK10879 471856002179 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 471856002180 active site 471856002181 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471856002182 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 471856002183 active site 471856002184 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 471856002185 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 471856002186 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 471856002187 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471856002188 ATP binding site [chemical binding]; other site 471856002189 Mg++ binding site [ion binding]; other site 471856002190 motif III; other site 471856002191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856002192 nucleotide binding region [chemical binding]; other site 471856002193 ATP-binding site [chemical binding]; other site 471856002194 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 471856002195 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471856002196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856002197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856002198 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471856002199 Part of AAA domain; Region: AAA_19; pfam13245 471856002200 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471856002201 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471856002202 Part of AAA domain; Region: AAA_19; pfam13245 471856002203 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471856002204 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471856002205 Phosphotransferase enzyme family; Region: APH; pfam01636 471856002206 active site 471856002207 ATP binding site [chemical binding]; other site 471856002208 substrate binding site [chemical binding]; other site 471856002209 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471856002210 catalytic residues [active] 471856002211 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471856002212 Part of AAA domain; Region: AAA_19; pfam13245 471856002213 Family description; Region: UvrD_C_2; pfam13538 471856002214 HRDC domain; Region: HRDC; pfam00570 471856002215 Transcription factor WhiB; Region: Whib; pfam02467 471856002216 Protein of unknown function DUF45; Region: DUF45; cl00636 471856002217 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 471856002218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856002219 NAD(P) binding site [chemical binding]; other site 471856002220 active site 471856002221 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471856002222 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471856002223 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471856002224 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 471856002225 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471856002226 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 471856002227 active site 471856002228 catalytic residues [active] 471856002229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856002230 dimerization interface [polypeptide binding]; other site 471856002231 putative DNA binding site [nucleotide binding]; other site 471856002232 putative Zn2+ binding site [ion binding]; other site 471856002233 Predicted permeases [General function prediction only]; Region: COG0701 471856002234 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 471856002235 Cellulose binding domain; Region: CBM_2; pfam00553 471856002236 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471856002237 Cellulose binding domain; Region: CBM_2; pfam00553 471856002238 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471856002239 Cellulose binding domain; Region: CBM_2; pfam00553 471856002240 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 471856002241 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471856002242 Cellulose binding domain; Region: CBM_2; pfam00553 471856002243 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 471856002244 Cellulose binding domain; Region: CBM_2; pfam00553 471856002245 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856002246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856002247 DNA binding site [nucleotide binding] 471856002248 domain linker motif; other site 471856002249 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856002250 ligand binding site [chemical binding]; other site 471856002251 dimerization interface [polypeptide binding]; other site 471856002252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471856002253 Ligand Binding Site [chemical binding]; other site 471856002254 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 471856002255 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471856002256 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471856002257 putative active site [active] 471856002258 PhoH-like protein; Region: PhoH; pfam02562 471856002259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856002260 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471856002261 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471856002262 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 471856002263 active sites [active] 471856002264 tetramer interface [polypeptide binding]; other site 471856002265 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 471856002266 active site clefts [active] 471856002267 zinc binding site [ion binding]; other site 471856002268 dimer interface [polypeptide binding]; other site 471856002269 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471856002270 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471856002271 putative substrate binding site [chemical binding]; other site 471856002272 putative ATP binding site [chemical binding]; other site 471856002273 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471856002274 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471856002275 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471856002276 generic binding surface II; other site 471856002277 generic binding surface I; other site 471856002278 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 471856002279 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 471856002280 GTP-binding protein YchF; Reviewed; Region: PRK09601 471856002281 YchF GTPase; Region: YchF; cd01900 471856002282 G1 box; other site 471856002283 GTP/Mg2+ binding site [chemical binding]; other site 471856002284 Switch I region; other site 471856002285 G2 box; other site 471856002286 Switch II region; other site 471856002287 G3 box; other site 471856002288 G4 box; other site 471856002289 G5 box; other site 471856002290 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471856002291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856002292 S-adenosylmethionine binding site [chemical binding]; other site 471856002293 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 471856002294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856002295 non-specific DNA binding site [nucleotide binding]; other site 471856002296 salt bridge; other site 471856002297 sequence-specific DNA binding site [nucleotide binding]; other site 471856002298 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471856002299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471856002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856002301 non-specific DNA binding site [nucleotide binding]; other site 471856002302 salt bridge; other site 471856002303 sequence-specific DNA binding site [nucleotide binding]; other site 471856002304 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471856002305 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856002306 Walker A/P-loop; other site 471856002307 ATP binding site [chemical binding]; other site 471856002308 Q-loop/lid; other site 471856002309 ABC transporter signature motif; other site 471856002310 Walker B; other site 471856002311 D-loop; other site 471856002312 H-loop/switch region; other site 471856002313 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 471856002314 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 471856002315 Clp amino terminal domain; Region: Clp_N; pfam02861 471856002316 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471856002317 hydrophobic ligand binding site; other site 471856002318 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 471856002319 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 471856002320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856002321 sequence-specific DNA binding site [nucleotide binding]; other site 471856002322 salt bridge; other site 471856002323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471856002324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856002325 Coenzyme A binding pocket [chemical binding]; other site 471856002326 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 471856002327 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 471856002328 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471856002329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856002330 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471856002331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856002332 dimerization interface [polypeptide binding]; other site 471856002333 putative DNA binding site [nucleotide binding]; other site 471856002334 putative Zn2+ binding site [ion binding]; other site 471856002335 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471856002336 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471856002337 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 471856002338 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 471856002339 topology modulation protein; Reviewed; Region: PRK08118 471856002340 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 471856002341 active site 471856002342 Phospholipid methyltransferase; Region: PEMT; cl17370 471856002343 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471856002344 putative catalytic site [active] 471856002345 putative phosphate binding site [ion binding]; other site 471856002346 putative metal binding site [ion binding]; other site 471856002347 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471856002348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471856002349 putative NAD(P) binding site [chemical binding]; other site 471856002350 catalytic Zn binding site [ion binding]; other site 471856002351 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471856002352 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471856002353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471856002354 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471856002355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856002356 putative PBP binding loops; other site 471856002357 dimer interface [polypeptide binding]; other site 471856002358 ABC-ATPase subunit interface; other site 471856002359 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471856002360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471856002361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856002362 putative PBP binding loops; other site 471856002363 dimer interface [polypeptide binding]; other site 471856002364 ABC-ATPase subunit interface; other site 471856002365 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471856002366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856002367 Walker A/P-loop; other site 471856002368 ATP binding site [chemical binding]; other site 471856002369 Q-loop/lid; other site 471856002370 ABC transporter signature motif; other site 471856002371 Walker B; other site 471856002372 D-loop; other site 471856002373 H-loop/switch region; other site 471856002374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 471856002375 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856002376 Walker A/P-loop; other site 471856002377 ATP binding site [chemical binding]; other site 471856002378 Q-loop/lid; other site 471856002379 ABC transporter signature motif; other site 471856002380 Walker B; other site 471856002381 D-loop; other site 471856002382 H-loop/switch region; other site 471856002383 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471856002384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856002385 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856002386 Walker A/P-loop; other site 471856002387 ATP binding site [chemical binding]; other site 471856002388 Q-loop/lid; other site 471856002389 ABC transporter signature motif; other site 471856002390 Walker B; other site 471856002391 D-loop; other site 471856002392 H-loop/switch region; other site 471856002393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856002394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856002395 Walker A/P-loop; other site 471856002396 ATP binding site [chemical binding]; other site 471856002397 Q-loop/lid; other site 471856002398 ABC transporter signature motif; other site 471856002399 Walker B; other site 471856002400 D-loop; other site 471856002401 H-loop/switch region; other site 471856002402 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471856002403 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471856002404 G1 box; other site 471856002405 putative GEF interaction site [polypeptide binding]; other site 471856002406 GTP/Mg2+ binding site [chemical binding]; other site 471856002407 Switch I region; other site 471856002408 G2 box; other site 471856002409 G3 box; other site 471856002410 Switch II region; other site 471856002411 G4 box; other site 471856002412 G5 box; other site 471856002413 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471856002414 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471856002415 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471856002416 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471856002417 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471856002418 VanW like protein; Region: VanW; pfam04294 471856002419 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471856002420 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 471856002421 Prephenate dehydratase; Region: PDT; pfam00800 471856002422 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471856002423 putative L-Phe binding site [chemical binding]; other site 471856002424 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 471856002425 prephenate dehydrogenase; Validated; Region: PRK08507 471856002426 Ferredoxin [Energy production and conversion]; Region: COG1146 471856002427 4Fe-4S binding domain; Region: Fer4; pfam00037 471856002428 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 471856002429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856002430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856002431 homodimer interface [polypeptide binding]; other site 471856002432 catalytic residue [active] 471856002433 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471856002434 dimer interface [polypeptide binding]; other site 471856002435 Citrate synthase; Region: Citrate_synt; pfam00285 471856002436 active site 471856002437 citrylCoA binding site [chemical binding]; other site 471856002438 NADH binding [chemical binding]; other site 471856002439 cationic pore residues; other site 471856002440 oxalacetate/citrate binding site [chemical binding]; other site 471856002441 coenzyme A binding site [chemical binding]; other site 471856002442 catalytic triad [active] 471856002443 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 471856002444 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 471856002445 putative trimer interface [polypeptide binding]; other site 471856002446 putative CoA binding site [chemical binding]; other site 471856002447 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 471856002448 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471856002449 metal binding site [ion binding]; metal-binding site 471856002450 putative dimer interface [polypeptide binding]; other site 471856002451 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471856002452 dihydropteroate synthase; Region: DHPS; TIGR01496 471856002453 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471856002454 substrate binding pocket [chemical binding]; other site 471856002455 dimer interface [polypeptide binding]; other site 471856002456 inhibitor binding site; inhibition site 471856002457 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471856002458 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471856002459 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471856002460 interface (dimer of trimers) [polypeptide binding]; other site 471856002461 Substrate-binding/catalytic site; other site 471856002462 Zn-binding sites [ion binding]; other site 471856002463 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471856002464 Methyltransferase domain; Region: Methyltransf_24; pfam13578 471856002465 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471856002466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856002467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471856002468 DNA binding residues [nucleotide binding] 471856002469 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471856002470 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471856002471 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471856002472 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471856002473 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471856002474 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471856002475 active site 471856002476 HIGH motif; other site 471856002477 dimer interface [polypeptide binding]; other site 471856002478 KMSKS motif; other site 471856002479 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471856002480 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 471856002481 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 471856002482 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 471856002483 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471856002484 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 471856002485 L-aspartate oxidase; Provisional; Region: PRK06175 471856002486 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471856002487 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 471856002488 putative Iron-sulfur protein interface [polypeptide binding]; other site 471856002489 putative proximal heme binding site [chemical binding]; other site 471856002490 putative SdhC-like subunit interface [polypeptide binding]; other site 471856002491 putative distal heme binding site [chemical binding]; other site 471856002492 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 471856002493 putative Iron-sulfur protein interface [polypeptide binding]; other site 471856002494 putative proximal heme binding site [chemical binding]; other site 471856002495 putative SdhD-like interface [polypeptide binding]; other site 471856002496 putative distal heme binding site [chemical binding]; other site 471856002497 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 471856002498 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 471856002499 Substrate binding site; other site 471856002500 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471856002501 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471856002502 metal binding site [ion binding]; metal-binding site 471856002503 putative dimer interface [polypeptide binding]; other site 471856002504 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471856002505 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471856002506 ligand binding site [chemical binding]; other site 471856002507 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471856002508 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471856002509 Walker A/P-loop; other site 471856002510 ATP binding site [chemical binding]; other site 471856002511 Q-loop/lid; other site 471856002512 ABC transporter signature motif; other site 471856002513 Walker B; other site 471856002514 D-loop; other site 471856002515 H-loop/switch region; other site 471856002516 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471856002517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471856002518 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471856002519 TM-ABC transporter signature motif; other site 471856002520 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471856002521 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471856002522 TM-ABC transporter signature motif; other site 471856002523 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471856002524 active site 471856002525 catalytic motif [active] 471856002526 Zn binding site [ion binding]; other site 471856002527 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471856002528 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471856002529 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471856002530 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 471856002531 adenosine deaminase; Provisional; Region: PRK09358 471856002532 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471856002533 active site 471856002534 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471856002535 intersubunit interface [polypeptide binding]; other site 471856002536 active site 471856002537 catalytic residue [active] 471856002538 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471856002539 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471856002540 FAD binding pocket [chemical binding]; other site 471856002541 FAD binding motif [chemical binding]; other site 471856002542 phosphate binding motif [ion binding]; other site 471856002543 NAD binding pocket [chemical binding]; other site 471856002544 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471856002545 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471856002546 active site 471856002547 substrate binding site [chemical binding]; other site 471856002548 metal binding site [ion binding]; metal-binding site 471856002549 purine nucleoside phosphorylase; Provisional; Region: PRK08202 471856002550 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471856002551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856002552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856002553 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471856002554 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471856002555 nudix motif; other site 471856002556 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471856002557 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 471856002558 Ligand binding site; other site 471856002559 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471856002560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471856002561 active site 471856002562 NeuB family; Region: NeuB; pfam03102 471856002563 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 471856002564 ligand binding site; other site 471856002565 tetramer interface; other site 471856002566 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 471856002567 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471856002568 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471856002569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471856002570 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471856002571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471856002572 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471856002573 carboxyltransferase (CT) interaction site; other site 471856002574 biotinylation site [posttranslational modification]; other site 471856002575 Maf-like protein; Region: Maf; pfam02545 471856002576 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471856002577 active site 471856002578 dimer interface [polypeptide binding]; other site 471856002579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 471856002580 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 471856002581 putative active site [active] 471856002582 redox center [active] 471856002583 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471856002584 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471856002585 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 471856002586 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471856002587 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 471856002588 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471856002589 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471856002590 cyclase homology domain; Region: CHD; cd07302 471856002591 nucleotidyl binding site; other site 471856002592 metal binding site [ion binding]; metal-binding site 471856002593 dimer interface [polypeptide binding]; other site 471856002594 Uncharacterized conserved protein [Function unknown]; Region: COG2135 471856002595 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471856002596 active site 471856002597 catalytic residues [active] 471856002598 metal binding site [ion binding]; metal-binding site 471856002599 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471856002600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856002601 putative substrate translocation pore; other site 471856002602 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 471856002603 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471856002604 ATP binding site [chemical binding]; other site 471856002605 Walker A motif; other site 471856002606 hexamer interface [polypeptide binding]; other site 471856002607 Walker B motif; other site 471856002608 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471856002609 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471856002610 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471856002611 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471856002612 RF-1 domain; Region: RF-1; pfam00472 471856002613 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471856002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856002615 Walker A/P-loop; other site 471856002616 ATP binding site [chemical binding]; other site 471856002617 Q-loop/lid; other site 471856002618 ABC transporter signature motif; other site 471856002619 Walker B; other site 471856002620 D-loop; other site 471856002621 H-loop/switch region; other site 471856002622 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471856002623 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471856002624 Peptidase family M23; Region: Peptidase_M23; pfam01551 471856002625 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471856002626 SmpB-tmRNA interface; other site 471856002627 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471856002628 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 471856002629 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471856002630 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 471856002631 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 471856002632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856002633 RNA binding surface [nucleotide binding]; other site 471856002634 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471856002635 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471856002636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856002637 ATP binding site [chemical binding]; other site 471856002638 putative Mg++ binding site [ion binding]; other site 471856002639 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471856002640 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471856002641 active site 471856002642 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471856002643 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471856002644 glutamate racemase; Provisional; Region: PRK00865 471856002645 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471856002646 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471856002647 active site 471856002648 dimerization interface [polypeptide binding]; other site 471856002649 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 471856002650 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471856002651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856002652 Walker A/P-loop; other site 471856002653 ATP binding site [chemical binding]; other site 471856002654 Q-loop/lid; other site 471856002655 ABC transporter signature motif; other site 471856002656 Walker B; other site 471856002657 D-loop; other site 471856002658 H-loop/switch region; other site 471856002659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 471856002660 Walker A/P-loop; other site 471856002661 ATP binding site [chemical binding]; other site 471856002662 Q-loop/lid; other site 471856002663 ABC transporter signature motif; other site 471856002664 Walker B; other site 471856002665 D-loop; other site 471856002666 H-loop/switch region; other site 471856002667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471856002668 catalytic residues [active] 471856002669 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471856002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856002671 S-adenosylmethionine binding site [chemical binding]; other site 471856002672 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 471856002673 active site 471856002674 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471856002675 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471856002676 catalytic triad [active] 471856002677 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471856002678 oligomerisation interface [polypeptide binding]; other site 471856002679 mobile loop; other site 471856002680 roof hairpin; other site 471856002681 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 471856002682 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471856002683 dimerization interface [polypeptide binding]; other site 471856002684 DPS ferroxidase diiron center [ion binding]; other site 471856002685 ion pore; other site 471856002686 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471856002687 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856002688 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 471856002689 RNA/DNA hybrid binding site [nucleotide binding]; other site 471856002690 active site 471856002691 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471856002692 active site 471856002693 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471856002694 catalytic site [active] 471856002695 putative active site [active] 471856002696 putative substrate binding site [chemical binding]; other site 471856002697 dimer interface [polypeptide binding]; other site 471856002698 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471856002699 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471856002700 metal-binding site [ion binding] 471856002701 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471856002702 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856002703 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471856002704 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471856002705 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471856002706 putative NAD(P) binding site [chemical binding]; other site 471856002707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471856002708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856002709 S-adenosylmethionine binding site [chemical binding]; other site 471856002710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471856002711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471856002712 ligand binding site [chemical binding]; other site 471856002713 flexible hinge region; other site 471856002714 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471856002715 putative switch regulator; other site 471856002716 non-specific DNA interactions [nucleotide binding]; other site 471856002717 DNA binding site [nucleotide binding] 471856002718 sequence specific DNA binding site [nucleotide binding]; other site 471856002719 putative cAMP binding site [chemical binding]; other site 471856002720 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471856002721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856002722 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471856002723 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471856002724 putative homodimer interface [polypeptide binding]; other site 471856002725 putative homotetramer interface [polypeptide binding]; other site 471856002726 putative allosteric switch controlling residues; other site 471856002727 putative metal binding site [ion binding]; other site 471856002728 putative homodimer-homodimer interface [polypeptide binding]; other site 471856002729 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 471856002730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856002731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856002732 motif II; other site 471856002733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471856002734 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 471856002735 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471856002736 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471856002737 Predicted transcriptional regulators [Transcription]; Region: COG1733 471856002738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856002739 dimerization interface [polypeptide binding]; other site 471856002740 putative DNA binding site [nucleotide binding]; other site 471856002741 putative Zn2+ binding site [ion binding]; other site 471856002742 CrcB-like protein; Region: CRCB; cl09114 471856002743 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 471856002744 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471856002745 G1 box; other site 471856002746 GTP/Mg2+ binding site [chemical binding]; other site 471856002747 G2 box; other site 471856002748 Switch I region; other site 471856002749 G3 box; other site 471856002750 Switch II region; other site 471856002751 YfjP GTPase; Region: YfjP; cd11383 471856002752 G1 box; other site 471856002753 GTP/Mg2+ binding site [chemical binding]; other site 471856002754 Switch I region; other site 471856002755 G2 box; other site 471856002756 Switch II region; other site 471856002757 G3 box; other site 471856002758 G4 box; other site 471856002759 G5 box; other site 471856002760 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471856002761 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471856002762 dimer interface [polypeptide binding]; other site 471856002763 ssDNA binding site [nucleotide binding]; other site 471856002764 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471856002765 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471856002766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856002767 Cytochrome b562; Region: Cytochrom_B562; cl01546 471856002768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856002769 ABC transporter; Region: ABC_tran_2; pfam12848 471856002770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856002771 Dynamin family; Region: Dynamin_N; pfam00350 471856002772 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471856002773 G1 box; other site 471856002774 GTP/Mg2+ binding site [chemical binding]; other site 471856002775 G2 box; other site 471856002776 Switch I region; other site 471856002777 Dynamin family; Region: Dynamin_N; pfam00350 471856002778 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471856002779 G1 box; other site 471856002780 GTP/Mg2+ binding site [chemical binding]; other site 471856002781 G2 box; other site 471856002782 Switch I region; other site 471856002783 G3 box; other site 471856002784 Switch II region; other site 471856002785 G4 box; other site 471856002786 Protein of unknown function (DUF401); Region: DUF401; cl00830 471856002787 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471856002788 active site 471856002789 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471856002790 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471856002791 active site 471856002792 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471856002793 catalytic triad [active] 471856002794 dimer interface [polypeptide binding]; other site 471856002795 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471856002796 apolar tunnel; other site 471856002797 heme binding site [chemical binding]; other site 471856002798 dimerization interface [polypeptide binding]; other site 471856002799 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471856002800 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471856002801 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471856002802 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471856002803 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471856002804 active site turn [active] 471856002805 phosphorylation site [posttranslational modification] 471856002806 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 471856002807 HPr interaction site; other site 471856002808 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471856002809 active site 471856002810 phosphorylation site [posttranslational modification] 471856002811 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471856002812 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 471856002813 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471856002814 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471856002815 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471856002816 Zn binding site [ion binding]; other site 471856002817 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471856002818 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 471856002819 catalytic residues [active] 471856002820 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 471856002821 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 471856002822 active site 471856002823 Zn binding site [ion binding]; other site 471856002824 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 471856002825 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471856002826 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 471856002827 putative DNA binding site [nucleotide binding]; other site 471856002828 catalytic residue [active] 471856002829 putative H2TH interface [polypeptide binding]; other site 471856002830 putative catalytic residues [active] 471856002831 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471856002832 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471856002833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 471856002834 hypothetical protein; Provisional; Region: PRK01346 471856002835 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471856002836 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471856002837 serine O-acetyltransferase; Region: cysE; TIGR01172 471856002838 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471856002839 trimer interface [polypeptide binding]; other site 471856002840 active site 471856002841 substrate binding site [chemical binding]; other site 471856002842 CoA binding site [chemical binding]; other site 471856002843 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471856002844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471856002845 dimer interface [polypeptide binding]; other site 471856002846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856002847 catalytic residue [active] 471856002848 trigger factor; Provisional; Region: tig; PRK01490 471856002849 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471856002850 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471856002851 Clp protease; Region: CLP_protease; pfam00574 471856002852 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471856002853 oligomer interface [polypeptide binding]; other site 471856002854 active site residues [active] 471856002855 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471856002856 