-- dump date 20140619_120422 -- class Genbank::misc_feature -- table misc_feature_note -- id note 523791000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 523791000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 523791000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791000004 Walker A motif; other site 523791000005 ATP binding site [chemical binding]; other site 523791000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 523791000007 Walker B motif; other site 523791000008 arginine finger; other site 523791000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 523791000010 DnaA box-binding interface [nucleotide binding]; other site 523791000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 523791000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 523791000013 putative DNA binding surface [nucleotide binding]; other site 523791000014 dimer interface [polypeptide binding]; other site 523791000015 beta-clamp/clamp loader binding surface; other site 523791000016 beta-clamp/translesion DNA polymerase binding surface; other site 523791000017 recombination protein F; Reviewed; Region: recF; PRK00064 523791000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791000019 Walker A/P-loop; other site 523791000020 ATP binding site [chemical binding]; other site 523791000021 Q-loop/lid; other site 523791000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791000023 ABC transporter signature motif; other site 523791000024 Walker B; other site 523791000025 D-loop; other site 523791000026 H-loop/switch region; other site 523791000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 523791000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791000029 ATP binding site [chemical binding]; other site 523791000030 Mg2+ binding site [ion binding]; other site 523791000031 G-X-G motif; other site 523791000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 523791000033 anchoring element; other site 523791000034 dimer interface [polypeptide binding]; other site 523791000035 ATP binding site [chemical binding]; other site 523791000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 523791000037 active site 523791000038 putative metal-binding site [ion binding]; other site 523791000039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 523791000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 523791000041 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 523791000042 Dodecin; Region: Dodecin; pfam07311 523791000043 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 523791000044 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523791000045 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 523791000046 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 523791000047 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 523791000048 Walker A motif; other site 523791000049 ATP binding site [chemical binding]; other site 523791000050 Walker B motif; other site 523791000051 Membrane fusogenic activity; Region: BMFP; pfam04380 523791000052 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 523791000053 Uncharacterized conserved protein [Function unknown]; Region: COG1739 523791000054 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 523791000055 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 523791000056 proline dipeptidase; Provisional; Region: PRK13607 523791000057 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 523791000058 active site 523791000059 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 523791000060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523791000061 substrate binding site [chemical binding]; other site 523791000062 oxyanion hole (OAH) forming residues; other site 523791000063 trimer interface [polypeptide binding]; other site 523791000064 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 523791000065 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 523791000066 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 523791000067 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 523791000068 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523791000069 dimer interface [polypeptide binding]; other site 523791000070 active site 523791000071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523791000072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791000073 active site 523791000074 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 523791000075 Part of AAA domain; Region: AAA_19; pfam13245 523791000076 Family description; Region: UvrD_C_2; pfam13538 523791000077 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 523791000078 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 523791000079 Protein export membrane protein; Region: SecD_SecF; cl14618 523791000080 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 523791000081 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 523791000082 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523791000083 active site residue [active] 523791000084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523791000085 dimerization interface [polypeptide binding]; other site 523791000086 putative DNA binding site [nucleotide binding]; other site 523791000087 putative Zn2+ binding site [ion binding]; other site 523791000088 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 523791000089 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523791000090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791000091 catalytic residue [active] 523791000092 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523791000093 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791000094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791000095 DNA binding residues [nucleotide binding] 523791000096 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 523791000097 active site 523791000098 catalytic triad [active] 523791000099 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 523791000100 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 523791000101 Helix-turn-helix domain; Region: HTH_28; pfam13518 523791000102 Winged helix-turn helix; Region: HTH_29; pfam13551 523791000103 Integrase core domain; Region: rve; pfam00665 523791000104 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 523791000105 Bacterial TniB protein; Region: TniB; pfam05621 523791000106 AAA domain; Region: AAA_22; pfam13401 523791000107 TniQ; Region: TniQ; pfam06527 523791000108 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 523791000109 Predicted transcriptional regulator [Transcription]; Region: COG2378 523791000110 WYL domain; Region: WYL; pfam13280 523791000111 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 523791000112 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 523791000113 MT-A70; Region: MT-A70; cl01947 523791000114 Domain of unknown function (DUF955); Region: DUF955; pfam06114 523791000115 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 523791000116 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 523791000117 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 523791000118 ThiF family; Region: ThiF; pfam00899 523791000119 ATP binding site [chemical binding]; other site 523791000120 substrate interface [chemical binding]; other site 523791000121 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 523791000122 active site 523791000123 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 523791000124 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 523791000125 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 523791000126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 523791000127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791000128 AAA domain; Region: AAA_23; pfam13476 523791000129 Walker A/P-loop; other site 523791000130 ATP binding site [chemical binding]; other site 523791000131 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 523791000132 putative active site [active] 523791000133 putative metal-binding site [ion binding]; other site 523791000134 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 523791000135 Part of AAA domain; Region: AAA_19; pfam13245 523791000136 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 523791000137 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 523791000138 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 523791000139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791000140 Walker A motif; other site 523791000141 ATP binding site [chemical binding]; other site 523791000142 Walker B motif; other site 523791000143 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 523791000144 Uncharacterized conserved protein (DUF2352); Region: DUF2352; pfam09817 523791000145 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 523791000146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523791000147 dimerization interface [polypeptide binding]; other site 523791000148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791000149 dimer interface [polypeptide binding]; other site 523791000150 phosphorylation site [posttranslational modification] 523791000151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791000152 ATP binding site [chemical binding]; other site 523791000153 Mg2+ binding site [ion binding]; other site 523791000154 G-X-G motif; other site 523791000155 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 523791000156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000157 active site 523791000158 phosphorylation site [posttranslational modification] 523791000159 intermolecular recognition site; other site 523791000160 dimerization interface [polypeptide binding]; other site 523791000161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791000162 DNA binding site [nucleotide binding] 523791000163 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 523791000164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000166 metal binding site [ion binding]; metal-binding site 523791000167 active site 523791000168 I-site; other site 523791000169 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000171 metal binding site [ion binding]; metal-binding site 523791000172 active site 523791000173 I-site; other site 523791000174 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 523791000175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523791000176 DNA-binding site [nucleotide binding]; DNA binding site 523791000177 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 523791000178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523791000179 Walker A/P-loop; other site 523791000180 ATP binding site [chemical binding]; other site 523791000181 Q-loop/lid; other site 523791000182 ABC transporter signature motif; other site 523791000183 Walker B; other site 523791000184 D-loop; other site 523791000185 H-loop/switch region; other site 523791000186 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 523791000187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791000188 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523791000189 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523791000190 ATP binding site [chemical binding]; other site 523791000191 Mg++ binding site [ion binding]; other site 523791000192 motif III; other site 523791000193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791000194 nucleotide binding region [chemical binding]; other site 523791000195 ATP-binding site [chemical binding]; other site 523791000196 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 523791000197 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 523791000198 DNA binding residues [nucleotide binding] 523791000199 putative dimer interface [polypeptide binding]; other site 523791000200 putative metal binding residues [ion binding]; other site 523791000201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523791000202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791000203 Coenzyme A binding pocket [chemical binding]; other site 523791000204 Predicted transcriptional regulator [Transcription]; Region: COG3655 523791000205 salt bridge; other site 523791000206 non-specific DNA binding site [nucleotide binding]; other site 523791000207 sequence-specific DNA binding site [nucleotide binding]; other site 523791000208 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791000209 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791000210 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791000211 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791000212 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791000213 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791000214 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791000215 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791000216 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 523791000217 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 523791000218 dimer interface [polypeptide binding]; other site 523791000219 active site 523791000220 heme binding site [chemical binding]; other site 523791000221 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 523791000222 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 523791000223 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 523791000224 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 523791000225 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 523791000226 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 523791000227 dinuclear metal binding motif [ion binding]; other site 523791000228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000229 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000230 metal binding site [ion binding]; metal-binding site 523791000231 active site 523791000232 I-site; other site 523791000233 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 523791000234 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 523791000235 Predicted flavoprotein [General function prediction only]; Region: COG0431 523791000236 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 523791000237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000239 metal binding site [ion binding]; metal-binding site 523791000240 active site 523791000241 I-site; other site 523791000242 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 523791000243 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 523791000244 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523791000245 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 523791000246 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523791000247 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 523791000248 PAS domain; Region: PAS_9; pfam13426 523791000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791000250 putative active site [active] 523791000251 heme pocket [chemical binding]; other site 523791000252 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 523791000253 GAF domain; Region: GAF_3; pfam13492 523791000254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000256 metal binding site [ion binding]; metal-binding site 523791000257 active site 523791000258 I-site; other site 523791000259 TspO/MBR family; Region: TspO_MBR; pfam03073 523791000260 Predicted membrane protein [Function unknown]; Region: COG1971 523791000261 Domain of unknown function DUF; Region: DUF204; pfam02659 523791000262 Domain of unknown function DUF; Region: DUF204; pfam02659 523791000263 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 523791000264 Domain of unknown function DUF21; Region: DUF21; pfam01595 523791000265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523791000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791000267 TPR motif; other site 523791000268 binding surface 523791000269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791000270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000271 metal binding site [ion binding]; metal-binding site 523791000272 active site 523791000273 I-site; other site 523791000274 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 523791000275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 523791000276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523791000277 dimer interface [polypeptide binding]; other site 523791000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791000279 catalytic residue [active] 523791000280 Uncharacterized conserved protein [Function unknown]; Region: COG3603 523791000281 Family description; Region: ACT_7; pfam13840 523791000282 Tic20-like protein; Region: Tic20; pfam09685 523791000283 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 523791000284 ThiC-associated domain; Region: ThiC-associated; pfam13667 523791000285 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 523791000286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523791000287 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 523791000288 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 523791000289 thiS-thiF/thiG interaction site; other site 523791000290 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 523791000291 ThiS interaction site; other site 523791000292 putative active site [active] 523791000293 tetramer interface [polypeptide binding]; other site 523791000294 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 523791000295 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 523791000296 dimer interface [polypeptide binding]; other site 523791000297 substrate binding site [chemical binding]; other site 523791000298 ATP binding site [chemical binding]; other site 523791000299 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 523791000300 thiamine phosphate binding site [chemical binding]; other site 523791000301 active site 523791000302 pyrophosphate binding site [ion binding]; other site 523791000303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523791000304 active site residue [active] 523791000305 hypothetical protein; Provisional; Region: PRK10350 523791000306 Bacterial PH domain; Region: DUF304; cl01348 523791000307 Predicted membrane protein [Function unknown]; Region: COG3428 523791000308 Bacterial PH domain; Region: DUF304; pfam03703 523791000309 Bacterial PH domain; Region: DUF304; cl01348 523791000310 Bacterial PH domain; Region: DUF304; pfam03703 523791000311 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 523791000312 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 523791000313 substrate-cofactor binding pocket; other site 523791000314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791000315 catalytic residue [active] 523791000316 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 523791000317 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 523791000318 NAD(P) binding site [chemical binding]; other site 523791000319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791000320 Coenzyme A binding pocket [chemical binding]; other site 523791000321 Rhomboid family; Region: Rhomboid; cl11446 523791000322 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 523791000323 active site residue [active] 523791000324 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 523791000325 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 523791000326 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 523791000327 catalytic residue [active] 523791000328 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 523791000329 catalytic residues [active] 523791000330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791000331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523791000332 peroxiredoxin; Region: AhpC; TIGR03137 523791000333 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 523791000334 dimer interface [polypeptide binding]; other site 523791000335 decamer (pentamer of dimers) interface [polypeptide binding]; other site 523791000336 catalytic triad [active] 523791000337 peroxidatic and resolving cysteines [active] 523791000338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791000339 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 523791000340 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 523791000341 dimerization interface [polypeptide binding]; other site 523791000342 Chorismate lyase; Region: Chor_lyase; cl01230 523791000343 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 523791000344 UbiA prenyltransferase family; Region: UbiA; pfam01040 523791000345 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 523791000346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 523791000347 putative acyl-acceptor binding pocket; other site 523791000348 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 523791000349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 523791000350 dimer interface [polypeptide binding]; other site 523791000351 active site 523791000352 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523791000353 catalytic residues [active] 523791000354 substrate binding site [chemical binding]; other site 523791000355 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 523791000356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523791000357 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 523791000358 acyl-activating enzyme (AAE) consensus motif; other site 523791000359 acyl-activating enzyme (AAE) consensus motif; other site 523791000360 putative AMP binding site [chemical binding]; other site 523791000361 putative active site [active] 523791000362 putative CoA binding site [chemical binding]; other site 523791000363 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 523791000364 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 523791000365 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 523791000366 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 523791000367 substrate binding site [chemical binding]; other site 523791000368 hexamer interface [polypeptide binding]; other site 523791000369 metal binding site [ion binding]; metal-binding site 523791000370 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 523791000371 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 523791000372 glutamine binding [chemical binding]; other site 523791000373 catalytic triad [active] 523791000374 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 523791000375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 523791000376 ligand binding site [chemical binding]; other site 523791000377 flexible hinge region; other site 523791000378 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 523791000379 putative switch regulator; other site 523791000380 non-specific DNA interactions [nucleotide binding]; other site 523791000381 DNA binding site [nucleotide binding] 523791000382 sequence specific DNA binding site [nucleotide binding]; other site 523791000383 putative cAMP binding site [chemical binding]; other site 523791000384 OsmC-like protein; Region: OsmC; cl00767 523791000385 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791000386 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 523791000387 active site 523791000388 metal binding site [ion binding]; metal-binding site 523791000389 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 523791000390 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 523791000391 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 523791000392 dimer interface [polypeptide binding]; other site 523791000393 active site 523791000394 heme binding site [chemical binding]; other site 523791000395 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 523791000396 Cytochrome c; Region: Cytochrom_C; cl11414 523791000397 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 523791000398 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 523791000399 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 523791000400 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 523791000401 shikimate binding site; other site 523791000402 NAD(P) binding site [chemical binding]; other site 523791000403 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 523791000404 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 523791000405 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 523791000406 HemY protein N-terminus; Region: HemY_N; pfam07219 523791000407 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 523791000408 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 523791000409 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 523791000410 active site 523791000411 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 523791000412 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 523791000413 domain interfaces; other site 523791000414 active site 523791000415 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 523791000416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000417 active site 523791000418 phosphorylation site [posttranslational modification] 523791000419 intermolecular recognition site; other site 523791000420 dimerization interface [polypeptide binding]; other site 523791000421 LytTr DNA-binding domain; Region: LytTR; smart00850 523791000422 Histidine kinase; Region: His_kinase; pfam06580 523791000423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791000424 metal binding site [ion binding]; metal-binding site 523791000425 active site 523791000426 I-site; other site 523791000427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791000428 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 523791000429 putative hydrolase; Provisional; Region: PRK11460 523791000430 frataxin-like protein; Provisional; Region: cyaY; PRK00446 523791000431 putative iron binding site [ion binding]; other site 523791000432 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 523791000433 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 523791000434 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 523791000435 Protein of unknown function, DUF484; Region: DUF484; cl17449 523791000436 GAF domain; Region: GAF_2; pfam13185 523791000437 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 523791000438 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523791000439 active site 523791000440 DNA binding site [nucleotide binding] 523791000441 Int/Topo IB signature motif; other site 523791000442 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 523791000443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791000444 motif II; other site 523791000445 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 523791000446 glycerate dehydrogenase; Provisional; Region: PRK06487 523791000447 putative ligand binding site [chemical binding]; other site 523791000448 putative NAD binding site [chemical binding]; other site 523791000449 catalytic site [active] 523791000450 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 523791000451 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 523791000452 Part of AAA domain; Region: AAA_19; pfam13245 523791000453 Family description; Region: UvrD_C_2; pfam13538 523791000454 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 523791000455 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 523791000456 active site 523791000457 catalytic residues [active] 523791000458 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 523791000459 PA/subtilisin-like domain interface [polypeptide binding]; other site 523791000460 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791000461 catalytic residues [active] 523791000462 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791000463 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791000464 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 523791000465 active site 523791000466 catalytic residues [active] 523791000467 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 523791000468 PA/protease or protease-like domain interface [polypeptide binding]; other site 523791000469 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791000470 catalytic residues [active] 523791000471 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 523791000472 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 523791000473 active site 523791000474 catalytic residues [active] 523791000475 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 523791000476 PA/protease or protease-like domain interface [polypeptide binding]; other site 523791000477 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791000478 catalytic residues [active] 523791000479 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791000480 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 523791000481 active site 523791000482 catalytic triad [active] 523791000483 calcium binding site 1 [ion binding]; other site 523791000484 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791000485 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 523791000486 active site 523791000487 catalytic triad [active] 523791000488 calcium binding site 1 [ion binding]; other site 523791000489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 523791000490 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 523791000491 glutamate racemase; Provisional; Region: PRK00865 523791000492 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 523791000493 DctM-like transporters; Region: DctM; pfam06808 523791000494 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 523791000495 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791000496 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791000497 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 523791000498 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 523791000499 TfoX N-terminal domain; Region: TfoX_N; pfam04993 523791000500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 523791000501 Predicted ATPase [General function prediction only]; Region: COG5293 523791000502 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 523791000503 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 523791000504 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523791000505 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523791000506 active site 523791000507 ATP binding site [chemical binding]; other site 523791000508 substrate binding site [chemical binding]; other site 523791000509 activation loop (A-loop); other site 523791000510 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 523791000511 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 523791000512 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 523791000513 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 523791000514 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 523791000515 active site residues [active] 523791000516 dimer interface [polypeptide binding]; other site 523791000517 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 523791000518 oxidative damage protection protein; Provisional; Region: PRK05408 523791000519 adenine DNA glycosylase; Provisional; Region: PRK10880 523791000520 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523791000521 minor groove reading motif; other site 523791000522 helix-hairpin-helix signature motif; other site 523791000523 substrate binding pocket [chemical binding]; other site 523791000524 active site 523791000525 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 523791000526 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 523791000527 DNA binding and oxoG recognition site [nucleotide binding] 523791000528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523791000529 transmembrane helices; other site 523791000530 TrkA-C domain; Region: TrkA_C; pfam02080 523791000531 TrkA-C domain; Region: TrkA_C; pfam02080 523791000532 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523791000533 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523791000534 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 523791000535 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 523791000536 Predicted membrane protein [Function unknown]; Region: COG3650 523791000537 META domain; Region: META; pfam03724 523791000538 HemN family oxidoreductase; Provisional; Region: PRK05660 523791000539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791000540 FeS/SAM binding site; other site 523791000541 HemN C-terminal domain; Region: HemN_C; pfam06969 523791000542 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 523791000543 active site 523791000544 dimerization interface [polypeptide binding]; other site 523791000545 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 523791000546 YGGT family; Region: YGGT; pfam02325 523791000547 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 523791000548 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 523791000549 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 523791000550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523791000551 catalytic residue [active] 523791000552 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 523791000553 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 523791000554 Walker A motif; other site 523791000555 ATP binding site [chemical binding]; other site 523791000556 Walker B motif; other site 523791000557 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 523791000558 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523791000559 Walker A motif; other site 523791000560 ATP binding site [chemical binding]; other site 523791000561 Walker B motif; other site 523791000562 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 523791000563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791000564 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 523791000565 hypothetical protein; Validated; Region: PRK00228 523791000566 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 523791000567 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791000568 glutathione synthetase; Provisional; Region: PRK05246 523791000569 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 523791000570 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 523791000571 Response regulator receiver domain; Region: Response_reg; pfam00072 523791000572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000573 active site 523791000574 phosphorylation site [posttranslational modification] 523791000575 intermolecular recognition site; other site 523791000576 dimerization interface [polypeptide binding]; other site 523791000577 Response regulator receiver domain; Region: Response_reg; pfam00072 523791000578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000579 active site 523791000580 phosphorylation site [posttranslational modification] 523791000581 intermolecular recognition site; other site 523791000582 dimerization interface [polypeptide binding]; other site 523791000583 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 523791000584 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 523791000585 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 523791000586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 523791000587 dimer interface [polypeptide binding]; other site 523791000588 putative CheW interface [polypeptide binding]; other site 523791000589 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 523791000590 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 523791000591 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 523791000592 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 523791000593 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 523791000594 putative binding surface; other site 523791000595 active site 523791000596 Hpt domain; Region: Hpt; pfam01627 523791000597 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 523791000598 putative binding surface; other site 523791000599 active site 523791000600 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 523791000601 putative binding surface; other site 523791000602 active site 523791000603 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 523791000604 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 523791000605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791000606 ATP binding site [chemical binding]; other site 523791000607 Mg2+ binding site [ion binding]; other site 523791000608 G-X-G motif; other site 523791000609 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 523791000610 Response regulator receiver domain; Region: Response_reg; pfam00072 523791000611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000612 active site 523791000613 phosphorylation site [posttranslational modification] 523791000614 intermolecular recognition site; other site 523791000615 dimerization interface [polypeptide binding]; other site 523791000616 CheB methylesterase; Region: CheB_methylest; pfam01339 523791000617 CheW-like domain; Region: CheW; pfam01584 523791000618 RNA methyltransferase, RsmE family; Region: TIGR00046 523791000619 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 523791000620 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 523791000621 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523791000622 inhibitor-cofactor binding pocket; inhibition site 523791000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791000624 catalytic residue [active] 523791000625 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 523791000626 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 523791000627 homotetramer interface [polypeptide binding]; other site 523791000628 ligand binding site [chemical binding]; other site 523791000629 catalytic site [active] 523791000630 NAD binding site [chemical binding]; other site 523791000631 S-adenosylmethionine synthetase; Validated; Region: PRK05250 523791000632 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 523791000633 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 523791000634 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 523791000635 Ion transport protein; Region: Ion_trans; pfam00520 523791000636 Ion channel; Region: Ion_trans_2; pfam07885 523791000637 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 523791000638 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 523791000639 diiron binding motif [ion binding]; other site 523791000640 Ycf46; Provisional; Region: ycf46; CHL00195 523791000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791000642 Walker A motif; other site 523791000643 ATP binding site [chemical binding]; other site 523791000644 Walker B motif; other site 523791000645 arginine finger; other site 523791000646 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 523791000647 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 523791000648 putative C-terminal domain interface [polypeptide binding]; other site 523791000649 putative GSH binding site (G-site) [chemical binding]; other site 523791000650 putative dimer interface [polypeptide binding]; other site 523791000651 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 523791000652 N-terminal domain interface [polypeptide binding]; other site 523791000653 dimer interface [polypeptide binding]; other site 523791000654 substrate binding pocket (H-site) [chemical binding]; other site 523791000655 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 523791000656 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 523791000657 Dicarboxylate transport; Region: DctA-YdbH; cl14674 523791000658 Dicarboxylate transport; Region: DctA-YdbH; cl14674 523791000659 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 523791000660 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 523791000661 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 523791000662 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 523791000663 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 523791000664 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 523791000665 purine monophosphate binding site [chemical binding]; other site 523791000666 dimer interface [polypeptide binding]; other site 523791000667 putative catalytic residues [active] 523791000668 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 523791000669 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 523791000670 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 523791000671 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 523791000672 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 523791000673 FMN binding site [chemical binding]; other site 523791000674 active site 523791000675 catalytic residues [active] 523791000676 substrate binding site [chemical binding]; other site 523791000677 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 523791000678 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 523791000679 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 523791000680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791000681 S-adenosylmethionine binding site [chemical binding]; other site 523791000682 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 523791000683 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 523791000684 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523791000685 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523791000686 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 523791000687 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 523791000688 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523791000689 carboxyltransferase (CT) interaction site; other site 523791000690 biotinylation site [posttranslational modification]; other site 523791000691 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 523791000692 Dehydroquinase class II; Region: DHquinase_II; pfam01220 523791000693 active site 523791000694 trimer interface [polypeptide binding]; other site 523791000695 dimer interface [polypeptide binding]; other site 523791000696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523791000697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000698 active site 523791000699 phosphorylation site [posttranslational modification] 523791000700 dimerization interface [polypeptide binding]; other site 523791000701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791000702 DNA binding site [nucleotide binding] 523791000703 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 523791000704 EamA-like transporter family; Region: EamA; pfam00892 523791000705 EamA-like transporter family; Region: EamA; pfam00892 523791000706 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 523791000707 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 523791000708 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 523791000709 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 523791000710 DsbD alpha interface [polypeptide binding]; other site 523791000711 catalytic residues [active] 523791000712 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 523791000713 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 523791000714 ApbE family; Region: ApbE; pfam02424 523791000715 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 523791000716 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 523791000717 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523791000718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791000719 catalytic residues [active] 523791000720 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 523791000721 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 523791000722 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 523791000723 oligomerisation interface [polypeptide binding]; other site 523791000724 mobile loop; other site 523791000725 roof hairpin; other site 523791000726 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 523791000727 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 523791000728 ring oligomerisation interface [polypeptide binding]; other site 523791000729 ATP/Mg binding site [chemical binding]; other site 523791000730 stacking interactions; other site 523791000731 hinge regions; other site 523791000732 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 523791000733 active site clefts [active] 523791000734 zinc binding site [ion binding]; other site 523791000735 dimer interface [polypeptide binding]; other site 523791000736 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 523791000737 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523791000738 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791000739 ligand binding site [chemical binding]; other site 523791000740 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 523791000741 von Willebrand factor; Region: vWF_A; pfam12450 523791000742 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 523791000743 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 523791000744 metal ion-dependent adhesion site (MIDAS); other site 523791000745 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 523791000746 RNA polymerase sigma factor; Provisional; Region: PRK12513 523791000747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791000748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791000749 DNA binding residues [nucleotide binding] 523791000750 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 523791000751 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 523791000752 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 523791000753 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 523791000754 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 523791000755 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 523791000756 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 523791000757 Subunit I/III interface [polypeptide binding]; other site 523791000758 D-pathway; other site 523791000759 Subunit I/VIIc interface [polypeptide binding]; other site 523791000760 Subunit I/IV interface [polypeptide binding]; other site 523791000761 Subunit I/II interface [polypeptide binding]; other site 523791000762 Low-spin heme (heme a) binding site [chemical binding]; other site 523791000763 Subunit I/VIIa interface [polypeptide binding]; other site 523791000764 Subunit I/VIa interface [polypeptide binding]; other site 523791000765 Dimer interface; other site 523791000766 Putative water exit pathway; other site 523791000767 Binuclear center (heme a3/CuB) [ion binding]; other site 523791000768 K-pathway; other site 523791000769 Putative proton exit pathway; other site 523791000770 Subunit I/VIb interface; other site 523791000771 Subunit I/VIc interface [polypeptide binding]; other site 523791000772 Electron transfer pathway; other site 523791000773 Subunit I/VIIIb interface [polypeptide binding]; other site 523791000774 Subunit I/VIIb interface [polypeptide binding]; other site 523791000775 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 523791000776 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 523791000777 Subunit III/VIIa interface [polypeptide binding]; other site 523791000778 Phospholipid binding site [chemical binding]; other site 523791000779 Subunit I/III interface [polypeptide binding]; other site 523791000780 Subunit III/VIb interface [polypeptide binding]; other site 523791000781 Subunit III/VIa interface; other site 523791000782 Subunit III/Vb interface [polypeptide binding]; other site 523791000783 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 523791000784 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 523791000785 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 523791000786 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 523791000787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791000788 Zn2+ binding site [ion binding]; other site 523791000789 Mg2+ binding site [ion binding]; other site 523791000790 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 523791000791 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 523791000792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791000793 Zn2+ binding site [ion binding]; other site 523791000794 Mg2+ binding site [ion binding]; other site 523791000795 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 523791000796 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 523791000797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791000798 Zn2+ binding site [ion binding]; other site 523791000799 Mg2+ binding site [ion binding]; other site 523791000800 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 523791000801 NADH dehydrogenase subunit B; Validated; Region: PRK06411 523791000802 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 523791000803 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 523791000804 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 523791000805 NADH dehydrogenase subunit D; Validated; Region: PRK06075 523791000806 NADH dehydrogenase subunit E; Validated; Region: PRK07539 523791000807 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 523791000808 putative dimer interface [polypeptide binding]; other site 523791000809 [2Fe-2S] cluster binding site [ion binding]; other site 523791000810 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 523791000811 SLBB domain; Region: SLBB; pfam10531 523791000812 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 523791000813 NADH dehydrogenase subunit G; Validated; Region: PRK09129 523791000814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 523791000815 catalytic loop [active] 523791000816 iron binding site [ion binding]; other site 523791000817 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 523791000818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 523791000819 molybdopterin cofactor binding site; other site 523791000820 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 523791000821 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 523791000822 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 523791000823 4Fe-4S binding domain; Region: Fer4; pfam00037 523791000824 4Fe-4S binding domain; Region: Fer4; pfam00037 523791000825 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 523791000826 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 523791000827 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 523791000828 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 523791000829 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 523791000830 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791000831 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 523791000832 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791000833 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 523791000834 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791000835 ribosome maturation protein RimP; Reviewed; Region: PRK00092 523791000836 Sm and related proteins; Region: Sm_like; cl00259 523791000837 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 523791000838 putative oligomer interface [polypeptide binding]; other site 523791000839 putative RNA binding site [nucleotide binding]; other site 523791000840 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 523791000841 NusA N-terminal domain; Region: NusA_N; pfam08529 523791000842 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 523791000843 RNA binding site [nucleotide binding]; other site 523791000844 homodimer interface [polypeptide binding]; other site 523791000845 NusA-like KH domain; Region: KH_5; pfam13184 523791000846 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 523791000847 G-X-X-G motif; other site 523791000848 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 523791000849 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 523791000850 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 523791000851 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 523791000852 translation initiation factor IF-2; Region: IF-2; TIGR00487 523791000853 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 523791000854 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 523791000855 G1 box; other site 523791000856 putative GEF interaction site [polypeptide binding]; other site 523791000857 GTP/Mg2+ binding site [chemical binding]; other site 523791000858 Switch I region; other site 523791000859 G2 box; other site 523791000860 G3 box; other site 523791000861 Switch II region; other site 523791000862 G4 box; other site 523791000863 G5 box; other site 523791000864 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 523791000865 Translation-initiation factor 2; Region: IF-2; pfam11987 523791000866 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 523791000867 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 523791000868 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 523791000869 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 523791000870 RNA binding site [nucleotide binding]; other site 523791000871 active site 523791000872 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 523791000873 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523791000874 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791000875 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 523791000876 16S/18S rRNA binding site [nucleotide binding]; other site 523791000877 S13e-L30e interaction site [polypeptide binding]; other site 523791000878 25S rRNA binding site [nucleotide binding]; other site 523791000879 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 523791000880 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 523791000881 RNase E interface [polypeptide binding]; other site 523791000882 trimer interface [polypeptide binding]; other site 523791000883 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 523791000884 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 523791000885 RNase E interface [polypeptide binding]; other site 523791000886 trimer interface [polypeptide binding]; other site 523791000887 active site 523791000888 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 523791000889 putative nucleic acid binding region [nucleotide binding]; other site 523791000890 G-X-X-G motif; other site 523791000891 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 523791000892 RNA binding site [nucleotide binding]; other site 523791000893 domain interface; other site 523791000894 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 523791000895 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 523791000896 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 523791000897 active site 523791000898 Zn binding site [ion binding]; other site 523791000899 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791000900 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791000901 YceI-like domain; Region: YceI; pfam04264 523791000902 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 523791000903 Na binding site [ion binding]; other site 523791000904 putative glycosylation site [posttranslational modification]; other site 523791000905 putative glycosylation site [posttranslational modification]; other site 523791000906 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 523791000907 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523791000908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791000909 FeS/SAM binding site; other site 523791000910 TRAM domain; Region: TRAM; pfam01938 523791000911 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 523791000912 PhoH-like protein; Region: PhoH; pfam02562 523791000913 metal-binding heat shock protein; Provisional; Region: PRK00016 523791000914 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 523791000915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523791000916 Transporter associated domain; Region: CorC_HlyC; smart01091 523791000917 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 523791000918 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 523791000919 putative active site [active] 523791000920 catalytic triad [active] 523791000921 putative dimer interface [polypeptide binding]; other site 523791000922 Peptidase M30; Region: Peptidase_M30; pfam10460 523791000923 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 523791000924 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 523791000925 HIGH motif; other site 523791000926 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523791000927 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523791000928 active site 523791000929 KMSKS motif; other site 523791000930 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 523791000931 tRNA binding surface [nucleotide binding]; other site 523791000932 Lipopolysaccharide-assembly; Region: LptE; cl01125 523791000933 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 523791000934 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 523791000935 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 523791000936 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 523791000937 active site 523791000938 (T/H)XGH motif; other site 523791000939 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 523791000940 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 523791000941 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 523791000942 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 523791000943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523791000944 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 523791000945 Transglycosylase SLT domain; Region: SLT_2; pfam13406 523791000946 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791000947 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791000948 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 523791000949 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 523791000950 Sporulation related domain; Region: SPOR; pfam05036 523791000951 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 523791000952 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 523791000953 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 523791000954 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 523791000955 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 523791000956 homodimer interface [polypeptide binding]; other site 523791000957 substrate-cofactor binding pocket; other site 523791000958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791000959 catalytic residue [active] 523791000960 Protein of unknown function (DUF493); Region: DUF493; pfam04359 523791000961 lipoate-protein ligase B; Provisional; Region: PRK14342 523791000962 lipoyl synthase; Provisional; Region: PRK05481 523791000963 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791000964 FeS/SAM binding site; other site 523791000965 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 523791000966 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791000967 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 523791000968 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 523791000969 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 523791000970 N-terminal domain interface [polypeptide binding]; other site 523791000971 dimer interface [polypeptide binding]; other site 523791000972 substrate binding pocket (H-site) [chemical binding]; other site 523791000973 Peptidase family M48; Region: Peptidase_M48; pfam01435 523791000974 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523791000975 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 523791000976 