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471856002857 oligomer interface [polypeptide binding]; other site 471856002858 active site residues [active] 471856002859 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471856002860 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471856002861 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471856002862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856002863 Walker A motif; other site 471856002864 ATP binding site [chemical binding]; other site 471856002865 Walker B motif; other site 471856002866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471856002867 chorismate mutase; Provisional; Region: PRK09239 471856002868 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471856002869 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471856002870 Walker A/P-loop; other site 471856002871 ATP binding site [chemical binding]; other site 471856002872 Q-loop/lid; other site 471856002873 ABC transporter signature motif; other site 471856002874 Walker B; other site 471856002875 D-loop; other site 471856002876 H-loop/switch region; other site 471856002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856002878 dimer interface [polypeptide binding]; other site 471856002879 conserved gate region; other site 471856002880 putative PBP binding loops; other site 471856002881 ABC-ATPase subunit interface; other site 471856002882 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471856002883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471856002884 substrate binding pocket [chemical binding]; other site 471856002885 membrane-bound complex binding site; other site 471856002886 hinge residues; other site 471856002887 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471856002888 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471856002889 acyl-activating enzyme (AAE) consensus motif; other site 471856002890 putative AMP binding site [chemical binding]; other site 471856002891 putative active site [active] 471856002892 putative CoA binding site [chemical binding]; other site 471856002893 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 471856002894 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856002895 active site 471856002896 HIGH motif; other site 471856002897 nucleotide binding site [chemical binding]; other site 471856002898 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856002899 active site 471856002900 KMSKS motif; other site 471856002901 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471856002902 tRNA binding surface [nucleotide binding]; other site 471856002903 anticodon binding site; other site 471856002904 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 471856002905 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471856002906 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 471856002907 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471856002908 Walker A/P-loop; other site 471856002909 ATP binding site [chemical binding]; other site 471856002910 Q-loop/lid; other site 471856002911 ABC transporter signature motif; other site 471856002912 Walker B; other site 471856002913 D-loop; other site 471856002914 H-loop/switch region; other site 471856002915 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471856002916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856002917 ABC-ATPase subunit interface; other site 471856002918 dimer interface [polypeptide binding]; other site 471856002919 putative PBP binding regions; other site 471856002920 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471856002921 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 471856002922 intersubunit interface [polypeptide binding]; other site 471856002923 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471856002924 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471856002925 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 471856002926 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471856002927 HIGH motif; other site 471856002928 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471856002929 active site 471856002930 KMSKS motif; other site 471856002931 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471856002932 tRNA binding surface [nucleotide binding]; other site 471856002933 anticodon binding site; other site 471856002934 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471856002935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471856002936 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471856002937 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 471856002938 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 471856002939 DAK2 domain; Region: Dak2; cl03685 471856002940 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 471856002941 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471856002942 dimerization domain swap beta strand [polypeptide binding]; other site 471856002943 regulatory protein interface [polypeptide binding]; other site 471856002944 active site 471856002945 regulatory phosphorylation site [posttranslational modification]; other site 471856002946 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 471856002947 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 471856002948 active site 471856002949 multimer interface [polypeptide binding]; other site 471856002950 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471856002951 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471856002952 Walker A/P-loop; other site 471856002953 ATP binding site [chemical binding]; other site 471856002954 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 471856002955 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471856002956 ABC transporter signature motif; other site 471856002957 Walker B; other site 471856002958 D-loop; other site 471856002959 H-loop/switch region; other site 471856002960 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471856002961 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471856002962 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471856002963 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 471856002964 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 471856002965 Nitrogen regulatory protein P-II; Region: P-II; smart00938 471856002966 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471856002967 metal binding triad; other site 471856002968 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471856002969 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 471856002970 signal recognition particle protein; Provisional; Region: PRK10867 471856002971 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471856002972 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471856002973 P loop; other site 471856002974 GTP binding site [chemical binding]; other site 471856002975 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471856002976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471856002977 active site 471856002978 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 471856002979 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 471856002980 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471856002981 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471856002982 RimM N-terminal domain; Region: RimM; pfam01782 471856002983 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471856002984 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471856002985 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471856002986 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471856002987 Catalytic site [active] 471856002988 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471856002989 RNA/DNA hybrid binding site [nucleotide binding]; other site 471856002990 active site 471856002991 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471856002992 hypothetical protein; Reviewed; Region: PRK12497 471856002993 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471856002994 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471856002995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856002996 Walker A motif; other site 471856002997 ATP binding site [chemical binding]; other site 471856002998 Walker B motif; other site 471856002999 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471856003000 catalytic motif [active] 471856003001 Zn binding site [ion binding]; other site 471856003002 Predicted ATPase [General function prediction only]; Region: COG5293 471856003003 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 471856003004 AAA domain; Region: AAA_30; pfam13604 471856003005 Family description; Region: UvrD_C_2; pfam13538 471856003006 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471856003007 DNA protecting protein DprA; Region: dprA; TIGR00732 471856003008 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471856003009 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856003010 active site 471856003011 DNA binding site [nucleotide binding] 471856003012 Int/Topo IB signature motif; other site 471856003013 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 471856003014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856003015 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471856003016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471856003017 DNA binding residues [nucleotide binding] 471856003018 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471856003019 Peptidase family M23; Region: Peptidase_M23; pfam01551 471856003020 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471856003021 rRNA interaction site [nucleotide binding]; other site 471856003022 S8 interaction site; other site 471856003023 putative laminin-1 binding site; other site 471856003024 elongation factor Ts; Provisional; Region: tsf; PRK09377 471856003025 UBA/TS-N domain; Region: UBA; pfam00627 471856003026 Elongation factor TS; Region: EF_TS; pfam00889 471856003027 Elongation factor TS; Region: EF_TS; pfam00889 471856003028 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471856003029 putative nucleotide binding site [chemical binding]; other site 471856003030 uridine monophosphate binding site [chemical binding]; other site 471856003031 homohexameric interface [polypeptide binding]; other site 471856003032 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471856003033 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471856003034 hinge region; other site 471856003035 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471856003036 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471856003037 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471856003038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856003039 FeS/SAM binding site; other site 471856003040 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471856003041 DivIVA domain; Region: DivI1A_domain; TIGR03544 471856003042 DivIVA domain; Region: DivI1A_domain; TIGR03544 471856003043 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471856003044 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471856003045 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471856003046 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471856003047 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471856003048 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471856003049 active site 471856003050 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471856003051 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471856003052 putative substrate binding region [chemical binding]; other site 471856003053 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471856003054 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471856003055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471856003056 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 471856003057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856003058 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471856003059 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471856003060 dimer interface [polypeptide binding]; other site 471856003061 motif 1; other site 471856003062 active site 471856003063 motif 2; other site 471856003064 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471856003065 putative deacylase active site [active] 471856003066 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471856003067 active site 471856003068 motif 3; other site 471856003069 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471856003070 anticodon binding site; other site 471856003071 Sm and related proteins; Region: Sm_like; cl00259 471856003072 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471856003073 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471856003074 putative oligomer interface [polypeptide binding]; other site 471856003075 putative RNA binding site [nucleotide binding]; other site 471856003076 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471856003077 NusA N-terminal domain; Region: NusA_N; pfam08529 471856003078 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471856003079 RNA binding site [nucleotide binding]; other site 471856003080 homodimer interface [polypeptide binding]; other site 471856003081 NusA-like KH domain; Region: KH_5; pfam13184 471856003082 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471856003083 G-X-X-G motif; other site 471856003084 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471856003085 translation initiation factor IF-2; Region: IF-2; TIGR00487 471856003086 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471856003087 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471856003088 G1 box; other site 471856003089 putative GEF interaction site [polypeptide binding]; other site 471856003090 GTP/Mg2+ binding site [chemical binding]; other site 471856003091 Switch I region; other site 471856003092 G2 box; other site 471856003093 G3 box; other site 471856003094 Switch II region; other site 471856003095 G4 box; other site 471856003096 G5 box; other site 471856003097 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471856003098 Translation-initiation factor 2; Region: IF-2; pfam11987 471856003099 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471856003100 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471856003101 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471856003102 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471856003103 RNA binding site [nucleotide binding]; other site 471856003104 active site 471856003105 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 471856003106 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471856003107 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471856003108 active site 471856003109 Riboflavin kinase; Region: Flavokinase; pfam01687 471856003110 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471856003111 amidase catalytic site [active] 471856003112 Zn binding residues [ion binding]; other site 471856003113 substrate binding site [chemical binding]; other site 471856003114 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471856003115 16S/18S rRNA binding site [nucleotide binding]; other site 471856003116 S13e-L30e interaction site [polypeptide binding]; other site 471856003117 25S rRNA binding site [nucleotide binding]; other site 471856003118 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471856003119 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 471856003120 oligomer interface [polypeptide binding]; other site 471856003121 RNA binding site [nucleotide binding]; other site 471856003122 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471856003123 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471856003124 RNase E interface [polypeptide binding]; other site 471856003125 trimer interface [polypeptide binding]; other site 471856003126 active site 471856003127 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471856003128 putative nucleic acid binding region [nucleotide binding]; other site 471856003129 G-X-X-G motif; other site 471856003130 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471856003131 RNA binding site [nucleotide binding]; other site 471856003132 domain interface; other site 471856003133 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471856003134 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471856003135 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471856003136 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471856003137 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471856003138 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471856003139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856003140 Coenzyme A binding pocket [chemical binding]; other site 471856003141 thymidylate synthase; Reviewed; Region: thyA; PRK01827 471856003142 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471856003143 dimerization interface [polypeptide binding]; other site 471856003144 active site 471856003145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471856003146 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471856003147 folate binding site [chemical binding]; other site 471856003148 NADP+ binding site [chemical binding]; other site 471856003149 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471856003150 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471856003151 dimer interface [polypeptide binding]; other site 471856003152 active site 471856003153 catalytic residue [active] 471856003154 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471856003155 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471856003156 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471856003157 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471856003158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471856003159 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 471856003160 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471856003161 Competence-damaged protein; Region: CinA; pfam02464 471856003162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856003163 non-specific DNA binding site [nucleotide binding]; other site 471856003164 salt bridge; other site 471856003165 sequence-specific DNA binding site [nucleotide binding]; other site 471856003166 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471856003167 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 471856003168 putative DNA binding site [nucleotide binding]; other site 471856003169 catalytic residue [active] 471856003170 putative H2TH interface [polypeptide binding]; other site 471856003171 putative catalytic residues [active] 471856003172 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471856003173 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471856003174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856003175 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 471856003176 ATP binding site [chemical binding]; other site 471856003177 putative Mg++ binding site [ion binding]; other site 471856003178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856003179 nucleotide binding region [chemical binding]; other site 471856003180 ATP-binding site [chemical binding]; other site 471856003181 DEAD/H associated; Region: DEAD_assoc; pfam08494 471856003182 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471856003183 recombinase A; Provisional; Region: recA; PRK09354 471856003184 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471856003185 hexamer interface [polypeptide binding]; other site 471856003186 Walker A motif; other site 471856003187 ATP binding site [chemical binding]; other site 471856003188 Walker B motif; other site 471856003189 RecX family; Region: RecX; cl00936 471856003190 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 471856003191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471856003192 Zn2+ binding site [ion binding]; other site 471856003193 Mg2+ binding site [ion binding]; other site 471856003194 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471856003195 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471856003196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856003197 FeS/SAM binding site; other site 471856003198 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 471856003199 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 471856003200 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471856003201 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471856003202 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471856003203 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471856003204 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471856003205 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 471856003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856003207 S-adenosylmethionine binding site [chemical binding]; other site 471856003208 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471856003209 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471856003210 HflX GTPase family; Region: HflX; cd01878 471856003211 G1 box; other site 471856003212 GTP/Mg2+ binding site [chemical binding]; other site 471856003213 Switch I region; other site 471856003214 G2 box; other site 471856003215 G3 box; other site 471856003216 Switch II region; other site 471856003217 G4 box; other site 471856003218 G5 box; other site 471856003219 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471856003220 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471856003221 DEAD_2; Region: DEAD_2; pfam06733 471856003222 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471856003223 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 471856003224 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 471856003225 NAD(P) binding site [chemical binding]; other site 471856003226 LDH/MDH dimer interface [polypeptide binding]; other site 471856003227 substrate binding site [chemical binding]; other site 471856003228 LexA repressor; Validated; Region: PRK00215 471856003229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856003230 putative DNA binding site [nucleotide binding]; other site 471856003231 putative Zn2+ binding site [ion binding]; other site 471856003232 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471856003233 Catalytic site [active] 471856003234 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471856003235 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471856003236 ATP cone domain; Region: ATP-cone; pfam03477 471856003237 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471856003238 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471856003239 active site 471856003240 catalytic tetrad [active] 471856003241 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 471856003242 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 471856003243 ligand binding site [chemical binding]; other site 471856003244 NAD binding site [chemical binding]; other site 471856003245 tetramer interface [polypeptide binding]; other site 471856003246 catalytic site [active] 471856003247 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 471856003248 L-serine binding site [chemical binding]; other site 471856003249 ACT domain interface; other site 471856003250 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471856003251 Part of AAA domain; Region: AAA_19; pfam13245 471856003252 Family description; Region: UvrD_C_2; pfam13538 471856003253 PAC2 family; Region: PAC2; pfam09754 471856003254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471856003255 DNA polymerase IV; Validated; Region: PRK03858 471856003256 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471856003257 active site 471856003258 DNA binding site [nucleotide binding] 471856003259 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471856003260 MraZ protein; Region: MraZ; pfam02381 471856003261 cell division protein MraZ; Reviewed; Region: PRK00326 471856003262 MraZ protein; Region: MraZ; pfam02381 471856003263 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471856003264 MraW methylase family; Region: Methyltransf_5; cl17771 471856003265 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471856003266 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471856003267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471856003268 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471856003269 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471856003270 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471856003271 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471856003272 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471856003273 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471856003274 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471856003275 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471856003276 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471856003277 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471856003278 Mg++ binding site [ion binding]; other site 471856003279 putative catalytic motif [active] 471856003280 putative substrate binding site [chemical binding]; other site 471856003281 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471856003282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471856003283 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 471856003284 cell division protein FtsW; Region: ftsW; TIGR02614 471856003285 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471856003286 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471856003287 active site 471856003288 homodimer interface [polypeptide binding]; other site 471856003289 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471856003290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471856003291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471856003292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471856003293 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471856003294 Cell division protein FtsQ; Region: FtsQ; pfam03799 471856003295 cell division protein FtsZ; Validated; Region: PRK09330 471856003296 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471856003297 nucleotide binding site [chemical binding]; other site 471856003298 SulA interaction site; other site 471856003299 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471856003300 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471856003301 Protein of unknown function (DUF552); Region: DUF552; pfam04472 471856003302 DivIVA protein; Region: DivIVA; pfam05103 471856003303 DivIVA domain; Region: DivI1A_domain; TIGR03544 471856003304 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 471856003305 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 471856003306 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 471856003307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856003308 RNA binding surface [nucleotide binding]; other site 471856003309 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471856003310 active site 471856003311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856003312 Coenzyme A binding pocket [chemical binding]; other site 471856003313 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471856003314 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471856003315 active site 471856003316 PHP Thumb interface [polypeptide binding]; other site 471856003317 metal binding site [ion binding]; metal-binding site 471856003318 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471856003319 generic binding surface II; other site 471856003320 generic binding surface I; other site 471856003321 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471856003322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856003323 RNA binding surface [nucleotide binding]; other site 471856003324 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 471856003325 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471856003326 NAD binding site [chemical binding]; other site 471856003327 dimerization interface [polypeptide binding]; other site 471856003328 product binding site; other site 471856003329 substrate binding site [chemical binding]; other site 471856003330 zinc binding site [ion binding]; other site 471856003331 catalytic residues [active] 471856003332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856003333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856003334 DNA binding site [nucleotide binding] 471856003335 domain linker motif; other site 471856003336 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856003337 ligand binding site [chemical binding]; other site 471856003338 dimerization interface [polypeptide binding]; other site 471856003339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856003340 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856003341 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471856003342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856003343 ATP binding site [chemical binding]; other site 471856003344 putative Mg++ binding site [ion binding]; other site 471856003345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856003346 nucleotide binding region [chemical binding]; other site 471856003347 ATP-binding site [chemical binding]; other site 471856003348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856003349 active site 471856003350 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 471856003351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856003352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856003353 homodimer interface [polypeptide binding]; other site 471856003354 catalytic residue [active] 471856003355 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471856003356 putative active site pocket [active] 471856003357 4-fold oligomerization interface [polypeptide binding]; other site 471856003358 metal binding residues [ion binding]; metal-binding site 471856003359 3-fold/trimer interface [polypeptide binding]; other site 471856003360 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471856003361 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471856003362 putative active site [active] 471856003363 oxyanion strand; other site 471856003364 catalytic triad [active] 471856003365 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471856003366 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471856003367 catalytic residues [active] 471856003368 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471856003369 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471856003370 hypothetical protein; Provisional; Region: PRK11281 471856003371 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471856003372 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 471856003373 heme binding pocket [chemical binding]; other site 471856003374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471856003375 metal binding site 2 [ion binding]; metal-binding site 471856003376 putative DNA binding helix; other site 471856003377 metal binding site 1 [ion binding]; metal-binding site 471856003378 dimer interface [polypeptide binding]; other site 471856003379 structural Zn2+ binding site [ion binding]; other site 471856003380 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471856003381 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471856003382 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471856003383 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471856003384 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471856003385 23S rRNA binding site [nucleotide binding]; other site 471856003386 L21 binding site [polypeptide binding]; other site 471856003387 L13 binding site [polypeptide binding]; other site 471856003388 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471856003389 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471856003390 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471856003391 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471856003392 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471856003393 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471856003394 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471856003395 dimer interface [polypeptide binding]; other site 471856003396 motif 1; other site 471856003397 active site 471856003398 motif 2; other site 471856003399 motif 3; other site 471856003400 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471856003401 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471856003402 putative tRNA-binding site [nucleotide binding]; other site 471856003403 B3/4 domain; Region: B3_4; pfam03483 471856003404 tRNA synthetase B5 domain; Region: B5; smart00874 471856003405 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471856003406 dimer interface [polypeptide binding]; other site 471856003407 motif 1; other site 471856003408 motif 3; other site 471856003409 motif 2; other site 471856003410 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471856003411 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471856003412 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471856003413 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471856003414 heterotetramer interface [polypeptide binding]; other site 471856003415 active site pocket [active] 471856003416 cleavage site 471856003417 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 471856003418 feedback inhibition sensing region; other site 471856003419 homohexameric interface [polypeptide binding]; other site 471856003420 nucleotide binding site [chemical binding]; other site 471856003421 N-acetyl-L-glutamate binding site [chemical binding]; other site 471856003422 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471856003423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471856003424 inhibitor-cofactor binding pocket; inhibition site 471856003425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856003426 catalytic residue [active] 471856003427 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471856003428 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471856003429 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471856003430 arginine repressor; Provisional; Region: PRK03341 471856003431 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471856003432 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471856003433 argininosuccinate synthase; Provisional; Region: PRK13820 471856003434 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471856003435 ANP binding site [chemical binding]; other site 471856003436 Substrate Binding Site II [chemical binding]; other site 471856003437 Substrate Binding Site I [chemical binding]; other site 471856003438 argininosuccinate lyase; Provisional; Region: PRK00855 471856003439 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471856003440 active sites [active] 471856003441 tetramer interface [polypeptide binding]; other site 471856003442 hypothetical protein; Provisional; Region: PRK06547 471856003443 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471856003444 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471856003445 active site 471856003446 HIGH motif; other site 471856003447 dimer interface [polypeptide binding]; other site 471856003448 KMSKS motif; other site 471856003449 S4 RNA-binding domain; Region: S4; smart00363 471856003450 RNA binding surface [nucleotide binding]; other site 471856003451 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471856003452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856003453 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 471856003454 active site 471856003455 motif I; other site 471856003456 motif II; other site 471856003457 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471856003458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856003459 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471856003460 RNA binding surface [nucleotide binding]; other site 471856003461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856003462 S-adenosylmethionine binding site [chemical binding]; other site 471856003463 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 471856003464 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471856003465 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471856003466 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471856003467 Walker A/P-loop; other site 471856003468 ATP binding site [chemical binding]; other site 471856003469 Q-loop/lid; other site 471856003470 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471856003471 ABC transporter signature motif; other site 471856003472 Walker B; other site 471856003473 D-loop; other site 471856003474 H-loop/switch region; other site 471856003475 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 471856003476 Thiamine pyrophosphokinase; Region: TPK; cl08415 471856003477 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 471856003478 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 471856003479 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471856003480 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 471856003481 putative ADP-binding pocket [chemical binding]; other site 471856003482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471856003483 CTP synthetase; Validated; Region: pyrG; PRK05380 471856003484 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471856003485 Catalytic site [active] 471856003486 active site 471856003487 UTP binding site [chemical binding]; other site 471856003488 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471856003489 active site 471856003490 putative oxyanion hole; other site 471856003491 catalytic triad [active] 471856003492 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471856003493 dimer interface [polypeptide binding]; other site 471856003494 ADP-ribose binding site [chemical binding]; other site 471856003495 active site 471856003496 nudix motif; other site 471856003497 metal binding site [ion binding]; metal-binding site 471856003498 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 471856003499 Cellulose binding domain; Region: CBM_2; pfam00553 471856003500 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471856003501 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471856003502 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471856003503 Predicted membrane protein [Function unknown]; Region: COG2364 471856003504 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471856003505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471856003506 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856003507 Walker A/P-loop; other site 471856003508 ATP binding site [chemical binding]; other site 471856003509 Q-loop/lid; other site 471856003510 ABC transporter signature motif; other site 471856003511 Walker B; other site 471856003512 D-loop; other site 471856003513 H-loop/switch region; other site 471856003514 Predicted transcriptional regulator [Transcription]; Region: COG2345 471856003515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856003516 putative DNA binding site [nucleotide binding]; other site 471856003517 putative Zn2+ binding site [ion binding]; other site 471856003518 FeS assembly protein SufB; Region: sufB; TIGR01980 471856003519 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471856003520 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471856003521 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 471856003522 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 471856003523 [2Fe-2S] cluster binding site [ion binding]; other site 471856003524 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 471856003525 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471856003526 Walker A/P-loop; other site 471856003527 ATP binding site [chemical binding]; other site 471856003528 Q-loop/lid; other site 471856003529 ABC transporter signature motif; other site 471856003530 Walker B; other site 471856003531 D-loop; other site 471856003532 H-loop/switch region; other site 471856003533 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471856003534 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471856003535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856003536 catalytic residue [active] 471856003537 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471856003538 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471856003539 trimerization site [polypeptide binding]; other site 471856003540 active site 471856003541 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471856003542 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471856003543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856003544 putative DNA binding site [nucleotide binding]; other site 471856003545 putative Zn2+ binding site [ion binding]; other site 471856003546 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 471856003547 LabA_like proteins; Region: LabA_like; cd06167 471856003548 putative metal binding site [ion binding]; other site 471856003549 Uncharacterized conserved protein [Function unknown]; Region: COG1432 471856003550 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 471856003551 Aspartase; Region: Aspartase; cd01357 471856003552 active sites [active] 471856003553 tetramer interface [polypeptide binding]; other site 471856003554 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471856003555 L-asparaginase II; Region: Asparaginase_II; pfam06089 471856003556 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 471856003557 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471856003558 Cobalt transport protein; Region: CbiQ; cl00463 471856003559 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471856003560 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856003561 Walker A/P-loop; other site 471856003562 ATP binding site [chemical binding]; other site 471856003563 Q-loop/lid; other site 471856003564 ABC transporter signature motif; other site 471856003565 Walker B; other site 471856003566 D-loop; other site 471856003567 H-loop/switch region; other site 471856003568 BioY family; Region: BioY; pfam02632 471856003569 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471856003570 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856003571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856003572 ABC transporter; Region: ABC_tran_2; pfam12848 471856003573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856003574 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471856003575 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471856003576 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471856003577 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471856003578 NAD(P) binding site [chemical binding]; other site 471856003579 homotetramer interface [polypeptide binding]; other site 471856003580 homodimer interface [polypeptide binding]; other site 471856003581 active site 471856003582 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 471856003583 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471856003584 NAD binding site [chemical binding]; other site 471856003585 homotetramer interface [polypeptide binding]; other site 471856003586 homodimer interface [polypeptide binding]; other site 471856003587 substrate binding site [chemical binding]; other site 471856003588 active site 471856003589 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471856003590 catalytic core [active] 471856003591 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471856003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856003593 motif II; other site 471856003594 Protein of unknown function (DUF461); Region: DUF461; pfam04314 471856003595 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 471856003596 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 471856003597 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 471856003598 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471856003599 ligand binding site; other site 471856003600 oligomer interface; other site 471856003601 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471856003602 dimer interface [polypeptide binding]; other site 471856003603 N-terminal domain interface [polypeptide binding]; other site 471856003604 sulfate 1 binding site; other site 471856003605 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 471856003606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471856003607 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471856003608 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471856003609 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471856003610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856003611 Walker A/P-loop; other site 471856003612 ATP binding site [chemical binding]; other site 471856003613 Q-loop/lid; other site 471856003614 ABC transporter signature motif; other site 471856003615 Walker B; other site 471856003616 D-loop; other site 471856003617 H-loop/switch region; other site 471856003618 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 471856003619 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471856003620 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471856003621 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471856003622 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471856003623 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 471856003624 substrate binding site [chemical binding]; other site 471856003625 multimerization interface [polypeptide binding]; other site 471856003626 ATP binding site [chemical binding]; other site 471856003627 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471856003628 thiamine phosphate binding site [chemical binding]; other site 471856003629 active site 471856003630 pyrophosphate binding site [ion binding]; other site 471856003631 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 471856003632 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471856003633 dimer interface [polypeptide binding]; other site 471856003634 substrate binding site [chemical binding]; other site 471856003635 ATP binding site [chemical binding]; other site 471856003636 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 471856003637 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 471856003638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856003639 Coenzyme A binding pocket [chemical binding]; other site 471856003640 DNA Polymerase Y-family; Region: PolY_like; cd03468 471856003641 active site 471856003642 DNA binding site [nucleotide binding] 471856003643 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 471856003644 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 471856003645 active site 471856003646 PHP Thumb interface [polypeptide binding]; other site 471856003647 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471856003648 generic binding surface II; other site 471856003649 generic binding surface I; other site 471856003650 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471856003651 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471856003652 inhibitor site; inhibition site 471856003653 active site 471856003654 dimer interface [polypeptide binding]; other site 471856003655 catalytic residue [active] 471856003656 Beta-lactamase; Region: Beta-lactamase; pfam00144 471856003657 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471856003658 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856003659 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856003660 nucleotide binding site [chemical binding]; other site 471856003661 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 471856003662 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 471856003663 active site 471856003664 Zn binding site [ion binding]; other site 471856003665 hypothetical protein; Provisional; Region: PRK07906 471856003666 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471856003667 putative metal binding site [ion binding]; other site 471856003668 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 471856003669 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856003670 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 471856003671 active site 471856003672 HIGH motif; other site 471856003673 nucleotide binding site [chemical binding]; other site 471856003674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856003675 active site 471856003676 KMSKS motif; other site 471856003677 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 471856003678 putative tRNA binding surface [nucleotide binding]; other site 471856003679 PAC2 family; Region: PAC2; pfam09754 471856003680 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 471856003681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856003682 motif II; other site 471856003683 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471856003684 Peptidase family M50; Region: Peptidase_M50; pfam02163 471856003685 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 471856003686 active site 471856003687 putative substrate binding region [chemical binding]; other site 471856003688 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471856003689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856003690 S-adenosylmethionine binding site [chemical binding]; other site 471856003691 proteasome ATPase; Region: pup_AAA; TIGR03689 471856003692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856003693 Walker A motif; other site 471856003694 ATP binding site [chemical binding]; other site 471856003695 Walker B motif; other site 471856003696 arginine finger; other site 471856003697 Pup-ligase protein; Region: Pup_ligase; cl15463 471856003698 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 471856003699 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 471856003700 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471856003701 active site 471856003702 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471856003703 active site 471856003704 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 471856003705 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471856003706 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471856003707 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471856003708 substrate binding site [chemical binding]; other site 471856003709 glutamase interaction surface [polypeptide binding]; other site 471856003710 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856003712 Walker A/P-loop; other site 471856003713 ATP binding site [chemical binding]; other site 471856003714 Q-loop/lid; other site 471856003715 ABC transporter signature motif; other site 471856003716 Walker B; other site 471856003717 D-loop; other site 471856003718 H-loop/switch region; other site 471856003719 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 471856003720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856003721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856003722 Walker A/P-loop; other site 471856003723 ATP binding site [chemical binding]; other site 471856003724 Q-loop/lid; other site 471856003725 ABC transporter signature motif; other site 471856003726 Walker B; other site 471856003727 D-loop; other site 471856003728 H-loop/switch region; other site 471856003729 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 471856003730 anthranilate synthase component I; Provisional; Region: PRK13571 471856003731 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471856003732 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471856003733 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471856003734 active site 471856003735 ribulose/triose binding site [chemical binding]; other site 471856003736 phosphate binding site [ion binding]; other site 471856003737 substrate (anthranilate) binding pocket [chemical binding]; other site 471856003738 product (indole) binding pocket [chemical binding]; other site 471856003739 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471856003740 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471856003741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856003742 catalytic residue [active] 471856003743 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 471856003744 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471856003745 substrate binding site [chemical binding]; other site 471856003746 active site 471856003747 catalytic residues [active] 471856003748 heterodimer interface [polypeptide binding]; other site 471856003749 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471856003750 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471856003751 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471856003752 active site 471856003753 dimer interface [polypeptide binding]; other site 471856003754 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471856003755 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471856003756 active site 471856003757 FMN binding site [chemical binding]; other site 471856003758 substrate binding site [chemical binding]; other site 471856003759 3Fe-4S cluster binding site [ion binding]; other site 471856003760 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471856003761 domain interface; other site 471856003762 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471856003763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471856003764 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 471856003765 pyruvate kinase; Provisional; Region: PRK06247 471856003766 domain interfaces; other site 471856003767 active site 471856003768 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471856003769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856003770 active site 471856003771 phosphorylation site [posttranslational modification] 471856003772 intermolecular recognition site; other site 471856003773 dimerization interface [polypeptide binding]; other site 471856003774 ANTAR domain; Region: ANTAR; pfam03861 471856003775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856003776 Coenzyme A binding pocket [chemical binding]; other site 471856003777 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471856003778 CoenzymeA binding site [chemical binding]; other site 471856003779 subunit interaction site [polypeptide binding]; other site 471856003780 PHB binding site; other site 471856003781 DNA polymerase I; Provisional; Region: PRK05755 471856003782 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471856003783 active site 471856003784 metal binding site 1 [ion binding]; metal-binding site 471856003785 putative 5' ssDNA interaction site; other site 471856003786 metal binding site 3; metal-binding site 471856003787 metal binding site 2 [ion binding]; metal-binding site 471856003788 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471856003789 putative DNA binding site [nucleotide binding]; other site 471856003790 putative metal binding site [ion binding]; other site 471856003791 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471856003792 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471856003793 active site 471856003794 DNA binding site [nucleotide binding] 471856003795 catalytic site [active] 471856003796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856003797 S-adenosylmethionine binding site [chemical binding]; other site 471856003798 6-phosphofructokinase; Provisional; Region: PRK03202 471856003799 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 471856003800 active site 471856003801 ADP/pyrophosphate binding site [chemical binding]; other site 471856003802 dimerization interface [polypeptide binding]; other site 471856003803 allosteric effector site; other site 471856003804 fructose-1,6-bisphosphate binding site; other site 471856003805 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471856003806 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471856003807 RNA binding site [nucleotide binding]; other site 471856003808 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471856003809 RNA binding site [nucleotide binding]; other site 471856003810 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471856003811 RNA binding site [nucleotide binding]; other site 471856003812 S1 RNA binding domain; Region: S1; pfam00575 471856003813 RNA binding site [nucleotide binding]; other site 471856003814 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 471856003815 putative substrate binding pocket [chemical binding]; other site 471856003816 AC domain interface; other site 471856003817 catalytic triad [active] 471856003818 AB domain interface; other site 471856003819 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 471856003820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856003821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856003822 Walker A/P-loop; other site 471856003823 ATP binding site [chemical binding]; other site 471856003824 Q-loop/lid; other site 471856003825 ABC transporter signature motif; other site 471856003826 Walker B; other site 471856003827 D-loop; other site 471856003828 H-loop/switch region; other site 471856003829 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471856003830 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471856003831 CoA-binding site [chemical binding]; other site 471856003832 ATP-binding [chemical binding]; other site 471856003833 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 471856003834 Predicted transcriptional regulator [Transcription]; Region: COG2345 471856003835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856003836 putative DNA binding site [nucleotide binding]; other site 471856003837 putative Zn2+ binding site [ion binding]; other site 471856003838 V4R domain; Region: V4R; cl15268 471856003839 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 471856003840 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 471856003841 [4Fe-4S] binding site [ion binding]; other site 471856003842 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471856003843 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471856003844 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471856003845 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 471856003846 molybdopterin cofactor binding site; other site 471856003847 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 471856003848 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471856003849 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 471856003850 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471856003851 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471856003852 dimer interface [polypeptide binding]; other site 471856003853 putative functional site; other site 471856003854 putative MPT binding site; other site 471856003855 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 471856003856 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 471856003857 trimer interface [polypeptide binding]; other site 471856003858 dimer interface [polypeptide binding]; other site 471856003859 putative active site [active] 471856003860 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471856003861 MPT binding site; other site 471856003862 trimer interface [polypeptide binding]; other site 471856003863 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471856003864 MoaE homodimer interface [polypeptide binding]; other site 471856003865 MoaD interaction [polypeptide binding]; other site 471856003866 active site residues [active] 471856003867 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471856003868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856003869 FeS/SAM binding site; other site 471856003870 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471856003871 Ubiquitin-like proteins; Region: UBQ; cl00155 471856003872 charged pocket; other site 471856003873 hydrophobic patch; other site 471856003874 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 471856003875 active site 471856003876 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471856003877 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 471856003878 ATP binding site [chemical binding]; other site 471856003879 substrate interface [chemical binding]; other site 471856003880 excinuclease ABC subunit B; Provisional; Region: PRK05298 471856003881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856003882 ATP binding site [chemical binding]; other site 471856003883 putative Mg++ binding site [ion binding]; other site 471856003884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856003885 nucleotide binding region [chemical binding]; other site 471856003886 ATP-binding site [chemical binding]; other site 471856003887 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471856003888 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471856003889 substrate binding site [chemical binding]; other site 471856003890 ATP binding site [chemical binding]; other site 471856003891 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 471856003892 YCII-related domain; Region: YCII; cl00999 471856003893 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471856003894 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471856003895 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471856003896 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471856003897 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471856003898 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471856003899 GIY-YIG motif/motif A; other site 471856003900 active site 471856003901 catalytic site [active] 471856003902 putative DNA binding site [nucleotide binding]; other site 471856003903 metal binding site [ion binding]; metal-binding site 471856003904 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471856003905 Helix-hairpin-helix motif; Region: HHH; pfam00633 471856003906 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 471856003907 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 471856003908 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471856003909 putative substrate binding pocket [chemical binding]; other site 471856003910 dimer interface [polypeptide binding]; other site 471856003911 phosphate binding site [ion binding]; other site 471856003912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471856003913 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471856003914 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471856003915 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471856003916 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471856003917 Phosphoglycerate kinase; Region: PGK; pfam00162 471856003918 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471856003919 substrate binding site [chemical binding]; other site 471856003920 hinge regions; other site 471856003921 ADP binding site [chemical binding]; other site 471856003922 catalytic site [active] 471856003923 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471856003924 triosephosphate isomerase; Provisional; Region: PRK14567 471856003925 substrate binding site [chemical binding]; other site 471856003926 dimer interface [polypeptide binding]; other site 471856003927 catalytic triad [active] 471856003928 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471856003929 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471856003930 putative active site [active] 471856003931 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 471856003932 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 471856003933 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471856003934 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471856003935 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471856003936 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471856003937 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471856003938 TPP-binding site [chemical binding]; other site 471856003939 dimer interface [polypeptide binding]; other site 471856003940 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471856003941 PYR/PP interface [polypeptide binding]; other site 471856003942 dimer interface [polypeptide binding]; other site 471856003943 TPP binding site [chemical binding]; other site 471856003944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471856003945 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 471856003946 UbiA prenyltransferase family; Region: UbiA; pfam01040 471856003947 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471856003948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856003949 active site 471856003950 DNA binding site [nucleotide binding] 471856003951 Int/Topo IB signature motif; other site 471856003952 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471856003953 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856003954 P-loop; other site 471856003955 Magnesium ion binding site [ion binding]; other site 471856003956 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856003957 Magnesium ion binding site [ion binding]; other site 471856003958 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471856003959 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 471856003960 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 471856003961 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471856003962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856003963 RNA binding surface [nucleotide binding]; other site 471856003964 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471856003965 active site 471856003966 cytidylate kinase; Provisional; Region: cmk; PRK00023 471856003967 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471856003968 CMP-binding site; other site 471856003969 The sites determining sugar specificity; other site 471856003970 GTP-binding protein Der; Reviewed; Region: PRK03003 471856003971 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471856003972 G1 box; other site 471856003973 GTP/Mg2+ binding site [chemical binding]; other site 471856003974 Switch I region; other site 471856003975 G2 box; other site 471856003976 Switch II region; other site 471856003977 G3 box; other site 471856003978 G4 box; other site 471856003979 G5 box; other site 471856003980 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471856003981 G1 box; other site 471856003982 GTP/Mg2+ binding site [chemical binding]; other site 471856003983 Switch I region; other site 471856003984 G2 box; other site 471856003985 G3 box; other site 471856003986 Switch II region; other site 471856003987 G4 box; other site 471856003988 G5 box; other site 471856003989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471856003990 active site 471856003991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471856003992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856003993 non-specific DNA binding site [nucleotide binding]; other site 471856003994 salt bridge; other site 471856003995 sequence-specific DNA binding site [nucleotide binding]; other site 471856003996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471856003997 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471856003998 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471856003999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471856004000 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471856004001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856004002 active site 471856004003 DNA binding site [nucleotide binding] 471856004004 Int/Topo IB signature motif; other site 471856004005 Uncharacterized conserved protein [Function unknown]; Region: COG1739 471856004006 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471856004007 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471856004008 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471856004009 Protein of unknown function DUF58; Region: DUF58; pfam01882 471856004010 MoxR-like ATPases [General function prediction only]; Region: COG0714 471856004011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856004012 Walker A motif; other site 471856004013 ATP binding site [chemical binding]; other site 471856004014 Walker B motif; other site 471856004015 arginine finger; other site 471856004016 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 471856004017 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 471856004018 Predicted transcriptional regulator [Transcription]; Region: COG2378 471856004019 WYL domain; Region: WYL; pfam13280 471856004020 Predicted transcriptional regulator [Transcription]; Region: COG2378 471856004021 WYL domain; Region: WYL; pfam13280 471856004022 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 471856004023 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 471856004024 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 471856004025 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471856004026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856004027 ATP binding site [chemical binding]; other site 471856004028 putative Mg++ binding site [ion binding]; other site 471856004029 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 471856004030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856004031 nucleotide binding region [chemical binding]; other site 471856004032 ATP-binding site [chemical binding]; other site 471856004033 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471856004034 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471856004035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471856004036 active site 471856004037 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471856004038 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471856004039 putative active site [active] 471856004040 catalytic triad [active] 471856004041 putative dimer interface [polypeptide binding]; other site 471856004042 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471856004043 Ligand binding site; other site 471856004044 Putative Catalytic site; other site 471856004045 DXD motif; other site 471856004046 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471856004047 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 471856004048 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 471856004049 putative active site [active] 471856004050 catalytic site [active] 471856004051 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 471856004052 putative active site [active] 471856004053 catalytic site [active] 471856004054 pyruvate carboxylase; Reviewed; Region: PRK12999 471856004055 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471856004056 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856004057 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471856004058 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471856004059 active site 471856004060 catalytic residues [active] 471856004061 metal binding site [ion binding]; metal-binding site 471856004062 homodimer binding site [polypeptide binding]; other site 471856004063 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471856004064 carboxyltransferase (CT) interaction site; other site 471856004065 biotinylation site [posttranslational modification]; other site 471856004066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471856004067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856004068 P-loop; other site 471856004069 Magnesium ion binding site [ion binding]; other site 471856004070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856004071 Magnesium ion binding site [ion binding]; other site 471856004072 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471856004073 DNA binding residues [nucleotide binding] 471856004074 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471856004075 putative dimer interface [polypeptide binding]; other site 471856004076 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471856004077 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471856004078 DNA binding residues [nucleotide binding] 471856004079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471856004080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471856004081 phosphopeptide binding site; other site 471856004082 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471856004083 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 471856004084 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471856004085 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471856004086 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471856004087 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471856004088 ATP binding site [chemical binding]; other site 471856004089 Mg++ binding site [ion binding]; other site 471856004090 motif III; other site 471856004091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856004092 nucleotide binding region [chemical binding]; other site 471856004093 ATP-binding site [chemical binding]; other site 471856004094 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 471856004095 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471856004096 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 471856004097 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 471856004098 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 471856004099 homodimer interface [polypeptide binding]; other site 471856004100 putative metal binding site [ion binding]; other site 471856004101 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 471856004102 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471856004103 substrate binding site [chemical binding]; other site 471856004104 hexamer interface [polypeptide binding]; other site 471856004105 metal binding site [ion binding]; metal-binding site 471856004106 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471856004107 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471856004108 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 471856004109 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471856004110 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471856004111 putative active site [active] 471856004112 substrate binding site [chemical binding]; other site 471856004113 putative cosubstrate binding site; other site 471856004114 catalytic site [active] 471856004115 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471856004116 substrate binding site [chemical binding]; other site 471856004117 primosome assembly protein PriA; Provisional; Region: PRK14873 471856004118 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471856004119 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471856004120 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471856004121 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471856004122 Flavoprotein; Region: Flavoprotein; pfam02441 471856004123 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471856004124 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471856004125 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 471856004126 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471856004127 Guanylate kinase; Region: Guanylate_kin; pfam00625 471856004128 catalytic site [active] 471856004129 G-X2-G-X-G-K; other site 471856004130 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471856004131 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471856004132 active site 471856004133 dimer interface [polypeptide binding]; other site 471856004134 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471856004135 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471856004136 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856004137 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471856004138 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471856004139 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856004140 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471856004141 IMP binding site; other site 471856004142 dimer interface [polypeptide binding]; other site 471856004143 interdomain contacts; other site 471856004144 partial ornithine binding site; other site 471856004145 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471856004146 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 471856004147 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471856004148 catalytic site [active] 471856004149 subunit interface [polypeptide binding]; other site 471856004150 dihydroorotase; Validated; Region: pyrC; PRK09357 471856004151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471856004152 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471856004153 active site 471856004154 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471856004155 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471856004156 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471856004157 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471856004158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856004159 active site 471856004160 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 471856004161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471856004162 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471856004163 acyl-activating enzyme (AAE) consensus motif; other site 471856004164 AMP binding site [chemical binding]; other site 471856004165 active site 471856004166 CoA binding site [chemical binding]; other site 471856004167 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471856004168 putative RNA binding site [nucleotide binding]; other site 471856004169 elongation factor P; Validated; Region: PRK00529 471856004170 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471856004171 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471856004172 RNA binding site [nucleotide binding]; other site 471856004173 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471856004174 RNA binding site [nucleotide binding]; other site 471856004175 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 471856004176 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471856004177 Dehydroquinase class II; Region: DHquinase_II; pfam01220 471856004178 trimer interface [polypeptide binding]; other site 471856004179 active site 471856004180 dimer interface [polypeptide binding]; other site 471856004181 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471856004182 active site 471856004183 dimer interface [polypeptide binding]; other site 471856004184 metal binding site [ion binding]; metal-binding site 471856004185 shikimate kinase; Reviewed; Region: aroK; PRK00131 471856004186 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471856004187 ADP binding site [chemical binding]; other site 471856004188 magnesium binding site [ion binding]; other site 471856004189 putative shikimate binding site; other site 471856004190 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471856004191 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471856004192 Tetramer interface [polypeptide binding]; other site 471856004193 active site 471856004194 FMN-binding site [chemical binding]; other site 471856004195 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 471856004196 Cell division protein FtsA; Region: FtsA; pfam14450 471856004197 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 471856004198 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 471856004199 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 471856004200 Verru_Chthon cassette protein A; Region: Verru_Chthon_A; TIGR02600 471856004201 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 471856004202 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 471856004203 putative sugar binding sites [chemical binding]; other