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 523791000977 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 523791000978 two-component sensor protein; Provisional; Region: cpxA; PRK09470 523791000979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523791000980 dimerization interface [polypeptide binding]; other site 523791000981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791000982 dimer interface [polypeptide binding]; other site 523791000983 phosphorylation site [posttranslational modification] 523791000984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791000985 ATP binding site [chemical binding]; other site 523791000986 Mg2+ binding site [ion binding]; other site 523791000987 G-X-G motif; other site 523791000988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523791000989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791000990 active site 523791000991 phosphorylation site [posttranslational modification] 523791000992 intermolecular recognition site; other site 523791000993 dimerization interface [polypeptide binding]; other site 523791000994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791000995 DNA binding site [nucleotide binding] 523791000996 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 523791000997 acetyl-CoA synthetase; Provisional; Region: PRK00174 523791000998 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 523791000999 active site 523791001000 CoA binding site [chemical binding]; other site 523791001001 acyl-activating enzyme (AAE) consensus motif; other site 523791001002 AMP binding site [chemical binding]; other site 523791001003 acetate binding site [chemical binding]; other site 523791001004 pantoate--beta-alanine ligase; Region: panC; TIGR00018 523791001005 Pantoate-beta-alanine ligase; Region: PanC; cd00560 523791001006 active site 523791001007 ATP-binding site [chemical binding]; other site 523791001008 pantoate-binding site; other site 523791001009 HXXH motif; other site 523791001010 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 523791001011 oligomerization interface [polypeptide binding]; other site 523791001012 active site 523791001013 metal binding site [ion binding]; metal-binding site 523791001014 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 523791001015 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 523791001016 Substrate-binding site [chemical binding]; other site 523791001017 Substrate specificity [chemical binding]; other site 523791001018 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 523791001019 catalytic center binding site [active] 523791001020 ATP binding site [chemical binding]; other site 523791001021 poly(A) polymerase; Region: pcnB; TIGR01942 523791001022 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 523791001023 active site 523791001024 NTP binding site [chemical binding]; other site 523791001025 metal binding triad [ion binding]; metal-binding site 523791001026 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 523791001027 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 523791001028 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 523791001029 active site 523791001030 HIGH motif; other site 523791001031 nucleotide binding site [chemical binding]; other site 523791001032 active site 523791001033 KMSKS motif; other site 523791001034 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 523791001035 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 523791001036 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 523791001037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791001038 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 523791001039 putative active site [active] 523791001040 heme pocket [chemical binding]; other site 523791001041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791001042 putative active site [active] 523791001043 heme pocket [chemical binding]; other site 523791001044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791001045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791001046 metal binding site [ion binding]; metal-binding site 523791001047 active site 523791001048 I-site; other site 523791001049 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791001050 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 523791001051 iron-sulfur cluster [ion binding]; other site 523791001052 [2Fe-2S] cluster binding site [ion binding]; other site 523791001053 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 523791001054 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523791001055 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 523791001056 dimerization interface [polypeptide binding]; other site 523791001057 active site 523791001058 aminopeptidase B; Provisional; Region: PRK05015 523791001059 Peptidase; Region: DUF3663; pfam12404 523791001060 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 523791001061 interface (dimer of trimers) [polypeptide binding]; other site 523791001062 Substrate-binding/catalytic site; other site 523791001063 Zn-binding sites [ion binding]; other site 523791001064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791001065 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 523791001066 active site 523791001067 homodimer interface [polypeptide binding]; other site 523791001068 SAM binding site [chemical binding]; other site 523791001069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791001070 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 523791001071 active site 523791001072 SAM binding site [chemical binding]; other site 523791001073 homodimer interface [polypeptide binding]; other site 523791001074 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791001075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791001076 metal binding site [ion binding]; metal-binding site 523791001077 active site 523791001078 I-site; other site 523791001079 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 523791001080 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 523791001081 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 523791001082 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 523791001083 Transglycosylase; Region: Transgly; pfam00912 523791001084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 523791001085 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 523791001086 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 523791001087 Peptidase family M28; Region: Peptidase_M28; pfam04389 523791001088 metal binding site [ion binding]; metal-binding site 523791001089 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 523791001090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523791001091 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 523791001092 kynureninase; Region: kynureninase; TIGR01814 523791001093 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523791001094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791001095 catalytic residue [active] 523791001096 Putative cyclase; Region: Cyclase; pfam04199 523791001097 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 523791001098 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 523791001099 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 523791001100 homotrimer interaction site [polypeptide binding]; other site 523791001101 putative active site [active] 523791001102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 523791001103 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 523791001104 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 523791001105 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 523791001106 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 523791001107 active site 523791001108 active site 523791001109 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 523791001110 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 523791001111 NAD binding site [chemical binding]; other site 523791001112 catalytic residues [active] 523791001113 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 523791001114 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 523791001115 putative NAD(P) binding site [chemical binding]; other site 523791001116 putative active site [active] 523791001117 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 523791001118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791001119 sequence-specific DNA binding site [nucleotide binding]; other site 523791001120 salt bridge; other site 523791001121 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 523791001122 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 523791001123 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523791001124 inhibitor-cofactor binding pocket; inhibition site 523791001125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791001126 catalytic residue [active] 523791001127 aspartate carbamoyltransferase; Provisional; Region: PRK08192 523791001128 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523791001129 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523791001130 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 523791001131 Rubredoxin; Region: Rubredoxin; pfam00301 523791001132 iron binding site [ion binding]; other site 523791001133 Protein of unknown function (DUF796); Region: DUF796; pfam05638 523791001134 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 523791001135 putative S-transferase; Provisional; Region: PRK11752 523791001136 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 523791001137 C-terminal domain interface [polypeptide binding]; other site 523791001138 GSH binding site (G-site) [chemical binding]; other site 523791001139 dimer interface [polypeptide binding]; other site 523791001140 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 523791001141 dimer interface [polypeptide binding]; other site 523791001142 N-terminal domain interface [polypeptide binding]; other site 523791001143 active site 523791001144 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523791001145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791001146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791001147 DNA binding residues [nucleotide binding] 523791001148 Putative zinc-finger; Region: zf-HC2; pfam13490 523791001149 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 523791001150 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 523791001151 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 523791001152 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 523791001153 SelR domain; Region: SelR; pfam01641 523791001154 Protein of unknown function (DUF817); Region: DUF817; pfam05675 523791001155 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 523791001156 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 523791001157 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 523791001158 Cl- selectivity filter; other site 523791001159 Cl- binding residues [ion binding]; other site 523791001160 pore gating glutamate residue; other site 523791001161 dimer interface [polypeptide binding]; other site 523791001162 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 523791001163 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 523791001164 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 523791001165 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 523791001166 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 523791001167 putative peptidase; Provisional; Region: PRK11649 523791001168 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791001169 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 523791001170 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 523791001171 active site 523791001172 HIGH motif; other site 523791001173 dimer interface [polypeptide binding]; other site 523791001174 KMSKS motif; other site 523791001175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791001176 RNA binding surface [nucleotide binding]; other site 523791001177 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791001178 active site 523791001179 catalytic residues [active] 523791001180 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 523791001181 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523791001182 ATP binding site [chemical binding]; other site 523791001183 Mg++ binding site [ion binding]; other site 523791001184 motif III; other site 523791001185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791001186 nucleotide binding region [chemical binding]; other site 523791001187 ATP-binding site [chemical binding]; other site 523791001188 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 523791001189 putative RNA binding site [nucleotide binding]; other site 523791001190 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791001191 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 523791001192 active site 523791001193 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 523791001194 FAD binding domain; Region: FAD_binding_4; pfam01565 523791001195 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 523791001196 Biotin operon repressor [Transcription]; Region: BirA; COG1654 523791001197 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 523791001198 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 523791001199 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 523791001200 Type III pantothenate kinase; Region: Pan_kinase; cl17198 523791001201 elongation factor Tu; Reviewed; Region: PRK00049 523791001202 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 523791001203 G1 box; other site 523791001204 GEF interaction site [polypeptide binding]; other site 523791001205 GTP/Mg2+ binding site [chemical binding]; other site 523791001206 Switch I region; other site 523791001207 G2 box; other site 523791001208 G3 box; other site 523791001209 Switch II region; other site 523791001210 G4 box; other site 523791001211 G5 box; other site 523791001212 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 523791001213 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 523791001214 Antibiotic Binding Site [chemical binding]; other site 523791001215 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 523791001216 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 523791001217 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 523791001218 putative homodimer interface [polypeptide binding]; other site 523791001219 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 523791001220 heterodimer interface [polypeptide binding]; other site 523791001221 homodimer interface [polypeptide binding]; other site 523791001222 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 523791001223 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 523791001224 23S rRNA interface [nucleotide binding]; other site 523791001225 L7/L12 interface [polypeptide binding]; other site 523791001226 putative thiostrepton binding site; other site 523791001227 L25 interface [polypeptide binding]; other site 523791001228 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 523791001229 mRNA/rRNA interface [nucleotide binding]; other site 523791001230 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 523791001231 23S rRNA interface [nucleotide binding]; other site 523791001232 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 523791001233 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 523791001234 L11 interface [polypeptide binding]; other site 523791001235 putative EF-Tu interaction site [polypeptide binding]; other site 523791001236 putative EF-G interaction site [polypeptide binding]; other site 523791001237 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 523791001238 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 523791001239 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 523791001240 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 523791001241 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 523791001242 RPB3 interaction site [polypeptide binding]; other site 523791001243 RPB1 interaction site [polypeptide binding]; other site 523791001244 RPB11 interaction site [polypeptide binding]; other site 523791001245 RPB10 interaction site [polypeptide binding]; other site 523791001246 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 523791001247 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 523791001248 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 523791001249 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 523791001250 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 523791001251 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 523791001252 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 523791001253 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 523791001254 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 523791001255 DNA binding site [nucleotide binding] 523791001256 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 523791001257 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 523791001258 S17 interaction site [polypeptide binding]; other site 523791001259 S8 interaction site; other site 523791001260 16S rRNA interaction site [nucleotide binding]; other site 523791001261 streptomycin interaction site [chemical binding]; other site 523791001262 23S rRNA interaction site [nucleotide binding]; other site 523791001263 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 523791001264 30S ribosomal protein S7; Validated; Region: PRK05302 523791001265 elongation factor G; Reviewed; Region: PRK00007 523791001266 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 523791001267 G1 box; other site 523791001268 putative GEF interaction site [polypeptide binding]; other site 523791001269 GTP/Mg2+ binding site [chemical binding]; other site 523791001270 Switch I region; other site 523791001271 G2 box; other site 523791001272 G3 box; other site 523791001273 Switch II region; other site 523791001274 G4 box; other site 523791001275 G5 box; other site 523791001276 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 523791001277 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 523791001278 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 523791001279 elongation factor Tu; Reviewed; Region: PRK00049 523791001280 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 523791001281 G1 box; other site 523791001282 GEF interaction site [polypeptide binding]; other site 523791001283 GTP/Mg2+ binding site [chemical binding]; other site 523791001284 Switch I region; other site 523791001285 G2 box; other site 523791001286 G3 box; other site 523791001287 Switch II region; other site 523791001288 G4 box; other site 523791001289 G5 box; other site 523791001290 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 523791001291 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 523791001292 Antibiotic Binding Site [chemical binding]; other site 523791001293 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 523791001294 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 523791001295 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 523791001296 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 523791001297 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 523791001298 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 523791001299 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 523791001300 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 523791001301 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 523791001302 protein-rRNA interface [nucleotide binding]; other site 523791001303 putative translocon binding site; other site 523791001304 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 523791001305 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 523791001306 G-X-X-G motif; other site 523791001307 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 523791001308 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 523791001309 23S rRNA interface [nucleotide binding]; other site 523791001310 5S rRNA interface [nucleotide binding]; other site 523791001311 putative antibiotic binding site [chemical binding]; other site 523791001312 L25 interface [polypeptide binding]; other site 523791001313 L27 interface [polypeptide binding]; other site 523791001314 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 523791001315 23S rRNA interface [nucleotide binding]; other site 523791001316 putative translocon interaction site; other site 523791001317 signal recognition particle (SRP54) interaction site; other site 523791001318 L23 interface [polypeptide binding]; other site 523791001319 trigger factor interaction site; other site 523791001320 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 523791001321 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 523791001322 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 523791001323 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 523791001324 RNA binding site [nucleotide binding]; other site 523791001325 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 523791001326 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 523791001327 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 523791001328 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 523791001329 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 523791001330 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 523791001331 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523791001332 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523791001333 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 523791001334 5S rRNA interface [nucleotide binding]; other site 523791001335 23S rRNA interface [nucleotide binding]; other site 523791001336 L5 interface [polypeptide binding]; other site 523791001337 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 523791001338 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 523791001339 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 523791001340 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 523791001341 23S rRNA binding site [nucleotide binding]; other site 523791001342 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 523791001343 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 523791001344 SecY translocase; Region: SecY; pfam00344 523791001345 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 523791001346 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 523791001347 30S ribosomal protein S13; Region: bact_S13; TIGR03631 523791001348 30S ribosomal protein S11; Validated; Region: PRK05309 523791001349 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 523791001350 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 523791001351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791001352 RNA binding surface [nucleotide binding]; other site 523791001353 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 523791001354 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 523791001355 alphaNTD homodimer interface [polypeptide binding]; other site 523791001356 alphaNTD - beta interaction site [polypeptide binding]; other site 523791001357 alphaNTD - beta' interaction site [polypeptide binding]; other site 523791001358 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 523791001359 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 523791001360 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 523791001361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791001362 S-adenosylmethionine binding site [chemical binding]; other site 523791001363 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523791001364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 523791001365 active site 523791001366 phosphorylation site [posttranslational modification] 523791001367 intermolecular recognition site; other site 523791001368 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791001369 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791001370 catalytic residue [active] 523791001371 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 523791001372 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 523791001373 dimer interface [polypeptide binding]; other site 523791001374 active site 523791001375 glycine-pyridoxal phosphate binding site [chemical binding]; other site 523791001376 folate binding site [chemical binding]; other site 523791001377 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 523791001378 ATP cone domain; Region: ATP-cone; pfam03477 523791001379 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 523791001380 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 523791001381 catalytic motif [active] 523791001382 Zn binding site [ion binding]; other site 523791001383 RibD C-terminal domain; Region: RibD_C; cl17279 523791001384 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 523791001385 Lumazine binding domain; Region: Lum_binding; pfam00677 523791001386 Lumazine binding domain; Region: Lum_binding; pfam00677 523791001387 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 523791001388 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 523791001389 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 523791001390 dimerization interface [polypeptide binding]; other site 523791001391 active site 523791001392 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 523791001393 homopentamer interface [polypeptide binding]; other site 523791001394 active site 523791001395 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 523791001396 putative RNA binding site [nucleotide binding]; other site 523791001397 thiamine monophosphate kinase; Provisional; Region: PRK05731 523791001398 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 523791001399 ATP binding site [chemical binding]; other site 523791001400 dimerization interface [polypeptide binding]; other site 523791001401 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 523791001402 tetramer interfaces [polypeptide binding]; other site 523791001403 binuclear metal-binding site [ion binding]; other site 523791001404 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 523791001405 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 523791001406 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 523791001407 TPP-binding site; other site 523791001408 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523791001409 PYR/PP interface [polypeptide binding]; other site 523791001410 dimer interface [polypeptide binding]; other site 523791001411 TPP binding site [chemical binding]; other site 523791001412 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523791001413 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 523791001414 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 523791001415 substrate binding pocket [chemical binding]; other site 523791001416 chain length determination region; other site 523791001417 substrate-Mg2+ binding site; other site 523791001418 catalytic residues [active] 523791001419 aspartate-rich region 1; other site 523791001420 active site lid residues [active] 523791001421 aspartate-rich region 2; other site 523791001422 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 523791001423 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 523791001424 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523791001425 active site 523791001426 HIGH motif; other site 523791001427 nucleotide binding site [chemical binding]; other site 523791001428 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 523791001429 KMSKS motif; other site 523791001430 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 523791001431 AsmA family; Region: AsmA; pfam05170 523791001432 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 523791001433 Uncharacterized conserved protein [Function unknown]; Region: COG3595 523791001434 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 523791001435 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523791001436 Methyltransferase domain; Region: Methyltransf_12; pfam08242 523791001437 ABC transporter ATPase component; Reviewed; Region: PRK11147 523791001438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791001439 Walker A/P-loop; other site 523791001440 ATP binding site [chemical binding]; other site 523791001441 Q-loop/lid; other site 523791001442 ABC transporter signature motif; other site 523791001443 Walker B; other site 523791001444 D-loop; other site 523791001445 H-loop/switch region; other site 523791001446 ABC transporter; Region: ABC_tran_2; pfam12848 523791001447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791001448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 523791001449 Smr domain; Region: Smr; pfam01713 523791001450 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 523791001451 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 523791001452 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 523791001453 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 523791001454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523791001455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791001456 ATP binding site [chemical binding]; other site 523791001457 Mg2+ binding site [ion binding]; other site 523791001458 G-X-G motif; other site 523791001459 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 523791001460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791001461 active site 523791001462 phosphorylation site [posttranslational modification] 523791001463 intermolecular recognition site; other site 523791001464 dimerization interface [polypeptide binding]; other site 523791001465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 523791001466 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 523791001467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523791001468 N-terminal plug; other site 523791001469 ligand-binding site [chemical binding]; other site 523791001470 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 523791001471 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 523791001472 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 523791001473 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 523791001474 DNA binding site [nucleotide binding] 523791001475 active site 523791001476 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 523791001477 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 523791001478 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 523791001479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791001480 Walker A motif; other site 523791001481 ATP binding site [chemical binding]; other site 523791001482 Walker B motif; other site 523791001483 arginine finger; other site 523791001484 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 523791001485 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 523791001486 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 523791001487 GTPase RsgA; Reviewed; Region: PRK12288 523791001488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523791001489 RNA binding site [nucleotide binding]; other site 523791001490 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 523791001491 GTPase/Zn-binding domain interface [polypeptide binding]; other site 523791001492 GTP/Mg2+ binding site [chemical binding]; other site 523791001493 G4 box; other site 523791001494 G5 box; other site 523791001495 G1 box; other site 523791001496 Switch I region; other site 523791001497 G2 box; other site 523791001498 G3 box; other site 523791001499 Switch II region; other site 523791001500 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 523791001501 aromatic arch; other site 523791001502 DCoH dimer interaction site [polypeptide binding]; other site 523791001503 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 523791001504 DCoH tetramer interaction site [polypeptide binding]; other site 523791001505 substrate binding site [chemical binding]; other site 523791001506 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 523791001507 catalytic site [active] 523791001508 putative active site [active] 523791001509 putative substrate binding site [chemical binding]; other site 523791001510 dimer interface [polypeptide binding]; other site 523791001511 putative carbohydrate kinase; Provisional; Region: PRK10565 523791001512 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 523791001513 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 523791001514 putative substrate binding site [chemical binding]; other site 523791001515 putative ATP binding site [chemical binding]; other site 523791001516 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 523791001517 AMIN domain; Region: AMIN; pfam11741 523791001518 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523791001519 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523791001520 active site 523791001521 metal binding site [ion binding]; metal-binding site 523791001522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791001523 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 523791001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791001525 ATP binding site [chemical binding]; other site 523791001526 Mg2+ binding site [ion binding]; other site 523791001527 G-X-G motif; other site 523791001528 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 523791001529 ATP binding site [chemical binding]; other site 523791001530 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 523791001531 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 523791001532 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 523791001533 bacterial Hfq-like; Region: Hfq; cd01716 523791001534 hexamer interface [polypeptide binding]; other site 523791001535 Sm1 motif; other site 523791001536 RNA binding site [nucleotide binding]; other site 523791001537 Sm2 motif; other site 523791001538 GTPase HflX; Provisional; Region: PRK11058 523791001539 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 523791001540 HflX GTPase family; Region: HflX; cd01878 523791001541 G1 box; other site 523791001542 GTP/Mg2+ binding site [chemical binding]; other site 523791001543 Switch I region; other site 523791001544 G2 box; other site 523791001545 G3 box; other site 523791001546 Switch II region; other site 523791001547 G4 box; other site 523791001548 G5 box; other site 523791001549 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 523791001550 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 523791001551 HflK protein; Region: hflK; TIGR01933 523791001552 FtsH protease regulator HflC; Provisional; Region: PRK11029 523791001553 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 523791001554 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 523791001555 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 523791001556 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 523791001557 GDP-binding site [chemical binding]; other site 523791001558 ACT binding site; other site 523791001559 IMP binding site; other site 523791001560 Predicted membrane protein [Function unknown]; Region: COG2311 523791001561 Protein of unknown function (DUF418); Region: DUF418; cl12135 523791001562 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 523791001563 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 523791001564 putative active site [active] 523791001565 metal binding site [ion binding]; metal-binding site 523791001566 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 523791001567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523791001568 DoxX-like family; Region: DoxX_3; pfam13781 523791001569 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 523791001570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791001571 NAD(P) binding site [chemical binding]; other site 523791001572 elongation factor P; Provisional; Region: PRK04542 523791001573 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 523791001574 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 523791001575 RNA binding site [nucleotide binding]; other site 523791001576 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 523791001577 RNA binding site [nucleotide binding]; other site 523791001578 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 523791001579 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 523791001580 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 523791001581 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 523791001582 Low-spin heme binding site [chemical binding]; other site 523791001583 Putative water exit pathway; other site 523791001584 Binuclear center (active site) [active] 523791001585 Putative proton exit pathway; other site 523791001586 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 523791001587 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 523791001588 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 523791001589 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 523791001590 Cobalt transport protein component CbiN; Region: CbiN; cl00842 523791001591 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 523791001592 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 523791001593 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 523791001594 4Fe-4S binding domain; Region: Fer4_5; pfam12801 523791001595 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 523791001596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 523791001597 FixH; Region: FixH; pfam05751 523791001598 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 523791001599 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523791001600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791001601 metal-binding site [ion binding] 523791001602 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523791001603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791001604 motif II; other site 523791001605 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 523791001606 Family description; Region: DsbD_2; pfam13386 523791001607 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 523791001608 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523791001609 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523791001610 argininosuccinate synthase; Provisional; Region: PRK04527 523791001611 argininosuccinate synthase; Provisional; Region: PRK13820 523791001612 acetylornithine deacetylase; Provisional; Region: PRK08737 523791001613 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 523791001614 metal binding site [ion binding]; metal-binding site 523791001615 acetylglutamate kinase; Provisional; Region: PRK04531 523791001616 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 523791001617 nucleotide binding site [chemical binding]; other site 523791001618 substrate binding site [chemical binding]; other site 523791001619 Protein of unknown function (DUF619); Region: DUF619; pfam04768 523791001620 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 523791001621 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 523791001622 argininosuccinate lyase; Provisional; Region: PRK00855 523791001623 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 523791001624 active sites [active] 523791001625 tetramer interface [polypeptide binding]; other site 523791001626 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 523791001627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791001628 FeS/SAM binding site; other site 523791001629 HemN C-terminal domain; Region: HemN_C; pfam06969 523791001630 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 523791001631 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 523791001632 ligand binding site [chemical binding]; other site 523791001633 flexible hinge region; other site 523791001634 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 523791001635 putative switch regulator; other site 523791001636 non-specific DNA interactions [nucleotide binding]; other site 523791001637 DNA binding site [nucleotide binding] 523791001638 sequence specific DNA binding site [nucleotide binding]; other site 523791001639 putative cAMP binding site [chemical binding]; other site 523791001640 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 523791001641 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 523791001642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791001643 S-adenosylmethionine binding site [chemical binding]; other site 523791001644 DinB family; Region: DinB; cl17821 523791001645 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 523791001646 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 523791001647 putative ribose interaction site [chemical binding]; other site 523791001648 putative ADP binding site [chemical binding]; other site 523791001649 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 523791001650 active site 523791001651 nucleotide binding site [chemical binding]; other site 523791001652 HIGH motif; other site 523791001653 KMSKS motif; other site 523791001654 exoribonuclease R; Provisional; Region: PRK11642 523791001655 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 523791001656 RNB domain; Region: RNB; pfam00773 523791001657 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 523791001658 RNA binding site [nucleotide binding]; other site 523791001659 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 523791001660 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 523791001661 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523791001662 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 523791001663 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 523791001664 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 523791001665 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 523791001666 putative active site [active] 523791001667 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 523791001668 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 523791001669 asparagine synthetase AsnA; Provisional; Region: PRK05425 523791001670 motif 1; other site 523791001671 dimer interface [polypeptide binding]; other site 523791001672 active site 523791001673 motif 2; other site 523791001674 motif 3; other site 523791001675 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 523791001676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523791001677 putative DNA binding site [nucleotide binding]; other site 523791001678 putative Zn2+ binding site [ion binding]; other site 523791001679 AsnC family; Region: AsnC_trans_reg; pfam01037 523791001680 Pilin (bacterial filament); Region: Pilin; pfam00114 523791001681 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 523791001682 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 523791001683 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 523791001684 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 523791001685 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 523791001686 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 523791001687 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 523791001688 replicative DNA helicase; Region: DnaB; TIGR00665 523791001689 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 523791001690 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 523791001691 Walker A motif; other site 523791001692 ATP binding site [chemical binding]; other site 523791001693 Walker B motif; other site 523791001694 DNA binding loops [nucleotide binding] 523791001695 alanine racemase; Reviewed; Region: alr; PRK00053 523791001696 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 523791001697 active site 523791001698 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523791001699 substrate binding site [chemical binding]; other site 523791001700 catalytic residues [active] 523791001701 dimer interface [polypeptide binding]; other site 523791001702 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 523791001703 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 523791001704 heat shock protein HtpX; Provisional; Region: PRK05457 523791001705 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 523791001706 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 523791001707 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 523791001708 FMN binding site [chemical binding]; other site 523791001709 active site 523791001710 catalytic residues [active] 523791001711 substrate binding site [chemical binding]; other site 523791001712 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 523791001713 putative hydrophobic ligand binding site [chemical binding]; other site 523791001714 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 523791001715 dimerization interface [polypeptide binding]; other site 523791001716 substrate binding site [chemical binding]; other site 523791001717 active site 523791001718 calcium binding site [ion binding]; other site 523791001719 hypothetical protein; Provisional; Region: PRK07907 523791001720 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 523791001721 metal binding site [ion binding]; metal-binding site 523791001722 putative dimer interface [polypeptide binding]; other site 523791001723 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 523791001724 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 523791001725 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 523791001726 Protein of unknown function (DUF461); Region: DUF461; pfam04314 523791001727 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 523791001728 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 523791001729 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 523791001730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791001731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791001732 DNA binding residues [nucleotide binding] 523791001733 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 523791001734 dimer interface [polypeptide binding]; other site 523791001735 substrate binding site [chemical binding]; other site 523791001736 metal binding sites [ion binding]; metal-binding site 523791001737 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 523791001738 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 523791001739 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 523791001740 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 523791001741 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 523791001742 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791001743 6-phosphofructokinase; Provisional; Region: PRK14072 523791001744 active site 523791001745 ADP/pyrophosphate binding site [chemical binding]; other site 523791001746 dimerization interface [polypeptide binding]; other site 523791001747 allosteric effector site; other site 523791001748 fructose-1,6-bisphosphate binding site; other site 523791001749 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 523791001750 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523791001751 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791001752 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791001753 aromatic acid decarboxylase; Validated; Region: PRK05920 523791001754 Flavoprotein; Region: Flavoprotein; pfam02441 523791001755 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523791001756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791001757 Walker A/P-loop; other site 523791001758 ATP binding site [chemical binding]; other site 523791001759 Q-loop/lid; other site 523791001760 ABC transporter signature motif; other site 523791001761 Walker B; other site 523791001762 D-loop; other site 523791001763 H-loop/switch region; other site 523791001764 inner membrane transport permease; Provisional; Region: PRK15066 523791001765 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 523791001766 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 523791001767 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 523791001768 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 523791001769 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 523791001770 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 523791001771 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 523791001772 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 523791001773 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 523791001774 Sulfatase; Region: Sulfatase; pfam00884 523791001775 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 523791001776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 523791001777 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 523791001778 DNA binding residues [nucleotide binding] 523791001779 dimerization interface [polypeptide binding]; other site 523791001780 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 523791001781 metal ion-dependent adhesion site (MIDAS); other site 523791001782 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 523791001783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791001784 S-adenosylmethionine binding site [chemical binding]; other site 523791001785 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 523791001786 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 523791001787 putative NAD(P) binding site [chemical binding]; other site 523791001788 putative substrate binding site [chemical binding]; other site 523791001789 catalytic Zn binding site [ion binding]; other site 523791001790 structural Zn binding site [ion binding]; other site 523791001791 dimer interface [polypeptide binding]; other site 523791001792 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 523791001793 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523791001794 ATP binding site [chemical binding]; other site 523791001795 Mg++ binding site [ion binding]; other site 523791001796 motif III; other site 523791001797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791001798 nucleotide binding region [chemical binding]; other site 523791001799 ATP-binding site [chemical binding]; other site 523791001800 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 523791001801 putative RNA binding site [nucleotide binding]; other site 523791001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791001803 AAA domain; Region: AAA_21; pfam13304 523791001804 Walker A/P-loop; other site 523791001805 ATP binding site [chemical binding]; other site 523791001806 Q-loop/lid; other site 523791001807 RloB-like protein; Region: RloB; pfam13707 523791001808 GTP-binding protein YchF; Reviewed; Region: PRK09601 523791001809 YchF GTPase; Region: YchF; cd01900 523791001810 G1 box; other site 523791001811 GTP/Mg2+ binding site [chemical binding]; other site 523791001812 Switch I region; other site 523791001813 G2 box; other site 523791001814 Switch II region; other site 523791001815 G3 box; other site 523791001816 G4 box; other site 523791001817 G5 box; other site 523791001818 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 523791001819 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 523791001820 putative active site [active] 523791001821 catalytic residue [active] 523791001822 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 523791001823 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 523791001824 5S rRNA interface [nucleotide binding]; other site 523791001825 CTC domain interface [polypeptide binding]; other site 523791001826 L16 interface [polypeptide binding]; other site 523791001827 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 523791001828 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523791001829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791001830 active site 523791001831 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 523791001832 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523791001833 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 523791001834 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 523791001835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791001836 binding surface 523791001837 TPR motif; other site 523791001838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791001839 TPR motif; other site 523791001840 binding surface 523791001841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791001842 binding surface 523791001843 TPR motif; other site 523791001844 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 523791001845 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 523791001846 tRNA; other site 523791001847 putative tRNA binding site [nucleotide binding]; other site 523791001848 putative NADP binding site [chemical binding]; other site 523791001849 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 523791001850 peptide chain release factor 1; Validated; Region: prfA; PRK00591 523791001851 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523791001852 RF-1 domain; Region: RF-1; pfam00472 523791001853 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 523791001854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791001855 S-adenosylmethionine binding site [chemical binding]; other site 523791001856 rod shape-determining protein MreB; Provisional; Region: PRK13927 523791001857 MreB and similar proteins; Region: MreB_like; cd10225 523791001858 nucleotide binding site [chemical binding]; other site 523791001859 Mg binding site [ion binding]; other site 523791001860 putative protofilament interaction site [polypeptide binding]; other site 523791001861 RodZ interaction site [polypeptide binding]; other site 523791001862 rod shape-determining protein MreC; Region: mreC; TIGR00219 523791001863 rod shape-determining protein MreC; Region: MreC; pfam04085 523791001864 rod shape-determining protein MreD; Region: MreD; cl01087 523791001865 Maf-like protein; Region: Maf; pfam02545 523791001866 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 523791001867 active site 523791001868 dimer interface [polypeptide binding]; other site 523791001869 ribonuclease G; Provisional; Region: PRK11712 523791001870 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 523791001871 homodimer interface [polypeptide binding]; other site 523791001872 oligonucleotide binding site [chemical binding]; other site 523791001873 TIGR02099 family protein; Region: TIGR02099 523791001874 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 523791001875 nitrilase; Region: PLN02798 523791001876 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 523791001877 putative active site [active] 523791001878 catalytic triad [active] 523791001879 dimer interface [polypeptide binding]; other site 523791001880 protease TldD; Provisional; Region: tldD; PRK10735 523791001881 hypothetical protein; Provisional; Region: PRK05255 523791001882 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791001883 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791001884 peptidase PmbA; Provisional; Region: PRK11040 523791001885 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 523791001886 MgtE intracellular N domain; Region: MgtE_N; smart00924 523791001887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 523791001888 Divalent cation transporter; Region: MgtE; pfam01769 523791001889 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 523791001890 AAA domain; Region: AAA_18; pfam13238 523791001891 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523791001892 active site 523791001893 phosphorylation site [posttranslational modification] 523791001894 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 523791001895 30S subunit binding site; other site 523791001896 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 523791001897 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 523791001898 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 523791001899 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 523791001900 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 523791001901 Walker A/P-loop; other site 523791001902 ATP binding site [chemical binding]; other site 523791001903 Q-loop/lid; other site 523791001904 ABC transporter signature motif; other site 523791001905 Walker B; other site 523791001906 D-loop; other site 523791001907 H-loop/switch region; other site 523791001908 OstA-like protein; Region: OstA; cl00844 523791001909 OstA-like protein; Region: OstA; cl00844 523791001910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 523791001911 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 523791001912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791001913 active site 523791001914 motif I; other site 523791001915 motif II; other site 523791001916 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 523791001917 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 523791001918 putative active site [active] 523791001919 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 523791001920 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 523791001921 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 523791001922 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 523791001923 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 523791001924 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 523791001925 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 523791001926 hinge; other site 523791001927 active site 523791001928 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 523791001929 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523791001930 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523791001931 protein binding site [polypeptide binding]; other site 523791001932 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 523791001933 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 523791001934 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 523791001935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791001936 Predicted ATPase [General function prediction only]; Region: COG1485 523791001937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791001938 Walker A/P-loop; other site 523791001939 ATP binding site [chemical binding]; other site 523791001940 ABC transporter signature motif; other site 523791001941 Walker B; other site 523791001942 D-loop; other site 523791001943 H-loop/switch region; other site 523791001944 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523791001945 IHF dimer interface [polypeptide binding]; other site 523791001946 IHF - DNA interface [nucleotide binding]; other site 523791001947 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 523791001948 23S rRNA interface [nucleotide binding]; other site 523791001949 L3 interface [polypeptide binding]; other site 523791001950 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 523791001951 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 523791001952 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 523791001953 [2Fe-2S] cluster binding site [ion binding]; other site 523791001954 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 523791001955 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 523791001956 Qi binding site; other site 523791001957 intrachain domain interface; other site 523791001958 interchain domain interface [polypeptide binding]; other