site 471856004204 Q-X-W motif; other site 471856004205 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 471856004206 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 471856004207 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 471856004208 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 471856004209 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471856004210 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471856004211 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 471856004212 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 471856004213 Walker A motif; other site 471856004214 ATP binding site [chemical binding]; other site 471856004215 Walker B motif; other site 471856004216 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 471856004217 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 471856004218 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 471856004219 Walker A motif; other site 471856004220 ATP binding site [chemical binding]; other site 471856004221 Walker B motif; other site 471856004222 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471856004223 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471856004224 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471856004225 shikimate binding site; other site 471856004226 NAD(P) binding site [chemical binding]; other site 471856004227 YceG-like family; Region: YceG; pfam02618 471856004228 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471856004229 dimerization interface [polypeptide binding]; other site 471856004230 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 471856004231 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471856004232 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471856004233 motif 1; other site 471856004234 active site 471856004235 motif 2; other site 471856004236 motif 3; other site 471856004237 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471856004238 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 471856004239 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471856004240 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471856004241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471856004242 RNA binding surface [nucleotide binding]; other site 471856004243 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471856004244 recombination factor protein RarA; Reviewed; Region: PRK13342 471856004245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856004246 Walker A motif; other site 471856004247 ATP binding site [chemical binding]; other site 471856004248 Walker B motif; other site 471856004249 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471856004250 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471856004251 nudix motif; other site 471856004252 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471856004253 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471856004254 dimer interface [polypeptide binding]; other site 471856004255 anticodon binding site; other site 471856004256 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471856004257 homodimer interface [polypeptide binding]; other site 471856004258 motif 1; other site 471856004259 active site 471856004260 motif 2; other site 471856004261 GAD domain; Region: GAD; pfam02938 471856004262 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471856004263 active site 471856004264 motif 3; other site 471856004265 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471856004266 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471856004267 dimer interface [polypeptide binding]; other site 471856004268 motif 1; other site 471856004269 active site 471856004270 motif 2; other site 471856004271 motif 3; other site 471856004272 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471856004273 anticodon binding site; other site 471856004274 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471856004275 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471856004276 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471856004277 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471856004278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471856004279 Zn2+ binding site [ion binding]; other site 471856004280 Mg2+ binding site [ion binding]; other site 471856004281 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471856004282 synthetase active site [active] 471856004283 NTP binding site [chemical binding]; other site 471856004284 metal binding site [ion binding]; metal-binding site 471856004285 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471856004286 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471856004287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856004288 active site 471856004289 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471856004290 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 471856004291 Protein export membrane protein; Region: SecD_SecF; pfam02355 471856004292 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 471856004293 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 471856004294 Preprotein translocase subunit; Region: YajC; pfam02699 471856004295 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471856004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856004297 Walker A motif; other site 471856004298 ATP binding site [chemical binding]; other site 471856004299 Walker B motif; other site 471856004300 arginine finger; other site 471856004301 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471856004302 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471856004303 RuvA N terminal domain; Region: RuvA_N; pfam01330 471856004304 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471856004305 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471856004306 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 471856004307 active site 471856004308 putative DNA-binding cleft [nucleotide binding]; other site 471856004309 dimer interface [polypeptide binding]; other site 471856004310 hypothetical protein; Validated; Region: PRK00110 471856004311 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471856004312 nudix motif; other site 471856004313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471856004314 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471856004315 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471856004316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471856004317 putative acyl-acceptor binding pocket; other site 471856004318 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471856004319 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471856004320 nucleotide binding site/active site [active] 471856004321 HIT family signature motif; other site 471856004322 catalytic residue [active] 471856004323 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471856004324 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 471856004325 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471856004326 active site 471856004327 dimer interface [polypeptide binding]; other site 471856004328 motif 1; other site 471856004329 motif 2; other site 471856004330 motif 3; other site 471856004331 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471856004332 anticodon binding site; other site 471856004333 Chitin binding domain; Region: Chitin_bind_3; pfam03067 471856004334 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 471856004335 aromatic chitin/cellulose binding site residues [chemical binding]; other site 471856004336 Glyco_18 domain; Region: Glyco_18; smart00636 471856004337 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 471856004338 active site 471856004339 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 471856004340 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471856004341 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471856004342 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 471856004343 homodimer interface [polypeptide binding]; other site 471856004344 substrate-cofactor binding pocket; other site 471856004345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856004346 catalytic residue [active] 471856004347 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 471856004348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856004349 Walker A motif; other site 471856004350 ATP binding site [chemical binding]; other site 471856004351 Walker B motif; other site 471856004352 RibD C-terminal domain; Region: RibD_C; cl17279 471856004353 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471856004354 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471856004355 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471856004356 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 471856004357 catalytic site [active] 471856004358 putative active site [active] 471856004359 putative substrate binding site [chemical binding]; other site 471856004360 HRDC domain; Region: HRDC; pfam00570 471856004361 FemAB family; Region: FemAB; pfam02388 471856004362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 471856004363 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471856004364 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471856004365 dimer interface [polypeptide binding]; other site 471856004366 active site 471856004367 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471856004368 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471856004369 substrate binding site [chemical binding]; other site 471856004370 oxyanion hole (OAH) forming residues; other site 471856004371 trimer interface [polypeptide binding]; other site 471856004372 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 471856004373 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471856004374 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471856004375 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 471856004376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856004377 FeS/SAM binding site; other site 471856004378 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 471856004379 Pyruvate formate lyase 1; Region: PFL1; cd01678 471856004380 coenzyme A binding site [chemical binding]; other site 471856004381 active site 471856004382 catalytic residues [active] 471856004383 glycine loop; other site 471856004384 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471856004385 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471856004386 TPP-binding site; other site 471856004387 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471856004388 PYR/PP interface [polypeptide binding]; other site 471856004389 dimer interface [polypeptide binding]; other site 471856004390 TPP binding site [chemical binding]; other site 471856004391 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471856004392 AzlC protein; Region: AzlC; pfam03591 471856004393 aconitate hydratase; Validated; Region: PRK09277 471856004394 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471856004395 substrate binding site [chemical binding]; other site 471856004396 ligand binding site [chemical binding]; other site 471856004397 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471856004398 substrate binding site [chemical binding]; other site 471856004399 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471856004400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856004401 S-adenosylmethionine binding site [chemical binding]; other site 471856004402 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471856004403 K+ potassium transporter; Region: K_trans; cl15781 471856004404 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471856004405 TrkA-N domain; Region: TrkA_N; pfam02254 471856004406 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471856004407 TrkA-N domain; Region: TrkA_N; pfam02254 471856004408 TrkA-C domain; Region: TrkA_C; pfam02080 471856004409 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471856004410 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471856004411 ssDNA binding site; other site 471856004412 generic binding surface II; other site 471856004413 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471856004414 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471856004415 trimer interface [polypeptide binding]; other site 471856004416 active site 471856004417 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 471856004418 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471856004419 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471856004420 active site 471856004421 dimerization interface [polypeptide binding]; other site 471856004422 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471856004423 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471856004424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471856004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856004426 Coenzyme A binding pocket [chemical binding]; other site 471856004427 CoA binding domain; Region: CoA_binding; cl17356 471856004428 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 471856004429 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 471856004430 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471856004431 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471856004432 CAP-like domain; other site 471856004433 active site 471856004434 primary dimer interface [polypeptide binding]; other site 471856004435 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471856004436 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 471856004437 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471856004438 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 471856004439 substrate binding pocket [chemical binding]; other site 471856004440 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 471856004441 B12 binding site [chemical binding]; other site 471856004442 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471856004443 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 471856004444 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471856004445 Walker A/P-loop; other site 471856004446 ATP binding site [chemical binding]; other site 471856004447 Q-loop/lid; other site 471856004448 ABC transporter signature motif; other site 471856004449 Walker B; other site 471856004450 D-loop; other site 471856004451 H-loop/switch region; other site 471856004452 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471856004453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856004454 Walker A/P-loop; other site 471856004455 ATP binding site [chemical binding]; other site 471856004456 Q-loop/lid; other site 471856004457 ABC transporter signature motif; other site 471856004458 Walker B; other site 471856004459 D-loop; other site 471856004460 H-loop/switch region; other site 471856004461 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471856004462 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856004463 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471856004464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856004465 ATP binding site [chemical binding]; other site 471856004466 Mg2+ binding site [ion binding]; other site 471856004467 G-X-G motif; other site 471856004468 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471856004469 anchoring element; other site 471856004470 dimer interface [polypeptide binding]; other site 471856004471 ATP binding site [chemical binding]; other site 471856004472 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471856004473 active site 471856004474 metal binding site [ion binding]; metal-binding site 471856004475 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471856004476 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471856004477 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471856004478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856004479 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471856004480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471856004481 DNA binding residues [nucleotide binding] 471856004482 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471856004483 Ligand Binding Site [chemical binding]; other site 471856004484 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 471856004485 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471856004486 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471856004487 substrate binding pocket [chemical binding]; other site 471856004488 chain length determination region; other site 471856004489 substrate-Mg2+ binding site; other site 471856004490 catalytic residues [active] 471856004491 aspartate-rich region 1; other site 471856004492 active site lid residues [active] 471856004493 aspartate-rich region 2; other site 471856004494 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471856004495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471856004496 active site 471856004497 ATP binding site [chemical binding]; other site 471856004498 substrate binding site [chemical binding]; other site 471856004499 activation loop (A-loop); other site 471856004500 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856004501 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856004502 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856004503 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471856004504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471856004505 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471856004506 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 471856004507 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 471856004508 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 471856004509 active site 471856004510 ADP/pyrophosphate binding site [chemical binding]; other site 471856004511 dimerization interface [polypeptide binding]; other site 471856004512 allosteric effector site; other site 471856004513 fructose-1,6-bisphosphate binding site; other site 471856004514 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471856004515 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471856004516 putative acyl-acceptor binding pocket; other site 471856004517 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471856004518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856004519 nucleotide binding site [chemical binding]; other site 471856004520 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471856004521 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471856004522 acyl-activating enzyme (AAE) consensus motif; other site 471856004523 putative AMP binding site [chemical binding]; other site 471856004524 putative active site [active] 471856004525 putative CoA binding site [chemical binding]; other site 471856004526 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471856004527 AsnC family; Region: AsnC_trans_reg; pfam01037 471856004528 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471856004529 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471856004530 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471856004531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856004532 active site 471856004533 phosphorylation site [posttranslational modification] 471856004534 intermolecular recognition site; other site 471856004535 dimerization interface [polypeptide binding]; other site 471856004536 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471856004537 Subunit I/III interface [polypeptide binding]; other site 471856004538 cytochrome c-550; Provisional; Region: psbV; cl17239 471856004539 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471856004540 Cytochrome c; Region: Cytochrom_C; pfam00034 471856004541 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471856004542 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471856004543 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471856004544 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471856004545 iron-sulfur cluster [ion binding]; other site 471856004546 [2Fe-2S] cluster binding site [ion binding]; other site 471856004547 Protein of unknown function (DUF3595); Region: DUF3595; pfam12166 471856004548 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471856004549 heme bH binding site [chemical binding]; other site 471856004550 intrachain domain interface; other site 471856004551 heme bL binding site [chemical binding]; other site 471856004552 interchain domain interface [polypeptide binding]; other site 471856004553 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 471856004554 Qo binding site; other site 471856004555 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471856004556 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471856004557 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471856004558 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471856004559 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471856004560 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471856004561 D-pathway; other site 471856004562 Putative ubiquinol binding site [chemical binding]; other site 471856004563 Low-spin heme (heme b) binding site [chemical binding]; other site 471856004564 Putative water exit pathway; other site 471856004565 Binuclear center (heme o3/CuB) [ion binding]; other site 471856004566 K-pathway; other site 471856004567 Putative proton exit pathway; other site 471856004568 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 471856004569 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471856004570 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471856004571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856004572 catalytic residue [active] 471856004573 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471856004574 CPxP motif; other site 471856004575 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 471856004576 quinolinate synthetase; Provisional; Region: PRK09375 471856004577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471856004578 active site 471856004579 hypothetical protein; Provisional; Region: PRK07907 471856004580 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 471856004581 active site 471856004582 metal binding site [ion binding]; metal-binding site 471856004583 dimer interface [polypeptide binding]; other site 471856004584 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471856004585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471856004586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471856004587 active site 471856004588 catalytic tetrad [active] 471856004589 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 471856004590 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 471856004591 quinone interaction residues [chemical binding]; other site 471856004592 active site 471856004593 catalytic residues [active] 471856004594 FMN binding site [chemical binding]; other site 471856004595 substrate binding site [chemical binding]; other site 471856004596 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471856004597 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471856004598 interface (dimer of trimers) [polypeptide binding]; other site 471856004599 Substrate-binding/catalytic site; other site 471856004600 Zn-binding sites [ion binding]; other site 471856004601 CAAX protease self-immunity; Region: Abi; pfam02517 471856004602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856004603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856004604 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471856004605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856004606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471856004607 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471856004608 E3 interaction surface; other site 471856004609 lipoyl attachment site [posttranslational modification]; other site 471856004610 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471856004611 E3 interaction surface; other site 471856004612 lipoyl attachment site [posttranslational modification]; other site 471856004613 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471856004614 E3 interaction surface; other site 471856004615 lipoyl attachment site [posttranslational modification]; other site 471856004616 e3 binding domain; Region: E3_binding; pfam02817 471856004617 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471856004618 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471856004619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856004620 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 471856004621 NAD(P) binding site [chemical binding]; other site 471856004622 active site 471856004623 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471856004624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471856004625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471856004626 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471856004627 lipoyl synthase; Provisional; Region: PRK05481 471856004628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856004629 FeS/SAM binding site; other site 471856004630 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 471856004631 Protease prsW family; Region: PrsW-protease; cl15823 471856004632 RDD family; Region: RDD; pfam06271 471856004633 glutamine synthetase, type I; Region: GlnA; TIGR00653 471856004634 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471856004635 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471856004636 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471856004637 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471856004638 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471856004639 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471856004640 metal binding triad; other site 471856004641 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471856004642 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471856004643 metal binding triad; other site 471856004644 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471856004645 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471856004646 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471856004647 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471856004648 NAD synthetase; Provisional; Region: PRK13981 471856004649 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471856004650 multimer interface [polypeptide binding]; other site 471856004651 active site 471856004652 catalytic triad [active] 471856004653 protein interface 1 [polypeptide binding]; other site 471856004654 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471856004655 homodimer interface [polypeptide binding]; other site 471856004656 NAD binding pocket [chemical binding]; other site 471856004657 ATP binding pocket [chemical binding]; other site 471856004658 Mg binding site [ion binding]; other site 471856004659 active-site loop [active] 471856004660 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471856004661 oligomerization interface [polypeptide binding]; other site 471856004662 active site 471856004663 metal binding site [ion binding]; metal-binding site 471856004664 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471856004665 active site 471856004666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856004667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471856004668 nucleotide binding site [chemical binding]; other site 471856004669 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 471856004670 Protein of unknown function (DUF328); Region: DUF328; pfam03883 471856004671 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471856004672 Putative zinc ribbon domain; Region: DUF164; pfam02591 471856004673 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471856004674 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471856004675 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 471856004676 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471856004677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856004678 S-adenosylmethionine binding site [chemical binding]; other site 471856004679 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471856004680 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471856004681 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471856004682 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471856004683 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471856004684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856004685 ATP binding site [chemical binding]; other site 471856004686 putative Mg++ binding site [ion binding]; other site 471856004687 AAA domain; Region: AAA_13; pfam13166 471856004688 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 471856004689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856004690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856004691 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471856004692 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471856004693 putative active site [active] 471856004694 transaldolase; Provisional; Region: PRK03903 471856004695 catalytic residue [active] 471856004696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471856004697 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471856004698 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471856004699 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471856004700 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471856004701 dimer interface [polypeptide binding]; other site 471856004702 TPP-binding site [chemical binding]; other site 471856004703 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471856004704 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471856004705 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471856004706 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471856004707 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471856004708 dimer interface [polypeptide binding]; other site 471856004709 active site 471856004710 CoA binding pocket [chemical binding]; other site 471856004711 acyl carrier protein; Provisional; Region: acpP; PRK00982 471856004712 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471856004713 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471856004714 dimer interface [polypeptide binding]; other site 471856004715 active site 471856004716 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471856004717 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471856004718 active site 471856004719 catalytic residues [active] 471856004720 metal binding site [ion binding]; metal-binding site 471856004721 DNA primase, catalytic core; Region: dnaG; TIGR01391 471856004722 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471856004723 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471856004724 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471856004725 active site 471856004726 metal binding site [ion binding]; metal-binding site 471856004727 interdomain interaction site; other site 471856004728 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471856004729 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 471856004730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471856004731 Zn2+ binding site [ion binding]; other site 471856004732 Mg2+ binding site [ion binding]; other site 471856004733 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 471856004734 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471856004735 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 471856004736 homodimer interface [polypeptide binding]; other site 471856004737 maltodextrin glucosidase; Provisional; Region: PRK10785 471856004738 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 471856004739 active site 471856004740 homodimer interface [polypeptide binding]; other site 471856004741 catalytic site [active] 471856004742 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856004743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856004744 dimer interface [polypeptide binding]; other site 471856004745 conserved gate region; other site 471856004746 putative PBP binding loops; other site 471856004747 ABC-ATPase subunit interface; other site 471856004748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856004749 dimer interface [polypeptide binding]; other site 471856004750 conserved gate region; other site 471856004751 putative PBP binding loops; other site 471856004752 ABC-ATPase subunit interface; other site 471856004753 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471856004754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856004755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856004756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856004757 DNA binding site [nucleotide binding] 471856004758 domain linker motif; other site 471856004759 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 471856004760 putative dimerization interface [polypeptide binding]; other site 471856004761 putative ligand binding site [chemical binding]; other site 471856004762 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 471856004763 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471856004764 active site 471856004765 catalytic site [active] 471856004766 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471856004767 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471856004768 FMN binding site [chemical binding]; other site 471856004769 active site 471856004770 catalytic residues [active] 471856004771 substrate binding site [chemical binding]; other site 471856004772 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471856004773 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471856004774 motif 1; other site 471856004775 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 471856004776 active site 471856004777 motif 2; other site 471856004778 motif 3; other site 471856004779 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471856004780 anticodon binding site; other site 471856004781 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471856004782 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471856004783 intersubunit interface [polypeptide binding]; other site 471856004784 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471856004785 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471856004786 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471856004787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856004788 ABC-ATPase subunit interface; other site 471856004789 dimer interface [polypeptide binding]; other site 471856004790 putative PBP binding regions; other site 471856004791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471856004792 metal binding site 2 [ion binding]; metal-binding site 471856004793 putative DNA binding helix; other site 471856004794 metal binding site 1 [ion binding]; metal-binding site 471856004795 dimer interface [polypeptide binding]; other site 471856004796 structural Zn2+ binding site [ion binding]; other site 471856004797 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471856004798 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471856004799 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471856004800 catalytic residue [active] 471856004801 putative FPP diphosphate binding site; other site 471856004802 putative FPP binding hydrophobic cleft; other site 471856004803 dimer interface [polypeptide binding]; other site 471856004804 putative IPP diphosphate binding site; other site 471856004805 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471856004806 Recombination protein O N terminal; Region: RecO_N; pfam11967 471856004807 Recombination protein O C terminal; Region: RecO_C; pfam02565 471856004808 2-isopropylmalate synthase; Validated; Region: PRK03739 471856004809 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471856004810 active site 471856004811 catalytic residues [active] 471856004812 metal binding site [ion binding]; metal-binding site 471856004813 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471856004814 GTPase Era; Reviewed; Region: era; PRK00089 471856004815 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471856004816 G1 box; other site 471856004817 GTP/Mg2+ binding site [chemical binding]; other site 471856004818 Switch I region; other site 471856004819 G2 box; other site 471856004820 Switch II region; other site 471856004821 G3 box; other site 471856004822 G4 box; other site 471856004823 G5 box; other site 471856004824 KH domain; Region: KH_2; pfam07650 471856004825 FOG: CBS domain [General function prediction only]; Region: COG0517 471856004826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856004827 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471856004828 FOG: CBS domain [General function prediction only]; Region: COG0517 471856004829 metal-binding heat shock protein; Provisional; Region: PRK00016 471856004830 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471856004831 PhoH-like protein; Region: PhoH; pfam02562 471856004832 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471856004833 nucleotide binding site/active site [active] 471856004834 HIT family signature motif; other site 471856004835 catalytic residue [active] 471856004836 RNA methyltransferase, RsmE family; Region: TIGR00046 471856004837 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 471856004838 chaperone protein DnaJ; Provisional; Region: PRK14278 471856004839 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471856004840 HSP70 interaction site [polypeptide binding]; other site 471856004841 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471856004842 Zn binding sites [ion binding]; other site 471856004843 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471856004844 dimer interface [polypeptide binding]; other site 471856004845 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471856004846 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 471856004847 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471856004848 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 471856004849 coproporphyrinogen III oxidase; Validated; Region: PRK05628 471856004850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856004851 FeS/SAM binding site; other site 471856004852 HemN C-terminal domain; Region: HemN_C; pfam06969 471856004853 GTP-binding protein LepA; Provisional; Region: PRK05433 471856004854 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471856004855 G1 box; other site 471856004856 putative GEF interaction site [polypeptide binding]; other site 471856004857 GTP/Mg2+ binding site [chemical binding]; other site 471856004858 Switch I region; other site 471856004859 G2 box; other site 471856004860 G3 box; other site 471856004861 Switch II region; other site 471856004862 G4 box; other site 471856004863 G5 box; other site 471856004864 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471856004865 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471856004866 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471856004867 PemK-like protein; Region: PemK; pfam02452 471856004868 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471856004869 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 471856004870 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856004871 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471856004872 Walker A/P-loop; other site 471856004873 ATP binding site [chemical binding]; other site 471856004874 Q-loop/lid; other site 471856004875 ABC transporter signature motif; other site 471856004876 Walker B; other site 471856004877 D-loop; other site 471856004878 H-loop/switch region; other site 471856004879 Predicted transcriptional regulators [Transcription]; Region: COG1725 471856004880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856004881 