site 523791001959 heme bH binding site [chemical binding]; other site 523791001960 heme bL binding site [chemical binding]; other site 523791001961 Qo binding site; other site 523791001962 interchain domain interface [polypeptide binding]; other site 523791001963 intrachain domain interface; other site 523791001964 Qi binding site; other site 523791001965 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 523791001966 Qo binding site; other site 523791001967 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 523791001968 stringent starvation protein A; Provisional; Region: sspA; PRK09481 523791001969 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 523791001970 C-terminal domain interface [polypeptide binding]; other site 523791001971 putative GSH binding site (G-site) [chemical binding]; other site 523791001972 dimer interface [polypeptide binding]; other site 523791001973 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 523791001974 dimer interface [polypeptide binding]; other site 523791001975 N-terminal domain interface [polypeptide binding]; other site 523791001976 Stringent starvation protein B; Region: SspB; cl01120 523791001977 outer membrane lipoprotein; Provisional; Region: PRK11023 523791001978 BON domain; Region: BON; pfam04972 523791001979 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 523791001980 dimer interface [polypeptide binding]; other site 523791001981 active site 523791001982 hypothetical protein; Reviewed; Region: PRK12497 523791001983 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 523791001984 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 523791001985 putative ligand binding site [chemical binding]; other site 523791001986 Predicted methyltransferases [General function prediction only]; Region: COG0313 523791001987 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 523791001988 putative SAM binding site [chemical binding]; other site 523791001989 putative homodimer interface [polypeptide binding]; other site 523791001990 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 523791001991 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 523791001992 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 523791001993 glutaminase; Provisional; Region: PRK00971 523791001994 cell division protein MraZ; Reviewed; Region: PRK00326 523791001995 MraZ protein; Region: MraZ; pfam02381 523791001996 MraZ protein; Region: MraZ; pfam02381 523791001997 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 523791001998 MraW methylase family; Region: Methyltransf_5; pfam01795 523791001999 Cell division protein FtsL; Region: FtsL; pfam04999 523791002000 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 523791002001 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 523791002002 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523791002003 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 523791002004 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523791002005 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791002006 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791002007 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 523791002008 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523791002009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791002010 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791002011 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 523791002012 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 523791002013 Mg++ binding site [ion binding]; other site 523791002014 putative catalytic motif [active] 523791002015 putative substrate binding site [chemical binding]; other site 523791002016 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 523791002017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791002018 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791002019 cell division protein FtsW; Region: ftsW; TIGR02614 523791002020 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 523791002021 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 523791002022 active site 523791002023 homodimer interface [polypeptide binding]; other site 523791002024 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 523791002025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523791002026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791002027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791002028 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 523791002029 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 523791002030 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523791002031 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 523791002032 Cell division protein FtsQ; Region: FtsQ; pfam03799 523791002033 cell division protein FtsA; Region: ftsA; TIGR01174 523791002034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523791002035 nucleotide binding site [chemical binding]; other site 523791002036 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 523791002037 Cell division protein FtsA; Region: FtsA; pfam14450 523791002038 cell division protein FtsZ; Validated; Region: PRK09330 523791002039 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 523791002040 nucleotide binding site [chemical binding]; other site 523791002041 SulA interaction site; other site 523791002042 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 523791002043 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 523791002044 Protein of unknown function (DUF721); Region: DUF721; pfam05258 523791002045 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523791002046 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791002047 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 523791002048 DEAD/DEAH box helicase; Region: DEAD; pfam00270 523791002049 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 523791002050 SEC-C motif; Region: SEC-C; pfam02810 523791002051 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 523791002052 active site 523791002053 8-oxo-dGMP binding site [chemical binding]; other site 523791002054 nudix motif; other site 523791002055 metal binding site [ion binding]; metal-binding site 523791002056 Domain of unknown function (DUF329); Region: DUF329; pfam03884 523791002057 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 523791002058 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 523791002059 amidase catalytic site [active] 523791002060 Zn binding residues [ion binding]; other site 523791002061 substrate binding site [chemical binding]; other site 523791002062 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 523791002063 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 523791002064 dimerization interface [polypeptide binding]; other site 523791002065 active site 523791002066 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 523791002067 GIY-YIG motif/motif A; other site 523791002068 putative active site [active] 523791002069 putative metal binding site [ion binding]; other site 523791002070 Pilin (bacterial filament); Region: Pilin; pfam00114 523791002071 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 523791002072 O-Antigen ligase; Region: Wzy_C; cl04850 523791002073 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 523791002074 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 523791002075 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 523791002076 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 523791002077 Walker A motif; other site 523791002078 ATP binding site [chemical binding]; other site 523791002079 Walker B motif; other site 523791002080 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 523791002081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523791002082 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523791002083 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 523791002084 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 523791002085 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 523791002086 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 523791002087 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 523791002088 CoA-binding site [chemical binding]; other site 523791002089 ATP-binding [chemical binding]; other site 523791002090 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 523791002091 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 523791002092 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 523791002093 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 523791002094 dimer interface [polypeptide binding]; other site 523791002095 TPP-binding site [chemical binding]; other site 523791002096 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 523791002097 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791002098 E3 interaction surface; other site 523791002099 lipoyl attachment site [posttranslational modification]; other site 523791002100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791002101 E3 interaction surface; other site 523791002102 lipoyl attachment site [posttranslational modification]; other site 523791002103 e3 binding domain; Region: E3_binding; pfam02817 523791002104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523791002105 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 523791002106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791002107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523791002108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523791002109 EamA-like transporter family; Region: EamA; pfam00892 523791002110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 523791002111 EamA-like transporter family; Region: EamA; pfam00892 523791002112 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 523791002113 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523791002114 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791002115 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 523791002116 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 523791002117 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 523791002118 active site 523791002119 Zn binding site [ion binding]; other site 523791002120 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523791002121 active site 523791002122 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 523791002123 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 523791002124 Ligand Binding Site [chemical binding]; other site 523791002125 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 523791002126 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 523791002127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002128 S-adenosylmethionine binding site [chemical binding]; other site 523791002129 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 523791002130 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 523791002131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 523791002132 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 523791002133 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 523791002134 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 523791002135 Flavodoxin; Region: Flavodoxin_1; pfam00258 523791002136 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 523791002137 FAD binding pocket [chemical binding]; other site 523791002138 FAD binding motif [chemical binding]; other site 523791002139 catalytic residues [active] 523791002140 NAD binding pocket [chemical binding]; other site 523791002141 phosphate binding motif [ion binding]; other site 523791002142 beta-alpha-beta structure motif; other site 523791002143 sulfite reductase subunit beta; Provisional; Region: PRK13504 523791002144 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523791002145 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523791002146 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 523791002147 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 523791002148 Active Sites [active] 523791002149 siroheme synthase; Provisional; Region: cysG; PRK10637 523791002150 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 523791002151 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 523791002152 active site 523791002153 SAM binding site [chemical binding]; other site 523791002154 homodimer interface [polypeptide binding]; other site 523791002155 POT family; Region: PTR2; cl17359 523791002156 POT family; Region: PTR2; cl17359 523791002157 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 523791002158 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 523791002159 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 523791002160 NADP binding site [chemical binding]; other site 523791002161 dimer interface [polypeptide binding]; other site 523791002162 probable DNA repair protein; Region: TIGR03623 523791002163 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 523791002164 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 523791002165 Part of AAA domain; Region: AAA_19; pfam13245 523791002166 Family description; Region: UvrD_C_2; pfam13538 523791002167 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 523791002168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791002169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523791002170 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 523791002171 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 523791002172 CoenzymeA binding site [chemical binding]; other site 523791002173 subunit interaction site [polypeptide binding]; other site 523791002174 PHB binding site; other site 523791002175 peptide chain release factor 2; Validated; Region: prfB; PRK00578 523791002176 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523791002177 RF-1 domain; Region: RF-1; pfam00472 523791002178 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 523791002179 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 523791002180 dimer interface [polypeptide binding]; other site 523791002181 putative anticodon binding site; other site 523791002182 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 523791002183 motif 1; other site 523791002184 active site 523791002185 motif 2; other site 523791002186 motif 3; other site 523791002187 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 523791002188 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 523791002189 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 523791002190 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791002191 putative catalytic residues [active] 523791002192 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 523791002193 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 523791002194 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 523791002195 Uncharacterized conserved protein [Function unknown]; Region: COG2938 523791002196 L-aspartate oxidase; Provisional; Region: PRK09077 523791002197 L-aspartate oxidase; Provisional; Region: PRK06175 523791002198 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 523791002199 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 523791002200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791002201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791002202 DNA binding residues [nucleotide binding] 523791002203 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 523791002204 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 523791002205 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 523791002206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523791002207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523791002208 protein binding site [polypeptide binding]; other site 523791002209 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523791002210 protein binding site [polypeptide binding]; other site 523791002211 GTP-binding protein LepA; Provisional; Region: PRK05433 523791002212 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 523791002213 G1 box; other site 523791002214 putative GEF interaction site [polypeptide binding]; other site 523791002215 GTP/Mg2+ binding site [chemical binding]; other site 523791002216 Switch I region; other site 523791002217 G2 box; other site 523791002218 G3 box; other site 523791002219 Switch II region; other site 523791002220 G4 box; other site 523791002221 G5 box; other site 523791002222 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 523791002223 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 523791002224 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 523791002225 signal peptidase I; Provisional; Region: PRK10861 523791002226 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523791002227 Catalytic site [active] 523791002228 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523791002229 ribonuclease III; Reviewed; Region: rnc; PRK00102 523791002230 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 523791002231 dimerization interface [polypeptide binding]; other site 523791002232 active site 523791002233 metal binding site [ion binding]; metal-binding site 523791002234 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 523791002235 dsRNA binding site [nucleotide binding]; other site 523791002236 GTPase Era; Reviewed; Region: era; PRK00089 523791002237 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 523791002238 G1 box; other site 523791002239 GTP/Mg2+ binding site [chemical binding]; other site 523791002240 Switch I region; other site 523791002241 G2 box; other site 523791002242 Switch II region; other site 523791002243 G3 box; other site 523791002244 G4 box; other site 523791002245 G5 box; other site 523791002246 KH domain; Region: KH_2; pfam07650 523791002247 Recombination protein O N terminal; Region: RecO_N; pfam11967 523791002248 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 523791002249 Recombination protein O C terminal; Region: RecO_C; pfam02565 523791002250 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 523791002251 active site 523791002252 hydrophilic channel; other site 523791002253 dimerization interface [polypeptide binding]; other site 523791002254 catalytic residues [active] 523791002255 active site lid [active] 523791002256 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 523791002257 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 523791002258 short chain dehydrogenase; Provisional; Region: PRK08278 523791002259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791002260 NAD(P) binding site [chemical binding]; other site 523791002261 active site 523791002262 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 523791002263 catalytic residues [active] 523791002264 dimer interface [polypeptide binding]; other site 523791002265 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 523791002266 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 523791002267 PA/protease or protease-like domain interface [polypeptide binding]; other site 523791002268 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 523791002269 Peptidase family M28; Region: Peptidase_M28; pfam04389 523791002270 metal binding site [ion binding]; metal-binding site 523791002271 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 523791002272 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 523791002273 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 523791002274 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507 523791002275 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 523791002276 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 523791002277 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 523791002278 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 523791002279 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791002280 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 523791002281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791002282 type III secretion system protein SpaS; Validated; Region: PRK08156 523791002283 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 523791002284 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 523791002285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791002286 DNA binding site [nucleotide binding] 523791002287 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 523791002288 fatty acid metabolism regulator; Provisional; Region: PRK04984 523791002289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523791002290 DNA-binding site [nucleotide binding]; DNA binding site 523791002291 FadR C-terminal domain; Region: FadR_C; pfam07840 523791002292 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 523791002293 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 523791002294 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 523791002295 putative inner membrane peptidase; Provisional; Region: PRK11778 523791002296 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 523791002297 tandem repeat interface [polypeptide binding]; other site 523791002298 oligomer interface [polypeptide binding]; other site 523791002299 active site residues [active] 523791002300 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 523791002301 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523791002302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791002303 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 523791002304 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 523791002305 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 523791002306 Penicillinase repressor; Region: Pencillinase_R; pfam03965 523791002307 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 523791002308 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 523791002309 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791002310 succinylarginine dihydrolase; Provisional; Region: PRK13281 523791002311 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 523791002312 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 523791002313 NAD(P) binding site [chemical binding]; other site 523791002314 catalytic residues [active] 523791002315 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 523791002316 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 523791002317 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 523791002318 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523791002319 inhibitor-cofactor binding pocket; inhibition site 523791002320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791002321 catalytic residue [active] 523791002322 OmpW family; Region: OmpW; cl17427 523791002323 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 523791002324 active site 523791002325 catalytic triad [active] 523791002326 oxyanion hole [active] 523791002327 switch loop; other site 523791002328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523791002329 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 523791002330 Walker A/P-loop; other site 523791002331 ATP binding site [chemical binding]; other site 523791002332 Q-loop/lid; other site 523791002333 ABC transporter signature motif; other site 523791002334 Walker B; other site 523791002335 D-loop; other site 523791002336 H-loop/switch region; other site 523791002337 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 523791002338 FtsX-like permease family; Region: FtsX; pfam02687 523791002339 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 523791002340 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 523791002341 active site 523791002342 interdomain interaction site; other site 523791002343 putative metal-binding site [ion binding]; other site 523791002344 nucleotide binding site [chemical binding]; other site 523791002345 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 523791002346 domain I; other site 523791002347 DNA binding groove [nucleotide binding] 523791002348 phosphate binding site [ion binding]; other site 523791002349 domain II; other site 523791002350 domain III; other site 523791002351 nucleotide binding site [chemical binding]; other site 523791002352 catalytic site [active] 523791002353 domain IV; other site 523791002354 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 523791002355 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 523791002356 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 523791002357 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 523791002358 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 523791002359 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 523791002360 quinone interaction residues [chemical binding]; other site 523791002361 active site 523791002362 catalytic residues [active] 523791002363 FMN binding site [chemical binding]; other site 523791002364 substrate binding site [chemical binding]; other site 523791002365 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 523791002366 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 523791002367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 523791002368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002369 S-adenosylmethionine binding site [chemical binding]; other site 523791002370 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 523791002371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523791002372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791002373 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 523791002374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523791002375 active site 523791002376 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 523791002377 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 523791002378 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 523791002379 active site 523791002380 catalytic residues [active] 523791002381 metal binding site [ion binding]; metal-binding site 523791002382 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 523791002383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791002384 Coenzyme A binding pocket [chemical binding]; other site 523791002385 PAS fold; Region: PAS_4; pfam08448 523791002386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791002387 putative active site [active] 523791002388 heme pocket [chemical binding]; other site 523791002389 GAF domain; Region: GAF_2; pfam13185 523791002390 GAF domain; Region: GAF; cl17456 523791002391 PAS domain S-box; Region: sensory_box; TIGR00229 523791002392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791002393 putative active site [active] 523791002394 heme pocket [chemical binding]; other site 523791002395 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791002396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791002397 metal binding site [ion binding]; metal-binding site 523791002398 active site 523791002399 I-site; other site 523791002400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791002401 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523791002402 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523791002403 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 523791002404 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 523791002405 G1 box; other site 523791002406 putative GEF interaction site [polypeptide binding]; other site 523791002407 GTP/Mg2+ binding site [chemical binding]; other site 523791002408 Switch I region; other site 523791002409 G2 box; other site 523791002410 G3 box; other site 523791002411 Switch II region; other site 523791002412 G4 box; other site 523791002413 G5 box; other site 523791002414 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 523791002415 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 523791002416 active site 523791002417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791002418 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791002419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791002420 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791002421 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 523791002422 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 523791002423 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523791002424 Walker A motif; other site 523791002425 ATP binding site [chemical binding]; other site 523791002426 Walker B motif; other site 523791002427 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 523791002428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523791002429 substrate binding pocket [chemical binding]; other site 523791002430 membrane-bound complex binding site; other site 523791002431 hinge residues; other site 523791002432 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791002433 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791002434 catalytic residue [active] 523791002435 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 523791002436 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 523791002437 dimerization interface [polypeptide binding]; other site 523791002438 ATP binding site [chemical binding]; other site 523791002439 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 523791002440 dimerization interface [polypeptide binding]; other site 523791002441 ATP binding site [chemical binding]; other site 523791002442 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 523791002443 putative active site [active] 523791002444 catalytic triad [active] 523791002445 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 523791002446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791002447 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 523791002448 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 523791002449 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 523791002450 Na binding site [ion binding]; other site 523791002451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791002452 Coenzyme A binding pocket [chemical binding]; other site 523791002453 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 523791002454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791002455 ATP-grasp domain; Region: ATP-grasp; pfam02222 523791002456 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 523791002457 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 523791002458 putative dimer interface [polypeptide binding]; other site 523791002459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 523791002460 Ligand Binding Site [chemical binding]; other site 523791002461 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 523791002462 Protein export membrane protein; Region: SecD_SecF; cl14618 523791002463 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 523791002464 Domain of unknown function DUF21; Region: DUF21; pfam01595 523791002465 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523791002466 Transporter associated domain; Region: CorC_HlyC; smart01091 523791002467 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 523791002468 signal recognition particle protein; Provisional; Region: PRK10867 523791002469 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 523791002470 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523791002471 P loop; other site 523791002472 GTP binding site [chemical binding]; other site 523791002473 Signal peptide binding domain; Region: SRP_SPB; pfam02978 523791002474 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523791002475 Sel1-like repeats; Region: SEL1; smart00671 523791002476 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 523791002477 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 523791002478 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 523791002479 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 523791002480 RimM N-terminal domain; Region: RimM; pfam01782 523791002481 PRC-barrel domain; Region: PRC; pfam05239 523791002482 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 523791002483 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 523791002484 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 523791002485 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 523791002486 active site 523791002487 Int/Topo IB signature motif; other site 523791002488 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 523791002489 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 523791002490 dimerization domain [polypeptide binding]; other site 523791002491 dimer interface [polypeptide binding]; other site 523791002492 catalytic residues [active] 523791002493 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 523791002494 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 523791002495 DHH family; Region: DHH; pfam01368 523791002496 DHHA1 domain; Region: DHHA1; pfam02272 523791002497 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 523791002498 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523791002499 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 523791002500 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523791002501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791002502 FeS/SAM binding site; other site 523791002503 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 523791002504 HAMP domain; Region: HAMP; pfam00672 523791002505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791002506 dimer interface [polypeptide binding]; other site 523791002507 phosphorylation site [posttranslational modification] 523791002508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791002509 ATP binding site [chemical binding]; other site 523791002510 Mg2+ binding site [ion binding]; other site 523791002511 G-X-G motif; other site 523791002512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791002513 active site 523791002514 phosphorylation site [posttranslational modification] 523791002515 intermolecular recognition site; other site 523791002516 dimerization interface [polypeptide binding]; other site 523791002517 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 523791002518 putative binding surface; other site 523791002519 active site 523791002520 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 523791002521 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 523791002522 active site 523791002523 catalytic site [active] 523791002524 substrate binding site [chemical binding]; other site 523791002525 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 523791002526 TRAM domain; Region: TRAM; cl01282 523791002527 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 523791002528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002529 S-adenosylmethionine binding site [chemical binding]; other site 523791002530 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 523791002531 ZIP Zinc transporter; Region: Zip; pfam02535 523791002532 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 523791002533 HD domain; Region: HD_4; pfam13328 523791002534 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523791002535 synthetase active site [active] 523791002536 NTP binding site [chemical binding]; other site 523791002537 metal binding site [ion binding]; metal-binding site 523791002538 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 523791002539 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 523791002540 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 523791002541 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 523791002542 homodimer interface [polypeptide binding]; other site 523791002543 metal binding site [ion binding]; metal-binding site 523791002544 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 523791002545 homodimer interface [polypeptide binding]; other site 523791002546 active site 523791002547 putative chemical substrate binding site [chemical binding]; other site 523791002548 metal binding site [ion binding]; metal-binding site 523791002549 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 523791002550 CTP synthetase; Validated; Region: pyrG; PRK05380 523791002551 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 523791002552 Catalytic site [active] 523791002553 active site 523791002554 UTP binding site [chemical binding]; other site 523791002555 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 523791002556 active site 523791002557 putative oxyanion hole; other site 523791002558 catalytic triad [active] 523791002559 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 523791002560 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 523791002561 enolase; Provisional; Region: eno; PRK00077 523791002562 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 523791002563 dimer interface [polypeptide binding]; other site 523791002564 metal binding site [ion binding]; metal-binding site 523791002565 substrate binding pocket [chemical binding]; other site 523791002566 Septum formation initiator; Region: DivIC; cl17659 523791002567 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 523791002568 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 523791002569 substrate binding site; other site 523791002570 dimer interface; other site 523791002571 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 523791002572 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 523791002573 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 523791002574 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 523791002575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523791002576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791002577 homodimer interface [polypeptide binding]; other site 523791002578 catalytic residue [active] 523791002579 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 523791002580 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 523791002581 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 523791002582 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 523791002583 putative active site pocket [active] 523791002584 4-fold oligomerization interface [polypeptide binding]; other site 523791002585 metal binding residues [ion binding]; metal-binding site 523791002586 3-fold/trimer interface [polypeptide binding]; other site 523791002587 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 523791002588 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 523791002589 putative active site [active] 523791002590 oxyanion strand; other site 523791002591 catalytic triad [active] 523791002592 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 523791002593 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 523791002594 substrate binding site [chemical binding]; other site 523791002595 glutamase interaction surface [polypeptide binding]; other site 523791002596 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 523791002597 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 523791002598 catalytic residues [active] 523791002599 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 523791002600 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 523791002601 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in His4-like fungal histidine biosynthesis trifunctional proteins and their homologs; Region: NTP-PPase_His4; cd11546 523791002602 metal binding site [ion binding]; metal-binding site 523791002603 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 523791002604 histidinol dehydrogenase; Region: hisD; TIGR00069 523791002605 NAD binding site [chemical binding]; other site 523791002606 dimerization interface [polypeptide binding]; other site 523791002607 product binding site; other site 523791002608 substrate binding site [chemical binding]; other site 523791002609 zinc binding site [ion binding]; other site 523791002610 catalytic residues [active] 523791002611 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 523791002612 homotrimer interaction site [polypeptide binding]; other site 523791002613 zinc binding site [ion binding]; other site 523791002614 CDP-binding sites; other site 523791002615 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 523791002616 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 523791002617 Permutation of conserved domain; other site 523791002618 active site 523791002619 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 523791002620 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 523791002621 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 523791002622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002623 S-adenosylmethionine binding site [chemical binding]; other site 523791002624 Predicted membrane protein [Function unknown]; Region: COG1238 523791002625 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 523791002626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791002627 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791002628 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 523791002629 YciI-like protein; Reviewed; Region: PRK11370 523791002630 Intracellular septation protein A; Region: IspA; cl01098 523791002631 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 523791002632 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 523791002633 active site 523791002634 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 523791002635 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 523791002636 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 523791002637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791002638 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 523791002639 putative dimer interface [polypeptide binding]; other site 523791002640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791002641 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 523791002642 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 523791002643 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523791002644 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 523791002645 N-terminal domain interface [polypeptide binding]; other site 523791002646 dimer interface [polypeptide binding]; other site 523791002647 substrate binding pocket (H-site) [chemical binding]; other site 523791002648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523791002649 MarR family; Region: MarR; pfam01047 523791002650 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 523791002651 active site 523791002652 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 523791002653 HIGH motif; other site 523791002654 dimer interface [polypeptide binding]; other site 523791002655 KMSKS motif; other site 523791002656 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 523791002657 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 523791002658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 523791002659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791002660 active site 523791002661 phosphorylation site [posttranslational modification] 523791002662 intermolecular recognition site; other site 523791002663 dimerization interface [polypeptide binding]; other site 523791002664 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 523791002665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791002666 RNA binding surface [nucleotide binding]; other site 523791002667 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 523791002668 probable active site [active] 523791002669 polyphosphate kinase; Provisional; Region: PRK05443 523791002670 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 523791002671 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 523791002672 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 523791002673 putative domain interface [polypeptide binding]; other site 523791002674 putative active site [active] 523791002675 catalytic site [active] 523791002676 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 523791002677 putative domain interface [polypeptide binding]; other site 523791002678 putative active site [active] 523791002679 catalytic site [active] 523791002680 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 523791002681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523791002682 nucleotide binding site [chemical binding]; other site 523791002683 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 523791002684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791002685 NAD(P) binding site [chemical binding]; other site 523791002686 active site 523791002687 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 523791002688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791002689 active site 523791002690 phosphorylation site [posttranslational modification] 523791002691 intermolecular recognition site; other site 523791002692 dimerization interface [polypeptide binding]; other site 523791002693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791002694 DNA binding site [nucleotide binding] 523791002695 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 523791002696 putative ligand binding site [chemical binding]; other site 523791002697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791002698 dimer interface [polypeptide binding]; other site 523791002699 phosphorylation site [posttranslational modification] 523791002700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791002701 ATP binding site [chemical binding]; other site 523791002702 Mg2+ binding site [ion binding]; other site 523791002703 G-X-G motif; other site 523791002704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 523791002705 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 523791002706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791002707 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 523791002708 putative active site [active] 523791002709 heme pocket [chemical binding]; other site 523791002710 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 523791002711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791002712 putative active site [active] 523791002713 heme pocket [chemical binding]; other site 523791002714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791002715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791002716 metal binding site [ion binding]; metal-binding site 523791002717 active site 523791002718 I-site; other site 523791002719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791002720 phosphoglycolate phosphatase; Provisional; Region: PRK13222 523791002721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791002722 motif II; other site 523791002723 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 523791002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002725 S-adenosylmethionine binding site [chemical binding]; other site 523791002726 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 523791002727 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 523791002728 active site 523791002729 putative substrate binding pocket [chemical binding]; other site 523791002730 DNA gyrase subunit A; Validated; Region: PRK05560 523791002731 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 523791002732 CAP-like domain; other site 523791002733 active site 523791002734 primary dimer interface [polypeptide binding]; other site 523791002735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002737 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002738 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002739 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002740 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523791002741 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 523791002742 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 523791002743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791002744 catalytic residue [active] 523791002745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 523791002746 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 523791002747 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 523791002748 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791002749 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 523791002750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523791002751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791002752 homodimer interface [polypeptide binding]; other site 523791002753 catalytic residue [active] 523791002754 cytidylate kinase; Provisional; Region: cmk; PRK00023 523791002755 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 523791002756 CMP-binding site; other site 523791002757 The sites determining sugar specificity; other site 523791002758 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 523791002759 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 523791002760 RNA binding site [nucleotide binding]; other site 523791002761 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 523791002762 RNA binding site [nucleotide binding]; other site 523791002763 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 523791002764 RNA binding site [nucleotide binding]; other site 523791002765 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 523791002766 RNA binding site [nucleotide binding]; other site 523791002767 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523791002768 RNA binding site [nucleotide binding]; other site 523791002769 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 523791002770 RNA binding site [nucleotide binding]; other site 523791002771 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523791002772 IHF dimer interface [polypeptide binding]; other site 523791002773 IHF - DNA interface [nucleotide binding]; other site 523791002774 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 523791002775 tetratricopeptide repeat protein; Provisional; Region: PRK11788 523791002776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523791002777 TPR motif; other site 523791002778 binding surface 523791002779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791002780 binding surface 523791002781 TPR motif; other site 523791002782 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 523791002783 active site 523791002784 dimer interface [polypeptide binding]; other site 523791002785 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 523791002786 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 523791002787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 523791002788 non-specific DNA binding site [nucleotide binding]; other site 523791002789 salt bridge; other site 523791002790 sequence-specific DNA binding site [nucleotide binding]; other site 523791002791 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 523791002792 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 523791002793 Sulfate transporter family; Region: Sulfate_transp; pfam00916 523791002794 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 523791002795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 523791002796 Ligand Binding Site [chemical binding]; other site 523791002797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 523791002798 Ligand Binding Site [chemical binding]; other site 523791002799 aspartate aminotransferase; Provisional; Region: PRK05764 523791002800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523791002801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791002802 homodimer interface [polypeptide binding]; other site 523791002803 catalytic residue [active] 523791002804 excinuclease ABC subunit B; Provisional; Region: PRK05298 523791002805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523791002806 ATP binding site [chemical binding]; other site 523791002807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791002808 nucleotide binding region [chemical binding]; other site 523791002809 ATP-binding site [chemical binding]; other site 523791002810 Ultra-violet resistance protein B; Region: UvrB; pfam12344 523791002811 UvrB/uvrC motif; Region: UVR; pfam02151 523791002812 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 523791002813 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 523791002814 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 523791002815 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 523791002816 heterodimer interface [polypeptide binding]; other site 523791002817 homodimer interface [polypeptide binding]; other site 523791002818 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 523791002819 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 523791002820 active site 523791002821 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 523791002822 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 523791002823 SLBB domain; Region: SLBB; pfam10531 523791002824 SLBB domain; Region: SLBB; pfam10531 523791002825 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 523791002826 SLBB domain; Region: SLBB; pfam10531 523791002827 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 523791002828 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 523791002829 Chain length determinant protein; Region: Wzz; pfam02706 523791002830 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 523791002831 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 523791002832 Mg++ binding site [ion binding]; other site 523791002833 putative catalytic motif [active] 523791002834 substrate binding site [chemical binding]; other site 523791002835 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 523791002836 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 523791002837 active site 523791002838 homodimer interface [polypeptide binding]; other site 523791002839 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 523791002840 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 523791002841 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 523791002842 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 523791002843 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 523791002844 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 523791002845 putative trimer interface [polypeptide binding]; other site 523791002846 putative CoA binding site [chemical binding]; other site 523791002847 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 523791002848 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 523791002849 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 523791002850 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 523791002851 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 523791002852 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 523791002853 putative active site [active] 523791002854 putative metal binding site [ion binding]; other site 523791002855 O-Antigen ligase; Region: Wzy_C; pfam04932 523791002856 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 523791002857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523791002858 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 523791002859 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 523791002860 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 523791002861 trimer interface [polypeptide binding]; other site 523791002862 active site 523791002863 substrate binding site [chemical binding]; other site 523791002864 CoA binding site [chemical binding]; other site 523791002865 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932 523791002866 NodB motif; other site 523791002867 putative active site [active] 523791002868 putative catalytic site [active] 523791002869 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 523791002870 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 523791002871 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 523791002872 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 523791002873 Active Sites [active] 523791002874 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 523791002875 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 523791002876 CysD dimerization site [polypeptide binding]; other site 523791002877 G1 box; other site 523791002878 putative GEF interaction site [polypeptide binding]; other site 523791002879 GTP/Mg2+ binding site [chemical binding]; other site 523791002880 Switch I region; other site 523791002881 G2 box; other site 523791002882 G3 box; other site 523791002883 Switch II region; other site 523791002884 G4 box; other site 523791002885 G5 box; other site 523791002886 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 523791002887 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 523791002888 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523791002889 transmembrane helices; other site 523791002890 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523791002891 TrkA-C domain; Region: TrkA_C; pfam02080 523791002892 TrkA-C domain; Region: TrkA_C; pfam02080 523791002893 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523791002894 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 523791002895 Predicted kinase [General function prediction only]; Region: COG4639 523791002896 ligand-binding site [chemical binding]; other site 523791002897 endonuclease III; Provisional; Region: PRK10702 523791002898 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523791002899 minor groove reading motif; other site 523791002900 helix-hairpin-helix signature motif; other site 523791002901 substrate binding pocket [chemical binding]; other site 523791002902 active site 523791002903 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 523791002904 electron transport complex RsxE subunit; Provisional; Region: PRK12405 523791002905 FMN-binding domain; Region: FMN_bind; cl01081 523791002906 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 523791002907 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 523791002908 SLBB domain; Region: SLBB; pfam10531 523791002909 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 523791002910 ferredoxin; Provisional; Region: PRK08764 523791002911 Putative Fe-S cluster; Region: FeS; pfam04060 523791002912 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 523791002913 electron transport complex protein RsxA; Provisional; Region: PRK05151 523791002914 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 523791002915 response regulator; Provisional; Region: PRK09483 523791002916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791002917 active site 523791002918 phosphorylation site [posttranslational modification] 523791002919 intermolecular recognition site; other site 523791002920 dimerization interface [polypeptide binding]; other site 523791002921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523791002922 DNA binding residues [nucleotide binding] 523791002923 dimerization interface [polypeptide binding]; other site 523791002924 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 523791002925 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 523791002926 GIY-YIG motif/motif A; other site 523791002927 active site 523791002928 catalytic site [active] 523791002929 putative DNA binding site [nucleotide binding]; other site 523791002930 metal binding site [ion binding]; metal-binding site 523791002931 UvrB/uvrC motif; Region: UVR; pfam02151 523791002932 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 523791002933 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 523791002934 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 523791002935 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 523791002936 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 523791002937 protein binding site [polypeptide binding]; other site 523791002938 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 523791002939 putative catalytic site [active] 523791002940 putative phosphate binding site [ion binding]; other site 523791002941 active site 523791002942 metal binding site A [ion binding]; metal-binding site 523791002943 DNA binding site [nucleotide binding] 523791002944 putative AP binding site [nucleotide binding]; other site 523791002945 putative metal binding site B [ion binding]; other site 523791002946 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 523791002947 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 523791002948 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 523791002949 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 523791002950 substrate binding site [chemical binding]; other site 523791002951 ATP binding site [chemical binding]; other site 523791002952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523791002953 catalytic core [active] 523791002954 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523791002955 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523791002956 putative acyl-acceptor binding pocket; other site 523791002957 HemK family putative methylases; Region: hemK_fam; TIGR00536 523791002958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791002959 S-adenosylmethionine binding site [chemical binding]; other site 523791002960 Protein of unknown function, DUF462; Region: DUF462; pfam04315 523791002961 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 523791002962 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523791002963 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 523791002964 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 523791002965 TrkA-N domain; Region: TrkA_N; pfam02254 523791002966 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 523791002967 Pirin-related protein [General function prediction only]; Region: COG1741 523791002968 Pirin; Region: Pirin; pfam02678 523791002969 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 523791002970 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 523791002971 Uncharacterized conserved protein [Function unknown]; Region: COG4121 523791002972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523791002973 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 523791002974 homodecamer interface [polypeptide binding]; other site 523791002975 GTP cyclohydrolase I; Provisional; Region: PLN03044 523791002976 active site 523791002977 putative catalytic site residues [active] 523791002978 zinc binding site [ion binding]; other site 523791002979 GTP-CH-I/GFRP interaction surface; other site 523791002980 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 523791002981 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 523791002982 ligand binding site [chemical binding]; other site 523791002983 NAD binding site [chemical binding]; other site 523791002984 catalytic site [active] 523791002985 homodimer interface [polypeptide binding]; other site 523791002986 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523791002987 DNA-binding site [nucleotide binding]; DNA binding site 523791002988 RNA-binding motif; other site 523791002989 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523791002990 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523791002991 ATP binding site [chemical binding]; other site 523791002992 Mg++ binding site [ion binding]; other site 523791002993 motif III; other site 523791002994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791002995 nucleotide binding region [chemical binding]; other site 523791002996 ATP-binding site [chemical binding]; other site 523791002997 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 523791002998 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 523791002999 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 523791003000 active site 523791003001 dimer interface [polypeptide binding]; other site 523791003002 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 523791003003 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 523791003004 hydrophobic ligand binding site; other site 523791003005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523791003006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791003007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523791003008 dimerization interface [polypeptide binding]; other site 523791003009 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 523791003010 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 523791003011 substrate binding site [chemical binding]; other site 523791003012 ligand binding site [chemical binding]; other site 523791003013 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 523791003014 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 523791003015 substrate binding site [chemical binding]; other site 523791003016 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 523791003017 tartrate dehydrogenase; Region: TTC; TIGR02089 523791003018 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 523791003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791003020 Walker A/P-loop; other site 523791003021 ATP binding site [chemical binding]; other site 523791003022 Q-loop/lid; other site 523791003023 ABC transporter signature motif; other site 523791003024 Walker B; other site 523791003025 D-loop; other site 523791003026 H-loop/switch region; other site 523791003027 heme exporter protein CcmB; Region: ccmB; TIGR01190 523791003028 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 523791003029 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 523791003030 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 523791003031 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 523791003032 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 523791003033 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791003034 catalytic residues [active] 523791003035 central insert; other site 523791003036 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 523791003037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523791003038 binding surface 523791003039 TPR motif; other site 523791003040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003041 binding surface 523791003042 TPR motif; other site 523791003043 hypothetical protein; Provisional; Region: PRK05409 523791003044 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 523791003045 VacJ like lipoprotein; Region: VacJ; cl01073 523791003046 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 523791003047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003049 Amidohydrolase; Region: Amidohydro_4; pfam13147 523791003050 active site 523791003051 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 523791003052 TIGR01777 family protein; Region: yfcH 523791003053 putative NAD(P) binding site [chemical binding]; other site 523791003054 putative active site [active] 523791003055 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 523791003056 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 523791003057 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 523791003058 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 523791003059 putative active site [active] 523791003060 putative CoA binding site [chemical binding]; other site 523791003061 nudix motif; other site 523791003062 metal binding site [ion binding]; metal-binding site 523791003063 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 523791003064 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 523791003065 chorismate binding enzyme; Region: Chorismate_bind; cl10555 523791003066 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 523791003067 Fumarase C-terminus; Region: Fumerase_C; pfam05683 523791003068 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 523791003069 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 523791003070 tetramer interface [polypeptide binding]; other site 523791003071 active site 523791003072 Mg2+/Mn2+ binding site [ion binding]; other site 523791003073 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 523791003074 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 523791003075 dimer interface [polypeptide binding]; other site 523791003076 active site 523791003077 citrylCoA binding site [chemical binding]; other site 523791003078 oxalacetate/citrate binding site [chemical binding]; other site 523791003079 coenzyme A binding site [chemical binding]; other site 523791003080 catalytic triad [active] 523791003081 aconitate hydratase; Validated; Region: PRK09277 523791003082 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 523791003083 substrate binding site [chemical binding]; other site 523791003084 ligand binding site [chemical binding]; other site 523791003085 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 523791003086 substrate binding site [chemical binding]; other site 523791003087 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 523791003088 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 523791003089 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 523791003090 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 523791003091 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 523791003092 Multicopper oxidase; Region: Cu-oxidase; pfam00394 523791003093 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 523791003094 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 523791003095 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 523791003096 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 523791003097 2-methylcitrate dehydratase; Region: prpD; TIGR02330 523791003098 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 523791003099 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003100 active site 523791003101 hypothetical protein; Provisional; Region: PRK11019 523791003102 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 523791003103 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 523791003104 active site 523791003105 Uncharacterized conserved protein [Function unknown]; Region: COG5276 523791003106 Uncharacterized conserved protein [Function unknown]; Region: COG5276 523791003107 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 523791003108 Ca2+ binding site [ion binding]; other site 523791003109 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 523791003110 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 523791003111 C factor cell-cell signaling protein; Provisional; Region: PRK09009 523791003112 NADP binding site [chemical binding]; other site 523791003113 homodimer interface [polypeptide binding]; other site 523791003114 active site 523791003115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523791003116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791003117 Coenzyme A binding pocket [chemical binding]; other site 523791003118 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 523791003119 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 523791003120 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523791003121 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 523791003122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791003123 Walker A motif; other site 523791003124 ATP binding site [chemical binding]; other site 523791003125 Walker B motif; other site 523791003126 DNA polymerase III subunit delta'; Validated; Region: PRK08485 523791003127 arginine finger; other site 523791003128 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 523791003129 hypothetical protein; Validated; Region: PRK00153 523791003130 recombination protein RecR; Reviewed; Region: recR; PRK00076 523791003131 RecR protein; Region: RecR; pfam02132 523791003132 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 523791003133 putative active site [active] 523791003134 putative metal-binding site [ion binding]; other site 523791003135 tetramer interface [polypeptide binding]; other site 523791003136 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 523791003137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791003138 S-adenosylmethionine binding site [chemical binding]; other site 523791003139 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523791003140 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523791003141 Active site serine [active] 523791003142 heat shock protein 90; Provisional; Region: PRK05218 523791003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 523791003144 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 523791003145 active site 523791003146 substrate binding sites [chemical binding]; other site 523791003147 Predicted integral membrane protein [Function unknown]; Region: COG5652 523791003148 adenylate kinase; Reviewed; Region: adk; PRK00279 523791003149 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 523791003150 AMP-binding site [chemical binding]; other site 523791003151 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 523791003152 ferrochelatase; Reviewed; Region: hemH; PRK00035 523791003153 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 523791003154 C-terminal domain interface [polypeptide binding]; other site 523791003155 active site 523791003156 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 523791003157 active site 523791003158 N-terminal domain interface [polypeptide binding]; other site 523791003159 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 523791003160 DEAD/DEAH box helicase; Region: DEAD; pfam00270 523791003161 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 523791003162 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 523791003163 Glycoprotease family; Region: Peptidase_M22; pfam00814 523791003164 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 523791003165 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 523791003166 multidrug efflux protein; Reviewed; Region: PRK01766 523791003167 cation binding site [ion binding]; other site 523791003168 Cupin superfamily protein; Region: Cupin_4; pfam08007 523791003169 Cupin domain; Region: Cupin_2; cl17218 523791003170 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 523791003171 adenylosuccinate lyase; Provisional; Region: PRK09285 523791003172 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 523791003173 tetramer interface [polypeptide binding]; other site 523791003174 active site 523791003175 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 523791003176 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 523791003177 substrate binding site [chemical binding]; other site 523791003178 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 523791003179 substrate binding site [chemical binding]; other site 523791003180 ligand binding site [chemical binding]; other site 523791003181 MAPEG family; Region: MAPEG; cl09190 523791003182 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523791003183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523791003184 substrate binding pocket [chemical binding]; other site 523791003185 membrane-bound complex binding site; other site 523791003186 hinge residues; other site 523791003187 PAS domain; Region: PAS_9; pfam13426 523791003188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791003189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791003190 metal binding site [ion binding]; metal-binding site 523791003191 active site 523791003192 I-site; other site 523791003193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791003194 Peptidase S46; Region: Peptidase_S46; pfam10459 523791003195 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 523791003196 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 523791003197 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 523791003198 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 523791003199 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 523791003200 active site 523791003201 catalytic residues [active] 523791003202 metal binding site [ion binding]; metal-binding site 523791003203 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 523791003204 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523791003205 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523791003206 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 523791003207 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523791003208 carboxyltransferase (CT) interaction site; other site 523791003209 biotinylation site [posttranslational modification]; other site 523791003210 enoyl-CoA hydratase; Provisional; Region: PRK05995 523791003211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523791003212 substrate binding site [chemical binding]; other site 523791003213 oxyanion hole (OAH) forming residues; other site 523791003214 trimer interface [polypeptide binding]; other site 523791003215 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 523791003216 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 523791003217 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 523791003218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523791003219 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 523791003220 FAD binding site [chemical binding]; other site 523791003221 homotetramer interface [polypeptide binding]; other site 523791003222 substrate binding pocket [chemical binding]; other site 523791003223 catalytic base [active] 523791003224 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 523791003225 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523791003226 dimer interface [polypeptide binding]; other site 523791003227 active site 523791003228 isovaleryl-CoA dehydrogenase; Region: PLN02519 523791003229 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 523791003230 substrate binding site [chemical binding]; other site 523791003231 FAD binding site [chemical binding]; other site 523791003232 catalytic base [active] 523791003233 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 523791003234 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 523791003235 DNA binding residues [nucleotide binding] 523791003236 putative dimer interface [polypeptide binding]; other site 523791003237 Ribosome modulation factor; Region: RMF; cl01207 523791003238 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523791003239 Sel1-like repeats; Region: SEL1; smart00671 523791003240 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791003241 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523791003242 Sel1-like repeats; Region: SEL1; smart00671 523791003243 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 523791003244 MG2 domain; Region: A2M_N; pfam01835 523791003245 Alpha-2-macroglobulin family; Region: A2M; pfam00207 523791003246 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 523791003247 surface patch; other site 523791003248 thioester region; other site 523791003249 specificity defining residues; other site 523791003250 penicillin-binding protein 1C; Provisional; Region: PRK11240 523791003251 Transglycosylase; Region: Transgly; pfam00912 523791003252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 523791003253 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 523791003254 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 523791003255 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 523791003256 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 523791003257 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 523791003258 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 523791003259 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 523791003260 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 523791003261 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 523791003262 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 523791003263 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 523791003264 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 523791003265 Protein export membrane protein; Region: SecD_SecF; pfam02355 523791003266 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523791003267 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523791003268 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 523791003269 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 523791003270 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523791003271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791003272 FeS/SAM binding site; other site 523791003273 TRAM domain; Region: TRAM; cl01282 523791003274 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 523791003275 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 523791003276 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 523791003277 Type II transport protein GspH; Region: GspH; pfam12019 523791003278 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 523791003279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791003280 active site 523791003281 phosphorylation site [posttranslational modification] 523791003282 intermolecular recognition site; other site 523791003283 dimerization interface [polypeptide binding]; other site 523791003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791003285 Walker A motif; other site 523791003286 ATP binding site [chemical binding]; other site 523791003287 Walker B motif; other site 523791003288 arginine finger; other site 523791003289 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 523791003290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523791003291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791003292 dimer interface [polypeptide binding]; other site 523791003293 phosphorylation site [posttranslational modification] 523791003294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791003295 ATP binding site [chemical binding]; other site 523791003296 Mg2+ binding site [ion binding]; other site 523791003297 G-X-G motif; other site 523791003298 NAD synthetase; Provisional; Region: PRK13981 523791003299 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 523791003300 multimer interface [polypeptide binding]; other site 523791003301 active site 523791003302 catalytic triad [active] 523791003303 protein interface 1 [polypeptide binding]; other site 523791003304 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 523791003305 homodimer interface [polypeptide binding]; other site 523791003306 NAD binding pocket [chemical binding]; other site 523791003307 ATP binding pocket [chemical binding]; other site 523791003308 Mg binding site [ion binding]; other site 523791003309 active-site loop [active] 523791003310 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 523791003311 Nitrogen regulatory protein P-II; Region: P-II; smart00938 523791003312 Outer membrane lipoprotein; Region: YfiO; pfam13525 523791003313 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 523791003314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791003315 RNA binding surface [nucleotide binding]; other site 523791003316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523791003317 active site 523791003318 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 523791003319 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 523791003320 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523791003321 putative acyl-acceptor binding pocket; other site 523791003322 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 523791003323 Clp amino terminal domain; Region: Clp_N; pfam02861 523791003324 Clp amino terminal domain; Region: Clp_N; pfam02861 523791003325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791003326 Walker A motif; other site 523791003327 ATP binding site [chemical binding]; other site 523791003328 Walker B motif; other site 523791003329 arginine finger; other site 523791003330 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 523791003331 primary dimer interface [polypeptide binding]; other site 523791003332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791003333 Walker A motif; other site 523791003334 ATP binding site [chemical binding]; other site 523791003335 Walker B motif; other site 523791003336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523791003337 NnrS protein; Region: NnrS; pfam05940 523791003338 transcription termination factor Rho; Provisional; Region: PRK12678 523791003339 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 523791003340 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 523791003341 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 523791003342 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 523791003343 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 523791003344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791003345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791003346 DNA binding residues [nucleotide binding] 523791003347 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 523791003348 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523791003349 putative lysogenization regulator; Reviewed; Region: PRK00218 523791003350 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 523791003351 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 523791003352 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 523791003353 nudix motif; other site 523791003354 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 523791003355 pseudouridine synthase; Region: TIGR00093 523791003356 active site 523791003357 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 523791003358 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 523791003359 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 523791003360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791003361 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791003362 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791003363 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 523791003364 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 523791003365 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 523791003366 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 523791003367 active site 523791003368 DNA binding site [nucleotide binding] 523791003369 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 523791003370 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 523791003371 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 523791003372 Catalytic site [active] 523791003373 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 523791003374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523791003375 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 523791003376 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 523791003377 tetramer interface [polypeptide binding]; other site 523791003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791003379 catalytic residue [active] 523791003380 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 523791003381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791003382 Fatty acid desaturase; Region: FA_desaturase; pfam00487 523791003383 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 523791003384 Di-iron ligands [ion binding]; other site 523791003385 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 523791003386 thioredoxin reductase; Provisional; Region: PRK10262 523791003387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791003388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523791003389 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 523791003390 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523791003391 DNA-binding site [nucleotide binding]; DNA binding site 523791003392 RNA-binding motif; other site 523791003393 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 523791003394 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791003395 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 523791003396 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 523791003397 hexamer interface [polypeptide binding]; other site 523791003398 ligand binding site [chemical binding]; other site 523791003399 putative active site [active] 523791003400 NAD(P) binding site [chemical binding]; other site 523791003401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523791003402 putative DNA binding site [nucleotide binding]; other site 523791003403 dimerization interface [polypeptide binding]; other site 523791003404 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 523791003405 putative Zn2+ binding site [ion binding]; other site 523791003406 AsnC family; Region: AsnC_trans_reg; pfam01037 523791003407 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 523791003408 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523791003409 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 523791003410 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 523791003411 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 523791003412 recombination factor protein RarA; Reviewed; Region: PRK13342 523791003413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791003414 Walker A motif; other site 523791003415 ATP binding site [chemical binding]; other site 523791003416 Walker B motif; other site 523791003417 arginine finger; other site 523791003418 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 523791003419 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 523791003420 seryl-tRNA synthetase; Provisional; Region: PRK05431 523791003421 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 523791003422 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 523791003423 dimer interface [polypeptide binding]; other site 523791003424 active site 523791003425 motif 1; other site 523791003426 motif 2; other site 523791003427 motif 3; other site 523791003428 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523791003429 active site residue [active] 523791003430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 523791003431 active site 523791003432 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 523791003433 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 523791003434 putative active site; other site 523791003435 catalytic triad [active] 523791003436 putative dimer interface [polypeptide binding]; other site 523791003437 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 523791003438 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 523791003439 arginine decarboxylase; Provisional; Region: PRK05354 523791003440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 523791003441 dimer interface [polypeptide binding]; other site 523791003442 active site 523791003443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523791003444 catalytic residues [active] 523791003445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 523791003446 spermidine synthase; Provisional; Region: PRK00811 523791003447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791003448 S-adenosylmethionine binding site [chemical binding]; other site 523791003449 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 523791003450 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 523791003451 EamA-like transporter family; Region: EamA; pfam00892 523791003452 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 523791003453 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 523791003454 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 523791003455 NAD binding site [chemical binding]; other site 523791003456 Phe binding site; other site 523791003457 aldehyde dehydrogenase family 7 member; Region: PLN02315 523791003458 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 523791003459 tetrameric interface [polypeptide binding]; other site 523791003460 NAD binding site [chemical binding]; other site 523791003461 catalytic residues [active] 523791003462 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 523791003463 EF-hand domain pair; Region: EF_hand_5; pfam13499 523791003464 Ca2+ binding site [ion binding]; other site 523791003465 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 523791003466 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 523791003467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791003468 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 523791003469 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 523791003470 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 523791003471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523791003472 ATP binding site [chemical binding]; other site 523791003473 putative Mg++ binding site [ion binding]; other site 523791003474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791003475 nucleotide binding region [chemical binding]; other site 523791003476 ATP-binding site [chemical binding]; other site 523791003477 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 523791003478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791003479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791003480 metal binding site [ion binding]; metal-binding site 523791003481 active site 523791003482 I-site; other site 523791003483 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 523791003484 TrkA-N domain; Region: TrkA_N; pfam02254 523791003485 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 523791003486 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 523791003487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791003488 Zn2+ binding site [ion binding]; other site 523791003489 Mg2+ binding site [ion binding]; other site 523791003490 Ion transport protein; Region: Ion_trans; pfam00520 523791003491 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 523791003492 bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme; Region: LKR_SDH_like; cd12189 523791003493 active site 523791003494 ligand binding site [chemical binding]; other site 523791003495 putative NAD(P) binding site [chemical binding]; other site 523791003496 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 523791003497 active site 523791003498 homodimer interface [polypeptide binding]; other site 523791003499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523791003500 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791003501 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791003502 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 523791003503 thiamine kinase; Region: ycfN_thiK; TIGR02721 523791003504 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 523791003505 substrate binding site [chemical binding]; other site 523791003506 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 523791003507 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523791003508 metal binding site [ion binding]; metal-binding site 523791003509 putative dimer interface [polypeptide binding]; other site 523791003510 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 523791003511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523791003512 active site 523791003513 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 523791003514 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 523791003515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523791003516 ATP binding site [chemical binding]; other site 523791003517 putative Mg++ binding site [ion binding]; other site 523791003518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791003519 nucleotide binding region [chemical binding]; other site 523791003520 ATP-binding site [chemical binding]; other site 523791003521 Helicase associated domain (HA2); Region: HA2; pfam04408 523791003522 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 523791003523 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 523791003524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 523791003525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 523791003526 active site 523791003527 phosphorylation site [posttranslational modification] 523791003528 intermolecular recognition site; other site 523791003529 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 523791003530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791003531 active site 523791003532 phosphorylation site [posttranslational modification] 523791003533 intermolecular recognition site; other site 523791003534 dimerization interface [polypeptide binding]; other site 523791003535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791003536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791003537 metal binding site [ion binding]; metal-binding site 523791003538 active site 523791003539 I-site; other site 523791003540 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 523791003541 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 523791003542 putative sulfate transport protein CysZ; Validated; Region: PRK04949 523791003543 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523791003544 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523791003545 Walker A/P-loop; other site 523791003546 ATP binding site [chemical binding]; other site 523791003547 Q-loop/lid; other site 523791003548 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 523791003549 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523791003550 ABC transporter signature motif; other site 523791003551 Walker B; other site 523791003552 D-loop; other site 523791003553 H-loop/switch region; other site 523791003554 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 523791003555 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 523791003556 FtsZ protein binding site [polypeptide binding]; other site 523791003557 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 523791003558 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 523791003559 nucleotide binding pocket [chemical binding]; other site 523791003560 K-X-D-G motif; other site 523791003561 catalytic site [active] 523791003562 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 523791003563 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 523791003564 Helix-hairpin-helix motif; Region: HHH; pfam00633 523791003565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523791003566 catalytic core [active] 523791003567 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 523791003568 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 523791003569 homodimer interface [polypeptide binding]; other site 523791003570 oligonucleotide binding site [chemical binding]; other site 523791003571 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 523791003572 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791003573 RNA binding surface [nucleotide binding]; other site 523791003574 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523791003575 active site 523791003576 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 523791003577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791003578 active site 523791003579 motif I; other site 523791003580 motif II; other site 523791003581 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 523791003582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003583 TPR motif; other site 523791003584 binding surface 523791003585 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 523791003586 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 523791003587 putative active site [active] 523791003588 putative metal binding site [ion binding]; other site 523791003589 N-glycosyltransferase; Provisional; Region: PRK11204 523791003590 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 523791003591 DXD motif; other site 523791003592 PgaD-like protein; Region: PgaD; pfam13994 523791003593 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 523791003594 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 523791003595 catalytic triad [active] 523791003596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791003597 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523791003598 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 523791003599 putative ADP-ribose binding site [chemical binding]; other site 523791003600 putative active site [active] 523791003601 Fructosamine kinase; Region: Fructosamin_kin; cl17579 523791003602 Phosphotransferase enzyme family; Region: APH; pfam01636 523791003603 Maf-like protein; Region: Maf; pfam02545 523791003604 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 523791003605 active site 523791003606 dimer interface [polypeptide binding]; other site 523791003607 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 523791003608 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 523791003609 putative phosphate acyltransferase; Provisional; Region: PRK05331 523791003610 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 523791003611 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 523791003612 dimer interface [polypeptide binding]; other site 523791003613 active site 523791003614 CoA binding pocket [chemical binding]; other site 523791003615 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 523791003616 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 523791003617 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 523791003618 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 523791003619 NAD(P) binding site [chemical binding]; other site 523791003620 homotetramer interface [polypeptide binding]; other site 523791003621 homodimer interface [polypeptide binding]; other site 523791003622 active site 523791003623 acyl carrier protein; Provisional; Region: acpP; PRK00982 523791003624 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 523791003625 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523791003626 dimer interface [polypeptide binding]; other site 523791003627 active site 523791003628 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 523791003629 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 523791003630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791003631 catalytic residue [active] 523791003632 YceG-like family; Region: YceG; pfam02618 523791003633 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 523791003634 dimerization interface [polypeptide binding]; other site 523791003635 thymidylate kinase; Validated; Region: tmk; PRK00698 523791003636 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 523791003637 TMP-binding site; other site 523791003638 ATP-binding site [chemical binding]; other site 523791003639 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 523791003640 PilZ domain; Region: PilZ; cl01260 523791003641 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 523791003642 active site 523791003643 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791003644 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523791003645 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791003646 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791003647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523791003648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791003649 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791003650 active site 523791003651 catalytic residues [active] 523791003652 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791003653 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791003654 active site 523791003655 catalytic residues [active] 523791003656 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523791003657 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 523791003658 phosphopeptide binding site; other site 523791003659 GAF domain; Region: GAF; pfam01590 523791003660 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523791003661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523791003662 active site 523791003663 ATP binding site [chemical binding]; other site 523791003664 substrate binding site [chemical binding]; other site 523791003665 activation loop (A-loop); other site 523791003666 TPR repeat; Region: TPR_11; pfam13414 523791003667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003668 binding surface 523791003669 TPR motif; other site 523791003670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003671 TPR motif; other site 523791003672 TPR repeat; Region: TPR_11; pfam13414 523791003673 binding surface 523791003674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003675 binding surface 523791003676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791003677 TPR motif; other site 523791003678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791003679 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791003680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791003681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791003682 binding surface 523791003683 TPR motif; other site 523791003684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 523791003685 Histidine kinase; Region: HisKA_3; pfam07730 523791003686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791003687 ATP binding site [chemical binding]; other site 523791003688 Mg2+ binding site [ion binding]; other site 523791003689 G-X-G motif; other site 523791003690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 523791003691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791003692 active site 523791003693 phosphorylation site [posttranslational modification] 523791003694 intermolecular recognition site; other site 523791003695 dimerization interface [polypeptide binding]; other site 523791003696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523791003697 DNA binding residues [nucleotide binding] 523791003698 dimerization interface [polypeptide binding]; other site 523791003699 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791003700 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523791003701 active site 523791003702 catalytic residues [active] 523791003703 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 523791003704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523791003705 FAD binding site [chemical binding]; other site 523791003706 substrate binding pocket [chemical binding]; other site 523791003707 catalytic base [active] 523791003708 carboxy-terminal protease; Provisional; Region: PRK11186 523791003709 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 523791003710 protein binding site [polypeptide binding]; other site 523791003711 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 523791003712 Catalytic dyad [active] 523791003713 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 523791003714 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523791003715 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 523791003716 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 523791003717 Cl binding site [ion binding]; other site 523791003718 oligomer interface [polypeptide binding]; other site 523791003719 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523791003720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791003721 catalytic residue [active] 523791003722 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 523791003723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791003724 FeS/SAM binding site; other site 523791003725 DGC domain; Region: DGC; pfam08859 523791003726 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 523791003727 ATP cone domain; Region: ATP-cone; pfam03477 523791003728 Class III ribonucleotide reductase; Region: RNR_III; cd01675 523791003729 effector binding site; other site 523791003730 active site 523791003731 Zn binding site [ion binding]; other site 523791003732 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 523791003733 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 523791003734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791003735 FeS/SAM binding site; other site 523791003736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 523791003737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 523791003738 ligand binding site [chemical binding]; other site 523791003739 flexible hinge region; other site 523791003740 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 523791003741 putative switch regulator; other site 523791003742 non-specific DNA interactions [nucleotide binding]; other site 523791003743 DNA binding site [nucleotide binding] 523791003744 sequence specific DNA binding site [nucleotide binding]; other site 523791003745 putative cAMP binding site [chemical binding]; other site 523791003746 putative protease; Provisional; Region: PRK15452 523791003747 Peptidase family U32; Region: Peptidase_U32; pfam01136 523791003748 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 523791003749 cofactor binding site; other site 523791003750 metal binding site [ion binding]; metal-binding site 523791003751 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 523791003752 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791003753 Zn binding site [ion binding]; other site 523791003754 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 523791003755 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 523791003756 dimer interface [polypeptide binding]; other site 523791003757 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 523791003758 active site 523791003759 Fe binding site [ion binding]; other site 523791003760 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 523791003761 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 523791003762 ATP binding site [chemical binding]; other site 523791003763 substrate interface [chemical binding]; other site 523791003764 MgtC family; Region: MgtC; pfam02308 523791003765 Pirin-related protein [General function prediction only]; Region: COG1741 523791003766 Pirin; Region: Pirin; pfam02678 523791003767 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 523791003768 short chain dehydrogenase; Provisional; Region: PRK06172 523791003769 classical (c) SDRs; Region: SDR_c; cd05233 523791003770 NAD(P) binding site [chemical binding]; other site 523791003771 active site 523791003772 Kelch motif; Region: Kelch_1; pfam01344 523791003773 Kelch motif; Region: Kelch_6; pfam13964 523791003774 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791003775 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 523791003776 active site 523791003777 Amino acid permease; Region: AA_permease_2; pfam13520 523791003778 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 523791003779 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 523791003780 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 523791003781 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 523791003782 Methyltransferase domain; Region: Methyltransf_25; pfam13649 523791003783 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 523791003784 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523791003785 Predicted membrane protein [Function unknown]; Region: COG1238 523791003786 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791003787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003789 active site 523791003790 Predicted membrane protein [Function unknown]; Region: COG2259 523791003791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523791003792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791003793 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 523791003794 putative effector binding pocket; other site 523791003795 dimerization interface [polypeptide binding]; other site 523791003796 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791003797 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791003798 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 523791003799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791003800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791003801 DNA binding residues [nucleotide binding] 523791003802 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 523791003803 oxaloacetate decarboxylase; Provisional; Region: PRK14040 523791003804 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 523791003805 active site 523791003806 catalytic residues [active] 523791003807 metal binding site [ion binding]; metal-binding site 523791003808 homodimer binding site [polypeptide binding]; other site 523791003809 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523791003810 carboxyltransferase (CT) interaction site; other site 523791003811 biotinylation site [posttranslational modification]; other site 523791003812 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 523791003813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003815 Amidohydrolase; Region: Amidohydro_4; pfam13147 523791003816 active site 523791003817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791003818 Helix-turn-helix domain; Region: HTH_18; pfam12833 523791003819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523791003820 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 523791003821 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 523791003822 AAA ATPase domain; Region: AAA_16; pfam13191 523791003823 AAA domain; Region: AAA_22; pfam13401 523791003824 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 523791003825 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 523791003826 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 523791003827 DNA binding site [nucleotide binding] 523791003828 dimer interface [polypeptide binding]; other site 523791003829 active site 523791003830 Int/Topo IB signature motif; other site 523791003831 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 523791003832 Outer membrane efflux protein; Region: OEP; pfam02321 523791003833 Outer membrane efflux protein; Region: OEP; pfam02321 523791003834 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 523791003835 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791003836 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 523791003837 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 523791003838 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 523791003839 DNA binding residues [nucleotide binding] 523791003840 dimer interface [polypeptide binding]; other site 523791003841 putative metal binding site [ion binding]; other site 523791003842 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523791003843 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523791003844 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 523791003845 putative mercuric reductase; Provisional; Region: PRK13748 523791003846 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791003847 metal-binding site [ion binding] 523791003848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523791003849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791003850 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523791003851 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791003852 metal-binding site [ion binding] 523791003853 MerT mercuric transport protein; Region: MerT; cl03578 523791003854 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 523791003855 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 523791003856 DNA binding residues [nucleotide binding] 523791003857 dimer interface [polypeptide binding]; other site 523791003858 mercury binding site [ion binding]; other site 523791003859 Penicillinase repressor; Region: Pencillinase_R; cl17580 523791003860 Peptidase family M48; Region: Peptidase_M48; cl12018 523791003861 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 523791003862 Outer membrane efflux protein; Region: OEP; pfam02321 523791003863 Outer membrane efflux protein; Region: OEP; pfam02321 523791003864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523791003865 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791003866 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 523791003867 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 523791003868 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 523791003869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791003870 SnoaL-like domain; Region: SnoaL_3; pfam13474 523791003871 Cytochrome c; Region: Cytochrom_C; pfam00034 523791003872 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 523791003873 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 523791003874 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 523791003875 [2Fe-2S] cluster binding site [ion binding]; other site 523791003876 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 523791003877 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 523791003878 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 523791003879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523791003880 dimerization interface [polypeptide binding]; other site 523791003881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791003882 dimer interface [polypeptide binding]; other site 523791003883 phosphorylation site [posttranslational modification] 523791003884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791003885 ATP binding site [chemical binding]; other site 523791003886 Mg2+ binding site [ion binding]; other site 523791003887 G-X-G motif; other site 523791003888 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 523791003889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791003890 active site 523791003891 phosphorylation site [posttranslational modification] 523791003892 intermolecular recognition site; other site 523791003893 dimerization interface [polypeptide binding]; other site 523791003894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791003895 DNA binding site [nucleotide binding] 523791003896 O-Antigen ligase; Region: Wzy_C; cl04850 523791003897 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 523791003898 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 523791003899 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 523791003900 Multicopper oxidase; Region: Cu-oxidase; pfam00394 523791003901 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 523791003902 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 523791003903 Amino acid permease; Region: AA_permease_2; pfam13520 523791003904 Protein of unknown function, DUF; Region: DUF411; cl01142 523791003905 Outer membrane efflux protein; Region: OEP; pfam02321 523791003906 Outer membrane efflux protein; Region: OEP; pfam02321 523791003907 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 523791003908 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791003909 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 523791003910 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 523791003911 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 523791003912 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523791003913 DNA binding residues [nucleotide binding] 523791003914 dimer interface [polypeptide binding]; other site 523791003915 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523791003916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791003917 metal-binding site [ion binding] 523791003918 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523791003919 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523791003920 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 523791003921 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 523791003922 