DNA-binding site [nucleotide binding]; DNA binding site 471856004882 hypothetical protein; Reviewed; Region: PRK07914 471856004883 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471856004884 Competence protein; Region: Competence; pfam03772 471856004885 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 471856004886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471856004887 SLBB domain; Region: SLBB; pfam10531 471856004888 comEA protein; Region: comE; TIGR01259 471856004889 Helix-hairpin-helix motif; Region: HHH; pfam00633 471856004890 EDD domain protein, DegV family; Region: DegV; TIGR00762 471856004891 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471856004892 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 471856004893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 471856004894 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 471856004895 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 471856004896 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 471856004897 aminoacyl-tRNA ligase; Region: PLN02563 471856004898 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856004899 active site 471856004900 HIGH motif; other site 471856004901 nucleotide binding site [chemical binding]; other site 471856004902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856004903 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471856004904 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856004905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471856004906 active site 471856004907 KMSKS motif; other site 471856004908 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471856004909 tRNA binding surface [nucleotide binding]; other site 471856004910 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471856004911 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471856004912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856004913 putative substrate translocation pore; other site 471856004914 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471856004915 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471856004916 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471856004917 FeoA domain; Region: FeoA; pfam04023 471856004918 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471856004919 active site 471856004920 metal binding site [ion binding]; metal-binding site 471856004921 malate:quinone oxidoreductase; Validated; Region: PRK05257 471856004922 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 471856004923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471856004924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471856004925 active site 471856004926 catalytic tetrad [active] 471856004927 thymidine kinase; Provisional; Region: PRK04296 471856004928 AAA domain; Region: AAA_30; pfam13604 471856004929 Predicted membrane protein [Function unknown]; Region: COG2860 471856004930 UPF0126 domain; Region: UPF0126; pfam03458 471856004931 UPF0126 domain; Region: UPF0126; pfam03458 471856004932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471856004933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471856004934 Predicted esterase [General function prediction only]; Region: COG0400 471856004935 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 471856004936 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 471856004937 putative active site [active] 471856004938 putative metal binding residues [ion binding]; other site 471856004939 signature motif; other site 471856004940 putative dimer interface [polypeptide binding]; other site 471856004941 putative phosphate binding site [ion binding]; other site 471856004942 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471856004943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471856004944 active site 471856004945 hypothetical protein; Provisional; Region: PRK01842 471856004946 S-formylglutathione hydrolase; Region: PLN02442 471856004947 Putative esterase; Region: Esterase; pfam00756 471856004948 Class I aldolases; Region: Aldolase_Class_I; cl17187 471856004949 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471856004950 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471856004951 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471856004952 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471856004953 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 471856004954 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471856004955 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471856004956 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471856004957 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 471856004958 active site 471856004959 FMN binding site [chemical binding]; other site 471856004960 substrate binding site [chemical binding]; other site 471856004961 putative catalytic residue [active] 471856004962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471856004963 putative phosphoketolase; Provisional; Region: PRK05261 471856004964 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 471856004965 TPP-binding site; other site 471856004966 XFP C-terminal domain; Region: XFP_C; pfam09363 471856004967 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471856004968 hypothetical protein; Provisional; Region: PRK10621 471856004969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856004970 dimer interface [polypeptide binding]; other site 471856004971 conserved gate region; other site 471856004972 putative PBP binding loops; other site 471856004973 ABC-ATPase subunit interface; other site 471856004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856004975 dimer interface [polypeptide binding]; other site 471856004976 conserved gate region; other site 471856004977 ABC-ATPase subunit interface; other site 471856004978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471856004979 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471856004980 substrate binding pocket [chemical binding]; other site 471856004981 membrane-bound complex binding site; other site 471856004982 hinge residues; other site 471856004983 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471856004984 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471856004985 Walker A/P-loop; other site 471856004986 ATP binding site [chemical binding]; other site 471856004987 Q-loop/lid; other site 471856004988 ABC transporter signature motif; other site 471856004989 Walker B; other site 471856004990 D-loop; other site 471856004991 H-loop/switch region; other site 471856004992 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471856004993 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471856004994 G1 box; other site 471856004995 GTP/Mg2+ binding site [chemical binding]; other site 471856004996 G2 box; other site 471856004997 Switch I region; other site 471856004998 G3 box; other site 471856004999 Switch II region; other site 471856005000 G4 box; other site 471856005001 G5 box; other site 471856005002 Nucleoside recognition; Region: Gate; pfam07670 471856005003 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471856005004 FeoA domain; Region: FeoA; pfam04023 471856005005 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471856005006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856005007 DNA-binding site [nucleotide binding]; DNA binding site 471856005008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856005009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856005010 homodimer interface [polypeptide binding]; other site 471856005011 catalytic residue [active] 471856005012 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471856005013 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471856005014 active site 471856005015 multimer interface [polypeptide binding]; other site 471856005016 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471856005017 predicted active site [active] 471856005018 catalytic triad [active] 471856005019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856005020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005021 active site 471856005022 phosphorylation site [posttranslational modification] 471856005023 intermolecular recognition site; other site 471856005024 dimerization interface [polypeptide binding]; other site 471856005025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856005026 DNA binding residues [nucleotide binding] 471856005027 dimerization interface [polypeptide binding]; other site 471856005028 Histidine kinase; Region: HisKA_3; pfam07730 471856005029 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471856005030 ATP binding site [chemical binding]; other site 471856005031 Mg2+ binding site [ion binding]; other site 471856005032 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 471856005033 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471856005034 active site residue [active] 471856005035 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 471856005036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856005037 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471856005038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471856005039 active site residue [active] 471856005040 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471856005041 CPxP motif; other site 471856005042 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 471856005043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471856005044 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471856005045 dimer interface [polypeptide binding]; other site 471856005046 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471856005047 dimer interface [polypeptide binding]; other site 471856005048 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471856005049 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 471856005050 hexamer interface [polypeptide binding]; other site 471856005051 ligand binding site [chemical binding]; other site 471856005052 putative active site [active] 471856005053 NAD(P) binding site [chemical binding]; other site 471856005054 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 471856005055 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471856005056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005057 dimer interface [polypeptide binding]; other site 471856005058 conserved gate region; other site 471856005059 ABC-ATPase subunit interface; other site 471856005060 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471856005061 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 471856005062 Walker A/P-loop; other site 471856005063 ATP binding site [chemical binding]; other site 471856005064 Q-loop/lid; other site 471856005065 ABC transporter signature motif; other site 471856005066 Walker B; other site 471856005067 D-loop; other site 471856005068 H-loop/switch region; other site 471856005069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471856005070 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471856005071 Short C-terminal domain; Region: SHOCT; pfam09851 471856005072 Protein of unknown function (DUF808); Region: DUF808; cl01002 471856005073 metabolite-proton symporter; Region: 2A0106; TIGR00883 471856005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856005075 putative substrate translocation pore; other site 471856005076 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 471856005077 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471856005078 substrate binding site [chemical binding]; other site 471856005079 active site 471856005080 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471856005081 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471856005082 substrate binding site [chemical binding]; other site 471856005083 active site 471856005084 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471856005085 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471856005086 active site 471856005087 catalytic site [active] 471856005088 substrate binding site [chemical binding]; other site 471856005089 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471856005090 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471856005091 Zn binding site [ion binding]; other site 471856005092 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471856005093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856005094 active site 471856005095 motif I; other site 471856005096 motif II; other site 471856005097 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471856005098 Uncharacterized conserved protein [Function unknown]; Region: COG4127 471856005099 Restriction endonuclease; Region: Mrr_cat; pfam04471 471856005100 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 471856005101 pentamer interface [polypeptide binding]; other site 471856005102 dodecaamer interface [polypeptide binding]; other site 471856005103 Protein of unknown function (DUF952); Region: DUF952; pfam06108 471856005104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856005105 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 471856005106 Walker A motif; other site 471856005107 ATP binding site [chemical binding]; other site 471856005108 Walker B motif; other site 471856005109 Uncharacterized conserved protein [Function unknown]; Region: COG3410 471856005110 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 471856005111 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 471856005112 active site 471856005113 metal binding site [ion binding]; metal-binding site 471856005114 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471856005115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471856005116 catalytic core [active] 471856005117 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 471856005118 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471856005119 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471856005120 active site 471856005121 (T/H)XGH motif; other site 471856005122 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471856005123 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471856005124 putative catalytic cysteine [active] 471856005125 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 471856005126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856005127 catalytic residue [active] 471856005128 MFS/sugar transport protein; Region: MFS_2; pfam13347 471856005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856005130 putative substrate translocation pore; other site 471856005131 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 471856005132 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 471856005133 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471856005134 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 471856005135 Ca binding site [ion binding]; other site 471856005136 carbohydrate binding site [chemical binding]; other site 471856005137 gamma-glutamyl kinase; Provisional; Region: PRK05429 471856005138 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471856005139 nucleotide binding site [chemical binding]; other site 471856005140 homotetrameric interface [polypeptide binding]; other site 471856005141 putative phosphate binding site [ion binding]; other site 471856005142 putative allosteric binding site; other site 471856005143 PUA domain; Region: PUA; pfam01472 471856005144 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471856005145 GTP1/OBG; Region: GTP1_OBG; pfam01018 471856005146 Obg GTPase; Region: Obg; cd01898 471856005147 G1 box; other site 471856005148 GTP/Mg2+ binding site [chemical binding]; other site 471856005149 Switch I region; other site 471856005150 G2 box; other site 471856005151 G3 box; other site 471856005152 Switch II region; other site 471856005153 G4 box; other site 471856005154 G5 box; other site 471856005155 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 471856005156 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471856005157 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471856005158 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471856005159 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471856005160 homodimer interface [polypeptide binding]; other site 471856005161 oligonucleotide binding site [chemical binding]; other site 471856005162 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471856005163 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471856005164 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471856005165 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471856005166 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471856005167 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471856005168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856005169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856005170 Walker A/P-loop; other site 471856005171 ATP binding site [chemical binding]; other site 471856005172 Q-loop/lid; other site 471856005173 ABC transporter signature motif; other site 471856005174 Walker B; other site 471856005175 D-loop; other site 471856005176 H-loop/switch region; other site 471856005177 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 471856005178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856005179 Walker A/P-loop; other site 471856005180 ATP binding site [chemical binding]; other site 471856005181 Q-loop/lid; other site 471856005182 ABC transporter signature motif; other site 471856005183 Walker B; other site 471856005184 D-loop; other site 471856005185 H-loop/switch region; other site 471856005186 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471856005187 GAF domain; Region: GAF_3; pfam13492 471856005188 Histidine kinase; Region: HisKA_3; pfam07730 471856005189 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471856005190 Mg2+ binding site [ion binding]; other site 471856005191 G-X-G motif; other site 471856005192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856005193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005194 active site 471856005195 phosphorylation site [posttranslational modification] 471856005196 intermolecular recognition site; other site 471856005197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856005198 DNA binding residues [nucleotide binding] 471856005199 dimerization interface [polypeptide binding]; other site 471856005200 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 471856005201 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471856005202 putative ligand binding site [chemical binding]; other site 471856005203 putative NAD binding site [chemical binding]; other site 471856005204 catalytic site [active] 471856005205 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 471856005206 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 471856005207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471856005208 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856005209 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471856005210 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471856005211 DNA binding site [nucleotide binding] 471856005212 catalytic residue [active] 471856005213 H2TH interface [polypeptide binding]; other site 471856005214 putative catalytic residues [active] 471856005215 turnover-facilitating residue; other site 471856005216 intercalation triad [nucleotide binding]; other site 471856005217 8OG recognition residue [nucleotide binding]; other site 471856005218 putative reading head residues; other site 471856005219 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471856005220 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471856005221 ribonuclease III; Reviewed; Region: rnc; PRK00102 471856005222 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471856005223 dimerization interface [polypeptide binding]; other site 471856005224 active site 471856005225 metal binding site [ion binding]; metal-binding site 471856005226 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471856005227 dsRNA binding site [nucleotide binding]; other site 471856005228 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471856005229 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 471856005230 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471856005231 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471856005232 active site 471856005233 (T/H)XGH motif; other site 471856005234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 471856005235 Coenzyme A binding pocket [chemical binding]; other site 471856005236 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 471856005237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856005238 S-adenosylmethionine binding site [chemical binding]; other site 471856005239 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471856005240 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471856005241 ssDNA binding site; other site 471856005242 generic binding surface II; other site 471856005243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856005244 ATP binding site [chemical binding]; other site 471856005245 putative Mg++ binding site [ion binding]; other site 471856005246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856005247 nucleotide binding region [chemical binding]; other site 471856005248 ATP-binding site [chemical binding]; other site 471856005249 DAK2 domain; Region: Dak2; pfam02734 471856005250 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471856005251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471856005252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856005253 Coenzyme A binding pocket [chemical binding]; other site 471856005254 thiamine monophosphate kinase; Provisional; Region: PRK05731 471856005255 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471856005256 ATP binding site [chemical binding]; other site 471856005257 dimerization interface [polypeptide binding]; other site 471856005258 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471856005259 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471856005260 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471856005261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856005262 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471856005263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471856005264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856005265 catalytic residue [active] 471856005266 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471856005267 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471856005268 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471856005269 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471856005270 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471856005271 putative acyl-acceptor binding pocket; other site 471856005272 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471856005273 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471856005274 hinge; other site 471856005275 active site 471856005276 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471856005277 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471856005278 Bacterial transcriptional regulator; Region: IclR; pfam01614 471856005279 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471856005280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856005281 motif II; other site 471856005282 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471856005283 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471856005284 HIGH motif; other site 471856005285 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471856005286 active site 471856005287 KMSKS motif; other site 471856005288 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471856005289 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471856005290 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471856005291 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471856005292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856005293 S-adenosylmethionine binding site [chemical binding]; other site 471856005294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471856005295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471856005296 active site 471856005297 catalytic tetrad [active] 471856005298 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471856005299 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471856005300 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471856005301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856005302 ATP binding site [chemical binding]; other site 471856005303 putative Mg++ binding site [ion binding]; other site 471856005304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856005305 nucleotide binding region [chemical binding]; other site 471856005306 ATP-binding site [chemical binding]; other site 471856005307 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471856005308 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471856005309 putative deacylase active site [active] 471856005310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471856005311 hypothetical protein; Provisional; Region: PRK11770 471856005312 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471856005313 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471856005314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471856005315 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471856005316 catalytic residue [active] 471856005317 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471856005318 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471856005319 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 471856005320 active site 471856005321 catalytic residues [active] 471856005322 metal binding site [ion binding]; metal-binding site 471856005323 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471856005324 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471856005325 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471856005326 homodimer interface [polypeptide binding]; other site 471856005327 substrate-cofactor binding pocket; other site 471856005328 catalytic residue [active] 471856005329 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 471856005330 tartrate dehydrogenase; Provisional; Region: PRK08194 471856005331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856005332 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471856005333 Walker A/P-loop; other site 471856005334 ATP binding site [chemical binding]; other site 471856005335 Q-loop/lid; other site 471856005336 ABC transporter signature motif; other site 471856005337 Walker B; other site 471856005338 D-loop; other site 471856005339 H-loop/switch region; other site 471856005340 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471856005341 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 471856005342 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471856005343 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471856005344 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471856005345 putative valine binding site [chemical binding]; other site 471856005346 dimer interface [polypeptide binding]; other site 471856005347 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471856005348 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471856005349 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471856005350 PYR/PP interface [polypeptide binding]; other site 471856005351 dimer interface [polypeptide binding]; other site 471856005352 TPP binding site [chemical binding]; other site 471856005353 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 471856005354 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471856005355 TPP-binding site [chemical binding]; other site 471856005356 dimer interface [polypeptide binding]; other site 471856005357 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 471856005358 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471856005359 Coenzyme A binding pocket [chemical binding]; other site 471856005360 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471856005361 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471856005362 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471856005363 GatB domain; Region: GatB_Yqey; smart00845 471856005364 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471856005365 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471856005366 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471856005367 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471856005368 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471856005369 nucleotide binding pocket [chemical binding]; other site 471856005370 K-X-D-G motif; other site 471856005371 catalytic site [active] 471856005372 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471856005373 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471856005374 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471856005375 Dimer interface [polypeptide binding]; other site 471856005376 BRCT sequence motif; other site 471856005377 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471856005378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471856005379 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471856005380 nudix motif; other site 471856005381 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856005382 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471856005383 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471856005384 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471856005385 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471856005386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856005387 catalytic residue [active] 471856005388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471856005389 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471856005390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471856005391 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471856005392 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471856005393 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471856005394 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471856005395 Ligand binding site [chemical binding]; other site 471856005396 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471856005397 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471856005398 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471856005399 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471856005400 active site 471856005401 catalytic site [active] 471856005402 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 471856005403 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 471856005404 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471856005405 active site 471856005406 homodimer interface [polypeptide binding]; other site 471856005407 catalytic site [active] 471856005408 acceptor binding site [chemical binding]; other site 471856005409 trehalose synthase; Region: treS_nterm; TIGR02456 471856005410 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471856005411 active site 471856005412 catalytic site [active] 471856005413 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471856005414 glycogen branching enzyme; Provisional; Region: PRK05402 471856005415 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471856005416 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471856005417 active site 471856005418 catalytic site [active] 471856005419 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471856005420 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471856005421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471856005422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471856005423 binding surface 471856005424 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 471856005425 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 471856005426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471856005427 TAP-like protein; Region: Abhydrolase_4; pfam08386 471856005428 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471856005429 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 471856005430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856005431 active site 471856005432 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471856005433 active site 471856005434 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 471856005435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856005436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856005437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471856005438 FtsX-like permease family; Region: FtsX; pfam02687 471856005439 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471856005440 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856005441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856005442 Walker A/P-loop; other site 471856005443 ATP binding site [chemical binding]; other site 471856005444 Q-loop/lid; other site 471856005445 ABC transporter signature motif; other site 471856005446 Walker B; other site 471856005447 D-loop; other site 471856005448 H-loop/switch region; other site 471856005449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856005450 ABC transporter signature motif; other site 471856005451 Walker B; other site 471856005452 D-loop; other site 471856005453 H-loop/switch region; other site 471856005454 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 471856005455 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471856005456 dimer interface [polypeptide binding]; other site 471856005457 putative radical transfer pathway; other site 471856005458 diiron center [ion binding]; other site 471856005459 tyrosyl radical; other site 471856005460 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 471856005461 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 471856005462 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471856005463 active site 471856005464 dimer interface [polypeptide binding]; other site 471856005465 catalytic residues [active] 471856005466 effector binding site; other site 471856005467 R2 peptide binding site; other site 471856005468 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471856005469 catalytic residues [active] 471856005470 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 471856005471 beta-galactosidase; Region: BGL; TIGR03356 471856005472 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471856005473 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856005474 ligand binding site [chemical binding]; other site 471856005475 dimerization interface [polypeptide binding]; other site 471856005476 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471856005477 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471856005478 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471856005479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856005480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005481 dimer interface [polypeptide binding]; other site 471856005482 conserved gate region; other site 471856005483 putative PBP binding loops; other site 471856005484 ABC-ATPase subunit interface; other site 471856005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005486 dimer interface [polypeptide binding]; other site 471856005487 conserved gate region; other site 471856005488 putative PBP binding loops; other site 471856005489 ABC-ATPase subunit interface; other site 471856005490 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856005491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856005492 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856005493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856005494 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 471856005495 dimerization interface [polypeptide binding]; other site 471856005496 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 471856005497 putative active cleft [active] 471856005498 putative alpha-glucosidase; Provisional; Region: PRK10658 471856005499 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471856005500 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 471856005501 active site 471856005502 homotrimer interface [polypeptide binding]; other site 471856005503 catalytic site [active] 471856005504 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 471856005505 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471856005506 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471856005507 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471856005508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856005509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856005510 DNA binding site [nucleotide binding] 471856005511 domain linker motif; other site 471856005512 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856005513 dimerization interface [polypeptide binding]; other site 471856005514 ligand binding site [chemical binding]; other site 471856005515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856005516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005517 dimer interface [polypeptide binding]; other site 471856005518 conserved gate region; other site 471856005519 putative PBP binding loops; other site 471856005520 ABC-ATPase subunit interface; other site 471856005521 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471856005522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005523 dimer interface [polypeptide binding]; other site 471856005524 conserved gate region; other site 471856005525 ABC-ATPase subunit interface; other site 471856005526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856005527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471856005528 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471856005529 hypothetical protein; Provisional; Region: PRK03298 471856005530 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471856005531 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471856005532 gamma subunit interface [polypeptide binding]; other site 471856005533 LBP interface [polypeptide binding]; other site 471856005534 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471856005535 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471856005536 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471856005537 alpha subunit interaction interface [polypeptide binding]; other site 471856005538 Walker A motif; other site 471856005539 ATP binding site [chemical binding]; other site 471856005540 Walker B motif; other site 471856005541 inhibitor binding site; inhibition site 471856005542 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471856005543 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471856005544 core domain interface [polypeptide binding]; other site 471856005545 delta subunit interface [polypeptide binding]; other site 471856005546 epsilon subunit interface [polypeptide binding]; other site 471856005547 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471856005548 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471856005549 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471856005550 beta subunit interaction interface [polypeptide binding]; other site 471856005551 Walker A motif; other site 471856005552 ATP binding site [chemical binding]; other site 471856005553 Walker B motif; other site 471856005554 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471856005555 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 471856005556 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471856005557 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 471856005558 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471856005559 ATP synthase subunit C; Region: ATP-synt_C; cl00466 471856005560 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 471856005561 