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 523791003923 thymidine phosphorylase; Provisional; Region: PRK04350 523791003924 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523791003925 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523791003926 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 523791003927 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 523791003928 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523791003929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791003930 active site 523791003931 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 523791003932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523791003933 Beta-Casp domain; Region: Beta-Casp; smart01027 523791003934 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 523791003935 Acetokinase family; Region: Acetate_kinase; cl17229 523791003936 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 523791003937 XFP N-terminal domain; Region: XFP_N; pfam09364 523791003938 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 523791003939 PLD-like domain; Region: PLDc_2; pfam13091 523791003940 putative active site [active] 523791003941 catalytic site [active] 523791003942 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 523791003943 PLD-like domain; Region: PLDc_2; pfam13091 523791003944 putative active site [active] 523791003945 catalytic site [active] 523791003946 EamA-like transporter family; Region: EamA; pfam00892 523791003947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 523791003948 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 523791003949 MerT mercuric transport protein; Region: MerT; cl03578 523791003950 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791003951 metal-binding site [ion binding] 523791003952 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 523791003953 Initiator Replication protein; Region: Rep_3; pfam01051 523791003954 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 523791003955 trimer interface [polypeptide binding]; other site 523791003956 dimer interface [polypeptide binding]; other site 523791003957 putative active site [active] 523791003958 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 523791003959 MoaE interaction surface [polypeptide binding]; other site 523791003960 MoeB interaction surface [polypeptide binding]; other site 523791003961 thiocarboxylated glycine; other site 523791003962 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 523791003963 MoaE homodimer interface [polypeptide binding]; other site 523791003964 MoaD interaction [polypeptide binding]; other site 523791003965 active site residues [active] 523791003966 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 523791003967 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 523791003968 GTP binding site; other site 523791003969 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 523791003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791003971 Walker A/P-loop; other site 523791003972 ATP binding site [chemical binding]; other site 523791003973 Q-loop/lid; other site 523791003974 ABC transporter signature motif; other site 523791003975 Walker B; other site 523791003976 D-loop; other site 523791003977 H-loop/switch region; other site 523791003978 TOBE domain; Region: TOBE; cl01440 523791003979 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 523791003980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791003981 dimer interface [polypeptide binding]; other site 523791003982 conserved gate region; other site 523791003983 putative PBP binding loops; other site 523791003984 ABC-ATPase subunit interface; other site 523791003985 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 523791003986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 523791003987 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 523791003988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791003989 FeS/SAM binding site; other site 523791003990 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 523791003991 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 523791003992 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 523791003993 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 523791003994 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 523791003995 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 523791003996 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 523791003997 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 523791003998 [4Fe-4S] binding site [ion binding]; other site 523791003999 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 523791004000 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 523791004001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 523791004002 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 523791004003 molybdopterin cofactor binding site; other site 523791004004 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 523791004005 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 523791004006 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 523791004007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791004008 putative substrate translocation pore; other site 523791004009 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 523791004010 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 523791004011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523791004012 dimerization interface [polypeptide binding]; other site 523791004013 Histidine kinase; Region: HisKA_3; pfam07730 523791004014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791004015 ATP binding site [chemical binding]; other site 523791004016 Mg2+ binding site [ion binding]; other site 523791004017 G-X-G motif; other site 523791004018 transcriptional regulator NarL; Provisional; Region: PRK10651 523791004019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791004020 active site 523791004021 phosphorylation site [posttranslational modification] 523791004022 intermolecular recognition site; other site 523791004023 dimerization interface [polypeptide binding]; other site 523791004024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 523791004025 DNA binding residues [nucleotide binding] 523791004026 dimerization interface [polypeptide binding]; other site 523791004027 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 523791004028 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 523791004029 dimer interface [polypeptide binding]; other site 523791004030 putative functional site; other site 523791004031 putative MPT binding site; other site 523791004032 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 523791004033 MPT binding site; other site 523791004034 trimer interface [polypeptide binding]; other site 523791004035 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 523791004036 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 523791004037 ATP binding site [chemical binding]; other site 523791004038 substrate interface [chemical binding]; other site 523791004039 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 523791004040 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 523791004041 BCCT family transporter; Region: BCCT; pfam02028 523791004042 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 523791004043 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523791004044 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523791004045 metal-binding site [ion binding] 523791004046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523791004047 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523791004048 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 523791004049 DNA binding residues [nucleotide binding] 523791004050 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 523791004051 dimer interface [polypeptide binding]; other site 523791004052 mercury binding site [ion binding]; other site 523791004053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523791004054 dimerization interface [polypeptide binding]; other site 523791004055 putative DNA binding site [nucleotide binding]; other site 523791004056 putative Zn2+ binding site [ion binding]; other site 523791004057 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 523791004058 Low molecular weight phosphatase family; Region: LMWPc; cd00115 523791004059 active site 523791004060 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 523791004061 Sodium Bile acid symporter family; Region: SBF; cl17470 523791004062 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 523791004063 putative catalytic site [active] 523791004064 putative metal binding site [ion binding]; other site 523791004065 putative phosphate binding site [ion binding]; other site 523791004066 thymidine phosphorylase; Provisional; Region: PRK04350 523791004067 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523791004068 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523791004069 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 523791004070 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 523791004071 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523791004072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791004073 active site 523791004074 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 523791004075 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523791004076 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523791004077 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 523791004078 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523791004079 Beta-Casp domain; Region: Beta-Casp; smart01027 523791004080 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 523791004081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791004082 S-adenosylmethionine binding site [chemical binding]; other site 523791004083 succinic semialdehyde dehydrogenase; Region: PLN02278 523791004084 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 523791004085 tetramerization interface [polypeptide binding]; other site 523791004086 NAD(P) binding site [chemical binding]; other site 523791004087 catalytic residues [active] 523791004088 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 523791004089 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 523791004090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523791004091 active site 523791004092 HIGH motif; other site 523791004093 nucleotide binding site [chemical binding]; other site 523791004094 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 523791004095 KMSK motif region; other site 523791004096 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 523791004097 tRNA binding surface [nucleotide binding]; other site 523791004098 anticodon binding site; other site 523791004099 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 523791004100 Low molecular weight phosphatase family; Region: LMWPc; cd00115 523791004101 active site 523791004102 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 523791004103 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 523791004104 Ligand binding site; other site 523791004105 oligomer interface; other site 523791004106 Uncharacterized conserved protein [Function unknown]; Region: COG2835 523791004107 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 523791004108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 523791004109 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 523791004110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523791004111 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 523791004112 Walker A/P-loop; other site 523791004113 ATP binding site [chemical binding]; other site 523791004114 Q-loop/lid; other site 523791004115 ABC transporter signature motif; other site 523791004116 Walker B; other site 523791004117 D-loop; other site 523791004118 H-loop/switch region; other site 523791004119 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523791004120 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523791004121 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 523791004122 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 523791004123 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 523791004124 Competence protein; Region: Competence; pfam03772 523791004125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523791004126 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 523791004127 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 523791004128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523791004129 Walker A/P-loop; other site 523791004130 ATP binding site [chemical binding]; other site 523791004131 Q-loop/lid; other site 523791004132 ABC transporter signature motif; other site 523791004133 Walker B; other site 523791004134 D-loop; other site 523791004135 H-loop/switch region; other site 523791004136 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 523791004137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523791004138 FtsX-like permease family; Region: FtsX; pfam02687 523791004139 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 523791004140 beta-hexosaminidase; Provisional; Region: PRK05337 523791004141 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 523791004142 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 523791004143 active site 523791004144 Zn binding site [ion binding]; other site 523791004145 MASE1; Region: MASE1; cl17823 523791004146 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791004147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791004148 metal binding site [ion binding]; metal-binding site 523791004149 active site 523791004150 I-site; other site 523791004151 Haemolysin-III related; Region: HlyIII; cl03831 523791004152 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 523791004153 PAS domain; Region: PAS_9; pfam13426 523791004154 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791004155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791004156 metal binding site [ion binding]; metal-binding site 523791004157 active site 523791004158 I-site; other site 523791004159 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791004160 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 523791004161 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 523791004162 active site 523791004163 FMN binding site [chemical binding]; other site 523791004164 2,4-decadienoyl-CoA binding site; other site 523791004165 catalytic residue [active] 523791004166 4Fe-4S cluster binding site [ion binding]; other site 523791004167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 523791004168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523791004169 protease 4; Provisional; Region: PRK10949 523791004170 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 523791004171 tandem repeat interface [polypeptide binding]; other site 523791004172 oligomer interface [polypeptide binding]; other site 523791004173 active site residues [active] 523791004174 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 523791004175 tandem repeat interface [polypeptide binding]; other site 523791004176 oligomer interface [polypeptide binding]; other site 523791004177 active site residues [active] 523791004178 hypothetical protein; Provisional; Region: PRK05170 523791004179 YcgL domain; Region: YcgL; pfam05166 523791004180 ribonuclease D; Region: rnd; TIGR01388 523791004181 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 523791004182 catalytic site [active] 523791004183 putative active site [active] 523791004184 putative substrate binding site [chemical binding]; other site 523791004185 HRDC domain; Region: HRDC; pfam00570 523791004186 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 523791004187 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 523791004188 acyl-activating enzyme (AAE) consensus motif; other site 523791004189 putative AMP binding site [chemical binding]; other site 523791004190 putative active site [active] 523791004191 putative CoA binding site [chemical binding]; other site 523791004192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 523791004193 Serine hydrolase (FSH1); Region: FSH1; pfam03959 523791004194 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 523791004195 catalytic site [active] 523791004196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523791004197 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 523791004198 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 523791004199 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 523791004200 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791004201 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791004202 active site 523791004203 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791004204 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 523791004205 active site 523791004206 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 523791004207 Na2 binding site [ion binding]; other site 523791004208 putative substrate binding site 1 [chemical binding]; other site 523791004209 Na binding site 1 [ion binding]; other site 523791004210 putative substrate binding site 2 [chemical binding]; other site 523791004211 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 523791004212 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 523791004213 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 523791004214 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523791004215 active site 523791004216 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 523791004217 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 523791004218 amino acid carrier protein; Region: agcS; TIGR00835 523791004219 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 523791004220 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 523791004221 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 523791004222 active site 523791004223 DNA polymerase IV; Validated; Region: PRK02406 523791004224 DNA binding site [nucleotide binding] 523791004225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791004226 dimer interface [polypeptide binding]; other site 523791004227 phosphorylation site [posttranslational modification] 523791004228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791004229 ATP binding site [chemical binding]; other site 523791004230 Mg2+ binding site [ion binding]; other site 523791004231 G-X-G motif; other site 523791004232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523791004233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791004234 active site 523791004235 phosphorylation site [posttranslational modification] 523791004236 intermolecular recognition site; other site 523791004237 dimerization interface [polypeptide binding]; other site 523791004238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791004239 DNA binding site [nucleotide binding] 523791004240 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523791004241 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 523791004242 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 523791004243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523791004244 acyl-activating enzyme (AAE) consensus motif; other site 523791004245 AMP binding site [chemical binding]; other site 523791004246 active site 523791004247 CoA binding site [chemical binding]; other site 523791004248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791004249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 523791004250 Coenzyme A binding pocket [chemical binding]; other site 523791004251 phosphoenolpyruvate synthase; Validated; Region: PRK06464 523791004252 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 523791004253 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 523791004254 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 523791004255 PEP synthetase regulatory protein; Provisional; Region: PRK05339 523791004256 succinylglutamate desuccinylase; Provisional; Region: PRK05324 523791004257 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 523791004258 active site 523791004259 Zn binding site [ion binding]; other site 523791004260 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523791004261 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791004262 RmuC family; Region: RmuC; pfam02646 523791004263 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 523791004264 active site 523791004265 catalytic residues [active] 523791004266 CHASE domain; Region: CHASE; cl01369 523791004267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791004268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791004269 metal binding site [ion binding]; metal-binding site 523791004270 active site 523791004271 I-site; other site 523791004272 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523791004273 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791004274 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523791004275 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523791004276 FtsX-like permease family; Region: FtsX; pfam02687 523791004277 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 523791004278 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523791004279 FtsX-like permease family; Region: FtsX; pfam02687 523791004280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523791004281 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523791004282 Walker A/P-loop; other site 523791004283 ATP binding site [chemical binding]; other site 523791004284 Q-loop/lid; other site 523791004285 ABC transporter signature motif; other site 523791004286 Walker B; other site 523791004287 D-loop; other site 523791004288 H-loop/switch region; other site 523791004289 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 523791004290 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 523791004291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791004292 RNA binding surface [nucleotide binding]; other site 523791004293 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 523791004294 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 523791004295 active site 523791004296 carbon storage regulator; Provisional; Region: PRK01712 523791004297 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 523791004298 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 523791004299 motif 1; other site 523791004300 active site 523791004301 motif 2; other site 523791004302 motif 3; other site 523791004303 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 523791004304 DHHA1 domain; Region: DHHA1; pfam02272 523791004305 recombination regulator RecX; Reviewed; Region: recX; PRK00117 523791004306 recombinase A; Provisional; Region: recA; PRK09354 523791004307 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 523791004308 hexamer interface [polypeptide binding]; other site 523791004309 Walker A motif; other site 523791004310 ATP binding site [chemical binding]; other site 523791004311 Walker B motif; other site 523791004312 Competence-damaged protein; Region: CinA; pfam02464 523791004313 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 523791004314 MutS domain I; Region: MutS_I; pfam01624 523791004315 MutS domain II; Region: MutS_II; pfam05188 523791004316 MutS domain III; Region: MutS_III; pfam05192 523791004317 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 523791004318 Walker A/P-loop; other site 523791004319 ATP binding site [chemical binding]; other site 523791004320 Q-loop/lid; other site 523791004321 ABC transporter signature motif; other site 523791004322 Walker B; other site 523791004323 D-loop; other site 523791004324 H-loop/switch region; other site 523791004325 Ferredoxin [Energy production and conversion]; Region: COG1146 523791004326 4Fe-4S binding domain; Region: Fer4; cl02805 523791004327 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 523791004328 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791004329 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791004330 Amidohydrolase; Region: Amidohydro_4; pfam13147 523791004331 active site 523791004332 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 523791004333 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 523791004334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 523791004335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791004336 methionine gamma-lyase; Provisional; Region: PRK06234 523791004337 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523791004338 homodimer interface [polypeptide binding]; other site 523791004339 substrate-cofactor binding pocket; other site 523791004340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791004341 catalytic residue [active] 523791004342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 523791004343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523791004344 putative DNA binding site [nucleotide binding]; other site 523791004345 putative Zn2+ binding site [ion binding]; other site 523791004346 AsnC family; Region: AsnC_trans_reg; pfam01037 523791004347 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 523791004348 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 523791004349 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791004350 Chorismate mutase type II; Region: CM_2; pfam01817 523791004351 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523791004352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791004353 S-adenosylmethionine binding site [chemical binding]; other site 523791004354 Putative methyltransferase; Region: Methyltransf_4; cl17290 523791004355 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523791004356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791004357 S-adenosylmethionine binding site [chemical binding]; other site 523791004358 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523791004359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523791004360 active site 523791004361 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 523791004362 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 523791004363 Predicted transcriptional regulator [Transcription]; Region: COG2378 523791004364 WYL domain; Region: WYL; pfam13280 523791004365 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 523791004366 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 523791004367 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 523791004368 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 523791004369 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 523791004370 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 523791004371 rRNA binding site [nucleotide binding]; other site 523791004372 predicted 30S ribosome binding site; other site 523791004373 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 523791004374 Clp amino terminal domain; Region: Clp_N; pfam02861 523791004375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791004376 Walker A motif; other site 523791004377 ATP binding site [chemical binding]; other site 523791004378 Walker B motif; other site 523791004379 arginine finger; other site 523791004380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791004381 Walker A motif; other site 523791004382 ATP binding site [chemical binding]; other site 523791004383 Walker B motif; other site 523791004384 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523791004385 Uncharacterized conserved protein [Function unknown]; Region: COG2127 523791004386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523791004387 catalytic core [active] 523791004388 hypothetical protein; Provisional; Region: PRK05208 523791004389 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 523791004390 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 523791004391 Uncharacterized conserved protein [Function unknown]; Region: COG2128 523791004392 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 523791004393 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 523791004394 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 523791004395 active site 523791004396 Zn binding site [ion binding]; other site 523791004397 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 523791004398 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 523791004399 proposed catalytic triad [active] 523791004400 active site nucleophile [active] 523791004401 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 523791004402 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523791004403 HIGH motif; other site 523791004404 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523791004405 active site 523791004406 KMSKS motif; other site 523791004407 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 523791004408 FAD binding domain; Region: FAD_binding_4; pfam01565 523791004409 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 523791004410 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 523791004411 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 523791004412 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791004413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791004414 metal binding site [ion binding]; metal-binding site 523791004415 active site 523791004416 I-site; other site 523791004417 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523791004418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 523791004419 putative acyl-acceptor binding pocket; other site 523791004420 amidophosphoribosyltransferase; Provisional; Region: PRK09246 523791004421 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 523791004422 active site 523791004423 tetramer interface [polypeptide binding]; other site 523791004424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791004425 active site 523791004426 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 523791004427 Colicin V production protein; Region: Colicin_V; cl00567 523791004428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 523791004429 Sporulation related domain; Region: SPOR; pfam05036 523791004430 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 523791004431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523791004432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523791004433 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 523791004434 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 523791004435 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 523791004436 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 523791004437 dimerization interface 3.5A [polypeptide binding]; other site 523791004438 active site 523791004439 FimV N-terminal domain; Region: FimV_core; TIGR03505 523791004440 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 523791004441 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 523791004442 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 523791004443 aminopeptidase N; Provisional; Region: pepN; PRK14015 523791004444 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 523791004445 active site 523791004446 Zn binding site [ion binding]; other site 523791004447 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 523791004448 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 523791004449 TPP-binding site [chemical binding]; other site 523791004450 tetramer interface [polypeptide binding]; other site 523791004451 heterodimer interface [polypeptide binding]; other site 523791004452 phosphorylation loop region [posttranslational modification] 523791004453 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 523791004454 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 523791004455 alpha subunit interface [polypeptide binding]; other site 523791004456 TPP binding site [chemical binding]; other site 523791004457 heterodimer interface [polypeptide binding]; other site 523791004458 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523791004459 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791004460 E3 interaction surface; other site 523791004461 lipoyl attachment site [posttranslational modification]; other site 523791004462 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791004463 E3 interaction surface; other site 523791004464 lipoyl attachment site [posttranslational modification]; other site 523791004465 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 523791004466 e3 binding domain; Region: E3_binding; pfam02817 523791004467 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523791004468 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 523791004469 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791004470 gamma-glutamyl kinase; Provisional; Region: PRK05429 523791004471 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 523791004472 nucleotide binding site [chemical binding]; other site 523791004473 homotetrameric interface [polypeptide binding]; other site 523791004474 putative phosphate binding site [ion binding]; other site 523791004475 putative allosteric binding site; other site 523791004476 gamma-glutamyl kinase; Provisional; Region: PRK05429 523791004477 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 523791004478 nucleotide binding site [chemical binding]; other site 523791004479 homotetrameric interface [polypeptide binding]; other site 523791004480 putative phosphate binding site [ion binding]; other site 523791004481 putative allosteric binding site; other site 523791004482 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 523791004483 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 523791004484 putative catalytic cysteine [active] 523791004485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523791004486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791004487 non-specific DNA binding site [nucleotide binding]; other site 523791004488 salt bridge; other site 523791004489 sequence-specific DNA binding site [nucleotide binding]; other site 523791004490 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 523791004491 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 523791004492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 523791004493 catalytic loop [active] 523791004494 iron binding site [ion binding]; other site 523791004495 chaperone protein HscA; Provisional; Region: hscA; PRK05183 523791004496 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 523791004497 nucleotide binding site [chemical binding]; other site 523791004498 putative NEF/HSP70 interaction site [polypeptide binding]; other site 523791004499 SBD interface [polypeptide binding]; other site 523791004500 co-chaperone HscB; Provisional; Region: hscB; PRK05014 523791004501 DnaJ domain; Region: DnaJ; pfam00226 523791004502 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 523791004503 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 523791004504 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 523791004505 trimerization site [polypeptide binding]; other site 523791004506 active site 523791004507 cysteine desulfurase; Provisional; Region: PRK14012 523791004508 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 523791004509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791004510 catalytic residue [active] 523791004511 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 523791004512 Rrf2 family protein; Region: rrf2_super; TIGR00738 523791004513 serine O-acetyltransferase; Region: cysE; TIGR01172 523791004514 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 523791004515 trimer interface [polypeptide binding]; other site 523791004516 active site 523791004517 substrate binding site [chemical binding]; other site 523791004518 CoA binding site [chemical binding]; other site 523791004519 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 523791004520 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523791004521 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 523791004522 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 523791004523 active site 523791004524 dimerization interface [polypeptide binding]; other site 523791004525 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 523791004526 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 523791004527 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 523791004528 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 523791004529 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 523791004530 Ligand binding site [chemical binding]; other site 523791004531 Electron transfer flavoprotein domain; Region: ETF; pfam01012 523791004532 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 523791004533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791004534 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 523791004535 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 523791004536 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 523791004537 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 523791004538 maleylacetoacetate isomerase; Region: maiA; TIGR01262 523791004539 C-terminal domain interface [polypeptide binding]; other site 523791004540 GSH binding site (G-site) [chemical binding]; other site 523791004541 putative dimer interface [polypeptide binding]; other site 523791004542 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 523791004543 dimer interface [polypeptide binding]; other site 523791004544 N-terminal domain interface [polypeptide binding]; other site 523791004545 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 523791004546 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 523791004547 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 523791004548 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 523791004549 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 523791004550 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 523791004551 dimer interface [polypeptide binding]; other site 523791004552 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 523791004553 active site 523791004554 Fe binding site [ion binding]; other site 523791004555 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 523791004556 cofactor binding site; other site 523791004557 metal binding site [ion binding]; metal-binding site 523791004558 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 523791004559 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791004560 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791004561 catalytic residue [active] 523791004562 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 523791004563 ligand binding site [chemical binding]; other site 523791004564 active site 523791004565 UGI interface [polypeptide binding]; other site 523791004566 catalytic site [active] 523791004567 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 523791004568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 523791004569 Response regulator receiver domain; Region: Response_reg; pfam00072 523791004570 active site 523791004571 phosphorylation site [posttranslational modification] 523791004572 dimerization interface [polypeptide binding]; other site 523791004573 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 523791004574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791004575 active site 523791004576 imidazolonepropionase; Validated; Region: PRK09356 523791004577 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 523791004578 active site 523791004579 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 523791004580 N-formylglutamate amidohydrolase; Region: FGase; cl01522 523791004581 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 523791004582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523791004583 DNA-binding site [nucleotide binding]; DNA binding site 523791004584 UTRA domain; Region: UTRA; pfam07702 523791004585 urocanate hydratase; Provisional; Region: PRK05414 523791004586 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 523791004587 active sites [active] 523791004588 tetramer interface [polypeptide binding]; other site 523791004589 YceI-like domain; Region: YceI; smart00867 523791004590 Uncharacterized conserved protein [Function unknown]; Region: COG5316 523791004591 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 523791004592 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791004593 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523791004594 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791004595 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791004596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791004597 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 523791004598 CoA binding domain; Region: CoA_binding; smart00881 523791004599 CoA-ligase; Region: Ligase_CoA; pfam00549 523791004600 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 523791004601 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 523791004602 CoA-ligase; Region: Ligase_CoA; pfam00549 523791004603 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 523791004604 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791004605 E3 interaction surface; other site 523791004606 lipoyl attachment site [posttranslational modification]; other site 523791004607 e3 binding domain; Region: E3_binding; pfam02817 523791004608 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523791004609 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 523791004610 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 523791004611 TPP-binding site [chemical binding]; other site 523791004612 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 523791004613 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 523791004614 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 523791004615 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 523791004616 L-aspartate oxidase; Provisional; Region: PRK06175 523791004617 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 523791004618 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 523791004619 SdhC subunit interface [polypeptide binding]; other site 523791004620 proximal heme binding site [chemical binding]; other site 523791004621 cardiolipin binding site; other site 523791004622 Iron-sulfur protein interface; other site 523791004623 proximal quinone binding site [chemical binding]; other site 523791004624 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 523791004625 Iron-sulfur protein interface; other site 523791004626 proximal quinone binding site [chemical binding]; other site 523791004627 SdhD (CybS) interface [polypeptide binding]; other site 523791004628 proximal heme binding site [chemical binding]; other site 523791004629 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 523791004630 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 523791004631 dimer interface [polypeptide binding]; other site 523791004632 active site 523791004633 citrylCoA binding site [chemical binding]; other site 523791004634 NADH binding [chemical binding]; other site 523791004635 cationic pore residues; other site 523791004636 oxalacetate/citrate binding site [chemical binding]; other site 523791004637 coenzyme A binding site [chemical binding]; other site 523791004638 catalytic triad [active] 523791004639 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 523791004640 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 523791004641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791004642 putative metal binding site [ion binding]; other site 523791004643 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 523791004644 GAF domain; Region: GAF_2; pfam13185 523791004645 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 523791004646 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 523791004647 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 523791004648 putative dimer interface [polypeptide binding]; other site 523791004649 putative anticodon binding site; other site 523791004650 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 523791004651 homodimer interface [polypeptide binding]; other site 523791004652 motif 1; other site 523791004653 motif 2; other site 523791004654 active site 523791004655 motif 3; other site 523791004656 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 523791004657 putative FMN binding site [chemical binding]; other site 523791004658 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 523791004659 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 523791004660 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791004661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523791004662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 523791004663 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791004664 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 523791004665 Protein export membrane protein; Region: SecD_SecF; cl14618 523791004666 pyruvate kinase; Provisional; Region: PRK05826 523791004667 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 523791004668 domain interfaces; other site 523791004669 active site 523791004670 EamA-like transporter family; Region: EamA; pfam00892 523791004671 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 523791004672 EamA-like transporter family; Region: EamA; pfam00892 523791004673 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 523791004674 putative active site [active] 523791004675 putative catalytic site [active] 523791004676 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 523791004677 active site 2 [active] 523791004678 active site 1 [active] 523791004679 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 523791004680 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 523791004681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523791004682 acyl-activating enzyme (AAE) consensus motif; other site 523791004683 AMP binding site [chemical binding]; other site 523791004684 active site 523791004685 CoA binding site [chemical binding]; other site 523791004686 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 523791004687 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 523791004688 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 523791004689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523791004690 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 523791004691 Walker A/P-loop; other site 523791004692 ATP binding site [chemical binding]; other site 523791004693 Q-loop/lid; other site 523791004694 ABC transporter signature motif; other site 523791004695 Walker B; other site 523791004696 D-loop; other site 523791004697 H-loop/switch region; other site 523791004698 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523791004699 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 523791004700 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 523791004701 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 523791004702 putative ligand binding site [chemical binding]; other site 523791004703 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 523791004704 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 523791004705 FAD binding pocket [chemical binding]; other site 523791004706 conserved FAD binding motif [chemical binding]; other site 523791004707 phosphate binding motif [ion binding]; other site 523791004708 beta-alpha-beta structure motif; other site 523791004709 NAD binding pocket [chemical binding]; other site 523791004710 Nudix hydrolase homolog; Region: PLN02791 523791004711 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 523791004712 DsrE/DsrF-like family; Region: DrsE; cl00672 523791004713 DsrH like protein; Region: DsrH; pfam04077 523791004714 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 523791004715 DsrC like protein; Region: DsrC; pfam04358 523791004716 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 523791004717 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 523791004718 catalytic triad [active] 523791004719 dimer interface [polypeptide binding]; other site 523791004720 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 523791004721 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 523791004722 PspC domain; Region: PspC; pfam04024 523791004723 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 523791004724 Chorismate mutase type II; Region: CM_2; smart00830 523791004725 Prephenate dehydratase; Region: PDT; pfam00800 523791004726 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 523791004727 putative L-Phe binding site [chemical binding]; other site 523791004728 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 523791004729 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 523791004730 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 523791004731 hypothetical protein; Provisional; Region: PRK09256 523791004732 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 523791004733 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 523791004734 active site residue [active] 523791004735 Protein of unknown function DUF45; Region: DUF45; pfam01863 523791004736 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 523791004737 GIY-YIG motif/motif A; other site 523791004738 putative active site [active] 523791004739 putative metal binding site [ion binding]; other site 523791004740 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 523791004741 NlpC/P60 family; Region: NLPC_P60; pfam00877 523791004742 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 523791004743 serine/threonine protein kinase; Provisional; Region: PRK11768 523791004744 Protein of unknown function (DUF502); Region: DUF502; pfam04367 523791004745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 523791004746 Protein of unknown function, DUF482; Region: DUF482; pfam04339 523791004747 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 523791004748 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 523791004749 active site 523791004750 Zn binding site [ion binding]; other site 523791004751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523791004752 TPR motif; other site 523791004753 binding surface 523791004754 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791004755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791004756 binding surface 523791004757 TPR motif; other site 523791004758 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 523791004759 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 523791004760 PhnA protein; Region: PhnA; pfam03831 523791004761 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 523791004762 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 523791004763 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523791004764 N-terminal plug; other site 523791004765 ligand-binding site [chemical binding]; other site 523791004766 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 523791004767 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 523791004768 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523791004769 N-terminal plug; other site 523791004770 ligand-binding site [chemical binding]; other site 523791004771 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 523791004772 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 523791004773 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 523791004774 substrate binding pocket [chemical binding]; other site 523791004775 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 523791004776 B12 binding site [chemical binding]; other site 523791004777 cobalt ligand [ion binding]; other site 523791004778 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 523791004779 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 523791004780 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 523791004781 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791004782 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 523791004783 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 523791004784 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 523791004785 FAD binding site [chemical binding]; other site 523791004786 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 523791004787 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 523791004788 nucleotide binding site [chemical binding]; other site 523791004789 substrate binding site [chemical binding]; other site 523791004790 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523791004791 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 523791004792 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 523791004793 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 523791004794 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523791004795 homodimer interface [polypeptide binding]; other site 523791004796 substrate-cofactor binding pocket; other site 523791004797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791004798 catalytic residue [active] 523791004799 homoserine O-acetyltransferase; Provisional; Region: PRK08775 523791004800 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 523791004801 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 523791004802 dimerization interface [polypeptide binding]; other site 523791004803 DNA binding site [nucleotide binding] 523791004804 corepressor binding sites; other site 523791004805 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 523791004806 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523791004807 dimer interface [polypeptide binding]; other site 523791004808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791004809 catalytic residue [active] 523791004810 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 523791004811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791004812 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 523791004813 substrate binding site [chemical binding]; other site 523791004814 dimerization interface [polypeptide binding]; other site 523791004815 Predicted methyltransferase [General function prediction only]; Region: COG4798 523791004816 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523791004817 quinolinate synthetase; Provisional; Region: PRK09375 523791004818 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 523791004819 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791004820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791004821 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 523791004822 NAD(P) binding site [chemical binding]; other site 523791004823 active site 523791004824 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 523791004825 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 523791004826 active site 523791004827 Zn binding site [ion binding]; other site 523791004828 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 523791004829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791004830 active site 523791004831 phosphorylation site [posttranslational modification] 523791004832 intermolecular recognition site; other site 523791004833 dimerization interface [polypeptide binding]; other site 523791004834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791004835 DNA binding site [nucleotide binding] 523791004836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791004837 dimer interface [polypeptide binding]; other site 523791004838 phosphorylation site [posttranslational modification] 523791004839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791004840 ATP binding site [chemical binding]; other site 523791004841 Mg2+ binding site [ion binding]; other site 523791004842 G-X-G motif; other site 523791004843 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 523791004844 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 523791004845 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 523791004846 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 523791004847 dihydrodipicolinate synthase; Region: dapA; TIGR00674 523791004848 dimer interface [polypeptide binding]; other site 523791004849 active site 523791004850 catalytic residue [active] 523791004851 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 523791004852 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 523791004853 catalytic triad [active] 523791004854 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 523791004855 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 523791004856 putative active site [active] 523791004857 PhoH-like protein; Region: PhoH; pfam02562 523791004858 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791004859 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791004860 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 523791004861 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 523791004862 Domain of unknown function DUF20; Region: UPF0118; pfam01594 523791004863 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 523791004864 Peptidase family M48; Region: Peptidase_M48; pfam01435 523791004865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791004866 binding surface 523791004867 TPR motif; other site 523791004868 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523791004869 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791004870 catalytic residues [active] 523791004871 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 523791004872 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 523791004873 ArsC family; Region: ArsC; pfam03960 523791004874 catalytic residues [active] 523791004875 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523791004876 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 523791004877 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 523791004878 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 523791004879 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 523791004880 Tetramer interface [polypeptide binding]; other site 523791004881 active site 523791004882 FMN-binding site [chemical binding]; other site 523791004883 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 523791004884 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 523791004885 hinge; other site 523791004886 active site 523791004887 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 523791004888 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 523791004889 substrate binding site [chemical binding]; other site 523791004890 active site 523791004891 catalytic residues [active] 523791004892 heterodimer interface [polypeptide binding]; other site 523791004893 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 523791004894 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 523791004895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791004896 catalytic residue [active] 523791004897 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 523791004898 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 523791004899 active site 523791004900 ribulose/triose binding site [chemical binding]; other site 523791004901 phosphate binding site [ion binding]; other site 523791004902 substrate (anthranilate) binding pocket [chemical binding]; other site 523791004903 product (indole) binding pocket [chemical binding]; other site 523791004904 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 523791004905 active site 523791004906 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 523791004907 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523791004908 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523791004909 Glutamine amidotransferase class-I; Region: GATase; pfam00117 523791004910 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 523791004911 glutamine binding [chemical binding]; other site 523791004912 catalytic triad [active] 523791004913 anthranilate synthase component I; Provisional; Region: PRK13564 523791004914 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 523791004915 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 523791004916 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 523791004917 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 523791004918 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 523791004919 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 523791004920 P-loop; other site 523791004921 Magnesium ion binding site [ion binding]; other site 523791004922 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 523791004923 metal ion-dependent adhesion site (MIDAS); other site 523791004924 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 523791004925 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 523791004926 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 523791004927 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 523791004928 Type II transport protein GspH; Region: GspH; pfam12019 523791004929 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 523791004930 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 523791004931 Type II transport protein GspH; Region: GspH; pfam12019 523791004932 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 523791004933 PilX N-terminal; Region: PilX_N; pfam14341 523791004934 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 523791004935 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 523791004936 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 523791004937 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 523791004938 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791004939 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 523791004940 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 523791004941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523791004942 active site 523791004943 HIGH motif; other site 523791004944 nucleotide binding site [chemical binding]; other site 523791004945 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523791004946 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 523791004947 active site 523791004948 KMSKS motif; other site 523791004949 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 523791004950 tRNA binding surface [nucleotide binding]; other site 523791004951 anticodon binding site; other site 523791004952 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 523791004953 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 523791004954 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 523791004955 active site 523791004956 Riboflavin kinase; Region: Flavokinase; smart00904 523791004957 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 523791004958 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 523791004959 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 523791004960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523791004961 MarR family; Region: MarR; pfam01047 523791004962 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 523791004963 DsrE/DsrF-like family; Region: DrsE; pfam02635 523791004964 GTPase CgtA; Reviewed; Region: obgE; PRK12298 523791004965 GTP1/OBG; Region: GTP1_OBG; pfam01018 523791004966 Obg GTPase; Region: Obg; cd01898 523791004967 G1 box; other site 523791004968 GTP/Mg2+ binding site [chemical binding]; other site 523791004969 Switch I region; other site 523791004970 G2 box; other site 523791004971 G3 box; other site 523791004972 Switch II region; other site 523791004973 G4 box; other site 523791004974 G5 box; other site 523791004975 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 523791004976 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 523791004977 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 523791004978 Uncharacterized conserved protein [Function unknown]; Region: COG3743 523791004979 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 523791004980 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 523791004981 substrate binding pocket [chemical binding]; other site 523791004982 chain length determination region; other site 523791004983 substrate-Mg2+ binding site; other site 523791004984 catalytic residues [active] 523791004985 aspartate-rich region 1; other site 523791004986 active site lid residues [active] 523791004987 aspartate-rich region 2; other site 523791004988 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 523791004989 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 523791004990 active site 523791004991 substrate-binding site [chemical binding]; other site 523791004992 metal-binding site [ion binding] 523791004993 ATP binding site [chemical binding]; other site 523791004994 CHASE domain; Region: CHASE; pfam03924 523791004995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791004996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791004997 metal binding site [ion binding]; metal-binding site 523791004998 active site 523791004999 I-site; other site 523791005000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791005001 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 523791005002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 523791005003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 523791005004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 523791005005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 523791005006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 523791005007 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 523791005008 cyclase homology domain; Region: CHD; cd07302 523791005009 nucleotidyl binding site; other site 523791005010 metal binding site [ion binding]; metal-binding site 523791005011 dimer interface [polypeptide binding]; other site 523791005012 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 523791005013 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 523791005014 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 523791005015 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 523791005016 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 523791005017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791005018 active site 523791005019 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523791005020 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791005021 ligand binding site [chemical binding]; other site 523791005022 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 523791005023 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 523791005024 dimerization interface [polypeptide binding]; other site 523791005025 putative ATP binding site [chemical binding]; other site 523791005026 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 523791005027 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 523791005028 active site 523791005029 substrate binding site [chemical binding]; other site 523791005030 cosubstrate binding site; other site 523791005031 catalytic site [active] 523791005032 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 523791005033 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 523791005034 trimer interface [polypeptide binding]; other site 523791005035 active site 523791005036 Domain of unknown function DUF59; Region: DUF59; pfam01883 523791005037 antiporter inner membrane protein; Provisional; Region: PRK11670 523791005038 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 523791005039 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 523791005040 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 523791005041 active site 523791005042 HIGH motif; other site 523791005043 KMSKS motif; other site 523791005044 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 523791005045 tRNA binding surface [nucleotide binding]; other site 523791005046 anticodon binding site; other site 523791005047 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 523791005048 dimer interface [polypeptide binding]; other site 523791005049 putative tRNA-binding site [nucleotide binding]; other site 523791005050 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 523791005051 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 523791005052 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 523791005053 Chorismate mutase type II; Region: CM_2; smart00830 523791005054 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523791005055 Peptidase family U32; Region: Peptidase_U32; pfam01136 523791005056 putative protease; Provisional; Region: PRK15447 523791005057 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523791005058 SCP-2 sterol transfer family; Region: SCP2; cl01225 523791005059 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791005060 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 523791005061 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 523791005062 additional DNA contacts [nucleotide binding]; other site 523791005063 mismatch recognition site; other site 523791005064 active site 523791005065 zinc binding site [ion binding]; other site 523791005066 DNA intercalation site [nucleotide binding]; other site 523791005067 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523791005068 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 523791005069 Protein of unknown function (DUF524); Region: DUF524; pfam04411 523791005070 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 523791005071 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 523791005072 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 523791005073 cofactor binding site; other site 523791005074 DNA binding site [nucleotide binding] 523791005075 substrate interaction site [chemical binding]; other site 523791005076 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 523791005077 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 523791005078 DNA binding residues [nucleotide binding] 523791005079 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523791005080 IHF - DNA interface [nucleotide binding]; other site 523791005081 IHF dimer interface [polypeptide binding]; other site 523791005082 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 523791005083 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 523791005084 putative tRNA-binding site [nucleotide binding]; other site 523791005085 B3/4 domain; Region: B3_4; pfam03483 523791005086 tRNA synthetase B5 domain; Region: B5; smart00874 523791005087 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 523791005088 dimer interface [polypeptide binding]; other site 523791005089 motif 1; other site 523791005090 motif 3; other site 523791005091 motif 2; other site 523791005092 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 523791005093 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 523791005094 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 523791005095 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 523791005096 dimer interface [polypeptide binding]; other site 523791005097 motif 1; other site 523791005098 active site 523791005099 motif 2; other site 523791005100 motif 3; other site 523791005101 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 523791005102 23S rRNA binding site [nucleotide binding]; other site 523791005103 L21 binding site [polypeptide binding]; other site 523791005104 L13 binding site [polypeptide binding]; other site 523791005105 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 523791005106 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 523791005107 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 523791005108 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 523791005109 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 523791005110 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 523791005111 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 523791005112 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 523791005113 active site 523791005114 dimer interface [polypeptide binding]; other site 523791005115 motif 1; other site 523791005116 motif 2; other site 523791005117 motif 3; other site 523791005118 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 523791005119 anticodon binding site; other site 523791005120 Uncharacterized conserved protein [Function unknown]; Region: COG3791 523791005121 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 523791005122 GIY-YIG motif/motif A; other site 523791005123 putative active site [active] 523791005124 putative metal binding site [ion binding]; other site 523791005125 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 523791005126 Pirin-related protein [General function prediction only]; Region: COG1741 523791005127 Pirin; Region: Pirin; pfam02678 523791005128 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 523791005129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791005130 PAS domain; Region: PAS_9; pfam13426 523791005131 putative active site [active] 523791005132 heme pocket [chemical binding]; other site 523791005133 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791005134 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791005135 metal binding site [ion binding]; metal-binding site 523791005136 active site 523791005137 I-site; other site 523791005138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791005139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 523791005140 active site 523791005141 metal binding site [ion binding]; metal-binding site 523791005142 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 523791005143 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 523791005144 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 523791005145 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 523791005146 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 523791005147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791005148 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523791005149 SdiA-regulated; Region: SdiA-regulated; cd09971 523791005150 putative active site [active] 523791005151 Calx-beta domain; Region: Calx-beta; cl02522 523791005152 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791005153 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 523791005154 dimer interface [polypeptide binding]; other site 523791005155 active site 523791005156 metal binding site [ion binding]; metal-binding site 523791005157 glutathione binding site [chemical binding]; other site 523791005158 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 523791005159 active site 523791005160 substrate binding pocket [chemical binding]; other site 523791005161 dimer interface [polypeptide binding]; other site 523791005162 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 523791005163 ribonuclease T; Provisional; Region: PRK05168 523791005164 active site 523791005165 catalytic site [active] 523791005166 substrate binding site [chemical binding]; other site 523791005167 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 523791005168 catalytic nucleophile [active] 523791005169 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 523791005170 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 523791005171 peroxidase; Provisional; Region: PRK15000 523791005172 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 523791005173 dimer interface [polypeptide binding]; other site 523791005174 decamer (pentamer of dimers) interface [polypeptide binding]; other site 523791005175 catalytic triad [active] 523791005176 peroxidatic and resolving cysteines [active] 523791005177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523791005178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791005179 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 523791005180 substrate binding pocket [chemical binding]; other site 523791005181 dimerization interface [polypeptide binding]; other site 523791005182 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 523791005183 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 523791005184 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 523791005185 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 523791005186 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 523791005187 heme binding site [chemical binding]; other site 523791005188 ferroxidase pore; other site 523791005189 ferroxidase diiron center [ion binding]; other site 523791005190 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 523791005191 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 523791005192 active site 523791005193 catalytic site [active] 523791005194 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 523791005195 putative metal binding site [ion binding]; other site 523791005196 Uncharacterized conserved protein [Function unknown]; Region: COG1432 523791005197 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 523791005198 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 523791005199 putative GSH binding site [chemical binding]; other site 523791005200 catalytic residues [active] 523791005201 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 523791005202 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 523791005203 Walker A/P-loop; other site 523791005204 ATP binding site [chemical binding]; other site 523791005205 Q-loop/lid; other site 523791005206 ABC transporter signature motif; other site 523791005207 Walker B; other site 523791005208 D-loop; other site 523791005209 H-loop/switch region; other site 523791005210 TOBE domain; Region: TOBE_2; pfam08402 523791005211 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 523791005212 ATP cone domain; Region: ATP-cone; pfam03477 523791005213 ATP cone domain; Region: ATP-cone; pfam03477 523791005214 Class I ribonucleotide reductase; Region: RNR_I; cd01679 523791005215 active site 523791005216 dimer interface [polypeptide binding]; other site 523791005217 catalytic residues [active] 523791005218 effector binding site; other site 523791005219 R2 peptide binding site; other site 523791005220 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 523791005221 dimer interface [polypeptide binding]; other site 523791005222 putative radical transfer pathway; other site 523791005223 diiron center [ion binding]; other site 523791005224 tyrosyl radical; other site 523791005225 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 523791005226 Nuclease-related domain; Region: NERD; pfam08378 523791005227 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 523791005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791005229 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 523791005230 DNA binding residues [nucleotide binding] 523791005231 Protein of unknown function, DUF607; Region: DUF607; pfam04678 523791005232 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 523791005233 Beta-lactamase; Region: Beta-lactamase; pfam00144 523791005234 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791005235 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791005236 metal binding site [ion binding]; metal-binding site 523791005237 active site 523791005238 I-site; other site 523791005239 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791005240 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 523791005241 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 523791005242 Ion channel; Region: Ion_trans_2; pfam07885 523791005243 superoxide dismutase; Provisional; Region: PRK10543 523791005244 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 523791005245 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 523791005246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791005247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523791005248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791005249 non-specific DNA binding site [nucleotide binding]; other site 523791005250 salt bridge; other site 523791005251 sequence-specific DNA binding site [nucleotide binding]; other site 523791005252 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 523791005253 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523791005254 homodimer interface [polypeptide binding]; other site 523791005255 substrate-cofactor binding pocket; other site 523791005256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791005257 catalytic residue [active] 523791005258 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 523791005259 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523791005260 dimer interface [polypeptide binding]; other site 523791005261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791005262 catalytic residue [active] 523791005263 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 523791005264 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 523791005265 TPP-binding site [chemical binding]; other site 523791005266 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 523791005267 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 523791005268 alpha subunit interface [polypeptide binding]; other site 523791005269 TPP binding site [chemical binding]; other site 523791005270 heterodimer interface [polypeptide binding]; other site 523791005271 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523791005272 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 523791005273 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791005274 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 523791005275 calcium binding site 2 [ion binding]; other site 523791005276 active site 523791005277 catalytic triad [active] 523791005278 calcium binding site 1 [ion binding]; other site 523791005279 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791005280 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791005281 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 523791005282 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 523791005283 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 523791005284 Predicted flavoproteins [General function prediction only]; Region: COG2081 523791005285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791005286 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 523791005287 EamA-like transporter family; Region: EamA; pfam00892 523791005288 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 523791005289 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 523791005290 active site 523791005291 Zn binding site [ion binding]; other site 523791005292 fumarate hydratase; Reviewed; Region: fumC; PRK00485 523791005293 Class II fumarases; Region: Fumarase_classII; cd01362 523791005294 active site 523791005295 tetramer interface [polypeptide binding]; other site 523791005296 SlyX; Region: SlyX; pfam04102 523791005297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 523791005298 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 523791005299 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523791005300 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 523791005301 Walker A/P-loop; other site 523791005302 ATP binding site [chemical binding]; other site 523791005303 Q-loop/lid; other site 523791005304 ABC transporter signature motif; other site 523791005305 Walker B; other site 523791005306 D-loop; other site 523791005307 H-loop/switch region; other site 523791005308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 523791005309 SEC-C motif; Region: SEC-C; pfam02810 523791005310 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 523791005311 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 523791005312 UbiA prenyltransferase family; Region: UbiA; pfam01040 523791005313 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 523791005314 GIY-YIG motif/motif A; other site 523791005315 putative active site [active] 523791005316 putative metal binding site [ion binding]; other site 523791005317 Putative exonuclease, RdgC; Region: RdgC; cl01122 523791005318 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 523791005319 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 523791005320 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791005321 Pilin (bacterial filament); Region: Pilin; pfam00114 523791005322 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 523791005323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 523791005324 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 523791005325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523791005326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791005327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 523791005328 dimerization interface [polypeptide binding]; other site 523791005329 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 523791005330 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 523791005331 putative NAD(P) binding site [chemical binding]; other site 523791005332 homodimer interface [polypeptide binding]; other site 523791005333 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 523791005334 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 523791005335 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 523791005336 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 523791005337 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523791005338 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791005339 ligand binding site [chemical binding]; other site 523791005340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791005341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791005342 metal binding site [ion binding]; metal-binding site 523791005343 active site 523791005344 I-site; other site 523791005345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 523791005346 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 523791005347 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 523791005348 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 523791005349 Peptidase M15; Region: Peptidase_M15_3; cl01194 523791005350 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 523791005351 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 523791005352 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 523791005353 catalytic triad [active] 523791005354 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 523791005355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 523791005356 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 523791005357 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 523791005358 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 523791005359 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 523791005360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791005361 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 523791005362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791005363 non-specific DNA binding site [nucleotide binding]; other site 523791005364 salt bridge; other site 523791005365 sequence-specific DNA binding site [nucleotide binding]; other site 523791005366 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 523791005367 RDD family; Region: RDD; pfam06271 523791005368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791005369 S-adenosylmethionine binding site [chemical binding]; other site 523791005370 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 523791005371 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 523791005372 Predicted permeases [General function prediction only]; Region: COG0795 523791005373 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 523791005374 multifunctional aminopeptidase A; Provisional; Region: PRK00913 523791005375 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 523791005376 interface (dimer of trimers) [polypeptide binding]; other site 523791005377 Substrate-binding/catalytic site; other site 523791005378 Zn-binding sites [ion binding]; other site 523791005379 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 523791005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791005381 S-adenosylmethionine binding site [chemical binding]; other site 523791005382 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 523791005383 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 523791005384 HIGH motif; other site 523791005385 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523791005386 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 523791005387 active site 523791005388 KMSKS motif; other site 523791005389 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 523791005390 tRNA binding surface [nucleotide binding]; other site 523791005391 anticodon binding site; other site 523791005392 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 523791005393 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523791005394 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 523791005395 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 523791005396 nucleotide binding site [chemical binding]; other site 523791005397 substrate binding site [chemical binding]; other site 523791005398 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 523791005399 dimer interface [polypeptide binding]; other site 523791005400 allosteric regulatory binding pocket; other site 523791005401 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523791005402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 523791005403 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523791005404 catalytic residue [active] 523791005405 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 523791005406 nucleoside/Zn binding site; other site 523791005407 dimer interface [polypeptide binding]; other site 523791005408 catalytic motif [active] 523791005409 GMP synthase; Reviewed; Region: guaA; PRK00074 523791005410 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 523791005411 AMP/PPi binding site [chemical binding]; other site 523791005412 candidate oxyanion hole; other site 523791005413 catalytic triad [active] 523791005414 potential glutamine specificity residues [chemical binding]; other site 523791005415 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 523791005416 ATP Binding subdomain [chemical binding]; other site 523791005417 Ligand Binding sites [chemical binding]; other site 523791005418 Dimerization subdomain; other site 523791005419 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 523791005420 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 523791005421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 523791005422 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 523791005423 active site 523791005424 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 523791005425 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 523791005426 generic binding surface II; other site 523791005427 generic binding surface I; other site 523791005428 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 523791005429 GTP-binding protein Der; Reviewed; Region: PRK00093 523791005430 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 523791005431 G1 box; other site 523791005432 GTP/Mg2+ binding site [chemical binding]; other site 523791005433 Switch I region; other site 523791005434 G2 box; other site 523791005435 Switch II region; other site 523791005436 G3 box; other site 523791005437 G4 box; other site 523791005438 G5 box; other site 523791005439 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 523791005440 G1 box; other site 523791005441 GTP/Mg2+ binding site [chemical binding]; other site 523791005442 Switch I region; other site 523791005443 G2 box; other site 523791005444 G3 box; other site 523791005445 Switch II region; other site 523791005446 G4 box; other site 523791005447 G5 box; other site 523791005448 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 523791005449 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 523791005450 Trp docking motif [polypeptide binding]; other site 523791005451 active site 523791005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 523791005453 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 523791005454 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 523791005455 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 523791005456 dimer interface [polypeptide binding]; other site 523791005457 motif 1; other site 523791005458 active site 523791005459 motif 2; other site 523791005460 motif 3; other site 523791005461 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 523791005462 anticodon binding site; other site 523791005463 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 523791005464 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 523791005465 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 523791005466 cytoskeletal protein RodZ; Provisional; Region: PRK10856 523791005467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791005468 non-specific DNA binding site [nucleotide binding]; other site 523791005469 salt bridge; other site 523791005470 sequence-specific DNA binding site [nucleotide binding]; other site 523791005471 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 523791005472 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 523791005473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791005474 binding surface 523791005475 TPR motif; other site 523791005476 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 523791005477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791005478 FeS/SAM binding site; other site 523791005479 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 523791005480 active site 523791005481 multimer interface [polypeptide binding]; other site 523791005482 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 523791005483 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 523791005484 Ligand Binding Site [chemical binding]; other site 523791005485 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 523791005486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791005487 FeS/SAM binding site; other site 523791005488 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 523791005489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791005490 binding surface 523791005491 TPR motif; other site 523791005492 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523791005493 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791005494 ligand binding site [chemical binding]; other site 523791005495 translocation protein TolB; Provisional; Region: tolB; PRK04792 523791005496 TolB amino-terminal domain; Region: TolB_N; pfam04052 523791005497 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 523791005498 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 523791005499 TolA protein; Region: tolA_full; TIGR02794 523791005500 TolA C-terminal; Region: TolA; pfam06519 523791005501 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523791005502 TolR protein; Region: tolR; TIGR02801 523791005503 TolQ protein; Region: tolQ; TIGR02796 523791005504 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523791005505 active site 523791005506 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 523791005507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791005508 Walker A motif; other site 523791005509 ATP binding site [chemical binding]; other site 523791005510 Walker B motif; other site 523791005511 arginine finger; other site 523791005512 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 523791005513 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 523791005514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791005515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791005516 ABC transporter; Region: ABC_tran_2; pfam12848 523791005517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791005518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 523791005519 CoenzymeA binding site [chemical binding]; other site 523791005520 subunit interaction site [polypeptide binding]; other site 523791005521 PHB binding site; other site 523791005522 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 523791005523 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 523791005524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791005525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791005526 metal binding site [ion binding]; metal-binding site 523791005527 active site 523791005528 I-site; other site 523791005529 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 523791005530 RuvA N terminal domain; Region: RuvA_N; pfam01330 523791005531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 523791005532 helix-hairpin-helix signature motif; other site 523791005533 active site 523791005534 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 523791005535 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 523791005536 active site 523791005537 putative DNA-binding cleft [nucleotide binding]; other site 523791005538 dimer interface [polypeptide binding]; other site 523791005539 hypothetical protein; Validated; Region: PRK00110 523791005540 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 523791005541 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 523791005542 dimer interface [polypeptide binding]; other site 523791005543 anticodon binding site; other site 523791005544 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 523791005545 homodimer interface [polypeptide binding]; other site 523791005546 motif 1; other site 523791005547 active site 523791005548 motif 2; other site 523791005549 GAD domain; Region: GAD; pfam02938 523791005550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523791005551 active site 523791005552 motif 3; other site 523791005553 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 523791005554 putative acyl-acceptor binding pocket; other site 523791005555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 523791005556 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791005557 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791005558 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 523791005559 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 523791005560 metal binding site [ion binding]; metal-binding site 523791005561 dimer interface [polypeptide binding]; other site 523791005562 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 523791005563 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 523791005564 active site 523791005565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791005566 prolyl-tRNA synthetase; Provisional; Region: PRK09194 523791005567 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 523791005568 dimer interface [polypeptide binding]; other site 523791005569 motif 1; other site 523791005570 active site 523791005571 motif 2; other site 523791005572 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 523791005573 putative deacylase active site [active] 523791005574 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523791005575 active site 523791005576 motif 3; other site 523791005577 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 523791005578 anticodon binding site; other site 523791005579 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 523791005580 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791005581 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791005582 catalytic residue [active] 523791005583 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 523791005584 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 523791005585 active site 523791005586 nucleophile elbow; other site 523791005587 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 523791005588 NAD binding site [chemical binding]; other site 523791005589 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 523791005590 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 523791005591 Ligand Binding Site [chemical binding]; other site 523791005592 TilS substrate binding domain; Region: TilS; pfam09179 523791005593 TilS substrate C-terminal domain; Region: TilS_C; smart00977 523791005594 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 523791005595 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 523791005596 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 523791005597 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 523791005598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523791005599 AlkA N-terminal domain; Region: AlkA_N; pfam06029 523791005600 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 523791005601 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523791005602 minor groove reading motif; other site 523791005603 helix-hairpin-helix signature motif; other site 523791005604 substrate binding pocket [chemical binding]; other site 523791005605 active site 523791005606 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 523791005607 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 523791005608 DNA binding site [nucleotide binding] 523791005609 active site 523791005610 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 523791005611 trimer interface [polypeptide binding]; other site 523791005612 active site 523791005613 substrate binding site [chemical binding]; other site 523791005614 CoA binding site [chemical binding]; other site 523791005615 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 523791005616 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 523791005617 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 523791005618 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 523791005619 potential catalytic triad [active] 523791005620 conserved cys residue [active] 523791005621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 523791005622 putative dimer interface [polypeptide binding]; other site 523791005623 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523791005624 ligand binding site [chemical binding]; other site 523791005625 Zn binding site [ion binding]; other site 523791005626 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791005627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791005628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791005629 active site 523791005630 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 523791005631 Prostaglandin dehydrogenases; Region: PGDH; cd05288 523791005632 NAD(P) binding site [chemical binding]; other site 523791005633 substrate binding site [chemical binding]; other site 523791005634 dimer interface [polypeptide binding]; other site 523791005635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523791005636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791005637 non-specific DNA binding site [nucleotide binding]; other site 523791005638 salt bridge; other site 523791005639 sequence-specific DNA binding site [nucleotide binding]; other site 523791005640 2TM domain; Region: 2TM; pfam13239 523791005641 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 523791005642 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 523791005643 putative active site [active] 523791005644 putative PHP Thumb interface [polypeptide binding]; other site 523791005645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 523791005646 generic binding surface II; other site 523791005647 generic binding surface I; other site 523791005648 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 523791005649 RNA/DNA hybrid binding site [nucleotide binding]; other site 523791005650 active site 523791005651 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 523791005652 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 523791005653 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 523791005654 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 523791005655 active site 523791005656 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 523791005657 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 523791005658 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 523791005659 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 523791005660 trimer interface [polypeptide binding]; other site 523791005661 active site 523791005662 UDP-GlcNAc binding site [chemical binding]; other site 523791005663 lipid binding site [chemical binding]; lipid-binding site 523791005664 periplasmic chaperone; Provisional; Region: PRK10780 523791005665 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 523791005666 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 523791005667 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523791005668 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523791005669 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523791005670 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523791005671 Surface antigen; Region: Bac_surface_Ag; pfam01103 523791005672 zinc metallopeptidase RseP; Provisional; Region: PRK10779 523791005673 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 523791005674 active site 523791005675 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 523791005676 protein binding site [polypeptide binding]; other site 523791005677 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 523791005678 protein binding site [polypeptide binding]; other site 523791005679 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 523791005680 putative substrate binding region [chemical binding]; other site 523791005681 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 523791005682 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 523791005683 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 523791005684 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 523791005685 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 523791005686 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 523791005687 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 523791005688 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 523791005689 catalytic residue [active] 523791005690 putative FPP diphosphate binding site; other site 523791005691 putative FPP binding hydrophobic cleft; other site 523791005692 dimer interface [polypeptide binding]; other site 523791005693 putative IPP diphosphate binding site; other site 523791005694 ribosome recycling factor; Reviewed; Region: frr; PRK00083 523791005695 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 523791005696 hinge region; other site 523791005697 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 523791005698 putative nucleotide binding site [chemical binding]; other site 523791005699 uridine monophosphate binding site [chemical binding]; other site 523791005700 homohexameric interface [polypeptide binding]; other site 523791005701 elongation factor Ts; Provisional; Region: tsf; PRK09377 523791005702 UBA/TS-N domain; Region: UBA; pfam00627 523791005703 Elongation factor TS; Region: EF_TS; pfam00889 523791005704 Elongation factor TS; Region: EF_TS; pfam00889 523791005705 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 523791005706 rRNA interaction site [nucleotide binding]; other site 523791005707 S8 interaction site; other site 523791005708 putative laminin-1 binding site; other site 523791005709 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 523791005710 Di-iron ligands [ion binding]; other site 523791005711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 523791005712 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 523791005713 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 523791005714 active site 523791005715 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 523791005716 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 523791005717 metal binding triad; other site 523791005718 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 523791005719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791005720 Zn2+ binding site [ion binding]; other site 523791005721 Mg2+ binding site [ion binding]; other site 523791005722 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 523791005723 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 523791005724 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 523791005725 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 523791005726 trimer interface [polypeptide binding]; other site 523791005727 active site 523791005728 substrate binding site [chemical binding]; other site 523791005729 CoA binding site [chemical binding]; other site 523791005730 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 523791005731 ArsC family; Region: ArsC; pfam03960 523791005732 putative catalytic residues [active] 523791005733 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 523791005734 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 523791005735 metal binding site [ion binding]; metal-binding site 523791005736 dimer interface [polypeptide binding]; other site 523791005737 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 523791005738 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523791005739 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 523791005740 transmembrane helices; other site 523791005741 enoyl-CoA hydratase; Provisional; Region: PRK06688 523791005742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523791005743 substrate binding site [chemical binding]; other site 523791005744 oxyanion hole (OAH) forming residues; other site 523791005745 trimer interface [polypeptide binding]; other site 523791005746 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 523791005747 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 523791005748 active site 523791005749 catalytic site [active] 523791005750 substrate binding site [chemical binding]; other site 523791005751 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 523791005752 RNA/DNA hybrid binding site [nucleotide binding]; other site 523791005753 active site 523791005754 Methyltransferase domain; Region: Methyltransf_11; pfam08241 523791005755 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 523791005756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523791005757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523791005758 catalytic residue [active] 523791005759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791005760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791005761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791005762 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 523791005763 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 523791005764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791005765 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 523791005766 Walker A/P-loop; other site 523791005767 ATP binding site [chemical binding]; other site 523791005768 Q-loop/lid; other site 523791005769 ABC transporter signature motif; other site 523791005770 Walker B; other site 523791005771 D-loop; other site 523791005772 H-loop/switch region; other site 523791005773 hypothetical protein; Provisional; Region: PRK05415 523791005774 Domain of unknown function (DUF697); Region: DUF697; pfam05128 523791005775 YcjX-like family, DUF463; Region: DUF463; pfam04317 523791005776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791005777 binding surface 523791005778 TPR motif; other site 523791005779 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 523791005780 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 523791005781 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791005782 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523791005783 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523791005784 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 523791005785 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 523791005786 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 523791005787 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523791005788 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 523791005789 peptide binding site [polypeptide binding]; other site 523791005790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523791005791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791005792 dimer interface [polypeptide binding]; other site 523791005793 conserved gate region; other site 523791005794 putative PBP binding loops; other site 523791005795 ABC-ATPase subunit interface; other site 523791005796 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 523791005797 dipeptide transporter; Provisional; Region: PRK10913 523791005798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791005799 dimer interface [polypeptide binding]; other site 523791005800 ABC-ATPase subunit interface; other site 523791005801 putative PBP binding loops; other site 523791005802 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 523791005803 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523791005804 Walker A/P-loop; other site 523791005805 ATP binding site [chemical binding]; other site 523791005806 Q-loop/lid; other site 523791005807 ABC transporter signature motif; other site 523791005808 Walker B; other site 523791005809 D-loop; other site 523791005810 H-loop/switch region; other site 523791005811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523791005812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523791005813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523791005814 Walker A/P-loop; other site 523791005815 ATP binding site [chemical binding]; other site 523791005816 Q-loop/lid; other site 523791005817 ABC transporter signature motif; other site 523791005818 Walker B; other site 523791005819 D-loop; other site 523791005820 H-loop/switch region; other site 523791005821 periplasmic folding chaperone; Provisional; Region: PRK10788 523791005822 SurA N-terminal domain; Region: SurA_N_3; cl07813 523791005823 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 523791005824 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523791005825 IHF dimer interface [polypeptide binding]; other site 523791005826 IHF - DNA interface [nucleotide binding]; other site 523791005827 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 523791005828 Found in ATP-dependent protease La (LON); Region: LON; smart00464 523791005829 Found in ATP-dependent protease La (LON); Region: LON; smart00464 523791005830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791005831 Walker A motif; other site 523791005832 ATP binding site [chemical binding]; other site 523791005833 Walker B motif; other site 523791005834 arginine finger; other site 523791005835 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 523791005836 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 523791005837 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 523791005838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791005839 Walker A motif; other site 523791005840 ATP binding site [chemical binding]; other site 523791005841 Walker B motif; other site 523791005842 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523791005843 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523791005844 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 523791005845 active site 523791005846 metal binding site [ion binding]; metal-binding site 523791005847 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 523791005848 conserved hypothetical protein; Region: TIGR03843 523791005849 TLC ATP/ADP transporter; Region: TLC; cl03940 523791005850 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 523791005851 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 523791005852 oligomer interface [polypeptide binding]; other site 523791005853 active site residues [active] 523791005854 trigger factor; Provisional; Region: tig; PRK01490 523791005855 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791005856 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 523791005857 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 523791005858 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 523791005859 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 523791005860 homodimer interface [polypeptide binding]; other site 523791005861 NADP binding site [chemical binding]; other site 523791005862 substrate binding site [chemical binding]; other site 523791005863 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523791005864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523791005865 putative acyl-acceptor binding pocket; other site 523791005866 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 523791005867 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 523791005868 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 523791005869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523791005870 non-specific DNA binding site [nucleotide binding]; other site 523791005871 salt bridge; other site 523791005872 sequence-specific DNA binding site [nucleotide binding]; other site 523791005873 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 523791005874 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 523791005875 active site 523791005876 HIGH motif; other site 523791005877 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 523791005878 KMSKS motif; other site 523791005879 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 523791005880 tRNA binding surface [nucleotide binding]; other site 523791005881 anticodon binding site; other site 523791005882 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 523791005883 substrate binding site [chemical binding]; other site 523791005884 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523791005885 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 523791005886 putative active site [active] 523791005887 putative metal binding site [ion binding]; other site 523791005888 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 523791005889 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 523791005890 active site pocket [active] 523791005891 oxyanion hole [active] 523791005892 catalytic triad [active] 523791005893 active site nucleophile [active] 523791005894 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 523791005895 active site 523791005896 dinuclear metal binding site [ion binding]; other site 523791005897 dimerization interface [polypeptide binding]; other site 523791005898 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 523791005899 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 523791005900 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 523791005901 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 523791005902 Protein of unknown function DUF58; Region: DUF58; pfam01882 523791005903 MoxR-like ATPases [General function prediction only]; Region: COG0714 523791005904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791005905 Walker A motif; other site 523791005906 ATP binding site [chemical binding]; other site 523791005907 Walker B motif; other site 523791005908 arginine finger; other