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 471856005562 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471856005563 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471856005564 Mg++ binding site [ion binding]; other site 471856005565 putative catalytic motif [active] 471856005566 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471856005567 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471856005568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856005569 S-adenosylmethionine binding site [chemical binding]; other site 471856005570 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471856005571 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471856005572 RF-1 domain; Region: RF-1; pfam00472 471856005573 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 471856005574 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471856005575 transcription termination factor Rho; Provisional; Region: PRK12608 471856005576 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471856005577 RNA binding site [nucleotide binding]; other site 471856005578 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471856005579 multimer interface [polypeptide binding]; other site 471856005580 Walker A motif; other site 471856005581 ATP binding site [chemical binding]; other site 471856005582 Walker B motif; other site 471856005583 homoserine kinase; Provisional; Region: PRK01212 471856005584 threonine synthase; Reviewed; Region: PRK06721 471856005585 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471856005586 homodimer interface [polypeptide binding]; other site 471856005587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856005588 catalytic residue [active] 471856005589 homoserine dehydrogenase; Provisional; Region: PRK06349 471856005590 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 471856005591 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471856005592 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471856005593 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471856005594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471856005595 active site 471856005596 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471856005597 substrate binding site [chemical binding]; other site 471856005598 catalytic residues [active] 471856005599 dimer interface [polypeptide binding]; other site 471856005600 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471856005601 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 471856005602 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471856005603 active site 471856005604 HIGH motif; other site 471856005605 KMSK motif region; other site 471856005606 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471856005607 tRNA binding surface [nucleotide binding]; other site 471856005608 anticodon binding site; other site 471856005609 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471856005610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856005611 DNA-binding site [nucleotide binding]; DNA binding site 471856005612 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471856005613 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471856005614 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471856005615 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471856005616 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471856005617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856005618 dimerization interface [polypeptide binding]; other site 471856005619 putative DNA binding site [nucleotide binding]; other site 471856005620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856005621 putative Zn2+ binding site [ion binding]; other site 471856005622 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 471856005623 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 471856005624 putative catalytic cysteine [active] 471856005625 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 471856005626 putative active site [active] 471856005627 metal binding site [ion binding]; metal-binding site 471856005628 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471856005629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856005630 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471856005631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856005632 Transporter associated domain; Region: CorC_HlyC; smart01091 471856005633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856005634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005635 active site 471856005636 phosphorylation site [posttranslational modification] 471856005637 intermolecular recognition site; other site 471856005638 dimerization interface [polypeptide binding]; other site 471856005639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856005640 DNA binding site [nucleotide binding] 471856005641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856005642 dimerization interface [polypeptide binding]; other site 471856005643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856005644 dimer interface [polypeptide binding]; other site 471856005645 phosphorylation site [posttranslational modification] 471856005646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856005647 ATP binding site [chemical binding]; other site 471856005648 Mg2+ binding site [ion binding]; other site 471856005649 G-X-G motif; other site 471856005650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471856005651 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471856005652 Walker A/P-loop; other site 471856005653 ATP binding site [chemical binding]; other site 471856005654 Q-loop/lid; other site 471856005655 ABC transporter signature motif; other site 471856005656 Walker B; other site 471856005657 D-loop; other site 471856005658 H-loop/switch region; other site 471856005659 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471856005660 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471856005661 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471856005662 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471856005663 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471856005664 TPP-binding site [chemical binding]; other site 471856005665 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471856005666 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471856005667 active site 471856005668 catalytic triad [active] 471856005669 oxyanion hole [active] 471856005670 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 471856005671 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471856005672 Walker A motif; other site 471856005673 ATP binding site [chemical binding]; other site 471856005674 Walker B motif; other site 471856005675 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 471856005676 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 471856005677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856005678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471856005679 DNA binding residues [nucleotide binding] 471856005680 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471856005681 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471856005682 hinge; other site 471856005683 active site 471856005684 ribosome small subunit-dependent GTPase A; Region: TIGR00157 471856005685 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471856005686 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471856005687 GTP/Mg2+ binding site [chemical binding]; other site 471856005688 G4 box; other site 471856005689 G5 box; other site 471856005690 G1 box; other site 471856005691 Switch I region; other site 471856005692 G2 box; other site 471856005693 G3 box; other site 471856005694 Switch II region; other site 471856005695 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471856005696 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471856005697 active site 471856005698 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 471856005699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 471856005700 Helix-turn-helix domain; Region: HTH_17; pfam12728 471856005701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471856005702 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471856005703 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471856005704 ATP binding site [chemical binding]; other site 471856005705 putative Mg++ binding site [ion binding]; other site 471856005706 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471856005707 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471856005708 30S subunit binding site; other site 471856005709 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471856005710 lipoprotein LpqB; Provisional; Region: PRK13614 471856005711 Sporulation and spore germination; Region: Germane; pfam10646 471856005712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471856005713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856005714 dimerization interface [polypeptide binding]; other site 471856005715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856005716 dimer interface [polypeptide binding]; other site 471856005717 phosphorylation site [posttranslational modification] 471856005718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856005719 ATP binding site [chemical binding]; other site 471856005720 Mg2+ binding site [ion binding]; other site 471856005721 G-X-G motif; other site 471856005722 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856005723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005724 active site 471856005725 phosphorylation site [posttranslational modification] 471856005726 intermolecular recognition site; other site 471856005727 dimerization interface [polypeptide binding]; other site 471856005728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856005729 DNA binding site [nucleotide binding] 471856005730 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 471856005731 MoxR-like ATPases [General function prediction only]; Region: COG0714 471856005732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856005733 Walker A motif; other site 471856005734 ATP binding site [chemical binding]; other site 471856005735 Walker B motif; other site 471856005736 arginine finger; other site 471856005737 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471856005738 Protein of unknown function DUF58; Region: DUF58; pfam01882 471856005739 Integral membrane protein DUF95; Region: DUF95; pfam01944 471856005740 RDD family; Region: RDD; pfam06271 471856005741 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471856005742 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 471856005743 homotetramer interface [polypeptide binding]; other site 471856005744 ligand binding site [chemical binding]; other site 471856005745 catalytic site [active] 471856005746 NAD binding site [chemical binding]; other site 471856005747 Stage II sporulation protein; Region: SpoIID; pfam08486 471856005748 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 471856005749 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471856005750 putative catalytic site [active] 471856005751 putative metal binding site [ion binding]; other site 471856005752 putative phosphate binding site [ion binding]; other site 471856005753 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471856005754 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471856005755 substrate binding site; other site 471856005756 dimer interface; other site 471856005757 short chain dehydrogenase; Provisional; Region: PRK08219 471856005758 classical (c) SDRs; Region: SDR_c; cd05233 471856005759 NAD(P) binding site [chemical binding]; other site 471856005760 active site 471856005761 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471856005762 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471856005763 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 471856005764 Walker A/P-loop; other site 471856005765 ATP binding site [chemical binding]; other site 471856005766 Q-loop/lid; other site 471856005767 ABC transporter signature motif; other site 471856005768 Walker B; other site 471856005769 D-loop; other site 471856005770 H-loop/switch region; other site 471856005771 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 471856005772 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471856005773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471856005774 active site 471856005775 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471856005776 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471856005777 CHAP domain; Region: CHAP; cl17642 471856005778 CHAP domain; Region: CHAP; cl17642 471856005779 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 471856005780 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471856005781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856005782 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471856005783 Walker A/P-loop; other site 471856005784 ATP binding site [chemical binding]; other site 471856005785 Q-loop/lid; other site 471856005786 ABC transporter signature motif; other site 471856005787 Walker B; other site 471856005788 D-loop; other site 471856005789 H-loop/switch region; other site 471856005790 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471856005791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005792 dimer interface [polypeptide binding]; other site 471856005793 conserved gate region; other site 471856005794 putative PBP binding loops; other site 471856005795 ABC-ATPase subunit interface; other site 471856005796 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 471856005797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471856005798 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471856005799 DNA binding residues [nucleotide binding] 471856005800 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 471856005801 Trm112p-like protein; Region: Trm112p; cl01066 471856005802 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471856005803 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 471856005804 active site 471856005805 substrate binding site [chemical binding]; other site 471856005806 metal binding site [ion binding]; metal-binding site 471856005807 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471856005808 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 471856005809 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471856005810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471856005811 active site 471856005812 Transcription factor WhiB; Region: Whib; pfam02467 471856005813 TIGR03089 family protein; Region: TIGR03089 471856005814 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471856005815 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471856005816 NAD binding site [chemical binding]; other site 471856005817 substrate binding site [chemical binding]; other site 471856005818 homodimer interface [polypeptide binding]; other site 471856005819 active site 471856005820 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471856005821 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471856005822 AIR carboxylase; Region: AIRC; pfam00731 471856005823 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471856005824 LabA_like proteins; Region: LabA_like/DUF88; cl10034 471856005825 ATP-grasp domain; Region: ATP-grasp; pfam02222 471856005826 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471856005827 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471856005828 catalytic site [active] 471856005829 Predicted membrane protein [Function unknown]; Region: COG2246 471856005830 GtrA-like protein; Region: GtrA; pfam04138 471856005831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471856005832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471856005833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856005834 dimer interface [polypeptide binding]; other site 471856005835 phosphorylation site [posttranslational modification] 471856005836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856005837 Mg2+ binding site [ion binding]; other site 471856005838 G-X-G motif; other site 471856005839 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856005840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005841 active site 471856005842 phosphorylation site [posttranslational modification] 471856005843 intermolecular recognition site; other site 471856005844 dimerization interface [polypeptide binding]; other site 471856005845 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856005846 DNA binding site [nucleotide binding] 471856005847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471856005848 Histidine kinase; Region: HisKA_3; pfam07730 471856005849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856005850 ATP binding site [chemical binding]; other site 471856005851 Mg2+ binding site [ion binding]; other site 471856005852 G-X-G motif; other site 471856005853 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856005854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856005855 active site 471856005856 phosphorylation site [posttranslational modification] 471856005857 intermolecular recognition site; other site 471856005858 dimerization interface [polypeptide binding]; other site 471856005859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856005860 DNA binding residues [nucleotide binding] 471856005861 dimerization interface [polypeptide binding]; other site 471856005862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856005863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856005864 Walker A/P-loop; other site 471856005865 ATP binding site [chemical binding]; other site 471856005866 Q-loop/lid; other site 471856005867 ABC transporter signature motif; other site 471856005868 Walker B; other site 471856005869 D-loop; other site 471856005870 H-loop/switch region; other site 471856005871 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471856005872 FtsX-like permease family; Region: FtsX; pfam02687 471856005873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471856005874 FtsX-like permease family; Region: FtsX; pfam02687 471856005875 Transcription factor WhiB; Region: Whib; pfam02467 471856005876 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856005877 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856005878 DNA binding site [nucleotide binding] 471856005879 domain linker motif; other site 471856005880 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471856005881 putative dimerization interface [polypeptide binding]; other site 471856005882 putative ligand binding site [chemical binding]; other site 471856005883 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 471856005884 beta-galactosidase; Region: BGL; TIGR03356 471856005885 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856005886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005887 dimer interface [polypeptide binding]; other site 471856005888 conserved gate region; other site 471856005889 putative PBP binding loops; other site 471856005890 ABC-ATPase subunit interface; other site 471856005891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856005892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856005893 conserved gate region; other site 471856005894 dimer interface [polypeptide binding]; other site 471856005895 putative PBP binding loops; other site 471856005896 ABC-ATPase subunit interface; other site 471856005897 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856005898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856005899 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 471856005900 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471856005901 PAS fold; Region: PAS_4; pfam08448 471856005902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471856005903 Histidine kinase; Region: HisKA_2; pfam07568 471856005904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471856005905 ATP binding site [chemical binding]; other site 471856005906 Mg2+ binding site [ion binding]; other site 471856005907 G-X-G motif; other site 471856005908 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 471856005909 ferrochelatase; Reviewed; Region: hemH; PRK00035 471856005910 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471856005911 C-terminal domain interface [polypeptide binding]; other site 471856005912 active site 471856005913 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471856005914 active site 471856005915 N-terminal domain interface [polypeptide binding]; other site 471856005916 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471856005917 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471856005918 catalytic residue [active] 471856005919 putative FPP diphosphate binding site; other site 471856005920 putative FPP binding hydrophobic cleft; other site 471856005921 dimer interface [polypeptide binding]; other site 471856005922 putative IPP diphosphate binding site; other site 471856005923 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 471856005924 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471856005925 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 471856005926 putative active site [active] 471856005927 catalytic triad [active] 471856005928 putative dimer interface [polypeptide binding]; other site 471856005929 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471856005930 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 471856005931 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471856005932 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471856005933 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471856005934 threonine dehydratase; Provisional; Region: PRK08198 471856005935 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471856005936 tetramer interface [polypeptide binding]; other site 471856005937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856005938 catalytic residue [active] 471856005939 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471856005940 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471856005941 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471856005942 methionine sulfoxide reductase A; Provisional; Region: PRK00058 471856005943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471856005944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471856005945 dimerization interface [polypeptide binding]; other site 471856005946 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471856005947 Bax inhibitor 1 like; Region: BaxI_1; cl17691 471856005948 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 471856005949 intracellular protease, PfpI family; Region: PfpI; TIGR01382 471856005950 proposed catalytic triad [active] 471856005951 conserved cys residue [active] 471856005952 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471856005953 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 471856005954 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 471856005955 putative metal binding residues [ion binding]; other site 471856005956 signature motif; other site 471856005957 dimer interface [polypeptide binding]; other site 471856005958 active site 471856005959 polyP binding site; other site 471856005960 substrate binding site [chemical binding]; other site 471856005961 acceptor-phosphate pocket; other site 471856005962 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471856005963 MgtE intracellular N domain; Region: MgtE_N; pfam03448 471856005964 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471856005965 Divalent cation transporter; Region: MgtE; pfam01769 471856005966 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471856005967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471856005968 Walker A/P-loop; other site 471856005969 ATP binding site [chemical binding]; other site 471856005970 Q-loop/lid; other site 471856005971 ABC transporter signature motif; other site 471856005972 Walker B; other site 471856005973 D-loop; other site 471856005974 H-loop/switch region; other site 471856005975 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471856005976 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471856005977 siderophore binding site; other site 471856005978 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471856005979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856005980 ABC-ATPase subunit interface; other site 471856005981 dimer interface [polypeptide binding]; other site 471856005982 putative PBP binding regions; other site 471856005983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856005984 ABC-ATPase subunit interface; other site 471856005985 dimer interface [polypeptide binding]; other site 471856005986 putative PBP binding regions; other site 471856005987 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471856005988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856005989 S-adenosylmethionine binding site [chemical binding]; other site 471856005990 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 471856005991 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856005992 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 471856005993 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471856005994 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 471856005995 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 471856005996 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856005997 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 471856005998 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471856005999 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471856006000 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471856006001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856006002 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471856006003 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471856006004 Protein of unknown function (DUF501); Region: DUF501; cl00652 471856006005 Septum formation initiator; Region: DivIC; pfam04977 471856006006 enolase; Provisional; Region: eno; PRK00077 471856006007 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471856006008 dimer interface [polypeptide binding]; other site 471856006009 metal binding site [ion binding]; metal-binding site 471856006010 substrate binding pocket [chemical binding]; other site 471856006011 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 471856006012 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471856006013 homodimer interface [polypeptide binding]; other site 471856006014 metal binding site [ion binding]; metal-binding site 471856006015 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 471856006016 active site 471856006017 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471856006018 Ca binding site [ion binding]; other site 471856006019 catalytic site [active] 471856006020 Aamy_C domain; Region: Aamy_C; smart00632 471856006021 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 471856006022 Carbohydrate binding domain; Region: CBM_25; smart01066 471856006023 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 471856006024 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471856006025 active site 471856006026 Ca binding site [ion binding]; other site 471856006027 catalytic site [active] 471856006028 Aamy_C domain; Region: Aamy_C; smart00632 471856006029 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 471856006030 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 471856006031 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 471856006032 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 471856006033 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 471856006034 substrate binding site [chemical binding]; other site 471856006035 active site 471856006036 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471856006037 metal binding site [ion binding]; metal-binding site 471856006038 ligand binding site [chemical binding]; other site 471856006039 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471856006040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856006041 Walker A/P-loop; other site 471856006042 ATP binding site [chemical binding]; other site 471856006043 Q-loop/lid; other site 471856006044 ABC transporter signature motif; other site 471856006045 Walker B; other site 471856006046 D-loop; other site 471856006047 H-loop/switch region; other site 471856006048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471856006049 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471856006050 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471856006051 Walker A/P-loop; other site 471856006052 ATP binding site [chemical binding]; other site 471856006053 Q-loop/lid; other site 471856006054 ABC transporter signature motif; other site 471856006055 Walker B; other site 471856006056 D-loop; other site 471856006057 H-loop/switch region; other site 471856006058 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471856006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006060 ABC-ATPase subunit interface; other site 471856006061 putative PBP binding loops; other site 471856006062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471856006063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006064 dimer interface [polypeptide binding]; other site 471856006065 conserved gate region; other site 471856006066 putative PBP binding loops; other site 471856006067 ABC-ATPase subunit interface; other site 471856006068 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471856006069 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471856006070 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 471856006071 hypothetical protein; Reviewed; Region: PRK09588 471856006072 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471856006073 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 471856006074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856006075 ATP binding site [chemical binding]; other site 471856006076 putative Mg++ binding site [ion binding]; other site 471856006077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856006078 nucleotide binding region [chemical binding]; other site 471856006079 ATP-binding site [chemical binding]; other site 471856006080 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 471856006081 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 471856006082 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471856006083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471856006084 ligand binding site [chemical binding]; other site 471856006085 flexible hinge region; other site 471856006086 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471856006087 putative switch regulator; other site 471856006088 non-specific DNA interactions [nucleotide binding]; other site 471856006089 DNA binding site [nucleotide binding] 471856006090 sequence specific DNA binding site [nucleotide binding]; other site 471856006091 putative cAMP binding site [chemical binding]; other site 471856006092 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471856006093 putative active site [active] 471856006094 catalytic residue [active] 471856006095 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471856006096 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471856006097 5S rRNA interface [nucleotide binding]; other site 471856006098 CTC domain interface [polypeptide binding]; other site 471856006099 L16 interface [polypeptide binding]; other site 471856006100 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471856006101 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 471856006102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856006103 active site 471856006104 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471856006105 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471856006106 Substrate binding site; other site 471856006107 Mg++ binding site; other site 471856006108 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471856006109 active site 471856006110 substrate binding site [chemical binding]; other site 471856006111 CoA binding site [chemical binding]; other site 471856006112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856006113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856006114 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471856006115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856006116 Walker A/P-loop; other site 471856006117 ATP binding site [chemical binding]; other site 471856006118 Q-loop/lid; other site 471856006119 ABC transporter signature motif; other site 471856006120 Walker B; other site 471856006121 D-loop; other site 471856006122 H-loop/switch region; other site 471856006123 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471856006124 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471856006125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471856006126 DNA-binding site [nucleotide binding]; DNA binding site 471856006127 FCD domain; Region: FCD; pfam07729 471856006128 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471856006129 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471856006130 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471856006131 MarR family; Region: MarR_2; cl17246 471856006132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856006133 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471856006134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856006135 ABC transporter; Region: ABC_tran_2; pfam12848 471856006136 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856006137 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471856006138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856006139 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471856006140 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471856006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 471856006142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006143 G5 domain; Region: G5; pfam07501 471856006144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471856006145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471856006146 catalytic residue [active] 471856006147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 471856006148 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006149 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006150 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471856006151 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471856006152 catalytic residue [active] 471856006153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 471856006154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471856006157 G5 domain; Region: G5; pfam07501 471856006158 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471856006159 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471856006160 catalytic residue [active] 471856006161 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471856006162 active site 471856006163 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 471856006164 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471856006165 active site 471856006166 HIGH motif; other site 471856006167 KMSKS motif; other site 471856006168 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471856006169 anticodon binding site; other site 471856006170 tRNA binding surface [nucleotide binding]; other site 471856006171 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471856006172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 471856006173 Isochorismatase family; Region: Isochorismatase; pfam00857 471856006174 catalytic triad [active] 471856006175 conserved cis-peptide bond; other site 471856006176 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471856006177 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471856006178 putative ligand binding site [chemical binding]; other site 471856006179 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 471856006180 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856006181 dimerization interface [polypeptide binding]; other site 471856006182 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856006183 dimer interface [polypeptide binding]; other site 471856006184 putative CheW interface [polypeptide binding]; other site 471856006185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471856006186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471856006187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856006188 Walker A/P-loop; other site 471856006189 ATP binding site [chemical binding]; other site 471856006190 Q-loop/lid; other site 471856006191 ABC transporter signature motif; other site 471856006192 Walker B; other site 471856006193 D-loop; other site 471856006194 H-loop/switch region; other site 471856006195 Predicted methyltransferases [General function prediction only]; Region: COG0313 471856006196 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471856006197 putative SAM binding site [chemical binding]; other site 471856006198 putative homodimer interface [polypeptide binding]; other site 471856006199 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471856006200 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 471856006201 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 471856006202 NAD(P) binding site [chemical binding]; other site 471856006203 catalytic residues [active] 471856006204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471856006205 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471856006206 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471856006207 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471856006208 dimer interface [polypeptide binding]; other site 471856006209 putative functional site; other site 471856006210 putative MPT binding site; other site 471856006211 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471856006212 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 471856006213 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471856006214 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 471856006215 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471856006216 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 471856006217 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 471856006218 Holin family; Region: Phage_holin_4; pfam05105 471856006219 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 471856006220 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 471856006221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471856006222 Ligand Binding Site [chemical binding]; other site 471856006223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471856006224 Ligand Binding Site [chemical binding]; other site 471856006225 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471856006226 NlpC/P60 family; Region: NLPC_P60; pfam00877 471856006227 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471856006228 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471856006229 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471856006230 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 471856006231 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471856006232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856006233 catalytic residue [active] 471856006234 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856006235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856006236 putative substrate translocation pore; other site 471856006237 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471856006238 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856006239 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471856006240 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471856006241 