site 523791005909 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 523791005910 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 523791005911 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 523791005912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 523791005913 substrate binding site [chemical binding]; other site 523791005914 oxyanion hole (OAH) forming residues; other site 523791005915 trimer interface [polypeptide binding]; other site 523791005916 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 523791005917 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 523791005918 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 523791005919 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 523791005920 dimer interface [polypeptide binding]; other site 523791005921 active site 523791005922 MoxR-like ATPases [General function prediction only]; Region: COG0714 523791005923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791005924 Walker A motif; other site 523791005925 ATP binding site [chemical binding]; other site 523791005926 Walker B motif; other site 523791005927 arginine finger; other site 523791005928 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 523791005929 Protein of unknown function DUF58; Region: DUF58; pfam01882 523791005930 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 523791005931 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 523791005932 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 523791005933 metal ion-dependent adhesion site (MIDAS); other site 523791005934 von Willebrand factor type A domain; Region: VWA_2; pfam13519 523791005935 metal ion-dependent adhesion site (MIDAS); other site 523791005936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791005937 binding surface 523791005938 TPR motif; other site 523791005939 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523791005940 Oxygen tolerance; Region: BatD; pfam13584 523791005941 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 523791005942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791005943 NAD(P) binding site [chemical binding]; other site 523791005944 active site 523791005945 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 523791005946 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 523791005947 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 523791005948 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 523791005949 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 523791005950 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 523791005951 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 523791005952 Walker A/P-loop; other site 523791005953 ATP binding site [chemical binding]; other site 523791005954 Q-loop/lid; other site 523791005955 ABC transporter signature motif; other site 523791005956 Walker B; other site 523791005957 D-loop; other site 523791005958 H-loop/switch region; other site 523791005959 Predicted transcriptional regulators [Transcription]; Region: COG1725 523791005960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523791005961 DNA-binding site [nucleotide binding]; DNA binding site 523791005962 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 523791005963 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 523791005964 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 523791005965 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 523791005966 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 523791005967 putative NADH binding site [chemical binding]; other site 523791005968 putative active site [active] 523791005969 nudix motif; other site 523791005970 putative metal binding site [ion binding]; other site 523791005971 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523791005972 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 523791005973 motif 1; other site 523791005974 dimer interface [polypeptide binding]; other site 523791005975 active site 523791005976 motif 2; other site 523791005977 motif 3; other site 523791005978 elongation factor P; Validated; Region: PRK00529 523791005979 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 523791005980 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 523791005981 RNA binding site [nucleotide binding]; other site 523791005982 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 523791005983 RNA binding site [nucleotide binding]; other site 523791005984 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 523791005985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791005986 FeS/SAM binding site; other site 523791005987 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 523791005988 PAS domain; Region: PAS_9; pfam13426 523791005989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791005990 putative active site [active] 523791005991 heme pocket [chemical binding]; other site 523791005992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791005993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791005994 metal binding site [ion binding]; metal-binding site 523791005995 active site 523791005996 I-site; other site 523791005997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791005998 phosphoserine phosphatase SerB; Region: serB; TIGR00338 523791005999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791006000 motif II; other site 523791006001 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 523791006002 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 523791006003 CAP-like domain; other site 523791006004 active site 523791006005 primary dimer interface [polypeptide binding]; other site 523791006006 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 523791006007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791006008 ATP binding site [chemical binding]; other site 523791006009 Mg2+ binding site [ion binding]; other site 523791006010 G-X-G motif; other site 523791006011 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 523791006012 anchoring element; other site 523791006013 dimer interface [polypeptide binding]; other site 523791006014 ATP binding site [chemical binding]; other site 523791006015 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 523791006016 active site 523791006017 metal binding site [ion binding]; metal-binding site 523791006018 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 523791006019 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 523791006020 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523791006021 active site 523791006022 metal binding site [ion binding]; metal-binding site 523791006023 hexamer interface [polypeptide binding]; other site 523791006024 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 523791006025 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 523791006026 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 523791006027 dimer interface [polypeptide binding]; other site 523791006028 ADP-ribose binding site [chemical binding]; other site 523791006029 active site 523791006030 nudix motif; other site 523791006031 metal binding site [ion binding]; metal-binding site 523791006032 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 523791006033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006034 S-adenosylmethionine binding site [chemical binding]; other site 523791006035 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 523791006036 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 523791006037 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 523791006038 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523791006039 hypothetical protein; Validated; Region: PRK01777 523791006040 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 523791006041 putative coenzyme Q binding site [chemical binding]; other site 523791006042 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 523791006043 SmpB-tmRNA interface; other site 523791006044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791006045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523791006046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523791006047 active site 523791006048 ATP binding site [chemical binding]; other site 523791006049 substrate binding site [chemical binding]; other site 523791006050 activation loop (A-loop); other site 523791006051 HAMP domain; Region: HAMP; pfam00672 523791006052 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523791006053 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 523791006054 phosphopeptide binding site; other site 523791006055 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 523791006056 active site 523791006057 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 523791006058 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 523791006059 Cu(I) binding site [ion binding]; other site 523791006060 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 523791006061 Uncharacterized conserved protein [Function unknown]; Region: COG1262 523791006062 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 523791006063 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 523791006064 Multicopper oxidase; Region: Cu-oxidase; pfam00394 523791006065 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 523791006066 Cytochrome c; Region: Cytochrom_C; pfam00034 523791006067 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 523791006068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523791006069 substrate binding pocket [chemical binding]; other site 523791006070 membrane-bound complex binding site; other site 523791006071 PAS fold; Region: PAS_3; pfam08447 523791006072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791006073 putative active site [active] 523791006074 heme pocket [chemical binding]; other site 523791006075 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006077 metal binding site [ion binding]; metal-binding site 523791006078 active site 523791006079 I-site; other site 523791006080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791006081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006083 metal binding site [ion binding]; metal-binding site 523791006084 active site 523791006085 I-site; other site 523791006086 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 523791006087 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 523791006088 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 523791006089 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 523791006090 Cytochrome C' Region: Cytochrom_C_2; cl01610 523791006091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523791006092 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523791006093 Walker A/P-loop; other site 523791006094 ATP binding site [chemical binding]; other site 523791006095 Q-loop/lid; other site 523791006096 ABC transporter signature motif; other site 523791006097 Walker B; other site 523791006098 D-loop; other site 523791006099 H-loop/switch region; other site 523791006100 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523791006101 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523791006102 FtsX-like permease family; Region: FtsX; pfam02687 523791006103 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523791006104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 523791006105 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791006106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791006107 WHG domain; Region: WHG; pfam13305 523791006108 Predicted transcriptional regulator [Transcription]; Region: COG1959 523791006109 Transcriptional regulator; Region: Rrf2; cl17282 523791006110 Protein of unknown function (DUF454); Region: DUF454; cl01063 523791006111 Protein of unknown function (DUF454); Region: DUF454; pfam04304 523791006112 NnrS protein; Region: NnrS; pfam05940 523791006113 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 523791006114 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 523791006115 Hemerythrin-like domain; Region: Hr-like; cd12108 523791006116 Fe binding site [ion binding]; other site 523791006117 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 523791006118 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 523791006119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523791006120 N-terminal plug; other site 523791006121 ligand-binding site [chemical binding]; other site 523791006122 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 523791006123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791006124 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 523791006125 IucA / IucC family; Region: IucA_IucC; pfam04183 523791006126 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523791006127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 523791006128 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 523791006129 IucA / IucC family; Region: IucA_IucC; pfam04183 523791006130 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 523791006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006132 putative substrate translocation pore; other site 523791006133 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 523791006134 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 523791006135 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 523791006136 S-formylglutathione hydrolase; Region: PLN02442 523791006137 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 523791006138 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 523791006139 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 523791006140 substrate binding site [chemical binding]; other site 523791006141 catalytic Zn binding site [ion binding]; other site 523791006142 NAD binding site [chemical binding]; other site 523791006143 structural Zn binding site [ion binding]; other site 523791006144 dimer interface [polypeptide binding]; other site 523791006145 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 523791006146 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 523791006147 active site 523791006148 dimer interface [polypeptide binding]; other site 523791006149 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 523791006150 Ligand Binding Site [chemical binding]; other site 523791006151 Molecular Tunnel; other site 523791006152 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 523791006153 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523791006154 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523791006155 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 523791006156 Na binding site [ion binding]; other site 523791006157 allantoate amidohydrolase; Reviewed; Region: PRK09290 523791006158 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 523791006159 active site 523791006160 metal binding site [ion binding]; metal-binding site 523791006161 dimer interface [polypeptide binding]; other site 523791006162 RNA polymerase sigma factor; Provisional; Region: PRK12514 523791006163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791006164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791006165 DNA binding residues [nucleotide binding] 523791006166 putative anti-sigmaE protein; Provisional; Region: PRK13920 523791006167 Anti-sigma-K factor rskA; Region: RskA; pfam10099 523791006168 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 523791006169 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 523791006170 VCBS repeat; Region: VCBS_repeat; TIGR01965 523791006171 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 523791006172 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 523791006173 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 523791006174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 523791006175 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 523791006176 putative dimer interface [polypeptide binding]; other site 523791006177 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 523791006178 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791006179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 523791006180 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 523791006181 putative ATP binding site [chemical binding]; other site 523791006182 putative substrate interface [chemical binding]; other site 523791006183 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 523791006184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006185 muropeptide transporter; Reviewed; Region: ampG; PRK11902 523791006186 putative substrate translocation pore; other site 523791006187 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 523791006188 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 523791006189 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 523791006190 methionine sulfoxide reductase B; Provisional; Region: PRK00222 523791006191 SelR domain; Region: SelR; pfam01641 523791006192 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523791006193 Sporulation related domain; Region: SPOR; cl10051 523791006194 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523791006195 Sel1-like repeats; Region: SEL1; smart00671 523791006196 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 523791006197 putative FMN binding site [chemical binding]; other site 523791006198 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 523791006199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523791006200 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 523791006201 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 523791006202 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 523791006203 PA/protease or protease-like domain interface [polypeptide binding]; other site 523791006204 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 523791006205 metal binding site [ion binding]; metal-binding site 523791006206 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 523791006207 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 523791006208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006210 metal binding site [ion binding]; metal-binding site 523791006211 active site 523791006212 I-site; other site 523791006213 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 523791006214 short chain dehydrogenase; Provisional; Region: PRK06181 523791006215 NADP binding site [chemical binding]; other site 523791006216 homodimer interface [polypeptide binding]; other site 523791006217 substrate binding site [chemical binding]; other site 523791006218 active site 523791006219 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 523791006220 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 523791006221 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 523791006222 NAD(P) binding site [chemical binding]; other site 523791006223 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 523791006224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791006225 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 523791006226 dimerization interface [polypeptide binding]; other site 523791006227 substrate binding pocket [chemical binding]; other site 523791006228 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 523791006229 Amidinotransferase; Region: Amidinotransf; pfam02274 523791006230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523791006231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523791006232 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791006233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791006234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791006235 active site 523791006236 Protein of unknown function (DUF819); Region: DUF819; cl02317 523791006237 Protein of unknown function (DUF962); Region: DUF962; cl01879 523791006238 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 523791006239 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 523791006240 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 523791006241 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 523791006242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791006243 catalytic residue [active] 523791006244 PBP superfamily domain; Region: PBP_like_2; cl17296 523791006245 Cytochrome c; Region: Cytochrom_C; pfam00034 523791006246 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 523791006247 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 523791006248 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 523791006249 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 523791006250 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 523791006251 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523791006252 N-terminal plug; other site 523791006253 ligand-binding site [chemical binding]; other site 523791006254 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 523791006255 active site 2 [active] 523791006256 dimer interface [polypeptide binding]; other site 523791006257 active site 1 [active] 523791006258 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 523791006259 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523791006260 dimer interface [polypeptide binding]; other site 523791006261 active site 523791006262 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 523791006263 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 523791006264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791006265 putative active site [active] 523791006266 heme pocket [chemical binding]; other site 523791006267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791006268 dimer interface [polypeptide binding]; other site 523791006269 phosphorylation site [posttranslational modification] 523791006270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791006271 ATP binding site [chemical binding]; other site 523791006272 Mg2+ binding site [ion binding]; other site 523791006273 G-X-G motif; other site 523791006274 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 523791006275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791006276 active site 523791006277 phosphorylation site [posttranslational modification] 523791006278 intermolecular recognition site; other site 523791006279 dimerization interface [polypeptide binding]; other site 523791006280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791006281 DNA binding site [nucleotide binding] 523791006282 transcriptional regulator PhoU; Provisional; Region: PRK11115 523791006283 PhoU domain; Region: PhoU; pfam01895 523791006284 PhoU domain; Region: PhoU; pfam01895 523791006285 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 523791006286 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 523791006287 Walker A/P-loop; other site 523791006288 ATP binding site [chemical binding]; other site 523791006289 Q-loop/lid; other site 523791006290 ABC transporter signature motif; other site 523791006291 Walker B; other site 523791006292 D-loop; other site 523791006293 H-loop/switch region; other site 523791006294 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 523791006295 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 523791006296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791006297 ABC-ATPase subunit interface; other site 523791006298 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 523791006299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791006300 dimer interface [polypeptide binding]; other site 523791006301 conserved gate region; other site 523791006302 putative PBP binding loops; other site 523791006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791006304 dimer interface [polypeptide binding]; other site 523791006305 conserved gate region; other site 523791006306 putative PBP binding loops; other site 523791006307 ABC-ATPase subunit interface; other site 523791006308 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 523791006309 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 523791006310 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 523791006311 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523791006312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523791006313 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 523791006314 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 523791006315 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 523791006316 potential catalytic triad [active] 523791006317 conserved cys residue [active] 523791006318 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 523791006319 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 523791006320 active site triad [active] 523791006321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523791006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791006323 active site 523791006324 phosphorylation site [posttranslational modification] 523791006325 intermolecular recognition site; other site 523791006326 dimerization interface [polypeptide binding]; other site 523791006327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791006328 DNA binding site [nucleotide binding] 523791006329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523791006330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791006331 dimer interface [polypeptide binding]; other site 523791006332 phosphorylation site [posttranslational modification] 523791006333 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523791006334 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523791006335 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 523791006336 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 523791006337 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 523791006338 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 523791006339 dimer interface [polypeptide binding]; other site 523791006340 ssDNA binding site [nucleotide binding]; other site 523791006341 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523791006342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523791006344 putative substrate translocation pore; other site 523791006345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523791006346 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 523791006347 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523791006348 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523791006349 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 523791006350 Integral membrane protein TerC family; Region: TerC; pfam03741 523791006351 HEAT repeats; Region: HEAT_2; pfam13646 523791006352 HEAT repeats; Region: HEAT_2; pfam13646 523791006353 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 523791006354 active site 523791006355 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 523791006356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791006357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791006358 ABC transporter; Region: ABC_tran_2; pfam12848 523791006359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523791006360 PilZ domain; Region: PilZ; pfam07238 523791006361 Putative methyltransferase; Region: Methyltransf_4; cl17290 523791006362 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 523791006363 DNA repair protein RadA; Provisional; Region: PRK11823 523791006364 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523791006365 Walker A motif; other site 523791006366 ATP binding site [chemical binding]; other site 523791006367 Walker B motif; other site 523791006368 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 523791006369 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 523791006370 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 523791006371 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 523791006372 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 523791006373 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 523791006374 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 523791006375 AAA domain; Region: AAA_26; pfam13500 523791006376 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523791006377 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 523791006378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006379 S-adenosylmethionine binding site [chemical binding]; other site 523791006380 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 523791006381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 523791006382 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 523791006383 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 523791006384 substrate-cofactor binding pocket; other site 523791006385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791006386 catalytic residue [active] 523791006387 biotin synthase; Region: bioB; TIGR00433 523791006388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523791006389 FeS/SAM binding site; other site 523791006390 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 523791006391 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 523791006392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791006393 active site 523791006394 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 523791006395 Sensors of blue-light using FAD; Region: BLUF; pfam04940 523791006396 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 523791006397 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523791006398 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523791006399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523791006400 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 523791006401 active site 523791006402 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 523791006403 putative active site [active] 523791006404 Zn binding site [ion binding]; other site 523791006405 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 523791006406 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 523791006407 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 523791006408 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 523791006409 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 523791006410 nucleotide binding site [chemical binding]; other site 523791006411 substrate binding site [chemical binding]; other site 523791006412 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523791006413 Zinc-finger domain; Region: zf-CHCC; cl01821 523791006414 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 523791006415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 523791006416 metal binding triad; other site 523791006417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 523791006418 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 523791006419 metal binding triad; other site 523791006420 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 523791006421 Peptidase family M48; Region: Peptidase_M48; cl12018 523791006422 Uncharacterized conserved protein [Function unknown]; Region: COG3025 523791006423 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 523791006424 putative active site [active] 523791006425 putative metal binding residues [ion binding]; other site 523791006426 signature motif; other site 523791006427 putative triphosphate binding site [ion binding]; other site 523791006428 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 523791006429 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 523791006430 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 523791006431 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 523791006432 Bacterial SH3 domain; Region: SH3_3; pfam08239 523791006433 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 523791006434 Proline dehydrogenase; Region: Pro_dh; pfam01619 523791006435 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 523791006436 Glutamate binding site [chemical binding]; other site 523791006437 NAD binding site [chemical binding]; other site 523791006438 catalytic residues [active] 523791006439 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 523791006440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006441 S-adenosylmethionine binding site [chemical binding]; other site 523791006442 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 523791006443 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791006444 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523791006445 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791006446 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523791006447 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523791006448 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 523791006449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791006450 Walker A motif; other site 523791006451 ATP binding site [chemical binding]; other site 523791006452 Walker B motif; other site 523791006453 arginine finger; other site 523791006454 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 523791006455 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 523791006456 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 523791006457 active site 523791006458 NTP binding site [chemical binding]; other site 523791006459 metal binding triad [ion binding]; metal-binding site 523791006460 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 523791006461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791006462 Zn2+ binding site [ion binding]; other site 523791006463 Mg2+ binding site [ion binding]; other site 523791006464 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 523791006465 Uncharacterized conserved protein [Function unknown]; Region: COG1565 523791006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006467 S-adenosylmethionine binding site [chemical binding]; other site 523791006468 short chain dehydrogenase; Provisional; Region: PRK09134 523791006469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791006470 NAD(P) binding site [chemical binding]; other site 523791006471 active site 523791006472 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 523791006473 catalytic center binding site [active] 523791006474 ATP binding site [chemical binding]; other site 523791006475 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 523791006476 homooctamer interface [polypeptide binding]; other site 523791006477 active site 523791006478 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 523791006479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006480 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 523791006481 putative substrate translocation pore; other site 523791006482 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523791006483 Active site serine [active] 523791006484 UGMP family protein; Validated; Region: PRK09604 523791006485 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 523791006486 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 523791006487 Yqey-like protein; Region: YqeY; pfam09424 523791006488 DNA primase; Validated; Region: dnaG; PRK05667 523791006489 CHC2 zinc finger; Region: zf-CHC2; pfam01807 523791006490 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 523791006491 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 523791006492 active site 523791006493 metal binding site [ion binding]; metal-binding site 523791006494 interdomain interaction site; other site 523791006495 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 523791006496 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 523791006497 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 523791006498 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 523791006499 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 523791006500 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 523791006501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791006502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 523791006503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791006504 DNA binding residues [nucleotide binding] 523791006505 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 523791006506 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 523791006507 NodB motif; other site 523791006508 putative active site [active] 523791006509 putative catalytic site [active] 523791006510 putative Zn binding site [ion binding]; other site 523791006511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791006512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791006513 Amidohydrolase; Region: Amidohydro_4; pfam13147 523791006514 active site 523791006515 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791006516 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523791006517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523791006518 substrate binding pocket [chemical binding]; other site 523791006519 membrane-bound complex binding site; other site 523791006520 hinge residues; other site 523791006521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006523 metal binding site [ion binding]; metal-binding site 523791006524 active site 523791006525 I-site; other site 523791006526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791006527 Phospholipid methyltransferase; Region: PEMT; cl17370 523791006528 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 523791006529 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523791006530 Active site serine [active] 523791006531 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 523791006532 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 523791006533 conserved cys residue [active] 523791006534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523791006535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523791006537 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 523791006538 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 523791006539 ligand binding site [chemical binding]; other site 523791006540 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 523791006541 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 523791006542 Protein export membrane protein; Region: SecD_SecF; cl14618 523791006543 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523791006544 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791006545 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 523791006546 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 523791006547 Zn binding site [ion binding]; other site 523791006548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523791006550 putative substrate translocation pore; other site 523791006551 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 523791006552 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 523791006553 Zn binding site [ion binding]; other site 523791006554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523791006555 aconitate hydratase; Validated; Region: PRK09277 523791006556 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 523791006557 substrate binding site [chemical binding]; other site 523791006558 ligand binding site [chemical binding]; other site 523791006559 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 523791006560 substrate binding site [chemical binding]; other site 523791006561 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 523791006562 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 523791006563 ATP binding site [chemical binding]; other site 523791006564 active site 523791006565 substrate binding site [chemical binding]; other site 523791006566 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 523791006567 GIY-YIG motif/motif A; other site 523791006568 putative active site [active] 523791006569 putative metal binding site [ion binding]; other site 523791006570 dUTPase; Region: dUTPase_2; pfam08761 523791006571 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 523791006572 active site 523791006573 homodimer interface [polypeptide binding]; other site 523791006574 metal binding site [ion binding]; metal-binding site 523791006575 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 523791006576 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 523791006577 putative metal binding site [ion binding]; other site 523791006578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523791006579 HSP70 interaction site [polypeptide binding]; other site 523791006580 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 523791006581 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 523791006582 Substrate binding site; other site 523791006583 metal-binding site 523791006584 Phosphotransferase enzyme family; Region: APH; pfam01636 523791006585 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 523791006586 active site 523791006587 ATP binding site [chemical binding]; other site 523791006588 substrate binding site [chemical binding]; other site 523791006589 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 523791006590 OstA-like protein; Region: OstA; cl00844 523791006591 Organic solvent tolerance protein; Region: OstA_C; pfam04453 523791006592 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 523791006593 SurA N-terminal domain; Region: SurA_N; pfam09312 523791006594 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 523791006595 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 523791006596 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 523791006597 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 523791006598 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 523791006599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006600 S-adenosylmethionine binding site [chemical binding]; other site 523791006601 PilZ domain; Region: PilZ; pfam07238 523791006602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523791006603 active site 523791006604 division inhibitor protein; Provisional; Region: slmA; PRK09480 523791006605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791006606 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 523791006607 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 523791006608 active site 523791006609 substrate binding site [chemical binding]; other site 523791006610 metal binding site [ion binding]; metal-binding site 523791006611 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 523791006612 Flavoprotein; Region: Flavoprotein; pfam02441 523791006613 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 523791006614 hypothetical protein; Reviewed; Region: PRK00024 523791006615 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 523791006616 MPN+ (JAMM) motif; other site 523791006617 Zinc-binding site [ion binding]; other site 523791006618 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 523791006619 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 523791006620 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 523791006621 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 523791006622 DNA binding site [nucleotide binding] 523791006623 catalytic residue [active] 523791006624 H2TH interface [polypeptide binding]; other site 523791006625 putative catalytic residues [active] 523791006626 turnover-facilitating residue; other site 523791006627 intercalation triad [nucleotide binding]; other site 523791006628 8OG recognition residue [nucleotide binding]; other site 523791006629 putative reading head residues; other site 523791006630 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 523791006631 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 523791006632 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523791006633 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523791006634 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523791006635 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523791006636 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 523791006637 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 523791006638 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 523791006639 active site 523791006640 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 523791006641 nucleophile elbow; other site 523791006642 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 523791006643 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 523791006644 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 523791006645 active site 523791006646 (T/H)XGH motif; other site 523791006647 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 523791006648 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 523791006649 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 523791006650 NAD(P) binding site [chemical binding]; other site 523791006651 catalytic residues [active] 523791006652 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 523791006653 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 523791006654 substrate binding site [chemical binding]; other site 523791006655 active site 523791006656 Sporulation related domain; Region: SPOR; pfam05036 523791006657 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 523791006658 active site 523791006659 dimer interface [polypeptide binding]; other site 523791006660 metal binding site [ion binding]; metal-binding site 523791006661 shikimate kinase; Reviewed; Region: aroK; PRK00131 523791006662 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 523791006663 ADP binding site [chemical binding]; other site 523791006664 magnesium binding site [ion binding]; other site 523791006665 putative shikimate binding site; other site 523791006666 AMIN domain; Region: AMIN; pfam11741 523791006667 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 523791006668 Secretin and TonB N terminus short domain; Region: STN; smart00965 523791006669 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 523791006670 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 523791006671 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 523791006672 Pilus assembly protein, PilP; Region: PilP; pfam04351 523791006673 Pilus assembly protein, PilO; Region: PilO; cl01234 523791006674 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 523791006675 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 523791006676 Cell division protein FtsA; Region: FtsA; cl17206 523791006677 Competence protein A; Region: Competence_A; pfam11104 523791006678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 523791006679 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 523791006680 Transglycosylase; Region: Transgly; pfam00912 523791006681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 523791006682 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 523791006683 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523791006684 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 523791006685 primosome assembly protein PriA; Validated; Region: PRK05580 523791006686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523791006687 ATP binding site [chemical binding]; other site 523791006688 putative Mg++ binding site [ion binding]; other site 523791006689 helicase superfamily c-terminal domain; Region: HELICc; smart00490 523791006690 nucleotide binding region [chemical binding]; other site 523791006691 ATP-binding site [chemical binding]; other site 523791006692 Sporulation related domain; Region: SPOR; pfam05036 523791006693 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 523791006694 active site 523791006695 HslU subunit interaction site [polypeptide binding]; other site 523791006696 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 523791006697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791006698 Walker A motif; other site 523791006699 ATP binding site [chemical binding]; other site 523791006700 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 523791006701 Walker B motif; other site 523791006702 arginine finger; other site 523791006703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523791006704 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 523791006705 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 523791006706 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 523791006707 calcium binding site 2 [ion binding]; other site 523791006708 active site 523791006709 catalytic triad [active] 523791006710 calcium binding site 1 [ion binding]; other site 523791006711 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791006712 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 523791006713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 523791006714 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 523791006715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006716 S-adenosylmethionine binding site [chemical binding]; other site 523791006717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 523791006718 SCP-2 sterol transfer family; Region: SCP2; pfam02036 523791006719 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 523791006720 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 523791006721 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 523791006722 nucleotide binding site/active site [active] 523791006723 HIT family signature motif; other site 523791006724 catalytic residue [active] 523791006725 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 523791006726 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 523791006727 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 523791006728 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 523791006729 active site 523791006730 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 523791006731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791006732 putative active site [active] 523791006733 heme pocket [chemical binding]; other site 523791006734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791006735 putative active site [active] 523791006736 heme pocket [chemical binding]; other site 523791006737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006739 metal binding site [ion binding]; metal-binding site 523791006740 active site 523791006741 I-site; other site 523791006742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523791006743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791006744 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 523791006745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 523791006746 HlyD family secretion protein; Region: HlyD_3; pfam13437 523791006747 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 523791006748 Protein export membrane protein; Region: SecD_SecF; cl14618 523791006749 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 523791006750 Domain of unknown function DUF20; Region: UPF0118; pfam01594 523791006751 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 523791006752 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 523791006753 active site 523791006754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523791006755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523791006756 putative substrate translocation pore; other site 523791006757 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523791006758 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523791006759 putative acyl-acceptor binding pocket; other site 523791006760 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 523791006761 hydrophobic ligand binding site; other site 523791006762 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 523791006763 putative active site [active] 523791006764 dimerization interface [polypeptide binding]; other site 523791006765 putative tRNAtyr binding site [nucleotide binding]; other site 523791006766 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 523791006767 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 523791006768 G1 box; other site 523791006769 putative GEF interaction site [polypeptide binding]; other site 523791006770 GTP/Mg2+ binding site [chemical binding]; other site 523791006771 Switch I region; other site 523791006772 G2 box; other site 523791006773 G3 box; other site 523791006774 Switch II region; other site 523791006775 G4 box; other site 523791006776 G5 box; other site 523791006777 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 523791006778 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 523791006779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006781 metal binding site [ion binding]; metal-binding site 523791006782 active site 523791006783 I-site; other site 523791006784 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791006785 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791006786 metal binding site [ion binding]; metal-binding site 523791006787 active site 523791006788 I-site; other site 523791006789 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 523791006790 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 523791006791 Ligand Binding Site [chemical binding]; other site 523791006792 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 523791006793 CPxP motif; other site 523791006794 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 523791006795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006796 S-adenosylmethionine binding site [chemical binding]; other site 523791006797 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523791006798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791006799 binding surface 523791006800 TPR motif; other site 523791006801 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523791006802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791006803 TPR motif; other site 523791006804 binding surface 523791006805 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 523791006806 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 523791006807 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 523791006808 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 523791006809 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523791006810 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791006811 glutamine synthetase; Provisional; Region: glnA; PRK09469 523791006812 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 523791006813 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 523791006814 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 523791006815 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 523791006816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791006817 putative active site [active] 523791006818 heme pocket [chemical binding]; other site 523791006819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791006820 dimer interface [polypeptide binding]; other site 523791006821 phosphorylation site [posttranslational modification] 523791006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791006823 ATP binding site [chemical binding]; other site 523791006824 Mg2+ binding site [ion binding]; other site 523791006825 G-X-G motif; other site 523791006826 Response regulator receiver domain; Region: Response_reg; pfam00072 523791006827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791006828 active site 523791006829 phosphorylation site [posttranslational modification] 523791006830 intermolecular recognition site; other site 523791006831 dimerization interface [polypeptide binding]; other site 523791006832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 523791006833 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 523791006834 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 523791006835 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 523791006836 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 523791006837 preprotein translocase subunit SecB; Validated; Region: PRK05751 523791006838 SecA binding site; other site 523791006839 Preprotein binding site; other site 523791006840 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 523791006841 GSH binding site [chemical binding]; other site 523791006842 catalytic residues [active] 523791006843 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523791006844 active site residue [active] 523791006845 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 523791006846 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 523791006847 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 523791006848 phosphoglyceromutase; Provisional; Region: PRK05434 523791006849 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 523791006850 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 523791006851 Peptidase family M23; Region: Peptidase_M23; pfam01551 523791006852 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523791006853 C-terminal peptidase (prc); Region: prc; TIGR00225 523791006854 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 523791006855 protein binding site [polypeptide binding]; other site 523791006856 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 523791006857 Catalytic dyad [active] 523791006858 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 523791006859 Zn binding site [ion binding]; other site 523791006860 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 523791006861 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 523791006862 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 523791006863 dimer interface [polypeptide binding]; other site 523791006864 ADP-ribose binding site [chemical binding]; other site 523791006865 active site 523791006866 nudix motif; other site 523791006867 metal binding site [ion binding]; metal-binding site 523791006868 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 523791006869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791006870 active site 523791006871 motif I; other site 523791006872 motif II; other site 523791006873 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 523791006874 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 523791006875 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 523791006876 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 523791006877 GspL periplasmic domain; Region: GspL_C; cl14909 523791006878 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 523791006879 type II secretion system protein J; Region: gspJ; TIGR01711 523791006880 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 523791006881 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 523791006882 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 523791006883 Type II transport protein GspH; Region: GspH; pfam12019 523791006884 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 523791006885 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 523791006886 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 523791006887 type II secretion system protein F; Region: GspF; TIGR02120 523791006888 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523791006889 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523791006890 type II secretion system protein E; Region: type_II_gspE; TIGR02533 523791006891 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 523791006892 Walker A motif; other site 523791006893 ATP binding site [chemical binding]; other site 523791006894 Walker B motif; other site 523791006895 type II secretion system protein D; Region: type_II_gspD; TIGR02517 523791006896 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 523791006897 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 523791006898 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 523791006899 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 