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471856006242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471856006243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856006244 dimer interface [polypeptide binding]; other site 471856006245 putative CheW interface [polypeptide binding]; other site 471856006246 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471856006247 Response regulator receiver domain; Region: Response_reg; pfam00072 471856006248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006249 active site 471856006250 phosphorylation site [posttranslational modification] 471856006251 intermolecular recognition site; other site 471856006252 dimerization interface [polypeptide binding]; other site 471856006253 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 471856006254 Response regulator receiver domain; Region: Response_reg; pfam00072 471856006255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006256 active site 471856006257 phosphorylation site [posttranslational modification] 471856006258 intermolecular recognition site; other site 471856006259 dimerization interface [polypeptide binding]; other site 471856006260 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471856006261 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471856006262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856006263 S-adenosylmethionine binding site [chemical binding]; other site 471856006264 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 471856006265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006266 active site 471856006267 phosphorylation site [posttranslational modification] 471856006268 intermolecular recognition site; other site 471856006269 dimerization interface [polypeptide binding]; other site 471856006270 CheB methylesterase; Region: CheB_methylest; pfam01339 471856006271 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 471856006272 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471856006273 putative binding surface; other site 471856006274 active site 471856006275 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 471856006276 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 471856006277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856006278 ATP binding site [chemical binding]; other site 471856006279 Mg2+ binding site [ion binding]; other site 471856006280 G-X-G motif; other site 471856006281 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 471856006282 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 471856006283 Global regulator protein family; Region: CsrA; pfam02599 471856006284 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 471856006285 FHIPEP family; Region: FHIPEP; pfam00771 471856006286 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 471856006287 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 471856006288 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 471856006289 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 471856006290 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 471856006291 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 471856006292 flagellar motor switch protein FliN; Region: fliN; TIGR02480 471856006293 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 471856006294 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 471856006295 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 471856006296 flagellar motor protein MotD; Reviewed; Region: PRK09038 471856006297 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 471856006298 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471856006299 ligand binding site [chemical binding]; other site 471856006300 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 471856006301 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 471856006302 Flagellar protein (FlbD); Region: FlbD; pfam06289 471856006303 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 471856006304 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471856006305 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 471856006306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471856006307 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 471856006308 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 471856006309 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471856006310 NlpC/P60 family; Region: NLPC_P60; pfam00877 471856006311 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 471856006312 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 471856006313 Walker A motif/ATP binding site; other site 471856006314 Walker B motif; other site 471856006315 Flagellar assembly protein FliH; Region: FliH; pfam02108 471856006316 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 471856006317 FliG C-terminal domain; Region: FliG_C; pfam01706 471856006318 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 471856006319 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 471856006320 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 471856006321 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 471856006322 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 471856006323 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471856006324 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 471856006325 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 471856006326 Flagellar protein FliS; Region: FliS; cl00654 471856006327 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 471856006328 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 471856006329 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 471856006330 flagellin; Provisional; Region: PRK12804 471856006331 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471856006332 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471856006333 flagellin; Provisional; Region: PRK12804 471856006334 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471856006335 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471856006336 flagellin; Provisional; Region: PRK12804 471856006337 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471856006338 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471856006339 flagellin; Provisional; Region: PRK12804 471856006340 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471856006341 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471856006342 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 471856006343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856006344 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471856006345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471856006346 DNA binding residues [nucleotide binding] 471856006347 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 471856006348 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 471856006349 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 471856006350 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 471856006351 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471856006352 FliW protein; Region: FliW; cl00740 471856006353 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 471856006354 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471856006355 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471856006356 DNA-binding site [nucleotide binding]; DNA binding site 471856006357 RNA-binding motif; other site 471856006358 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471856006359 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471856006360 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471856006361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856006362 ATP binding site [chemical binding]; other site 471856006363 putative Mg++ binding site [ion binding]; other site 471856006364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856006365 nucleotide binding region [chemical binding]; other site 471856006366 ATP-binding site [chemical binding]; other site 471856006367 LabA_like proteins; Region: LabA_like; cd06167 471856006368 putative metal binding site [ion binding]; other site 471856006369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006371 active site 471856006372 phosphorylation site [posttranslational modification] 471856006373 intermolecular recognition site; other site 471856006374 dimerization interface [polypeptide binding]; other site 471856006375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856006376 DNA binding site [nucleotide binding] 471856006377 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471856006378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856006379 dimerization interface [polypeptide binding]; other site 471856006380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856006381 dimer interface [polypeptide binding]; other site 471856006382 phosphorylation site [posttranslational modification] 471856006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856006384 ATP binding site [chemical binding]; other site 471856006385 Mg2+ binding site [ion binding]; other site 471856006386 G-X-G motif; other site 471856006387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 471856006388 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471856006389 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471856006390 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471856006391 ring oligomerisation interface [polypeptide binding]; other site 471856006392 ATP/Mg binding site [chemical binding]; other site 471856006393 stacking interactions; other site 471856006394 hinge regions; other site 471856006395 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 471856006396 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471856006397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471856006398 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471856006399 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471856006400 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471856006401 active site 471856006402 catalytic triad [active] 471856006403 oxyanion hole [active] 471856006404 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471856006405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471856006406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471856006407 active site 471856006408 ATP binding site [chemical binding]; other site 471856006409 substrate binding site [chemical binding]; other site 471856006410 activation loop (A-loop); other site 471856006411 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 471856006412 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 471856006413 active site 471856006414 homotetramer interface [polypeptide binding]; other site 471856006415 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 471856006416 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 471856006417 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471856006418 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471856006419 Walker A/P-loop; other site 471856006420 ATP binding site [chemical binding]; other site 471856006421 Q-loop/lid; other site 471856006422 ABC transporter signature motif; other site 471856006423 Walker B; other site 471856006424 D-loop; other site 471856006425 H-loop/switch region; other site 471856006426 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 471856006427 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 471856006428 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471856006429 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471856006430 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471856006431 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471856006432 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471856006433 active site 471856006434 HIGH motif; other site 471856006435 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471856006436 KMSKS motif; other site 471856006437 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471856006438 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471856006439 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471856006440 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471856006441 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856006442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006443 dimer interface [polypeptide binding]; other site 471856006444 conserved gate region; other site 471856006445 putative PBP binding loops; other site 471856006446 ABC-ATPase subunit interface; other site 471856006447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006448 dimer interface [polypeptide binding]; other site 471856006449 conserved gate region; other site 471856006450 putative PBP binding loops; other site 471856006451 ABC-ATPase subunit interface; other site 471856006452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856006453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856006454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856006455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856006456 DNA binding site [nucleotide binding] 471856006457 domain linker motif; other site 471856006458 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471856006459 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471856006460 homotrimer interaction site [polypeptide binding]; other site 471856006461 zinc binding site [ion binding]; other site 471856006462 CDP-binding sites; other site 471856006463 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471856006464 substrate binding site; other site 471856006465 dimer interface; other site 471856006466 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 471856006467 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471856006468 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 471856006469 Walker A/P-loop; other site 471856006470 ATP binding site [chemical binding]; other site 471856006471 Q-loop/lid; other site 471856006472 ABC transporter signature motif; other site 471856006473 Walker B; other site 471856006474 D-loop; other site 471856006475 H-loop/switch region; other site 471856006476 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 471856006477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006478 dimer interface [polypeptide binding]; other site 471856006479 conserved gate region; other site 471856006480 putative PBP binding loops; other site 471856006481 ABC-ATPase subunit interface; other site 471856006482 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 471856006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006484 dimer interface [polypeptide binding]; other site 471856006485 conserved gate region; other site 471856006486 putative PBP binding loops; other site 471856006487 ABC-ATPase subunit interface; other site 471856006488 PBP superfamily domain; Region: PBP_like_2; cl17296 471856006489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856006490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006491 active site 471856006492 phosphorylation site [posttranslational modification] 471856006493 intermolecular recognition site; other site 471856006494 dimerization interface [polypeptide binding]; other site 471856006495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856006496 DNA binding site [nucleotide binding] 471856006497 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471856006498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856006499 dimer interface [polypeptide binding]; other site 471856006500 phosphorylation site [posttranslational modification] 471856006501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856006502 ATP binding site [chemical binding]; other site 471856006503 Mg2+ binding site [ion binding]; other site 471856006504 G-X-G motif; other site 471856006505 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471856006506 PhoU domain; Region: PhoU; pfam01895 471856006507 PhoU domain; Region: PhoU; pfam01895 471856006508 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471856006509 catalytic core [active] 471856006510 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 471856006511 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471856006512 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 471856006513 putative ADP-binding pocket [chemical binding]; other site 471856006514 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471856006515 Lsr2; Region: Lsr2; pfam11774 471856006516 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471856006517 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471856006518 dimer interface [polypeptide binding]; other site 471856006519 putative anticodon binding site; other site 471856006520 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471856006521 motif 1; other site 471856006522 dimer interface [polypeptide binding]; other site 471856006523 active site 471856006524 motif 2; other site 471856006525 motif 3; other site 471856006526 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 471856006527 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471856006528 dimerization interface [polypeptide binding]; other site 471856006529 active site 471856006530 L-aspartate oxidase; Provisional; Region: PRK07804 471856006531 L-aspartate oxidase; Provisional; Region: PRK06175 471856006532 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471856006533 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471856006534 tetramerization interface [polypeptide binding]; other site 471856006535 active site 471856006536 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 471856006537 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471856006538 active site 471856006539 nucleotide binding site [chemical binding]; other site 471856006540 HIGH motif; other site 471856006541 KMSKS motif; other site 471856006542 Rossmann-like domain; Region: Rossmann-like; pfam10727 471856006543 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471856006544 Bacterial PH domain; Region: DUF304; pfam03703 471856006545 Bacterial PH domain; Region: DUF304; cl01348 471856006546 Bacterial PH domain; Region: DUF304; pfam03703 471856006547 Uncharacterized conserved protein [Function unknown]; Region: COG3402 471856006548 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 471856006549 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471856006550 homooctamer interface [polypeptide binding]; other site 471856006551 active site 471856006552 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471856006553 catalytic center binding site [active] 471856006554 ATP binding site [chemical binding]; other site 471856006555 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471856006556 dihydropteroate synthase; Region: DHPS; TIGR01496 471856006557 substrate binding pocket [chemical binding]; other site 471856006558 dimer interface [polypeptide binding]; other site 471856006559 inhibitor binding site; inhibition site 471856006560 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471856006561 homodecamer interface [polypeptide binding]; other site 471856006562 GTP cyclohydrolase I; Provisional; Region: PLN03044 471856006563 active site 471856006564 putative catalytic site residues [active] 471856006565 zinc binding site [ion binding]; other site 471856006566 GTP-CH-I/GFRP interaction surface; other site 471856006567 FtsH Extracellular; Region: FtsH_ext; pfam06480 471856006568 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471856006569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856006570 Walker A motif; other site 471856006571 ATP binding site [chemical binding]; other site 471856006572 Walker B motif; other site 471856006573 arginine finger; other site 471856006574 Peptidase family M41; Region: Peptidase_M41; pfam01434 471856006575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856006576 active site 471856006577 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471856006578 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471856006579 Ligand Binding Site [chemical binding]; other site 471856006580 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 471856006581 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 471856006582 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471856006583 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 471856006584 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471856006585 dimer interface [polypeptide binding]; other site 471856006586 substrate binding site [chemical binding]; other site 471856006587 metal binding sites [ion binding]; metal-binding site 471856006588 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471856006589 NlpC/P60 family; Region: NLPC_P60; pfam00877 471856006590 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471856006591 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471856006592 homodimer interface [polypeptide binding]; other site 471856006593 substrate-cofactor binding pocket; other site 471856006594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856006595 catalytic residue [active] 471856006596 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 471856006597 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 471856006598 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471856006599 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471856006600 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471856006601 NAD(P) binding site [chemical binding]; other site 471856006602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856006603 PGAP1-like protein; Region: PGAP1; pfam07819 471856006604 Domain of unknown function DUF77; Region: DUF77; pfam01910 471856006605 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471856006606 FAD binding domain; Region: FAD_binding_4; pfam01565 471856006607 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471856006608 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 471856006609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471856006610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471856006611 Walker A/P-loop; other site 471856006612 ATP binding site [chemical binding]; other site 471856006613 Q-loop/lid; other site 471856006614 ABC transporter signature motif; other site 471856006615 Walker B; other site 471856006616 D-loop; other site 471856006617 H-loop/switch region; other site 471856006618 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471856006619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471856006620 FtsX-like permease family; Region: FtsX; pfam02687 471856006621 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471856006622 FtsX-like permease family; Region: FtsX; pfam02687 471856006623 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 471856006624 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471856006625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471856006626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 471856006627 YceI-like domain; Region: YceI; pfam04264 471856006628 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 471856006629 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 471856006630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856006631 active site 471856006632 DNA binding site [nucleotide binding] 471856006633 Int/Topo IB signature motif; other site 471856006634 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471856006635 Helix-turn-helix; Region: HTH_3; pfam01381 471856006636 non-specific DNA binding site [nucleotide binding]; other site 471856006637 salt bridge; other site 471856006638 sequence-specific DNA binding site [nucleotide binding]; other site 471856006639 Helix-turn-helix; Region: HTH_3; pfam01381 471856006640 sequence-specific DNA binding site [nucleotide binding]; other site 471856006641 salt bridge; other site 471856006642 Prophage antirepressor [Transcription]; Region: COG3617 471856006643 BRO family, N-terminal domain; Region: Bro-N; smart01040 471856006644 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 471856006645 Helix-turn-helix domain; Region: HTH_17; pfam12728 471856006646 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 471856006647 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471856006648 catalytic residues [active] 471856006649 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471856006650 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471856006651 ssDNA binding site [nucleotide binding]; other site 471856006652 dimer interface [polypeptide binding]; other site 471856006653 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471856006654 Endodeoxyribonuclease RusA; Region: RusA; cl01885 471856006655 Transcription factor WhiB; Region: Whib; pfam02467 471856006656 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471856006657 DNA-binding interface [nucleotide binding]; DNA binding site 471856006658 replicative DNA helicase; Region: DnaB; TIGR00665 471856006659 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471856006660 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471856006661 Walker A motif; other site 471856006662 ATP binding site [chemical binding]; other site 471856006663 Walker B motif; other site 471856006664 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 471856006665 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 471856006666 active site 471856006667 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 471856006668 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471856006669 active site 471856006670 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 471856006671 Phage terminase, small subunit; Region: Terminase_4; cl01525 471856006672 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 471856006673 Phage capsid family; Region: Phage_capsid; pfam05065 471856006674 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 471856006675 Putative phage tail protein; Region: Phage-tail_3; pfam13550 471856006676 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471856006677 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471856006678 TAP-like protein; Region: Abhydrolase_4; pfam08386 471856006679 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471856006680 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471856006681 thymidylate kinase; Validated; Region: tmk; PRK00698 471856006682 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471856006683 TMP-binding site; other site 471856006684 ATP-binding site [chemical binding]; other site 471856006685 putative phosphatase; Provisional; Region: PRK11587 471856006686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856006687 motif II; other site 471856006688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471856006689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471856006690 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471856006691 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471856006692 active site 471856006693 interdomain interaction site; other site 471856006694 putative metal-binding site [ion binding]; other site 471856006695 nucleotide binding site [chemical binding]; other site 471856006696 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 471856006697 domain I; other site 471856006698 phosphate binding site [ion binding]; other site 471856006699 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471856006700 domain II; other site 471856006701 domain III; other site 471856006702 nucleotide binding site [chemical binding]; other site 471856006703 DNA binding groove [nucleotide binding] 471856006704 catalytic site [active] 471856006705 domain IV; other site 471856006706 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471856006707 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471856006708 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471856006709 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471856006710 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471856006711 active site 471856006712 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 471856006713 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471856006714 active site 471856006715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 471856006716 DNA binding site [nucleotide binding] 471856006717 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471856006718 active site 471856006719 SAM binding site [chemical binding]; other site 471856006720 homodimer interface [polypeptide binding]; other site 471856006721 nitrite reductase subunit NirD; Provisional; Region: PRK14989 471856006722 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471856006723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471856006724 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471856006725 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 471856006726 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471856006727 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471856006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856006729 S-adenosylmethionine binding site [chemical binding]; other site 471856006730 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471856006731 putative catalytic site [active] 471856006732 putative metal binding site [ion binding]; other site 471856006733 putative catalytic site [active] 471856006734 putative phosphate binding site [ion binding]; other site 471856006735 putative metal binding site [ion binding]; other site 471856006736 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 471856006737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471856006738 FeS/SAM binding site; other site 471856006739 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 471856006740 Class III ribonucleotide reductase; Region: RNR_III; cd01675 471856006741 effector binding site; other site 471856006742 active site 471856006743 Zn binding site [ion binding]; other site 471856006744 glycine loop; other site 471856006745 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471856006746 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471856006747 substrate binding site [chemical binding]; other site 471856006748 ATP binding site [chemical binding]; other site 471856006749 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 471856006750 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471856006751 active site 471856006752 intersubunit interface [polypeptide binding]; other site 471856006753 catalytic residue [active] 471856006754 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471856006755 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471856006756 Bacterial transcriptional regulator; Region: IclR; pfam01614 471856006757 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471856006758 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471856006759 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471856006760 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471856006761 dimer interface [polypeptide binding]; other site 471856006762 active site 471856006763 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471856006764 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856006765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471856006766 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471856006767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856006768 Coenzyme A binding pocket [chemical binding]; other site 471856006769 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471856006770 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471856006771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856006772 ATP binding site [chemical binding]; other site 471856006773 putative Mg++ binding site [ion binding]; other site 471856006774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471856006775 nucleotide binding region [chemical binding]; other site 471856006776 ATP-binding site [chemical binding]; other site 471856006777 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471856006778 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 471856006779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471856006780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856006781 catalytic residue [active] 471856006782 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 471856006783 Type II/IV secretion system protein; Region: T2SE; pfam00437 471856006784 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471856006785 ATP binding site [chemical binding]; other site 471856006786 Walker A motif; other site 471856006787 hexamer interface [polypeptide binding]; other site 471856006788 Walker B motif; other site 471856006789 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471856006790 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471856006791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856006792 motif II; other site 471856006793 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 471856006794 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471856006795 Cellulose or protein binding domain; Region: CBM_10; pfam02013 471856006796 Cellulose or protein binding domain; Region: CBM_10; smart01064 471856006797 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471856006798 Cellulose binding domain; Region: CBM_2; pfam00553 471856006799 acetyl-CoA synthetase; Provisional; Region: PRK00174 471856006800 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 471856006801 active site 471856006802 CoA binding site [chemical binding]; other site 471856006803 acyl-activating enzyme (AAE) consensus motif; other site 471856006804 AMP binding site [chemical binding]; other site 471856006805 acetate binding site [chemical binding]; other site 471856006806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856006807 dimer interface [polypeptide binding]; other site 471856006808 putative CheW interface [polypeptide binding]; other site 471856006809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471856006810 PAS fold; Region: PAS_3; pfam08447 471856006811 putative active site [active] 471856006812 heme pocket [chemical binding]; other site 471856006813 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471856006814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856006815 Coenzyme A binding pocket [chemical binding]; other site 471856006816 polyphosphate kinase; Provisional; Region: PRK05443 471856006817 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471856006818 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471856006819 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471856006820 putative domain interface [polypeptide binding]; other site 471856006821 putative active site [active] 471856006822 catalytic site [active] 471856006823 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471856006824 putative domain interface [polypeptide binding]; other site 471856006825 putative active site [active] 471856006826 catalytic site [active] 471856006827 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471856006828 active site 471856006829 Ap6A binding site [chemical binding]; other site 471856006830 nudix motif; other site 471856006831 metal binding site [ion binding]; metal-binding site 471856006832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471856006833 catalytic core [active] 471856006834 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471856006835 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471856006836 SelR domain; Region: SelR; pfam01641 471856006837 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 471856006838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006839 dimer interface [polypeptide binding]; other site 471856006840 conserved gate region; other site 471856006841 putative PBP binding loops; other site 471856006842 ABC-ATPase subunit interface; other site 471856006843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856006844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856006845 dimer interface [polypeptide binding]; other site 471856006846 conserved gate region; other site 471856006847 putative PBP binding loops; other site 471856006848 ABC-ATPase subunit interface; other site 471856006849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856006850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471856006851 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471856006852 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471856006853 active site 471856006854 catalytic site [active] 471856006855 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471856006856 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471856006857 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471856006858 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471856006859 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471856006860 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 471856006861 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471856006862 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471856006863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471856006864 ATP binding site [chemical binding]; other site 471856006865 putative Mg++ binding site [ion binding]; other site 471856006866 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471856006867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856006868 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471856006869 Walker A motif; other site 471856006870 ATP binding site [chemical binding]; other site 471856006871 Walker B motif; other site 471856006872 arginine finger; other site 471856006873 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471856006874 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471856006875 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471856006876 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471856006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856006878 Walker A/P-loop; other site 471856006879 ATP binding site [chemical binding]; other site 471856006880 Q-loop/lid; other site 471856006881 ABC transporter signature motif; other site 471856006882 Walker B; other site 471856006883 D-loop; other site 471856006884 H-loop/switch region; other site 471856006885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856006886 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 471856006887 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471856006888 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471856006889 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471856006890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471856006891 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 471856006892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856006893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856006894 putative Zn2+ binding site [ion binding]; other site 471856006895 putative DNA binding site [nucleotide binding]; other site 471856006896 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 471856006897 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 471856006898 ligand binding site [chemical binding]; other site 471856006899 homodimer interface [polypeptide binding]; other site 471856006900 NAD(P) binding site [chemical binding]; other site 471856006901 trimer interface B [polypeptide binding]; other site 471856006902 trimer interface A [polypeptide binding]; other site 471856006903 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471856006904 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 471856006905 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 471856006906 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471856006907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856006908 NAD(P) binding site [chemical binding]; other site 471856006909 active site 471856006910 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 471856006911 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471856006912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856006913 non-specific DNA binding site [nucleotide binding]; other site 471856006914 salt bridge; other site 471856006915 sequence-specific DNA binding site [nucleotide binding]; other site 471856006916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471856006917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471856006918 non-specific DNA binding site [nucleotide binding]; other site 471856006919 salt bridge; other site 471856006920 sequence-specific DNA binding site [nucleotide binding]; other site 471856006921 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 471856006922 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 471856006923 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 471856006924 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471856006925 catalytic residues [active] 471856006926 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471856006927 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471856006928 ssDNA binding site [nucleotide binding]; other site 471856006929 dimer interface [polypeptide binding]; other site 471856006930 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471856006931 Endodeoxyribonuclease RusA; Region: RusA; cl01885 471856006932 Transcription factor WhiB; Region: Whib; pfam02467 471856006933 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471856006934 DNA-binding interface [nucleotide binding]; DNA binding site 471856006935 replicative DNA helicase; Region: DnaB; TIGR00665 471856006936 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471856006937 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471856006938 Walker A motif; other site 471856006939 ATP binding site [chemical binding]; other site 471856006940 Walker B motif; other site 471856006941 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 471856006942 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 471856006943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471856006944 active site 471856006945 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 471856006946 Phage capsid family; Region: Phage_capsid; pfam05065 471856006947 tape measure domain; Region: tape_meas_nterm; TIGR02675 471856006948 Phage-related protein [Function unknown]; Region: COG5412 471856006949 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471856006950 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471856006951 Right handed beta helix region; Region: Beta_helix; pfam13229 471856006952 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 471856006953 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471856006954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856006955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471856006956 active site 471856006957 DNA binding site [nucleotide binding] 471856006958 Int/Topo IB signature motif; other site 471856006959 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471856006960 metal-binding site [ion binding] 471856006961 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471856006962 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856006963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856006964 motif II; other site 471856006965 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 471856006966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471856006967 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471856006968 dimerization interface [polypeptide binding]; other site 471856006969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471856006970 dimer interface [polypeptide binding]; other site 471856006971 phosphorylation site [posttranslational modification] 471856006972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856006973 ATP binding site [chemical binding]; other site 471856006974 Mg2+ binding site [ion binding]; other site 471856006975 G-X-G motif; other site 471856006976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471856006977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856006978 active site 471856006979 phosphorylation site [posttranslational modification] 471856006980 intermolecular recognition site; other site 471856006981 dimerization interface [polypeptide binding]; other site 471856006982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471856006983 DNA binding site [nucleotide binding] 471856006984 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 471856006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 471856006986 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 471856006987 Phosphotransferase enzyme family; Region: APH; pfam01636 471856006988 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471856006989 DNA binding residues [nucleotide binding] 471856006990 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471856006991 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471856006992 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471856006993 dimerization interface [polypeptide binding]; other site 471856006994 putative ATP binding site [chemical binding]; other site 471856006995 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471856006996 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471856006997 active site 471856006998 tetramer interface [polypeptide binding]; other site 471856006999 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856007000 active site 471856007001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471856007002 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471856007003 sulfate transport protein; Provisional; Region: cysT; CHL00187 471856007004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856007005 dimer interface [polypeptide binding]; other site 471856007006 conserved gate region; other site 471856007007 putative PBP binding loops; other site 471856007008 ABC-ATPase subunit interface; other site 471856007009 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471856007010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856007011 dimer interface [polypeptide binding]; other site 471856007012 conserved gate region; other site 471856007013 putative PBP binding loops; other site 471856007014 ABC-ATPase subunit interface; other site 471856007015 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 471856007016 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 471856007017 Walker A/P-loop; other site 471856007018 ATP binding site [chemical binding]; other site 471856007019 Q-loop/lid; other site 471856007020 ABC transporter signature motif; other site 471856007021 Walker B; other site 471856007022 D-loop; other site 471856007023 H-loop/switch region; other site 471856007024 TOBE-like domain; Region: TOBE_3; pfam12857 471856007025 glutamate dehydrogenase; Provisional; Region: PRK09414 471856007026 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471856007027 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471856007028 NAD(P) binding site [chemical binding]; other site 471856007029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471856007030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856007031 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471856007032 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471856007033 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471856007034 [4Fe-4S] binding site [ion binding]; other site 471856007035 molybdopterin cofactor binding site; other site 471856007036 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 471856007037 molybdopterin cofactor binding site; other site 471856007038 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 471856007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 471856007040 putative substrate translocation pore; other site 471856007041 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 471856007042 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471856007043 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471856007044 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471856007045 dimerization interface [polypeptide binding]; other site 471856007046 ATP binding site [chemical binding]; other site 471856007047 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471856007048 dimerization interface [polypeptide binding]; other site 471856007049 ATP binding site [chemical binding]; other site 471856007050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471856007051 RNA binding site [nucleotide binding]; other site 471856007052 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 471856007053 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 471856007054 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 471856007055 putative ligand binding residues [chemical binding]; other site 471856007056 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471856007057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856007058 ABC-ATPase subunit interface; other site 471856007059 dimer interface [polypeptide binding]; other site 471856007060 putative PBP binding regions; other site 471856007061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471856007062 ABC-ATPase subunit interface; other site 471856007063 dimer interface [polypeptide binding]; other site 471856007064 putative PBP binding regions; other site 471856007065 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 471856007066 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471856007067 Walker A/P-loop; other site 471856007068 ATP binding site [chemical binding]; other site 471856007069 Q-loop/lid; other site 471856007070 ABC transporter signature motif; other site 471856007071 Walker B; other site 471856007072 D-loop; other site 471856007073 H-loop/switch region; other site 471856007074 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471856007075 Domain of unknown function DUF21; Region: DUF21; pfam01595 471856007076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856007077 Domain of unknown function DUF21; Region: DUF21; pfam01595 471856007078 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471856007079 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471856007080 Transporter associated domain; Region: CorC_HlyC; pfam03471 471856007081 Predicted membrane protein [Function unknown]; Region: COG4270 471856007082 acyl-coenzyme A oxidase; Region: PLN02636 471856007083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471856007084 active site 471856007085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856007086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856007087 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 471856007088 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471856007089 dimer interface [polypeptide binding]; other site 471856007090 active site 471856007091 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 471856007092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471856007093 NAD(P) binding site [chemical binding]; other site 471856007094 active site 471856007095 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471856007096 active site 2 [active] 471856007097 active site 1 [active] 471856007098 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471856007099 active site 2 [active] 471856007100 active site 1 [active] 471856007101 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 471856007102 Cellulose binding domain; Region: CBM_2; cl17741 471856007103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471856007104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471856007105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471856007106 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 471856007107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856007108 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471856007109 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 471856007110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856007111 S-adenosylmethionine binding site [chemical binding]; other site 471856007112 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471856007113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471856007114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471856007115 catalytic residue [active] 471856007116 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471856007117 active site residue [active] 471856007118 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 471856007119 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471856007120 homodimer interface [polypeptide binding]; other site 471856007121 substrate-cofactor binding pocket; other site 471856007122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007123 catalytic residue [active] 471856007124 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 471856007125 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 471856007126 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471856007127 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471856007128 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471856007129 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471856007130 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 471856007131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471856007132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471856007133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471856007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856007135 dimer interface [polypeptide binding]; other site 471856007136 ABC-ATPase subunit interface; other site 471856007137 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471856007138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471856007139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471856007140 dimer interface [polypeptide binding]; other site 471856007141 ABC-ATPase subunit interface; other site 471856007142 putative PBP binding loops; other site 471856007143 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 471856007144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856007145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856007146 DNA binding site [nucleotide binding] 471856007147 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856007148 dimerization interface [polypeptide binding]; other site 471856007149 ligand binding site [chemical binding]; other site 471856007150 glucuronate isomerase; Reviewed; Region: PRK02925 471856007151 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 471856007152 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471856007153 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471856007154 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471856007155 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471856007156 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471856007157 metal binding site [ion binding]; metal-binding site 471856007158 substrate binding pocket [chemical binding]; other site 471856007159 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471856007160 AAA domain; Region: AAA_33; pfam13671 471856007161 ATP-binding site [chemical binding]; other site 471856007162 Gluconate-6-phosphate binding site [chemical binding]; other site 471856007163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471856007164 Coenzyme A binding pocket [chemical binding]; other site 471856007165 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 471856007166 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471856007167 putative active site [active] 471856007168 catalytic triad [active] 471856007169 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 471856007170 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471856007171 ATP binding site [chemical binding]; other site 471856007172 active site 471856007173 substrate binding site [chemical binding]; other site 471856007174 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471856007175 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471856007176 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471856007177 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471856007178 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471856007179 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471856007180 putative di-iron ligands [ion binding]; other site 471856007181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856007182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856007183 DNA binding site [nucleotide binding] 471856007184 domain linker motif; other site 471856007185 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471856007186 dimerization interface [polypeptide binding]; other site 471856007187 ligand binding site [chemical binding]; other site 471856007188 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471856007189 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471856007190 GDP-binding site [chemical binding]; other site 471856007191 ACT binding site; other site 471856007192 IMP binding site; other site 471856007193 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471856007194 anti sigma factor interaction site; other site 471856007195 regulatory phosphorylation site [posttranslational modification]; other site 471856007196 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471856007197 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471856007198 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471856007199 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471856007200 anti sigma factor interaction site; other site 471856007201 regulatory phosphorylation site [posttranslational modification]; other site 471856007202 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471856007203 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 471856007204 active site 471856007205 intersubunit interface [polypeptide binding]; other site 471856007206 zinc binding site [ion binding]; other site 471856007207 Na+ binding site [ion binding]; other site 471856007208 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 471856007209 UMP phosphatase; Provisional; Region: PRK10444 471856007210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856007211 active site 471856007212 motif I; other site 471856007213 motif II; other site 471856007214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856007215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471856007216 active site 471856007217 short chain dehydrogenase; Provisional; Region: PRK08251 471856007218 classical (c) SDRs; Region: SDR_c; cd05233 471856007219 NAD(P) binding site [chemical binding]; other site 471856007220 active site 471856007221 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471856007222 putative catalytic site [active] 471856007223 putative phosphate binding site [ion binding]; other site 471856007224 active site 471856007225 metal binding site A [ion binding]; metal-binding site 471856007226 DNA binding site [nucleotide binding] 471856007227 putative AP binding site [nucleotide binding]; other site 471856007228 putative metal binding site B [ion binding]; other site 471856007229 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471856007230 NlpC/P60 family; Region: NLPC_P60; pfam00877 471856007231 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471856007232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856007233 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471856007234 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471856007235 Clp amino terminal domain; Region: Clp_N; pfam02861 471856007236 Clp amino terminal domain; Region: Clp_N; pfam02861 471856007237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856007238 Walker A motif; other site 471856007239 ATP binding site [chemical binding]; other site 471856007240 Walker B motif; other site 471856007241 arginine finger; other site 471856007242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471856007243 Walker A motif; other site 471856007244 ATP binding site [chemical binding]; other site 471856007245 Walker B motif; other site 471856007246 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471856007247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856007248 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471856007249 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 471856007250 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 471856007251 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 471856007252 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 471856007253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856007254 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 471856007255 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 471856007256 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471856007257 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 471856007258 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471856007259 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471856007260 trimer interface [polypeptide binding]; other site 471856007261 active site 471856007262 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 471856007263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856007264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856007265 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471856007266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471856007267 motif II; other site 471856007268 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471856007269 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471856007270 Chitin binding domain; Region: Chitin_bind_3; pfam03067 471856007271 CBD_II domain; Region: CBD_II; smart00637 471856007272 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 471856007273 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 471856007274 MoxR-like ATPases [General function prediction only]; Region: COG0714 471856007275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471856007276 Protein of unknown function DUF58; Region: DUF58; pfam01882 471856007277 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471856007278 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471856007279 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471856007280 metal ion-dependent adhesion site (MIDAS); other site 471856007281 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471856007282 metal ion-dependent adhesion site (MIDAS); other site 471856007283 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 471856007284 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471856007285 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 471856007286 RNase_H superfamily; Region: RNase_H_2; pfam13482 471856007287 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 471856007288 AAA domain; Region: AAA_30; pfam13604 471856007289 AAA domain; Region: AAA_12; pfam13087 471856007290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856007291 Walker A/P-loop; other site 471856007292 ATP binding site [chemical binding]; other site 471856007293 Q-loop/lid; other site 471856007294 ABC transporter signature motif; other site 471856007295 Walker B; other site 471856007296 D-loop; other site 471856007297 H-loop/switch region; other site 471856007298 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471856007299 FAD binding domain; Region: FAD_binding_4; pfam01565 471856007300 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471856007301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471856007302 binding surface 471856007303 TPR motif; other site 471856007304 HSP90 family protein; Provisional; Region: PRK14083 471856007305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471856007306 dimerization interface [polypeptide binding]; other site 471856007307 putative DNA binding site [nucleotide binding]; other site 471856007308 putative Zn2+ binding site [ion binding]; other site 471856007309 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471856007310 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471856007311 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471856007312 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471856007313 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471856007314 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471856007315 E3 interaction surface; other site 471856007316 lipoyl attachment site [posttranslational modification]; other site 471856007317 e3 binding domain; Region: E3_binding; pfam02817 471856007318 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471856007319 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471856007320 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471856007321 alpha subunit interface [polypeptide binding]; other site 471856007322 TPP binding site [chemical binding]; other site 471856007323 heterodimer interface [polypeptide binding]; other site 471856007324 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471856007325 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471856007326 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471856007327 tetramer interface [polypeptide binding]; other site 471856007328 TPP-binding site [chemical binding]; other site 471856007329 heterodimer interface [polypeptide binding]; other site 471856007330 phosphorylation loop region [posttranslational modification] 471856007331 Membrane protein of unknown function; Region: DUF360; pfam04020 471856007332 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 471856007333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007335 homodimer interface [polypeptide binding]; other site 471856007336 catalytic residue [active] 471856007337 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 471856007338 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471856007339 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 471856007340 GAF domain; Region: GAF_2; pfam13185 471856007341 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471856007342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471856007343 dimer interface [polypeptide binding]; other site 471856007344 putative CheW interface [polypeptide binding]; other site 471856007345 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471856007346 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471856007347 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471856007348 adenylosuccinate lyase; Provisional; Region: PRK09285 471856007349 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 471856007350 tetramer interface [polypeptide binding]; other site 471856007351 active site 471856007352 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471856007353 catalytic residues [active] 471856007354 dimer interface [polypeptide binding]; other site 471856007355 Melibiase; Region: Melibiase; pfam02065 471856007356 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471856007357 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471856007358 DNA binding site [nucleotide binding] 471856007359 domain linker motif; other site 471856007360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471856007361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471856007362 YwiC-like protein; Region: YwiC; pfam14256 471856007363 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471856007364 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 471856007365 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471856007366 substrate binding site [chemical binding]; other site 471856007367 active site 471856007368 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471856007369 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471856007370 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471856007371 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471856007372 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471856007373 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471856007374 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 471856007375 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471856007376 active site 471856007377 domain interfaces; other site 471856007378 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 471856007379 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471856007380 active site 471856007381 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 471856007382 dimer interface [polypeptide binding]; other site 471856007383 active site 471856007384 Schiff base residues; other site 471856007385 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471856007386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471856007387 inhibitor-cofactor binding pocket; inhibition site 471856007388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007389 catalytic residue [active] 471856007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471856007391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856007392 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471856007393 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471856007394 putative homotetramer interface [polypeptide binding]; other site 471856007395 putative homodimer interface [polypeptide binding]; other site 471856007396 putative allosteric switch controlling residues; other site 471856007397 putative metal binding site [ion binding]; other site 471856007398 putative homodimer-homodimer interface [polypeptide binding]; other site 471856007399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471856007400 metal-binding site [ion binding] 471856007401 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471856007402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471856007403 metal-binding site [ion binding] 471856007404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471856007405 CopC domain; Region: CopC; pfam04234 471856007406 CAAX protease self-immunity; Region: Abi; pfam02517 471856007407 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 471856007408 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471856007409 YibE/F-like protein; Region: YibE_F; pfam07907 471856007410 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471856007411 IHF dimer interface [polypeptide binding]; other site 471856007412 IHF - DNA interface [nucleotide binding]; other site 471856007413 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 471856007414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856007415 S-adenosylmethionine binding site [chemical binding]; other site 471856007416 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471856007417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856007418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007419 homodimer interface [polypeptide binding]; other site 471856007420 catalytic residue [active] 471856007421 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471856007422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471856007423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856007424 Walker A/P-loop; other site 471856007425 ATP binding site [chemical binding]; other site 471856007426 Q-loop/lid; other site 471856007427 ABC transporter signature motif; other site 471856007428 Walker B; other site 471856007429 D-loop; other site 471856007430 H-loop/switch region; other site 471856007431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471856007432 Histidine kinase; Region: HisKA_3; pfam07730 471856007433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471856007434 ATP binding site [chemical binding]; other site 471856007435 Mg2+ binding site [ion binding]; other site 471856007436 G-X-G motif; other site 471856007437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471856007438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471856007439 active site 471856007440 phosphorylation site [posttranslational modification] 471856007441 intermolecular recognition site; other site 471856007442 dimerization interface [polypeptide binding]; other site 471856007443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471856007444 DNA binding residues [nucleotide binding] 471856007445 dimerization interface [polypeptide binding]; other site 471856007446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471856007447 MarR family; Region: MarR; pfam01047 471856007448 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471856007449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471856007450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471856007451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 471856007452 putative acyl-acceptor binding pocket; other site 471856007453 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471856007454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471856007455 replicative DNA helicase; Region: DnaB; TIGR00665 471856007456 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471856007457 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471856007458 Walker A motif; other site 471856007459 ATP binding site [chemical binding]; other site 471856007460 Walker B motif; other site 471856007461 DNA binding loops [nucleotide binding] 471856007462 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 471856007463 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471856007464 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471856007465 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471856007466 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471856007467 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471856007468 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471856007469 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471856007470 dimer interface [polypeptide binding]; other site 471856007471 ssDNA binding site [nucleotide binding]; other site 471856007472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471856007473 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471856007474 Transglycosylase; Region: Transgly; pfam00912 471856007475 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471856007476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471856007477 Predicted transcriptional regulators [Transcription]; Region: COG1695 471856007478 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471856007479 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 471856007480 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 471856007481 H+ Antiporter protein; Region: 2A0121; TIGR00900 471856007482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471856007483 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471856007484 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 471856007485 putative active site [active] 471856007486 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 471856007487 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471856007488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471856007489 UDP-galactopyranose mutase; Region: GLF; pfam03275 471856007490 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471856007491 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471856007492 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471856007493 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471856007494 putative glycosyl transferase; Provisional; Region: PRK10073 471856007495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471856007496 active site 471856007497 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 471856007498 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471856007499 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471856007500 catalytic residue [active] 471856007501 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 471856007502 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471856007503 dimer interface [polypeptide binding]; other site 471856007504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007505 catalytic residue [active] 471856007506 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471856007507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471856007508 Walker A/P-loop; other site 471856007509 ATP binding site [chemical binding]; other site 471856007510 Q-loop/lid; other site 471856007511 ABC transporter signature motif; other site 471856007512 Walker B; other site 471856007513 D-loop; other site 471856007514 H-loop/switch region; other site 471856007515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471856007516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471856007517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471856007518 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471856007519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471856007520 active site 471856007521 NTP binding site [chemical binding]; other site 471856007522 metal binding triad [ion binding]; metal-binding site 471856007523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471856007524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471856007525 Zn2+ binding site [ion binding]; other site 471856007526 Mg2+ binding site [ion binding]; other site 471856007527 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 471856007528 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471856007529 active site 471856007530 Ap6A binding site [chemical binding]; other site 471856007531 nudix motif; other site 471856007532 metal binding site [ion binding]; metal-binding site 471856007533 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471856007534 MviN-like protein; Region: MVIN; pfam03023 471856007535 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471856007536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471856007537 active site 471856007538 ATP binding site [chemical binding]; other site 471856007539 substrate binding site [chemical binding]; other site 471856007540 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471856007541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471856007542 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471856007543 catalytic residues [active] 471856007544 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471856007545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471856007546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471856007547 homodimer interface [polypeptide binding]; other site 471856007548 catalytic residue [active] 471856007549 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471856007550 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471856007551 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471856007552 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471856007553 ParB-like nuclease domain; Region: ParBc; pfam02195 471856007554 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471856007555 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856007556 P-loop; other site 471856007557 Magnesium ion binding site [ion binding]; other site 471856007558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471856007559 Magnesium ion binding site [ion binding]; other site 471856007560 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 471856007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471856007562 S-adenosylmethionine binding site [chemical binding]; other site 471856007563 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 471856007564 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471856007565 G-X-X-G motif; other site 471856007566 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471856007567 RxxxH motif; other site 471856007568 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 471856007569 Haemolytic domain; Region: Haemolytic; pfam01809 471856007570 Ribonuclease P; Region: Ribonuclease_P; pfam00825 471856007571 Ribosomal protein L34; Region: Ribosomal_L34; cl00370