523791006900 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 523791006901 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 523791006902 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523791006903 RNA binding surface [nucleotide binding]; other site 523791006904 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 523791006905 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 523791006906 dimerization interface [polypeptide binding]; other site 523791006907 domain crossover interface; other site 523791006908 redox-dependent activation switch; other site 523791006909 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 523791006910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523791006911 dimerization interface [polypeptide binding]; other site 523791006912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791006913 dimer interface [polypeptide binding]; other site 523791006914 phosphorylation site [posttranslational modification] 523791006915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791006916 ATP binding site [chemical binding]; other site 523791006917 Mg2+ binding site [ion binding]; other site 523791006918 G-X-G motif; other site 523791006919 osmolarity response regulator; Provisional; Region: ompR; PRK09468 523791006920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791006921 active site 523791006922 phosphorylation site [posttranslational modification] 523791006923 intermolecular recognition site; other site 523791006924 dimerization interface [polypeptide binding]; other site 523791006925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791006926 DNA binding site [nucleotide binding] 523791006927 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 523791006928 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 523791006929 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 523791006930 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 523791006931 RNA binding site [nucleotide binding]; other site 523791006932 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 523791006933 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 523791006934 Protein of unknown function (DUF962); Region: DUF962; pfam06127 523791006935 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 523791006936 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 523791006937 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791006938 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 523791006939 Protein of unknown function (DUF423); Region: DUF423; pfam04241 523791006940 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 523791006941 putative acyl-acceptor binding pocket; other site 523791006942 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 523791006943 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 523791006944 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 523791006945 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 523791006946 Cu(I) binding site [ion binding]; other site 523791006947 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 523791006948 UbiA prenyltransferase family; Region: UbiA; pfam01040 523791006949 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 523791006950 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 523791006951 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 523791006952 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 523791006953 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 523791006954 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 523791006955 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 523791006956 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 523791006957 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 523791006958 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 523791006959 putative active site [active] 523791006960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 523791006961 DNA binding site [nucleotide binding] 523791006962 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 523791006963 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 523791006964 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 523791006965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523791006966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523791006967 catalytic residue [active] 523791006968 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 523791006969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523791006970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791006971 catalytic residues [active] 523791006972 Restriction endonuclease; Region: Mrr_cat; pfam04471 523791006973 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523791006974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791006975 S-adenosylmethionine binding site [chemical binding]; other site 523791006976 Preprotein translocase SecG subunit; Region: SecG; pfam03840 523791006977 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 523791006978 triosephosphate isomerase; Provisional; Region: PRK14567 523791006979 substrate binding site [chemical binding]; other site 523791006980 dimer interface [polypeptide binding]; other site 523791006981 catalytic triad [active] 523791006982 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 523791006983 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523791006984 E3 interaction surface; other site 523791006985 lipoyl attachment site [posttranslational modification]; other site 523791006986 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 523791006987 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 523791006988 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 523791006989 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 523791006990 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 523791006991 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 523791006992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 523791006993 catalytic loop [active] 523791006994 iron binding site [ion binding]; other site 523791006995 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 523791006996 FAD binding pocket [chemical binding]; other site 523791006997 FAD binding motif [chemical binding]; other site 523791006998 phosphate binding motif [ion binding]; other site 523791006999 beta-alpha-beta structure motif; other site 523791007000 NAD binding pocket [chemical binding]; other site 523791007001 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 523791007002 ApbE family; Region: ApbE; pfam02424 523791007003 Protein of unknown function (DUF539); Region: DUF539; cl01129 523791007004 FOG: CBS domain [General function prediction only]; Region: COG0517 523791007005 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 523791007006 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 523791007007 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 523791007008 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523791007009 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791007010 ligand binding site [chemical binding]; other site 523791007011 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 523791007012 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 523791007013 active site 523791007014 substrate binding site [chemical binding]; other site 523791007015 metal binding site [ion binding]; metal-binding site 523791007016 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 523791007017 dihydropteroate synthase; Region: DHPS; TIGR01496 523791007018 substrate binding pocket [chemical binding]; other site 523791007019 dimer interface [polypeptide binding]; other site 523791007020 inhibitor binding site; inhibition site 523791007021 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 523791007022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791007023 Walker A motif; other site 523791007024 ATP binding site [chemical binding]; other site 523791007025 Walker B motif; other site 523791007026 arginine finger; other site 523791007027 Peptidase family M41; Region: Peptidase_M41; pfam01434 523791007028 FtsJ-like methyltransferase; Region: FtsJ; cl17430 523791007029 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 523791007030 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 523791007031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523791007032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791007033 active site 523791007034 phosphorylation site [posttranslational modification] 523791007035 intermolecular recognition site; other site 523791007036 dimerization interface [polypeptide binding]; other site 523791007037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523791007038 DNA binding site [nucleotide binding] 523791007039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523791007040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523791007041 dimer interface [polypeptide binding]; other site 523791007042 phosphorylation site [posttranslational modification] 523791007043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791007044 ATP binding site [chemical binding]; other site 523791007045 Mg2+ binding site [ion binding]; other site 523791007046 G-X-G motif; other site 523791007047 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 523791007048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007049 S-adenosylmethionine binding site [chemical binding]; other site 523791007050 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 523791007051 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 523791007052 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 523791007053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007054 S-adenosylmethionine binding site [chemical binding]; other site 523791007055 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 523791007056 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 523791007057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 523791007058 Fatty acid desaturase; Region: FA_desaturase; pfam00487 523791007059 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 523791007060 Di-iron ligands [ion binding]; other site 523791007061 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 523791007062 SnoaL-like domain; Region: SnoaL_2; pfam12680 523791007063 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 523791007064 DNA photolyase; Region: DNA_photolyase; pfam00875 523791007065 Protein of unknown function (DUF523); Region: DUF523; pfam04463 523791007066 Uncharacterized conserved protein [Function unknown]; Region: COG3272 523791007067 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 523791007068 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 523791007069 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 523791007070 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 523791007071 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 523791007072 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 523791007073 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 523791007074 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 523791007075 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 523791007076 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523791007077 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523791007078 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 523791007079 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523791007080 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523791007081 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 523791007082 IMP binding site; other site 523791007083 dimer interface [polypeptide binding]; other site 523791007084 interdomain contacts; other site 523791007085 partial ornithine binding site; other site 523791007086 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 523791007087 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 523791007088 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 523791007089 catalytic site [active] 523791007090 subunit interface [polypeptide binding]; other site 523791007091 dihydrodipicolinate reductase; Provisional; Region: PRK00048 523791007092 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 523791007093 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 523791007094 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 523791007095 active site 523791007096 catalytic triad [active] 523791007097 oxyanion hole [active] 523791007098 switch loop; other site 523791007099 OPT oligopeptide transporter protein; Region: OPT; cl14607 523791007100 putative oligopeptide transporter, OPT family; Region: TIGR00733 523791007101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791007102 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 523791007103 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 523791007104 putative dimerization interface [polypeptide binding]; other site 523791007105 Domain of unknown function (DUF897); Region: DUF897; cl01312 523791007106 AIR carboxylase; Region: AIRC; pfam00731 523791007107 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 523791007108 ATP-grasp domain; Region: ATP-grasp; pfam02222 523791007109 chaperone protein DnaJ; Provisional; Region: PRK10767 523791007110 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523791007111 HSP70 interaction site [polypeptide binding]; other site 523791007112 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 523791007113 substrate binding site [polypeptide binding]; other site 523791007114 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 523791007115 Zn binding sites [ion binding]; other site 523791007116 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 523791007117 dimer interface [polypeptide binding]; other site 523791007118 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 523791007119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 523791007120 nucleotide binding site [chemical binding]; other site 523791007121 hypothetical protein; Provisional; Region: PRK12378 523791007122 HutD; Region: HutD; pfam05962 523791007123 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 523791007124 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 523791007125 dimer interface [polypeptide binding]; other site 523791007126 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 523791007127 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 523791007128 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 523791007129 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 523791007130 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 523791007131 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 523791007132 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523791007133 Walker A/P-loop; other site 523791007134 ATP binding site [chemical binding]; other site 523791007135 Q-loop/lid; other site 523791007136 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523791007137 Q-loop/lid; other site 523791007138 ABC transporter signature motif; other site 523791007139 Walker B; other site 523791007140 D-loop; other site 523791007141 H-loop/switch region; other site 523791007142 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 523791007143 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 523791007144 thymidylate synthase; Reviewed; Region: thyA; PRK01827 523791007145 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 523791007146 dimerization interface [polypeptide binding]; other site 523791007147 active site 523791007148 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 523791007149 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 523791007150 folate binding site [chemical binding]; other site 523791007151 NADP+ binding site [chemical binding]; other site 523791007152 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 523791007153 active site 523791007154 catalytic site [active] 523791007155 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 523791007156 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 523791007157 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 523791007158 metal ion-dependent adhesion site (MIDAS); other site 523791007159 hypothetical protein; Provisional; Region: PRK11770 523791007160 Domain of unknown function (DUF307); Region: DUF307; pfam03733 523791007161 Domain of unknown function (DUF307); Region: DUF307; pfam03733 523791007162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791007163 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523791007164 malate dehydrogenase; Provisional; Region: PRK05442 523791007165 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 523791007166 NAD(P) binding site [chemical binding]; other site 523791007167 dimer interface [polypeptide binding]; other site 523791007168 malate binding site [chemical binding]; other site 523791007169 Y-family of DNA polymerases; Region: PolY; cl12025 523791007170 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 523791007171 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 523791007172 ssDNA binding site; other site 523791007173 generic binding surface II; other site 523791007174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523791007175 ATP binding site [chemical binding]; other site 523791007176 putative Mg++ binding site [ion binding]; other site 523791007177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791007178 nucleotide binding region [chemical binding]; other site 523791007179 ATP-binding site [chemical binding]; other site 523791007180 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 523791007181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523791007182 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 523791007183 dimerization interface [polypeptide binding]; other site 523791007184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523791007185 tellurite resistance protein TehB; Provisional; Region: PRK11207 523791007186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007187 S-adenosylmethionine binding site [chemical binding]; other site 523791007188 Predicted membrane protein [Function unknown]; Region: COG2311 523791007189 Protein of unknown function (DUF418); Region: DUF418; cl12135 523791007190 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 523791007191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523791007192 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 523791007193 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 523791007194 homotrimer interaction site [polypeptide binding]; other site 523791007195 putative active site [active] 523791007196 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 523791007197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523791007198 Zn2+ binding site [ion binding]; other site 523791007199 Mg2+ binding site [ion binding]; other site 523791007200 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523791007201 synthetase active site [active] 523791007202 NTP binding site [chemical binding]; other site 523791007203 metal binding site [ion binding]; metal-binding site 523791007204 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 523791007205 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 523791007206 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 523791007207 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 523791007208 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 523791007209 catalytic site [active] 523791007210 G-X2-G-X-G-K; other site 523791007211 hypothetical protein; Provisional; Region: PRK11820 523791007212 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 523791007213 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 523791007214 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 523791007215 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 523791007216 active site 523791007217 metal binding site [ion binding]; metal-binding site 523791007218 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 523791007219 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 523791007220 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 523791007221 putative NAD(P) binding site [chemical binding]; other site 523791007222 homotetramer interface [polypeptide binding]; other site 523791007223 homodimer interface [polypeptide binding]; other site 523791007224 active site 523791007225 MAPEG family; Region: MAPEG; cl09190 523791007226 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 523791007227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523791007228 ribonuclease PH; Reviewed; Region: rph; PRK00173 523791007229 Ribonuclease PH; Region: RNase_PH_bact; cd11362 523791007230 hexamer interface [polypeptide binding]; other site 523791007231 active site 523791007232 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 523791007233 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 523791007234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 523791007235 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 523791007236 Malic enzyme, N-terminal domain; Region: malic; pfam00390 523791007237 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 523791007238 putative NAD(P) binding site [chemical binding]; other site 523791007239 Predicted membrane protein [Function unknown]; Region: COG2259 523791007240 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 523791007241 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 523791007242 active site 523791007243 FMN binding site [chemical binding]; other site 523791007244 substrate binding site [chemical binding]; other site 523791007245 3Fe-4S cluster binding site [ion binding]; other site 523791007246 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 523791007247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791007248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791007249 DNA binding residues [nucleotide binding] 523791007250 Putative zinc-finger; Region: zf-HC2; pfam13490 523791007251 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 523791007252 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 523791007253 metal binding site 2 [ion binding]; metal-binding site 523791007254 putative DNA binding helix; other site 523791007255 metal binding site 1 [ion binding]; metal-binding site 523791007256 dimer interface [polypeptide binding]; other site 523791007257 structural Zn2+ binding site [ion binding]; other site 523791007258 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523791007259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007260 S-adenosylmethionine binding site [chemical binding]; other site 523791007261 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 523791007262 putative active site [active] 523791007263 Ap4A binding site [chemical binding]; other site 523791007264 nudix motif; other site 523791007265 putative metal binding site [ion binding]; other site 523791007266 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 523791007267 putative DNA-binding cleft [nucleotide binding]; other site 523791007268 putative DNA clevage site; other site 523791007269 molecular lever; other site 523791007270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791007271 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 523791007272 tetramer interface [polypeptide binding]; other site 523791007273 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 523791007274 homodimer interface [polypeptide binding]; other site 523791007275 active site 523791007276 SAM binding site [chemical binding]; other site 523791007277 glycine dehydrogenase; Provisional; Region: PRK05367 523791007278 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 523791007279 tetramer interface [polypeptide binding]; other site 523791007280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791007281 catalytic residue [active] 523791007282 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 523791007283 tetramer interface [polypeptide binding]; other site 523791007284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523791007285 catalytic residue [active] 523791007286 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 523791007287 lipoyl attachment site [posttranslational modification]; other site 523791007288 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 523791007289 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 523791007290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791007291 Coenzyme A binding pocket [chemical binding]; other site 523791007292 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 523791007293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791007294 dimer interface [polypeptide binding]; other site 523791007295 conserved gate region; other site 523791007296 putative PBP binding loops; other site 523791007297 ABC-ATPase subunit interface; other site 523791007298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523791007299 dimer interface [polypeptide binding]; other site 523791007300 conserved gate region; other site 523791007301 putative PBP binding loops; other site 523791007302 ABC-ATPase subunit interface; other site 523791007303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 523791007304 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 523791007305 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 523791007306 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 523791007307 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 523791007308 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 523791007309 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 523791007310 proline aminopeptidase P II; Provisional; Region: PRK10879 523791007311 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 523791007312 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 523791007313 active site 523791007314 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 523791007315 TIGR02449 family protein; Region: TIGR02449 523791007316 Cell division protein ZapA; Region: ZapA; pfam05164 523791007317 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 523791007318 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 523791007319 Uncharacterized conserved protein [Function unknown]; Region: COG2947 523791007320 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 523791007321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523791007322 active site 523791007323 dimer interface [polypeptide binding]; other site 523791007324 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 523791007325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523791007326 active site 523791007327 phosphorylation site [posttranslational modification] 523791007328 intermolecular recognition site; other site 523791007329 dimerization interface [polypeptide binding]; other site 523791007330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523791007331 Walker A motif; other site 523791007332 ATP binding site [chemical binding]; other site 523791007333 Walker B motif; other site 523791007334 arginine finger; other site 523791007335 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 523791007336 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 523791007337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523791007338 ATP binding site [chemical binding]; other site 523791007339 Mg2+ binding site [ion binding]; other site 523791007340 G-X-G motif; other site 523791007341 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 523791007342 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 523791007343 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 523791007344 ligand binding site [chemical binding]; other site 523791007345 NAD binding site [chemical binding]; other site 523791007346 tetramer interface [polypeptide binding]; other site 523791007347 catalytic site [active] 523791007348 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 523791007349 L-serine binding site [chemical binding]; other site 523791007350 ACT domain interface; other site 523791007351 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 523791007352 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 523791007353 intersubunit interface [polypeptide binding]; other site 523791007354 active site 523791007355 zinc binding site [ion binding]; other site 523791007356 Na+ binding site [ion binding]; other site 523791007357 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 523791007358 Phosphoglycerate kinase; Region: PGK; pfam00162 523791007359 substrate binding site [chemical binding]; other site 523791007360 hinge regions; other site 523791007361 ADP binding site [chemical binding]; other site 523791007362 catalytic site [active] 523791007363 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 523791007364 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 523791007365 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 523791007366 transketolase; Reviewed; Region: PRK12753 523791007367 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 523791007368 TPP-binding site [chemical binding]; other site 523791007369 dimer interface [polypeptide binding]; other site 523791007370 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523791007371 PYR/PP interface [polypeptide binding]; other site 523791007372 dimer interface [polypeptide binding]; other site 523791007373 TPP binding site [chemical binding]; other site 523791007374 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523791007375 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 523791007376 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 523791007377 PAS fold; Region: PAS_3; pfam08447 523791007378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791007379 PAS domain; Region: PAS_9; pfam13426 523791007380 putative active site [active] 523791007381 heme pocket [chemical binding]; other site 523791007382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791007383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791007384 metal binding site [ion binding]; metal-binding site 523791007385 active site 523791007386 I-site; other site 523791007387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791007388 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 523791007389 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 523791007390 conserved cys residue [active] 523791007391 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 523791007392 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 523791007393 catalytic residues [active] 523791007394 Protein of unknown function, DUF599; Region: DUF599; pfam04654 523791007395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523791007396 Cytochrome c553 [Energy production and conversion]; Region: COG2863 523791007397 Cytochrome c; Region: Cytochrom_C; cl11414 523791007398 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 523791007399 G1 box; other site 523791007400 GTP/Mg2+ binding site [chemical binding]; other site 523791007401 Switch I region; other site 523791007402 G2 box; other site 523791007403 G3 box; other site 523791007404 Switch II region; other site 523791007405 G4 box; other site 523791007406 G5 box; other site 523791007407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523791007408 TPR motif; other site 523791007409 TPR repeat; Region: TPR_11; pfam13414 523791007410 binding surface 523791007411 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 523791007412 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 523791007413 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523791007414 DNA polymerase I; Provisional; Region: PRK05755 523791007415 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 523791007416 active site 523791007417 metal binding site 1 [ion binding]; metal-binding site 523791007418 putative 5' ssDNA interaction site; other site 523791007419 metal binding site 3; metal-binding site 523791007420 metal binding site 2 [ion binding]; metal-binding site 523791007421 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 523791007422 putative DNA binding site [nucleotide binding]; other site 523791007423 putative metal binding site [ion binding]; other site 523791007424 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 523791007425 active site 523791007426 catalytic site [active] 523791007427 substrate binding site [chemical binding]; other site 523791007428 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 523791007429 active site 523791007430 DNA binding site [nucleotide binding] 523791007431 catalytic site [active] 523791007432 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 523791007433 Protein of unknown function (DUF877); Region: DUF877; pfam05943 523791007434 Protein of unknown function (DUF770); Region: DUF770; pfam05591 523791007435 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 523791007436 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 523791007437 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 523791007438 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 523791007439 active site 523791007440 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 523791007441 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 523791007442 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 523791007443 G1 box; other site 523791007444 GTP/Mg2+ binding site [chemical binding]; other site 523791007445 G2 box; other site 523791007446 G3 box; other site 523791007447 Switch II region; other site 523791007448 G4 box; other site 523791007449 G5 box; other site 523791007450 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 523791007451 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 523791007452 hypothetical protein; Provisional; Region: PRK08126 523791007453 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 523791007454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523791007455 ligand binding site [chemical binding]; other site 523791007456 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 523791007457 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 523791007458 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 523791007459 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 523791007460 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523791007461 phosphopeptide binding site; other site 523791007462 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523791007463 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523791007464 active site 523791007465 ATP binding site [chemical binding]; other site 523791007466 substrate binding site [chemical binding]; other site 523791007467 activation loop (A-loop); other site 523791007468 aspartoacylase; Provisional; Region: PRK02259 523791007469 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 523791007470 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 523791007471 Staphylococcal nuclease homologue; Region: SNase; pfam00565 523791007472 Catalytic site; other site 523791007473 Uncharacterized conserved protein [Function unknown]; Region: COG2966 523791007474 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 523791007475 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 523791007476 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 523791007477 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 523791007478 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 523791007479 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 523791007480 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 523791007481 Pepsin-like aspartic proteases, bilobal enzymes that cleave bonds in peptides at acidic pH; Region: pepsin_like; cd05471 523791007482 Eukaryotic aspartyl protease; Region: Asp; pfam00026 523791007483 inhibitor binding site; inhibition site 523791007484 catalytic motif [active] 523791007485 catalytic residue [active] 523791007486 Active site flap [active] 523791007487 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 523791007488 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 523791007489 transmembrane helices; other site 523791007490 TrkA-C domain; Region: TrkA_C; pfam02080 523791007491 TrkA-C domain; Region: TrkA_C; pfam02080 523791007492 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 523791007493 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 523791007494 Predicted permeases [General function prediction only]; Region: RarD; COG2962 523791007495 EamA-like transporter family; Region: EamA; pfam00892 523791007496 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 523791007497 CoenzymeA binding site [chemical binding]; other site 523791007498 subunit interaction site [polypeptide binding]; other site 523791007499 PHB binding site; other site 523791007500 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 523791007501 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 523791007502 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 523791007503 epoxyqueuosine reductase; Region: TIGR00276 523791007504 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 523791007505 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 523791007506 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 523791007507 hydrophobic ligand binding site; other site 523791007508 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 523791007509 protein binding site [polypeptide binding]; other site 523791007510 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 523791007511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 523791007512 active site 523791007513 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 523791007514 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 523791007515 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 523791007516 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 523791007517 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791007518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523791007519 active site 523791007520 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523791007521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523791007522 binding surface 523791007523 TPR motif; other site 523791007524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791007525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791007526 metal binding site [ion binding]; metal-binding site 523791007527 active site 523791007528 I-site; other site 523791007529 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 523791007530 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 523791007531 dimerization interface [polypeptide binding]; other site 523791007532 DPS ferroxidase diiron center [ion binding]; other site 523791007533 ion pore; other site 523791007534 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 523791007535 CPxP motif; other site 523791007536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 523791007537 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 523791007538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 523791007539 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 523791007540 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 523791007541 dimer interface [polypeptide binding]; other site 523791007542 motif 1; other site 523791007543 active site 523791007544 motif 2; other site 523791007545 motif 3; other site 523791007546 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 523791007547 DALR anticodon binding domain; Region: DALR_1; pfam05746 523791007548 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 523791007549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523791007550 active site 523791007551 motif I; other site 523791007552 motif II; other site 523791007553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523791007554 NADH(P)-binding; Region: NAD_binding_10; pfam13460 523791007555 NAD(P) binding site [chemical binding]; other site 523791007556 active site 523791007557 Protein of unknown function, DUF481; Region: DUF481; pfam04338 523791007558 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 523791007559 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 523791007560 trimer interface [polypeptide binding]; other site 523791007561 putative metal binding site [ion binding]; other site 523791007562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791007563 PAS fold; Region: PAS_3; pfam08447 523791007564 putative active site [active] 523791007565 heme pocket [chemical binding]; other site 523791007566 PAS domain S-box; Region: sensory_box; TIGR00229 523791007567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 523791007568 putative active site [active] 523791007569 heme pocket [chemical binding]; other site 523791007570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 523791007571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 523791007572 metal binding site [ion binding]; metal-binding site 523791007573 active site 523791007574 I-site; other site 523791007575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 523791007576 TraB family; Region: TraB; pfam01963 523791007577 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 523791007578 glutathione reductase; Validated; Region: PRK06116 523791007579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523791007580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523791007581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523791007582 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523791007583 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523791007584 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 523791007585 active site 523791007586 nucleotide binding site [chemical binding]; other site 523791007587 HIGH motif; other site 523791007588 KMSKS motif; other site 523791007589 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 523791007590 putative metal binding site; other site 523791007591 oligopeptidase A; Provisional; Region: PRK10911 523791007592 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 523791007593 active site 523791007594 Zn binding site [ion binding]; other site 523791007595 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 523791007596 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 523791007597 putative N- and C-terminal domain interface [polypeptide binding]; other site 523791007598 putative active site [active] 523791007599 MgATP binding site [chemical binding]; other site 523791007600 catalytic site [active] 523791007601 metal binding site [ion binding]; metal-binding site 523791007602 putative carbohydrate binding site [chemical binding]; other site 523791007603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523791007604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523791007605 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 523791007606 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 523791007607 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 523791007608 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 523791007609 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 523791007610 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 523791007611 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 523791007612 putative uracil binding site [chemical binding]; other site 523791007613 putative active site [active] 523791007614 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523791007615 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523791007616 active site 523791007617 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 523791007618 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 523791007619 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 523791007620 SCAN oligomerization domain; Region: SCAN; cl02605 523791007621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007622 S-adenosylmethionine binding site [chemical binding]; other site 523791007623 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 523791007624 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 523791007625 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523791007626 P loop; other site 523791007627 GTP binding site [chemical binding]; other site 523791007628 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 523791007629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523791007630 Walker A/P-loop; other site 523791007631 ATP binding site [chemical binding]; other site 523791007632 Q-loop/lid; other site 523791007633 ABC transporter signature motif; other site 523791007634 Walker B; other site 523791007635 D-loop; other site 523791007636 H-loop/switch region; other site 523791007637 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 523791007638 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 523791007639 Uncharacterized conserved protein [Function unknown]; Region: COG2353 523791007640 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 523791007641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523791007642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523791007643 DNA binding residues [nucleotide binding] 523791007644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523791007645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523791007646 substrate binding pocket [chemical binding]; other site 523791007647 membrane-bound complex binding site; other site 523791007648 hinge residues; other site 523791007649 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 523791007650 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523791007651 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523791007652 putative acyl-acceptor binding pocket; other site 523791007653 Phosphopantetheine attachment site; Region: PP-binding; cl09936 523791007654 acyl carrier protein; Provisional; Region: PRK05350 523791007655 Predicted membrane protein [Function unknown]; Region: COG4648 523791007656 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 523791007657 4-coumarate--CoA ligase, photoactive yellow protein activation family; Region: 4_coum_CoA_lig; TIGR02372 523791007658 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 523791007659 CoA binding site [chemical binding]; other site 523791007660 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 523791007661 active site 2 [active] 523791007662 active site 1 [active] 523791007663 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523791007664 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 523791007665 Ligand binding site; other site 523791007666 Putative Catalytic site; other site 523791007667 DXD motif; other site 523791007668 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 523791007669 putative acyl-acceptor binding pocket; other site 523791007670 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 523791007671 active sites [active] 523791007672 tetramer interface [polypeptide binding]; other site 523791007673 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523791007674 active site 523791007675 Predicted exporter [General function prediction only]; Region: COG4258 523791007676 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 523791007677 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 523791007678 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 523791007679 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523791007680 dimer interface [polypeptide binding]; other site 523791007681 active site 523791007682 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 523791007683 putative active site 1 [active] 523791007684 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 523791007685 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 523791007686 NAD(P) binding site [chemical binding]; other site 523791007687 homotetramer interface [polypeptide binding]; other site 523791007688 homodimer interface [polypeptide binding]; other site 523791007689 active site 523791007690 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 523791007691 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523791007692 dimer interface [polypeptide binding]; other site 523791007693 active site 523791007694 FMN reductase; Validated; Region: fre; PRK08051 523791007695 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 523791007696 FAD binding pocket [chemical binding]; other site 523791007697 FAD binding motif [chemical binding]; other site 523791007698 phosphate binding motif [ion binding]; other site 523791007699 beta-alpha-beta structure motif; other site 523791007700 NAD binding pocket [chemical binding]; other site 523791007701 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 523791007702 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 523791007703 transcription termination factor Rho; Provisional; Region: rho; PRK09376 523791007704 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 523791007705 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 523791007706 RNA binding site [nucleotide binding]; other site 523791007707 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 523791007708 multimer interface [polypeptide binding]; other site 523791007709 Walker A motif; other site 523791007710 ATP binding site [chemical binding]; other site 523791007711 Walker B motif; other site 523791007712 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523791007713 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791007714 catalytic residues [active] 523791007715 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 523791007716 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523791007717 ATP binding site [chemical binding]; other site 523791007718 Mg++ binding site [ion binding]; other site 523791007719 motif III; other site 523791007720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523791007721 nucleotide binding region [chemical binding]; other site 523791007722 ATP-binding site [chemical binding]; other site 523791007723 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 523791007724 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 523791007725 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 523791007726 Putative Ig domain; Region: He_PIG; pfam05345 523791007727 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 523791007728 Family description; Region: VCBS; pfam13517 523791007729 Family description; Region: VCBS; pfam13517 523791007730 Family description; Region: VCBS; pfam13517 523791007731 Family description; Region: VCBS; pfam13517 523791007732 Family description; Region: VCBS; pfam13517 523791007733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 523791007734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523791007735 Coenzyme A binding pocket [chemical binding]; other site 523791007736 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 523791007737 Phage Tail Collar Domain; Region: Collar; pfam07484 523791007738 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 523791007739 Phage Tail Collar Domain; Region: Collar; pfam07484 523791007740 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 523791007741 Phage Tail Collar Domain; Region: Collar; pfam07484 523791007742 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 523791007743 Membrane transport protein; Region: Mem_trans; cl09117 523791007744 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 523791007745 dimer interface [polypeptide binding]; other site 523791007746 allosteric magnesium binding site [ion binding]; other site 523791007747 active site 523791007748 aspartate-rich active site metal binding site; other site 523791007749 Schiff base residues; other site 523791007750 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 523791007751 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 523791007752 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 523791007753 AIR carboxylase; Region: AIRC; pfam00731 523791007754 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523791007755 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523791007756 catalytic residues [active] 523791007757 Protein of unknown function (DUF494); Region: DUF494; pfam04361 523791007758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 523791007759 DNA protecting protein DprA; Region: dprA; TIGR00732 523791007760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 523791007761 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 523791007762 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 523791007763 active site 523791007764 catalytic residues [active] 523791007765 metal binding site [ion binding]; metal-binding site 523791007766 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 523791007767 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 523791007768 putative active site [active] 523791007769 substrate binding site [chemical binding]; other site 523791007770 putative cosubstrate binding site; other site 523791007771 catalytic site [active] 523791007772 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 523791007773 substrate binding site [chemical binding]; other site 523791007774 16S rRNA methyltransferase B; Provisional; Region: PRK10901 523791007775 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 523791007776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523791007777 S-adenosylmethionine binding site [chemical binding]; other site 523791007778 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 523791007779 TrkA-N domain; Region: TrkA_N; pfam02254 523791007780 TrkA-C domain; Region: TrkA_C; pfam02080 523791007781 TrkA-N domain; Region: TrkA_N; pfam02254 523791007782 TrkA-C domain; Region: TrkA_C; pfam02080 523791007783 Cation transport protein; Region: TrkH; cl17365 523791007784 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 523791007785 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 523791007786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 523791007787 putative acyl-acceptor binding pocket; other site 523791007788 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 523791007789 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 523791007790 catalytic residues [active] 523791007791 hinge region; other site 523791007792 alpha helical domain; other site 523791007793 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 523791007794 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 523791007795 glutaminase active site [active] 523791007796 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 523791007797 dimer interface [polypeptide binding]; other site 523791007798 active site 523791007799 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 523791007800 dimer interface [polypeptide binding]; other site 523791007801 active site 523791007802 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 523791007803 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 523791007804 Substrate binding site; other site 523791007805 Mg++ binding site; other site 523791007806 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 523791007807 active site 523791007808 substrate binding site [chemical binding]; other site 523791007809 CoA binding site [chemical binding]; other site 523791007810 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 523791007811 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 523791007812 gamma subunit interface [polypeptide binding]; other site 523791007813 epsilon subunit interface [polypeptide binding]; other site 523791007814 LBP interface [polypeptide binding]; other site 523791007815 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 523791007816 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523791007817 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 523791007818 alpha subunit interaction interface [polypeptide binding]; other site 523791007819 Walker A motif; other site 523791007820 ATP binding site [chemical binding]; other site 523791007821 Walker B motif; other site 523791007822 inhibitor binding site; inhibition site 523791007823 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523791007824 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 523791007825 core domain interface [polypeptide binding]; other site 523791007826 delta subunit interface [polypeptide binding]; other site 523791007827 epsilon subunit interface [polypeptide binding]; other site 523791007828 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 523791007829 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523791007830 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 523791007831 beta subunit interaction interface [polypeptide binding]; other site 523791007832 Walker A motif; other site 523791007833 ATP binding site [chemical binding]; other site 523791007834 Walker B motif; other site 523791007835 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523791007836 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 523791007837 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 523791007838 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 523791007839 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 523791007840 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 523791007841 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 523791007842 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 523791007843 ATP synthase I chain; Region: ATP_synt_I; cl09170 523791007844 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 523791007845 ParB-like nuclease domain; Region: ParBc; pfam02195 523791007846 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 523791007847 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 523791007848 P-loop; other site 523791007849 Magnesium ion binding site [ion binding]; other site 523791007850 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 523791007851 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 523791007852 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 523791007853 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 523791007854 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 523791007855 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 523791007856 CAAX protease self-immunity; Region: Abi; pfam02517 523791007857 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 523791007858 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 523791007859 DXD motif; other site 523791007860 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 523791007861 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 523791007862 trmE is a tRNA modification GTPase; Region: trmE; cd04164 523791007863 G1 box; other site 523791007864 GTP/Mg2+ binding site [chemical binding]; other site 523791007865 Switch I region; other site 523791007866 G2 box; other site 523791007867 Switch II region; other site 523791007868 G3 box; other site 523791007869 G4 box; other site 523791007870 G5 box; other site 523791007871 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 523791007872 membrane protein insertase; Provisional; Region: PRK01318 523791007873 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 523791007874 Haemolytic domain; Region: Haemolytic; pfam01809 523791007875 Ribonuclease P; Region: Ribonuclease_P; cl00457 523791007876 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399